Gene PTP4A2 in Homo sapiens

Synonym: HH13, HH7-2, HU-PP-1, OV-1, PRL-2, PRL2, PTP4A, PTPCAAX2, ptp-IV1a, ptp-IV1b, BM-008, PTP4A2

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PRL
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP036_AA protein Get Run
HsapP036_AA_3-156 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045450 (Phosphotyrosine protein) phosphatases II 4-149 1.5e-31 105.7 In-house 97-299 (307) alignment 
Range on Protein: 4-149
Range on HMM: 97-299/307.0
PAPVEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDKAP------------------------------------------VEKEGIH
...... . ...|..| .|.. |...| . |...|||..|.... .... .                                           ..|...
lllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrt

VLDWPF----DDGAPPPNQIVDDWLNLLKTKFREE-PGCCVAVHCVAGLGRAPVLVALALIECG---------MKYEDAVQFIRQKRRGAF-NSKQLLYL
|  ...    |.|.||  ... |....... ..|  .|..|.||| ||.||.....|. |. ..         . ...||...|..| ||. |  |. .|
vthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfl

EKY
 ..
yea
0043147 (Phosphotyrosine protein) phosphatases II 5-159 5.8e-43 141.9 In-house 11-165 (172) alignment 
Range on Protein: 5-159
Range on HMM: 11-165/172.0
APVEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCVAG
 .....|  .||..|. |.. ||..| . ||..|.|..|.... .||. ..|..||..| .|..|. .|. ......|....... ..||..|.|||.||
syldlyyipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaG

LGRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFRD
.||...|||. |...|...|.||...|.||.||. ... ... .|  |..|...|
vgRtgtlvaaylmllglsleeavalvrekRpgavqnpsqyrflyyfeklllllkd
0036282 (Phosphotyrosine protein) phosphatases II 5-150 2.4e-32 107.4 In-house 8-166 (174) alignment 
Range on Protein: 5-150
Range on HMM: 8-166/174.0
APVEISYENMRFLITHNPTNatlnkFTEELKKYGVTTLVRVCDATYDK------------APVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREE
 |. .|| . |....  |..     | |.||..|.||.|....  ...               |..||..|..|..|. .|. .|.......... . | 
spldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsed

PGCCVAVHCVAGLGRAPVLVALALIECGM--KYEDAVQFIRQKR----RGAFNSKQLLYLEKYR
||..|.||| ||.||...|||. |...|.  ...||....|..|    ..  .  |. .| ...
pggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
subfamily_PRL_pd Subfamily PRL 6-154 2.1e-80 262.0 In-house 2-150 (151) alignment 
Range on Protein: 6-154
Range on HMM: 2-150/151.0
PVEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCVAGL
.|||.|..||||||..||.|||.||.|||||..|.|.||||..|||....|||||.|||..|||||.||...|..||.|||.||.|||...|||||||||
eveieykkmrflitdrPtdatlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGl

GRAPVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMR
|||||||||||||.||||||||.|||.|||||.||||| .||||..|..
GraPvlvalalieaGmkyedavefirekrrgainskqlkflekykakkk
0040439 (Phosphotyrosine protein) phosphatases II 7-149 5.5e-35 116.6 In-house 47-241 (249) alignment 
Range on Protein: 7-149
Range on HMM: 47-241/249.0
VEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDAT---------------------------------------------YDKAPVEKEGIH
.. .| ..||..|  |.. |...| . |...|.|..|.... .                                             ||. ...  .|.
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

VLDWPfDDGAPPPNQIVDDWLNLLKTKFREE-PGCCVAVHCVAGLGRAPVLVALALI------ECGMKYEDAVQFIRQKRRGAF-NSKQLLYLEKY
..||| |.|.||  ....|....... ..|  .|..|.||| ||.||.....|. |.      |.|. .|.||...|..|.||. |  |. .| ..
ytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyea
0042113 (Phosphotyrosine protein) phosphatases II 7-149 4.7e-31 103.5 In-house 45-238 (245) alignment 
Range on Protein: 7-149
Range on HMM: 45-238/245.0
VEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDAT---------------------------------------------YDKAPVEKEGIH
|  .. . .|..|  |.. |...| . |...|.||.|.... .                                             .|. . |   .|
vdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyh

VLDWPfDDGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCVAGLGRAPVLVALALI------ECGMKYEDAVQFIRQKRRGAF-NSKQLLYLEKY
 |.|| |.|.|.  ....|.|.....  .| ..  |.||| ||.||. ...|. |.      |.|.  |.||...|..|.||. .  |. .| ..
ylpwp.dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
0047943 (Phosphotyrosine protein) phosphatases II 7-143 6.5e-26 86.8 In-house 70-260 (273) alignment 
Range on Protein: 7-143
Range on HMM: 70-260/273.0
VEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDKA-------PVEKEG----------------------------------------
|.  . ...|..| .|.. |...|   .....|...|.... ....        | | ..                                        
vdgynlkrkfiatqgPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvt

-IHVLDWPfDDGAPPPNQIVDDWLNLLKTKFREE-PGCCVAVHCVAGLGRAPVLVALALI------ECGMKYEDAVQFIRQKRRGAFNSKQL
 .|...|| |.|.||  ... ....|.......   .  |.|||.||.||. ...|| |.      | |. ...||...|..| |.. . . 
hfhytgwp.dhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeq
0051299 (Phosphotyrosine protein) phosphatases II 7-142 1.2e-25 86.0 In-house 85-273 (288) alignment 
Range on Protein: 7-142
Range on HMM: 85-273/288.0
VEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDAT-------------------------------------------------YDKAPVEK
... . ...|..|  |.. |...|   . ...|.. |.... .                                                 .|. . . 
idgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtv

EGIHVLDWPfDDGAPPPNQIVDDWLNLLKTKFReEPGCCVAVHCVAGLGRAPVLVALALI------ECGMKYEDAVQFIRQKRRGAFNSKQ
  .|...|| |.|.|.  . . |.|.|......  .|..|.||| ||.||. ...|| |.      | |. ...||...|..| |.... .
thfhytnwp.dhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe
0036941 (Phosphotyrosine protein) phosphatases II 7-145 6.7e-23 76.8 In-house 71-276 (297) alignment 
Range on Protein: 7-145
Range on HMM: 71-276/297.0
VEISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDKA-------PVE------------------------------------------K
|.. . ...|..|. |.. |...|   . ...||..| ... . .         | |                                           
vdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtv

EGIHVLDWPfDDGAPPPNQIVDDWLNLLKTKFREE-PGCCVAVHCVAGLGRAPVLVALAL---------IECGMKYEDAVQFIRQKRRGAFNSKQ-----
  .|...|| |.|.|.  ... |...|.... ..  .|  | |||.||.||. ...|. |         .|.|. . .||...|..| ||. . .     
thfhytgwp.dhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl

----LLY
    | .
yeallel
0040438 (Phosphotyrosine protein) phosphatases II 8-149 1.7e-28 95.3 In-house 80-271 (317) alignment 
Range on Protein: 8-149
Range on HMM: 80-271/317.0
EISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDAT---------------------------------------------YDKAPVEKEGIHV
.. .....|..|  |.. |...| . ....|||..|.... .                                             .|. ...   .| 
dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhy

LDWPfDDGAPPPNQIVDDWLNLLKTKFReEPGCCVAVHCVAGLGRAPVLVALALI------ECGMKYEDAVQFIRQKRRGAF-NSKQLLYLEKY
..|| |.|.||  ... |.|........ .||..|.|||.||.||. ...|. |.      |.|. .|.||...|..|.||. .  |. .| ..
tgWp.dhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyda
0049260 (Phosphotyrosine protein) phosphatases II 9-149 3.9e-39 129.1 In-house 4-144 (152) alignment 
Range on Protein: 9-149
Range on HMM: 4-144/152.0
ISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCVAGLGRA
. . ...|..|. |.. ||..| . ||..|.||.|.... .... . ....|..| .|..|. .|.. .. ..|.|.  |.....|..|.|||.||.||.
gyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRt

PVLVALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLEKY
..|||. |...|...|.||...|.|| ||. ... |.. ..
gtlvaaylmllgvsleeavalvrekRpgavpnpgqlrflye
0043336 (Phosphotyrosine protein) phosphatases II 9-146 3.6e-30 100.8 In-house 83-269 (278) alignment 
Range on Protein: 9-146
Range on HMM: 83-269/278.0
ISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDAT--------------------------------------------YDKAPVEKEGIHVLD
    ...|..|  |.. |...| . ....||||.|.... .                                            .|. . .  ..| |.
gynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylg

WPfDDGAPPPNQIVDDWLNLLKTKFReEPGCCVAVHCVAGLGRAPVLVALALI------ECGMKYEDAVQFIRQKRRGAF-NSKQLLYL
|| |.|.|.. ... |.|. ......  .. .|.|||.||.||. ...|| |.      |.|. .|.||...|..| ||. .  |. .|
wp.dhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfl
0046845 (Phosphotyrosine protein) phosphatases II 9-142 6e-25 83.6 In-house 72-261 (284) alignment 
Range on Protein: 9-142
Range on HMM: 72-261/284.0
ISYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDAT-----------------------------------------------YDKAPVEKEGIH
..| ...|..|  |.. |...|   . ...|...| ... .                                               |.. ...   .|
ltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfh

VLDWPfDDGAPPPNQIVDDWLNLLKTKFRE-EPGCCVAVHCVAGLGRAPVLVALALIEC---------GMKYEDAVQFIRQKRRGAFNSKQ
...|| |.|.||  ... ..|.|... ... ..|. ..||| ||.||. ...|| |. .         |. ...||...|..| |.... .
ytswp.dhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle
0041856 (Phosphotyrosine protein) phosphatases II 10-158 2e-32 107.6 In-house 30-174 (182) alignment 
Range on Protein: 10-158
Range on HMM: 30-174/182.0
SYENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDGAPPPnqiVDDWLNLLKTKFReePGCCVAVHCVAGLGRAP
|. ..||..|. |.. |...| . ||..|.||.|....  |.   .|..||..|..|..|. .|.   .|..|.....  .  .|..|.||| ||.||..
slpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd...ldelldfieevle..eggpvlVHCsaGvgRtg

VLVALALIE-CGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKMRLRFR
.|||. |.. .|. .|.||...|..| |.. . . .... .   ..|...
tlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllk
0050432 (Phosphotyrosine protein) phosphatases II 10-143 1.7e-26 88.7 In-house 102-287 (308) alignment 
Range on Protein: 10-143
Range on HMM: 102-287/308.0
S--YENMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDK--------------APVEKEG----------------------------------
   . ...|..|  |.. |...|   . ...|.. |.... ....               ..| ..                                  
yssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvth

IHVLDWPfDDGAPPPNQIVDDWLNLLKTKFreePGCCVAVHCVAGLGRAPVLVALALI------ECGMKYEDAVQFIRQKRRGAFNSKQL
.| ..|| |.|.||  .|. |.|.|.....   ||. ..||| ||.||. ...|| |.      |.|. ...||...|..| |...... 
fhytnWp.dhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeq
0045098 (Phosphotyrosine protein) phosphatases II 11-156 1.3e-33 112.0 In-house 62-274 (278) alignment 
Range on Protein: 11-156
Range on HMM: 62-274/278.0
YeNMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYDK----------------------------------------------APVEKEGIHVLD
| ...|..|  |.. |...| . |...|.|..|.... ....                                              .  |. |...|.
y.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlh

W-PFDDGAPPPNQIVDDWLNLLKTKFR---------------EEPGCCVAVHCVAGLGRAPVLVALALIEC----GMKYEDAVQFIRQKRRG-AF-NSKQ
. |..|. .|.. |.. .|.||.   .               ...|..|.||| ||.||. .|||. |. .    |. ...||...|..|.| |. |  |
ylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleq

LLYLEKYRPKMRLR
. .|...  ...||
yrflyefllelllr
0039614 (Phosphotyrosine protein) phosphatases II 12-158 4.4e-31 103.9 In-house 88-293 (297) alignment 
Range on Protein: 12-158
Range on HMM: 88-293/297.0
E-----------NMRFLITHNPTNATLNKFTEELKKYGVTTLVRVCDATYD-----------------------------------------KAPVEKEG
            ...|..|  |.. |...| . ....|||..|.... ...                                         . . .   
inAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvth

IHVLDWPfDDGAPPPNQIVDDWLNLLKTKFREE-PGCCVAVHCVAGLGRAPVLVALALI------ECGMKYEDAVQFIRQKRRGAF-NSKQLLYLEKYRP
.....|| |.|.||  ......|.|... ..|  .|..|.|||.||.||. ...|. |.      |.|. ...||...|..|.||. .  |. .| ..  
fqytgwp.dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall

KMRLRFR
....|..
ellkrkl
0049772 (Phosphotyrosine protein) phosphatases II 14-150 1.3e-25 86.2 In-house 84-274 (314) alignment 
Range on Protein: 14-150
Range on HMM: 84-274/314.0
MRFLITHNPTNATLNKFTEEL------------KKYGVTTL------------------------------------------VrvcDATYDKAPVEKEG
..|..| .|.. |.. | ||              .. | ..                                              . .||.  .|..|
lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk...eelydpelferlg

IHVLDWPFDDGAPPPNQIVDDWLNLLKTKfreEPGCCVAVHCVAGLGRAP--VLVALALIECGMKYEDAVQFIRQKRR-----GAFNSKQLlYLEKYR
|..|..|..|| .|. ...|..|.....    ..| .|.||| || ||..  |..|. .. .|. .|.|....|.||      |.... .. |.....
ikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRpinpnpgfieqleq.yefile
0038934 (Phosphotyrosine protein) phosphatases II 15-144 1.3e-39 131.2 In-house 19-166 (194) alignment 
Range on Protein: 15-144
Range on HMM: 19-166/194.0
RFLITHNPTNATLNKFTEELKKYGVTTLVRVCD----------------ATYDKAPVEKEGIHVLDWPFDD-GAPPPNQIVDDWLNLLKTKFREEPGCCV
||.... |.. .|.|..|||.......|||...                 .||.  .|| ||..|..|| | |..|...|....|.|......| ||..|
rfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvv

AVHCVAGLGRAPVLVALALIE-CGMKYEDAVQFIRQKRRGAFNSKQLL
||||.|||||...||| .||. .||..|.|....|.||.||... . |
aVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyl
0046846 (Phosphotyrosine protein) phosphatases II 15-152 8.1e-34 112.2 In-house 24-171 (176) alignment 
Range on Protein: 15-152
Range on HMM: 24-171/176.0
RFLITHNPTNATLNKFTEELKKYGVTTLVRVCDA--------TYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEpgCCVAVHCVAGLG
|...|. |.. || .| |.||..|.|..|....         ...   .||.||..| .|..|. .|. ......|.....  .|    .|.|||.||.|
rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsaGig

RAPVLVALALIEC--GMKYEDAVQFIRQKRR-GAF-NSKQLLYLEKYRPK
|...|||. |.|.  |...|.|....|..|. ||. . .|. .|...  .
RtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
0037934 (Phosphotyrosine protein) phosphatases II 15-149 2.7e-26 88.0 In-house 45-237 (243) alignment 
Range on Protein: 15-149
Range on HMM: 45-237/243.0
RFLITHNPTNATLNK----FTEELKKYGVTTLVRVCDAT------------------------------------------YDKAPVEKEGIHVLDWPFD
|. .|  |.. |..     | . |...|.|..| ... .                                          .|  ......||.. .|. 
rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp

DGAPPP-NQIVDDWLNLLKTKFRE-------EPGCCVAVHCVAGLGRAPVLVALALIEC--GMKYEDAVQFIRQKRRG-AF-NSKQLLYLEKY
|. .|.  ... |.|. ...  .|        .|  |.|||.||.||. .|.|. |.    |. .|.||...|..| | |. .  |. .| ..
dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyea
0051429 (Phosphotyrosine protein) phosphatases II 15-149 6.5e-20 67.4 In-house 23-220 (272) alignment 
Range on Protein: 15-149
Range on HMM: 23-220/272.0
RFLITHNPTNATLNKFTEElKKYGVTTLVRVCDAT---YDKAPVEKEGIHVLDWPFDDGAPPPN------------------------------------
|.. . .|...| . |    |..|..| | ... .   ..| . . .||..| .|. | ..|.                                     
rlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsageare

----------------QIVDDWLNLLKTkfreepGCCVAVHCVAGLGRAPVLVALALIECGMK--------------YEDAVQFIRQKRRGAF-NSKQLL
                . . ..|.|| .      |  | ||| || .|  ..||| |.  |.               .|.||. .|..|.||. .  |.|
vmhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraqrpgavqteeqyl

YLEKY
.| ..
flyea
0051082 (Phosphotyrosine protein) phosphatases II 16-147 7.1e-27 89.3 In-house 15-145 (151) alignment 
Range on Protein: 16-147
Range on HMM: 15-145/151.0
FLITHNPTNatlnKFTEELKKYGVTTLVRVCDAT---YDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCVAGLGRAPVLV
....  |..     | |.||..|..| | ... .   |.. .....||.||..|..|  .|. ..  |... .  .... .. .|.||| ||.||  .||
lyrsggpla....dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlv

ALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYLE
|| |. .|. .|.|....|.|| |.....|  ...
alylmllgvsleealeeyrlkrpgvvqpnqqflfq
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 16-146 5.4e-07 23.4 In-house 150-280 (302) alignment 
Range on Protein: 16-146
Range on HMM: 150-280/302.0
FLITHNPTNATLNKFTEElKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPfDDGAPPPNqivDDWLNLLktKFREEPGCCVAVHCVAGLGRAPVLVALA
. ..    .  |..||.  |.. . |.    . . .| .   . ..   || | |||      .  |..|  || |     | ||| ||.||.  |||. 
ytvktvsvktdleeftdk.ksfklytveiknekkkkkvkktvdilafsawp.dhGapkea...ytaldil..kfcesykknvlvhcsaGvGrtGtlvaik

L-IECGM-----KYEDAVQFIRQKRRGAFNS-KQLLYL
  |.  .     .  . |. .|| | || .. .||.||
yGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_DSP15_pd Subfamily DSP15 26-137 6.2e-09 30.1 In-house 15-122 (151) alignment 
Range on Protein: 26-137
Range on HMM: 15-122/151.0
TLNKFTEELKKYGVTTLVRVCDatyDKAPVEKEgIHVLDWPFDDGAPP-PNQIVDDWLNLLKTKFREEPGCcvAVHCVAGLGRAPVLVALALIE-CGMKY
.  | .| ||.  .|... | |   .. .. |. |. .  . .| .    ......  ... .   .| ..   |||.||. |.  ||.. |.    ...
rdskdeelLkeknithilsvhd...nakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenv..lvhClaGvsRsvtlvvaYlmtvtelnw

EDAVQFIRQKRRGA
.||...|...|  |
rdalevikaaRsva
0044763 (Phosphotyrosine protein) phosphatases II 27-153 1.7e-30 101.4 In-house 37-170 (178) alignment 
Range on Protein: 27-153
Range on HMM: 37-170/178.0
LNKFTEELKKYGVTTLVRVCDATY------DKAPVEKEGIHVLDWPFDDGAPPP-NQIVDDWLNLLKTKFReEPGCCVAVHCVAGLGRAPVLVALALI-E
  .. | ||..|.|..|.... ..      |.  .|..||..| .|..|. .|.  ............    |.|..|.||| ||.||...|||. |. .
paddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkk

CGMKYEDAVQFIRQKRRGAFNSKQLLYLEKYRPKM
.|. .|.|....|..|..  |  || .|... ...
lglsleeaielvrerRpivpnpgqlrqLyefelrl
subfamily_CDC14_pd Subfamily CDC14 28-152 5.5e-20 66.5 In-house 202-322 (328) alignment 
Range on Protein: 28-152
Range on HMM: 202-322/328.0
NKFTEELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKfreepGCCVAVHCVAGLGRAPVLVALALI-ECGMKYEDA
.|. |  .|..|||.||.    ||.   ...|..  |  | ||. |...||  .|.....         .|||| |||||.  |.|  |. . ..  ..|
eklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka.....eGaiavhCkaGLGrtGtLiacylmkhyrftaaea

VQFIRQKRRGAFNSKQLLYLEKYRPK
. ..|  | |   ..|  .||. . .
iawlricrPGsvigpqqkfleekqaa
PTEN_1 29-152 1.2e-22 75.7 In-house 58-190 (196) alignment 
Range on Protein: 29-152
Range on HMM: 58-190/196.0
KFTEELKKYGVTTLVRVCD------ATYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEP-GCCVAVHCVAGLGRAPVLVALALIECG-
.. ..||. |.|..|....      ..||.   .|.|. .|. |..|  .|. . . |... ..   .. | | .|.||| |||||  ..||  |...| 
adldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk

MKYEDAVQFIRQKR-RGAFNSKQLLYLEKYRPK
. ...|....|.|| .||.|| ..  |..|  .
ltadeAlelvrekRppgapnspsqerlleyfae
subfamily_DSP11_pd Subfamily DSP11 29-135 2.5e-07 24.8 In-house 49-158 (178) alignment 
Range on Protein: 29-135
Range on HMM: 49-158/178.0
KFTEELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKF--REEPGCCVAVHCVAGLGRAPVLVALALIE-CGMKYED
| .|. || |.   .   |  |.|  ...||.. |         | ...|... . .|     ... .  ..|||  |. |.  |.   ||. .|.. ||
klqeknkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyeped

AVQFIRQKRR
|..   . | 
aieafeearG
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 29-117 9.2e-06 19.6 In-house 162-242 (305) alignment 
Range on Protein: 29-117
Range on HMM: 162-242/305.0
KFTEELKKYGVTTLVRVCDATYDKAPVekEGIHVLDWPfDDGAPPPNQIVddwLNLLKtKFREEPGCcVAVHCVAGLGRAPVLVALALI
||... |     | . .  .  ..  |     |  ||| | | |. .. .   |.||. | |   |  ..||| ||.||.  .| |  |
kfrkdakakvtetvlviegpgekarkv..thyhwidwp.drgvpaadlai...lelle.karpskgp.ivvhcsagigrtgsvvmleyi
0048179 (Phosphotyrosine protein) phosphatases II 31-151 1.2e-25 85.3 In-house 22-142 (144) alignment 
Range on Protein: 31-151
Range on HMM: 22-142/144.0
TEELKKYGVTTLVRVCDaTYDKAPVEKEGIHVLDWPFDDGAPPPN-QIVDDWLNLLKTKFReePGCCVAVHCVAGLGRAPVLVALALI-ECGMKYEDAVQ
 |.|||.|.||...... .|... .|.|||..| .|..|  .|.  ......|.....  .  .|..|.||| ||.||...|||. |. ..|. .|.|..
lellkklgittvinlte.eyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmkklglsleeala

FIRQKRRGAF-NSKQLLYLEKYRP
..|..| ||. |  || .|..|..
lvrsrrpgavpnpgqlrfLleyek
0048076 (Phosphotyrosine protein) phosphatases II 31-151 6e-25 83.0 In-house 22-140 (145) alignment 
Range on Protein: 31-151
Range on HMM: 22-140/145.0
TEELKKYGVTTLVRVcdaTYDKAPVEKEGIHVLDWPFDDGAPPPN-QIVDDWLNLLKTKFREePgCCVAVHCVAGLGRAPVLVALALIEC-GMKYEDAVQ
 |.||..|.||....   |...  .|..||..| .|..|  .|.  ......|.....  .| . ..|.||| ||.||...|||. |. . |. .|.|..
lellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealke.g.gpvlVHCsaGvgRtgtlvaaylmlllgvsleeale

FIRQKRRGAF-NSKQLLYLEKYRP
..|..|.||. |  || .|...  
lvrsqrpgavpnpgqlrflyefel
PTPc_motif_SM00404 32-139 4e-10 34.7 In-house 21-125 (140) alignment 
Range on Protein: 32-139
Range on HMM: 21-125/140.0
EELKKYGVTTLVRVCDATYDKapVEKEGIHVLDWPFDD-GAPPPNQIVDDWLNLLKTKfrEEPGCCVAVHCVAGLGRAPVLVALALIE-CGMKYEDAVQF
. |||.|.|. . | .    .   |..|...|  | || .  .  .  |  |. ...   |. |. | ||| ||. |   |..  |..  ......|..|
allkklgithvinvteevslt..kensgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayef

IRQKRrGAFN
....|  ...
vkerR.piis
DSPc Dual specificity phosphatase, catalytic domain 32-139 5.7e-10 34.2 Pfam-A 12-118 (133) alignment 
Range on Protein: 32-139
Range on HMM: 12-118/133.0
EELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDgapPPNQIVDDWLNLLKTK--FREEPGCCVAVHCVAGLGRAPVLVALALIE-CGMKYEDAVQ
. |.|.|.|  . | . .  .   .|. |. |. | .|     .. . ..|. ...     |. |. |.||| ||. | . |..  |..  ......|..
alleklgitlvinvtkevpnnnaikkseieylripved...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAye

FIRQKRrGAFN
|....| ....
fvkerr.skis
DSPc Dual specificity phosphatase, catalytic domain 32-139 5.7e-10 34.2 In-house 12-118 (133) alignment 
Range on Protein: 32-139
Range on HMM: 12-118/133.0
EELKKYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFDDgapPPNQIVDDWLNLLKTK--FREEPGCCVAVHCVAGLGRAPVLVALALIE-CGMKYEDAVQ
. |.|.|.|  . | . .  .   .|. |. |. | .|     .. . ..|. ...     |. |. |.||| ||. | . |..  |..  ......|..
alleklgitlvinvtkevpnnnaikkseieylripved...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAye

FIRQKRrGAFN
|....| ....
fvkerr.skis
subfamily_CDKN3_pd Subfamily CDKN3 33-153 6.9e-09 29.6 In-house 82-195 (202) alignment 
Range on Protein: 33-153
Range on HMM: 82-195/202.0
ELKKYGVTTLVRVcdatYDKApvekeGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGccVAVHCVAGLGRAPVLVALAL--IECGMKYEDAVQFI
||.|| |  |.      | .|     |. |  .|. ||  |      . |. |.. ...  .    |||  ||||. ...|  |  ..  ....||.. .
elskyrvrrlldl....yqqa.....glivhhypiadglvpdiasclkileelrinlkayrk..tlvhcygglgrsslviaclllylddtiepkdaidkl

RQKRR-GAF-NSKQLLYLEKYRPKM
|. .  .|    ||  ||...| |.
rdlkgsraiqtvkqynylsefrdkl
subfamily_DSP1_pd Subfamily DSP1 33-135 1.6e-06 22.3 In-house 38-137 (163) alignment 
Range on Protein: 33-135
Range on HMM: 38-137/163.0
ELKKYGVTTLVRV---CDATYDKaPVEKEGIHVLDWPFDDGAPPPNQIVdDWLNLLKTKfreepGCCVAVHCVAGLGRAPVLVALALIE-CGMKYEDAVQ
 ||. |.| .. |   .| ....   | . ... | | .|     .... ....  |.|     .  | .|| ||. |.  |. . |..   ...|.| .
iLkslgitailnvskeldnvfed.lfeYkklkleDspkadislvfeevi.efidevkkk.....nGkvlihCqaGisRsstlclaylmktkrvsleeafd

FIRQKRR
|..|.| 
fvkqrRs
subfamily_DSP19_pd Subfamily DSP19 33-136 3.1e-06 21.6 In-house 32-132 (152) alignment 
Range on Protein: 33-136
Range on HMM: 32-132/152.0
ELKKYGVTTLVRVCDATYDK--APVEKEGIHVLDWPFDDGApppnQIVDDWLNLLKTKFREEpgCCVAVHCVAGLGRAP-VLVALALIECGMKYEDAVQF
.||. ..| .. |   . .     ..   |..|| |  |      .. .. |. ..   ...   .| ||| ||  |.. | .|  . .  ...|.|.. 
ilkekkitHilnvatgvpnvfpkdftylsieilDlpetdll....sylkealdFieearskd..gavlvHCnAGvSRsasvviaylmkkeelsleealel

IRQKRRG
.|..|. 
vrearpc
subfamily_PTPRA_pd Subfamily PTPRA 34-128 5.2e-06 20.6 In-house 168-262 (330) alignment 
Range on Protein: 34-128
Range on HMM: 168-262/330.0
LKKYGVTTLV--RVCDATYDKAPVEKEGIHVLDWPfDDGAPPPNQIVDDWLNLLKTKFREEPGcCVAVHCVAGLGRAPVLVALALIECGMKYEDAVQ
|..| |  ..  .. ||| .|..   . .|   || | | |   . . . |. .|.. . . |  . ||| || ||.  ...|  .   .| |  | 
lvdytvrkflvqqlpdatrekksrlvrqfhftswP.dvGvPfepiGmlkllkkvkklnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvd
subfamily_RNGTT_pd Subfamily RNGTT 36-159 1.3e-09 32.0 In-house 54-173 (189) alignment 
Range on Protein: 36-159
Range on HMM: 54-173/189.0
KYGVTTLVRVCDATYDKAPVEKEGIHVLDWPFD-DGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCVAGLGRAPVLVALALIEC-GMKYEDAVQFIRQK
| |.   .   .  |||  .|||||.         |. | .. |. . .|... |...| . ..|||  |  |.  |..  |.|   .. |.||.  .. 
klglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFaka

RRGAfnskqlLYLEKYRPKMRLRFRD
|         .| |.|. ..  |. |
RppG......iykedylkellrrYad
subfamily_DSP23_pd Subfamily DSP23 38-139 8.6e-09 30.2 In-house 31-130 (148) alignment 
Range on Protein: 38-139
Range on HMM: 31-130/148.0
GVTTLVRVCDATydKAPVE-KEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTkfREEPGCCVAVHCVAGLGRAPVLVALALIE-CGMKYEDAVQFIRQKRR
||  || . . .  . .||   .. .     ||  ||  . |........    || .  |.|||. | ||.  ..|  |.   ..   .|.  .|..| 
gvrylvslteeg..rphveatpnltlvrlriddyhppaleqvvefvrvvee..aeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrp

GAFN
|. .
gsve
0048567 (Phosphotyrosine protein) phosphatases II 41-148 1.5e-13 45.4 In-house 19-132 (157) alignment 
Range on Protein: 41-148
Range on HMM: 19-132/157.0
TLVRVCDATYDKAPV-EKEGIHVLDWPFDDGaPPPNQIVDDWLNLLKTKFR--EEPGCCVAVHCVAGL---GRAPVLVAL-ALIECGMKYEDAVQFIRQK
.|.|. . .|.  .    .|.. .|. ||.| |..  |. .. ..|. ...  |. |. .|||| |||   ||. .|... ... .|.  |.|....|. 
llprlpkslynalyFsiddglvyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplriv

RRGAFNSKQLLYLEK
| |     .  ||. 
rpgsvpfrdasylls
subfamily_PTPN12_pd Subfamily PTPN12 43-125 2.8e-06 21.5 In-house 158-238 (290) alignment 
Range on Protein: 43-125
Range on HMM: 158-238/290.0
VRVCDATYDKAPVEKEGIHVLDWPfDDGAPPPNQIVDDWLNLLKtKFREEPGCCVAVHCVAGLGRAPVLVALALIECGMKYED
.|   .. .|.  . . .|  .|| | | |   . . . ..|.. ...|.    ..||| || ||. ...|. ..   .| | 
irtLkveaqkesrkvyqfhYtaWP.DhgvPssaksllelielvr.elqesedaPlvvhCsaGvGrtGtiiaidyvrellkaek
subfamily_PTEN_pd Subfamily PTEN 45-135 1.6e-10 36.3 In-house 68-157 (184) alignment 
Range on Protein: 45-135
Range on HMM: 68-157/184.0
VCDATYDKAPVekeGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEPGCCVAVHCVAGLGRAPVLVALALIECGMKY--EDAVQFIRQKRR
  . .||.. .     .|  .||||  ||| ..... .. ... . |..   |.||| || ||. ||..  |.....    |.|...  ..| 
rserkydskkf...dgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRt
subfamily_PTPDC1_pd Subfamily PTPDC1 49-144 8.7e-12 39.8 In-house 72-165 (182) alignment 
Range on Protein: 49-144
Range on HMM: 72-165/182.0
TYDKAPVEKEGIHVLDWPFDDGAPPPNQIVDDWLNLLKTKFREEpgcCVAVHCVAGLGRAPVLVALALI-ECGMKYEDAVQFIRQKRRGAFNSKQLL
.||.  . ..|| |  ....|   .. . . |   ...   .|.    ||||| |||||. ||.|  |.    .. |.|....|.||  . .... .
sYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqv
subfamily_PTPMT1_pd Subfamily PTPMT1 55-150 1.1e-08 29.7 In-house 69-165 (171) alignment 
Range on Protein: 55-150
Range on HMM: 69-165/171.0
VEKEGIHVLDWPFDDGA-PPPNQIVDDWLNLLKTKfrEEPGCCVAVHCVAGLGRAPVLVALALI-ECGMKYEDAVQFIRQKRRG-AFNSKQLLYLEKYR
 .|.|.. |  .  | .  |  . . . .....     . | .| ||| || ||.  |||  |. .  .. |.|......||.    ..||.  |..|.
wkklgveqlqlatvDfteapdleklekgvefiekv..askgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeye
Y_phosphatase Protein-tyrosine phosphatase 58-143 1.7e-10 36.1 Pfam-A 136-226 (235) alignment 
Range on Protein: 58-143
Range on HMM: 136-226/235.0
EGIHVLDWPfDDGAPP-PNQIVddwlNLLKT----KfrEEPGCCVAVHCVAGLGRAPVLVALALIECGMKY------EDAVQFIRQKRRGAFNSKQ-L
. .|. .|| | |.|  |....    .|..     |  |.    | ||| || ||. ..||| .. . ..        ..|. .|..|.|...| . .
kqlhytnWp.dhgvpespksll....dlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqY
Y_phosphatase Protein-tyrosine phosphatase 58-143 1.7e-10 36.1 In-house 136-226 (235) alignment 
Range on Protein: 58-143
Range on HMM: 136-226/235.0
EGIHVLDWPfDDGAPP-PNQIVddwlNLLKT----KfrEEPGCCVAVHCVAGLGRAPVLVALALIECGMKY------EDAVQFIRQKRRGAFNSKQ-L
. .|. .|| | |.|  |....    .|..     |  |.    | ||| || ||. ..||| .. . ..        ..|. .|..|.|...| . .
kqlhytnWp.dhgvpespksll....dlirkveksk..eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqY
subfamily_PTPN13_pd Subfamily PTPN13 58-142 2.3e-06 22.1 In-house 169-256 (273) alignment 
Range on Protein: 58-142
Range on HMM: 169-256/273.0
EGIHVLDWPFDDGAPPPNQIVDdWLNLLKtKFREePGCCVAVHCVAGLGRAPVLVALA----LIE--CGMKYEDAVQFIRQKRRGAFNSKQ
  ..  .||  .    .....   .  .. ....     ..||| ||.||. .|...     |||    .. .. |. .|..|.|   .|.
ahlnfvkwPdhgvPssaaellq.fvaevr.rlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkd
PTPc_DSPc_SM00012 60-142 5.1e-11 38.1 In-house 5-94 (105) alignment 
Range on Protein: 60-142
Range on HMM: 5-94/105.0
IHVLDWPFDdGAPPPNQIVDDWLNLLKTKFREEP-GCCVAVHCVAGLGRAPVLVALALIECGMKYE-------DAVQFIRQKRRGAFNSKQ
.|...||   |.| . . . ..|. .|.. ...  .  | ||| || ||. ..|||... . ...|       . |. .|..|.|......
yhytgwpdh.gvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqtee
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 60-129 5.8e-06 20.6 In-house 182-252 (297) alignment 
Range on Protein: 60-129
Range on HMM: 182-252/297.0
IHVLDWPFDDGAP-PPNQIVDDWLNLLKTKFREEPGCCVAVHCVAGLGRAPVLVALALIECGMKYEDAVQF
 . ..|| ..       . . .... .. .| ..  . . |||.||.||. ||...  . . .| |..|. 
yqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdi
subfamily_PTPRB_pd Subfamily PTPRB 60-129 6.7e-06 20.4 In-house 184-253 (293) alignment 
Range on Protein: 60-129
Range on HMM: 184-253/293.0
IHVLDWPfDDGAPPPNQIVDDWLNLLKTKF-REEPGCCVAVHCVAGLGRAPVLVALALIECGMKYEDAVQF
 | . || | | |   . . |... ....  ...    . ||| ||.||. ...||  .   .. || |. 
yhftsWp.dhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdi
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 64-134 7.9e-06 20.1 In-house 185-256 (307) alignment 
Range on Protein: 64-134
Range on HMM: 185-256/307.0
DWPfDDGAPPPNQIVddwLNLLKTKFRE-EPgccVAVHCVAGLGRAPVLVALALIECGM-------KYEDAVQFIRQKR
.|| | |.|. |      .|||..   . .|   | ||| ||.||.  .||..|.   |       . .. |. .|..|
nwp.drgvpqinlta...inlleavrydtnp...vvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqr
subfamily_DSP8_pd Subfamily DSP8 88-147 7.9e-07 22.8 In-house 88-145 (159) alignment 
Range on Protein: 88-147
Range on HMM: 88-145/159.0
KFREEpGCCVAVHCVAGLGRAP-VLVALALIECGMKYEDAVQFIRQKRrgAFNSKQLLYLE
| ..|  ..| ||. ||  |.. | .|  . .  |....| .|...||  .  |..| .|.
kakse.ngrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekr..ptispnlnflg
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 91-139 9.9e-07 22.0 In-house 77-126 (145) alignment 
Range on Protein: 91-139
Range on HMM: 77-126/145.0
EEPGCCVAVHCVAGLGRA-PVLVALALIECGMKYEDAVQFIRQKRRGAFN
 | |  | |||.||. |.  | ||. .  |.|   .| . .| .|  |. 
keegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrllayp
subfamily_Slingshot_pd Subfamily Slingshot 92-136 7.5e-06 19.4 In-house 94-139 (169) alignment 
Range on Protein: 92-136
Range on HMM: 94-139/169.0
EPGCCVAVHCVAGLGR-APVLVALALIECGMKYEDAVQFIRQKRRG
. |  | |||  |. | | ...| |. | |...|.|.......|. 
kkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsv
subfamily_DSP3_pd Subfamily DSP3 93-146 7.4e-07 22.9 In-house 96-150 (162) alignment 
Range on Protein: 93-146
Range on HMM: 96-150/162.0
PGCCVAVHCVAGLGRAPVLV-ALALIECGMKYEDAVQFIRQKRRGAFNSKQLLYL
.   | ||||.|. |...|| |  .|   |.  .|.. .|.||.   |.  |  |
kegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReilPneGFlkqL