Gene DUSP6 in Homo sapiens

Synonym: HH19, MKP3, PYST1, DUSP6

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP6
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP029_AA protein Get Run
HsapP029_AA_204-348 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 20-142 1.7e-16 52.7 Pfam-A 2-113 (113) alignment 
Range on Protein: 20-142
Range on HMM: 2-113/113.0
VAWLNEQLelGNERLLLMDCRPQELYESSHIESAINVAIPGImlrrlqkgnLPVRALFTRGEDRDRFTRRCG----TDTVVLYDesSSDWNENTGGESVL
  .| |.|  ..|...|.|.|..| |. .||. |.||. . .          | |.||.. .  . . ..       .|||.|.  .|... .......|
akelkell..ekekvvllDvRspeeyakghIpgAvnvpldsl.........yprrdlffkdklaeeleesgkkldkdktvvvyc..rsgnrsggaaalll

GLLLKKLKDEgcRAFYLEGGFSKFQAE
 |.||.|  .  . ..|.|||....||
alilkelgyk..nvyvLdGGfeawkae
PTEN_1 192-347 1e-33 111.8 In-house 28-191 (196) alignment 
Range on Protein: 192-347
Range on HMM: 28-191/196.0
TDSDGSPLSNSQPSFpvEILPFLYLGCAKDS-TNLDVLEEFGIKYILNVTPNLPN-------LFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEAR
  .. .  ..  .    || ..||.| .||   .|| |.| ||  ..|...  ..        ..... ..|...|| ||. ..||..| .. |||. ..
riiamgkapsrpllq..eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewll

GKNC--GVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
 ...   ||||| ||..||.||  ||||.| .|....| ..|. | ....||  .. .|| ... |
sdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael
subfamily_DSP6_pd Subfamily DSP6 198-350 6.9e-85 276.4 In-house 5-157 (158) alignment 
Range on Protein: 198-350
Range on HMM: 5-157/158.0
PLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGI
 |.... .|||||||.||||.|||..||.||....|||.||||.|||| ||..||.||.||||.||.||||..||||||.|||||| |...|||||||||
klkkaeaefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGi

SRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLS
|||||||.||||.||.||.|||||.||..|||||||||||||||||||.|.||
srsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrls
0044763 (Phosphotyrosine protein) phosphatases II 201-348 2e-42 140.2 In-house 17-171 (178) alignment 
Range on Protein: 201-348
Range on HMM: 17-171/178.0
NSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGE-------FKYKQIPISDHWSQNLSQFFPEAISFIDEAR-GKNCGVLVH
 |..  ..||||.||||.. .. .|. | | ||..|.|.|..|.. |..  .       ..|..|||.||  ..|...|.|.. ||.||.  |.. ||||
rsdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVH

CLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSnISPNFNFMGQLLDFERTLG
| ||..|| |. .|||| ||.||...|.. |..... |.||.... ||..||. | 
CsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_LRR-DSP_pd Subfamily LRR-DSP 203-347 1.1e-35 117.0 In-house 116-258 (263) alignment 
Range on Protein: 203-347
Range on HMM: 116-258/263.0
QPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAgeFKYKQI-PISDHWSQNLSQFFPEAISFIDEARgKNCGVLVHCLAGISRSV
. | | ||.. |.||. . ..|  .|.. |. .||    ..  || .   |||  |  | |    ..||.| |  .||.| | |. |||||| ||.||| 
vssvPdeiidklflGgldsannksilkdlgvthillavadfePlfPkl..fkylsiddiedvdeadisqhfeetnafieeGr.kkGGvlvhcraGvsrss

TVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
|....|||.| .| ...|.|.|. |...| ||  |. ||. .|. |
tlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
subfamily_DSP1_pd Subfamily DSP1 204-349 5.8e-48 157.0 In-house 13-158 (163) alignment 
Range on Protein: 204-349
Range on HMM: 13-158/163.0
PSF-PVE-ILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENagEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSV
. . ||| ||.||||| .....||..|.. ||  ||||. .|.| ||.   |.||.....|. ....|. | |.| ||||.. ||  ||.|| |||||| 
klydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRss

TVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGL
|. .||||.. ..|...|.| || ..| ||||..|..|||..|..|.|
tlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklll
0048179 (Phosphotyrosine protein) phosphatases II 204-346 2.1e-38 126.6 In-house 1-143 (144) alignment 
Range on Protein: 204-346
Range on HMM: 1-143/144.0
PSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTV
||.|.|||| ||||.  .. .|. | ..||....|.|.. .. |.    ..| ..|. ||   .|.....|.. ||.||. ... ||||| ||..|. |.
psnpseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtl

TVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERT
 .|||| ||.||...|.. |... ... ||.... .||..|. 
vaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
0048076 (Phosphotyrosine protein) phosphatases II 204-346 1.6e-37 123.7 In-house 1-141 (145) alignment 
Range on Protein: 204-346
Range on HMM: 1-141/145.0
PSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFenAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTV
|..| |||| ||||.  .  .|. |...||...||.|..|..|.  .  ..| ..|. ||  ..|.....|.. ||.||. ... ||||| ||..|. |.
pywpseilpglylgslptaldlellkdlgittvlnltselelle..rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtl

TVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERT
 .|||| .|..|. .|.. |... ... ||.... .|..||. 
vaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefele
subfamily_STYXL1_pd Subfamily STYXL1 204-347 1.2e-28 93.3 In-house 8-153 (157) alignment 
Range on Protein: 204-347
Range on HMM: 8-153/157.0
PSFPVEILP-FLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGE-FKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSV
...|||.|| .||||  |...|  . ... .|  .||. .  .|..   .  |  .|...|.   .| ... ||..||.. . ..  |||    |||||.
ktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsa

TVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
.| .|||| . ......||. .|  |.|. || .|. || ..|..|
aviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
0045098 (Phosphotyrosine protein) phosphatases II 204-347 1.7e-28 95.2 In-house 19-271 (278) alignment 
Range on Protein: 204-347
Range on HMM: 19-271/278.0
PSFPVEILPFLYLGCAK-----------------------------------------DSTNLDVLEEFGIKYILNVTPNL-------------------
...| ||.|.||||...                                          . ... | | ||..|...|. .                   
lgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslty

-----------------------------PNLFENAGEFKYKQIPISDHWSQNLS--QFFPEAISFIDEARG--------------KNCGVLVHCLAGIS
                             .. .|..| . .. .|. || . .|.  ..| |.. ||.||.               ... ||||| ||..
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RSVTVTVAYLMQKL---NLSMNDAYDIVKMKKSN-ISPNFNFMGQLLDFERTL
|. |. .|||| .|   .... .|.. ..... . . .|.... .| .|.. |
RtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_Slingshot_pd Subfamily Slingshot 205-347 3.4e-35 114.9 In-house 17-157 (169) alignment 
Range on Protein: 205-347
Range on HMM: 17-157/169.0
SFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFEnaGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVT
  . .|  ..|||   ...||. |.| |..|||||| .. | |.  ..|.|..| . |. ...| ... |. .||..|. |.  |||||  |.||| .. 
dsaskifdhvylGsewnasnleelkengveyilnvtkeidnffp..ekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastv

VAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
.|| |.. .||...|.. || ..| | || .|. ||  .|  |
iayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGil
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 205-345 2.1e-30 99.2 In-house 5-145 (148) alignment 
Range on Protein: 205-345
Range on HMM: 5-145/148.0
SFPVEILP-FLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGeFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTV
 || || . ||.||  |  ..|..|...|.  | | | . .| ... |  .| .....|.  ..||..|...|.|...|...   ||||.  |.|||  .
tfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrg.ieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssal

TVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
....|..  . |...|...|| |.  . ||  |. || ..|.
allwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_DSP8_pd Subfamily DSP8 206-348 1.5e-46 151.9 In-house 14-155 (159) alignment 
Range on Protein: 206-348
Range on HMM: 14-155/159.0
FPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLfENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTV
 | .||..||||. ||. . ..|.. || |.||.  . |.| |   | |. ..|. |. . .|...|.....||| |. .|. ||||.||||||| || .
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkl.eelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvai

AYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLG
||.|..|..|...||  || |.  ||||.||.||||..|..| 
ayimktlemsldeayrfvkekrptispnlnflgqLleyekelk
0043147 (Phosphotyrosine protein) phosphatases II 206-347 1e-35 118.3 In-house 18-160 (172) alignment 
Range on Protein: 206-347
Range on HMM: 18-160/172.0
FPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPN-LPNLFENAGEFKYKQIPISDHWSQnLSQFFPEAISFIDE--ARGKNCGVLVHCLAGISRSVT
 | ..........  .. ... | | ||..|.|.|.  ..  ..    ..|  .|. ||. . |.....|...||||  |. ... ||||| ||..|..|
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

VTVAYLMQkLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
. .||||. |.||. .|.. |..|......|.... .|..||..|
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0041856 (Phosphotyrosine protein) phosphatases II 206-347 1.8e-33 111.1 In-house 18-172 (182) alignment 
Range on Protein: 206-347
Range on HMM: 18-172/182.0
FPVEILPFLYLGCAKD--------------STNLDVLEEFGIKYILNVTpnL----PNLFENAGeFKYKQIPISDHWSQNlsqfFPEAISFIDEARGKNC
.. .|.. ||||. ..                .|. | | ||..|.|.|       |.|.|..| ..|...|. ||   .    ..|...||.|.. ...
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlg.iqylylpwpDhgvpd....ldelldfieevleegg

GVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKS--NISPNFNFMGQLLDFERTL
 ||||| ||..|. |. .|||| ||..|. .|.. |.....   |.||..|. ||. .|. |
pvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
0046846 (Phosphotyrosine protein) phosphatases II 206-346 5.5e-30 99.8 In-house 11-171 (176) alignment 
Range on Protein: 206-346
Range on HMM: 11-171/176.0
FPVEILPFLYLGCAK----------DSTNLDVLEEFGIKYILNVT----------PNLPNLFENAGEfKYKQIPISDHWSQNLsQFFPEAISFIDEARGK
....|.. |.||..             ..|. | | ||....|.|          ||.....|..|  .|...|. ||.  .| . ..|.. ||.||. .
dldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.qylhlpwpDhgvpdl.elllellefirealke

NCGVLVHCLAGISRSVTVTVAYLMQK-LNLSMNDAYDIVKMKKS-NISPNFNFMGQLLDFERT
.  ||||| |||.|. |. .|||...  .||...|.. |..... .. ...... .| .||. 
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
subfamily_MKPLT_pd Subfamily MKPLT 206-345 5.4e-27 88.3 In-house 20-158 (164) alignment 
Range on Protein: 206-345
Range on HMM: 20-158/164.0
FPVEILP-FLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAgeFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVT
.|  .|.  |||| ||..||  ||..  |..|.||. .  . | ..  ..| |. ..|   ..||.|.  |  |. .|      |||||  | ||| .||
ypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpks..veYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvt

VAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
||.|..     ...||. .| ..| ..||  |. ||  ||.
vafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 206-345 5.4e-27 88.3 In-house 20-158 (164) alignment 
Range on Protein: 206-345
Range on HMM: 20-158/164.0
FPVEILP-FLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAgeFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVT
.|  .|.  |||| ||..||  ||..  |..|.||. .  . | ..  ..| |. ..|   ..||.|.  |  |. .|      |||||  | ||| .||
ypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpks..veYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvt

VAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
||.|..     ...||. .| ..| ..||  |. ||  ||.
vafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_DSP10_pd Subfamily DSP10 207-347 5.7e-61 199.0 In-house 14-153 (159) alignment 
Range on Protein: 207-347
Range on HMM: 14-153/159.0
PVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENaGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVA
 ...||||.|| .||...||.|....|...||||...|| ||.  ..|||.||.||  .|||.| | ||. ||.||| |.  ||||| ||||||.||..|
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
|||..||||.||||. || |.. ||||.|||||||.||..|
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekel
PTPc_motif_SM00404 207-345 1.7e-45 149.4 In-house 2-139 (140) alignment 
Range on Protein: 207-345
Range on HMM: 2-139/140.0
PVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLfENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVA
| .||| |||| .....|...|...||....||| . ..  ..  .|...|||..|. ...||........||..|. |.. ||||| ||.|||.|...|
psrilphlylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
|||.. .||...||..|| ....||||.||. ||...|.
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0049260 (Phosphotyrosine protein) phosphatases II 207-347 2e-32 107.4 In-house 8-149 (152) alignment 
Range on Protein: 207-347
Range on HMM: 8-149/152.0
PVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFE-NAGEFKYKQIPISDHWSQNLSQFFPEAISFIDE-ARGKNCGVLVHCLAGISRSVTVT
| |.......|.   . ... | | ||..|...|  |.. ..  .  ..|...|. ||. ..|||...... ||.. |. |.. ||||| ||..|. |. 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

VAYLMQkLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
.||||  |..|. .|.. |..|.... ||.... .|..||..|
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
0037934 (Phosphotyrosine protein) phosphatases II 207-346 8.1e-27 89.8 In-house 39-240 (243) alignment 
Range on Protein: 207-346
Range on HMM: 39-240/243.0
PVEILPFLYLGCA--------KDSTNLDVLEEFGIKYILNVTPNL------------------------------------------PN-LFENAGEFKY
 ....| |.....        .. .... | | ||..|...|.                                            ..   .    ..|
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

KQIPISDH---W-SQNLSQFFPEAISFIDE-----ARGKNCGVLVHCLAGISRSVTVTVAYLMQKL-NLSMNDAYDIVKMKKSN-ISPNFNFMGQLLDFE
 ..|. ||      ..| .|. |...||.|     |. ..  ||||| ||..|. |. .|||| .| .... .|.. ....... . ...... .| ...
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal

RT
. 
le
subfamily_DSP14_pd Subfamily DSP14 208-347 1.3e-33 110.1 In-house 8-144 (157) alignment 
Range on Protein: 208-347
Range on HMM: 8-144/157.0
VEILPFLYLGcAKDSTNLDVLEEFGIKYILNVTPNLPNlfENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAY
..| | |.|. .  ... ..|.. .|  |.|||..|||  ... .... ..|..|. ...|...| |..  |.|.. |.  .|||| ||.||| ....||
sqitpsLfls.gvaalskellkkkkitliinvtvelpn..tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

LMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
||.  .||...|| .|| ... |.||  |  || |.|. |
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkkl
0036282 (Phosphotyrosine protein) phosphatases II 208-347 7.3e-30 99.3 In-house 13-169 (174) alignment 
Range on Protein: 208-347
Range on HMM: 13-169/174.0
VEILPFLYLGCAKDStNLDVLEEFGIKYILNVTPNLPN-------------LFENAGEFKYKQIPISDHWSQNLSQfFPEAISFIDEARGK--NCGVLVH
..|.| |..|..  . ... | |.||........  ..              ..    ..|...|. ||   .||. . |...|..||. .  .. ||||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CLAGISRSVTVTVAYLMQKLNL-SMNDAYDIVKMKK---SNISPNFNFMGQLLDFERTL
| ||..|. |. .|||| .. | |. ||.|.|....   ... ...... .| .||. |
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
subfamily_DSP12_pd Subfamily DSP12 209-346 6.8e-39 127.7 In-house 4-142 (155) alignment 
Range on Protein: 209-346
Range on HMM: 4-142/155.0
EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPN-LPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAY
.||| |||| ... .. . |.|..|. .| |. . ||.  ...|. ..|.|.| |. .... ....||..||.||. ..  ||||| ||.|||||. .||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERT
||.| .||...|...|| ||..|.|| .|. ||  ||. 
lmkkeklslekAlklvkekkpeiepNegFleQLklfekm
subfamily_DSP19_pd Subfamily DSP19 209-346 1.5e-38 126.5 In-house 14-149 (152) alignment 
Range on Protein: 209-346
Range on HMM: 14-149/152.0
EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENagEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYL
|. | ||||     .. . |.| .| .||||. ..||.| .  .|.|..|.| |.  ..|.....||. ||.||| |.  ||||| ||.|||..| .|||
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpk..dftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviayl

MQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERT
|.| .||...|.. |. .. .|.||  |. || ..| .
mkkeelsleealelvrearpcikPneGFikqLkeyeae
subfamily_DSP15_pd Subfamily DSP15 209-346 7.3e-38 124.0 In-house 4-138 (151) alignment 
Range on Protein: 209-346
Range on HMM: 4-138/151.0
EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENageFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYL
..|| ||||  .|| . . |.|  |  ||.|  |  .|...   ..|| |..||  |..||.|| |...|| ..| |. .||||||||.|||||..||||
kvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd...ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERT
|  ..|. .|| ...|...|   ||| |  || ..|.|
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt
subfamily_DSP3_pd Subfamily DSP3 209-347 8.6e-29 94.3 In-house 13-157 (162) alignment 
Range on Protein: 209-347
Range on HMM: 13-157/162.0
EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPN-L-----PNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGK-NCGVLVHCLAGISRSV
|. | ||.| .. ... . |...|| ..|| .   .      . | .  |.||  ....|  . .||..| .| .|||||  . .  ||||| .|.||| 
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

TVTVAYLMQKLNLSMNDAYDIVKMKKsNISPNFNFMGQLLDFERTL
|. .|||| . ......|   |..|. .| ||  |. || .... |
tlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeel
0051082 (Phosphotyrosine protein) phosphatases II 209-342 5.6e-25 83.1 In-house 10-148 (151) alignment 
Range on Protein: 209-342
Range on HMM: 10-148/151.0
EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTP-----NLPNLFENAGeFKYKQIPISDHWSQNLSQFFPEAISFIDEARGK-NCGVLVHCLAGISRSVT
 . ..||.. .  . .|. |.| |||.|.|...     ..|......| .....||| |.. ..|...|.....|..... | |  ||||| ||..|. |
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelg.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

VTVAYLMQkLNLSMNDAYDIVKMKKS-NISPNFNFMGQLLD
. ..|||  |..|...|.. ...|    . ||  |. ||..
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
0042113 (Phosphotyrosine protein) phosphatases II 209-345 4.4e-24 80.7 In-house 49-240 (245) alignment 
Range on Protein: 209-345
Range on HMM: 49-240/245.0
EILPFLYLGCAKDSTNLD----VLEEFGIKYILNVTPNLP--------------------------------------------NLFENAGEFKYKQIPI
.| | .... .  . ...     | | ||..|...|.  .                                              .|    . | ..|.
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

SDHWSQNLSQFFPEAISFIDEARG--KNCGVLVHCLAGISRSVTVTVAYLM-----QKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
 ||   .|.. . ....|...|.   .|  ||||| ||..|. |. .||||       |..|. .|.. ........ ...... .| ....
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_STYX_pd Subfamily STYX 209-345 6.8e-23 74.6 In-house 14-155 (166) alignment 
Range on Protein: 209-345
Range on HMM: 14-155/166.0
EILPFLYLGC--AKDSTNLDVLEEFGIKYILNVTPNLPNLFE---NAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTV
|||| |.||   |   . |.||.. || .|. .  |.   .       .|.|  . ..|   .|. ...|.  .|||..  |   ||||  |||||| ..
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

TVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
 .||.|.   |   .|.  |. ..  |.||  |. || ..| 
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 213-346 5.6e-26 84.7 In-house 9-151 (154) alignment 
Range on Protein: 213-346
Range on HMM: 9-151/154.0
FLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENA-------GEFKYKQIPISDHWSQNLSQFFPEAISFIDEAR--GKNCGVLVHCLAGISRSVTV
|||..  . . |   |..  || ||||    .||| .          ..| .. . |.  ... . .  |  |||.|    .| .||||. .|.||| ..
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

TVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERT
 ..|||.||..|.  |. ..|  .  |.||  |. ||  ||. 
lisylmdklkislslalellkdsryiikPnqGflkqleifeke
DSPc Dual specificity phosphatase, catalytic domain 214-345 2.9e-44 145.2 Pfam-A 1-132 (133) alignment 
Range on Protein: 214-345
Range on HMM: 1-132/133.0
LYLGCAKDSTnLDVLEEFGIKYILNVTPNLPN-LFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKL
|||| ..... |..||..||....||| . ||  . . .|..| .||. |......|....||..||..|. |.. ||||| |||||| |...||||.. 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
|||.|.||..|| ..|.||||..|..|||..||
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 214-345 2.9e-44 145.2 In-house 1-132 (133) alignment 
Range on Protein: 214-345
Range on HMM: 1-132/133.0
LYLGCAKDSTnLDVLEEFGIKYILNVTPNLPN-LFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKL
|||| ..... |..||..||....||| . ||  . . .|..| .||. |......|....||..||..|. |.. ||||| |||||| |...||||.. 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
|||.|.||..|| ..|.||||..|..|||..||
nlslneAyefvkerrskispnagflrqLleyer
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 214-347 2.4e-26 85.6 In-house 6-141 (145) alignment 
Range on Protein: 214-347
Range on HMM: 6-141/145.0
LYLGCAKDSTNLDVLEEFGIKYILNVTP--NLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQK
|| | |  . .. .|.|.||  |.|..    .     .. ...   |  .|  | .||| | |   |||  . .  ||.|||.||.||||||.||.||. 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

LNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
 |... .|   |. ..    || .|. .||..|. |
cnmtlseaarqvrsnrllaypnvtflknllnlekql
0051429 (Phosphotyrosine protein) phosphatases II 218-345 2.4e-18 62.2 In-house 28-222 (272) alignment 
Range on Protein: 218-345
Range on HMM: 28-222/272.0
CAK---DSTNLDVLEEFGIKYILNVTPNL----PNLFENAGEFKYKQIPISDHWSQNLSQFF--------------------------------------
 .    .  ... |.| |||.|.....       . .  .  ..| ..|| |.  .  ....                                      
ggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhy

----------PEAISFIDEARGkNCGVLVHCLAGISRSVTVTVAYLMQkLNLS--------------MNDAYDIVKMKKSNISPNFNFMGQLLDFER
           . ...... .  .  ||||| ||..|. || ...|.  |..|              . .|.. .. .  .. ..  .. .|.....
tdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeall
subfamily_DSP23_pd Subfamily DSP23 223-325 2.4e-11 38.5 In-house 22-123 (148) alignment 
Range on Protein: 223-325
Range on HMM: 22-123/148.0
TNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFfPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDI
 ..  | . |..|.. .| . .   | . .  .... | |.    | |   | .  ..||  ||  | |||| |  |. |.   ||... .|.  .|   
dqyrylldlgvrylvslteegrphveatpnltlvrlriddyhppaleqv.vefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiae

VKM
|. 
vrr
0040439 (Phosphotyrosine protein) phosphatases II 224-347 5.9e-26 87.0 In-house 70-245 (249) alignment 
Range on Protein: 224-347
Range on HMM: 70-245/249.0
NLDVLEEFGIKYILNVTPNLPNLF-----------------------------------------ENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEA
... | | ||..|...|.  .. .                                         ..  ......|.. |   ......|.....||...
fwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieav

RG------KNCGVLVHCLAGISRSVTVTVAYLM-----QKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
|       |.. ||||| ||..|. |. .||||      .|.... .|.. ........ .|.... .|..... |
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0049772 (Phosphotyrosine protein) phosphatases II 225-347 2.8e-31 104.8 In-house 163-273 (314) alignment 
Range on Protein: 225-347
Range on HMM: 163-273/314.0
LDVLEefgikyilnvtPNL--PNLFENAGeFKYKQIPISDhWSQNLSQFFPEAISFIDEArGKNCGVLVHCLAGISRSVT-VTVAYLMQKLNLSMNDAYD
|. |.           . |  |.|||..| .||..||..| .|..|...|.|.. ||.||  |.  ||||| ||..|. | |..|||| .|..|...|..
lellk...........eelydpelferlg.ikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleeale

IVKMKKSnISPNFNFMGQLLDFERTL
 |..| . |.||..|. ||...|  |
dvrlkRp.inpnpgfieqleqyefil
0045450 (Phosphotyrosine protein) phosphatases II 226-347 1.5e-23 79.4 In-house 125-303 (307) alignment 
Range on Protein: 226-347
Range on HMM: 125-303/307.0
DVLEEFGIKYILNVTPNLPNLFE--------------------------NAGEFKYKQIPISDH-----------------WSQNLSQFFPEAISFIDEA
  | | |...|...|.  .. .|                            ..... .....|.                   ......| |...||.|.
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RG------KNCGVLVHCLAGISRSVTVTVAYLMQKLN--------LSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
|       |.. ||||| ||..|. |. .|||| ..         ... .|.. ........ .|.... .| .... |
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0039614 (Phosphotyrosine protein) phosphatases II 226-346 3.3e-21 71.5 In-house 119-287 (297) alignment 
Range on Protein: 226-346
Range on HMM: 119-287/297.0
DVLEEFGIKYILNVTPNLPNLF------------------EN-----AGEFK-----------------YKQIPISDHWSQNLSQFFPEAISFIDEARG-
  . | |...|...|.  ..                    ..      . ..                 .  ... ||   .... . |.. ...||.  
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--KNCGVLVHCLAGISRSVTVTVAYLM-----QKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERT
  |.. ||||| ||..|. |. .||||      . .... .|.. ........ ...... .| |... 
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle
0040438 (Phosphotyrosine protein) phosphatases II 227-348 1e-21 73.0 In-house 105-276 (317) alignment 
Range on Protein: 227-348
Range on HMM: 105-276/317.0
VLEEFGIKYILNVTPNLPNL--------------------------FEnAGEFKYKQIPISDH----------------WSQNLSQFFPEAISFIDEARG
 . | |...|...|.  ..                           .|  ..... .....|.                  ... . . . ..|....| 
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

K----NCGVLVHCLAGISRSVTVTVAYLM-----QKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLG
.    .. ||||| ||..|. |. .||||     .. .... .|.. ........ ...... .| |... . 
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_PTPMT1_pd Subfamily PTPMT1 229-343 1.2e-14 49.1 In-house 55-164 (171) alignment 
Range on Protein: 229-343
Range on HMM: 55-164/171.0
EEFGIKYILNVTPNLPNLfenagEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKS
||. .| . | | .  .|       .. |... |.  .   .   ... ||.. . |   | ||| || .|| |.  .|||.| .||...| ...| |..
eeyelkalansteewkkl.....gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRk

NISPNFNFMGQLLDF
 |  . . . .|  .
iirlakkqwkalqey
0036941 (Phosphotyrosine protein) phosphatases II 230-347 1.3e-16 56.2 In-house 100-276 (297) alignment 
Range on Protein: 230-347
Range on HMM: 100-276/297.0
EFGIKYILNVTPNLPNLF---------------------------------------------ENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARG
| ... |...|.  .. .                                             .|  ... ... . .    .. . . . ..||...| 
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

------KNCGVLVHCLAGISRSVTVTVAYLM--------QKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
      ..  ||||| ||..|| |. .|.||           .... .|.  ..... .. ...... .| ...  |
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
0043336 (Phosphotyrosine protein) phosphatases II 232-345 6.5e-16 54.1 In-house 112-274 (278) alignment 
Range on Protein: 232-345
Range on HMM: 112-274/278.0
GIK---------------------------------------------YILNVTPNLPNLFENAGEFKYKQIPisDHWSQ-NLSQFFPEAISFIDEARGK
|..                                             . |.||..  .       . |. .|  ||    .||...     ...  . .
gvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavrealeds

NCGVLVHCLAGISRSVTVTVAYLM-----QKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
|  ||||| ||..|. |. ..||.       ..... .|.. ..... .. ...... .| ....
ngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_MSG5_pd Subfamily MSG5 233-347 1.4e-19 63.8 In-house 48-160 (165) alignment 
Range on Protein: 233-347
Range on HMM: 48-160/165.0
IKYILNVTPNLPNLFENAGEFKYKQIPIsDHWSQnLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISP
.  ..||. ....|       ||  |   .| |. . . ...  . |  |. |.  .||||  |.||| .. |||.|.  |||..|||| .| .  .|||
fdlvinvakeindlellvpavkyyhiew.ehdsk.ivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddisp

NFNFMGQLLDFERTL
.. .. ||...| .|
siglifqlmeweval
0051299 (Phosphotyrosine protein) phosphatases II 234-335 3.3e-11 38.7 In-house 164-273 (288) alignment 
Range on Protein: 234-335
Range on HMM: 164-273/288.0
KYILNVTPN----LPNLFENAGEFKYKQIPisDHWSQ-NLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLM-----QKLNLSMNDAYDIV
.. | ||..     ..   .   | |...|  ||    ......     ...  . ... |.||| ||..|. |. ...|.     ..  ... .|.  .
vrtlevtnldlldgdgesrtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrl

KMKKSNISPNFN
.... .. ....
reqRpgmvqtpe
subfamily_Laforin_pd Subfamily Laforin 235-319 2.6e-06 20.4 In-house 60-143 (183) alignment 
Range on Protein: 235-319
Range on HMM: 60-143/183.0
YILNVTPNLPNLFENAGeFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDA
|  |.   | .|. . | . |  .|. |  ...  . .|.|. ..     |   | ||| ||. || .. . .|.  |. |..  
ynenlpitlkklykeeg.layiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakv
0038934 (Phosphotyrosine protein) phosphatases II 244-346 1.1e-20 69.6 In-house 72-175 (194) alignment 
Range on Protein: 244-346
Range on HMM: 72-175/194.0
PNLFENAGeFKYKQIPISDHWS----QNLSQFFPEAISFIDEARgkNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQ
|..||.|| ..| ..|. |...    ..| .|.  .  |..|    .. |.||| ||..|. |. .|||...|..|...|......|. .. || ... .
peefekag.ieylklpfpddgtvPsleillrfldlvdeflnedp..ggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdylea

LLDFERT
|| . ..
llkryke
0046845 (Phosphotyrosine protein) phosphatases II 244-331 3.8e-10 35.1 In-house 161-257 (284) alignment 
Range on Protein: 244-331
Range on HMM: 161-257/284.0
PNLFENAGEFKYKQIPisDHWSQNLSQFFPEAISFIDEARGK---NCGVLVHCLAGISRSVTVTVAYLMQKL--------NLSMNDAYDIVKMKKSNIS
..       | |...|  ||     .. . | . ...|.. .   .. ..||| ||..|. |. ...|. ..        .... .|.  ..... .  
tgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmv
0047943 (Phosphotyrosine protein) phosphatases II 253-341 3.3e-12 41.9 In-house 171-265 (273) alignment 
Range on Protein: 253-341
Range on HMM: 171-265/273.0
FKYKQIPisDHWSQNLSQFFPEAISFIDEARG---KNCGVLVHCLAGISRSVTVTVAYLM-----QKLNLSMNDAYDIVKMKKSNISPNFNFMGQLL
| |. .|  ||      . . | | ....|.    .|  |.||| ||..|. |. ...|.      . .... .|.  ..... .. ...... .| 
fhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly
0050432 (Phosphotyrosine protein) phosphatases II 255-333 1e-09 33.7 In-house 204-284 (308) alignment 
Range on Protein: 255-333
Range on HMM: 204-284/308.0
YKQIPisDHWSQNLSQFFPEAISFIDEARgKNCGVLVHCLAGISRSVTVTVAYLM-----QKLNLSMNDAYDIVKMKKSNISPN
|.  |  ||   .  . . . . .... . ... ..||| ||..|. |. ...|.     .. .... .|.  ..... .  ..
ytnWp..dhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqt
subfamily_PTEN_pd Subfamily PTEN 255-326 4.3e-06 21.8 In-house 82-155 (184) alignment 
Range on Protein: 255-326
Range on HMM: 82-155/184.0
YKQIPISDHWSQNLS---QFFPEAISFIDEARgkNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMN-DAYDIVKMK
 ...|..|| . .|.   ..  .. ....| .  .  | ||| ||  |. ...||||...| |. . .| .. . .
vavypfdDhnppplelleeivediekwleedk..knvvvvHCkaGkGRtGvlivayllkslllekaeealelfaea
0048567 (Phosphotyrosine protein) phosphatases II 268-341 4e-08 27.8 In-house 56-132 (157) alignment 
Range on Protein: 268-341
Range on HMM: 56-132/157.0
LSQFFPEAISFIDEARGKNCGVLVHCLAGI---SRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLL
| .|.  . .|..  . ... . ||| ||    .|..|.  .||. .|... ..|......   .. |    .  |.
lyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasylls
PTPc_DSPc_SM00012 273-323 1.3e-06 24.0 In-house 20-79 (105) alignment 
Range on Protein: 273-323
Range on HMM: 20-79/105.0
PEAISFIDEARGKNC------GVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDI---V
 . ...... . ..        |.||| ||..|. |....... . . . .. .||   |
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqiv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 273-317 5.4e-06 20.6 In-house 196-241 (307) alignment 
Range on Protein: 273-317
Range on HMM: 196-241/307.0
PEAISFIDEARGKNCGVLVHCLAGISRSVT-VTVAYLMQKLNLSMN
  || ...  |...  |.||| ||. || | |.......|.   .|
ltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGin
Y_phosphatase Protein-tyrosine phosphatase 274-324 5.9e-06 21.2 Pfam-A 154-210 (235) alignment 
Range on Protein: 274-324
Range on HMM: 154-210/235.0
EAISFIDEARGKN----CGVLVHCLAGISRSVT-VTVAYLMQKLNL-SMNDAYDIVK
. ...|.. . ..      |.||| ||..|. | |.. .|...|.  .  | ..|||
slldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivk
Y_phosphatase Protein-tyrosine phosphatase 274-324 5.9e-06 21.2 In-house 154-210 (235) alignment 
Range on Protein: 274-324
Range on HMM: 154-210/235.0
EAISFIDEARGKN----CGVLVHCLAGISRSVT-VTVAYLMQKLNL-SMNDAYDIVK
. ...|.. . ..      |.||| ||..|. | |.. .|...|.  .  | ..|||
slldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivk