Gene Laforin in Homo sapiens

Synonym: EPM2, MELF, RP1-28C20.2, EPM2A

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily Laforin
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP034_AA protein Get Run
HsapP034_AA_154-320 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
CBM_20 Starch binding domain 19-105 8.9e-11 28.8 Pfam-A 17-82 (97) alignment
Range on Protein: 19-105
Range on HMM: 17-82/97.0
ELLVVGSRPELGRWEPRGAVRLRPAGTaagdgalaLQEPGLWLGEVELAAEEaaqdgaepgrvdTFWYKFLKREPGGELSWEGnGPH
....||. ||||.|.|  |..|.   .         ..  || |.|.| |..            .. ||..|.. .|.  ||  |..
nvyivGnvpeLGnWdpakaiklsasee........tssyplWsgtvslpagt............eieyKyikkdsdgsvtWes.gen

0041856 (Phosphotyrosine protein) phosphatases II 140-305 4.8e-21 70.6 In-house 8-155 (182) alignment
Range on Protein: 140-305
Range on HMM: 8-155/182.0
KHTTDFYFNIaghqamHYSRILPNIWLGSCPRQVE-----------HVTIKLKHELGITAVMNFQtewdivqnssgCNRYPEpmtpdtmiKLYREEGLAY
..   .....      ....|..|..|||.| .                ... .|||||.. |             . .|.         .|.  .|. |
sdilpydhsr......dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt...........eelywp........ellerlgiqy

IWMPTPDMSTEGrvqmLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYI
...| ||...      |.... .... ||.|. |.|||.|||||. . |. .| ...|..|...  ..  .|| . |
lylpwpDhgvpd....ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvi

subfamily_Laforin_pd Subfamily Laforin 147-328 4.2e-113 368.5 In-house 1-179 (183) alignment
Range on Protein: 147-328
Range on HMM: 1-179/183.0
FNIAGHQAMHYSRILPNIWLGSCPRQVEHVtIKLKHElGITAVMNFQTEWDIVQNSSGCNRYPEPMtPDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLP
||....|.||||.||.|||||||||.|||| |.||.| |||||...|||.|||.||||..||.|.. |.|..|||.||||||||.||.|.|||.||..||
fnverqqimhyskileniwlgscprlvehv.idlkse.gitavislqtesdivknssgiyrynenl.pitlkklykeeglayiwlptedlstesrvenlp

QAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDEEALARAQEDFFQKFGKVRSSV
|||.|||||||||||||||||||||||||.|||.||||.||.|.||||||.||||.||||||||.||..||.||||.|.| .
qavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvvyideealiraekdfiqkfgqvksrl

0044763 (Phosphotyrosine protein) phosphatases II 149-305 5.6e-27 89.9 In-house 15-155 (178) alignment
Range on Protein: 149-305
Range on HMM: 15-155/178.0
IAGHQAMHYSRILPNIWLGSCPRqveHVTIKLKHELGITAVMNFQTEWDIVQNSsgcnrypepmtpdTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQA
. . . ...|.|||...|||.|       ..| .|||||.. |. .|    ...             .  . ..|.|. |...|.||...    ......
lersdyinaseilpglylgslpp...addlellkelgithivnlteelelgflk.............cdpywpeeagiqylhipipDhgvpdllehflef

VCLLHALL-EKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPaVYI
| .....| |||. |.|||.||||||.. |. .| ...|..| ..  .. ..|| ...
vefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivp

subfamily_PTPMT1_pd Subfamily PTPMT1 153-310 1.5e-21 71.6 In-house 16-158 (171) alignment
Range on Protein: 153-310
Range on HMM: 16-158/171.0
QAMHYSRILPNIWLGSCPrqVEHVTIKLKHELGITAVMNFQTEWDIVQNSSGCNRYPEPmtpdtmiklyreeGLAYIWMPTPDMSTEGRVQMLPQAVCLL
.  .|.||  .. ||  |  ... . .| ..  . ||.... |...   .   ... .              |. .. ..|.|.  .  .. | ..| ..
krnwydriDdtvilGalP..frslikeLiekenvkavvslneeyelkalansteewkkl.............gveqlqlatvDfteapdleklekgvefi

HALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDEEAL
.   .||. |||||.|| |||.. |  .| .   ... . . .| .||. . . .. .
ekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqw

0051429 (Phosphotyrosine protein) phosphatases II 153-308 8e-15 50.7 In-house 15-212 (272) alignment
Range on Protein: 153-308
Range on HMM: 15-212/272.0
QamhYSRILPN-IWLGSCPRQVEHVTIKLKHELGITAVMNFQTEWDIVQnsSGCNRYPepmtpdtmiklyreEGLAYIWMPTPDMSTEGRVQML------
    .....|. ......| .. .  ..  .||||... .. .|. . .   .| ||.              .|. |...|..|.|..   ..       
y...grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgr..lkcdryw..............pgirylhlpilddsaptilygalrvtll

------------------------------------------PQAVCLLHALLEkGHIVYVHCNAGVGRSTAAVCGWLQYvMGWN--------------L
                                           . . ||..||. |. |.|||.||..|.  .|. .| . .|..              |
seellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyl

RKVQYFLMAKRPAVYIDEE
...   |.|.||..  .||
eeaveelraqrpgavqtee

0046846 (Phosphotyrosine protein) phosphatases II 155-303 7.5e-25 83.1 In-house 10-155 (176) alignment
Range on Protein: 155-303
Range on HMM: 10-155/176.0
MHYSRILPNIWLGSCP--------RQVEHVTIKLKHElGITAVMNFQTEWDIVQNSsgCNRYPEPmtpdtmiklYREEGLAYIWMPTPDMSTEGRvQMLP
.....|..|..|||.|        |....    ||.. |||||.|...|... . .  | .|..          ....|. |...|.||...    . |.
ldldyinanlilgsrpiatqgplprtladflemlkel.gitavvnlteevelgrlk..cpnywpe.........leklgiqylhlpwpDhgvpdl.elll

QAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYV-MGWNLRKVQYFLMAKRP-AV
... ...  |..|. |.||| ||.||. . |. .| .  .|... .. ... ..||  .
ellefirealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplga

0036282 (Phosphotyrosine protein) phosphatases II 155-303 8.4e-24 79.6 In-house 10-152 (174) alignment
Range on Protein: 155-303
Range on HMM: 10-152/174.0
MHYSRILPNIWLGSCPRQvehvTIKLKHELGITAVMNFQTEWDivQNSSGCNRYPEPmtpdtMIKLYREEGLAYIWMPTPDMSTEGRVQmLPQAVCLLHA
.. |.|.|....|..| .     ... .|||||.| .. .|.    .. .| .|        . . ....|. |...|.||...    . | ..|.... 
ldlsyitprliagqgpla....fwemlkelgittvvmlleeke..lglykcinywpe.....lredlerlgiqylylpwpDhgvpdlsi.llefvkfvee

LLEK--GHIVYVHCNAGVGRSTAAVCGWLQYVMGW-NLRKVQYFLMAKR---PAV
 |..  |. |.|||.|||||. . |. .| ..... .|... ... ..|   | .
alsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgm

0051082 (Phosphotyrosine protein) phosphatases II 155-305 3.5e-22 74.0 In-house 6-137 (151) alignment
Range on Protein: 155-305
Range on HMM: 6-137/151.0
MHYSRILPNIWLGSCPRQvehVTIKLKHELGITAVMNFQTEWDIVqnssgcnrypepmtpdTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHA
 ..|.. ........| .     ..| .||||....|. .|. .                 .. ....|.|. ....| .|... |  ....... .|..
infsyvtgglyrsggpla...dflellkelgiktivnlrseeerg................ycpeylpelgievlhipildwpdpglplsfdavleflel

LLEK-GHIVYVHCNAGVGRSTAAVCGWLQYvMGWNLRKVQYFLMAKRPAVYI
||.| .. |.|||.||.||. . |. .| . .|..| ..  ....||| |..
lldkkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvq

subfamily_DSP3_pd Subfamily DSP3 155-284 2.4e-07 24.5 In-house 9-122 (162) alignment
Range on Protein: 155-284
Range on HMM: 9-122/162.0
MHYSRILPNIWLGSCPRQVEHvtIKLKhELGITAVMNfqtewdivqNSSGcnRYpepMTPDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLH-
 ..  . |....|      ..   ||| .|||| |.|          . |  |.   .. ||  . |.. .. |. ..  |. .    .   .|.  .. 
kevdevypklyvgdeavakdk..skLk.klGithvln.........aaeg..rf...skvdtgaefykdleikylGlevdDvpefdlskyFetaakfide

ALLEKGHIVYVHCNAGVGRSTAAVCGWLQYV
|| .|   |.|||..|| ||.. |  .|  .
alsqkegkvlvhcvvGvsRsatlvlayLmir

0037934 (Phosphotyrosine protein) phosphatases II 156-302 6.2e-16 54.1 In-house 38-222 (243) alignment
Range on Protein: 156-302
Range on HMM: 38-222/243.0
HYSRILPNIWLGSCPRQVEHVT-----IKLKHELGITAVMNFQTEWDIvqNSSGCNRYPE-PMTPDTM------------------------IKLYREEG
 .....|.......| .  .       ... .|||||.. .. ....   .  .| .|   ..| ...                        .. .  ..
nliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvEl..grekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlv

LAYIWMPTPD----MSTEGRVQMLPQAVCLLHA-----LLEKGHIVYVHCNAGVGRSTAAVCGWLQYVM-GWNLRKVQYFLMAKRPA
  | ..| ||     |.|  ...| ..   ...      | .|. |.||| |||||. . .. .| . . |..| ..  .| ..|| 
ihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpg

0048179 (Phosphotyrosine protein) phosphatases II 157-307 3.1e-25 84.0 In-house 4-131 (144) alignment
Range on Protein: 157-307
Range on HMM: 4-131/144.0
YSRILPNIWLGSCPRQVEhvtIKLKHELGITAVMNFQTEWDIVQNSSGcnrypepmtpdtmiklyreeGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALL
.|.|||...|||.|  ..   ..| ..||||.| |...|..                           |. |...|.||...    ..|.... .....|
pseilpglylgslptald...lellkklgittvinlteeyepeflere....................giqylhlpwpDhgvpdllellleflefieeal

EKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDE
|.|. |.|||.|||||... |. .| ...|..| .. ... ..|| ... .
eeggpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrsrrpgavpnp

0048076 (Phosphotyrosine protein) phosphatases II 157-307 3.9e-25 83.6 In-house 4-129 (145) alignment
Range on Protein: 157-307
Range on HMM: 4-129/145.0
YSRILPNIWLGSCPRQVEhvtIKLKHELGITAVMNFqtewdivqnssgcnrypepmtpDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALL
.|.|||...|||.|  ..   ..| ..||||.| |.                       ....|. ..|. |...|.||...    ..|.... .....|
pseilpglylgslptald...lellkdlgittvlnl......................tselellerlgiqylylpwpDhgvpdllellleflefieeal

EKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDE
..|. |.|||.|||||... |. .| . .|..| ..  .. ..|| . . .
keggpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrsqrpgavpnp

0042113 (Phosphotyrosine protein) phosphatases II 157-303 1.2e-18 62.9 In-house 47-225 (245) alignment
Range on Protein: 157-303
Range on HMM: 47-225/245.0
YSRILPNIWLGSCPRQVehvTIK----LKHELGITAVMNFQTEWDivQNSSGCNRYPEPmtPDTM----------------------------IKLYREE
 .|| |.......| .    |..    . .|||||.. .. .|..   .  .| .|  .   ...                             . .  |
gyritpkfiatqgPlpe...tvedfwrmlwelgittivmLteeee..lgrvkcaqywpl..gesltygdftvtllseehlddytvrtlevtnlgddesre

GLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLE--KGHIVYVHCNAGVGRSTAAVCGWLQ-----YVMGWNLRKVQYFLMAKRPAV
.. | ..| ||...   ...| ... ...  |.  ... |.|||.|||||. . .. .|      . .|..| .. ..|  .|| .
vihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpga

0043147 (Phosphotyrosine protein) phosphatases II 158-304 5.2e-20 67.3 In-house 16-144 (172) alignment
Range on Protein: 158-304
Range on HMM: 16-144/172.0
SRILPNIWLGSCP-RQVEHVTIKLKHELGITAVMNFQTEwdivqnssgcnrypepmtpDTMIKLYREEGLAYIWMPTPDMSTEgRVQMLPQAVCLLHA--
..| .... .  | |   .  ... .|||||.. |  ..                    .  .|. ..|. |...| ||...    ..|.... ...   
yyipdrfiatqgplrntladfwrmlkelgithivnltel...................lydpellerlgiqylylpwpDhgvp.llellleflefidell

LLEKGHIVYVHCNAGVGRSTAAVCGWLQYvMGWNLRKVQYFLMAKRPAVY
.|..|. |.||| |||||. . |. .| . .|..| ..  .. .||| . 
alspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgav

PTPc_motif_SM00404 158-303 6.2e-18 60.0 In-house 3-124 (140) alignment
Range on Protein: 158-303
Range on HMM: 3-124/140.0
SRILPNIWLGSCPRQVehvTIKLKHELGITAVMNFQTEWDIVqnssgcnrypepmtpdtmiklYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLE
|||||...|||.....     .|. .||||.|.| ..| ..                      . ..|  ....|  |  ..  .. |....  ...  .
srilphlylgskskaq...npallkklgithvinvteevslt.....................kensgfqilqiplddnekdklskyldkvldfienaek

KGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV
||. |.||| ||| || . .. .| . ....|... .|.  .||..
kggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerRpii

0039614 (Phosphotyrosine protein) phosphatases II 162-303 2.6e-14 48.8 In-house 5-271 (297) alignment
Range on Protein: 162-303
Range on HMM: 5-271/297.0
PNIWLGSCPRQVEHVTIKLKHElGITAVMNFQTEWDIV------------QNSSGCNRYP-EPMTPDTMIKLYREEG----LAYI---------------
.. .|.|.| ....... |..|   .  . ...|.  .            ...  .|||.  .. .....||  |.|    . ||               
rdallesipiplsvldllllle.kansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkf

--------------------------------------------------------------------------------------WMPTPDMSTEGRVQ
                                                                                      ... ||...   ..
IatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppsle

MLPQAVCLLHALLE---KGHIVYVHCNAGVGRSTAAVCGWLQ-----YVMGWNLRKVQYFLMAKRPAV
 | ... |..  |.   ||. |.|||.|||||. . .. .|      .  |... ..  .|  .|| .
llleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpga

DSPc Dual specificity phosphatase, catalytic domain 164-304 3.1e-15 51.2 Pfam-A 1-118 (133) alignment
Range on Protein: 164-304
Range on HMM: 1-118/133.0
IWLGSCPRQVehvtIKLKHELGITAVMNFQTEWDIVqnssgcnrypepmtpdtmiKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVY
..|||....      .|. .||||.|.| ..| .                     ... ..   |...|  |....  .. |..||  .... .||. |.
lylgskstas....lalleklgitlvinvtkevpnn...................naikkseieylripvedetetkiskeleeavefiekaeqkgkkvl

VHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVY
|||.||. || . .. .| . ....|..  .|.  .|... 
VHCqaGisRSatliiaYlmktknlslneAyefvkerrskis

DSPc Dual specificity phosphatase, catalytic domain 164-304 3.1e-15 51.2 In-house 1-118 (133) alignment
Range on Protein: 164-304
Range on HMM: 1-118/133.0
IWLGSCPRQVehvtIKLKHELGITAVMNFQTEWDIVqnssgcnrypepmtpdtmiKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVY
..|||....      .|. .||||.|.| ..| .                     ... ..   |...|  |....  .. |..||  .... .||. |.
lylgskstas....lalleklgitlvinvtkevpnn...................naikkseieylripvedetetkiskeleeavefiekaeqkgkkvl

VHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVY
|||.||. || . .. .| . ....|..  .|.  .|... 
VHCqaGisRSatliiaYlmktknlslneAyefvkerrskis

0049772 (Phosphotyrosine protein) phosphatases II 168-320 4.8e-22 74.5 In-house 155-272 (314) alignment
Range on Protein: 168-320
Range on HMM: 155-272/314.0
ScprqvehvtiklkhelgitavmNFQTEWDIVQNSsgcnrypepmTPDTMIKLYREEGLAYIWMPTPDMSTEgRVQMLPQAVCLLHALlEKGHIVYVHCN
                       |. |..|. .            .  .  .|. ..|. |...|.|| |.    ....... ..... .||. |.|||.
g......................neptaadlellk..........eelydpelferlgikylripvpDgsap.lledfdeflefieea.dkggpvlvHCk

AGVGRST-AAVCGWLQYVMGWNLRKVQYFLMAKRPaVYIDEEALaRAQEDFFQK
||.||.. ..|...| . .|..|...  ....||| ... . .. . .|.. ..
aGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfi.eqleqyefi

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 178-303 2.5e-07 24.3 In-house 26-130 (148) alignment
Range on Protein: 178-303
Range on HMM: 26-130/148.0
IKLKHELGITAVMNFQTEWDIVQNSSgcnrypepmtpdtmiklyreeGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAV
..  ..||.|...| . | | . .                       |. |. ..  |   |   .. ....  ..   ..|. | ||.. || ||.| .
lealkalgvtrivnatkerdnaldqr.....................gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssala

CGWLQYVMGWNLRKVQYFLMAKRPAV
  ||       |..   .   ||. |
llwlidfkrvslkealalvkskrryv

0049260 (Phosphotyrosine protein) phosphatases II 179-307 8.6e-18 59.9 In-house 27-136 (152) alignment
Range on Protein: 179-307
Range on HMM: 27-136/152.0
KLKHELGITAVMNFQTEWDivQNSSGCNRYPepmtpdtmiklyreeglAYIWMPTPDMSTEGRVQMLPQAVCLLHA-LLEKGHIVYVHCNAGVGRSTAAV
.. .|||||.. .  .. .   .  .|..|.                  |...|.||...    |.|.... ...  .|.||. |.||| |||||. . |
rmlkelgittivmltelle..lgklkceqyi.................qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

CGWLQYvMGWNLRKVQYFLMAKRPAVYIDE
. .| . .|..| ..  .. .||| ... .
aaylml.lgvsleeavalvrekRpgavpnp

subfamily_PTPDC1_pd Subfamily PTPDC1 181-305 6.9e-09 30.4 In-house 42-160 (182) alignment
Range on Protein: 181-305
Range on HMM: 42-160/182.0
KHELGITAVMNFQTEWDIVQNSSGCNRYPEPMTPDTmiklYREEGLAYIWMPTPDMSTEGRVQMLpQAVCLLHALLEKGhIVYVHCNAGVGRSTAAVCGW
  | ||.||.|.|.. .  .  .| ..      ..     . |.|...  .. .| ..    ..| . | ...  |..|  | ||| || ||    .. .
fkesgikavinLqekgehasCGagleesGfsYdlea....lmeqgiyvynfgwkDygvasleriL.divkvvafalqeg.kvavhChaGlGrtGvliacy

LQYVMGWNLRKVQYFLMAKRPAVYI
| |.   .  |   .. .|||    
lvyakrltaekaiklvrskrpksiq

PTEN_1 182-311 2.6e-15 51.7 In-house 64-178 (196) alignment
Range on Protein: 182-311
Range on HMM: 64-178/196.0
HELGITAVMNFQTEWDIvqnssgcnrypepMTPDTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALL--EKGHIVYVHCNAGVGRSTAAVCG
.| |||.|.|.  | ..             ....   ......|. |. .| .|  .    ...  .. . ..||  ..|..|.||| ||.|||   |. 
kedgitlvvnlseeeel.............sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa

WLQYVMGWNLRKVQYFLMAKRPAVYIDeealA
.| | .... ..   .. .|||.. .      
yLmykgkltadeAlelvrekRppgapn....s

subfamily_DSP15_pd Subfamily DSP15 186-301 1.7e-07 25.4 In-house 28-120 (151) alignment
Range on Protein: 186-301
Range on HMM: 28-120/151.0
ITAVMNFQTewdivqnssgcnrypepmtpdTMIKLYREegLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVM
|| ... .                         || ..  . |  ..  | .     ... ..| ..|.   |.. |.||| ||| ||.  |  .|  |.
ithilsvhd.....................nakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvt

GWNLRKVQYFLMAKRP
  | |..  .. |.| 
elnwrdalevikaaRs

0040438 (Phosphotyrosine protein) phosphatases II 193-303 1.1e-11 40.1 In-house 34-258 (317) alignment
Range on Protein: 193-303
Range on HMM: 34-258/317.0
QTEWDIVQNSSGCNRYPEPMTPD-----------------------------------------------------------------------------
 ... . ... . ||||  .  |                                                                             
tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwp

------------TMIKLYREEGLAYIWMPTPDM----------------STEGRVQMLPQAVCLLHALLEK----GHIVYVHCNAGVGRSTAAVCGWLQ-
            |... . ..|  . ...  |.                   |  . . . . .|.|. |.    |. | |||.|||||. . .. .|  
lgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylml

----YVMGWNLRKVQYFLMAKRPAV
    . .|... .. ..| ..|| .
eqlekeggvdveeavkelreqRpga

0040439 (Phosphotyrosine protein) phosphatases II 200-304 1.6e-12 43.0 In-house 9-229 (249) alignment
Range on Protein: 200-304
Range on HMM: 9-229/249.0
QNSSGCNRYPEPMTPD-TMI--------------------------------------------------------------------------------
...  .||||  . .| ...                                                                                
penkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsley

------------------------KLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLE------KGHIVYVHCNAGVGRSTAAVCGWLQ-----Y
                        .||  | . . ... .|.   |  . ..... ...|...      ||. |.|||.|||||. . .. .|      .
gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlek

VMGWNLRKVQYFLMAKRPAVY
  |..|  .  .|  .|| . 
elgvdleeavkllrsqRpgav

subfamily_DSP6_pd Subfamily DSP6 215-291 8.3e-08 25.9 In-house 49-125 (158) alignment
Range on Protein: 215-291
Range on HMM: 49-125/158.0
DTMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRK
.   |   .. | |  .|  |  ..   ...|.|. ..    .|   | ||| ||. || . .  .|   .   | .
nlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslnd

subfamily_STYX_pd Subfamily STYX 216-306 2e-09 30.7 In-house 53-143 (166) alignment
Range on Protein: 216-306
Range on HMM: 53-143/166.0
TMIKLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYID
..||   .. . |. .   | ..|  .. ||.   ..   |.||  | || |||. ||.| | ...   .| . |.   ..  .|  .  .
nlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpn

0045098 (Phosphotyrosine protein) phosphatases II 217-302 1.7e-13 46.1 In-house 147-252 (278) alignment
Range on Protein: 217-302
Range on HMM: 147-252/278.0
MIKLYREEGLAYIWM-PTPDMSTEGRV--QMLPQAVCLLHALLE--------------KGHIVYVHCNAGVGRSTAAVCGWLQYVM---GWNLRKVQYFL
. . . . |. .... | ||...      . . ...  ... |.              .|. |.|||.|||||. . |. .| . .   |..| ..  .|
eredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkel

MAKRPA
  .|| 
rsqRpg

0038934 (Phosphotyrosine protein) phosphatases II 219-306 3.3e-15 51.7 In-house 73-162 (194) alignment
Range on Protein: 219-306
Range on HMM: 73-162/194.0
KLYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEK--GHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYID
... . |. |. .|.||  |    ..| . . |..  |..  |..|.||| ||.||.   |. .| |..|.....  ...  ||| ... 
eefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipn

subfamily_DSP10_pd Subfamily DSP10 220-303 1.2e-09 32.3 In-house 53-136 (159) alignment
Range on Protein: 220-303
Range on HMM: 53-136/159.0
LYREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV
 ..||.| |  .|  | |..   |   .|.  ..   .||. | |||.||. ||.. | ..| . .. .|..   |   |||..
efeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpii

subfamily_Slingshot_pd Subfamily Slingshot 221-303 7.7e-06 19.4 In-house 58-140 (169) alignment
Range on Protein: 221-303
Range on HMM: 58-140/169.0
YREEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV
. .| ..|. .   | ...  ..   ..   ...  .||  | |||  || ||...|  .     |..| .   ..  .|  .
ffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvi

0043336 (Phosphotyrosine protein) phosphatases II 223-303 2.7e-10 35.7 In-house 173-259 (278) alignment
Range on Protein: 223-303
Range on HMM: 173-259/278.0
EEGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLE-KGHIVYVHCNAGVGRSTAAVCGWLQ-----YVMGWNLRKVQYFLMAKRPAV
 ... | ... ||...   ...| . .  ..  || ... |.|||.|||||. . .. .|      .  |..| ..  .|  .||  
rtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpga

subfamily_DSP14_pd Subfamily DSP14 224-303 9.3e-07 22.9 In-house 48-127 (157) alignment
Range on Protein: 224-303
Range on HMM: 48-127/157.0
EGLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV
...... .|  |....  .. . ...  .... .||. . ||| ||| || . .  .|      .||.    . ..|| .
kdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpii

subfamily_DSP1_pd Subfamily DSP1 225-302 3e-07 24.7 In-house 61-138 (163) alignment
Range on Protein: 225-302
Range on HMM: 61-138/163.0
GLAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPA
 . | ...  | ...   ... ...  ...  .|.  |..||.||. ||.. .  .|     ..| .   |   .|. 
lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsi

subfamily_DSP19_pd Subfamily DSP19 226-303 2.7e-09 31.6 In-house 56-133 (152) alignment
Range on Protein: 226-303
Range on HMM: 56-133/152.0
LAYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV
. |  ..  | . .  ...|..|.  ..  ..|  .|.||||||| ||.. | ..|      .|..    . ..||..
ftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpci

0047943 (Phosphotyrosine protein) phosphatases II 227-306 2.5e-09 32.5 In-house 170-257 (273) alignment
Range on Protein: 227-306
Range on HMM: 170-257/273.0
AYIWMPTPDMSTEGRVQMLPQAVCLLHALLE---KGHIVYVHCNAGVGRSTAAVCGWLQ-----YVMGWNLRKVQYFLMAKRPAVYID
 . ... ||...   ...| . . |..  ||   ... |.|||.|||||. . .. .|      .  |... .. ..|  .|| . . 
hfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqt

0051299 (Phosphotyrosine protein) phosphatases II 227-305 6e-08 27.9 In-house 186-270 (288) alignment
Range on Protein: 227-305
Range on HMM: 186-270/288.0
AYIWMPTPDMSTEGRVQMLPQAVCLLHAL-LEKGHIVYVHCNAGVGRSTAAVCGWLQ-----YVMGWNLRKVQYFLMAKRPAVYI
 . ..  ||...   ...| . . |..     .|. |.|||.|||||. . .. .|      .  |... ..  .|  .|| . .
hfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvq

subfamily_MKPLT_pd Subfamily MKPLT 227-303 2.4e-07 24.4 In-house 67-143 (164) alignment
Range on Protein: 227-303
Range on HMM: 67-143/164.0
AYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV
 |  . . | |.|   . | .|  .|   .. |  |.|||. |. ||...   .|    || |..   .|  .|  |
eYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsiv

subfamily_MKPLV_pd Subfamily MKPLV 227-303 2.4e-07 24.4 In-house 67-143 (164) alignment
Range on Protein: 227-303
Range on HMM: 67-143/164.0
AYIWMPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAV
 |  . . | |.|   . | .|  .|   .. |  |.|||. |. ||...   .|    || |..   .|  .|  |
eYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsiv

0045450 (Phosphotyrosine protein) phosphatases II 228-304 1.7e-11 39.9 In-house 200-287 (307) alignment
Range on Protein: 228-304
Range on HMM: 200-287/307.0
YIWMPTPDMSTEGRVQMLPQAVCLLHALLE---KGHIVYVHCNAGVGRSTAAVCGWLQYVMG--------WNLRKVQYFLMAKRPAVY
...   ||...   ...| . . .... ||   ||. |.|||.|||||. . .. .| ....        ..|...  .| ..|| . 
fhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgav

0050432 (Phosphotyrosine protein) phosphatases II 228-307 2.9e-09 32.1 In-house 202-285 (308) alignment
Range on Protein: 228-307
Range on HMM: 202-285/308.0
YIWMPTPDMSTEGRVQMLPQAVCLLHALLeKGHIVYVHCNAGVGRSTAAVCGWLQ-----YVMGWNLRKVQYFLMAKRPAVYIDE
. ..  ||...   ...| . . |..  | .|. ..|||.|||||. . .. .|      .  |... .. ..|  .|| . ...
fhytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp

0046845 (Phosphotyrosine protein) phosphatases II 228-305 1.8e-08 29.6 In-house 170-258 (284) alignment
Range on Protein: 228-305
Range on HMM: 170-258/284.0
YIWMPTPDMSTEGRVQMLPQAVCLLHALLEK---GHIVYVHCNAGVGRSTAAVCGWLQYVM--------GWNLRKVQYFLMAKRPAVYI
. ... ||...   .. | . . |.. |||.   |. . ||| |||||. . .. .| . .        |... .. ..|  .||    
fhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvq

subfamily_DSP12_pd Subfamily DSP12 231-308 1.4e-10 35.8 In-house 54-131 (155) alignment
Range on Protein: 231-308
Range on HMM: 54-131/155.0
MPTPDMSTEGRVQMLPQAVCLLHALLEKGHIVYVHCNAGVGRSTAAVCGWLQYVMGWNLRKVQYFLMAKRPAVYIDEE
..  |. .|  .. |..||  ..  ||..  |.|||.||| || ..|  .| .  ...| |   .. .|.| ..  | 
iqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpeiepNeg

0036941 (Phosphotyrosine protein) phosphatases II 231-305 2.9e-08 28.8 In-house 176-261 (297) alignment
Range on Protein: 231-305
Range on HMM: 176-261/297.0
MPTPDMSTEGRVQMLPQAVCLLHALLE---KGHIVYVHCNAGVGRSTAAVCGWLQ--------YVMGWNLRKVQYFLMAKRPAVYI
.  ||...   .. | . . |..  |.   .|. |.|||.|||||| . .. .|         .  |... ..  .|. .|| .  
tgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavq