Gene PTP4A1 in Homo sapiens

Synonym: HH72, PRL-1, PRL1, PTP(CAAX1), PTPCAAX1, RP5-1148A21.2, PTP4A1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PRL
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP035_AA protein Get Run
HsapP035_AA_6-159 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045450 (Phosphotyrosine protein) phosphatases II 4-152 2.2e-32 108.4 In-house 94-299 (307) alignment 
Range on Protein: 4-152
Range on HMM: 94-299/307.0
MNRPAPVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTL------------------------------------------VEKE
......... .....|..| .|.. |...|.. |...|||.||...| ....                                             ..|
vpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtge

GIHVLDWPF----DDGAPPSNQIVDDWLSLVKIKFREE-PGCCIAVHCVAGLGRAPVLVALALIEGG---------MKYEDAVQFIRQKRRGAF-NSKQL
...|  ...    |.|.||| ... |.. .|.  ..|  .|....||| ||.||.....|. |.  .         . ...||...|..| ||. |  |.
srtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy

LYLEKY
 .| ..
rflyea
0043147 (Phosphotyrosine protein) phosphatases II 8-167 3.1e-44 146.1 In-house 11-170 (172) alignment 
Range on Protein: 8-167
Range on HMM: 11-170/172.0
APVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAG
 .....|. .||..|. |.. ||..|.. ||..|.|.||...| .||..|.|..||..| .|..|. .|. ......|.... .. ..||....|||.||
syldlyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaG

LGRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFKDSNGHR
.||...|||. |.. |...|.||...|.||.||. ... ... .|  |..|..|||....
vgRtgtlvaaylmllglsleeavalvrekRpgavqnpsqyrflyyfeklllllkdslaek
0036282 (Phosphotyrosine protein) phosphatases II 8-153 6.3e-32 106.0 In-house 8-166 (174) alignment 
Range on Protein: 8-153
Range on HMM: 8-166/174.0
APVEVTYKNMRFLITHNPTNatlnkFIEELKKYGVTTIVRVCEATYDT------------TLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREE
 |. ..| . |....  |..     |.|.||..|.||.|...|  ..             .  |..||..|..|..|. .|. .|.......|.  . | 
spldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsed

PGCCIAVHCVAGLGRAPVLVALALIEGGM--KYEDAVQFIRQKR----RGAFNSKQLLYLEKYR
||....||| ||.||...|||. |.. |.  ...||....|..|    ..  .  |. .| ...
pggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
subfamily_PRL_pd Subfamily PRL 9-157 1.8e-80 262.3 In-house 2-150 (151) alignment 
Range on Protein: 9-157
Range on HMM: 2-150/151.0
PVEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGL
.||..||.||||||..||.|||.||||||||..|.|.|||||.||||. .|||||.|||..|||||.|....|..||.|.| ||.|||....||||||||
eveieykkmrflitdrPtdatlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGl

GRAPVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMR
||||||||||||| ||||||||.|||.|||||.||||| .||||..|..
GraPvlvalalieaGmkyedavefirekrrgainskqlkflekykakkk
0040439 (Phosphotyrosine protein) phosphatases II 10-152 2e-36 121.3 In-house 47-241 (249) alignment 
Range on Protein: 10-152
Range on HMM: 47-241/249.0
VEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEAT---------------------------------------------YDTTLVEKEGIH
....| ..||..|  |.. |...|.. |...|.|.||.... .                                             || . ..  .|.
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

VLDWPfDDGAPPSNQIVDDWLSLVKIKFREE-PGCCIAVHCVAGLGRAPVLVALALI------EGGMKYEDAVQFIRQKRRGAF-NSKQLLYLEKY
..||| |.|.||| ....|.. .|.  ..|  .|....||| ||.||.....|. |.      |.|. .|.||...|..|.||. |  |. .| ..
ytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
0042113 (Phosphotyrosine protein) phosphatases II 10-152 1.5e-31 105.1 In-house 45-238 (245) alignment 
Range on Protein: 10-152
Range on HMM: 45-238/245.0
VEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEAT---------------------------------------------YDTTLVEKEGIH
| . . . .|..|  |.. |...|.. |...|.||||...| .                                             .|    |   .|
vdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

VLDWPfDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALI------EGGMKYEDAVQFIRQKRRGAF-NSKQLLYLEKY
 |.|| |.|.|.. ....|.|..|.   .| ..  ..||| ||.||. ...|. |.      |.|.  |.||...|..|.||. .  |. .| ..
ylpwp.dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0040438 (Phosphotyrosine protein) phosphatases II 10-152 3.9e-30 100.6 In-house 79-271 (317) alignment 
Range on Protein: 10-152
Range on HMM: 79-271/317.0
VEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEAT---------------------------------------------YDTTLVEKEGIH
|.. .....|..|  |.. |...|.. ....|||.||...| .                                             .| . ..   .|
vdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfh

VLDWPfDDGAPPSNQIVDDWLSLVKIKFReEPGCCIAVHCVAGLGRAPVLVALALI------EGGMKYEDAVQFIRQKRRGAF-NSKQLLYLEKY
 ..|| |.|.||| ... |.|..|. ... .||....|||.||.||. ...|. |.      |||. .|.||...|..|.||. .  |. .| ..
ytgWp.dhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0047943 (Phosphotyrosine protein) phosphatases II 10-146 2.1e-28 95.0 In-house 70-260 (273) alignment 
Range on Protein: 10-146
Range on HMM: 70-260/273.0
VEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTT----------------LVEKEG-------------------------------
|.. .....|..| .|.. |...|.  .....|..||...| ...                   ..|                                 
vdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvt

-IHVLDWPfDDGAPPSNQIVDDWLSLVKIKFREE-PGCCIAVHCVAGLGRAPVLVALALI------EGGMKYEDAVQFIRQKRRGAFNSKQL
 .|...|| |.|.||| ... ... ||. ....   .  ..|||.||.||. ...|| |.      |||. ...||...|..| |.. . . 
hfhytgwp.dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeq
0051299 (Phosphotyrosine protein) phosphatases II 10-145 1.1e-27 92.7 In-house 85-273 (288) alignment 
Range on Protein: 10-145
Range on HMM: 85-273/288.0
VEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEAT-------------------------------------------------YDTTLVEK
... .....|..|  |.. |...|   . ...|..||.... .                                                 .| .  . 
idgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtv

EGIHVLDWPfDDGAPPSNQIVDDWLSLVKIKFReEPGCCIAVHCVAGLGRAPVLVALALI------EGGMKYEDAVQFIRQKRRGAFNSKQ
  .|...|| |.|.|.| . . |.| ||. ...  .|....||| ||.||. ...|| |.      |||. ...||...|..| |.... .
thfhytnwp.dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe
0036941 (Phosphotyrosine protein) phosphatases II 10-148 3.7e-25 84.3 In-house 71-276 (297) alignment 
Range on Protein: 10-148
Range on HMM: 71-276/297.0
VEVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVC--------------------------------------EATYDTTLVEKEG---------
|.. . ...|..|. |.. |...|   . ...||.|| ..                                      ...| .. .| .          
vdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtv

--IHVLDWPfDDGAPPSNQIVDDWLSLVKIKFREE-PGCCIAVHCVAGLGRAPVLVALAL---------IEGGMKYEDAVQFIRQKRRGAFNSKQ-----
  .|...|| |.|.|.| ... |.. ||. . ..  .|  . |||.||.||. ...|. |         .|||. . .||...|..| ||. . .     
thfhytgwp.dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl

----LLY
    | .
yeallel
0049260 (Phosphotyrosine protein) phosphatases II 11-152 7.2e-40 131.5 In-house 3-144 (152) alignment 
Range on Protein: 11-152
Range on HMM: 3-144/152.0
EVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGR
.. .....|..|. |.. ||..|.. ||..|.||||...| .... | ....|..| .|..|. .|.. .. ..| |.  |.....|....|||.||.||
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgR

APVLVALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKY
...|||. |.. |...|.||...|.|| ||. ... |.. ..
tgtlvaaylmllgvsleeavalvrekRpgavpnpgqlrflye
0043336 (Phosphotyrosine protein) phosphatases II 11-149 1.9e-30 101.7 In-house 82-269 (278) alignment 
Range on Protein: 11-149
Range on HMM: 82-269/278.0
EVTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEAT--------------------------------------------YDTTLVEKEGIHVL
..  ....|..|  |.. |...|.. ....||||||...| .                                            .|    .  ..| |
dgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhyl

DWPfDDGAPPSNQIVDDWLSLVKIKFReEPGCCIAVHCVAGLGRAPVLVALALI------EGGMKYEDAVQFIRQKRRGAF-NSKQLLYL
.|| |.|.|.| ... |.|  |. ...  .. ...|||.||.||. ...|| |.      |||. .|.||...|..| ||. .  |. .|
gwp.dhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfl
0050432 (Phosphotyrosine protein) phosphatases II 11-146 2.9e-28 94.5 In-house 100-287 (308) alignment 
Range on Protein: 11-146
Range on HMM: 100-287/308.0
EVT--YKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTT------LVEKEG----------------------------------------
 .   .....|..|  |.. |...|.  . ...|..||.... ...          ...|                                        
dgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtv

--IHVLDWPfDDGAPPSNQIVDDWLSLVKIKFreePGCCIAVHCVAGLGRAPVLVALALI------EGGMKYEDAVQFIRQKRRGAFNSKQL
  .| ..|| |.|.||| .|. |.| ||. ..   ||. |.||| ||.||. ...|| |.      |||. ...||...|..| |...... 
thfhytnWp.dhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeq
0046845 (Phosphotyrosine protein) phosphatases II 12-145 9.6e-26 86.2 In-house 72-261 (284) alignment 
Range on Protein: 12-145
Range on HMM: 72-261/284.0
VTYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATY-----------------------------------------------DTTLVEKEGIH
.||....|..|  |.. |...|   . ...|..|| ..| .                                                .   ..   .|
ltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfh

VLDWPfDDGAPPSNQIVDDWLSLVKIKFRE-EPGCCIAVHCVAGLGRAPVLVALALIEG---------GMKYEDAVQFIRQKRRGAFNSKQ
...|| |.|.||| ... ..| ||.  ... ..|. |.||| ||.||. ...|| |.           |. ...||...|..| |.... .
ytswp.dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle
0041856 (Phosphotyrosine protein) phosphatases II 13-161 1.3e-33 111.5 In-house 30-174 (182) alignment 
Range on Protein: 13-161
Range on HMM: 30-174/182.0
TYKNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSnqiVDDWLSLVKIKFReePGCCIAVHCVAGLGRAP
 ....||..|. |.. |...|.. ||..|.||||...|  |. .|.|..||..|..|..|. .|.   .|..|.....  .  .|....||| ||.||..
slpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd...ldelldfieevle..eggpvlVHCsaGvgRtg

VLVALALIE-GGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFK
.|||. |..  |. .|.||...|..| |.. . . .... .   ..|..|
tlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllk
0039614 (Phosphotyrosine protein) phosphatases II 13-160 1.4e-32 108.8 In-house 96-292 (297) alignment 
Range on Protein: 13-160
Range on HMM: 96-292/297.0
TYK-NMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYD----------------------TTLVEKEG-------------------IHVLDWPf
 .. ...|..|  |.. |...|.. ....|||.||.... ...                      ..  ...|                   .....|| 
ydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp.

DDGAPPSNQIVDDWLSLVKIKFREE-PGCCIAVHCVAGLGRAPVLVALALI------EGGMKYEDAVQFIRQKRRGAF-NSKQLLYLEKYRPKMRLRF
|.|.||| ......| ||.  ..|  .|....|||.||.||. ...|. |.      |||. ...||...|..|.||. .  |. .| ..  ....|.
dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
0045098 (Phosphotyrosine protein) phosphatases II 14-161 3.2e-34 114.0 In-house 62-276 (278) alignment 
Range on Protein: 14-161
Range on HMM: 62-276/278.0
YkNMRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATYDT----------------------------------------------TLVEKEGIHVLD
| ...|..|  |.. |...|.. |...|.|.||...| ....                                              .  |. |...|.
y.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlh

W-PFDDGAPPSNQIVDDWLSLVKIKFR---------------EEPGCCIAVHCVAGLGRAPVLVALALIEG----GMKYEDAVQFIRQKRRG-AF-NSKQ
. |..|. .||. |.. .|.|..   .               ...|....||| ||.||. .|||. |.      |. ...||...|..|.| |. |  |
ylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleq

LLYLEKYRPKMRLRFK
. .|...  ...||.|
yrflyefllelllrgk
0037934 (Phosphotyrosine protein) phosphatases II 15-152 8.7e-27 89.6 In-house 44-237 (243) alignment 
Range on Protein: 15-152
Range on HMM: 44-237/243.0
KnmRFLITHNPTNATLNK----FIEELKKYGVTTIVRVCEAT------------------------------------------YDTTLVEKEGIHVLDW
.  |. .|  |.. |..     |.. |...|.|.|| ..| .                                          .|.. .....||.. .
p..rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhyl

PFDDGAPPS-NQIVDDWLSLVKIKFRE-------EPGCCIAVHCVAGLGRAPVLVALALIEG--GMKYEDAVQFIRQKRRG-AF-NSKQLLYLEKY
|. |. .|.  ... |.|. |.   .|        .|  ..|||.||.||. .|.|. |.    |. .|.||...|..| | |. .  |. .| ..
pwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
0049772 (Phosphotyrosine protein) phosphatases II 17-153 1.2e-24 83.1 In-house 84-274 (314) alignment 
Range on Protein: 17-153
Range on HMM: 84-274/314.0
MRFLITHNPTNATLNKF--------------------------------------------------------------IEELKkygvttivrvcEATYD
..|..| .|.. |.. |                                                              .|.||           | .||
lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk...........eelyd

TTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKfreEPGCCIAVHCVAGLGRAP--VLVALALIEGGMKYEDAVQFIRQKRR-----GAFNSKQLl
  |.|..||..|..|..|| .|. ...|..| ...     ..| ...||| || ||..  |..|. ..  |. .|.|....|.||      |.... .. 
pelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnpgfieqleq.

YLEKYR
|.....
yefile
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 17-125 6.6e-06 19.8 In-house 88-197 (392) alignment 
Range on Protein: 17-125
Range on HMM: 88-197/392.0
MRFLITHNPTNATLNKFIEELKKYGVTTIVRVCEATY-DTT--LVEKEGIHVLDWPfDDGAPPSNQIVDDWLSLVKIKFREEPgCCIAVHCVAGLGRAPV
  .. .  |  |.|. | . . .  ||||. | .    |           |. .|| |.. |     .  ..  ||..| .     . .|| ||.||. |
kayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgddartvaqfhftewP.dkdvpkhtssllkfikevkadfGqyt.hpliihcsagvgrtgv

LVALALIEGGMK
....  .    |
visidsvvahak
0038934 (Phosphotyrosine protein) phosphatases II 18-148 1.1e-39 131.4 In-house 19-168 (194) alignment 
Range on Protein: 18-148
Range on HMM: 19-168/194.0
RFLITHNPTNATLNKFIEELKKYGVTTIVRVC----------------EATYDTTLVEKEGIHVLDWPFDD-GAPPSNQIVDDWLSLVKIKFREEPGCCI
||.... |.. .|.|.||||........||..                | .||....|| ||..|..|| | |..||..|....|.||. ...| ||...
rfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvv

AVHCVAGLGRAPVLVALALIE-GGMKYEDAVQFIRQKRRGAFNSKQL-LY
||||.|||||...||| .||.  ||..|.|....|.||.||... .   .
aVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdylea
0046846 (Phosphotyrosine protein) phosphatases II 18-155 2.6e-33 110.6 In-house 24-171 (176) alignment 
Range on Protein: 18-155
Range on HMM: 24-171/176.0
RFLITHNPTNATLNKFIEELKKYGVTTIVRVCEA--------TYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEpgCCIAVHCVAGLG
|...|. |.. || .|.|.||..|.|..|...|         ...  ..||.||..| .|..|. .|. ......| ...   .|    ...|||.||.|
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsaGig

RAPVLVALALIEG--GMKYEDAVQFIRQKRR-GAF-NSKQLLYLEKYRPK
|...|||. |.|   |...|.|....|..|. ||. . .|. .|...  .
RtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
0051429 (Phosphotyrosine protein) phosphatases II 18-152 1.9e-18 62.6 In-house 23-220 (272) alignment 
Range on Protein: 18-152
Range on HMM: 23-220/272.0
RFLITHNPTNATLNKFIEElKKYGVTTIVRVCEAT---YDTTLVEKEGIHVLDWPFDDGAPPSNQIV---------------------------------
|.. . .|...| . |    |..|..||| ... .   .. .  . .||..| .|. | ..|.  .                                  
rlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsageare

----------------DDWLSLVKIKFReepGCCIAVHCVAGLGRAPVLVALALIEGGMK--------------YEDAVQFIRQKRRGAF-NSKQLLYLE
                .  |.|...  .   |  . ||| || .|  ..||| |.  |.               .|.||. .|..|.||. .  |.|.| 
vmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqylfly

KY
..
ea
0051082 (Phosphotyrosine protein) phosphatases II 19-150 2.4e-26 87.6 In-house 15-145 (151) alignment 
Range on Protein: 19-150
Range on HMM: 15-145/151.0
FLITHNPTNatlnKFIEELKKYGVTTIVRVCEAT---YDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLV
....  |..     |.|.||..|..||| ... .   |.. .....||.||..|..|  .|. ..  |..  .  .... .. ...||| ||.||  .||
lyrsggpla....dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlv

ALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYLE
|| |.  |. .|.|....|.|| |.....|  ...
alylmllgvsleealeeyrlkrpgvvqpnqqflfq
subfamily_STYX_pd Subfamily STYX 25-138 3e-06 20.4 In-house 23-138 (166) alignment 
Range on Protein: 25-138
Range on HMM: 23-138/166.0
PTNATLNKFIEELKKYGVTTIVRVCEAtYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKI--KFREEPGCCIAVHCVAGLGRAPVLVALALIEG
|  |...  .| ||| |.| || . ..  ...|.  .  . . .   | |  . . .  .|  ||       . |  . ||  ||. |.  ||   ..| 
pysaamksklevlkkhgithivcirqn.ieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimet

-GMKYEDAVQFIRQKRR
 |.|| .| ......| 
yglkyreafayvqerrf
0044763 (Phosphotyrosine protein) phosphatases II 26-156 8.2e-31 102.4 In-house 37-170 (178) alignment 
Range on Protein: 26-156
Range on HMM: 37-170/178.0
TnatlNKFIEELKKYGVTTIVRVCEATY------DTTLVEKEGIHVLDWPFDDGAPPS-NQIVDDWLSLVKIKFReEPGCCIAVHCVAGLGRAPVLVALA
.     ...| ||..|.|.||...| ..      |   .|..||..| .|..|. .|.  ....... ...     |.|....||| ||.||...|||. 
p....addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaay

LI-EGGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKM
|. . |. .|.|....|..|..  |  || .|... ...
lmkklglsleeaielvrerRpivpnpgqlrqLyefelrl
PTEN_1 27-155 4e-22 74.0 In-house 52-190 (196) alignment 
Range on Protein: 27-155
Range on HMM: 52-190/196.0
NATLN-KFIEELKKYGVTTIVRVCE------ATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEP-GCCIAVHCVAGLGRAPVLVALA
..... .. ..||. |.|..|...|      ..|| .. .|.|. .|. |..|  .|| . . |..  ..   .. | | ...||| |||||  ..||  
slkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaay

LIEGG-MKYEDAVQFIRQKR-RGAFNSKQLLYLEKYRPK
|.. | . ...|....|.|| .||.|| ..  |..|  .
LmykgkltadeAlelvrekRppgapnspsqerlleyfae
subfamily_PTEN_pd Subfamily PTEN 29-138 1.4e-10 36.4 In-house 49-157 (184) alignment 
Range on Protein: 29-138
Range on HMM: 49-157/184.0
TLNKFIEELKkYGVTTIVRV-CEATYDTTLVekeGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMK--
 . ||.|. .  .   |  .  | .||.. .     .|  .||||  ||. ..... .. ..  . |..   ..||| || ||. ||..  |.. ..   
dvvkflekkh.kdhykiynlrserkydskkf...dgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllek

YEDAVQFIRQKRR
 |.|...  ..| 
aeealelfaeaRt
subfamily_CDKN3_pd Subfamily CDKN3 30-156 1.4e-09 31.8 In-house 59-195 (202) alignment 
Range on Protein: 30-156
Range on HMM: 59-195/202.0
LNKFIEELKKYGVTTIVRVCEA----TYDT----TLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKFREEPGccIAVHCVAGLGRAPVLVAL--AL
..| |||||  ||  .  .|       |       | .. |. |  .|. ||  |.     . |  ..| ...  .    |||  ||||. ...|    .
vekdieelksqgvedvfvlctrgelskyrvrrlldlyqqaglivhhypiadglvpdiasclkileelrinlkayrk..tlvhcygglgrsslviacllly

IEGGMKYEDAVQFIRQKRR-GAF-NSKQLLYLEKYRPKM
..  ....||.. .|. .  .|    ||  ||...| |.
lddtiepkdaidklrdlkgsraiqtvkqynylsefrdkl
subfamily_CDC14_pd Subfamily CDC14 31-155 8e-21 69.2 In-house 202-322 (328) alignment 
Range on Protein: 31-155
Range on HMM: 202-322/328.0
NKFIEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDGAPPSNQIVDDWLSLVKIKfreepGCCIAVHCVAGLGRAPVLVALALIE-GGMKYEDA
.|..|  .|..|||.||. .  || .  ...|..  |  | ||. ||..||  .|....          ||||| |||||.  |.|  |..  ..  ..|
eklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrftaaea

VQFIRQKRRGAFNSKQLLYLEKYRPK
. ..|  | |   ..|  .||. . .
iawlricrPGsvigpqqkfleekqaa
subfamily_DSP15_pd Subfamily DSP15 32-140 7.6e-08 26.6 In-house 18-122 (151) alignment 
Range on Protein: 32-140
Range on HMM: 18-122/151.0
KFIEELKKYGVTTIVRVCEatyD-TTLVEKegIHVLDWPFDDGAP-PSNQIVDDWLSLVKiKFREEPGCCiAVHCVAGLGRAPVLVALALIE-GGMKYED
|  | ||.  .|.|. | .   .   |...  |. .  . .| .    ......  ...  | | . . .  |||.||. |.  ||.. |.    ....|
kdeelLkeknithilsvhd...nakkllkd..ieYkciaasDtpsaklskffkesvefih.kcRlkeenv.lvhClaGvsRsvtlvvaYlmtvtelnwrd

AVQFIRQKRRGA
|...|...|  |
alevikaaRsva
subfamily_DSP6_pd Subfamily DSP6 32-138 2.5e-06 21.1 In-house 30-135 (158) alignment 
Range on Protein: 32-138
Range on HMM: 30-135/158.0
KFIEELKKYGVTTIVRVCEAtYDTTLVEKEGIHVLDWPFDDGAPPS-NQIVDDWLSLVKIKfrEEPGCCIAVHCVAGLGRA-PVLVALALIEGGMKYEDA
. .| |||...  .. | .   . .  |.. .. |  | .| .     . . . ....      .  . . ||| ||. |.  | .|  . .  .  .||
snlevlkklkikyvlnvtsn.lpnkfeesgelkylqipiedhlsqnlakffPeaiefidea..rskkskvlvhClaGisrsvtvtlaylmkklalslnda

VQFIRQKRR
 ....... 
ydlvkkrks
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 32-120 2.7e-06 21.3 In-house 162-242 (305) alignment 
Range on Protein: 32-120
Range on HMM: 162-242/305.0
KFIEELKkYGVTTIVRVCEATYDTTLvEKEGIHVLDWPfDDGAPPSNQIVDDWLslvkIKFREEPGcCIAVHCVAGLGRAPVLVALALI
|| .. |   ||  | | | .  ...      |  ||| | | |.... . . |    .| |   |  |.||| ||.||.  .| |  |
kfrkdak.akvtetvlviegpgekar.kvthyhwidwp.drgvpaadlailell....ekarpskg.pivvhcsagigrtgsvvmleyi
0048179 (Phosphotyrosine protein) phosphatases II 34-154 2.6e-25 84.2 In-house 22-142 (144) alignment 
Range on Protein: 34-154
Range on HMM: 22-142/144.0
IEELKKYGVTTIVRVCEaTYDTTLVEKEGIHVLDWPFDDGAPPSN-QIVDDWLSLVKIKFReePGCCIAVHCVAGLGRAPVLVALALI-EGGMKYEDAVQ
.|.|||.|.||.....| .|. . .|.|||..| .|..|  .|.  ......| ...   .  .|....||| ||.||...|||. |. . |. .|.|..
lellkklgittvinlte.eyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklglsleeala

FIRQKRRGAF-NSKQLLYLEKYRP
..|..| ||. |  || .|..|..
lvrsrrpgavpnpgqlrfLleyek
0048076 (Phosphotyrosine protein) phosphatases II 34-154 9.9e-25 82.3 In-house 22-140 (145) alignment 
Range on Protein: 34-154
Range on HMM: 22-140/145.0
IEELKKYGVTTIVRVceaTYDTTLVEKEGIHVLDWPFDDGAPPSN-QIVDDWLSLVKiKFREEPgCCIAVHCVAGLGRAPVLVAL-ALIEGGMKYEDAVQ
.|.||..|.||....   |....|.|..||..| .|..|  .|.  ......| ... ....|. ....||| ||.||...|||.  ... |. .|.|..
lellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefie.ealkeg.gpvlVHCsaGvgRtgtlvaaylmlllgvsleeale

FIRQKRRGAF-NSKQLLYLEKYRP
..|..|.||. |  || .|...  
lvrsqrpgavpnpgqlrflyefel
DSPc Dual specificity phosphatase, catalytic domain 34-142 1.9e-11 39.0 Pfam-A 11-118 (133) alignment 
Range on Protein: 34-142
Range on HMM: 11-118/133.0
IEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDgaPPSNQIVDDWLSLVK-IKFREEPGCCIAVHCVAGLGRAPVLVALALI-EGGMKYEDAVQ
 . |.|.|.| .. | . .  . . .|. |. |. | .|    ...|...  ..|. |.  |. |. ..||| ||. | . |..  |. . ......|..
lalleklgitlvinvtkevpnnnaikkseieylripved..etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAye

FIRQKRrGAFN
|....| ....
fvkerr.skis
DSPc Dual specificity phosphatase, catalytic domain 34-142 1.9e-11 39.0 In-house 11-118 (133) alignment 
Range on Protein: 34-142
Range on HMM: 11-118/133.0
IEELKKYGVTTIVRVCEATYDTTLVEKEGIHVLDWPFDDgaPPSNQIVDDWLSLVK-IKFREEPGCCIAVHCVAGLGRAPVLVALALI-EGGMKYEDAVQ
 . |.|.|.| .. | . .  . . .|. |. |. | .|    ...|...  ..|. |.  |. |. ..||| ||. | . |..  |. . ......|..
lalleklgitlvinvtkevpnnnaikkseieylripved..etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAye

FIRQKRrGAFN
|....| ....
fvkerr.skis
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 34-134 2.7e-06 21.9 In-house 162-264 (319) alignment 
Range on Protein: 34-134
Range on HMM: 162-264/319.0
IEELKKYGVTTIvRVCEATYDTTLVEKEGIHVLDWPfDDGAPPSNQIVDDWLSL-VKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQ-
.|| ..| |  | .. | .  .   .    | | || | | | .   .   .    ... .|.    | ||| || ||. | ..|  .   || |. |. 
veetaeyvvrdi.elsedgkekdirkitqfhflGwp.dvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdv

--FIR
  |.|
ynfvr
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 34-134 3.4e-06 21.8 In-house 126-228 (284) alignment 
Range on Protein: 34-134
Range on HMM: 126-228/284.0
IEELKKYGVTTIvRVCEATYDTTLVEKEGIHVLDWPfDDGAPPSNQIVDDWLSL-VKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQ-
.|| ..| |  | .. | .  .   .    | | || | | | ..  .   .    ... .|.    | ||| || ||. | ..|  .   || |. |. 
veeseeyvvrdi.elsedgkekdirkirqfhflgwp.dvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldvlldrmkeekqvdv

--FIR
  |.|
ynfvr
subfamily_Slingshot_pd Subfamily Slingshot 34-139 5.1e-06 20.0 In-house 37-139 (169) alignment 
Range on Protein: 34-139
Range on HMM: 37-139/169.0
IEELKKYGVTTIVRVCEAT--YDTTLVEKEGIHVLDWpfddgapPSNQIVDDWLSLVK-IKFREEPGCCIAVHCVAGLGR-APVLVALALIEGGMKYEDA
.||||. ||. |. | .    .    .|   |.| |        ....... | .  | |.   . |  . |||  |. | | ...| |. | |...|.|
leelkengveyilnvtkeidnffpekfeylnirvyde.......eetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleea

VQFIRQKRRG
.......|. 
leyvkerrsv
PTPc_motif_SM00404 35-142 5.7e-11 37.5 In-house 21-125 (140) alignment 
Range on Protein: 35-142
Range on HMM: 21-125/140.0
EELKKYGVTTIVRVCEATYDTtlVEKEGIHVLDWPFDDgaPPSNQIVDDWLSLVK-IKFREEPGCCIAVHCVAGLGRAPVLVALALI-EGGMKYEDAVQF
. |||.|.|... | |    |   |..|...|  | ||    ........ .... |.  |. |. . ||| ||. |   |..  |. . ......|..|
allkklgithvinvteevslt..kensgfqilqipldd..nekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayef

IRQKRrGAFN
....|  ...
vkerR.piis
subfamily_DSP1_pd Subfamily DSP1 35-138 4.5e-07 24.1 In-house 37-137 (163) alignment 
Range on Protein: 35-138
Range on HMM: 37-137/163.0
EELKKYGVTTIVRV---CEATYDTtLVEKEGIHVLDWPFDDGAPPSNQIVDdWLSLVKikfreEPGCCIAVHCVAGLGRAPVLVALALI-EGGMKYEDAV
| ||. |.| |. |   .. .... | | . ... | | .|     ..... ..  ||     . .  . .|| ||. |.  |. . |. .  ...|.| 
eiLkslgitailnvskeldnvfed.lfeYkklkleDspkadislvfeevie.fidevk.....kknGkvlihCqaGisRsstlclaylmktkrvsleeaf

QFIRQKRR
.|..|.| 
dfvkqrRs
subfamily_DSP19_pd Subfamily DSP19 35-139 3.1e-06 21.6 In-house 31-132 (152) alignment 
Range on Protein: 35-139
Range on HMM: 31-132/152.0
EELKKYGVTTIVRVCEATYDT--TLVEKEGIHVLDWPFDDgappSNQIVDDWLSLVKIKFREEpgCCIAVHCVAGLGRAP-VLVALALIEGGMKYEDAVQ
|.||. ..| |. |   . ..  . ..   |..|| |  |      .. .. |  ..   ...   .. ||| ||  |.. | .|  . .  ...|.|..
eilkekkitHilnvatgvpnvfpkdftylsieilDlpetd....llsylkealdFieearskd..gavlvHCnAGvSRsasvviaylmkkeelsleeale

FIRQKRRG
 .|..|. 
lvrearpc
subfamily_DSP8_pd Subfamily DSP8 36-150 9.5e-07 22.5 In-house 35-145 (159) alignment 
Range on Protein: 36-150
Range on HMM: 35-145/159.0
ELKKYGVTTIVRVCEATYDTTLVEKEgiHVLDWPFDDGAppSNQIVDDWLSLVK-I-KFREEPGcCIAVHCVAGLGRAPV-LVALALIEGGMKYEDAVQF
 |.|.|.. .. . .   ..  ....  ..|  |  |    ...... . . |. | | ..| | .. ||. ||  |..   .|  . .  |....| .|
llsklgisyvlnasnscpkleelkes..kflrvPvkDky..dekllpwfdksvefidkakseng.rvlvhvlaGisrsatvaiayimktlemsldeayrf

IRQKRrgAFNSKQLLYLE
...||  .  |..| .|.
vkekr..ptispnlnflg
subfamily_RNGTT_pd Subfamily RNGTT 41-163 4.3e-09 30.3 In-house 56-174 (189) alignment 
Range on Protein: 41-163
Range on HMM: 56-174/189.0
GVTTIVRVCEATYDTTLVEKEGIHVLDWPFD-DGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEG-GMKYEDAVQFIRQKRR
|.   .   .  ||.  .|||||.         |. |... |. . .||.  |...| . |.|||  |  |.  |..  |.|   .. |.||.  .. | 
glvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRp

GAfnskqlLYLEKYRPKMRLRFKDS
        .| |.|. ..  |..|.
pG......iykedylkellrrYadv
0048567 (Phosphotyrosine protein) phosphatases II 45-151 2.2e-12 41.6 In-house 20-132 (157) alignment 
Range on Protein: 45-151
Range on HMM: 20-132/157.0
IVRVCEATYDTTLV-EKEGIHVLDWPFDDGaPPSNQIVDDWLSLVKIK--FREEPGCCIAVHCVAGL---GRAPVLVAL-ALIEGGMKYEDAVQFIRQKR
 .|. . .|..      .|.. .|. ||.| |..  |. ..  ... .  . |. |. ||||| |||   ||. .|... ...  |.  |.|....|. |
lprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivr

RGAFNSKQLLYLEK
 |     .  ||. 
pgsvpfrdasylls
subfamily_PTPRA_pd Subfamily PTPRA 49-131 3.7e-06 21.0 In-house 182-262 (330) alignment 
Range on Protein: 49-131
Range on HMM: 182-262/330.0
CEATYDTTLVEKEGIHVLDWPfDDGAPPSNQIVDDWLSLVKIKFREEPGcCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQ
 .|| . .    . .|   || | | |   . . . |  || . . . |  | ||| || ||.  ...|  .   .| |  | 
pdatrekksrlvrqfhftswP.dvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvd
subfamily_PTPDC1_pd Subfamily PTPDC1 52-147 2.3e-12 41.8 In-house 72-165 (182) alignment 
Range on Protein: 52-147
Range on HMM: 72-165/182.0
TYDTTLVEKEGIHVLDWPFDDGAPPSNQIVddwLSLVKIK-FREEPGcCIAVHCVAGLGRAPVLVALALI-EGGMKYEDAVQFIRQKRRGAFNSKQLL
.||.  . ..|| |  ....|   .| . .   | .||.  |  . |  .|||| |||||. ||.|  |.    .. |.|....|.||  . .... .
sYdlealmeqgiyvynfgwkDygvasleri...Ldivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqv
subfamily_PTPMT1_pd Subfamily PTPMT1 54-154 5.5e-09 30.7 In-house 65-166 (171) alignment 
Range on Protein: 54-154
Range on HMM: 65-166/171.0
DTTLVEKEGIHVLDWPFDDGA-PPSNQIVDDWLSLVKikFREEPGCCIAVHCVAGLGRAPVLVALALI-EGGMKYEDAVQFIRQKRRG-AFNSKQLLYLE
 |   .|.|.. |  .  | .  |. . . . . ...     . | .. ||| || ||.  |||  |. .  .. |.|......||.    ..||.  |.
steewkklgveqlqlatvDfteapdleklekgvefie..kvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalq

KYRP
.|. 
eyee
subfamily_PTPN13_pd Subfamily PTPN13 61-145 2.9e-07 25.1 In-house 169-256 (273) alignment 
Range on Protein: 61-145
Range on HMM: 169-256/273.0
EGIHVLDWPfDDGAPPSNQIVDDWLSLVKiKFREePGCCIAVHCVAGLGRAPVLVALALIEGG------MKYEDAVQFIRQKRRGAFNSKQ
  ..  .|| | | | | . .   .. |. ....     |.||| ||.||. .|...  . |       .. .. |. .|..|.|   .|.
ahlnfvkwP.dhgvPssaaellqfvaevr.rlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkd
Y_phosphatase Protein-tyrosine phosphatase 62-146 8.2e-10 33.9 Pfam-A 137-226 (235) alignment 
Range on Protein: 62-146
Range on HMM: 137-226/235.0
GIHVLDWPfDDGAPPSnqiVDDWLSLVKIKFREE--PGCCIAVHCVAGLGRAPVLVALALIEGGMKY------EDAVQFIRQKRRGAFNSKQ-L
 .|. .|| | |.| |   ... |.|..   ...      . ||| || ||. ..||| ..   ..        ..|. .|..|.|...| . .
qlhytnWp.dhgvpes...pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqY
Y_phosphatase Protein-tyrosine phosphatase 62-146 8.2e-10 33.9 In-house 137-226 (235) alignment 
Range on Protein: 62-146
Range on HMM: 137-226/235.0
GIHVLDWPfDDGAPPSnqiVDDWLSLVKIKFREE--PGCCIAVHCVAGLGRAPVLVALALIEGGMKY------EDAVQFIRQKRRGAFNSKQ-L
 .|. .|| | |.| |   ... |.|..   ...      . ||| || ||. ..||| ..   ..        ..|. .|..|.|...| . .
qlhytnWp.dhgvpes...pkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqY
subfamily_PTPRB_pd Subfamily PTPRB 62-132 3.6e-06 21.2 In-house 183-253 (293) alignment 
Range on Protein: 62-132
Range on HMM: 183-253/293.0
GIHVLDWPfDDGAPPSNQIVDDWLSLVKIKF-REEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQF
  | . || | | | . . . |..  |. .  ...    | ||| ||.||. ...||  .   .. || |. 
qyhftsWp.dhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdi
PTPc_DSPc_SM00012 63-145 2.4e-10 35.9 In-house 5-94 (105) alignment 
Range on Protein: 63-145
Range on HMM: 5-94/105.0
IHVLDWPFDdGAPPSNQIVDDWLSLVKIKFREEP-GCCIAVHCVAGLGRAPVLVALALIEGGMKYE-------DAVQFIRQKRRGAFNSKQ
.|...||   |.| . . . ..|  || . ...  .  . ||| || ||. ..|||...   ...|       . |. .|..|.|......
yhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqtee
subfamily_DSP23_pd Subfamily DSP23 63-142 2.2e-08 28.9 In-house 52-130 (148) alignment 
Range on Protein: 63-142
Range on HMM: 52-130/148.0
IHVLDWPFDDGAPPSNQIVDDWLSLVKIkfREEPGCCIAVHCVAGLGRAPVLVALALI-EGGMKYEDAVQFIRQKRRGAFN
. .     ||  ||. . |.... .|.    || .  ..|||. | ||.  ..|  |. | ..   .|.  .|..| |. .
ltlvrlriddyhppaleqvvefvrvvee..aeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgsve
subfamily_PTPN12_pd Subfamily PTPN12 63-127 1.8e-06 22.1 In-house 175-237 (290) alignment 
Range on Protein: 63-127
Range on HMM: 175-237/290.0
IHVLDWPfDDGAPPSNQIVDDWLSLVKiKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYE
.|  .|| | | | | . . . ..||. ...|.    ..||| || ||. ...|. ..   .| |
fhYtaWP.DhgvPssaksllelielvr.elqesedaPlvvhCsaGvGrtGtiiaidyvrellkae
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 63-132 2e-06 22.2 In-house 182-252 (297) alignment 
Range on Protein: 63-132
Range on HMM: 182-252/297.0
IHVLDWPFDDGAP-PSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQF
 . ..|| ..     | . . ...| |. .| ..  . . |||.||.||. ||...  .   .| |..|. 
yqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdi
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 63-133 6.1e-06 20.6 In-house 183-252 (305) alignment 
Range on Protein: 63-133
Range on HMM: 183-252/305.0
IHVLDWPfDDGAPPSNQIVDDWLSLVKIKFREEPGCCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQFI
 .. ||| |.| | .   . . .  |. . ... |  . ||| ||.||. | .|. .    .| |. |.. 
yqltdWP.dhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvf
subfamily_PTPRN_pd Subfamily PTPRN 63-122 7.8e-06 19.8 In-house 192-249 (297) alignment 
Range on Protein: 63-122
Range on HMM: 192-249/297.0
IHVLDWPfDDGAPPSNQIVDDWLSLVKIKFREePGCCIAVHCVAGLGRAPVLVALALIEG
 | | || . |.|.| . . ..   |   .|    | | ||| .| ||. | ... |.  
fhflswp.eegvPasaksllefrrkvnksyrG.rscpivvhcsdGaGrtGvyilidlvln
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 64-131 5.2e-07 24.0 In-house 181-246 (288) alignment 
Range on Protein: 64-131
Range on HMM: 181-246/288.0
HVLDWPfDDGAPPSNQIVDDWLSLVKIKFREEPGcCIAVHCVAGLGRAPVLVALALIEGGMKYEDAVQ
. | || |.| | |.. . . |. ||.   .. |  | ||| ||.||... .||  .   .. || . 
qylaWp.dhgvPeskapllellrqvkvanqadtg.piivhCsaGvGrtgtFialdalidaveeedyiD
subfamily_DSP11_pd Subfamily DSP11 76-138 5e-06 20.5 In-house 93-158 (178) alignment 
Range on Protein: 76-138
Range on HMM: 93-158/178.0
PSNQIVDDWLSLVKIK--FREEPGCCIAVHCVAGLGRAPVLVALALIE-GGMKYEDAVQFIRQKRR
|....|... . ||     ... .  |.|||  |. |.  |.   ||.  |.. |||..   . | 
pkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearG
subfamily_DSP3_pd Subfamily DSP3 96-149 9.8e-07 22.5 In-house 96-150 (162) alignment 
Range on Protein: 96-149
Range on HMM: 96-150/162.0
PGCCIAVHCVAGLGRAPVL-VALALIEGGMKYEDAVQFIRQKRRGAFNSKQLLYL
.   . ||||.|. |...| .|  .|   |.  .|.. .|.||.   |.  |  |
kegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqL