Gene DUSP6 in Homo sapiens

Synonym: HH19, MKP3, PYST1, DUSP6

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP6
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP029_AA protein Get Run
HsapP029_AA_204-348 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 20-142 1.7e-16 52.7 Pfam-A 2-113 (113) alignment
Range on Protein: 20-142
Range on HMM: 2-113/113.0
VAWLNEQLelGNERLLLMDCRPQELYESSHIESAINVAIPGImlrrlqkgnLPVRALFTRGEDRDRFTRRCG----TDTVVLYDesSSDWNENTGGESVL
  .| |.|  ..|...|.|.|..| |. .||. |.||. . .          | |.||.. .  . . ..       .|||.|.  .|... .......|
akelkell..ekekvvllDvRspeeyakghIpgAvnvpldsl.........yprrdlffkdklaeeleesgkkldkdktvvvyc..rsgnrsggaaalll

GLLLKKLKDEgcRAFYLEGGFSKFQAE
 |.||.|  .  . ..|.|||....||
alilkelgyk..nvyvLdGGfeawkae

PTEN_1 192-347 1e-33 111.8 In-house 28-191 (196) alignment
Range on Protein: 192-347
Range on HMM: 28-191/196.0
TDSDGSPLSNSQPSFpvEILPFLYLGCAKDS-TNLDVLEEFGIKYILNVTPNLPN-------LFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEAR
  .. .  ..  .    || ..||.| .||   .|| |.| ||  ..|...  ..        ..... ..|...|| ||. ..||..| .. |||. ..
riiamgkapsrpllq..eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewll

GKNC--GVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
 ...   ||||| ||..||.||  ||||.| .|....| ..|. | ....||  .. .|| ... |
sdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael

subfamily_DSP6_pd Subfamily DSP6 198-350 6.9e-85 276.4 In-house 5-157 (158) alignment
Range on Protein: 198-350
Range on HMM: 5-157/158.0
PLSNSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGI
 |.... .|||||||.||||.|||..||.||....|||.||||.|||| ||..||.||.||||.||.||||..||||||.|||||| |...|||||||||
klkkaeaefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGi

SRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGLS
|||||||.||||.||.||.|||||.||..|||||||||||||||||||.|.||
srsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrls

0044763 (Phosphotyrosine protein) phosphatases II 201-348 2e-42 140.2 In-house 17-171 (178) alignment
Range on Protein: 201-348
Range on HMM: 17-171/178.0
NSQPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGE-------FKYKQIPISDHWSQNLSQFFPEAISFIDEAR-GKNCGVLVH
 |..  ..||||.||||.. .. .|. | | ||..|.|.|..|.. |..  .       ..|..|||.||  ..|...|.|.. ||.||.  |.. ||||
rsdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVH

CLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSnISPNFNFMGQLLDFERTLG
| ||..|| |. .|||| ||.||...|.. |..... |.||.... ||..||. | 
CsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll

subfamily_LRR-DSP_pd Subfamily LRR-DSP 203-347 1.1e-35 117.0 In-house 116-258 (263) alignment
Range on Protein: 203-347
Range on HMM: 116-258/263.0
QPSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAgeFKYKQI-PISDHWSQNLSQFFPEAISFIDEARgKNCGVLVHCLAGISRSV
. | | ||.. |.||. . ..|  .|.. |. .||    ..  || .   |||  |  | |    ..||.| |  .||.| | |. |||||| ||.||| 
vssvPdeiidklflGgldsannksilkdlgvthillavadfePlfPkl..fkylsiddiedvdeadisqhfeetnafieeGr.kkGGvlvhcraGvsrss

TVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
|....|||.| .| ...|.|.|. |...| ||  |. ||. .|. |
tlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl

subfamily_DSP1_pd Subfamily DSP1 204-349 5.8e-48 157.0 In-house 13-158 (163) alignment
Range on Protein: 204-349
Range on HMM: 13-158/163.0
PSF-PVE-ILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENagEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSV
. . ||| ||.||||| .....||..|.. ||  ||||. .|.| ||.   |.||.....|. ....|. | |.| ||||.. ||  ||.|| |||||| 
klydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRss

TVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLGL
|. .||||.. ..|...|.| || ..| ||||..|..|||..|..|.|
tlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklll

0048179 (Phosphotyrosine protein) phosphatases II 204-346 2.1e-38 126.6 In-house 1-143 (144) alignment
Range on Protein: 204-346
Range on HMM: 1-143/144.0
PSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTV
||.|.|||| ||||.  .. .|. | ..||....|.|.. .. |.    ..| ..|. ||   .|.....|.. ||.||. ... ||||| ||..|. |.
psnpseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtl

TVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERT
 .|||| ||.||...|.. |... ... ||.... .||..|. 
vaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl

0048076 (Phosphotyrosine protein) phosphatases II 204-346 1.6e-37 123.7 In-house 1-141 (145) alignment
Range on Protein: 204-346
Range on HMM: 1-141/145.0
PSFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFenAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTV
|..| |||| ||||.  .  .|. |...||...||.|..|..|.  .  ..| ..|. ||  ..|.....|.. ||.||. ... ||||| ||..|. |.
pywpseilpglylgslptaldlellkdlgittvlnltselelle..rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtl

TVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERT
 .|||| .|..|. .|.. |... ... ||.... .|..||. 
vaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefele

subfamily_STYXL1_pd Subfamily STYXL1 204-347 1.2e-28 93.3 In-house 8-153 (157) alignment
Range on Protein: 204-347
Range on HMM: 8-153/157.0
PSFPVEILP-FLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGE-FKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSV
...|||.|| .||||  |...|  . ... .|  .||. .  .|..   .  |  .|...|.   .| ... ||..||.. . ..  |||    |||||.
ktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsa

TVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
.| .|||| . ......||. .|  |.|. || .|. || ..|..|
aviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql

0045098 (Phosphotyrosine protein) phosphatases II 204-347 1.7e-28 95.2 In-house 19-271 (278) alignment
Range on Protein: 204-347
Range on HMM: 19-271/278.0
PSFPVEILPFLYLGCAK-----------------------------------------DSTNLDVLEEFGIKYILNVTPNL-------------------
...| ||.|.||||...                                          . ... | | ||..|...|. .                   
lgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslty

-----------------------------PNLFENAGEFKYKQIPISDHWSQNLS--QFFPEAISFIDEARG--------------KNCGVLVHCLAGIS
                             .. .|..| . .. .|. || . .|.  ..| |.. ||.||.               ... ||||| ||..
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RSVTVTVAYLMQKL---NLSMNDAYDIVKMKKSN-ISPNFNFMGQLLDFERTL
|. |. .|||| .|   .... .|.. ..... . . .|.... .| .|.. |
RtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel

subfamily_Slingshot_pd Subfamily Slingshot 205-347 3.4e-35 114.9 In-house 17-157 (169) alignment
Range on Protein: 205-347
Range on HMM: 17-157/169.0
SFPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFEnaGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVT
  . .|  ..|||   ...||. |.| |..|||||| .. | |.  ..|.|..| . |. ...| ... |. .||..|. |.  |||||  |.||| .. 
dsaskifdhvylGsewnasnleelkengveyilnvtkeidnffp..ekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastv

VAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
.|| |.. .||...|.. || ..| | || .|. ||  .|  |
iayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGil

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 205-345 2.1e-30 99.2 In-house 5-145 (148) alignment
Range on Protein: 205-345
Range on HMM: 5-145/148.0
SFPVEILP-FLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAGeFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTV
 || || . ||.||  |  ..|..|...|.  | | | . .| ... |  .| .....|.  ..||..|...|.|...|...   ||||.  |.|||  .
tfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrg.ieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssal

TVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
....|..  . |...|...|| |.  . ||  |. || ..|.
allwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq

subfamily_DSP8_pd Subfamily DSP8 206-348 1.5e-46 151.9 In-house 14-155 (159) alignment
Range on Protein: 206-348
Range on HMM: 14-155/159.0
FPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLfENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTV
 | .||..||||. ||. . ..|.. || |.||.  . |.| |   | |. ..|. |. . .|...|.....||| |. .|. ||||.||||||| || .
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkl.eelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvai

AYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLG
||.|..|..|...||  || |.  ||||.||.||||..|..| 
ayimktlemsldeayrfvkekrptispnlnflgqLleyekelk

0043147 (Phosphotyrosine protein) phosphatases II 206-347 1e-35 118.3 In-house 18-160 (172) alignment
Range on Protein: 206-347
Range on HMM: 18-160/172.0
FPVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPN-LPNLFENAGEFKYKQIPISDHWSQnLSQFFPEAISFIDE--ARGKNCGVLVHCLAGISRSVT
 | ..........  .. ... | | ||..|.|.|.  ..  ..    ..|  .|. ||. . |.....|...||||  |. ... ||||| ||..|..|
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

VTVAYLMQkLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
. .||||. |.||. .|.. |..|......|.... .|..||..|
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll

0041856 (Phosphotyrosine protein) phosphatases II 206-347 1.8e-33 111.1 In-house 18-172 (182) alignment
Range on Protein: 206-347
Range on HMM: 18-172/182.0
FPVEILPFLYLGCAKD--------------STNLDVLEEFGIKYILNVTpnL----PNLFENAGeFKYKQIPISDHWSQNlsqfFPEAISFIDEARGKNC
.. .|.. ||||. ..                .|. | | ||..|.|.|       |.|.|..| ..|...|. ||   .    ..|...||.|.. ...
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlg.iqylylpwpDhgvpd....ldelldfieevleegg

GVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKS--NISPNFNFMGQLLDFERTL
 ||||| ||..|. |. .|||| ||..|. .|.. |.....   |.||..|. ||. .|. |
pvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll

0046846 (Phosphotyrosine protein) phosphatases II 206-346 5.5e-30 99.8 In-house 11-171 (176) alignment
Range on Protein: 206-346
Range on HMM: 11-171/176.0
FPVEILPFLYLGCAK----------DSTNLDVLEEFGIKYILNVT----------PNLPNLFENAGEfKYKQIPISDHWSQNLsQFFPEAISFIDEARGK
....|.. |.||..             ..|. | | ||....|.|          ||.....|..|  .|...|. ||.  .| . ..|.. ||.||. .
dldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.qylhlpwpDhgvpdl.elllellefirealke

NCGVLVHCLAGISRSVTVTVAYLMQK-LNLSMNDAYDIVKMKKS-NISPNFNFMGQLLDFERT
.  ||||| |||.|. |. .|||...  .||...|.. |..... .. ...... .| .||. 
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell

subfamily_MKPLT_pd Subfamily MKPLT 206-345 5.4e-27 88.3 In-house 20-158 (164) alignment
Range on Protein: 206-345
Range on HMM: 20-158/164.0
FPVEILP-FLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAgeFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVT
.|  .|.  |||| ||..||  ||..  |..|.||. .  . | ..  ..| |. ..|   ..||.|.  |  |. .|      |||||  | ||| .||
ypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpks..veYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvt

VAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
||.|..     ...||. .| ..| ..||  |. ||  ||.
vafLikskgwtlkeayeylkerrsivapnrGflkqlakfee

subfamily_MKPLV_pd Subfamily MKPLV 206-345 5.4e-27 88.3 In-house 20-158 (164) alignment
Range on Protein: 206-345
Range on HMM: 20-158/164.0
FPVEILP-FLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENAgeFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVT
.|  .|.  |||| ||..||  ||..  |..|.||. .  . | ..  ..| |. ..|   ..||.|.  |  |. .|      |||||  | ||| .||
ypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpks..veYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvt

VAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
||.|..     ...||. .| ..| ..||  |. ||  ||.
vafLikskgwtlkeayeylkerrsivapnrGflkqlakfee

subfamily_DSP10_pd Subfamily DSP10 207-347 5.7e-61 199.0 In-house 14-153 (159) alignment
Range on Protein: 207-347
Range on HMM: 14-153/159.0
PVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENaGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVA
 ...||||.|| .||...||.|....|...||||...|| ||.  ..|||.||.||  .|||.| | ||. ||.||| |.  ||||| ||||||.||..|
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
|||..||||.||||. || |.. ||||.|||||||.||..|
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekel

PTPc_motif_SM00404 207-345 1.7e-45 149.4 In-house 2-139 (140) alignment
Range on Protein: 207-345
Range on HMM: 2-139/140.0
PVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLfENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVA
| .||| |||| .....|...|...||....||| . ..  ..  .|...|||..|. ...||........||..|. |.. ||||| ||.|||.|...|
psrilphlylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
|||.. .||...||..|| ....||||.||. ||...|.
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyek

0049260 (Phosphotyrosine protein) phosphatases II 207-347 2e-32 107.4 In-house 8-149 (152) alignment
Range on Protein: 207-347
Range on HMM: 8-149/152.0
PVEILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFE-NAGEFKYKQIPISDHWSQNLSQFFPEAISFIDE-ARGKNCGVLVHCLAGISRSVTVT
| |.......|.   . ... | | ||..|...|  |.. ..  .  ..|...|. ||. ..|||...... ||.. |. |.. ||||| ||..|. |. 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

VAYLMQkLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
.||||  |..|. .|.. |..|.... ||.... .|..||..|
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll

0037934 (Phosphotyrosine protein) phosphatases II 207-346 8.1e-27 89.8 In-house 39-240 (243) alignment
Range on Protein: 207-346
Range on HMM: 39-240/243.0
PVEILPFLYLGCA--------KDSTNLDVLEEFGIKYILNVTPNL------------------------------------------PN-LFENAGEFKY
 ....| |.....        .. .... | | ||..|...|.                                            ..   .    ..|
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

KQIPISDH---W-SQNLSQFFPEAISFIDE-----ARGKNCGVLVHCLAGISRSVTVTVAYLMQKL-NLSMNDAYDIVKMKKSN-ISPNFNFMGQLLDFE
 ..|. ||      ..| .|. |...||.|     |. ..  ||||| ||..|. |. .|||| .| .... .|.. ....... . ...... .| ...
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal

RT
. 
le

subfamily_DSP14_pd Subfamily DSP14 208-347 1.3e-33 110.1 In-house 8-144 (157) alignment
Range on Protein: 208-347
Range on HMM: 8-144/157.0
VEILPFLYLGcAKDSTNLDVLEEFGIKYILNVTPNLPNlfENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAY
..| | |.|. .  ... ..|.. .|  |.|||..|||  ... .... ..|..|. ...|...| |..  |.|.. |.  .|||| ||.||| ....||
sqitpsLfls.gvaalskellkkkkitliinvtvelpn..tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

LMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
||.  .||...|| .|| ... |.||  |  || |.|. |
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkkl

0036282 (Phosphotyrosine protein) phosphatases II 208-347 7.3e-30 99.3 In-house 13-169 (174) alignment
Range on Protein: 208-347
Range on HMM: 13-169/174.0
VEILPFLYLGCAKDStNLDVLEEFGIKYILNVTPNLPN-------------LFENAGEFKYKQIPISDHWSQNLSQfFPEAISFIDEARGK--NCGVLVH
..|.| |..|..  . ... | |.||........  ..              ..    ..|...|. ||   .||. . |...|..||. .  .. ||||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CLAGISRSVTVTVAYLMQKLNL-SMNDAYDIVKMKK---SNISPNFNFMGQLLDFERTL
| ||..|. |. .|||| .. | |. ||.|.|....   ... ...... .| .||. |
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll

subfamily_DSP12_pd Subfamily DSP12 209-346 6.8e-39 127.7 In-house 4-142 (155) alignment
Range on Protein: 209-346
Range on HMM: 4-142/155.0
EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPN-LPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAY
.||| |||| ... .. . |.|..|. .| |. . ||.  ...|. ..|.|.| |. .... ....||..||.||. ..  ||||| ||.|||||. .||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERT
||.| .||...|...|| ||..|.|| .|. ||  ||. 
lmkkeklslekAlklvkekkpeiepNegFleQLklfekm

subfamily_DSP19_pd Subfamily DSP19 209-346 1.5e-38 126.5 In-house 14-149 (152) alignment
Range on Protein: 209-346
Range on HMM: 14-149/152.0
EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENagEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYL
|. | ||||     .. . |.| .| .||||. ..||.| .  .|.|..|.| |.  ..|.....||. ||.||| |.  ||||| ||.|||..| .|||
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpk..dftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviayl

MQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERT
|.| .||...|.. |. .. .|.||  |. || ..| .
mkkeelsleealelvrearpcikPneGFikqLkeyeae

subfamily_DSP15_pd Subfamily DSP15 209-346 7.3e-38 124.0 In-house 4-138 (151) alignment
Range on Protein: 209-346
Range on HMM: 4-138/151.0
EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENageFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYL
..|| ||||  .|| . . |.|  |  ||.|  |  .|...   ..|| |..||  |..||.|| |...|| ..| |. .||||||||.|||||..||||
kvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd...ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERT
|  ..|. .|| ...|...|   ||| |  || ..|.|
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt

subfamily_DSP3_pd Subfamily DSP3 209-347 8.6e-29 94.3 In-house 13-157 (162) alignment
Range on Protein: 209-347
Range on HMM: 13-157/162.0
EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTPN-L-----PNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGK-NCGVLVHCLAGISRSV
|. | ||.| .. ... . |...|| ..|| .   .      . | .  |.||  ....|  . .||..| .| .|||||  . .  ||||| .|.||| 
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

TVTVAYLMQKLNLSMNDAYDIVKMKKsNISPNFNFMGQLLDFERTL
|. .|||| . ......|   |..|. .| ||  |. || .... |
tlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeel

0051082 (Phosphotyrosine protein) phosphatases II 209-342 5.6e-25 83.1 In-house 10-148 (151) alignment
Range on Protein: 209-342
Range on HMM: 10-148/151.0
EILPFLYLGCAKDSTNLDVLEEFGIKYILNVTP-----NLPNLFENAGeFKYKQIPISDHWSQNLSQFFPEAISFIDEARGK-NCGVLVHCLAGISRSVT
 . ..||.. .  . .|. |.| |||.|.|...     ..|......| .....||| |.. ..|...|.....|..... | |  ||||| ||..|. |
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelg.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

VTVAYLMQkLNLSMNDAYDIVKMKKS-NISPNFNFMGQLLD
. ..|||  |..|...|.. ...|    . ||  |. ||..
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa

0042113 (Phosphotyrosine protein) phosphatases II 209-345 4.4e-24 80.7 In-house 49-240 (245) alignment
Range on Protein: 209-345
Range on HMM: 49-240/245.0
EILPFLYLGCAKDSTNLD----VLEEFGIKYILNVTPNLP--------------------------------------------NLFENAGEFKYKQIPI
.| | .... .  . ...     | | ||..|...|.  .                                              .|    . | ..|.
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

SDHWSQNLSQFFPEAISFIDEARG--KNCGVLVHCLAGISRSVTVTVAYLM-----QKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
 ||   .|.. . ....|...|.   .|  ||||| ||..|. |. .||||       |..|. .|.. ........ ...... .| ....
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

subfamily_STYX_pd Subfamily STYX 209-345 6.8e-23 74.6 In-house 14-155 (166) alignment
Range on Protein: 209-345
Range on HMM: 14-155/166.0
EILPFLYLGC--AKDSTNLDVLEEFGIKYILNVTPNLPNLFE---NAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTV
|||| |.||   |   . |.||.. || .|. .  |.   .       .|.|  . ..|   .|. ...|.  .|||..  |   ||||  |||||| ..
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

TVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
 .||.|.   |   .|.  |. ..  |.||  |. || ..| 
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyea

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 213-346 5.6e-26 84.7 In-house 9-151 (154) alignment
Range on Protein: 213-346
Range on HMM: 9-151/154.0
FLYLGCAKDSTNLDVLEEFGIKYILNVTPNLPNLFENA-------GEFKYKQIPISDHWSQNLSQFFPEAISFIDEAR--GKNCGVLVHCLAGISRSVTV
|||..  . . |   |..  || ||||    .||| .          ..| .. . |.  ... . .  |  |||.|    .| .||||. .|.||| ..
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

TVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERT
 ..|||.||..|.  |. ..|  .  |.||  |. ||  ||. 
lisylmdklkislslalellkdsryiikPnqGflkqleifeke

DSPc Dual specificity phosphatase, catalytic domain 214-345 2.9e-44 145.2 Pfam-A 1-132 (133) alignment
Range on Protein: 214-345
Range on HMM: 1-132/133.0
LYLGCAKDSTnLDVLEEFGIKYILNVTPNLPN-LFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKL
|||| ..... |..||..||....||| . ||  . . .|..| .||. |......|....||..||..|. |.. ||||| |||||| |...||||.. 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
|||.|.||..|| ..|.||||..|..|||..||
nlslneAyefvkerrskispnagflrqLleyer

DSPc Dual specificity phosphatase, catalytic domain 214-345 2.9e-44 145.2 In-house 1-132 (133) alignment
Range on Protein: 214-345
Range on HMM: 1-132/133.0
LYLGCAKDSTnLDVLEEFGIKYILNVTPNLPN-LFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKL
|||| ..... |..||..||....||| . ||  . . .|..| .||. |......|....||..||..|. |.. ||||| |||||| |...||||.. 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
|||.|.||..|| ..|.||||..|..|||..||
nlslneAyefvkerrskispnagflrqLleyer

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 214-347 2.4e-26 85.6 In-house 6-141 (145) alignment
Range on Protein: 214-347
Range on HMM: 6-141/145.0
LYLGCAKDSTNLDVLEEFGIKYILNVTP--NLPNLFENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQK
|| | |  . .. .|.|.||  |.|..    .     .. ...   |  .|  | .||| | |   |||  . .  ||.|||.||.||||||.||.||. 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

LNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
 |... .|   |. ..    || .|. .||..|. |
cnmtlseaarqvrsnrllaypnvtflknllnlekql

0051429 (Phosphotyrosine protein) phosphatases II 218-345 2.4e-18 62.2 In-house 28-222 (272) alignment
Range on Protein: 218-345
Range on HMM: 28-222/272.0
CAK---DSTNLDVLEEFGIKYILNVTPNL----PNLFENAGEFKYKQIPISDHWSQNLSQFF--------------------------------------
 .    .  ... |.| |||.|.....       . .  .  ..| ..|| |.  .  ....                                      
ggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhy

----------PEAISFIDEARGkNCGVLVHCLAGISRSVTVTVAYLMQkLNLS--------------MNDAYDIVKMKKSNISPNFNFMGQLLDFER
           . ...... .  .  ||||| ||..|. || ...|.  |..|              . .|.. .. .  .. ..  .. .|.....
tdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeall

subfamily_DSP23_pd Subfamily DSP23 223-325 2.4e-11 38.5 In-house 22-123 (148) alignment
Range on Protein: 223-325
Range on HMM: 22-123/148.0
TNLDVLEEFGIKYILNVTPNLPNLFENAGEFKYKQIPISDHWSQNLSQFfPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDI
 ..  | . |..|.. .| . .   | . .  .... | |.    | |   | .  ..||  ||  | |||| |  |. |.   ||... .|.  .|   
dqyrylldlgvrylvslteegrphveatpnltlvrlriddyhppaleqv.vefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiae

VKM
|. 
vrr

0040439 (Phosphotyrosine protein) phosphatases II 224-347 5.9e-26 87.0 In-house 70-245 (249) alignment
Range on Protein: 224-347
Range on HMM: 70-245/249.0
NLDVLEEFGIKYILNVTPNLPNLF-----------------------------------------ENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEA
... | | ||..|...|.  .. .                                         ..  ......|.. |   ......|.....||...
fwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieav

RG------KNCGVLVHCLAGISRSVTVTVAYLM-----QKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
|       |.. ||||| ||..|. |. .||||      .|.... .|.. ........ .|.... .|..... |
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

0049772 (Phosphotyrosine protein) phosphatases II 225-347 2.8e-31 104.8 In-house 163-273 (314) alignment
Range on Protein: 225-347
Range on HMM: 163-273/314.0
LDVLEefgikyilnvtPNL--PNLFENAGeFKYKQIPISDhWSQNLSQFFPEAISFIDEArGKNCGVLVHCLAGISRSVT-VTVAYLMQKLNLSMNDAYD
|. |.           . |  |.|||..| .||..||..| .|..|...|.|.. ||.||  |.  ||||| ||..|. | |..|||| .|..|...|..
lellk...........eelydpelferlg.ikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleeale

IVKMKKSnISPNFNFMGQLLDFERTL
 |..| . |.||..|. ||...|  |
dvrlkRp.inpnpgfieqleqyefil

0045450 (Phosphotyrosine protein) phosphatases II 226-347 1.5e-23 79.4 In-house 125-303 (307) alignment
Range on Protein: 226-347
Range on HMM: 125-303/307.0
DVLEEFGIKYILNVTPNLPNLFE--------------------------NAGEFKYKQIPISDH-----------------WSQNLSQFFPEAISFIDEA
  | | |...|...|.  .. .|                            ..... .....|.                   ......| |...||.|.
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RG------KNCGVLVHCLAGISRSVTVTVAYLMQKLN--------LSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
|       |.. ||||| ||..|. |. .|||| ..         ... .|.. ........ .|.... .| .... |
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

0039614 (Phosphotyrosine protein) phosphatases II 226-346 3.3e-21 71.5 In-house 119-287 (297) alignment
Range on Protein: 226-346
Range on HMM: 119-287/297.0
DVLEEFGIKYILNVTPNLPNLF------------------EN-----AGEFK-----------------YKQIPISDHWSQNLSQFFPEAISFIDEARG-
  . | |...|...|.  ..                    ..      . ..                 .  ... ||   .... . |.. ...||.  
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealae

--KNCGVLVHCLAGISRSVTVTVAYLM-----QKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERT
  |.. ||||| ||..|. |. .||||      . .... .|.. ........ ...... .| |... 
lpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle

0040438 (Phosphotyrosine protein) phosphatases II 227-348 1e-21 73.0 In-house 105-276 (317) alignment
Range on Protein: 227-348
Range on HMM: 105-276/317.0
VLEEFGIKYILNVTPNLPNL--------------------------FEnAGEFKYKQIPISDH----------------WSQNLSQFFPEAISFIDEARG
 . | |...|...|.  ..                           .|  ..... .....|.                  ... . . . ..|....| 
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

K----NCGVLVHCLAGISRSVTVTVAYLM-----QKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTLG
.    .. ||||| ||..|. |. .||||     .. .... .|.. ........ ...... .| |... . 
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

subfamily_PTPMT1_pd Subfamily PTPMT1 229-343 1.2e-14 49.1 In-house 55-164 (171) alignment
Range on Protein: 229-343
Range on HMM: 55-164/171.0
EEFGIKYILNVTPNLPNLfenagEFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKS
||. .| . | | .  .|       .. |... |.  .   .   ... ||.. . |   | ||| || .|| |.  .|||.| .||...| ...| |..
eeyelkalansteewkkl.....gveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRk

NISPNFNFMGQLLDF
 |  . . . .|  .
iirlakkqwkalqey

0036941 (Phosphotyrosine protein) phosphatases II 230-347 1.3e-16 56.2 In-house 100-276 (297) alignment
Range on Protein: 230-347
Range on HMM: 100-276/297.0
EFGIKYILNVTPNLPNLF---------------------------------------------ENAGEFKYKQIPISDHWSQNLSQFFPEAISFIDEARG
| ... |...|.  .. .                                             .|  ... ... . .    .. . . . ..||...| 
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

------KNCGVLVHCLAGISRSVTVTVAYLM--------QKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFERTL
      ..  ||||| ||..|| |. .|.||           .... .|.  ..... .. ...... .| ...  |
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel

0043336 (Phosphotyrosine protein) phosphatases II 232-345 6.5e-16 54.1 In-house 112-274 (278) alignment
Range on Protein: 232-345
Range on HMM: 112-274/278.0
GIK---------------------------------------------YILNVTPNLPNLFENAGEFKYKQIPisDHWSQ-NLSQFFPEAISFIDEARGK
|..                                             . |.||..  .       . |. .|  ||    .||...     ...  . .
gvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavrealeds

NCGVLVHCLAGISRSVTVTVAYLM-----QKLNLSMNDAYDIVKMKKSNISPNFNFMGQLLDFER
|  ||||| ||..|. |. ..||.       ..... .|.. ..... .. ...... .| ....
ngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

subfamily_MSG5_pd Subfamily MSG5 233-347 1.4e-19 63.8 In-house 48-160 (165) alignment
Range on Protein: 233-347
Range on HMM: 48-160/165.0
IKYILNVTPNLPNLFENAGEFKYKQIPIsDHWSQnLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISP
.  ..||. ....|       ||  |   .| |. . . ...  . |  |. |.  .||||  |.||| .. |||.|.  |||..|||| .| .  .|||
fdlvinvakeindlellvpavkyyhiew.ehdsk.ivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddisp

NFNFMGQLLDFERTL
.. .. ||...| .|
siglifqlmeweval

0051299 (Phosphotyrosine protein) phosphatases II 234-335 3.3e-11 38.7 In-house 164-273 (288) alignment
Range on Protein: 234-335
Range on HMM: 164-273/288.0
KYILNVTPN----LPNLFENAGEFKYKQIPisDHWSQ-NLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLM-----QKLNLSMNDAYDIV
.. | ||..     ..   .   | |...|  ||    ......     ...  . ... |.||| ||..|. |. ...|.     ..  ... .|.  .
vrtlevtnldlldgdgesrtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrl

KMKKSNISPNFN
.... .. ....
reqRpgmvqtpe

subfamily_Laforin_pd Subfamily Laforin 235-319 2.6e-06 20.4 In-house 60-143 (183) alignment
Range on Protein: 235-319
Range on HMM: 60-143/183.0
YILNVTPNLPNLFENAGeFKYKQIPISDHWSQNLSQFFPEAISFIDEARGKNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDA
|  |.   | .|. . | . |  .|. |  ...  . .|.|. ..     |   | ||| ||. || .. . .|.  |. |..  
ynenlpitlkklykeeg.layiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakv

0038934 (Phosphotyrosine protein) phosphatases II 244-346 1.1e-20 69.6 In-house 72-175 (194) alignment
Range on Protein: 244-346
Range on HMM: 72-175/194.0
PNLFENAGeFKYKQIPISDHWS----QNLSQFFPEAISFIDEARgkNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQ
|..||.|| ..| ..|. |...    ..| .|.  .  |..|    .. |.||| ||..|. |. .|||...|..|...|......|. .. || ... .
peefekag.ieylklpfpddgtvPsleillrfldlvdeflnedp..ggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdylea

LLDFERT
|| . ..
llkryke

0046845 (Phosphotyrosine protein) phosphatases II 244-331 3.8e-10 35.1 In-house 161-257 (284) alignment
Range on Protein: 244-331
Range on HMM: 161-257/284.0
PNLFENAGEFKYKQIPisDHWSQNLSQFFPEAISFIDEARGK---NCGVLVHCLAGISRSVTVTVAYLMQKL--------NLSMNDAYDIVKMKKSNIS
..       | |...|  ||     .. . | . ...|.. .   .. ..||| ||..|. |. ...|. ..        .... .|.  ..... .  
tgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmv

0047943 (Phosphotyrosine protein) phosphatases II 253-341 3.3e-12 41.9 In-house 171-265 (273) alignment
Range on Protein: 253-341
Range on HMM: 171-265/273.0
FKYKQIPisDHWSQNLSQFFPEAISFIDEARG---KNCGVLVHCLAGISRSVTVTVAYLM-----QKLNLSMNDAYDIVKMKKSNISPNFNFMGQLL
| |. .|  ||      . . | | ....|.    .|  |.||| ||..|. |. ...|.      . .... .|.  ..... .. ...... .| 
fhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly

0050432 (Phosphotyrosine protein) phosphatases II 255-333 1e-09 33.7 In-house 204-284 (308) alignment
Range on Protein: 255-333
Range on HMM: 204-284/308.0
YKQIPisDHWSQNLSQFFPEAISFIDEARgKNCGVLVHCLAGISRSVTVTVAYLM-----QKLNLSMNDAYDIVKMKKSNISPN
|.  |  ||   .  . . . . .... . ... ..||| ||..|. |. ...|.     .. .... .|.  ..... .  ..
ytnWp..dhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqt

subfamily_PTEN_pd Subfamily PTEN 255-326 4.3e-06 21.8 In-house 82-155 (184) alignment
Range on Protein: 255-326
Range on HMM: 82-155/184.0
YKQIPISDHWSQNLS---QFFPEAISFIDEARgkNCGVLVHCLAGISRSVTVTVAYLMQKLNLSMN-DAYDIVKMK
 ...|..|| . .|.   ..  .. ....| .  .  | ||| ||  |. ...||||...| |. . .| .. . .
vavypfdDhnppplelleeivediekwleedk..knvvvvHCkaGkGRtGvlivayllkslllekaeealelfaea

0048567 (Phosphotyrosine protein) phosphatases II 268-341 4e-08 27.8 In-house 56-132 (157) alignment
Range on Protein: 268-341
Range on HMM: 56-132/157.0
LSQFFPEAISFIDEARGKNCGVLVHCLAGI---SRSVTVTVAYLMQKLNLSMNDAYDIVKMKKSNISPNFNFMGQLL
| .|.  . .|..  . ... . ||| ||    .|..|.  .||. .|... ..|......   .. |    .  |.
lyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasylls

PTPc_DSPc_SM00012 273-323 1.3e-06 24.0 In-house 20-79 (105) alignment
Range on Protein: 273-323
Range on HMM: 20-79/105.0
PEAISFIDEARGKNC------GVLVHCLAGISRSVTVTVAYLMQKLNLSMNDAYDI---V
 . ...... . ..        |.||| ||..|. |....... . . . .. .||   |
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqiv

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 273-317 5.4e-06 20.6 In-house 196-241 (307) alignment
Range on Protein: 273-317
Range on HMM: 196-241/307.0
PEAISFIDEARGKNCGVLVHCLAGISRSVT-VTVAYLMQKLNLSMN
  || ...  |...  |.||| ||. || | |.......|.   .|
ltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGin

Y_phosphatase Protein-tyrosine phosphatase 274-324 5.9e-06 21.2 Pfam-A 154-210 (235) alignment
Range on Protein: 274-324
Range on HMM: 154-210/235.0
EAISFIDEARGKN----CGVLVHCLAGISRSVT-VTVAYLMQKLNL-SMNDAYDIVK
. ...|.. . ..      |.||| ||..|. | |.. .|...|.  .  | ..|||
slldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivk

Y_phosphatase Protein-tyrosine phosphatase 274-324 5.9e-06 21.2 In-house 154-210 (235) alignment
Range on Protein: 274-324
Range on HMM: 154-210/235.0
EAISFIDEARGKN----CGVLVHCLAGISRSVT-VTVAYLMQKLNL-SMNDAYDIVK
. ...|.. . ..      |.||| ||..|. | |.. .|...|.  .  | ..|||
slldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivk