Gene DUSP7 in Homo sapiens

Synonym: MKPX, PYST2, DUSP7

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP6
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP030_AA protein Get Run
HsapP030_AA_242-386 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 56-180 4.5e-12 38.5 Pfam-A 1-112 (113) alignment
Range on Protein: 56-180
Range on HMM: 1-112/113.0
SAEWLQEELearGGASLLLLDCRPHELFESSHIETAINLAIPGLmlrrLRKGNLPIRSIIPNHaDKERFATRCKAATVLLYDeatAEWQPEPGAPASVLG
||..|.| |   .. ...|||.|. | .. .||. |.|.. . |      .. |.... ...   .|.     |  ||..|.   .  .   || |..| 
sakelkell...ekekvvllDvRspeeyakghIpgAvnvpldsl....yprrdlffkdklaee.leesgkkldkdktvvvyc...rsgnrsggaaallla

LLLQKLRDDgcQAYYLQGGFNKFQT
|.|..|  .  . |.| |||.... 
lilkelgyk..nvyvLdGGfeawka

PTEN_1 237-385 1.1e-33 111.7 In-house 34-191 (196) alignment
Range on Protein: 237-385
Range on HMM: 34-191/196.0
VPSSQPAFPvQILPYLYLGCAKDS-TNLDVLGKYGIKYILNVTPNLPN-------AFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKC--G
...|.| .  .| . ||.| .||   .|| |.. ||  ..|...  ..        ..  . ..|...|| ||. ..||..| .. |||. ..|...   
kapsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnv

VLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
||||| ||..||.||  ||||.|..|. ..| ..|..| ....||  .. .|| ... |
VlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfael

0044763 (Phosphotyrosine protein) phosphatases II 238-386 9.7e-43 141.2 In-house 16-171 (178) alignment
Range on Protein: 238-386
Range on HMM: 16-171/178.0
PSSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGE-------FTYKQIPISDHWSQNLSQFFPEAISFIDEAR-SKKCGVLV
..|..  ...|||.||||.. .. .|. | ..||..|.|.|..|.. |..  .       ..|..|||.||  ..|...|.|.. ||.||. .|.. |||
ersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlV

HCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSnISPNFNFMGQLLDFERTLG
|| ||..|| |. .|||| |..|||..|...|..... |.||.... ||..||. | 
HCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll

subfamily_DSP6_pd Subfamily DSP6 239-388 2e-85 278.2 In-house 8-157 (158) alignment
Range on Protein: 239-388
Range on HMM: 8-157/158.0
SSQPAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRS
... .|||.|||.||||.|||..||.|| |..|||.||||.||||.||. ||..|.||||.||.||||..||||||.|||||||||..||||||||||||
kaeaefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrs

VTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGLS
||||.||||.|..||||||||.||..|||||||||||||||||||.|.||
vtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrls

0041856 (Phosphotyrosine protein) phosphatases II 240-385 2.9e-34 113.6 In-house 14-172 (182) alignment
Range on Protein: 240-385
Range on HMM: 14-172/182.0
SQPAFPVQILPYLYLGCAKD--------------STNLDVLGKYGIKYILNVTpnlpN------AFEHGGeFTYKQIPISDHWSQNlsqfFPEAISFIDE
 .. .. .|...||||. ..                .|. | ..||..|.|.|    .       .|. | ..|...|. ||   .    ..|...||.|
dhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt....eelywpellerlg.iqylylpwpDhgvpd....ldelldfiee

ARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKS--NISPNFNFMGQLLDFERTL
...... ||||| ||..|. |. .|||| |...|| .|...|.....   |.||..|. ||. .|. |
vleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll

subfamily_DSP1_pd Subfamily DSP1 242-387 9.7e-49 159.6 In-house 13-158 (163) alignment
Range on Protein: 242-387
Range on HMM: 13-158/163.0
PAF-PVQ-ILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHggEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSV
... ||. ||..|||| .....||..| . ||  ||||. .|.|.||.   |.||.....|. ....|. | |.| ||||...|.  ||.|| |||||| 
klydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRss

TVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLGL
|. .||||.. ..||..|.||||...| ||||..|..|||..|..|.|
tlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklll

0048076 (Phosphotyrosine protein) phosphatases II 242-384 9.9e-38 124.4 In-house 1-141 (145) alignment
Range on Protein: 242-384
Range on HMM: 1-141/145.0
PAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGefTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTV
| .| .|||.||||.  .  .|. | ..||...||.|..|.. ...|   .| ..|. ||  ..|.....|.. ||.||..... ||||| ||..|. |.
pywpseilpglylgslptaldlellkdlgittvlnltselellerlgi..qylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtl

TVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERT
 .|||| ....|| .|...|... ... ||.... .|..||. 
vaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefele

subfamily_Slingshot_pd Subfamily Slingshot 242-385 2.3e-36 118.8 In-house 16-157 (169) alignment
Range on Protein: 242-385
Range on HMM: 16-157/169.0
PAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEhgGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTV
 . . .|  ..|||   ...||. | . |..|||||| .. | |.  ..|.|..| . |. ...| ... |. .||..|..|.  |||||  |.||| ..
ldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffp..ekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsast

TVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
 .|| |.. .|||..|...||...| | || .|. ||  .|  |
viayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGil

subfamily_LRR-DSP_pd Subfamily LRR-DSP 242-385 3.6e-33 108.8 In-house 117-258 (263) alignment
Range on Protein: 242-385
Range on HMM: 117-258/263.0
PAFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHggEFTYKQI-PISDHWSQNLSQFFPEAISFIDEARsKKCGVLVHCLAGISRSVT
 . | .|.. |.||. . ..|  .| . |. .||    ..   | .   | |  |  | |    ..||.| |  .||.| | || |||||| ||.||| |
ssvPdeiidklflGgldsannksilkdlgvthillavadfePlfPk..lfkylsiddiedvdeadisqhfeetnafieeGr.kkGGvlvhcraGvsrsst

VTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
....|||.| .| ...|.|.|..|...| ||  |. ||. .|. |
lvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl

0037934 (Phosphotyrosine protein) phosphatases II 242-384 2.2e-27 91.6 In-house 36-240 (243) alignment
Range on Protein: 242-384
Range on HMM: 36-240/243.0
PAFPVQILPYLYLGCA--------KDSTNLDVLGKYGIKYILNVTPNL------------------------------------------PN-AFEHGGE
.|  ....|.|.....        .. .... | ..||..|...|.                                            ..   ..   
nanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlv

FTYKQIPISDH---W-SQNLSQFFPEAISFIDE-----ARSKKCGVLVHCLAGISRSVTVTVAYLMQKM-NLSLNDAYDFVKRKKSN-ISPNFNFMGQLL
. | ..|. ||      ..| .|. |...||.|     |....  ||||| ||..|. |. .|||| .. ...| .|.......... . ...... .| 
ihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfly

DFERT
.... 
ealle

0048179 (Phosphotyrosine protein) phosphatases II 243-384 1.6e-38 127.0 In-house 2-143 (144) alignment
Range on Protein: 243-384
Range on HMM: 2-143/144.0
AFPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVT
 .|..|||.||||.  .. .|. | |.||....|.|.. ...|.    ..| ..|. ||   .|.....|.. ||.||..... ||||| ||..|. |. 
snpseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

VAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERT
.|||| |..|||..|...|... ... ||.... .||..|. 
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl

0045098 (Phosphotyrosine protein) phosphatases II 243-385 7.3e-29 96.4 In-house 20-271 (278) alignment
Range on Protein: 243-385
Range on HMM: 20-271/278.0
AFPVQILPYLYLGCAK-----------------------------------------DSTNLDVLGKYGIKYILNVTPNLPNA-----------------
 .| .|.|.||||...                                          . ... | ..||..|...|. ....                 
gipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltyg

----------------------------FEHGGEFTYKQI---PISDHWSQNLS--QFFPEAISFIDEARS--------------KKCGVLVHCLAGISR
                            .|.. ... ...   |. || . .|.  ..| |.. ||.||..              ... ||||| ||..|
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

SVTVTVAYLMQKM---NLSLNDAYDFVKRKKSN-ISPNFNFMGQLLDFERTL
. |. .|||| ..   ...| .|........ . . .|.... .| .|.. |
tGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel

subfamily_STYXL1_pd Subfamily STYXL1 243-385 1e-26 87.0 In-house 9-153 (157) alignment
Range on Protein: 243-385
Range on HMM: 9-153/157.0
AFPVQILP-YLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGE-FTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVT
 .||..||  ||||  |...|  .     .|  .||. .  . ..   .     .|...|.   .| ... ||..||.. . ..  |||    |||||..
tyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaa

VTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
| .|||| . ...|..||...|. |.|. || .|. || ..|..|
viiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql

subfamily_DSP8_pd Subfamily DSP8 244-386 1.3e-47 155.3 In-house 14-155 (159) alignment
Range on Protein: 244-386
Range on HMM: 14-155/159.0
FPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAfEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTV
 | .||..||||. ||. . ..| |.|| |.||.  . |.  |   |  . ..|. |. . .|...|.....||| |.|... ||||.||||||| || .
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkl.eelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvai

AYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLG
||.|.....||..|| ||| |.  ||||.||.||||..|..| 
ayimktlemsldeayrfvkekrptispnlnflgqLleyekelk

0043147 (Phosphotyrosine protein) phosphatases II 244-385 2.5e-36 120.4 In-house 18-160 (172) alignment
Range on Protein: 244-385
Range on HMM: 18-160/172.0
FPVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPN-LPNAFEHGGEFTYKQIPISDHWSQnLSQFFPEAISFIDE--ARSKKCGVLVHCLAGISRSVT
 | ..........  .. ... | ..||..|.|.|.  ..  ...   ..|  .|. ||. . |.....|...||||  |.|... ||||| ||..|..|
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

VTVAYLMQkMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
. .||||. ..||| .|...|..|......|.... .|..||..|
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll

0046846 (Phosphotyrosine protein) phosphatases II 244-384 3.8e-30 100.3 In-house 11-171 (176) alignment
Range on Protein: 244-384
Range on HMM: 11-171/176.0
FPVQILPYLYLGCAK----------DSTNLDVLGKYGIKYILNVTPNL----------PNAfEHGGEFTYKQIPISDHWSQNLsQFFPEAISFIDEARSK
....|...|.||..             ..|. | ..||....|.|             ..  ... ...|...|. ||.  .| . ..|.. ||.||...
dldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgiqylhlpwpDhgvpdl.elllellefirealke

KCGVLVHCLAGISRSVTVTVAYLMQK-MNLSLNDAYDFVKRKKS-NISPNFNFMGQLLDFERT
.  ||||| |||.|. |. .|||... ..||...|...|..... .. ...... .| .||. 
ggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 244-383 1.7e-28 93.0 In-house 6-145 (148) alignment
Range on Protein: 244-383
Range on HMM: 6-145/148.0
FPVQILP-YLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHGGeFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVT
|| .| . .|.||  |  ..|..| . |.  | | | . .||... |   | .....|.  ..||..|...|.|...|...   ||||.  |.|||  ..
fpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrg.ieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssala

VAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFER
...|..  . ||..|...|| |.  . ||  |. || ..|.
llwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq

subfamily_DSP10_pd Subfamily DSP10 245-385 2.2e-61 200.4 In-house 14-153 (159) alignment
Range on Protein: 245-385
Range on HMM: 14-153/159.0
PVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHgGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVA
 .|.||.|.|| .||...||.| ...|...||||...|| ||.  ...||.||.||  .|||.| | ||. ||.|||.|   ||||| ||||||.||..|
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
|||...||||||||.||| |.. ||||.|||||||.||..|
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekel

PTPc_motif_SM00404 245-383 1e-47 156.5 In-house 2-139 (140) alignment
Range on Protein: 245-383
Range on HMM: 2-139/140.0
PVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAfEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVA
| .|||.|||| .....|...| |.||....||| . ..  ..  .|...|||..|. ...||........||..|..|.. ||||| ||.|||.|...|
psrilphlylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFER
|||....|||..||.|||.....||||.||. ||...|.
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyek

0049260 (Phosphotyrosine protein) phosphatases II 245-385 1.2e-32 108.1 In-house 8-149 (152) alignment
Range on Protein: 245-385
Range on HMM: 8-149/152.0
PVQILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFE-HGGEFTYKQIPISDHWSQNLSQFFPEAISFIDE-ARSKKCGVLVHCLAGISRSVTVT
| ........|.   . ... | ..||..|...|  |..... .   ..|...|. ||. ..|||...... ||.. |..|.. ||||| ||..|. |. 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

VAYLMQkMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
.||||  ...|| .|...|..|.... ||.... .|..||..|
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll

subfamily_MKPLT_pd Subfamily MKPLT 245-383 3.1e-28 92.3 In-house 21-158 (164) alignment
Range on Protein: 245-383
Range on HMM: 21-158/164.0
PVQILP-YLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHggEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTV
|  .|.  |||| ||..||  || .  |..|.||. .  .|| .   . | |. ..|   ..||.|.  |  |. .|      |||||  | ||| .|||
psvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtv

AYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFER
|.|..     |..||...| ..| ..||  |. ||  ||.
afLikskgwtlkeayeylkerrsivapnrGflkqlakfee

subfamily_MKPLV_pd Subfamily MKPLV 245-383 3.1e-28 92.3 In-house 21-158 (164) alignment
Range on Protein: 245-383
Range on HMM: 21-158/164.0
PVQILP-YLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHggEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTV
|  .|.  |||| ||..||  || .  |..|.||. .  .|| .   . | |. ..|   ..||.|.  |  |. .|      |||||  | ||| .|||
psvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpk..sveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtv

AYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFER
|.|..     |..||...| ..| ..||  |. ||  ||.
afLikskgwtlkeayeylkerrsivapnrGflkqlakfee

subfamily_DSP14_pd Subfamily DSP14 246-385 1.8e-34 113.0 In-house 8-144 (157) alignment
Range on Protein: 246-385
Range on HMM: 8-144/157.0
VQILPYLYLGcAKDSTNLDVLGKYGIKYILNVTPNLPNafEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAY
.|| |.|.|. .  ... ..| |..|  |.|||..|||  ..  .. . ..|..|. ...|...| |..  |.|.. |.  .|||| ||.||| ....||
sqitpsLfls.gvaalskellkkkkitliinvtvelpn..tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

LMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
||.  .|||..||  || ... |.||  |  || |.|. |
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkkl

0036282 (Phosphotyrosine protein) phosphatases II 246-385 3.3e-30 100.5 In-house 13-169 (174) alignment
Range on Protein: 246-385
Range on HMM: 13-169/174.0
VQILPYLYLGCAKDStNLDVLGKYGIKYILNVTPNLPN-------------AFEHGGEFTYKQIPISDHWSQNLSQfFPEAISFIDEARSK--KCGVLVH
. |.|.|..|..  . ... | ..||........  ..              ...   ..|...|. ||   .||. . |...|..||.|.  .. ||||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CLAGISRSVTVTVAYLMQKMNL-SLNDAYDFVKRKK---SNISPNFNFMGQLLDFERTL
| ||..|. |. .|||| .. | || ||.|.|....   ... ...... .| .||. |
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll

subfamily_DSP19_pd Subfamily DSP19 247-384 5.6e-39 127.9 In-house 14-149 (152) alignment
Range on Protein: 247-384
Range on HMM: 14-149/152.0
QILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEHggEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYL
.. |.||||     .. . | . .| .||||. ..||.| .  .|||..|.| |.  ..|.....||. ||.|||||.  ||||| ||.|||..| .|||
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpk..dftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviayl

MQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERT
|.| .|||..|.. |. .. .|.||  |. || ..| .
mkkeelsleealelvrearpcikPneGFikqLkeyeae

subfamily_DSP12_pd Subfamily DSP12 247-385 1.5e-38 126.6 In-house 4-143 (155) alignment
Range on Protein: 247-385
Range on HMM: 4-143/155.0
QILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPN-LPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAY
.||| |||| ... .. . | ...|. .| |. . ||.  .. |. ..|.|.| |. .... ....||..||.||....  ||||| ||.|||||. .||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
||.| .|||..|...||.||..|.|| .|. ||  ||.  
lmkkeklslekAlklvkekkpeiepNegFleQLklfekmg

subfamily_DSP15_pd Subfamily DSP15 247-384 2.8e-37 122.1 In-house 4-138 (151) alignment
Range on Protein: 247-384
Range on HMM: 4-138/151.0
QILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPnlpNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYL
..|| ||||  .|| . . |..  |  ||.|     || ..  ...|| |..||  |..||.|| |...|| ..|.|. .||||||||.|||||..||||
kvlpglylgnfrdskdeelLkeknithilsvhd...nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERT
|  ..|. .|| ...| ..|   ||| |  || ..|.|
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyekt

0051082 (Phosphotyrosine protein) phosphatases II 247-380 4.1e-25 83.6 In-house 10-148 (151) alignment
Range on Protein: 247-380
Range on HMM: 10-148/151.0
QILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPNL-----PNAFEHGGeFTYKQIPISDHWSQNLSQFFPEAISFIDEARSK-KCGVLVHCLAGISRSVT
.. ..||.. .  . .|. | ..|||.|.|...       |. ..  | .....||| |.. ..|...|.....|......| .  ||||| ||..|. |
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelg.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

VTVAYLMQkMNLSLNDAYDFVKRKKS-NISPNFNFMGQLLD
. ..|||  ...||..|......|    . ||  |. ||..
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa

0042113 (Phosphotyrosine protein) phosphatases II 247-383 3.3e-24 81.1 In-house 49-240 (245) alignment
Range on Protein: 247-383
Range on HMM: 49-240/245.0
QILPYLYLGCAKDSTNLD----VLGKYGIKYILNVTPNLP--------------------------------------------NAFEHGGEFTYKQIPI
.| | .... .  . ...     | ..||..|...|.  .                                              .|.   ..| ..|.
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

SDHWSQNLSQFFPEAISFIDEARS--KKCGVLVHCLAGISRSVTVTVAYLM-----QKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFER
 ||   .|.. . ....|...|..  ..  ||||| ||..|. |. .||||       ...|| .|........... ...... .| ....
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

subfamily_STYX_pd Subfamily STYX 247-383 1.3e-23 76.9 In-house 14-155 (166) alignment
Range on Protein: 247-383
Range on HMM: 14-155/166.0
QILPYLYLGC--AKDSTNLDVLGKYGIKYILNVTPNLPNAF---EHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTV
.||| |.||   |   . |.|| | || .|. .  |.  ..   .   .| |  . ..|   .|. ...|.  .|||.. .|   ||||  |||||| ..
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

TVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFER
 .||.|. . |   .|. .|....  |.||  |. || ..| 
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyea

subfamily_DSP3_pd Subfamily DSP3 248-385 9.2e-29 94.2 In-house 14-157 (162) alignment
Range on Protein: 248-385
Range on HMM: 14-157/162.0
ILPYLYLGCAKDSTNLDVLGKYGIKYILNVTPN------LPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSK-KCGVLVHCLAGISRSVT
. | ||.| .. ... . | | || ..|| .          . | .. |..|  ....|  . .||..| .| .||||| |. .  ||||| .|.||| |
vypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsat

VTVAYLMQKMNLSLNDAYDFVKrKKSNISPNFNFMGQLLDFERTL
. .|||| . ...|..|   |. || .| ||  |. || .... |
lvlayLmirrkmtlveairtvr.kkReilPneGFlkqLaeldeel

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 251-384 1.6e-24 80.0 In-house 9-151 (154) alignment
Range on Protein: 251-384
Range on HMM: 9-151/154.0
YLYLGCAKDSTNLDVLGKYGIKYILNVTPNLPNAFEH-------GGEFTYKQIPISDHWSQNLSQFFPEAISFIDEAR--SKKCGVLVHCLAGISRSVTV
.||..  . . |   | .. || ||||    .|.| .       |  . | .. . |.  ... . .  |  |||.|    .. .||||. .|.||| ..
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

TVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERT
 ..|||.|...||  |. ..|  .  |.||  |. ||  ||. 
lisylmdklkislslalellkdsryiikPnqGflkqleifeke

DSPc Dual specificity phosphatase, catalytic domain 252-383 1.5e-44 146.1 Pfam-A 1-132 (133) alignment
Range on Protein: 252-383
Range on HMM: 1-132/133.0
LYLGCAKDSTnLDVLGKYGIKYILNVTPNLPN-AFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKM
|||| ..... |..| |.||....||| . ||  . . .|..| .||. |......|....||..||..|..|.. ||||| |||||| |...||||...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NLSLNDAYDFVKRKKSNISPNFNFMGQLLDFER
|||||.||.|||...|.||||..|..|||..||
nlslneAyefvkerrskispnagflrqLleyer

DSPc Dual specificity phosphatase, catalytic domain 252-383 1.5e-44 146.1 In-house 1-132 (133) alignment
Range on Protein: 252-383
Range on HMM: 1-132/133.0
LYLGCAKDSTnLDVLGKYGIKYILNVTPNLPN-AFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKM
|||| ..... |..| |.||....||| . ||  . . .|..| .||. |......|....||..||..|..|.. ||||| |||||| |...||||...
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

NLSLNDAYDFVKRKKSNISPNFNFMGQLLDFER
|||||.||.|||...|.||||..|..|||..||
nlslneAyefvkerrskispnagflrqLleyer

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 252-385 2.1e-26 85.7 In-house 6-141 (145) alignment
Range on Protein: 252-385
Range on HMM: 6-141/145.0
LYLGCAKDSTNLDVLGKYGIKYILNVT--PNLPNAFEHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQK
|| | |  . .. .| . ||  |.|..    .     .. ...   |  .|  | .||| | |   |||  . .  ||.|||.||.||||||.||.||. 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

MNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
 |..| .|   |. ..    || .|. .||..|. |
cnmtlseaarqvrsnrllaypnvtflknllnlekql

0051429 (Phosphotyrosine protein) phosphatases II 253-383 3.6e-18 61.7 In-house 25-222 (272) alignment
Range on Protein: 253-383
Range on HMM: 25-222/272.0
YLGCAK---DSTNLDVLGKYGIKYILNVTPNL----PNAFEHGGEFTYKQIPISDHWSQNLSQFF-----------------------------------
|.. .    .  ... | ..|||.|.....       . . .   ..| ..|| |.  .  ....                                   
yrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmh

-------------PEAISFIDEARSkKCGVLVHCLAGISRSVTVTVAYLMQkMNLS--------------LNDAYDFVKRKKSNISPNFNFMGQLLDFER
              . ...... .. .  ||||| ||..|. || ...|.  ...|              | .|.. ....  .. ..  .. .|.....
lhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeall





subfamily_DSP23_pd Subfamily DSP23 262-365 7e-12 40.2 In-house 23-125 (148) alignment
Range on Protein: 262-365
Range on HMM: 23-125/148.0
NLDVLGKYGIKYILNVTPNLPNAFEHGGEFTYKQIPISDHWSQNLSQFfPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFV
..  |   |..|.. .| . .   |   . |.... | |.    | |   | .  ..|| .|.  | |||| |  |. |.   ||... .|.  .|   |
qyrylldlgvrylvslteegrphveatpnltlvrlriddyhppaleqv.vefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaev

KRKK
.|..
rrlr

0040439 (Phosphotyrosine protein) phosphatases II 263-385 1e-26 89.5 In-house 71-245 (249) alignment
Range on Protein: 263-385
Range on HMM: 71-245/249.0
LDVLGKYGIKYILNVTPNLPNAF-----------------------------------------EHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEAR
.. | ..||..|...|.  .. .                                         ..| ..|...|.. |   ......|.....||...|
wrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavr

S------KKCGVLVHCLAGISRSVTVTVAYLM-----QKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
.      |.. ||||| ||..|. |. .||||      . ...| .|........... .|.... .|..... |
kaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

0045450 (Phosphotyrosine protein) phosphatases II 264-385 7.9e-26 86.9 In-house 125-303 (307) alignment
Range on Protein: 264-385
Range on HMM: 125-303/307.0
DVLGKYGIKYILNVTPNLPNAFE--------------------------HGGEFTYKQIPISDH-----------------WSQNLSQFFPEAISFIDEA
  | ..|...|...|.  ....|                          | ...|. .....|.                   ......| |...||.|.
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RS------KKCGVLVHCLAGISRSVTVTVAYLMQKMN--------LSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
|.      |.. ||||| ||..|. |. .|||| ..         ..| .|........... .|.... .| .... |
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel

0040438 (Phosphotyrosine protein) phosphatases II 266-386 1.2e-22 76.1 In-house 106-276 (317) alignment
Range on Protein: 266-386
Range on HMM: 106-276/317.0
LGKYGIKYILNVTPNLPNA-------------------------FEHGGEFTYKQIPISDH----------------WSQNLSQFFPEAISFIDEARSK-
. ..|...|...|.  ..                          .|. ...|. .....|.                  ... . . . ..|....|.. 
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

---KCGVLVHCLAGISRSVTVTVAYLM-----QKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTLG
   .. ||||| ||..|. |. .||||     ....... .|........... ...... .| |... . 
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

0039614 (Phosphotyrosine protein) phosphatases II 266-384 4.6e-22 74.3 In-house 121-287 (297) alignment
Range on Protein: 266-384
Range on HMM: 121-287/297.0
LGKYGIKYILNVTPNLPNA-----------------------FEHGGEFT-----------------YKQIPISDHWSQNLSQFFPEAISFIDEARS---
. ..|...|...|.  ..                        .|| . .|                 .  ... ||   .... . |.. ...||..   
vweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelp

KKCGVLVHCLAGISRSVTVTVAYLM-----QKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERT
|.. ||||| ||..|. |. .||||      . .... .|........... ...... .| |... 
kggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle

0036941 (Phosphotyrosine protein) phosphatases II 268-385 2.3e-17 58.7 In-house 100-276 (297) alignment
Range on Protein: 268-385
Range on HMM: 100-276/297.0
KYGIKYILNVTPNLPNAF---------------------------------------------EHGGEFTYKQIPISDHWSQNLSQFFPEAISFIDEARS
..... |...|.  .. .                                             . | ..| ... . .    .. . . . ..||...|.
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

------KKCGVLVHCLAGISRSVTVTVAYLM--------QKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
      ..  ||||| ||..|| |. .|.||           .... .|. ...... .. ...... .| ...  |
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel

0043336 (Phosphotyrosine protein) phosphatases II 269-383 2e-16 55.7 In-house 156-274 (278) alignment
Range on Protein: 269-383
Range on HMM: 156-274/278.0
YGIKYILNVTPNLPNAFEHGGEFTYKQIPisDHWSQ-NLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLM-----QKMNLSLNDAYDFVK
. . . |.||..  .   ..  . |. .|  ||    .||...     ...  ....  ||||| ||..|. |. ..||.        ...| .|.....
dytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelr

RKKSNISPNFNFMGQLLDFER
... .. ...... .| ....
eqRpgavqtpsqyrflyeall

0051299 (Phosphotyrosine protein) phosphatases II 269-373 5e-12 41.3 In-house 161-273 (288) alignment
Range on Protein: 269-373
Range on HMM: 161-273/288.0
YGIKYILNVTPN----LPNAFEHGGEFTYKQIPisDHWSQN-LSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLM-----QKMNLSLNDAY
. ... | ||..     ..   .   | |...|  ||   . .....     ...  .|... |.||| ||..|. |. ...|.     ..  ... .|.
dytvrtlevtnldlldgdgesrtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleav

DFVKRKKSNISPNFN
 ...... .. ....
krlreqRpgmvqtpe

0046845 (Phosphotyrosine protein) phosphatases II 270-371 1.2e-10 36.7 In-house 148-259 (284) alignment
Range on Protein: 270-371
Range on HMM: 148-259/284.0
GIKYILNVTPNL-PNAFEHGGEFTYKQIPisDHWSQNLSQFFPEAISFIDEARSK---KCGVLVHCLAGISRSVTVTVAYLMQKM--------NLSLNDA
 ... | .|..  ..   .   | |...|  ||     .. . | . ...|....   .. ..||| ||..|. |. ...|. ..        .... .|
ytvrtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvlea

YDFVKRKKSNISPN
. ...... .   .
vkrlreqRpgmvqt

0047943 (Phosphotyrosine protein) phosphatases II 273-379 1.9e-12 42.7 In-house 153-265 (273) alignment
Range on Protein: 273-379
Range on HMM: 153-265/273.0
YILNVTPNLPNAFEHGGEFTYKQIPisDHWSQNLSQFFPEAISFIDEARS---KKCGVLVHCLAGISRSVTVTVAYLM-----QKMNLSLNDAYDFVKRK
. | .|..  .   .   | |. .|  ||      . . | | ....|..   ..  |.||| ||..|. |. ...|.      . .... .|. .....
rtleltnlgtgesrtvthfhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsq

KSNISPNFNFMGQLL
. .. ...... .| 
Rpgmvqtpeqyrfly

0049772 (Phosphotyrosine protein) phosphatases II 282-385 6.2e-31 103.7 In-house 173-273 (314) alignment
Range on Protein: 282-385
Range on HMM: 173-273/314.0
PNAFEHGGeFTYKQIPISDhWSQNLSQFFPEAISFIDEArSKKCGVLVHCLAGISRSVT-VTVAYLMQKMNLSLNDAYDFVKRKKSnISPNFNFMGQLLD
|. ||. | ..|..||..| .|..|...|.|.. ||.|| .|.  ||||| ||..|. | |..|||| ....||..|...|..| . |.||..|. ||..
pelferlg.ikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleq

FERTL
.|  |
yefil

0038934 (Phosphotyrosine protein) phosphatases II 285-384 1.4e-20 69.2 In-house 74-175 (194) alignment
Range on Protein: 285-384
Range on HMM: 74-175/194.0
FEHGGEFTYKQIPISDHWS----QNLSQFFPEAISFIDEarSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLD
  ..  ..| ..|. |...    ..| .|.  .  |..|  .... |.||| ||..|. |. .|||......|...|......|. .. || ... .|| 
efekagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallk

FERT
. ..
ryke

subfamily_PTPMT1_pd Subfamily PTPMT1 291-381 3.3e-16 54.2 In-house 74-164 (171) alignment
Range on Protein: 291-381
Range on HMM: 74-164/171.0
FTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDF
 .. |... |.  .   .   ... ||.. .||.  | ||| || .|| |.  .|||.| .||...| ...|.|.. |  . . . .|  .
veqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqey

subfamily_Laforin_pd Subfamily Laforin 291-365 7.7e-07 22.2 In-house 77-151 (183) alignment
Range on Protein: 291-365
Range on HMM: 77-151/183.0
FTYKQIPISDHWSQNLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKK
..|  .|. |  ...  . .|.|. ..     |   | ||| ||. || .. . .|.  .. ||.    |.  |.
layiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakr

0050432 (Phosphotyrosine protein) phosphatases II 292-372 5.7e-10 34.5 In-house 203-285 (308) alignment
Range on Protein: 292-372
Range on HMM: 203-285/308.0
TYKQIPisDHWSQNLSQFFPEAISFIDEARsKKCGVLVHCLAGISRSVTVTVAYLM-----QKMNLSLNDAYDFVKRKKSNISPNF
 |.  |  ||   .  . . . . .... . ... ..||| ||..|. |. ...|.     .. .... .|. ...... .  ...
hytnWp..dhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp

subfamily_PTEN_pd Subfamily PTEN 295-366 2.5e-06 22.6 In-house 84-157 (184) alignment
Range on Protein: 295-366
Range on HMM: 84-157/184.0
QIPISDHWSQNLS---QFFPEAISFIDEarSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLN-DAYDFVKRKKS
..|..|| . .|.   ..  .. ....|  .||  | ||| ||  |. ...||||.... |. . .| .. .....
vypfdDhnppplelleeivediekwlee..dkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt

subfamily_MSG5_pd Subfamily MSG5 301-385 3.6e-19 62.5 In-house 77-160 (165) alignment
Range on Protein: 301-385
Range on HMM: 77-160/165.0
HWSQnLSQFFPEAISFIDEARSKKCGVLVHCLAGISRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNFMGQLLDFERTL
| |. . . ...  . |  |.||.  .||||  |.||| .. |||.|.  ||||.|||| .| .  .|||.. .. ||...| .|
hdsk.ivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval

0048567 (Phosphotyrosine protein) phosphatases II 306-374 1.3e-07 26.2 In-house 56-127 (157) alignment
Range on Protein: 306-374
Range on HMM: 56-127/157.0
LSQFFPEAISFIDEARSKKCGVLVHCLAGI---SRSVTVTVAYLMQKMNLSLNDAYDFVKRKKSNISPNFNF
| .|.  . .|..  . ... . ||| ||    .|..|.  .||. ..... ..|.....    .. |    
lyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrda

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 310-354 2.8e-06 21.6 In-house 195-240 (307) alignment
Range on Protein: 310-354
Range on HMM: 195-240/307.0
FPEAISFIDEARSKKCGVLVHCLAGISRSVT-VTVAYLMQKMNLSL
   || ...  | ..  |.||| ||. || | |.......||    
nltainlleavrydtnpvvvhcsaGvGrsGtivaislvqdkmiaGi

PTPc_DSPc_SM00012 311-354 1.2e-06 24.0 In-house 20-69 (105) alignment
Range on Protein: 311-354
Range on HMM: 20-69/105.0
PEAISFIDEARSKKC------GVLVHCLAGISRSVTVTVAYLMQKMNLSL
 . ...... ...|        |.||| ||..|. |....... ... . 
dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleke

Y_phosphatase Protein-tyrosine phosphatase 311-352 7.1e-06 21.0 Pfam-A 153-199 (235) alignment
Range on Protein: 311-352
Range on HMM: 153-199/235.0
PEAISFIDEARSKK----CGVLVHCLAGISRSVT-VTVAYLMQKMNL
 . ...|.. ...|      |.||| ||..|. | |.. .|..... 
kslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea

Y_phosphatase Protein-tyrosine phosphatase 311-352 7.1e-06 21.0 In-house 153-199 (235) alignment
Range on Protein: 311-352
Range on HMM: 153-199/235.0
PEAISFIDEARSKK----CGVLVHCLAGISRSVT-VTVAYLMQKMNL
 . ...|.. ...|      |.||| ||..|. | |.. .|..... 
kslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqlea