Gene SSH2 in Homo sapiens

Synonym: SSH-2, SSH-2L, SSH2

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily Slingshot
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP042_AA protein Get Run
HsapP042_AA_332-477 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_LRR-DSP_pd Subfamily LRR-DSP 250-473 4.2e-29 95.4 In-house 36-258 (263) alignment 
Range on Protein: 250-473
Range on HMM: 36-258/263.0
WNAMQDVQSHRPDSPALFTDIPTERERTERLIKTKLREIMMQKDLENITS---KEIRTELEMQMVCNLREFKEFidnEMIVILgQMDSPTQIFEHVFLGS
 |. ....|   ||     .   . .  .   | .. |..   .||       ||.    . ....   |.|.    | ...| .   | .| ...|||.
intcnninsnnndsnnsnnnnnnnndnnnncnknnileminsteleggglgclkelnirdnrelislpveykqv...eslitl.vssvPdeiidklflGg

EWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNI-RVYDEEATDLLAYWNDTYKFISKAKKHGSkCLVHCKMGVSRSASTVIAYAMKEYGWNLDRA
   | |   |.. || .||    ... .|| .| |  |  . | .  |.  ....|  || . .|.|   ||||. |||||.. ||.| ||    .. .|
ldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvisylmkkqrlkfkea

YDYVKERRTVTKPNPSFMRQLEEYQGIL
.| |...|.  .||| |. ||  |.  |
ldlvikkrpriqPnpGfkdqlkkyekkl
DEK_C DEK C terminal domain 277-329 3.9e-18 54.6 Pfam-A 1-53 (54) alignment 
Range on Protein: 277-329
Range on HMM: 1-53/54.0
TERLIKTKLREIMMQKDLENITSKEIRTELEMQMVCNLREFKEFIDNEMIVIL
|.. ||...|||... |||..|.|..|.||| .. ..| |.|.||....  .|
tdeeikeevreiLkeaDLetvTkkqvrkeLearlgvdLserKafIkdlieefL
0049772 (Phosphotyrosine protein) phosphatases II 281-485 2.3e-38 128.1 In-house 80-285 (314) alignment 
Range on Protein: 281-485
Range on HMM: 80-285/314.0
IKTKLREIMMQKDlENITSKEIRTelEMQMVCNLREFK--EFIDNEMIVI---------------------LGQMDSPTqifehvflgSEWNASNLEDLQ
... |. | .|.   .||   .|.  |... .| ...   . ..  .||.                     | ..| ..         .|..|..||.|.
vdgflkfIatqgp.leitvvdfre..epvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.........neptaadlellk

nrgvryilnvtREI--DNFFPGV-FEYHNIRVYDeEATDLLAYWNDTYKFISKAkKHGSKCLVHCKMGVSRSAS-TVIAYAMKEYGWNLDRAYDYVKERR
           .|.  ...|..  ..|..| |.| . ..||..... ..|| .| . |.. |||||.|..|...  |.|| || .|..|. |...|...|
...........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkR

TvTKPNPSFMRQLEEYQGILLASKQRHNKLWR
.  .|||.|..|||.|. || |.... ..|..
p.inpnpgfieqleqyefilealleylkflkk
subfamily_PTPMT1_pd Subfamily PTPMT1 315-472 2.3e-15 51.4 In-house 17-167 (171) alignment 
Range on Protein: 315-472
Range on HMM: 17-167/171.0
REFKEFIDNEmiVILGQMDSPTQIfEHVFlGSEWNASNLEDLQNRGVRYILNVTREIDNFfpgVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSK
|.. . ||.   ||||..    .| ....  .|  .. .   ..  .. . | |.|  .      |. .... |   .  |.  ... .||.| ...|..
rnwydriDdt..vilGalPfrsli.keLi.ekenvkavvslneeyelkalansteewkkl...gveqlqlatvDfteapdleklekgvefiekvaskgkr

CLVHCKMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGI
  |||| | .|||. |..| ||.. .... | ...|..|  .. .   ...|.||.  
vYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyeek
subfamily_Slingshot_pd Subfamily Slingshot 317-485 2.6e-98 320.3 In-house 1-169 (169) alignment 
Range on Protein: 317-485
Range on HMM: 1-169/169.0
FKEFIDNEMIVILGQMDSPTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCL
.||||||||.|||||.||...||.||.|||||||||||.|...||.||||||.|||||||..|||.||||||||.||||.|||.|||||.||||.|||.|
ykefidnemlvilgqldsaskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvl

VHCKMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILLASKQRHNKLWR
|||||||||||||||||||||||..|..|..||||||.|.|||..|..|||||.||| |||||||||.|
vhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileaskqrhnklfr
0044763 (Phosphotyrosine protein) phosphatases II 322-475 6.2e-41 135.3 In-house 10-172 (178) alignment 
Range on Protein: 322-475
Range on HMM: 10-172/178.0
DNEMIVILGQMDSPTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGV---------FEYHNIRVYDEEATDLLAYWNDTYKFISKAK-KH
.| . .  ...  ...|.....||| ..|..|| |.. |...|.|.| |. ..|..          ..|..| . |  ..|||... ....|| .|  ..
snleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdek

GSKCLVHCKMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERRTvTKPNPSFMRQLEEYQGILLA
|...||||..||.||.. |.|| ||..|..|. |...|.|||    |||...|||.|.. .||.
ggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
0046846 (Phosphotyrosine protein) phosphatases II 329-473 7.1e-28 92.9 In-house 6-172 (176) alignment 
Range on Protein: 329-473
Range on HMM: 6-172/176.0
LGQMDSPTQIFEHVFLGSEW----------NASNLEDLQNRGVRYILNVTREIDNFFPG-----------VFEYHNIRVYDEEATDLlAYWNDTYKFISK
||   ....| ....||| .           |..|| |.. |.....|.| |..  . .            ..|... . |  . || ... . ..|| .
lgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefire

AKKHGSKCLVHCKMGVSRSASTVIAYAMKE-YGWNLDRAYDYVKERRT-VTKPNPSFMRQLEEYQGIL
| |.| . ||||..|..|..  |.|| ..  .|.... |...|.|.|     ..|...|.|.|.   |
alkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0045098 (Phosphotyrosine protein) phosphatases II 332-473 1.3e-26 89.0 In-house 19-271 (278) alignment 
Range on Protein: 332-473
Range on HMM: 19-271/278.0
MDSPTQIFEHVFLGSEW-----------------------------------------NASNLEDLQNRGVRYILNVTREIDN-----------------
. .| .|.....||. .                                          |.... |.. |...|...|.....                 
lgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggslty

-----------------------------------FFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKK--------------HGSKCLVHCKMGVS
                                   ..  .. |...  ..   ...|... . ..|| .| |              .| ..||||..||.
gdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvg

RSASTVIAYAMKEY---GWNLDRAYDYVKERRTV-TKPNPSFMRQLEEYQGIL
|..  |.|| |.|.   |..|. |.......|     .|....|.|.|..  |
RtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_DSP6_pd Subfamily DSP6 333-473 1.1e-39 129.5 In-house 12-154 (158) alignment 
Range on Protein: 333-473
Range on HMM: 12-154/158.0
DSPTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFP--GVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTV
  | .| ....|||. .||||| |.. ...|.|||| ...|.|   | ..| .| . |.  ..| ... .. .|| .|... ||.||||  |.|||   .
efpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvt

IAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGIL
.|| ||..   |. |||.||.|..   || .|| || ...  |
laylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
subfamily_DSP8_pd Subfamily DSP8 333-473 1.4e-32 106.4 In-house 13-154 (159) alignment 
Range on Protein: 333-473
Range on HMM: 13-154/159.0
DSPTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTRE-IDN-FFPGVFeYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTV
. ||.| ....|||. .. . | |.. |. |.||. .. ..  ... .  .. . | |.   .|| ... ...|| |||.. ...|||.  | ||||. .
vgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkesk.flrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatva

IAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGIL
||| ||.   .|| || .|||.|.. .||  |. || ||.  |
iayimktlemsldeayrfvkekrptispnlnflgqLleyekel
PTEN_1 333-477 4.6e-27 90.1 In-house 37-195 (196) alignment 
Range on Protein: 333-477
Range on HMM: 37-195/196.0
DSP--TQIFEHVFLGSEWNA-SNLEDLQNRGVRYILNVTREIDN---------FFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKK--HGSKCLVH
. |   .|.|....||.  . ..|..|. .|.. ..|.. | ..         || . .||... . |  | .|   .   ..||. ...  .| ..|||
srpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVH

CKMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILLASK
|| |..||.  |.|| |. .... | | ..|.|.|..  ||......|.||.  |||.|
CkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellaek
subfamily_DSP1_pd Subfamily DSP1 334-476 7.5e-45 146.9 In-house 16-159 (163) alignment 
Range on Protein: 334-476
Range on HMM: 16-159/163.0
SPTQ-IFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIA
 |.. | ....|||| .||||| |.. |.  ||||..|.||.|. .|||... . |..  |. .....  .|| ..||.. | |.||..|.|||.. ..|
dPvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla

YAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILLAS
| ||.  ..|. |.|.||.||.. .|| .|..|| .|.  ||..
ylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkllle
subfamily_DSP14_pd Subfamily DSP14 334-473 9.1e-35 113.9 In-house 6-144 (157) alignment 
Range on Protein: 334-473
Range on HMM: 6-144/157.0
SPTQIFEHVFLGsEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAY
. .|| .. ||.    |.. | |.....  |.|||.|. |     .|. ...| |.....| .... ... | ..||.| |.||||..||||||| ..||
alsqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclay

AMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGIL
 ||    .|  || .||..| . .||  | .|| .|   |
lmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkkl
0041856 (Phosphotyrosine protein) phosphatases II 334-473 4.5e-32 106.5 In-house 18-172 (182) alignment 
Range on Protein: 334-473
Range on HMM: 18-172/182.0
SPTQIFEHVFLGSEWN--------------ASNLEDLQNRGVRYILNVTREI---DNFFPGVFEYHNIRVYDEEATDllayWNDTYKFISKAKKHGSKCL
 ...| ....||| ..              |..|. |...|...|.|.| |    ...   ...|... . | ...|    ......|| .....| ..|
dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd....ldelldfieevleeggpvl

VHCKMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERRT--VTKPNPSFMRQLEEYQGIL
|||..||.|... |.|| ||..|..|. |...|..||   |. ||  |..|| ... .|
VHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
0043147 (Phosphotyrosine protein) phosphatases II 334-477 7.4e-32 105.8 In-house 18-164 (172) alignment 
Range on Protein: 334-477
Range on HMM: 18-164/172.0
SPTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTRE---IDNFFPGVFEYHNIRVYDEEATdLLAYWNDTYKFISK--AKKHGSKCLVHCKMGVSRSAS
 |.... . .....  |.... |...|...|.|.|..    ..... ...|. . ..|  .. ||... ....|| .  |.. | ..||||..||.|.. 
ipdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgt

TVIAYAMKeYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILLASK
 |.|| |. .|..|. |...|.|.|    .|||..|.| ... .||  |
lvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfeklllllk
subfamily_DSP10_pd Subfamily DSP10 335-474 1.2e-40 133.0 In-house 14-154 (159) alignment 
Range on Protein: 335-474
Range on HMM: 14-154/159.0
PTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPG-VFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAY
 .|.. ..||||| .|..|. |.. .. ..|||| .. |.| .  ..|. | | | .  .|  |... ..|| .|.|.||. ||||. |.||||. ||||
asqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaY

AMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILL
 ||. . .|  ||..|||.|..  || .|| || |.   | 
lmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekeln
0048076 (Phosphotyrosine protein) phosphatases II 335-473 2.8e-38 126.1 In-house 4-142 (145) alignment 
Range on Protein: 335-473
Range on HMM: 4-142/145.0
PTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYA
|..|.....||| ..|..|| |.. |....||.|.|...... ...|... . | .. |||... . ..|| .| |.| ..||||..||.|... |.|| 
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaayl

MKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGIL
|...|..|. |...|...|    |||...|.|.|.. .|
mlllgvsleealelvrsqrpgavpnpgqlrflyefelel
PTPc_motif_SM00404 335-470 4e-38 125.5 In-house 2-138 (140) alignment 
Range on Protein: 335-470
Range on HMM: 2-138/140.0
PTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDN-FFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAY
|..| .|..|||. .|.|.. |.. |.....|||.|...      |.. .| . |.| ..|..|.. ...||..|.| | |.||||..||||||. .|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

AMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ
 |......|. ||..|||||   .|| .|.||| ||.
lmryrqlslaeayefvkerRpiispnlnfvrqLieye
0048179 (Phosphotyrosine protein) phosphatases II 335-472 4.8e-37 122.2 In-house 4-143 (144) alignment 
Range on Protein: 335-472
Range on HMM: 4-143/144.0
PTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVF--EYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIA
|..|.....||| . |..|| |.. |.....|.| | .. |....  .|... . | .. |||........|| .| ..| ..||||..||.|... |.|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGI
| ||..|..|. |...|..||    |||...|.|.||. .
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
0049260 (Phosphotyrosine protein) phosphatases II 335-472 1.5e-27 91.6 In-house 8-148 (152) alignment 
Range on Protein: 335-472
Range on HMM: 8-148/152.0
PTQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDN---FFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISK-AKKHGSKCLVHCKMGVSRSASTV
|...  . ..|... |.... |.. |...|...|.. ..   ...  ..|... . |  . ||  .  . ..|| | |.. | ..||||. ||.|..  |
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlv

IAYAMKeYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGI
.|| |. .|..|. |...|.|.| .  |||...|.| |....
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekl
0037934 (Phosphotyrosine protein) phosphatases II 335-470 7.2e-26 86.6 In-house 39-238 (243) alignment 
Range on Protein: 335-470
Range on HMM: 39-238/243.0
PTQIFEHVFLGSE--------WNASNLEDLQNRGVRYILNVTREI---------------------------------------------DNFFPGVFEY
 ...........         . ||... |.. |...|...|...                                             |...  |. |
liyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

HNIRVYD----EEATDLLAYWNDTYKFISK-----AKKHGSKCLVHCKMGVSRSASTVIAYAMKEY-GWNLDRAYDYVKERRTV-TKPNPSFMRQLEEYQ
| . . |    .. .|||........||..     | ..|...||||..||.|..  ..|| |... |..|. |.....|.|     ..||..|.| |. 
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal
subfamily_DSP12_pd Subfamily DSP12 336-474 1.3e-33 110.6 In-house 3-144 (155) alignment 
Range on Protein: 336-474
Range on HMM: 3-144/155.0
TQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTRE-ID--NFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIA
..| . ..||.  .. . | |.. ..  .| |..| ..  .  .|  .. .| ..||. .|.| . ... .||..| ... . ||||..|||||...|||
srilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

YAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILL
| ||.....|..|.. ||| .  ..|| .|..||  .. .  
YlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgc
0036282 (Phosphotyrosine protein) phosphatases II 336-470 4.9e-25 83.6 In-house 13-166 (174) alignment 
Range on Protein: 336-470
Range on HMM: 13-166/174.0
TQIFEHVFLGSEWNAsNLEDLQNRGVRYILNVTREI---------------DNFFPGVFEYHNIRVYDEEATDLLAyWNDTYKFISKAKKH--GSKCLVH
. | .....|.   | ..| |.. |.........|.               . . . ...|. . . | .. ||   . . .||. .| ..  | ..|||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CKMGVSRSASTVIAYAMKEYGW-NLDRAYDYVKERR---TVTKPNPSFMRQLEEYQ
|..||.|..  |.|| |. ... .|. |.|.|.|.|       ..||..|.| ...
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfe
0051082 (Phosphotyrosine protein) phosphatases II 336-469 3.2e-22 74.2 In-house 9-149 (151) alignment 
Range on Protein: 336-469
Range on HMM: 9-149/151.0
TQIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREI-----DNFFPG-VFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKH-GSKCLVHCKMGVSRSAS
... .......   | .|| |.. |...|.|.. |       ...|   .|...| . |  ...|  ...   .|.... .. . ..||||..|..|.. 
syvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

TVIAYAMKeYGWNLDRAYDYVKERRT-VTKPNPSFMRQLEEY
 |..| |. .|..|. |.......|. |. ||  |. || ..
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
subfamily_DSP19_pd Subfamily DSP19 337-472 7.8e-39 127.4 In-house 14-149 (152) alignment 
Range on Protein: 337-472
Range on HMM: 14-149/152.0
QIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMK
.. ....|||   |.. | |..... .||||. ...|.||  |.| .| ..|.. ||||.|.... .|| .|...    ||||. ||||||| |||| ||
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmk

EYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGI
.   .| .|...|.| |   |||  |..||.||.  
keelsleealelvrearpcikPneGFikqLkeyeae
subfamily_DSP15_pd Subfamily DSP15 337-477 1.1e-26 87.7 In-house 4-143 (151) alignment 
Range on Protein: 337-477
Range on HMM: 4-143/151.0
QIFEHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGvFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMK
.. . ..||   .... | |... .  ||.|  .  ....  .||. |.. |   ..|  . ... .|| |.. .. ..|||| .|||||.  |.|| | 
kvlpglylgnfrdskdeelLkeknithilsvhdnakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmt

EYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILLASK
    |   | . .|..|.| .||  | |||.||.   |.  
vtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkey
subfamily_DSP3_pd Subfamily DSP3 337-471 3.9e-26 85.6 In-house 13-155 (162) alignment 
Range on Protein: 337-471
Range on HMM: 13-155/162.0
QIFEHVFLGSEWNASNLEDLQNRGVRYILNVTRE----I---DNFFPG-VFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKH-GSKCLVHCKMGVSRSA
........| |  |.. . |.. |. ..|| ..     .   ..|. .  ..|. . | |  ..|| .|.. . ||| .| ..  .| ||||..||||||
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

STVIAYAMKEYGWNLDRAYDYVKERRTVTkPNPSFMRQLEEYQG
  |.|| |     .|  |   |...|... ||  |..|| |.. 
tlvlayLmirrkmtlveairtvrkkReil.PneGFlkqLaelde
0042113 (Phosphotyrosine protein) phosphatases II 337-469 8.1e-22 73.3 In-house 49-238 (245) alignment 
Range on Protein: 337-469
Range on HMM: 49-238/245.0
QIFEHVFLGSEWNASNLE----DLQNRGVRYILNVTREI----------------------------------------------DNFFPGVFEYHNIRV
.| .......   ....|     |.. |...|...|.|                                               |..   |. || . .
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

YDEEATDLLAYWNDTYKFISKAKK--HGSKCLVHCKMGVSRSASTVIAYAM-----KEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEY
 |  ..|||..  | ..|. || .   . ..||||..||.|..  ..|| |     ||.|..|. |.......|    ..||..|.| |.
pdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyea
subfamily_STYX_pd Subfamily STYX 338-478 6.3e-25 81.2 In-house 15-162 (166) alignment 
Range on Protein: 338-478
Range on HMM: 15-162/166.0
IFEHVFLGSE--WNASNLEDLQNRGVRYILNVTREID-----NFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTV
|.  .|||       | || |...|. .|. . ..|.       ||  | |  . | |.   ... |   . .|| .. ..| | ||| . |.||||. |
ilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalv

IAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILLASKQ
||| |. || .   |. ||.|||   .||  |..||.||. | ||  .
iayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylaklt
0040439 (Phosphotyrosine protein) phosphatases II 338-469 3.3e-24 81.3 In-house 32-241 (249) alignment 
Range on Protein: 338-469
Range on HMM: 32-241/249.0
IFEHVFLGSEWNASNLED------------------------LQNRGVRYILNVTREIDN----------------------------------------
|.. .||..  ||| ..                         |.. |...|...|..  .                                        
ilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlel

---FFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKK------HGSKCLVHCKMGVSRSASTVIAYAM-----KEYGWNLDRAYDYVKERRTVTKPN
    .. ..... |...|   ...  . .|. .|| ...|       |...||||..||.|..  ..|| |     ||.|..|. |.......|    .|
tnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqn

PSFMRQLEEY
|...|.| |.
peqyrflyea
subfamily_MKPLT_pd Subfamily MKPLT 340-474 5e-32 104.7 In-house 27-161 (164) alignment 
Range on Protein: 340-474
Range on HMM: 27-161/164.0
EHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMKEYG
....||   .| | . |..  . .|.||..|  . || ..|| ...| ||  . | .. . . ||...| . | . |||| .|.|||.|. .|. .|  |
dtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

WNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILL
| |. ||.|.||||....||  |..|| ... ..|
wtlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_MKPLV_pd Subfamily MKPLV 340-474 5e-32 104.7 In-house 27-161 (164) alignment 
Range on Protein: 340-474
Range on HMM: 27-161/164.0
EHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMKEYG
....||   .| | . |..  . .|.||..|  . || ..|| ...| ||  . | .. . . ||...| . | . |||| .|.|||.|. .|. .|  |
dtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskg

WNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILL
| |. ||.|.||||....||  |..|| ... ..|
wtlkeayeylkerrsivapnrGflkqlakfeelil
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 340-469 1.9e-31 102.6 In-house 13-143 (148) alignment 
Range on Protein: 340-469
Range on HMM: 13-143/148.0
EHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPG-VFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMKEY
 ..||||   |..|| |.. ||  | | |.| || .     || .... |..  || |...|  .|..|||..| ..|||..||||||.  .... ..  
afLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfk

GWNLDRAYDYVKERRTVTKPNPSFMRQLEEY
   | .|...||..|   .||. |..|| |.
rvslkealalvkskrryvdpnlgfLkqLael
subfamily_STYXL1_pd Subfamily STYXL1 340-471 3.7e-22 72.2 In-house 17-151 (157) alignment 
Range on Protein: 340-471
Range on HMM: 17-151/157.0
EHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFE---YHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMK
....|| . .| | .  ..  |.  .||. . |... || .     .|.| ||. .|||   ..  .|| | ||.|.  ||  . |.||||. .||| | 
gklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmy

EYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQG
.. ..| .||.|.|. .   ||| .|. ||.|.. 
skkitlkkaykylkkCkenvkPnrafveqlseWek
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 340-470 4.1e-22 72.2 In-house 8-149 (154) alignment 
Range on Protein: 340-470
Range on HMM: 8-149/154.0
EHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGV---------FEYHNIRVYDEEATDLLAYWNDTYKFISKAK--KHGSKCLVHCKMGVSRSAS
 .....|   | |  |||.. .. ||||   |.| |.           .|| |....|.   |..   . ...|| .|    . .| |||.. ||||||.
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

TVIAYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ
 .|.| |..   .|  |.  .|. | . |||  |..||| ..
llisylmdklkislslalellkdsryiikPnqGflkqleife
0038934 (Phosphotyrosine protein) phosphatases II 340-474 6e-20 67.2 In-house 36-177 (194) alignment 
Range on Protein: 340-474
Range on HMM: 36-177/194.0
EHVFLGSEWNASNLEDLQNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEATDL--------LAYWNDTYKFISkAKKHGSKCLVHCKMGVSRSASTVI
| .   | ..  .. .|.|.........| .   . |  || ..|....    |         |  . |  ...  ... | ...||||.|..|..  |.
eelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlva

AYAMKEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQGILL
|| .. .|.... |.....|.|    ||......| .. . | 
aYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelr
0051429 (Phosphotyrosine protein) phosphatases II 340-469 4.9e-17 57.9 In-house 21-220 (272) alignment 
Range on Protein: 340-469
Range on HMM: 21-220/272.0
EHVFLGSEW----NASNLEDLQNRGVRYILNVTREI-------DNFFPGVfEYHNIRVYDEEATDLLAYW------------------------------
..... |      .| ... |.. |...|.....|        | . ||. .|... ..|..|.. | ..                              
pgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgi.rylhlpilddsaptilygalrvtllseellldyilrellltlllsagea

------------------NDTYKFISKAKKhGSKCLVHCKMGVSRSASTVIAYAMKeYGWN--------------LDRAYDYVKERRTVTKPNPSFMRQL
                  .   ....   . | ..||||. |..|..  | .. .  .|..              |..|.......|    ... ....|
revmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfl

EEY
 |.
yea
DSPc Dual specificity phosphatase, catalytic domain 342-470 2.3e-35 116.3 Pfam-A 1-131 (133) alignment 
Range on Protein: 342-470
Range on HMM: 1-131/133.0
VFLGSEWNASnLEDLQNRGVRYILNVTREIDN---FFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMKEY
..|||. .|| |. |.. |. ...|||.|..|   . .. .|| .| | ||. |.. .. .....||.||.. | |.||||..|.||||. .||| ||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ
...|. ||..|||||    || .|.||| ||.
nlslneAyefvkerrskispnagflrqLleye
DSPc Dual specificity phosphatase, catalytic domain 342-470 2.3e-35 116.3 In-house 1-131 (133) alignment 
Range on Protein: 342-470
Range on HMM: 1-131/133.0
VFLGSEWNASnLEDLQNRGVRYILNVTREIDN---FFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMKEY
..|||. .|| |. |.. |. ...|||.|..|   . .. .|| .| | ||. |.. .. .....||.||.. | |.||||..|.||||. .||| ||..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

GWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ
...|. ||..|||||    || .|.||| ||.
nlslneAyefvkerrskispnagflrqLleye
0036941 (Phosphotyrosine protein) phosphatases II 342-470 7.6e-18 60.3 In-house 26-273 (297) alignment 
Range on Protein: 342-470
Range on HMM: 26-273/297.0
VFLGSEWNASNLEDLQ----------------------------------------------------------NRGVRYILNVTREIDNFF--------
 .||| . |...| |.                                                          . .|. |...|..... .        
lllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywp

---PGVFEYHNIRVYDEEA------------------------------------TDLLAYWNDTYKFISKAKK------HGSKCLVHCKMGVSRSASTV
   .....|....|   .                                      ..  ....  .|| ...|       |.. ||||..||.||.. .
leegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfi

IAYAM--------KEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ
.|. |        ||.|...  |. ...|.|    ......|.| |. 
aadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeal
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 343-470 2.1e-14 46.9 In-house 7-138 (145) alignment 
Range on Protein: 343-470
Range on HMM: 7-138/145.0
FLGSEWNASNLEDLQNRGVRYILNVTRE----IDNFFPGVFEYHNIRVYDEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMKEY
. ||  .|...  ||. |.  |.|..       ..     .|   |   | |. ||  ....   || | |. |.  .|||  ||||| .  .|. ||  
yvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkyc

GWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ
.  |  |   |. .|  . ||  |...| . .
nmtlseaarqvrsnrllaypnvtflknllnle
0045450 (Phosphotyrosine protein) phosphatases II 349-469 1.6e-21 72.8 In-house 88-299 (307) alignment 
Range on Protein: 349-469
Range on HMM: 88-299/307.0
NASNL--------------------------------EDLQNRGVRYILNVTREIDN-------FFPGV---------------------FEYHNIRVYD
|||                                  . |.. ||..|...|.....       ..|                       . .....| |
NAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtd

E-----------------EATDLLAYWNDTYKFISKAKK------HGSKCLVHCKMGVSRSASTVIAYAMKEYG--------WNLDRAYDYVKERRTVTK
                    ...  ..... .|| ...|       |...||||..||.|... ..|| |....        ..|. |.....|.|    
ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgav

PNPSFMRQLEEY
.||...|.| |.
qnpeqyrflyea
0040438 (Phosphotyrosine protein) phosphatases II 355-470 3.5e-20 67.9 In-house 105-272 (317) alignment 
Range on Protein: 355-470
Range on HMM: 105-272/317.0
DLQNRGVRYILNVTREIDN---------------------------FFPGVFEYHNIRVYDE----------------EATDLLAYWNDTYKFISKAKKH
 ... ||..|...|.. ..                           .  . .......|.|                    ..  ....  .|.......
mvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrea

----GSKCLVHCKMGVSRSASTVIAYAM-----KEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ
    |...||||..||.|... ..|| |     ||.|.... |.....|.|    ..|...|.| .. 
ledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydal
0039614 (Phosphotyrosine protein) phosphatases II 356-470 1.7e-18 62.6 In-house 121-285 (297) alignment 
Range on Protein: 356-470
Range on HMM: 121-285/297.0
LQNRGVRYILNVTREIDN--------------------FFPGVFEYHNIRV----------------------YDEEATDLLAYWNDTYKFISKAKK---
... ||..|...|.....                     . .|...... |                       |  . ..|..  . .... .| .   
vweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelp

HGSKCLVHCKMGVSRSASTVIAYAM-----KEYGWNLDRAYDYVKERRTVTKPNPSFMRQLEEYQ
 | ..||||..||.|... ..|| |     ||.|.... |.....|.|    ..||..|.| .. 
kggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal
0043336 (Phosphotyrosine protein) phosphatases II 357-469 1.1e-15 53.4 In-house 154-272 (278) alignment 
Range on Protein: 357-469
Range on HMM: 154-272/278.0
QNRGVRYILNVTREIDNFFPGVFEYHNIRVYDEEAT-DLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAM-----KEYGWNLDRAYDYVK
..  ... |.||.  |..   |  || . . | ..  .|  ...   ..... .. ... ||||. ||.|..  ...| .     ||.|..|. |.....
lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelr

ERRTVTKPNPSFMRQLEEY
|.|    ..||..|.| |.
eqRpgavqtpsqyrflyea
0051299 (Phosphotyrosine protein) phosphatases II 358-464 3.3e-11 38.7 In-house 160-276 (288) alignment 
Range on Protein: 358-464
Range on HMM: 160-276/288.0
NRGVRYILNVTRE----IDNFFPGVFEYHNIRVYDEEATDllaYWNDTYKFISKA----KKHGSKCLVHCKMGVSRSASTVIAYAM-----KEYGWNLDR
.  . . | ||.      |..   |  .| .   |  . |   ....  .|. ..    ...|. ..|||. ||.|..  .... .     ||.|... .
ddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpd...spellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvle

AYDYVKERRTVTKPNPSFMR
|. ...|.|    ..|. .|
avkrlreqRpgmvqtpeqyr
0050432 (Phosphotyrosine protein) phosphatases II 358-461 3.2e-10 35.3 In-house 130-286 (308) alignment 
Range on Protein: 358-461
Range on HMM: 130-286/308.0
NRGVRYILNVTREIDNFF-------P-----GVFEYHNIRV----------------------------------YDEEATDLLAYWNDTYKFISKAKKH
. .||.|  .|....|         |     |. ||....|                                   . .  .   ....  .|. ...|.
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrks

--GSKCLVHCKMGVSRSASTVIAYAM-----KEYGWNLDRAYDYVKERRTVTKPNPS
  |....|||. ||.|..  .... .     ||.|...  |. ...|.|    ..|.
lpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe
0047943 (Phosphotyrosine protein) phosphatases II 360-466 1.5e-12 43.0 In-house 101-264 (273) alignment 
Range on Protein: 360-466
Range on HMM: 101-264/273.0
GVRYILNVTREIDNF-------------------------------------------------FPGVFEYHNIRVYDEEATDllaYWNDTYKFISKAKK
.||.|  .|.....                                                     |  .|     |  . .   ....  .|| ...|
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp...slesllefielvrk

------HGSKCLVHCKMGVSRSASTVIAYAM-----KEYGWNLDRAYDYVKERRTVTKPNPSFMRQL
      .... .|||. ||.|... .... .     ||.|.... |. .....|    ..|...|.|
alealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
subfamily_MSG5_pd Subfamily MSG5 361-474 5.9e-17 55.3 In-house 48-161 (165) alignment 
Range on Protein: 361-474
Range on HMM: 48-161/165.0
VRYILNVTREIDNF---FPGvFEYHNIRVydEEATDLLAYWNDTYKFISKAKKHGSKCLVHCKMGVSRSASTVIAYAMKEYGWNLDRAYDYVKERRTVTK
   ..||..||...    |   .|. |.   |  . .    .   . |  |. .. | ||||. |.||||| ..|| || |.  |  ||| .| .    .
fdlvinvakeindlellvpa.vkyyhiew..ehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddis

PNPSFMRQLEEYQGILL
|.  .. || |.. .| 
psiglifqlmewevals
0046845 (Phosphotyrosine protein) phosphatases II 362-462 3.1e-09 32.1 In-house 150-262 (284) alignment 
Range on Protein: 362-462
Range on HMM: 150-262/284.0
RYILNVTRE-IDNFFPGVFEYHNIRVYDEE----ATDLLAYWNDTYKFISKaKKHGSKCLVHCKMGVSRSASTVIAYAMKEY--------GWNLDRAYDY
.. | .|.. ....   |  .| .   |      ..|||.....  .....  . |.. .|||. ||.|..  .... ..|.        |...  |. .
vrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkr

VKERRTVTKPNPSF
..|.|     ... 
lreqRpgmvqtleq
0048567 (Phosphotyrosine protein) phosphatases II 394-454 3.2e-07 24.9 In-house 56-119 (157) alignment 
Range on Protein: 394-454
Range on HMM: 56-119/157.0
LLAYWNDTYKFISKAKKHGSKCLVHCKMGV---SRSASTVIAYAMKEYGWNLDRAYDYVKERRT
|  ...  .||..  ...| .  ||||.|    .|.|  . .|... .|.. . |.....  | 
lyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrp