Gene PTP4A1 in Homo sapiens

Synonym: HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1, RP5-1148A21.2, PTP4A1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PRL
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP035_AA protein Get Run
HsapP035_AA_6-159 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045450 (Phosphotyrosine protein) phosphatases II 4-152 2.2e-32 108.4 In-house 94-299 (307) alignment
Range on Protein: 4-152
Range on HMM: 94-299/307.0
MNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTL------------------------------------------VEKE
......... .....|..| .|.. |...|.. |...|||.||...| ....                                             ..|
vpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtge

GIHVLDWPF----DDGAPPSNQIVDDWLSLVKIKFREE-PGCCIAVHCVAGLGRAPVLVALALIEGG---------MKYEDAVQFIRQKRRGAF-NSKQL
...|  ...    |.|.||| ... |.. .|.  ..|  .|....||| ||.||.....|. |.  .         . ...||...|..| ||. |  |.
srtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy

LYLEKY
 .| ..
rflyea

0043147 (Phosphotyrosine protein) phosphatases II 8-167 3.1e-44 146.1 In-house 11-170 (172) alignment
Range on Protein: 8-167
Range on HMM: 11-170/172.0
APVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAG
 .....|. .||..|. |.. ||..|.. ||..|.|.||...| .||..|.|..||..| .|..|. .|. ......|.... .. ..||....|||.||
syldlyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaG

LGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHR
.||...|||. |.. |...|.||...|.||.||. ... ... .|  |..|..|||....
vgRtgtlvaaylmllglsleeavalvrekRpgavqnpsqyrflyyfeklllllkdslaek

0036282 (Phosphotyrosine protein) phosphatases II 8-153 6.3e-32 106.0 In-house 8-166 (174) alignment
Range on Protein: 8-153
Range on HMM: 8-166/174.0
APVEVTYKNMRFLITHNPTNatlnkFIEELKKYGVTTIVRVCEATYDT------------TLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREE
 |. ..| . |....  |..     |.|.||..|.||.|...|  ..             .  |..||..|..|..|. .|. .|.......|.  . | 
spldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsed

PGCCIAVHCVAGLGRAPVLVALALIEGGM--KYEDAVQFIRQKR----RGAFNSKQLLYLEKYR
||....||| ||.||...|||. |.. |.  ...||....|..|    ..  .  |. .| ...
pggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe

subfamily_PRL_pd Subfamily PRL 9-157 1.8e-80 262.3 In-house 2-150 (151) alignment
Range on Protein: 9-157
Range on HMM: 2-150/151.0
PVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGL
.||..||.||||||..||.|||.||||||||..|.|.|||||.||||. .|||||.|||..|||||.|....|..||.|.| ||.|||....||||||||
eveieykkmrflitdrPtdatlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGl

GRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMR
||||||||||||| ||||||||.|||.|||||.||||| .||||..|..
GraPvlvalalieaGmkyedavefirekrrgainskqlkflekykakkk

0040439 (Phosphotyrosine protein) phosphatases II 10-152 2e-36 121.3 In-house 47-241 (249) alignment
Range on Protein: 10-152
Range on HMM: 47-241/249.0
VEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEAT---------------------------------------------YDTTLVEKEGIH
....| ..||..|  |.. |...|.. |...|.|.||.... .                                             || . ..  .|.
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

VLDWPfDDGAPPSNQIVDDWLSLVKIKFREE-PGCCIAVHCVAGLGRAPVLVALALI------EGGMKYEDAVQFIRQKRRGAF-NSKQLLYLEKY
..||| |.|.||| ....|.. .|.  ..|  .|....||| ||.||.....|. |.      |.|. .|.||...|..|.||. |  |. .| ..
ytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea

0042113 (Phosphotyrosine protein) phosphatases II 10-152 1.5e-31 105.1 In-house 45-238 (245) alignment
Range on Protein: 10-152
Range on HMM: 45-238/245.0
VEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEAT---------------------------------------------YDTTLVEKEGIH
| . . . .|..|  |.. |...|.. |...|.||||...| .                                             .|    |   .|
vdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

VLDWPfDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI------EGGMKYEDAVQFIRQKRRGAF-NSKQLLYLEKY
 |.|| |.|.|.. ....|.|..|.   .| ..  ..||| ||.||. ...|. |.      |.|.  |.||...|..|.||. .  |. .| ..
ylpwp.dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea

0040438 (Phosphotyrosine protein) phosphatases II 10-152 3.9e-30 100.6 In-house 79-271 (317) alignment
Range on Protein: 10-152
Range on HMM: 79-271/317.0
VEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEAT---------------------------------------------YDTTLVEKEGIH
|.. .....|..|  |.. |...|.. ....|||.||...| .                                             .| . ..   .|
vdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfh

VLDWPfDDGAPPSNQIVDDWLSLVKIKFReEPGCCIAVHCVAGLGRAPVLVALALI------EGGMKYEDAVQFIRQKRRGAF-NSKQLLYLEKY
 ..|| |.|.||| ... |.|..|. ... .||....|||.||.||. ...|. |.      |||. .|.||...|..|.||. .  |. .| ..
ytgWp.dhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda

0047943 (Phosphotyrosine protein) phosphatases II 10-146 2.1e-28 95.0 In-house 70-260 (273) alignment
Range on Protein: 10-146
Range on HMM: 70-260/273.0
VEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTT----------------LVEKEG-------------------------------
|.. .....|..| .|.. |...|.  .....|..||...| ...                   ..|                                 
vdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvt

-IHVLDWPfDDGAPPSNQIVDDWLSLVKIKFREE-PGCCIAVHCVAGLGRAPVLVALALI------EGGMKYEDAVQFIRQKRRGAFNSKQL
 .|...|| |.|.||| ... ... ||. ....   .  ..|||.||.||. ...|| |.      |||. ...||...|..| |.. . . 
hfhytgwp.dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeq

0051299 (Phosphotyrosine protein) phosphatases II 10-145 1.1e-27 92.7 In-house 85-273 (288) alignment
Range on Protein: 10-145
Range on HMM: 85-273/288.0
VEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEAT-------------------------------------------------YDTTLVEK
... .....|..|  |.. |...|   . ...|..||.... .                                                 .| .  . 
idgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtv

EGIHVLDWPfDDGAPPSNQIVDDWLSLVKIKFReEPGCCIAVHCVAGLGRAPVLVALALI------EGGMKYEDAVQFIRQKRRGAFNSKQ
  .|...|| |.|.|.| . . |.| ||. ...  .|....||| ||.||. ...|| |.      |||. ...||...|..| |.... .
thfhytnwp.dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe

0036941 (Phosphotyrosine protein) phosphatases II 10-148 3.7e-25 84.3 In-house 71-276 (297) alignment
Range on Protein: 10-148
Range on HMM: 71-276/297.0
VEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVC--------------------------------------EATYDTTLVEKEG---------
|.. . ...|..|. |.. |...|   . ...||.|| ..                                      ...| .. .| .          
vdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtv

--IHVLDWPfDDGAPPSNQIVDDWLSLVKIKFREE-PGCCIAVHCVAGLGRAPVLVALAL---------IEGGMKYEDAVQFIRQKRRGAFNSKQ-----
  .|...|| |.|.|.| ... |.. ||. . ..  .|  . |||.||.||. ...|. |         .|||. . .||...|..| ||. . .     
thfhytgwp.dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl

----LLY
    | .
yeallel

0049260 (Phosphotyrosine protein) phosphatases II 11-152 7.2e-40 131.5 In-house 3-144 (152) alignment
Range on Protein: 11-152
Range on HMM: 3-144/152.0
EVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGR
.. .....|..|. |.. ||..|.. ||..|.||||...| .... | ....|..| .|..|. .|.. .. ..| |.  |.....|....|||.||.||
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgR

APVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKY
...|||. |.. |...|.||...|.|| ||. ... |.. ..
tgtlvaaylmllgvsleeavalvrekRpgavpnpgqlrflye

0043336 (Phosphotyrosine protein) phosphatases II 11-149 1.9e-30 101.7 In-house 82-269 (278) alignment
Range on Protein: 11-149
Range on HMM: 82-269/278.0
EVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEAT--------------------------------------------YDTTLVEKEGIHVL
..  ....|..|  |.. |...|.. ....||||||...| .                                            .|    .  ..| |
dgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhyl

DWPfDDGAPPSNQIVDDWLSLVKIKFReEPGCCIAVHCVAGLGRAPVLVALALI------EGGMKYEDAVQFIRQKRRGAF-NSKQLLYL
.|| |.|.|.| ... |.|  |. ...  .. ...|||.||.||. ...|| |.      |||. .|.||...|..| ||. .  |. .|
gwp.dhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfl

0050432 (Phosphotyrosine protein) phosphatases II 11-146 2.9e-28 94.5 In-house 100-287 (308) alignment
Range on Protein: 11-146
Range on HMM: 100-287/308.0
EVT--YKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTT------LVEKEG----------------------------------------
 .   .....|..|  |.. |...|.  . ...|..||.... ...          ...|                                        
dgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtv

--IHVLDWPfDDGAPPSNQIVDDWLSLVKIKFreePGCCIAVHCVAGLGRAPVLVALALI------EGGMKYEDAVQFIRQKRRGAFNSKQL
  .| ..|| |.|.||| .|. |.| ||. ..   ||. |.||| ||.||. ...|| |.      |||. ...||...|..| |...... 
thfhytnWp.dhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeq

0046845 (Phosphotyrosine protein) phosphatases II 12-145 9.6e-26 86.2 In-house 72-261 (284) alignment
Range on Protein: 12-145
Range on HMM: 72-261/284.0
VTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATY-----------------------------------------------DTTLVEKEGIH
.||....|..|  |.. |...|   . ...|..|| ..| .                                                .   ..   .|
ltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfh

VLDWPfDDGAPPSNQIVDDWLSLVKIKFRE-EPGCCIAVHCVAGLGRAPVLVALALIEG---------GMKYEDAVQFIRQKRRGAFNSKQ
...|| |.|.||| ... ..| ||.  ... ..|. |.||| ||.||. ...|| |.           |. ...||...|..| |.... .
ytswp.dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle

0041856 (Phosphotyrosine protein) phosphatases II 13-161 1.3e-33 111.5 In-house 30-174 (182) alignment
Range on Protein: 13-161
Range on HMM: 30-174/182.0
TYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSnqiVDDWLSLVKIKFReePGCCIAVHCVAGLGRAP
 ....||..|. |.. |...|.. ||..|.||||...|  |. .|.|..||..|..|..|. .|.   .|..|.....  .  .|....||| ||.||..
slpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd...ldelldfieevle..eggpvlVHCsaGvgRtg

VLVALALIE-GGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFK
.|||. |..  |. .|.||...|..| |.. . . .... .   ..|..|
tlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllk

0039614 (Phosphotyrosine protein) phosphatases II 13-160 1.4e-32 108.8 In-house 96-292 (297) alignment
Range on Protein: 13-160
Range on HMM: 96-292/297.0
TYK-NMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYD----------------------TTLVEKEG-------------------IHVLDWPf
 .. ...|..|  |.. |...|.. ....|||.||.... ...                      ..  ...|                   .....|| 
ydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp.

DDGAPPSNQIVDDWLSLVKIKFREE-PGCCIAVHCVAGLGRAPVLVALALI------EGGMKYEDAVQFIRQKRRGAF-NSKQLLYLEKYRPKMRLRF
|.|.||| ......| ||.  ..|  .|....|||.||.||. ...|. |.      |||. ...||...|..|.||. .  |. .| ..  ....|.
dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

0045098 (Phosphotyrosine protein) phosphatases II 14-161 3.2e-34 114.0 In-house 62-276 (278) alignment
Range on Protein: 14-161
Range on HMM: 62-276/278.0
YkNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDT----------------------------------------------TLVEKEGIHVLD
| ...|..|  |.. |...|.. |...|.|.||...| ....                                              .  |. |...|.
y.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlh

W-PFDDGAPPSNQIVDDWLSLVKIKFR---------------EEPGCCIAVHCVAGLGRAPVLVALALIEG----GMKYEDAVQFIRQKRRG-AF-NSKQ
. |..|. .||. |.. .|.|..   .               ...|....||| ||.||. .|||. |.      |. ...||...|..|.| |. |  |
ylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleq

LLYLEKYRPKMRLRFK
. .|...  ...||.|
yrflyefllelllrgk

0037934 (Phosphotyrosine protein) phosphatases II 15-152 8.7e-27 89.6 In-house 44-237 (243) alignment
Range on Protein: 15-152
Range on HMM: 44-237/243.0
KnmRFLITHNPTNATLNK----FIEELKKYGVTTIVRVCEAT------------------------------------------YDTTLVEKEGIHVLDW
.  |. .|  |.. |..     |.. |...|.|.|| ..| .                                          .|.. .....||.. .
p..rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhyl

PFDDGAPPS-NQIVDDWLSLVKIKFRE-------EPGCCIAVHCVAGLGRAPVLVALALIEG--GMKYEDAVQFIRQKRRG-AF-NSKQLLYLEKY
|. |. .|.  ... |.|. |.   .|        .|  ..|||.||.||. .|.|. |.    |. .|.||...|..| | |. .  |. .| ..
pwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea

0049772 (Phosphotyrosine protein) phosphatases II 17-153 1.2e-24 83.1 In-house 84-274 (314) alignment
Range on Protein: 17-153
Range on HMM: 84-274/314.0
MRFLITHNPTNATLNKF--------------------------------------------------------------IEELKkygvttivrvcEATYD
..|..| .|.. |.. |                                                              .|.||           | .||
lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk...........eelyd

TTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKfreEPGCCIAVHCVAGLGRAP--VLVALALIEGGMKYEDAVQFIRQKRR-----GAFNSKQLl
  |.|..||..|..|..|| .|. ...|..| ...     ..| ...||| || ||..  |..|. ..  |. .|.|....|.||      |.... .. 
pelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnpgfieqleq.

YLEKYR
|.....
yefile

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 17-125 6.6e-06 19.8 In-house 88-197 (392) alignment
Range on Protein: 17-125
Range on HMM: 88-197/392.0
MRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATY-DTT--LVEKEGIHVLDWPfDDGAPPSNQIVDDWLSLVKIKFREEPgCCIAVHCVAGLGRAPV
  .. .  |  |.|. | . . .  ||||. | .    |           |. .|| |.. |     .  ..  ||..| .     . .|| ||.||. |
kayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgddartvaqfhftewP.dkdvpkhtssllkfikevkadfGqyt.hpliihcsagvgrtgv

LVALALIEGGMK
....  .    |
visidsvvahak

0038934 (Phosphotyrosine protein) phosphatases II 18-148 1.1e-39 131.4 In-house 19-168 (194) alignment
Range on Protein: 18-148
Range on HMM: 19-168/194.0
RFLITHNPTNATLNKFIEELKKYGVTTIVRVC----------------EATYDTTLVEKEGIHVLDWPFDD-GAPPSNQIVDDWLSLVKIKFREEPGCCI
||.... |.. .|.|.||||........||..                | .||....|| ||..|..|| | |..||..|....|.||. ...| ||...
rfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvv

AVHCVAGLGRAPVLVALALIE-GGMKYEDAVQFIRQKRRGAFNSKQL-LY
||||.|||||...||| .||.  ||..|.|....|.||.||... .   .
aVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdylea

0046846 (Phosphotyrosine protein) phosphatases II 18-155 2.6e-33 110.6 In-house 24-171 (176) alignment
Range on Protein: 18-155
Range on HMM: 24-171/176.0
RFLITHNPTNATLNKFIEELKKYGVTTIVRVCEA--------TYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEpgCCIAVHCVAGLG
|...|. |.. || .|.|.||..|.|..|...|         ...  ..||.||..| .|..|. .|. ......| ...   .|    ...|||.||.|
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsaGig

RAPVLVALALIEG--GMKYEDAVQFIRQKRR-GAF-NSKQLLYLEKYRPK
|...|||. |.|   |...|.|....|..|. ||. . .|. .|...  .
RtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell

0051429 (Phosphotyrosine protein) phosphatases II 18-152 1.9e-18 62.6 In-house 23-220 (272) alignment
Range on Protein: 18-152
Range on HMM: 23-220/272.0
RFLITHNPTNATLNKFIEElKKYGVTTIVRVCEAT---YDTTLVEKEGIHVLDWPFDDGAPPSNQIV---------------------------------
|.. . .|...| . |    |..|..||| ... .   .. .  . .||..| .|. | ..|.  .                                  
rlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsageare

----------------DDWLSLVKIKFReepGCCIAVHCVAGLGRAPVLVALALIEGGMK--------------YEDAVQFIRQKRRGAF-NSKQLLYLE
                .  |.|...  .   |  . ||| || .|  ..||| |.  |.               .|.||. .|..|.||. .  |.|.| 
vmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylfly

KY
..
ea

0051082 (Phosphotyrosine protein) phosphatases II 19-150 2.4e-26 87.6 In-house 15-145 (151) alignment
Range on Protein: 19-150
Range on HMM: 15-145/151.0
FLITHNPTNatlnKFIEELKKYGVTTIVRVCEAT---YDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLV
....  |..     |.|.||..|..||| ... .   |.. .....||.||..|..|  .|. ..  |..  .  .... .. ...||| ||.||  .||
lyrsggpla....dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlv

ALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLE
|| |.  |. .|.|....|.|| |.....|  ...
alylmllgvsleealeeyrlkrpgvvqpnqqflfq

subfamily_STYX_pd Subfamily STYX 25-138 3e-06 20.4 In-house 23-138 (166) alignment
Range on Protein: 25-138
Range on HMM: 23-138/166.0
PTNATLNKFIEELKKYGVTTIVRVCEAtYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKI--KFREEPGCCIAVHCVAGLGRAPVLVALALIEG
|  |...  .| ||| |.| || . ..  ...|.  .  . . .   | |  . . .  .|  ||       . |  . ||  ||. |.  ||   ..| 
pysaamksklevlkkhgithivcirqn.ieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimet

-GMKYEDAVQFIRQKRR
 |.|| .| ......| 
yglkyreafayvqerrf

0044763 (Phosphotyrosine protein) phosphatases II 26-156 8.2e-31 102.4 In-house 37-170 (178) alignment
Range on Protein: 26-156
Range on HMM: 37-170/178.0
TnatlNKFIEELKKYGVTTIVRVCEATY------DTTLVEKEGIHVLDWPFDDGAPPS-NQIVDDWLSLVKIKFReEPGCCIAVHCVAGLGRAPVLVALA
.     ...| ||..|.|.||...| ..      |   .|..||..| .|..|. .|.  ....... ...     |.|....||| ||.||...|||. 
p....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaay

LI-EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKM
|. . |. .|.|....|..|..  |  || .|... ...
lmkklglsleeaielvrerRpivpnpgqlrqLyefelrl

PTEN_1 27-155 4e-22 74.0 In-house 52-190 (196) alignment
Range on Protein: 27-155
Range on HMM: 52-190/196.0
NATLN-KFIEELKKYGVTTIVRVCE------ATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEP-GCCIAVHCVAGLGRAPVLVALA
..... .. ..||. |.|..|...|      ..|| .. .|.|. .|. |..|  .|| . . |..  ..   .. | | ...||| |||||  ..||  
slkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaay

LIEGG-MKYEDAVQFIRQKR-RGAFNSKQLLYLEKYRPK
|.. | . ...|....|.|| .||.|| ..  |..|  .
LmykgkltadeAlelvrekRppgapnspsqerlleyfae

subfamily_PTEN_pd Subfamily PTEN 29-138 1.4e-10 36.4 In-house 49-157 (184) alignment
Range on Protein: 29-138
Range on HMM: 49-157/184.0
TLNKFIEELKkYGVTTIVRV-CEATYDTTLVekeGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMK--
 . ||.|. .  .   |  .  | .||.. .     .|  .||||  ||. ..... .. ..  . |..   ..||| || ||. ||..  |.. ..   
dvvkflekkh.kdhykiynlrserkydskkf...dgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllek

YEDAVQFIRQKRR
 |.|...  ..| 
aeealelfaeaRt

subfamily_CDKN3_pd Subfamily CDKN3 30-156 1.4e-09 31.8 In-house 59-195 (202) alignment
Range on Protein: 30-156
Range on HMM: 59-195/202.0
LNKFIEELKKYGVTTIVRVCEA----TYDT----TLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGccIAVHCVAGLGRAPVLVAL--AL
..| |||||  ||  .  .|       |       | .. |. |  .|. ||  |.     . |  ..| ...  .    |||  ||||. ...|    .
vekdieelksqgvedvfvlctrgelskyrvrrlldlyqqaglivhhypiadglvpdiasclkileelrinlkayrk..tlvhcygglgrsslviacllly

IEGGMKYEDAVQFIRQKRR-GAF-NSKQLLYLEKYRPKM
..  ....||.. .|. .  .|    ||  ||...| |.
lddtiepkdaidklrdlkgsraiqtvkqynylsefrdkl

subfamily_CDC14_pd Subfamily CDC14 31-155 8e-21 69.2 In-house 202-322 (328) alignment
Range on Protein: 31-155
Range on HMM: 202-322/328.0
NKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKfreepGCCIAVHCVAGLGRAPVLVALALIE-GGMKYEDA
.|..|  .|..|||.||. .  || .  ...|..  |  | ||. ||..||  .|....          ||||| |||||.  |.|  |..  ..  ..|
eklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrftaaea

VQFIRQKRRGAFNSKQLLYLEKYRPK
. ..|  | |   ..|  .||. . .
iawlricrPGsvigpqqkfleekqaa

subfamily_DSP15_pd Subfamily DSP15 32-140 7.6e-08 26.6 In-house 18-122 (151) alignment
Range on Protein: 32-140
Range on HMM: 18-122/151.0
KFIEELKKYGVTTIVRVCEatyD-TTLVEKegIHVLDWPFDDGAP-PSNQIVDDWLSLVKiKFREEPGCCiAVHCVAGLGRAPVLVALALIE-GGMKYED
|  | ||.  .|.|. | .   .   |...  |. .  . .| .    ......  ...  | | . . .  |||.||. |.  ||.. |.    ....|
kdeelLkeknithilsvhd...nakkllkd..ieYkciaasDtpsaklskffkesvefih.kcRlkeenv.lvhClaGvsRsvtlvvaYlmtvtelnwrd

AVQFIRQKRRGA
|...|...|  |
alevikaaRsva

subfamily_DSP6_pd Subfamily DSP6 32-138 2.5e-06 21.1 In-house 30-135 (158) alignment
Range on Protein: 32-138
Range on HMM: 30-135/158.0
KFIEELKKYGVTTIVRVCEAtYDTTLVEKEGIHVLDWPFDDGAPPS-NQIVDDWLSLVKIKfrEEPGCCIAVHCVAGLGRA-PVLVALALIEGGMKYEDA
. .| |||...  .. | .   . .  |.. .. |  | .| .     . . . ....      .  . . ||| ||. |.  | .|  . .  .  .||
snlevlkklkikyvlnvtsn.lpnkfeesgelkylqipiedhlsqnlakffPeaiefidea..rskkskvlvhClaGisrsvtvtlaylmkklalslnda

VQFIRQKRR
 ....... 
ydlvkkrks

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 32-120 2.7e-06 21.3 In-house 162-242 (305) alignment
Range on Protein: 32-120
Range on HMM: 162-242/305.0
KFIEELKkYGVTTIVRVCEATYDTTLvEKEGIHVLDWPfDDGAPPSNQIVDDWLslvkIKFREEPGcCIAVHCVAGLGRAPVLVALALI
|| .. |   ||  | | | .  ...      |  ||| | | |.... . . |    .| |   |  |.||| ||.||.  .| |  |
kfrkdak.akvtetvlviegpgekar.kvthyhwidwp.drgvpaadlailell....ekarpskg.pivvhcsagigrtgsvvmleyi

0048179 (Phosphotyrosine protein) phosphatases II 34-154 2.6e-25 84.2 In-house 22-142 (144) alignment
Range on Protein: 34-154
Range on HMM: 22-142/144.0
IEELKKYGVTTIVRVCEaTYDTTLVEKEGIHVLDWPFDDGAPPSN-QIVDDWLSLVKIKFReePGCCIAVHCVAGLGRAPVLVALALI-EGGMKYEDAVQ
.|.|||.|.||.....| .|. . .|.|||..| .|..|  .|.  ......| ...   .  .|....||| ||.||...|||. |. . |. .|.|..
lellkklgittvinlte.eyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklglsleeala

FIRQKRRGAF-NSKQLLYLEKYRP
..|..| ||. |  || .|..|..
lvrsrrpgavpnpgqlrfLleyek

0048076 (Phosphotyrosine protein) phosphatases II 34-154 9.9e-25 82.3 In-house 22-140 (145) alignment
Range on Protein: 34-154
Range on HMM: 22-140/145.0
IEELKKYGVTTIVRVceaTYDTTLVEKEGIHVLDWPFDDGAPPSN-QIVDDWLSLVKiKFREEPgCCIAVHCVAGLGRAPVLVAL-ALIEGGMKYEDAVQ
.|.||..|.||....   |....|.|..||..| .|..|  .|.  ......| ... ....|. ....||| ||.||...|||.  ... |. .|.|..
lellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefie.ealkeg.gpvlVHCsaGvgRtgtlvaaylmlllgvsleeale

FIRQKRRGAF-NSKQLLYLEKYRP
..|..|.||. |  || .|...  
lvrsqrpgavpnpgqlrflyefel

DSPc Dual specificity phosphatase, catalytic domain 34-142 1.9e-11 39.0 Pfam-A 11-118 (133) alignment
Range on Protein: 34-142
Range on HMM: 11-118/133.0
IEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDgaPPSNQIVDDWLSLVK-IKFREEPGCCIAVHCVAGLGRAPVLVALALI-EGGMKYEDAVQ
 . |.|.|.| .. | . .  . . .|. |. |. | .|    ...|...  ..|. |.  |. |. ..||| ||. | . |..  |. . ......|..
lalleklgitlvinvtkevpnnnaikkseieylripved..etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAye

FIRQKRrGAFN
|....| ....
fvkerr.skis

DSPc Dual specificity phosphatase, catalytic domain 34-142 1.9e-11 39.0 In-house 11-118 (133) alignment
Range on Protein: 34-142
Range on HMM: 11-118/133.0
IEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDgaPPSNQIVDDWLSLVK-IKFREEPGCCIAVHCVAGLGRAPVLVALALI-EGGMKYEDAVQ
 . |.|.|.| .. | . .  . . .|. |. |. | .|    ...|...  ..|. |.  |. |. ..||| ||. | . |..  |. . ......|..
lalleklgitlvinvtkevpnnnaikkseieylripved..etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAye

FIRQKRrGAFN
|....| ....
fvkerr.skis

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 34-134 2.7e-06 21.9 In-house 162-264 (319) alignment
Range on Protein: 34-134
Range on HMM: 162-264/319.0
IEELKKYGVTTIvRVCEATYDTTLVEKEGIHVLDWPfDDGAPPSNQIVDDWLSL-VKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQ-
.|| ..| |  | .. | .  .   .    | | || | | | .   .   .    ... .|.    | ||| || ||. | ..|  .   || |. |. 
veetaeyvvrdi.elsedgkekdirkitqfhflGwp.dvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdv

--FIR
  |.|
ynfvr

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 34-134 3.4e-06 21.8 In-house 126-228 (284) alignment
Range on Protein: 34-134
Range on HMM: 126-228/284.0
IEELKKYGVTTIvRVCEATYDTTLVEKEGIHVLDWPfDDGAPPSNQIVDDWLSL-VKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQ-
.|| ..| |  | .. | .  .   .    | | || | | | ..  .   .    ... .|.    | ||| || ||. | ..|  .   || |. |. 
veeseeyvvrdi.elsedgkekdirkirqfhflgwp.dvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdv

--FIR
  |.|
ynfvr

subfamily_Slingshot_pd Subfamily Slingshot 34-139 5.1e-06 20.0 In-house 37-139 (169) alignment
Range on Protein: 34-139
Range on HMM: 37-139/169.0
IEELKKYGVTTIVRVCEAT--YDTTLVEKEGIHVLDWpfddgapPSNQIVDDWLSLVK-IKFREEPGCCIAVHCVAGLGR-APVLVALALIEGGMKYEDA
.||||. ||. |. | .    .    .|   |.| |        ....... | .  | |.   . |  . |||  |. | | ...| |. | |...|.|
leelkengveyilnvtkeidnffpekfeylnirvyde.......eetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleea

VQFIRQKRRG
.......|. 
leyvkerrsv

PTPc_motif_SM00404 35-142 5.7e-11 37.5 In-house 21-125 (140) alignment
Range on Protein: 35-142
Range on HMM: 21-125/140.0
EELKKYGVTTIVRVCEATYDTtlVEKEGIHVLDWPFDDgaPPSNQIVDDWLSLVK-IKFREEPGCCIAVHCVAGLGRAPVLVALALI-EGGMKYEDAVQF
. |||.|.|... | |    |   |..|...|  | ||    ........ .... |.  |. |. . ||| ||. |   |..  |. . ......|..|
allkklgithvinvteevslt..kensgfqilqipldd..nekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayef

IRQKRrGAFN
....|  ...
vkerR.piis

subfamily_DSP1_pd Subfamily DSP1 35-138 4.5e-07 24.1 In-house 37-137 (163) alignment
Range on Protein: 35-138
Range on HMM: 37-137/163.0
EELKKYGVTTIVRV---CEATYDTtLVEKEGIHVLDWPFDDGAPPSNQIVDdWLSLVKikfreEPGCCIAVHCVAGLGRAPVLVALALI-EGGMKYEDAV
| ||. |.| |. |   .. .... | | . ... | | .|     ..... ..  ||     . .  . .|| ||. |.  |. . |. .  ...|.| 
eiLkslgitailnvskeldnvfed.lfeYkklkleDspkadislvfeevie.fidevk.....kknGkvlihCqaGisRsstlclaylmktkrvsleeaf

QFIRQKRR
.|..|.| 
dfvkqrRs

subfamily_DSP19_pd Subfamily DSP19 35-139 3.1e-06 21.6 In-house 31-132 (152) alignment
Range on Protein: 35-139
Range on HMM: 31-132/152.0
EELKKYGVTTIVRVCEATYDT--TLVEKEGIHVLDWPFDDgappSNQIVDDWLSLVKIKFREEpgCCIAVHCVAGLGRAP-VLVALALIEGGMKYEDAVQ
|.||. ..| |. |   . ..  . ..   |..|| |  |      .. .. |  ..   ...   .. ||| ||  |.. | .|  . .  ...|.|..
eilkekkitHilnvatgvpnvfpkdftylsieilDlpetd....llsylkealdFieearskd..gavlvHCnAGvSRsasvviaylmkkeelsleeale

FIRQKRRG
 .|..|. 
lvrearpc

subfamily_DSP8_pd Subfamily DSP8 36-150 9.5e-07 22.5 In-house 35-145 (159) alignment
Range on Protein: 36-150
Range on HMM: 35-145/159.0
ELKKYGVTTIVRVCEATYDTTLVEKEgiHVLDWPFDDGAppSNQIVDDWLSLVK-I-KFREEPGcCIAVHCVAGLGRAPV-LVALALIEGGMKYEDAVQF
 |.|.|.. .. . .   ..  ....  ..|  |  |    ...... . . |. | | ..| | .. ||. ||  |..   .|  . .  |....| .|
llsklgisyvlnasnscpkleelkes..kflrvPvkDky..dekllpwfdksvefidkakseng.rvlvhvlaGisrsatvaiayimktlemsldeayrf

IRQKRrgAFNSKQLLYLE
...||  .  |..| .|.
vkekr..ptispnlnflg

subfamily_RNGTT_pd Subfamily RNGTT 41-163 4.3e-09 30.3 In-house 56-174 (189) alignment
Range on Protein: 41-163
Range on HMM: 56-174/189.0
GVTTIVRVCEATYDTTLVEKEGIHVLDWPFD-DGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEG-GMKYEDAVQFIRQKRR
|.   .   .  ||.  .|||||.         |. |... |. . .||.  |...| . |.|||  |  |.  |..  |.|   .. |.||.  .. | 
glvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRp

GAfnskqlLYLEKYRPKMRLRFKDS
        .| |.|. ..  |..|.
pG......iykedylkellrrYadv

0048567 (Phosphotyrosine protein) phosphatases II 45-151 2.2e-12 41.6 In-house 20-132 (157) alignment
Range on Protein: 45-151
Range on HMM: 20-132/157.0
IVRVCEATYDTTLV-EKEGIHVLDWPFDDGaPPSNQIVDDWLSLVKIK--FREEPGCCIAVHCVAGL---GRAPVLVAL-ALIEGGMKYEDAVQFIRQKR
 .|. . .|..      .|.. .|. ||.| |..  |. ..  ... .  . |. |. ||||| |||   ||. .|... ...  |.  |.|....|. |
lprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr

RGAFNSKQLLYLEK
 |     .  ||. 
pgsvpfrdasylls

subfamily_PTPRA_pd Subfamily PTPRA 49-131 3.7e-06 21.0 In-house 182-262 (330) alignment
Range on Protein: 49-131
Range on HMM: 182-262/330.0
CEATYDTTLVEKEGIHVLDWPfDDGAPPSNQIVDDWLSLVKIKFREEPGcCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQ
 .|| . .    . .|   || | | |   . . . |  || . . . |  | ||| || ||.  ...|  .   .| |  | 
pdatrekksrlvrqfhftswP.dvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvd

subfamily_PTPDC1_pd Subfamily PTPDC1 52-147 2.3e-12 41.8 In-house 72-165 (182) alignment
Range on Protein: 52-147
Range on HMM: 72-165/182.0
TYDTTLVEKEGIHVLDWPFDDGAPPSNQIVddwLSLVKIK-FREEPGcCIAVHCVAGLGRAPVLVALALI-EGGMKYEDAVQFIRQKRRGAFNSKQLL
.||.  . ..|| |  ....|   .| . .   | .||.  |  . |  .|||| |||||. ||.|  |.    .. |.|....|.||  . .... .
sYdlealmeqgiyvynfgwkDygvasleri...Ldivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqv

subfamily_PTPMT1_pd Subfamily PTPMT1 54-154 5.5e-09 30.7 In-house 65-166 (171) alignment
Range on Protein: 54-154
Range on HMM: 65-166/171.0
DTTLVEKEGIHVLDWPFDDGA-PPSNQIVDDWLSLVKikFREEPGCCIAVHCVAGLGRAPVLVALALI-EGGMKYEDAVQFIRQKRRG-AFNSKQLLYLE
 |   .|.|.. |  .  | .  |. . . . . ...     . | .. ||| || ||.  |||  |. .  .. |.|......||.    ..||.  |.
steewkklgveqlqlatvDfteapdleklekgvefie..kvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalq

KYRP
.|. 
eyee

subfamily_PTPN13_pd Subfamily PTPN13 61-145 2.9e-07 25.1 In-house 169-256 (273) alignment
Range on Protein: 61-145
Range on HMM: 169-256/273.0
EGIHVLDWPfDDGAPPSNQIVDDWLSLVKiKFREePGCCIAVHCVAGLGRAPVLVALALIEGG------MKYEDAVQFIRQKRRGAFNSKQ
  ..  .|| | | | | . .   .. |. ....     |.||| ||.||. .|...  . |       .. .. |. .|..|.|   .|.
ahlnfvkwP.dhgvPssaaellqfvaevr.rlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkd

Y_phosphatase Protein-tyrosine phosphatase 62-146 8.2e-10 33.9 Pfam-A 137-226 (235) alignment
Range on Protein: 62-146
Range on HMM: 137-226/235.0
GIHVLDWPfDDGAPPSnqiVDDWLSLVKIKFREE--PGCCIAVHCVAGLGRAPVLVALALIEGGMKY------EDAVQFIRQKRRGAFNSKQ-L
 .|. .|| | |.| |   ... |.|..   ...      . ||| || ||. ..||| ..   ..        ..|. .|..|.|...| . .
qlhytnWp.dhgvpes...pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqY

Y_phosphatase Protein-tyrosine phosphatase 62-146 8.2e-10 33.9 In-house 137-226 (235) alignment
Range on Protein: 62-146
Range on HMM: 137-226/235.0
GIHVLDWPfDDGAPPSnqiVDDWLSLVKIKFREE--PGCCIAVHCVAGLGRAPVLVALALIEGGMKY------EDAVQFIRQKRRGAFNSKQ-L
 .|. .|| | |.| |   ... |.|..   ...      . ||| || ||. ..||| ..   ..        ..|. .|..|.|...| . .
qlhytnWp.dhgvpes...pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqY

subfamily_PTPRB_pd Subfamily PTPRB 62-132 3.6e-06 21.2 In-house 183-253 (293) alignment
Range on Protein: 62-132
Range on HMM: 183-253/293.0
GIHVLDWPfDDGAPPSNQIVDDWLSLVKIKF-REEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQF
  | . || | | | . . . |..  |. .  ...    | ||| ||.||. ...||  .   .. || |. 
qyhftsWp.dhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdi

PTPc_DSPc_SM00012 63-145 2.4e-10 35.9 In-house 5-94 (105) alignment
Range on Protein: 63-145
Range on HMM: 5-94/105.0
IHVLDWPFDdGAPPSNQIVDDWLSLVKIKFREEP-GCCIAVHCVAGLGRAPVLVALALIEGGMKYE-------DAVQFIRQKRRGAFNSKQ
.|...||   |.| . . . ..|  || . ...  .  . ||| || ||. ..|||...   ...|       . |. .|..|.|......
yhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqtee

subfamily_DSP23_pd Subfamily DSP23 63-142 2.2e-08 28.9 In-house 52-130 (148) alignment
Range on Protein: 63-142
Range on HMM: 52-130/148.0
IHVLDWPFDDGAPPSNQIVDDWLSLVKIkfREEPGCCIAVHCVAGLGRAPVLVALALI-EGGMKYEDAVQFIRQKRRGAFN
. .     ||  ||. . |.... .|.    || .  ..|||. | ||.  ..|  |. | ..   .|.  .|..| |. .
ltlvrlriddyhppaleqvvefvrvvee..aeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsve

subfamily_PTPN12_pd Subfamily PTPN12 63-127 1.8e-06 22.1 In-house 175-237 (290) alignment
Range on Protein: 63-127
Range on HMM: 175-237/290.0
IHVLDWPfDDGAPPSNQIVDDWLSLVKiKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYE
.|  .|| | | | | . . . ..||. ...|.    ..||| || ||. ...|. ..   .| |
fhYtaWP.DhgvPssaksllelielvr.elqesedaPlvvhCsaGvGrtGtiiaidyvrellkae

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 63-132 2e-06 22.2 In-house 182-252 (297) alignment
Range on Protein: 63-132
Range on HMM: 182-252/297.0
IHVLDWPFDDGAP-PSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQF
 . ..|| ..     | . . ...| |. .| ..  . . |||.||.||. ||...  .   .| |..|. 
yqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdi

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 63-133 6.1e-06 20.6 In-house 183-252 (305) alignment
Range on Protein: 63-133
Range on HMM: 183-252/305.0
IHVLDWPfDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFI
 .. ||| |.| | .   . . .  |. . ... |  . ||| ||.||. | .|. .    .| |. |.. 
yqltdWP.dhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvf

subfamily_PTPRN_pd Subfamily PTPRN 63-122 7.8e-06 19.8 In-house 192-249 (297) alignment
Range on Protein: 63-122
Range on HMM: 192-249/297.0
IHVLDWPfDDGAPPSNQIVDDWLSLVKIKFREePGCCIAVHCVAGLGRAPVLVALALIEG
 | | || . |.|.| . . ..   |   .|    | | ||| .| ||. | ... |.  
fhflswp.eegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvln

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 64-131 5.2e-07 24.0 In-house 181-246 (288) alignment
Range on Protein: 64-131
Range on HMM: 181-246/288.0
HVLDWPfDDGAPPSNQIVDDWLSLVKIKFREEPGcCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQ
. | || |.| | |.. . . |. ||.   .. |  | ||| ||.||... .||  .   .. || . 
qylaWp.dhgvPeskapllellrqvkvanqadtg.piivhCsaGvGrtgtFialdalidaveeedyiD

subfamily_DSP11_pd Subfamily DSP11 76-138 5e-06 20.5 In-house 93-158 (178) alignment
Range on Protein: 76-138
Range on HMM: 93-158/178.0
PSNQIVDDWLSLVKIK--FREEPGCCIAVHCVAGLGRAPVLVALALIE-GGMKYEDAVQFIRQKRR
|....|... . ||     ... .  |.|||  |. |.  |.   ||.  |.. |||..   . | 
pkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearG

subfamily_DSP3_pd Subfamily DSP3 96-149 9.8e-07 22.5 In-house 96-150 (162) alignment
Range on Protein: 96-149
Range on HMM: 96-150/162.0
PGCCIAVHCVAGLGRAPVL-VALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYL
.   . ||||.|. |...| .|  .|   |.  .|.. .|.||.   |.  |  |
kegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqL