Gene Laforin in Homo sapiens

Synonym: EPM2, MELF, RP1-28C20.2, EPM2A

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily Laforin
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP034_AA protein Get Run
HsapP034_AA_154-320 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
CBM_20 Starch binding domain 19-105 8.9e-11 28.8 Pfam-A 17-82 (97) alignment 
Range on Protein: 19-105
Range on HMM: 17-82/97.0
ELLVVGSRPELGRWEPRGAVRLRPAGTaagdgalaLQEPGLWLGEVELAAEEaaqdgaepgrvdTFWYKFLKREPGGELSWEGnGPH
....||. ||||.|.|  |..|.   .         ..  || |.|.| |..            .. ||..|.. .|.  ||  |..
nvyivGnvpeLGnWdpakaiklsasee........tssyplWsgtvslpagt............eieyKyikkdsdgsvtWes.gen
0041856 (Phosphotyrosine protein) phosphatases II 140-305 4.8e-21 70.6 In-house 8-155 (182) alignment 
Range on Protein: 140-305
Range on HMM: 8-155/182.0
KHTTDFYFNIaghqamHYSRILPNIWLGSCPRQVE-----------HVTIKLKHELGITAVMNFQtewdivqnssgCNRYPEpmtpdtmiKLYREEGLAY
..   .....      ....|..|..|||.| .                ... .|||||.. |             . .|.         .|.  .|. |
sdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...........eelywp........ellerlgiqy

IWMPTPDMSTEGrvqmLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYI
...| ||...      |.... .... ||.|. |.|||.|||||. . |. .| ...|..|...  ..  .|| . |
lylpwpDhgvpd....ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvi
subfamily_Laforin_pd Subfamily Laforin 147-328 4.2e-113 368.5 In-house 1-179 (183) alignment 
Range on Protein: 147-328
Range on HMM: 1-179/183.0
FNIAGHQAMHYSRILPNIWLGSCPRQVEHVtIKLKHElGITAVMNFQTEWDIVQNSSGCNRYPEPMtPDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLP
||....|.||||.||.|||||||||.|||| |.||.| |||||...|||.|||.||||..||.|.. |.|..|||.||||||||.||.|.|||.||..||
fnverqqimhyskileniwlgscprlvehv.idlkse.gitavislqtesdivknssgiyrynenl.pitlkklykeeglayiwlptedlstesrvenlp

QAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDEEALARAQEDFFQKFGKVRSSV
|||.|||||||||||||||||||||||||.|||.||||.||.|.||||||.||||.||||||||.||..||.||||.|.| .
qavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvyideealiraekdfiqkfgqvksrl
0044763 (Phosphotyrosine protein) phosphatases II 149-305 5.6e-27 89.9 In-house 15-155 (178) alignment 
Range on Protein: 149-305
Range on HMM: 15-155/178.0
IAGHQAMHYSRILPNIWLGSCPRqveHVTIKLKHELGITAVMNFQTEWDIVQNSsgcnrypepmtpdTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQA
. . . ...|.|||...|||.|       ..| .|||||.. |. .|    ...             .  . ..|.|. |...|.||...    ......
lersdyinaseilpglylgslpp...addlellkelgithivnlteelelgflk.............cdpywpeeagiqylhipipDhgvpdllehflef

VCLLHALL-EKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPaVYI
| .....| |||. |.|||.||||||.. |. .| ...|..| ..  .. ..|| ...
vefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivp
subfamily_PTPMT1_pd Subfamily PTPMT1 153-310 1.5e-21 71.6 In-house 16-158 (171) alignment 
Range on Protein: 153-310
Range on HMM: 16-158/171.0
QAMHYSRILPNIWLGSCPrqVEHVTIKLKHELGITAVMNFQTEWDIVQNSSGCNRYPEPmtpdtmiklyreeGLAYIWMPTPDMSTEGRVQMLPQAVCLL
.  .|.||  .. ||  |  ... . .| ..  . ||.... |...   .   ... .              |. .. ..|.|.  .  .. | ..| ..
krnwydriDdtvilGalP..frslikeLiekenvkavvslneeyelkalansteewkkl.............gveqlqlatvDfteapdleklekgvefi

HALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDEEAL
.   .||. |||||.|| |||.. |  .| .   ... . . .| .||. . . .. .
ekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqw
0051429 (Phosphotyrosine protein) phosphatases II 153-308 8e-15 50.7 In-house 15-212 (272) alignment 
Range on Protein: 153-308
Range on HMM: 15-212/272.0
QamhYSRILPN-IWLGSCPRQVEHVTIKLKHELGITAVMNFQTEWDIVQnsSGCNRYPepmtpdtmiklyreEGLAYIWMPTPDMSTEGRVQML------
    .....|. ......| .. .  ..  .||||... .. .|. . .   .| ||.              .|. |...|..|.|..   ..       
y...grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgr..lkcdryw..............pgirylhlpilddsaptilygalrvtll

------------------------------------------PQAVCLLHALLEkGHIVYVHCNAGVGRSTAAVCGWLQYvMGWN--------------L
                                           . . ||..||. |. |.|||.||..|.  .|. .| . .|..              |
seellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyl

RKVQYFLMAKRPAVYIDEE
...   |.|.||..  .||
eeaveelraqrpgavqtee
0046846 (Phosphotyrosine protein) phosphatases II 155-303 7.5e-25 83.1 In-house 10-155 (176) alignment 
Range on Protein: 155-303
Range on HMM: 10-155/176.0
MHYSRILPNIWLGSCP--------RQVEHVTIKLKHElGITAVMNFQTEWDIVQNSsgCNRYPEPmtpdtmiklYREEGLAYIWMPTPDMSTEGRvQMLP
.....|..|..|||.|        |....    ||.. |||||.|...|... . .  | .|..          ....|. |...|.||...    . |.
ldldyinanlilgsrpiatqgplprtladflemlkel.gitavvnlteevelgrlk..cpnywpe.........leklgiqylhlpwpDhgvpdl.elll

QAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYV-MGWNLRKVQYFLMAKRP-AV
... ...  |..|. |.||| ||.||. . |. .| .  .|... .. ... ..||  .
ellefirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplga
0036282 (Phosphotyrosine protein) phosphatases II 155-303 8.4e-24 79.6 In-house 10-152 (174) alignment 
Range on Protein: 155-303
Range on HMM: 10-152/174.0
MHYSRILPNIWLGSCPRQvehvTIKLKHELGITAVMNFQTEWDivQNSSGCNRYPEPmtpdtMIKLYREEGLAYIWMPTPDMSTEGRVQmLPQAVCLLHA
.. |.|.|....|..| .     ... .|||||.| .. .|.    .. .| .|        . . ....|. |...|.||...    . | ..|.... 
ldlsyitprliagqgpla....fwemlkelgittvvmlleeke..lglykcinywpe.....lredlerlgiqylylpwpDhgvpdlsi.llefvkfvee

LLEK--GHIVYVHCNAGVGRSTAAVCGWLQYVMGW-NLRKVQYFLMAKR---PAV
 |..  |. |.|||.|||||. . |. .| ..... .|... ... ..|   | .
alsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgm
0051082 (Phosphotyrosine protein) phosphatases II 155-305 3.5e-22 74.0 In-house 6-137 (151) alignment 
Range on Protein: 155-305
Range on HMM: 6-137/151.0
MHYSRILPNIWLGSCPRQvehVTIKLKHELGITAVMNFQTEWDIVqnssgcnrypepmtpdTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHA
 ..|.. ........| .     ..| .||||....|. .|. .                 .. ....|.|. ....| .|... |  ....... .|..
infsyvtgglyrsggpla...dflellkelgiktivnlrseeerg................ycpeylpelgievlhipildwpdpglplsfdavleflel

LLEK-GHIVYVHCNAGVGRSTAAVCGWLQYvMGWNLRKVQYFLMAKRPAVYI
||.| .. |.|||.||.||. . |. .| . .|..| ..  ....||| |..
lldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvq
subfamily_DSP3_pd Subfamily DSP3 155-284 2.4e-07 24.5 In-house 9-122 (162) alignment 
Range on Protein: 155-284
Range on HMM: 9-122/162.0
MHYSRILPNIWLGSCPRQVEHvtIKLKhELGITAVMNfqtewdivqNSSGcnRYpepMTPDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLH-
 ..  . |....|      ..   ||| .|||| |.|          . |  |.   .. ||  . |.. .. |. ..  |. .    .   .|.  .. 
kevdevypklyvgdeavakdk..skLk.klGithvln.........aaeg..rf...skvdtgaefykdleikylGlevdDvpefdlskyFetaakfide

ALLEKGHIVYVHCNAGVGRSTAAVCGWLQYV
|| .|   |.|||..|| ||.. |  .|  .
alsqkegkvlvhcvvGvsRsatlvlayLmir
0037934 (Phosphotyrosine protein) phosphatases II 156-302 6.2e-16 54.1 In-house 38-222 (243) alignment 
Range on Protein: 156-302
Range on HMM: 38-222/243.0
HYSRILPNIWLGSCPRQVEHVT-----IKLKHELGITAVMNFQTEWDIvqNSSGCNRYPE-PMTPDTM------------------------IKLYREEG
 .....|.......| .  .       ... .|||||.. .. ....   .  .| .|   ..| ...                        .. .  ..
nliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvEl..grekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlv

LAYIWMPTPD----MSTEGRVQMLPQAVCLLHA-----LLEKGHIVYVHCNAGVGRSTAAVCGWLQYVM-GWNLRKVQYFLMAKRPA
  | ..| ||     |.|  ...| ..   ...      | .|. |.||| |||||. . .. .| . . |..| ..  .| ..|| 
ihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpg
0048179 (Phosphotyrosine protein) phosphatases II 157-307 3.1e-25 84.0 In-house 4-131 (144) alignment 
Range on Protein: 157-307
Range on HMM: 4-131/144.0
YSRILPNIWLGSCPRQVEhvtIKLKHELGITAVMNFQTEWDIVQNSSGcnrypepmtpdtmiklyreeGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALL
.|.|||...|||.|  ..   ..| ..||||.| |...|..                           |. |...|.||...    ..|.... .....|
pseilpglylgslptald...lellkklgittvinlteeyepeflere....................giqylhlpwpDhgvpdllellleflefieeal

EKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDE
|.|. |.|||.|||||... |. .| ...|..| .. ... ..|| ... .
eeggpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrsrrpgavpnp
0048076 (Phosphotyrosine protein) phosphatases II 157-307 3.9e-25 83.6 In-house 4-129 (145) alignment 
Range on Protein: 157-307
Range on HMM: 4-129/145.0
YSRILPNIWLGSCPRQVEhvtIKLKHELGITAVMNFqtewdivqnssgcnrypepmtpDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALL
.|.|||...|||.|  ..   ..| ..||||.| |.                       ....|. ..|. |...|.||...    ..|.... .....|
pseilpglylgslptald...lellkdlgittvlnl......................tselellerlgiqylylpwpDhgvpdllellleflefieeal

EKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDE
..|. |.|||.|||||... |. .| . .|..| ..  .. ..|| . . .
keggpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrsqrpgavpnp
0042113 (Phosphotyrosine protein) phosphatases II 157-303 1.2e-18 62.9 In-house 47-225 (245) alignment 
Range on Protein: 157-303
Range on HMM: 47-225/245.0
YSRILPNIWLGSCPRQVehvTIK----LKHELGITAVMNFQTEWDivQNSSGCNRYPEPmtPDTM----------------------------IKLYREE
 .|| |.......| .    |..    . .|||||.. .. .|..   .  .| .|  .   ...                             . .  |
gyritpkfiatqgPlpe...tvedfwrmlwelgittivmLteeee..lgrvkcaqywpl..gesltygdftvtllseehlddytvrtlevtnlgddesre

GLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLE--KGHIVYVHCNAGVGRSTAAVCGWLQ-----YVMGWNLRKVQYFLMAKRPAV
.. | ..| ||...   ...| ... ...  |.  ... |.|||.|||||. . .. .|      . .|..| .. ..|  .|| .
vihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpga
0043147 (Phosphotyrosine protein) phosphatases II 158-304 5.2e-20 67.3 In-house 16-144 (172) alignment 
Range on Protein: 158-304
Range on HMM: 16-144/172.0
SRILPNIWLGSCP-RQVEHVTIKLKHELGITAVMNFQTEwdivqnssgcnrypepmtpDTMIKLYREEGLAYIWMPTPDMSTEgRVQMLPQAVCLLHA--
..| .... .  | |   .  ... .|||||.. |  ..                    .  .|. ..|. |...| ||...    ..|.... ...   
yyipdrfiatqgplrntladfwrmlkelgithivnltel...................lydpellerlgiqylylpwpDhgvp.llellleflefidell

LLEKGHIVYVHCNAGVGRSTAAVCGWLQYvMGWNLRKVQYFLMAKRPAVY
.|..|. |.||| |||||. . |. .| . .|..| ..  .. .||| . 
alspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgav
PTPc_motif_SM00404 158-303 6.2e-18 60.0 In-house 3-124 (140) alignment 
Range on Protein: 158-303
Range on HMM: 3-124/140.0
SRILPNIWLGSCPRQVehvTIKLKHELGITAVMNFQTEWDIVqnssgcnrypepmtpdtmiklYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLE
|||||...|||.....     .|. .||||.|.| ..| ..                      . ..|  ....|  |  ..  .. |....  ...  .
srilphlylgskskaq...npallkklgithvinvteevslt.....................kensgfqilqiplddnekdklskyldkvldfienaek

KGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV
||. |.||| ||| || . .. .| . ....|... .|.  .||..
kggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerRpii
0039614 (Phosphotyrosine protein) phosphatases II 162-303 2.6e-14 48.8 In-house 5-271 (297) alignment 
Range on Protein: 162-303
Range on HMM: 5-271/297.0
PNIWLGSCPRQVEHVTIKLKHElGITAVMNFQTEWDIV------------QNSSGCNRYP-EPMTPDTMIKLYREEG----LAYI---------------
.. .|.|.| ....... |..|   .  . ...|.  .            ...  .|||.  .. .....||  |.|    . ||               
rdallesipiplsvldllllle.kansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkf

--------------------------------------------------------------------------------------WMPTPDMSTEGRVQ
                                                                                      ... ||...   ..
IatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppsle

MLPQAVCLLHALLE---KGHIVYVHCNAGVGRSTAAVCGWLQ-----YVMGWNLRKVQYFLMAKRPAV
 | ... |..  |.   ||. |.|||.|||||. . .. .|      .  |... ..  .|  .|| .
llleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpga
DSPc Dual specificity phosphatase, catalytic domain 164-304 3.1e-15 51.2 Pfam-A 1-118 (133) alignment 
Range on Protein: 164-304
Range on HMM: 1-118/133.0
IWLGSCPRQVehvtIKLKHELGITAVMNFQTEWDIVqnssgcnrypepmtpdtmiKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVY
..|||....      .|. .||||.|.| ..| .                     ... ..   |...|  |....  .. |..||  .... .||. |.
lylgskstas....lalleklgitlvinvtkevpnn...................naikkseieylripvedetetkiskeleeavefiekaeqkgkkvl

VHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVY
|||.||. || . .. .| . ....|..  .|.  .|... 
VHCqaGisRSatliiaYlmktknlslneAyefvkerrskis
DSPc Dual specificity phosphatase, catalytic domain 164-304 3.1e-15 51.2 In-house 1-118 (133) alignment 
Range on Protein: 164-304
Range on HMM: 1-118/133.0
IWLGSCPRQVehvtIKLKHELGITAVMNFQTEWDIVqnssgcnrypepmtpdtmiKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVY
..|||....      .|. .||||.|.| ..| .                     ... ..   |...|  |....  .. |..||  .... .||. |.
lylgskstas....lalleklgitlvinvtkevpnn...................naikkseieylripvedetetkiskeleeavefiekaeqkgkkvl

VHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVY
|||.||. || . .. .| . ....|..  .|.  .|... 
VHCqaGisRSatliiaYlmktknlslneAyefvkerrskis
0049772 (Phosphotyrosine protein) phosphatases II 168-320 4.8e-22 74.5 In-house 155-272 (314) alignment 
Range on Protein: 168-320
Range on HMM: 155-272/314.0
ScprqvehvtiklkhelgitavmNFQTEWDIVQNSsgcnrypepmTPDTMIKLYREEGLAYIWMPTPDMSTEgRVQMLPQAVCLLHALlEKGHIVYVHCN
                       |. |..|. .            .  .  .|. ..|. |...|.|| |.    ....... ..... .||. |.|||.
g......................neptaadlellk..........eelydpelferlgikylripvpDgsap.lledfdeflefieea.dkggpvlvHCk

AGVGRST-AAVCGWLQYVMGWNLRKVQYFLMAKRPaVYIDEEALaRAQEDFFQK
||.||.. ..|...| . .|..|...  ....||| ... . .. . .|.. ..
aGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfi.eqleqyefi
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 178-303 2.5e-07 24.3 In-house 26-130 (148) alignment 
Range on Protein: 178-303
Range on HMM: 26-130/148.0
IKLKHELGITAVMNFQTEWDIVQNSSgcnrypepmtpdtmiklyreeGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAV
..  ..||.|...| . | | . .                       |. |. ..  |   |   .. ....  ..   ..|. | ||.. || ||.| .
lealkalgvtrivnatkerdnaldqr.....................gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssala

CGWLQYVMGWNLRKVQYFLMAKRPAV
  ||       |..   .   ||. |
llwlidfkrvslkealalvkskrryv
0049260 (Phosphotyrosine protein) phosphatases II 179-307 8.6e-18 59.9 In-house 27-136 (152) alignment 
Range on Protein: 179-307
Range on HMM: 27-136/152.0
KLKHELGITAVMNFQTEWDivQNSSGCNRYPepmtpdtmiklyreeglAYIWMPTPDMSTEGRVQMLPQAVCLLHA-LLEKGHIVYVHCNAGVGRSTAAV
.. .|||||.. .  .. .   .  .|..|.                  |...|.||...    |.|.... ...  .|.||. |.||| |||||. . |
rmlkelgittivmltelle..lgklkceqyi.................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

CGWLQYvMGWNLRKVQYFLMAKRPAVYIDE
. .| . .|..| ..  .. .||| ... .
aaylml.lgvsleeavalvrekRpgavpnp
subfamily_PTPDC1_pd Subfamily PTPDC1 181-305 6.9e-09 30.4 In-house 42-160 (182) alignment 
Range on Protein: 181-305
Range on HMM: 42-160/182.0
KHELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTmiklYREEGLAYIWMPTPDMSTEGRVQMLpQAVCLLHALLEKGhIVYVHCNAGVGRSTAAVCGW
  | ||.||.|.|.. .  .  .| ..      ..     . |.|...  .. .| ..    ..| . | ...  |..|  | ||| || ||    .. .
fkesgikavinLqekgehasCGagleesGfsYdlea....lmeqgiyvynfgwkDygvasleriL.divkvvafalqeg.kvavhChaGlGrtGvliacy

LQYVMGWNLRKVQYFLMAKRPAVYI
| |.   .  |   .. .|||    
lvyakrltaekaiklvrskrpksiq
PTEN_1 182-311 2.6e-15 51.7 In-house 64-178 (196) alignment 
Range on Protein: 182-311
Range on HMM: 64-178/196.0
HELGITAVMNFQTEWDIvqnssgcnrypepMTPDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALL--EKGHIVYVHCNAGVGRSTAAVCG
.| |||.|.|.  | ..             ....   ......|. |. .| .|  .    ...  .. . ..||  ..|..|.||| ||.|||   |. 
kedgitlvvnlseeeel.............sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa

WLQYVMGWNLRKVQYFLMAKRPAVYIDeealA
.| | .... ..   .. .|||.. .      
yLmykgkltadeAlelvrekRppgapn....s
subfamily_DSP15_pd Subfamily DSP15 186-301 1.7e-07 25.4 In-house 28-120 (151) alignment 
Range on Protein: 186-301
Range on HMM: 28-120/151.0
ITAVMNFQTewdivqnssgcnrypepmtpdTMIKLYREegLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVM
|| ... .                         || ..  . |  ..  | .     ... ..| ..|.   |.. |.||| ||| ||.  |  .|  |.
ithilsvhd.....................nakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvt

GWNLRKVQYFLMAKRP
  | |..  .. |.| 
elnwrdalevikaaRs
0040438 (Phosphotyrosine protein) phosphatases II 193-303 1.1e-11 40.1 In-house 34-258 (317) alignment 
Range on Protein: 193-303
Range on HMM: 34-258/317.0
QTEWDIVQNSSGCNRYPEPMTPD-----------------------------------------------------------------------------
 ... . ... . ||||  .  |                                                                             
tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwp

------------TMIKLYREEGLAYIWMPTPDM----------------STEGRVQMLPQAVCLLHALLEK----GHIVYVHCNAGVGRSTAAVCGWLQ-
            |... . ..|  . ...  |.                   |  . . . . .|.|. |.    |. | |||.|||||. . .. .|  
lgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylml

----YVMGWNLRKVQYFLMAKRPAV
    . .|... .. ..| ..|| .
eqlekeggvdveeavkelreqRpga
0040439 (Phosphotyrosine protein) phosphatases II 200-304 1.6e-12 43.0 In-house 9-229 (249) alignment 
Range on Protein: 200-304
Range on HMM: 9-229/249.0
QNSSGCNRYPEPMTPD-TMI--------------------------------------------------------------------------------
...  .||||  . .| ...                                                                                
penkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsley

------------------------KLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLE------KGHIVYVHCNAGVGRSTAAVCGWLQ-----Y
                        .||  | . . ... .|.   |  . ..... ...|...      ||. |.|||.|||||. . .. .|      .
gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlek

VMGWNLRKVQYFLMAKRPAVY
  |..|  .  .|  .|| . 
elgvdleeavkllrsqRpgav
subfamily_DSP6_pd Subfamily DSP6 215-291 8.3e-08 25.9 In-house 49-125 (158) alignment 
Range on Protein: 215-291
Range on HMM: 49-125/158.0
DTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRK
.   |   .. | |  .|  |  ..   ...|.|. ..    .|   | ||| ||. || . .  .|   .   | .
nlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslnd
subfamily_STYX_pd Subfamily STYX 216-306 2e-09 30.7 In-house 53-143 (166) alignment 
Range on Protein: 216-306
Range on HMM: 53-143/166.0
TMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYID
..||   .. . |. .   | ..|  .. ||.   ..   |.||  | || |||. ||.| | ...   .| . |.   ..  .|  .  .
nlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpn
0045098 (Phosphotyrosine protein) phosphatases II 217-302 1.7e-13 46.1 In-house 147-252 (278) alignment 
Range on Protein: 217-302
Range on HMM: 147-252/278.0
MIKLYREEGLAYIWM-PTPDMSTEGRV--QMLPQAVCLLHALLE--------------KGHIVYVHCNAGVGRSTAAVCGWLQYVM---GWNLRKVQYFL
. . . . |. .... | ||...      . . ...  ... |.              .|. |.|||.|||||. . |. .| . .   |..| ..  .|
eredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkel

MAKRPA
  .|| 
rsqRpg
0038934 (Phosphotyrosine protein) phosphatases II 219-306 3.3e-15 51.7 In-house 73-162 (194) alignment 
Range on Protein: 219-306
Range on HMM: 73-162/194.0
KLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEK--GHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYID
... . |. |. .|.||  |    ..| . . |..  |..  |..|.||| ||.||.   |. .| |..|.....  ...  ||| ... 
eefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipn
subfamily_DSP10_pd Subfamily DSP10 220-303 1.2e-09 32.3 In-house 53-136 (159) alignment 
Range on Protein: 220-303
Range on HMM: 53-136/159.0
LYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV
 ..||.| |  .|  | |..   |   .|.  ..   .||. | |||.||. ||.. | ..| . .. .|..   |   |||..
efeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpii
subfamily_Slingshot_pd Subfamily Slingshot 221-303 7.7e-06 19.4 In-house 58-140 (169) alignment 
Range on Protein: 221-303
Range on HMM: 58-140/169.0
YREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV
. .| ..|. .   | ...  ..   ..   ...  .||  | |||  || ||...|  .     |..| .   ..  .|  .
ffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvi
0043336 (Phosphotyrosine protein) phosphatases II 223-303 2.7e-10 35.7 In-house 173-259 (278) alignment 
Range on Protein: 223-303
Range on HMM: 173-259/278.0
EEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLE-KGHIVYVHCNAGVGRSTAAVCGWLQ-----YVMGWNLRKVQYFLMAKRPAV
 ... | ... ||...   ...| . .  ..  || ... |.|||.|||||. . .. .|      .  |..| ..  .|  .||  
rtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpga
subfamily_DSP14_pd Subfamily DSP14 224-303 9.3e-07 22.9 In-house 48-127 (157) alignment 
Range on Protein: 224-303
Range on HMM: 48-127/157.0
EGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV
...... .|  |....  .. . ...  .... .||. . ||| ||| || . .  .|      .||.    . ..|| .
kdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpii
subfamily_DSP1_pd Subfamily DSP1 225-302 3e-07 24.7 In-house 61-138 (163) alignment 
Range on Protein: 225-302
Range on HMM: 61-138/163.0
GLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPA
 . | ...  | ...   ... ...  ...  .|.  |..||.||. ||.. .  .|     ..| .   |   .|. 
lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsi
subfamily_DSP19_pd Subfamily DSP19 226-303 2.7e-09 31.6 In-house 56-133 (152) alignment 
Range on Protein: 226-303
Range on HMM: 56-133/152.0
LAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV
. |  ..  | . .  ...|..|.  ..  ..|  .|.||||||| ||.. | ..|      .|..    . ..||..
ftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpci
0047943 (Phosphotyrosine protein) phosphatases II 227-306 2.5e-09 32.5 In-house 170-257 (273) alignment 
Range on Protein: 227-306
Range on HMM: 170-257/273.0
AYIWMPTPDMSTEGRVQMLPQAVCLLHALLE---KGHIVYVHCNAGVGRSTAAVCGWLQ-----YVMGWNLRKVQYFLMAKRPAVYID
 . ... ||...   ...| . . |..  ||   ... |.|||.|||||. . .. .|      .  |... .. ..|  .|| . . 
hfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqt
0051299 (Phosphotyrosine protein) phosphatases II 227-305 6e-08 27.9 In-house 186-270 (288) alignment 
Range on Protein: 227-305
Range on HMM: 186-270/288.0
AYIWMPTPDMSTEGRVQMLPQAVCLLHAL-LEKGHIVYVHCNAGVGRSTAAVCGWLQ-----YVMGWNLRKVQYFLMAKRPAVYI
 . ..  ||...   ...| . . |..     .|. |.|||.|||||. . .. .|      .  |... ..  .|  .|| . .
hfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvq
subfamily_MKPLT_pd Subfamily MKPLT 227-303 2.4e-07 24.4 In-house 67-143 (164) alignment 
Range on Protein: 227-303
Range on HMM: 67-143/164.0
AYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV
 |  . . | |.|   . | .|  .|   .. |  |.|||. |. ||...   .|    || |..   .|  .|  |
eYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsiv
subfamily_MKPLV_pd Subfamily MKPLV 227-303 2.4e-07 24.4 In-house 67-143 (164) alignment 
Range on Protein: 227-303
Range on HMM: 67-143/164.0
AYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV
 |  . . | |.|   . | .|  .|   .. |  |.|||. |. ||...   .|    || |..   .|  .|  |
eYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsiv
0045450 (Phosphotyrosine protein) phosphatases II 228-304 1.7e-11 39.9 In-house 200-287 (307) alignment 
Range on Protein: 228-304
Range on HMM: 200-287/307.0
YIWMPTPDMSTEGRVQMLPQAVCLLHALLE---KGHIVYVHCNAGVGRSTAAVCGWLQYVMG--------WNLRKVQYFLMAKRPAVY
...   ||...   ...| . . .... ||   ||. |.|||.|||||. . .. .| ....        ..|...  .| ..|| . 
fhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgav
0050432 (Phosphotyrosine protein) phosphatases II 228-307 2.9e-09 32.1 In-house 202-285 (308) alignment 
Range on Protein: 228-307
Range on HMM: 202-285/308.0
YIWMPTPDMSTEGRVQMLPQAVCLLHALLeKGHIVYVHCNAGVGRSTAAVCGWLQ-----YVMGWNLRKVQYFLMAKRPAVYIDE
. ..  ||...   ...| . . |..  | .|. ..|||.|||||. . .. .|      .  |... .. ..|  .|| . ...
fhytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0046845 (Phosphotyrosine protein) phosphatases II 228-305 1.8e-08 29.6 In-house 170-258 (284) alignment 
Range on Protein: 228-305
Range on HMM: 170-258/284.0
YIWMPTPDMSTEGRVQMLPQAVCLLHALLEK---GHIVYVHCNAGVGRSTAAVCGWLQYVM--------GWNLRKVQYFLMAKRPAVYI
. ... ||...   .. | . . |.. |||.   |. . ||| |||||. . .. .| . .        |... .. ..|  .||    
fhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvq
subfamily_DSP12_pd Subfamily DSP12 231-308 1.4e-10 35.8 In-house 54-131 (155) alignment 
Range on Protein: 231-308
Range on HMM: 54-131/155.0
MPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDEE
..  |. .|  .. |..||  ..  ||..  |.|||.||| || ..|  .| .  ...| |   .. .|.| ..  | 
iqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNeg
0036941 (Phosphotyrosine protein) phosphatases II 231-305 2.9e-08 28.8 In-house 176-261 (297) alignment 
Range on Protein: 231-305
Range on HMM: 176-261/297.0
MPTPDMSTEGRVQMLPQAVCLLHALLE---KGHIVYVHCNAGVGRSTAAVCGWLQ--------YVMGWNLRKVQYFLMAKRPAVYI
.  ||...   .. | . . |..  |.   .|. |.|||.|||||| . .. .|         .  |... ..  .|. .|| .  
tgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavq