Gene DUSP9 in Homo sapiens

Synonym: MKP-4, MKP4, DUSP9

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP6
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP031_AA protein Get Run
HsapP031_AA_201-347 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 11-133 3.5e-09 29.2 Pfam-A 5-113 (113) alignment 
Range on Protein: 11-133
Range on HMM: 5-113/113.0
LRRELspPRPRLLLLDCRSRELYESARIGGALSVALPALLLRRLRRGSLSVRALLPGPPLQPPPPAPVLLYDqgggrrrrgeaeaeAEEWEAESVLGTLL
| . |    ....|||.|| | |.  .| ||..|.|. |  ||  .        |.    . ..  .|..|.              .  . .. .  .||
lkell..ekekvvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdktvvvyc..............rsgnrsggaaalll

QK-LREEGY-LAYYLQGGFSRFQAE
.. |.| ||   |.| |||. ..||
alilkelgyknvyvLdGGfeawkae
subfamily_LRR-DSP_pd Subfamily LRR-DSP 199-344 7.2e-32 104.5 In-house 115-258 (263) alignment 
Range on Protein: 199-344
Range on HMM: 115-258/263.0
LRASFPVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKNgdFHYKQI-PISDHWSQNLSRFFPEAIEFIDEAlSQNCGVLVHCLAGVSRS
| .| | .|...|.||.   . |   | .||. .||    ..  .| |   | |  |  | |    ..|..| |   ||.|   .. |||||| ||||||
lvssvPdeiidklflGgldsannksilkdlgvthillavadfePlfPkl..fkylsiddiedvdeadisqhfeetnafieeG.rkkGGvlvhcraGvsrs

VTVTVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSL
 |....|||.| .| ...|.|||..|...| ||  |. ||. .|. |
stlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekkl
subfamily_DSP6_pd Subfamily DSP6 200-347 2.3e-82 268.2 In-house 10-157 (158) alignment 
Range on Protein: 200-347
Range on HMM: 10-157/158.0
RASFPVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVT
.|.|||.|||.||||||.|..|||.|.||.|.|.||||.||||.||..|...|.||||.||.||||..|||||||||||| |....||||||||.|||||
eaefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

VTVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRLE
||.||||.||.|||||||||||..|||||||||||||||||||||||.
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrls
0045098 (Phosphotyrosine protein) phosphatases II 200-345 8.6e-31 102.8 In-house 18-272 (278) alignment 
Range on Protein: 200-345
Range on HMM: 18-272/278.0
RASFPVQILPNLYLGSAR-----------------------------------------DSANLESLAKLGIRYILNVTPN-------------------
. ..| .|.|.||||..                                           ..... | .|||..|...|.                    
llgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslt

--------------------------L---PNFFEKNGDFHYKQIPISDHWSQNLS--RFFPEAIEFIDEALS--------------QNCGVLVHCLAGV
                          |   .. .|..| .|.. .|. || . .|.  ..| |..|||.|||.              ... ||||| |||
ygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGv

SRSVTVTVAYLMQKL---HLSLNDAYDLVKRKKSN-ISPNFNFMGQLLDFERSLR
.|. |. .|||| .|   ...| .|.. ..... . . .|.... .| .|.. |.
gRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_DSP10_pd Subfamily DSP10 201-346 2e-59 194.0 In-house 11-155 (159) alignment 
Range on Protein: 201-346
Range on HMM: 11-155/159.0
ASFPVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKnGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTV
.   .|.|| |.|||..|.|.|..| .|.| ..||||...||.||.  ...||.||.||  .|||.. | ||.|||.|| ...  ||||| ||.|||.||
tapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee.ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatv

TVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRL
..||||..|.|||||||..|| |.. ||||.|||||||.||..|. 
viaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnk
0048179 (Phosphotyrosine protein) phosphatases II 202-343 4.3e-41 135.3 In-house 2-143 (144) alignment 
Range on Protein: 202-343
Range on HMM: 2-143/144.0
SFPVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVT
|.|..|||.|||||  .. .|| |.||||....|.|.. .. |...  ..| ..|. ||   .|. ...|..|||.|||.... ||||| |||.|. |. 
snpseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

VAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERS
.|||| ||.|||..|..||... ... ||.... .||..|. 
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
subfamily_MKPLT_pd Subfamily MKPLT 202-342 5.1e-28 91.7 In-house 19-158 (164) alignment 
Range on Protein: 202-342
Range on HMM: 19-158/164.0
SFPVQILP-NLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKNgdFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTV
..|  .|. .|||| | .. | . | .| | .|.||. .  . | |   . | |. ..|   ..|| |.  | .|. .|.     |||||  |.||| .|
iypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpks..veYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssv

TVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFER
|||.|..     |..||. .| ..| ..||  |. ||  ||.
tvafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 202-342 5.1e-28 91.7 In-house 19-158 (164) alignment 
Range on Protein: 202-342
Range on HMM: 19-158/164.0
SFPVQILP-NLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKNgdFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTV
..|  .|. .|||| | .. | . | .| | .|.||. .  . | |   . | |. ..|   ..|| |.  | .|. .|.     |||||  |.||| .|
iypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpks..veYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssv

TVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFER
|||.|..     |..||. .| ..| ..||  |. ||  ||.
tvafLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_STYXL1_pd Subfamily STYXL1 202-344 2.9e-25 82.3 In-house 9-153 (157) alignment 
Range on Protein: 202-344
Range on HMM: 9-153/157.0
SFPVQILPN-LYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKNGD-FHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVT
..||..||. ||||  ... | .    | ..  .||. .  ....   |  .  .|...|.   .|  .. ||..||..   ..  |||    |.|||..
tyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaa

VTVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSL
| .|||| . ...|..||. .|. |.|. || .|. || ..|..|
viiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
subfamily_PTEN_pd Subfamily PTEN 202-322 1.4e-07 26.7 In-house 33-154 (184) alignment 
Range on Protein: 202-322
Range on HMM: 33-154/184.0
SFPVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNLpNFFEKNGDFHYKQIPISDHWSQNLSrFFPEAIEFIDEALSQN--CGVLVHCLAGVSRSVT
..|.. | .||  | .|  ..    . .   |.|.. .  .. .|. | . ...|..|| . .|. .. |..| |.. |...    | ||| ||  |. .
gyPaeklealyRnsledvvkflekkhkdhykiynlrser.kydskkfdgrvavypfdDhnppple.lleeivediekwleedkknvvvvHCkaGkGRtGv

VTVAYLMQKLHLSLN-DAYDLVKR
..||||...|.|. . .| .| ..
livayllkslllekaeealelfae
subfamily_DSP8_pd Subfamily DSP8 203-347 1.5e-46 151.9 In-house 14-157 (159) alignment 
Range on Protein: 203-347
Range on HMM: 14-157/159.0
FPVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFfEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTV
 | .||.|||||| .|. . | | |||| |.||.  . |.  |.  . .. ..|. |. . .|. .|....|||| | |.|. ||||.||| ||| || .
gptrilknlylGsqkdvlseellsklgisyvlnasnscpkl.eelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvai

AYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRLE
||.|..|..||..||  || |.  ||||.||.||||..|..|.|.
ayimktlemsldeayrfvkekrptispnlnflgqLleyekelkll
0044763 (Phosphotyrosine protein) phosphatases II 203-346 2.2e-44 146.5 In-house 22-172 (178) alignment 
Range on Protein: 203-346
Range on HMM: 22-172/178.0
FPVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKNGD-------FHYKQIPISDHWSQNLSRFFPEAIEFIDEAL-SQNCGVLVHCLAGV
 ...|||.|||||. ....|| | .|||..|.|.|..|...|.|.         ..|..|||.||  ..|...|.|..|||.||| .... ||||| |||
naseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGv

SRSVTVTVAYLMQKLHLSLNDAYDLVKRKKSnISPNFNFMGQLLDFERSLRL
.|| |. .|||| ||.|||..|..||..... |.||.... ||..||. |. 
gRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
0048076 (Phosphotyrosine protein) phosphatases II 203-344 8.7e-40 131.0 In-house 3-142 (145) alignment 
Range on Protein: 203-344
Range on HMM: 3-142/145.0
FPVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFekNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTV
.| .|||.|||||  .  .|| |..|||...||.|..|....  . ...| ..|. ||  ..|.....|..|||.|||.... ||||| |||.|. |. .
wpseilpglylgslptaldlellkdlgittvlnltselelle..rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlva

AYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSL
|||| .|..|| .|..||... ... ||.... .|..||. |
aylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0041856 (Phosphotyrosine protein) phosphatases II 203-345 5.1e-36 119.3 In-house 18-173 (182) alignment 
Range on Protein: 203-345
Range on HMM: 18-173/182.0
FPVQILPNLYLGSARD--------------SANLESLAKLGIRYILNVTPNL--PNFFEKNGdFHYKQIPISDHWSQNlsrfFPEAIEFIDEALSQNCGV
.. .|..|||||| ..               ..|. | .|||..|.|.|. |  |...|..| ..|...|. ||   .    ..|...||.|.|.... |
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlg.iqylylpwpDhgvpd....ldelldfieevleeggpv

LVHCLAGVSRSVTVTVAYLMQKLHLSLNDAYDLVKRKKS--NISPNFNFMGQLLDFERSLR
|||| |||.|. |. .|||| ||..|| .|..||.....   |.||..|. ||. .|. |.
lVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
PTEN_1 203-346 5.6e-35 115.9 In-house 42-193 (196) alignment 
Range on Protein: 203-346
Range on HMM: 42-193/196.0
FpvQILPNLYLGSARDS-ANLESLAKLGIRYILNVTPNLPN-------FFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNC--GVLVHCLA
   .| ..||.||..|  |.|..| . ||. ..|...  ..        ....... |...|| ||. ..||..| .. .||. .||...   ||||| |
q..eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCka

GVSRSVTVTVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRL
|..||.||  ||||.|  |. ..| .||..| ....||  .. .|| ....|. 
GlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 203-342 4.7e-30 98.0 In-house 6-145 (148) alignment 
Range on Protein: 203-342
Range on HMM: 6-145/148.0
FPVQILPN-LYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKNGdFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVT
|| .| .  |.||| .  |.|| |..||.  | | | . .| ... |  .| .....|.  ..|| .|...|.|...| ..   ||||.  |||||  ..
fpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrg.ieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssala

VAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFER
...|..  . ||..|..||| |.  . ||  |. || ..|.
llwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_DSP1_pd Subfamily DSP1 204-348 1.1e-48 159.4 In-house 17-160 (163) alignment 
Range on Protein: 204-348
Range on HMM: 17-160/163.0
PVQ-ILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKngDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTV
||. ||. |||||. ...||| |..|||  ||||. .|.|.||.   |.||.....|. ....|  | |.||||||. ..|  ||.|| ||.||| |. .
PvekildfLylGsetvasnleiLkslgitailnvskeldnvfed..lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcl

AYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRLEE
||||.. ..||..|.|.||...| ||||..|..|||..|..| ||.
aylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklllel
PTPc_motif_SM00404 204-342 1.9e-47 155.7 In-house 2-139 (140) alignment 
Range on Protein: 204-342
Range on HMM: 2-139/140.0
PVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFfEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVA
| .|||.|||||.... |.. |.||||....||| . ..  ..| .|...|||..|. ...||........||..| .... ||||| ||||||.|...|
psrilphlylgskskaqnpallkklgithvinvteevslt.kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFER
|||.. .|||..||..||.....||||.||. ||...|.
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0043147 (Phosphotyrosine protein) phosphatases II 204-347 7.3e-37 122.1 In-house 19-163 (172) alignment 
Range on Protein: 204-347
Range on HMM: 19-163/172.0
PVQILPNLYLGSARDSANLESLAKLGIRYILNVTPN-LPNFFEKNGDFHYKQIPISDHWSQnLSRFFPEAIEFIDE--ALSQNCGVLVHCLAGVSRSVTV
| ..........  .. ... | .|||..|.|.|.  ..  ...  ...|  .|. ||. . |.....|..|||||  |||... ||||| |||.|..|.
pdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

TVAYLMQkLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRLE
 .||||. |.||| .|..||..|......|.... .|..||. |.| 
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllll
subfamily_Slingshot_pd Subfamily Slingshot 204-346 1.6e-36 119.2 In-house 19-159 (169) alignment 
Range on Protein: 204-346
Range on HMM: 19-159/169.0
PVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEknGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVA
. .|   .||||  ...||| | . |..|||||| .. |||.  ..|.|..| . |. ...| ... |. .||..| ...  |||||  ||||| .. .|
askifdhvylGsewnasnleelkengveyilnvtkeidnffp..ekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

YLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRL
| |.. .|||..|.. ||...| | || .|. ||  .|  |. 
yamkeyglsleealeyvkerrsvikPnkgflkqleeyeGilea
0046846 (Phosphotyrosine protein) phosphatases II 204-344 5.5e-33 109.5 In-house 12-172 (176) alignment 
Range on Protein: 204-344
Range on HMM: 12-172/176.0
PVQILPNLYLGSAR----------DSANLESLAKLGIRYILNVT----------PNLPNFfEKNGDFHYKQIPISDHWSQNLsRFFPEAIEFIDEALSQN
...|..||.|||.             ..|| | .|||....|.|          ||...  ... ...|...|. ||.  .| . ..|..|||.|||...
ldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe.leklgiqylhlpwpDhgvpdl.elllellefirealkeg

CGVLVHCLAGVSRSVTVTVAYLMQK-LHLSLNDAYDLVKRKKS-NISPNFNFMGQLLDFERSL
  ||||| ||..|. |. .|||...  .||...|..||..... .. ...... .| .||. |
gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0049260 (Phosphotyrosine protein) phosphatases II 204-344 6.7e-33 108.9 In-house 8-149 (152) alignment 
Range on Protein: 204-344
Range on HMM: 8-149/152.0
PVQILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEK-NGDFHYKQIPISDHWSQNLSRFFPEAIEFIDE-ALSQNCGVLVHCLAGVSRSVTVT
| ........|.   . ... | .|||..|...|  |.. ..| .  ..|...|. ||. ..|| .......||.. ||.... ||||| |||.|. |. 
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

VAYLMQkLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSL
.||||  |..|| .|..||..|.... ||.... .|..||. |
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
subfamily_DSP14_pd Subfamily DSP14 205-347 1.3e-34 113.4 In-house 8-147 (157) alignment 
Range on Protein: 205-347
Range on HMM: 8-147/157.0
VQILPNLYLGsARDSANLESLAKLGIRYILNVTPNLPNffEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAY
.|| |.|.|. .. . . | |.| .|  |.|||..|||  .|  |... ..|..|. ...|...| |... |.|.  ..  .|||| |||||| ....||
sqitpsLfls.gvaalskellkkkkitliinvtvelpn..tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

LMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRLE
||.  .|||..|| ||| ... |.||  |  || |.|. |. .
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgk
0037934 (Phosphotyrosine protein) phosphatases II 205-343 6.1e-29 96.7 In-house 40-240 (243) alignment 
Range on Protein: 205-343
Range on HMM: 40-240/243.0
VQILPNLYLGSA--------RDSANLESLAKLGIRYILNVTPNL------------------------------------------PN-FFEKNGDFHYK
....|.|.....        .. .... | .|||..|...|.                                            ..   ..  ..|| 
iyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyh

QIPISDH---W-SQNLSRFFPEAIEFIDE-----ALSQNCGVLVHCLAGVSRSVTVTVAYLMQKL-HLSLNDAYDLVKRKKSN-ISPNFNFMGQLLDFER
..|. ||      ..| .|. |..|||.|     ||...  ||||| |||.|. |. .|||| .| ...| .|..|....... . ...... .| ....
ylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall

S
 
e
subfamily_DSP19_pd Subfamily DSP19 206-344 3.8e-41 135.0 In-house 14-150 (152) alignment 
Range on Protein: 206-344
Range on HMM: 14-150/152.0
QILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKngDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYL
.. |.|||||    |. |.| . .| .||||. ..||.| |  ||.|..|.| |.  ..|.....||..||.||.|..  ||||| ||||||..| .|||
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpk..dftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviayl

MQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSL
|.| .|||..|..||. .. .|.||  |. || ..| .|
mkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP12_pd Subfamily DSP12 206-344 2.6e-40 132.3 In-house 4-143 (155) alignment 
Range on Protein: 206-344
Range on HMM: 4-143/155.0
QILPNLYLGSARDSANLESLAKLGIRYILNVTPN-LPNFFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAY
.|||.||||.... .. |.|..|.|  .| |. . ||.. .|.|  ..|.|.| |. .... ....||..||.|||...  ||||| ||||||||. .||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSL
||.| .|||..|..|||.||..|.|| .|. ||  ||.. 
lmkkeklslekAlklvkekkpeiepNegFleQLklfekmg
subfamily_DSP15_pd Subfamily DSP15 206-350 1.3e-37 123.2 In-house 4-145 (151) alignment 
Range on Protein: 206-350
Range on HMM: 4-145/151.0
QILPNLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKngdFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYL
..||.||||  ||| . | | .  |  ||.|  |  .....   ..|| |..||  |..||.|| |..||| .. ... .||||||||||||||..||||
kvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd...ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYl

MQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLRLEERH
|  ..|. .|| . .| ..|   ||| |  || ..|..   |.|.
mtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyrk
0036282 (Phosphotyrosine protein) phosphatases II 206-343 3.1e-32 107.0 In-house 14-168 (174) alignment 
Range on Protein: 206-343
Range on HMM: 14-168/174.0
QILPNLYLGSARDSaNLESLAKLGIRYILNVTPNLPN-------------FFEKNGDFHYKQIPISDHWSQNLSRfFPEAIEFIDEALSQ--NCGVLVHC
 |.|.|..|..  . ..| | .|||........  ..              .... ...|...|. ||   .||  . |...|..||||.  .. |||||
yitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

LAGVSRSVTVTVAYLMQKLHL-SLNDAYDLVKRKK---SNISPNFNFMGQLLDFERS
 |||.|. |. .|||| ...| || ||.|||....   ... ...... .| .||. 
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
0042113 (Phosphotyrosine protein) phosphatases II 206-343 2.1e-27 91.5 In-house 49-241 (245) alignment 
Range on Protein: 206-343
Range on HMM: 49-241/245.0
QILPNLYLGSARDSANLE----SLAKLGIRYILNVTPNLP--------------------------------------------NFFEKNGDFHYKQIPI
.| |.......  . ..|     | .|||..|...|.  .                                              .|.  ..|| ..|.
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

SDHWSQNLSRFFPEAIEFIDEALS--QNCGVLVHCLAGVSRSVTVTVAYLM-----QKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERS
 ||   .|.. . ...||...||.  .|  ||||| |||.|. |. .||||       | .|| .|.. ........ ...... .| .... 
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0051082 (Phosphotyrosine protein) phosphatases II 206-339 7.5e-27 89.2 In-house 10-148 (151) alignment 
Range on Protein: 206-339
Range on HMM: 10-148/151.0
QILPNLYLGSARDSANLESLAKLGIRYILNVTP-----NLPNFFEKNGdFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQ-NCGVLVHCLAGVSRSVT
.. ..||....  ...|| |..|||..|.|...     ..|......| .....||| |.. ..|. .|....||....|.. |  ||||| ||..|. |
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelg.ievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

VTVAYLMQkLHLSLNDAYDLVKRKKS-NISPNFNFMGQLLD
. ..|||  |..||..|.. ...|    . ||  |. ||..
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfa
subfamily_STYX_pd Subfamily STYX 206-342 3.4e-25 82.0 In-house 14-155 (166) alignment 
Range on Protein: 206-342
Range on HMM: 14-155/166.0
QILPNLYLG--SARDSANLESLAKLGIRYILNVTPNLPNFF-EKN--GDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTV
.||| |.||  ||   . || | | || .|. .  |.   .   |   .|.|  . ..|   .|. |..|.  ||||..|..   ||||  ||.||| ..
eilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaal

TVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFER
 .||.|.   |   .|.  |....  |.||  |. || ..| 
viayimetyglkyreafayvqerrfcinpnegfvsqlkeyea
0051429 (Phosphotyrosine protein) phosphatases II 206-344 3.2e-20 68.4 In-house 18-224 (272) alignment 
Range on Protein: 206-344
Range on HMM: 18-224/272.0
QILPNLYLGSAR----DSANLESLAKLGIRYILNVTPNL----PNFFEKNGDFHYKQIPISDHWSQNLSRFF----------------------------
...|.... |..    . |... |..|||..|.....       ...    ...| ..|| |.  .  . ..                            
vvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsag

--------------------PEAIEFIDEALSqNCGVLVHCLAGVSRSVTVTVAYLMQkLHLS--------------LNDAYDLVKRKKSNISPNFNFMG
                     . .|.... |. .  ||||| ||..|. || ...|.  | .|              | .|.. ....  .. ..  .. 
earevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

QLLDFERSL
.|..... |
flyeallel
0036941 (Phosphotyrosine protein) phosphatases II 206-343 6.2e-18 60.6 In-house 21-275 (297) alignment 
Range on Protein: 206-343
Range on HMM: 21-275/297.0
QILPNLYLGSARDSANLESLA----------------------------------------------------------KLGIRYILNVTPNLPNFFEK-
..||.|.||| . ....| |                                                           ..... |...|.  .. .|| 
ellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekc

----------------------------NGDFHYKQIPISD----------------HWSQNLSRFFPEAIEFIDEALS------QNCGVLVHCLAGVSR
                            ..|... .. ..|                    ..   . . ..||.....      ..  ||||| |||.|
aqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgR

SVTVTVAYLM--------QKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERS
| |. .|.||            ... .|.  ..... .. ...... .| ...  
sgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle
subfamily_DSP3_pd Subfamily DSP3 207-345 1.4e-32 106.5 In-house 14-158 (162) alignment 
Range on Protein: 207-345
Range on HMM: 14-158/162.0
ILPNLYLGSARDSANLESLAKLGIRYILNVTPN-L------PNfFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQ-NCGVLVHCLAGVSRSV
. |.||.| .  . . . |.|||| ..|| .   .      .. | |. ...|  ....|  . .||..| .| .|||||||| .  ||||| .||||| 
vypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgae.fykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

TVTVAYLMQKLHLSLNDAYDLVKrKKSNISPNFNFMGQLLDFERSLR
|. .|||| . ...|..|   |. || .| ||  |. || .....|.
tlvlayLmirrkmtlveairtvr.kkReilPneGFlkqLaeldeelk
subfamily_MSG5_pd Subfamily MSG5 207-344 3.9e-19 62.4 In-house 29-160 (165) alignment 
Range on Protein: 207-344
Range on HMM: 29-160/165.0
ILP-NLYLGSARdsaNLESLakLGIRYILNVTPNLPNFFEKNGDFHYKQIPIsDHWSQnLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYL
.|| .||| |     .|. |  | .  ..||. .....  .    .|  |   .| |. . . ...  . |  | |..  .||||  |.||| .. |||.
vlpeklylysep...klkel..lsfdlvinvakeindlellvpavkyyhiew.ehdsk.ivkdlsrltriihaatskrkkilvhcqcglsrsaslivayi

MQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSL
|.   |||.||||..| .  .|||.. .. ||...|  |
mkyynlslrdaydklksvaddispsiglifqlmeweval
0038934 (Phosphotyrosine protein) phosphatases II 208-345 2.5e-22 74.9 In-house 35-177 (194) alignment 
Range on Protein: 208-345
Range on HMM: 35-177/194.0
LPNLYLGSARDSANLESLAKLGIRYILNVTPN----LPNFFEKNGdFHYKQIPISDHWS----QNLSRFFPEAIEFIDEalSQNCGVLVHCLAGVSRSVT
...||  | .|  .. .| . ........| .     |. |||.| ..| ..|. |...    ..| ||.  . ||..|  .... |.||| ||..|. |
ieelyrfspedlvrylkllnvklglvidltnteryYdpeefekag.ieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGt

VTVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLR
. .|||...|..|...|..|...|. .. || ... .|| . . ||
lvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelr
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 210-345 2.1e-27 89.4 In-house 9-153 (154) alignment 
Range on Protein: 210-345
Range on HMM: 9-153/154.0
NLYLGSARDSANLESLAKLGIRYILNVTPNLPNFFEKN-GD------FHYKQIPISDHWSQNLSRFFPEAIEFIDEAL--SQNCGVLVHCLAGVSRSVTV
.||..|   . |   | .  |. ||||    .| | ..  |      ..| .. . |.  ... . .  | ||||.|.   .| .||||. .||||| ..
flyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaal

TVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLR
 ..|||.||..||  |. |.|  .  |.||  |. ||  ||. |.
lisylmdklkislslalellkdsryiikPnqGflkqleifekell
DSPc Dual specificity phosphatase, catalytic domain 211-342 4.1e-44 144.7 Pfam-A 1-132 (133) alignment 
Range on Protein: 211-342
Range on HMM: 1-132/133.0
LYLGSARDSAnLESLAKLGIRYILNVTPNLPN-FFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYLMQKL
|||||. ..  |. |.|||| ...||| . || .. |.....| .||. |......|....||.|||..| .... ||||| ||.||| |...||||.. 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

HLSLNDAYDLVKRKKSNISPNFNFMGQLLDFER
.||||.||..||...|.||||..|..|||..||
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 211-342 4.1e-44 144.7 In-house 1-132 (133) alignment 
Range on Protein: 211-342
Range on HMM: 1-132/133.0
LYLGSARDSAnLESLAKLGIRYILNVTPNLPN-FFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYLMQKL
|||||. ..  |. |.|||| ...||| . || .. |.....| .||. |......|....||.|||..| .... ||||| ||.||| |...||||.. 
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

HLSLNDAYDLVKRKKSNISPNFNFMGQLLDFER
.||||.||..||...|.||||..|..|||..||
nlslneAyefvkerrskispnagflrqLleyer
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 211-345 5e-26 84.5 In-house 6-142 (145) alignment 
Range on Protein: 211-345
Range on HMM: 6-142/145.0
LYLGSARDSANLESLAKLGIRYILNVT--PNLPNFFEKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYLMQK
|| |||  . ..  | .|||  |.|..    .     |. ...   |  .|  | .||. | |  .|||    .  ||.|||.|||||||||.||.||. 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

LHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLR
  ..| .|   |. ..    || .|. .||..|. |.
cnmtlseaarqvrsnrllaypnvtflknllnlekqlk
subfamily_DSP23_pd Subfamily DSP23 217-324 2.3e-11 38.6 In-house 19-125 (148) alignment 
Range on Protein: 217-324
Range on HMM: 19-125/148.0
RDSANLESLAKLGIRYILNVTPNLPNFFEKNGDFHYKQIPISDHWSQNLSRFfPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYLMQKLHLSLNDA
|  .... |. ||.||.. .| . .   |   .  .... | |.    | .   | .. ..|| ..|  | |||| |  |. |.   ||... .|.  .|
rlpdqyrylldlgvrylvslteegrphveatpnltlvrlriddyhppaleqv.vefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaea

YDLVKRKK
   |.|..
iaevrrlr
0049772 (Phosphotyrosine protein) phosphatases II 218-344 5e-33 110.5 In-house 159-273 (314) alignment 
Range on Protein: 218-344
Range on HMM: 159-273/314.0
DSANLESLAklgiryilnvtPNL--PNFFEKNGdFHYKQIPISDhWSQNLSRFFPEAIEFIDEAlSQNCGVLVHCLAGVSRSVT-VTVAYLMQKLHLSLN
. |.|| |            . |  |..||..| ..|..||..| .|..|...|.|..|||.|| ...  ||||| ||..|. | |..|||| .|..||.
taadlellk...........eelydpelferlg.ikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsle

DAYDLVKRKKSnISPNFNFMGQLLDFERSL
.|.. |..| . |.||..|. ||...|  |
ealedvrlkRp.inpnpgfieqleqyefil
0040439 (Phosphotyrosine protein) phosphatases II 220-344 2.6e-26 88.2 In-house 69-245 (249) alignment 
Range on Protein: 220-344
Range on HMM: 69-245/249.0
ANLESLAKLGIRYILNVTPNLPNFF-----------------------------------------EKNGDFHYKQIPISDHWSQNLSRFFPEAIEFIDE
.... | .|||..|...|.  .. .                                         ... ......|.. |   .... .|.....||..
dfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfiea

ALS------QNCGVLVHCLAGVSRSVTVTVAYLM-----QKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSL
...      ... ||||| |||.|. |. .||||      .|...| .|..|........ .|.... .|..... |
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
0039614 (Phosphotyrosine protein) phosphatases II 224-345 5.8e-23 77.2 In-house 120-289 (297) alignment 
Range on Protein: 224-345
Range on HMM: 120-289/297.0
SLAKLGIRYILNVTPNLPNF------------------------FEkNGD-------------------FHYKQIPisDHWSQNLSRFFPEAIEFIDEAL
 . ..|...|...|.  ..                         .. ...                   |.|  .|  ||   .... . |..|...|||
mvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkveh.ldgytvrtlevtnngesrtvthfqytgwp..dhgvppslellleflelvreal

S---QNCGVLVHCLAGVSRSVTVTVAYLM-----QKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSLR
.   ... ||||| |||.|. |. .||||      . .... .|.. ........ ...... .| |... |.
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
0045450 (Phosphotyrosine protein) phosphatases II 225-344 4.5e-24 81.2 In-house 127-303 (307) alignment 
Range on Protein: 225-344
Range on HMM: 127-303/307.0
LAKLGIRYILNVTPNLPNFFE--------------------------KNGDFHYKQIPISDH-----------------WSQNLSRFFPEAIEFIDEALS
| ..|...|...|.  .. .|                          . ..... .....|.                   .... .| |...||.|...
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

------QNCGVLVHCLAGVSRSVTVTVAYLMQKLH--------LSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSL
      ... ||||| |||.|. |. .|||| ...        ..| .|..|........ .|.... .| .... |
aleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0040438 (Phosphotyrosine protein) phosphatases II 225-344 9.6e-22 73.1 In-house 106-275 (317) alignment 
Range on Protein: 225-344
Range on HMM: 106-275/317.0
LAKLGIRYILNVTPNLPN--------------------------FFEkNGDFHYKQIPISDH----------------WSQNLSRFFPEAIEFIDEALSQ
. ..|...|...|.  ..                          ..| ...... .....|.                  ...   . . ..|.... ..
vweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----NCGVLVHCLAGVSRSVTVTVAYLM-----QKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFERSL
    .. ||||| |||.|. |. .||||     .. .... .|.. ........ ...... .| |... .
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalley
0043336 (Phosphotyrosine protein) phosphatases II 229-342 2.6e-17 58.6 In-house 112-274 (278) alignment 
Range on Protein: 229-342
Range on HMM: 112-274/278.0
G---------------------------------------------IRYILNVTPNLPNFFEKNGDFHYKQIPisDHWSQ-NLSRFFPEAIEFIDEALSQ
|                                             ... |.||..  ..  .   .||. .|  ||    .|| ..    ....   ..
gvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslsllldflkavrealeds

NCGVLVHCLAGVSRSVTVTVAYLM-----QKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFER
|  ||||| |||.|. |. ..||.       ....| .|.. ..... .. ...... .| ....
ngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0051299 (Phosphotyrosine protein) phosphatases II 231-332 3.1e-12 42.0 In-house 164-273 (288) alignment 
Range on Protein: 231-332
Range on HMM: 164-273/288.0
RYILNVTPN----LPNFFEKNGDFHYKQIPisDHWSQN-LSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYLM-----QKLHLSLNDAYDLV
 . | ||..     ...  .   |||...|  ||   . .. ..    ....   |... |.||| |||.|. |. ...|.     .. .... .|.  .
vrtlevtnldlldgdgesrtvthfhytnwp..dhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrl

KRKKSNISPNFN
.... .. ....
reqRpgmvqtpe
subfamily_Laforin_pd Subfamily Laforin 231-319 5.7e-08 25.8 In-house 59-147 (183) alignment 
Range on Protein: 231-319
Range on HMM: 59-147/183.0
RYILNVTPNLPNFFEKNGdFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYLMQKLHLSLNDA-YDL
||  |.   | ... ..| . |  .|. |  ...  . .|.|. ..   | .   | ||| ||| || .. . .|.  |. ||.   | |
rynenlpitlkklykeeg.layiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfl
0046845 (Phosphotyrosine protein) phosphatases II 232-329 1.6e-11 39.6 In-house 151-258 (284) alignment 
Range on Protein: 232-329
Range on HMM: 151-258/284.0
YILNVTPNL-PNFFEKNGDFHYKQIPisDHWSQNLSRFFPEAIEFIDEALSQ---NCGVLVHCLAGVSRSVTVTVAYLMQKL--------HLSLNDAYDL
. | .|..  ...  .   |||...|  ||     .. . | .....|.|..   .. ..||| |||.|. |. ...|. ..        .... .|.  
rtleltnlgytgesrtvthfhytswp..dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkr

VKRKKSNISP
..... .   
lreqRpgmvq
subfamily_PTPMT1_pd Subfamily PTPMT1 245-342 3.8e-15 50.7 In-house 70-166 (171) alignment 
Range on Protein: 245-342
Range on HMM: 70-166/171.0
EKNGdFHYKQIPISDHWSQNLSRFFPEAIEFIDEALSQNCGVLVHCLAGVSRSVTVTVAYLMQKLHLSLNDAYDLVKRKKSNISPNFNFMGQLLDFER
.|.|  .. |... |.  .       ...|||..  |.   | ||| || .|| |.  .|||.| .||...| . .|.|.. |  . . . .|  .|.
kklg.veqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyee
0047943 (Phosphotyrosine protein) phosphatases II 245-338 7.4e-14 47.3 In-house 125-265 (273) alignment 
Range on Protein: 245-338
Range on HMM: 125-265/273.0
EKNGD-----------------------------------------FHYKQIPisDHWSQNLSRFFPEAIEFIDEALS---QNCGVLVHCLAGVSRSVTV
...|.                                         |||. .|  ||        . | ||....||.   .|  |.||| |||.|. |.
leggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwp..dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtf

TVAYLM-----QKLHLSLNDAYDLVKRKKSNISPNFNFMGQLL
 ...|.      .  ... .|. |..... .. ...... .| 
ialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly
subfamily_PTPDC1_pd Subfamily PTPDC1 246-326 2.4e-06 22.1 In-house 80-157 (182) alignment 
Range on Protein: 246-326
Range on HMM: 80-157/182.0
KNGDFHYkQIPISDHWSQNLSRFFpEAIEFIDEALSQNcGVLVHCLAGVSRSVTVTVAYLMQKLHLSLNDAYDLVKRKKSN
..| ..| .....|. .. | | . . .  .. ||...  | ||| ||  |   .  .||. . .|. ..| .||. |...
eqgiyvy.nfgwkDygvasleriL.divkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpk
0050432 (Phosphotyrosine protein) phosphatases II 250-331 8.6e-11 37.2 In-house 202-285 (308) alignment 
Range on Protein: 250-331
Range on HMM: 202-285/308.0
FHYKQIPisDHWSQNLSRFFPEAIEFIDEALsQNCGVLVHCLAGVSRSVTVTVAYLM-----QKLHLSLNDAYDLVKRKKSNISPNF
|||.  |  ||   .  . . . .|.... | ... ..||| |||.|. |. ...|.     .. .... .|.  ..... .  ...
fhytnWp..dhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
PTPc_DSPc_SM00012 250-310 1.5e-06 23.8 In-house 5-66 (105) alignment 
Range on Protein: 250-310
Range on HMM: 5-66/105.0
FHYKQIPISdHWSQNLsrffPEAIEFIDEALSQNC------GVLVHCLAGVSRSVTVTVAYLMQKLH
.||...|   .. ..      . .|....  ...        |.||| |||.|. |....... . .
yhytgwpdh.gvPees....dsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqql
0048567 (Phosphotyrosine protein) phosphatases II 264-329 1.2e-07 26.3 In-house 55-123 (157) alignment 
Range on Protein: 264-329
Range on HMM: 55-123/157.0
NLSRFFPEAIEFIDEALSQNCGVLVHCLAGV---SRSVTVTVAYLMQKLHLSLNDAYDLVKRKKSNISP
 | ||.  . .|..    ... . ||| ||    .|..|.  .||. .|... ..|.....    .. |
ilyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvp