Gene STYX in Homo sapiens

Synonym: STYX

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily STYX
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP044_AA protein Get Run
HsapP044_AA_26-178 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0045450 (Phosphotyrosine protein) phosphatases II 13-175 1.9e-27 92.3 In-house 17-304 (307) alignment 
Range on Protein: 13-175
Range on HMM: 17-304/307.0
QCKEDAEEWTYPMRREMQEILPGLF--LGPYSSAMKSK--------------------------------------------------------------
.....  .. . ...|....|.     ||.||.|.. .                                                              
lvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPl

-------LPVLQKHGITHIICIRQNIEA-----------------------NFIKPNFQQLFRYLVLDIADN-----------------PVENIIRFFPM
       .  |...|.|.|..... .|                        .... . .. . ...| . |.                 |  ..  .| .
petvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfee

TKEFIDGSLQ------MGGKVLVHGNAGISRSAAFVIAYIMETFG--------MKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIYL
. .||.  ..       ||.|||| .||..|...|..||.| . .        . ...|.....|.| .. .| .. ..|.|... .|
lldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0044763 (Phosphotyrosine protein) phosphatases II 16-175 1.4e-38 127.6 In-house 10-171 (178) alignment 
Range on Protein: 16-175
Range on HMM: 10-171/178.0
EDAEEWTYPMRREMQEILPGLFLGPYSSAmkSKLPVLQKHGITHIICIRQNIEANFIKpNFQQL-----FRYLVLDIADNPVENIIRFFPMTKEFIDGSL
.  | . . .   . ||||||.||.. .|  . |. |...|||||.......| .|.| ....      ..|| . | |..| .....|. . |||.  |
snleglersdyinaseilpglylgslppa..ddlellkelgithivnlteelelgflk.cdpywpeeagiqylhipipDhgvpdllehflefvefieeal

-QMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQERRFcINPNAGFVHQLQEYEAIYL
 . ||.|||| .||..||...|.||.| ..|. . .|...|.|||. |.|| |...||.|.| ..|
dekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrll
subfamily_STYX_pd Subfamily STYX 19-183 1.5e-105 343.4 In-house 2-166 (166) alignment 
Range on Protein: 19-183
Range on HMM: 2-166/166.0
EEWTYPMRREMQEILPGLFLGPYSSAMKSKLPVLQKHGITHIICIRQNIEANFIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLV
|||||..|||||||||||||||||.||||||.||.|||||||.|||||||||.|||||.. |||||||.|||.||||||..|..|||||.|||.||||||
eewtyskrremqeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlv

HGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIYLAKLTIQMM
|||||||||||.||||||||.|.|||.|||||||||||||||.|||.||.||||||||||||...
hgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylakltikll
0041856 (Phosphotyrosine protein) phosphatases II 20-178 2.8e-33 110.4 In-house 10-176 (182) alignment 
Range on Protein: 20-178
Range on HMM: 10-176/182.0
EWTYPMRREMQEILPGLFLGPYSS------------AMKSKLPVLQKHGITHIICIRqnIEANFIKPNFQQLFRYLVLDIADNPVENiirfFPMTKEFID
 . |.. | . .|...|.||.. .             . . |. |...|||.|....   |  . .   .. ..|| | . |..| .    .... .||.
ilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfie

GSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQERRF--CINPNAGFVHQLQEYEAIYLAKL
  |. ||.|||| .||..|....|.||.|.. |. ...|...|..||.  .|.|| .|. ||...| ..| | 
evleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt
0036941 (Phosphotyrosine protein) phosphatases II 20-182 2.1e-25 85.1 In-house 10-284 (297) alignment 
Range on Protein: 20-182
Range on HMM: 10-284/297.0
EWTYPMRREMQEILPGLFLGPYSSAMKSKLPV--------------------------------------------------------LQKHGITHIICI
 ... ...|..|.|| |.||..| |.. .                                                           . ....|.|...
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvml

RQNIEANFIK-----PNF---------------------QQLFRYLVLDIAD----------------NPVENIIRFFPMTKEFIDGSLQ------MGGK
 . .| ...|     |.                       . . . .| . |                 |  ..   .    .||.  ..       ||.
telvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggp

VLVHGNAGISRSAAFVIAYIM--------ETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIYLAKLTIQM
|||| .||..||..|..|..|        .. |. . .|. .. |.|... .. .. ..| |... .| | .. .
vlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
0045098 (Phosphotyrosine protein) phosphatases II 21-176 2e-28 95.0 In-house 14-273 (278) alignment 
Range on Protein: 21-176
Range on HMM: 14-273/278.0
WTYPMRREMQEILPGLFLGPYS---------------------------------------SAMKSKLPVLQKHGITHIICIRQNIEA------------
.  ..   ..||.|.|.||...                                       | . . .  |...|||.|... . .|             
efllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeg

-----------------------------------NFIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQ--------------MGGKVLVHG
                                   . ..... . . ||  .  . | ..|...|    |||.  |.               ||.|||| 
gsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHC

NAGISRSAAFVIAYIMETF---GMKYRDAFAYVQERRFC-INPNAGFVHQLQEYEAIYLA
.||..|....|.||.| .    |. . .|.......| . . .| .. ..| |... .| 
saGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllelll
0040439 (Phosphotyrosine protein) phosphatases II 22-175 2.2e-28 95.0 In-house 22-246 (249) alignment 
Range on Protein: 22-175
Range on HMM: 22-246/249.0
TYPMRREMQEILPGLFLGPYSSAMKSKLP----------------------VLQKHGITHIICIRQNIEANFIKP-------------------------
 |.  |   .|||||||. |  |   ...                       |...|||.|.....  | ...|                          
pydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevk

-------------NFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQ------MGGKVLVHGNAGISRSAAFVIAYIM-----ETFGMKYRDAFAYV
              ... ...|.. . | |  ..  .|. . .||.  ..       ||.|||| .||..|...|..||.|     .. |. . .|....
ddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkll

QERRFCINPNAGFVHQLQEYEAIYL
...|... .| ..  .|.|... .|
rsqRpgavqnpeqyrflyeallell
PTEN_1 23-176 1.3e-26 88.7 In-house 35-193 (196) alignment 
Range on Protein: 23-176
Range on HMM: 35-193/196.0
YPMRREMQEILPGLFLGPYSSAmKSKLPVLQKHGITHIICIRQNIEA----NFIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQ--MGGKV
 |.|  .||| .||..|.....  . |  |...|||....     |        .  |.. ..|| ..| | .. .. ..| . |.||.  |.   |..|
apsrpllqeideglyrgslkdv.aadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvV

LVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIYLA
|||  ||..||.  |.|| |.. .. ...|...|.|.| ...|| ..  .|.||.|  ||
lVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaella
subfamily_DSP6_pd Subfamily DSP6 26-172 1.3e-32 106.5 In-house 11-152 (158) alignment 
Range on Protein: 26-172
Range on HMM: 11-152/158.0
RREMQEILPGLFLGPYSSAMksKLPVLQKHGITHIICIRQNIEANFIKpnfQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGIS
..   |||| |.||   .|   .| ||.|..| ... . .|..  | .   .. ..|| . | |.  .|. .||| . |||| . .   |||||  ||||
aefpveilpllylGsakdas..nlevlkklkikyvlnvtsnlpnkfee...sgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGis

RSAAFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEA
|| . ..||.|..  .   ||...|..|.  | ||  |. || ..| 
rsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfer
subfamily_DSP10_pd Subfamily DSP10 27-173 1.2e-34 113.5 In-house 12-152 (159) alignment 
Range on Protein: 27-173
Range on HMM: 12-152/159.0
REMQEILPGLFLGPYSSAMKSKlpVLQKHGITHIICIRQNIEANFIKpnfqQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISR
 .. ..|| ||||    | . .  .|....||... . ...  .| .    . ..|  ... |.  .|. . |    |||.   . | .|||| .|||||
apasqvlpfLflGsekdaadld..aldrlnitavlnvttsvPnefee....ealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisr

SAAFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAI
||..||||.|. .... .||. .|.|.|  | || .|. || |.|  
satvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefeke
subfamily_DSP14_pd Subfamily DSP14 27-184 6.7e-34 111.1 In-house 5-154 (157) alignment 
Range on Protein: 27-184
Range on HMM: 5-154/157.0
REMQEILPGLFLGpYSSAMKSKlpVLQKHGITHIICIRQNIEAnfikPNFQQLFrYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISR
... .| | |||.  ..|.. .  .|.|..||.|| . ... .    ......  .. . ..||| ... ..| .. . |.   . |||.|||  ||.||
aalsqitpsLfls.gvaalske..llkkkkitliinvtvelpn....tklkdie.rvkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSR

SAAFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIYLAKLTIQMMS
||....||.|..  .  |.|. .|...|  |.|| || .||..||    .| ...|..
SAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvkmvd
subfamily_DSP3_pd Subfamily DSP3 27-171 3.7e-31 101.9 In-house 9-154 (162) alignment 
Range on Protein: 27-171
Range on HMM: 9-154/162.0
REMQEILPGLFLGPYSSAMKSKlpVLQKHGITHIICIRQN-IEANFIKPNFQQ--LFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQM-GGKVLVHGNA
.|..|. |.|..|  ..|.. .   |.| ||||..   .  .     ...| .   ..|| |.. |.|  .. ..|  . .||| .|.   |||||| ..
kevdevypklyvgdeavakdks..kLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvv

GISRSAAFVIAYIMETFGMKYRDAFAYVQERRfCINPNAGFVHQLQEYE
|.||||. |.||.| .  |.  .|   |...| .| || ||..||.|..
GvsRsatlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeld
PTPc_motif_SM00404 28-172 1.7e-42 139.6 In-house 1-139 (140) alignment 
Range on Protein: 28-172
Range on HMM: 1-139/140.0
EMQEILPGLFLGPYSSAMksKLPVLQKHGITHIICIRQNIEANfikpNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRS
|...|||.|.|| .|.|.  ....|.|.||||.|.. ......    . .. |..| ... || .... ........||. . . |||||||  ||.|||
epsrilphlylgskskaq..npallkklgithvinvteevslt....kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRS

AAFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEA
|...|||.|.. ......|. .|.||| .|.||..||.||.||| 
atliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP19_pd Subfamily DSP19 28-173 8.9e-41 133.8 In-house 11-149 (152) alignment 
Range on Protein: 28-173
Range on HMM: 11-149/152.0
EMQEILPGLFLGPYSSAMKskLPVLQKHGITHIICIRQNIEANfikpnFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRS
|..|. | |.||  ..|..     |....||||. .  ...       | . | || ..| |.| ........ . .||. ...  | |||| |||.|||
evgeveprlylgsqdvaad..keilkekkitHilnvatgvpnv.....fpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRs

AAFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAI
|..||||.|..  .....|. .|.| | ||.||.||..||.|||| 
asvviaylmkkeelsleealelvrearpcikPneGFikqLkeyeae
subfamily_DSP8_pd Subfamily DSP8 28-172 1.9e-32 106.0 In-house 14-152 (159) alignment 
Range on Protein: 28-172
Range on HMM: 14-152/159.0
EMQEILPGLFLGPYSSAMKSKlpVLQKHGITHIIcirqNIEANFIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRS
....||. |.||    .....  .|.| ||....    |.. . .|... .  ..| . . |.  |... .|... ||||   .  |.||||  ||||||
gptrilknlylGsqkdvlsee..llsklgisyvl....nasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrs

AAFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEA
|. .||||| |. |.. .|. .|.|.|  |.||  |. || ||| 
atvaiayimktlemsldeayrfvkekrptispnlnflgqLleyek
0046846 (Phosphotyrosine protein) phosphatases II 28-176 3.2e-31 103.8 In-house 11-174 (176) alignment 
Range on Protein: 28-176
Range on HMM: 11-174/176.0
EMQEILPGLFLGPYS--------SAMKSKLPVLQKHGITHIICIRQNIEANFIK-PNFQQL-----FRYLVLDIADNPVENIiRFFPMTKEFIDGSLQMG
 . .|...|.||..         . . . |  |...|||..... . .| ...| ||. ..     ..||.|.. |. | .. . ..   |||.  |. |
dldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeg

GKVLVHGNAGISRSAAFVIAYIMET-FGMKYRDAFAYVQERRF-CINPNAGFVHQLQEYEAIYLA
|.||||  |||.|....|.||..|. .|... .|.|.|.|.|. .. .. .....|.|.|  .| 
gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefellllk
subfamily_DSP1_pd Subfamily DSP1 29-175 1.8e-39 129.4 In-house 18-157 (163) alignment 
Range on Protein: 29-175
Range on HMM: 18-157/163.0
MQEILPGLFLGpySSAMKSKLPVLQKHGITHIICIRQNIEANfikpnFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSA
...||. |.||  |.   |.| .|...|||.|. . ....       |..||.|  | . |.| ..|   |    ||||   ...||||.| .||||||.
vekildfLylG..setvasnleiLkslgitailnvskeldnv.....fedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRss

AFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIYL
....||.|.|  ... .|| .|..|| .|.|||||| || .||   |
tlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_DSP15_pd Subfamily DSP15 29-180 3.5e-36 118.6 In-house 2-145 (151) alignment 
Range on Protein: 29-180
Range on HMM: 2-145/151.0
MQEILPGLFLGPYSSAMKSKLpvLQKHGITHIICIRQnieanFIKPNFQQlFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSA
....||||.|| .  . ...|  |... ||||. . .       |. ... ..|... ..| |  .. .||  . |||  .   ...||||  ||.|||.
iskvlpglylgnfrdskdeel..Lkeknithilsvhd.....nakkllkd.ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsv

AFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIYLAKLTI
  |.||.|    ...|||.  ....|.. |||.|| .||.|||   |...  
tlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklkeyrk
0048076 (Phosphotyrosine protein) phosphatases II 29-174 3.7e-35 116.1 In-house 4-142 (145) alignment 
Range on Protein: 29-174
Range on HMM: 4-142/145.0
MQEILPGLFLGPYSSAMKskLPVLQKHGITHIICIrqnieANFIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSA
..||||||.||.. .|..  |. |...|||.....     .. ..  ... ..|| |.. |..| .......   |||.  |. ||.|||| .||..|..
pseilpglylgslptald..lellkdlgittvlnl.....tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtg

AFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIY
..|.||.| ..|. . .|...|...|....|| |....|.|.| ..
tlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 29-172 4.4e-35 115.8 In-house 4-142 (144) alignment 
Range on Protein: 29-172
Range on HMM: 4-142/144.0
MQEILPGLFLGPYSSAMKskLPVLQKHGITHIICIRQNIEANFIKPNfqqLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSA
. ||||||.||.. .|..  |. |.|.|||..|... . | .| ...    ..|| |.. |..| ... ... . |||.  |. ||.|||| .||..|..
pseilpglylgslptald..lellkklgittvinlteeyepeflere...giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtg

AFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEA
..|.||.| ..|. . .|.|.|..||....|| |....|.||| 
tlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek
subfamily_DSP12_pd Subfamily DSP12 29-174 1.1e-34 114.1 In-house 2-143 (155) alignment 
Range on Protein: 29-174
Range on HMM: 2-143/155.0
MQEILPGLFLGPYSSAMKSklPVLQKHGITHIICIRQN-IEANFIKPNFQQlfrYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRS
...|||||.||  . ...   . |.. .|||.. . .. ..   .|..  .   .. ..|.|.| |.|..... . .||. .|. .|.|||| .||.|||
vsrilpglylggleavqee..ellkelkithvlsvikeelpehklkkgkvs...tkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRS

AAFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIY
...||||.| . ...  .|.  |.| .  |.||.||..||. .|.. 
vtiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmg
subfamily_LRR-DSP_pd Subfamily LRR-DSP 30-172 1.5e-35 116.6 In-house 121-256 (263) alignment 
Range on Protein: 30-172
Range on HMM: 121-256/263.0
QEILPGLFLGPYSSAMKSklPVLQKHGITHIICIRQNieanfIKPNFQQLFRYLVL-DIADNPVENIIRFFPMTKEFIDGSLQMGGkVLVHGNAGISRSA
.||...||||   ||.    ..|.. |.|||.    .     ..| | .||.||.. || | .  .| ..|  |  ||.   . || ||||  ||.|||.
deiidklflGgldsannk..silkdlgvthillavad.....fePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrss

AFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEA
. ||.|.|    .|...|.  |...|  |.|| ||..||. ||.
tlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
0036282 (Phosphotyrosine protein) phosphatases II 30-172 6.6e-25 83.2 In-house 13-167 (174) alignment 
Range on Protein: 30-172
Range on HMM: 13-167/174.0
QEILPGLFLGPYSSAmksKLPVLQKHGITHIICIRQNIEAN----------FIKPNFQQLFRYLVLDIADNPVENIIRfFPMTKEFIDGSLQM--GGKVL
 .|.|.|..| .  |    .. |...|||.... .. .| .          . .   .  ..|| | . |. | ..   .    .|..  |.   ||.||
syitprliagqgpla...fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvl

VHGNAGISRSAAFVIAYIMETFGM-KYRDAFAYVQERR---FCINPNAGFVHQLQEYEA
|| .||..|....|.||.|.. .. ...||...|.|.|    .. .. .. ..|...| 
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
subfamily_STYXL1_pd Subfamily STYXL1 30-173 3.8e-22 72.2 In-house 12-152 (157) alignment 
Range on Protein: 30-173
Range on HMM: 12-152/157.0
QEILPG-LFLGPYSSAMKSKLPvlQKHGITHIICIRQNIEAnfIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSA
 |.||| |.|| |. |.. ..   .   .   . . .. .   .    ..  . | ... |..  ... ..    .||.   . |  ||| .| ||||||
vevlPgklylGnykqaqnpaik..kdlkvkahvnvsmdadk..liagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsa

AFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAI
| .|||.|    .....|..|... .  ..|| .||.||.|.|  
aviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekq
subfamily_Slingshot_pd Subfamily Slingshot 31-177 2.3e-33 109.0 In-house 21-160 (169) alignment 
Range on Protein: 31-177
Range on HMM: 21-160/169.0
EILPGLFLGPYSSAmkSKLPVLQKHGITHIICIRQNIEaNFikpnFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAF
.|   ..||    |  |.|  |...|...|. . ..|. ||    |.. |.|| . . |.. .......  | .||. . . | |||||   |.||||. 
kifdhvylGsewna..snleelkengveyilnvtkeid.nf....fpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsast

VIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIYLAK
|||| | ..|... .|..||.||| .|.||.||..||.||| |  |.
viayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGileas
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 31-172 6.1e-27 87.9 In-house 9-145 (148) alignment 
Range on Protein: 31-172
Range on HMM: 9-145/148.0
EILPG-LFLGPYSSAmkSKLPVLQKHGITHIICIRQNIEANFIkpnfQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAA
|| .. ||||   ||  ..| .|.. |.|.|.   .. .  .     |.  .|| . ..|.| |..  .|.   .|..   . |..|||| . |.|||.|
eikdafLFlGskksa..adlealkalgvtrivnatkerdnald....qrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssa

FVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEA
 ........  .  ..|.|.|...|  ..|| ||..||.|.| 
lallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
0051082 (Phosphotyrosine protein) phosphatases II 31-170 9.9e-22 72.6 In-house 10-149 (151) alignment 
Range on Protein: 31-170
Range on HMM: 10-149/151.0
EILPGLFLGPYSSAmkSKLPVLQKHGITHIICIRQNIEANfI-KPNFQQ-LFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQM-GGKVLVHGNAGISRS
 . .||... . .|    |. |...||..|...|.  | .   .  ...  ...| . | |.|. ..  .|.  .||..  |.. .|.|||| .||..|.
yvtgglyrsggpla..dflellkelgiktivnlrseeerg.ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRT

AAFVIAYIMEtFGMKYRDAFAYVQERRF-CINPNAGFVHQLQEY
...|..|.|   |. . .|.......|. ...|| .|. ||...
Gtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal
DSPc Dual specificity phosphatase, catalytic domain 36-172 3.5e-39 128.7 Pfam-A 1-132 (133) alignment 
Range on Protein: 36-172
Range on HMM: 1-132/133.0
LFLGPYSSAMkskLPVLQKHGITHIICIRQNIEA-NFIKPNFQQLFRYLVLDiadNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAY
|.|| .|.|.   |..|.|.|||..| . ..... |.||.. .. .|. | |   .  ..| .......|||.   | |.||||| .|||||||...|||
lylgskstas...lalleklgitlvinvtkevpnnnaikkseieylripved...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaY

IMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEA
.|.|.......|...|.||| .|.|||||..|| ||| 
lmktknlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 36-172 3.5e-39 128.7 In-house 1-132 (133) alignment 
Range on Protein: 36-172
Range on HMM: 1-132/133.0
LFLGPYSSAMkskLPVLQKHGITHIICIRQNIEA-NFIKPNFQQLFRYLVLDiadNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAY
|.|| .|.|.   |..|.|.|||..| . ..... |.||.. .. .|. | |   .  ..| .......|||.   | |.||||| .|||||||...|||
lylgskstas...lalleklgitlvinvtkevpnnnaikkseieylripved...etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaY

IMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEA
.|.|.......|...|.||| .|.|||||..|| ||| 
lmktknlslneAyefvkerrskispnagflrqLleyer
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 36-171 3.2e-27 88.8 In-house 10-149 (154) alignment 
Range on Protein: 36-171
Range on HMM: 10-149/154.0
LFLGPYSSAMKSkLpVLQKHGITHIICIRQNIEANFIKP----NFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSL--QMGGKVLVHGNAGISRSAA
|... . .|.   |  ||.. |..|. .   |.  | .     |   .. || |.. |..  .||. . .. |||| ..     .||||| ..|.|||||
lyissfdaalnk.l.dlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

FVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYE
..|.|.|.   . .  |.  ... |. |.|| ||..||. .|
llisylmdklkislslalellkdsryiikPnqGflkqleife
0049260 (Phosphotyrosine protein) phosphatases II 37-172 1.1e-30 101.7 In-house 14-147 (152) alignment 
Range on Protein: 37-172
Range on HMM: 14-147/152.0
FLGPYSSAMKSKLPVLQKHGITHIICIRQNIEanFIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDG-SLQMGGKVLVHGNAGISRSAAFVIAYI
..||..  ... .  |...|||.|... .  |  . |. . |...|| | . |..| ... ....  .||.   |. ||.||||  ||..|....|.||.
tqgpgpntladfwrmlkelgittivmltelle..lgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaayl

MEtFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEA
|. .|... .|.|.|.|.| ...|| |.  .|.|.| 
ml.lgvsleeavalvrekRpgavpnpgqlrflyefek
0043147 (Phosphotyrosine protein) phosphatases II 37-174 1.4e-30 101.7 In-house 25-160 (172) alignment 
Range on Protein: 37-174
Range on HMM: 25-160/172.0
FLGPYSSAMKSKLPVLQKHGITHIICIRQNieANFIKPNFQQLFRYLVLDIADNPVEnIIRFFPMTKEFIDG--SLQMGGKVLVHGNAGISRSAAFVIAY
..||... . . .  |...|||||... .    .  .. ... ..|| | . |..|  ...... . ||||    |. ||.||||  ||..|....|.||
tqgplrntladfwrmlkelgithivnltel..lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaay

IMEtFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIY
.|.  |... .|.|.|.|.|... .| .. ..|...| ..
lml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
0037934 (Phosphotyrosine protein) phosphatases II 39-174 6.1e-26 86.9 In-house 51-241 (243) alignment 
Range on Protein: 39-174
Range on HMM: 51-241/243.0
GPYSSAMKS----KLPVLQKHGITHIICIRQNIEANFI----------------------------------------KPNFQQLFRYLVLDIAD----N
|| ..  ..     .  |...|||.|..... .| . .                                        .. ... ..|. | . |    .
gPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPd

PVENIIRFFPMTKEFIDG-----SLQMGGKVLVHGNAGISRSAAFVIAYIMETF-GMKYRDAFAYVQERRFC-INPNAGFVHQLQEYEAIY
 .|....|. ...|||.       |  ||.||||  ||..|......||.| .  |. . .|.....|.|.. . .. .. ..|.|... .
spedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeallel
0040438 (Phosphotyrosine protein) phosphatases II 39-177 1.8e-22 75.5 In-house 93-278 (317) alignment 
Range on Protein: 39-177
Range on HMM: 93-278/317.0
GPYSSAMKSKLPVLQKHGITHIICIRQNIEA----------------------NFIKPNFQQLFRYLVLDIADN----------------PVENIIRFFP
|| .. . . .  ....|.|.|... .  |                       ....    . . ...| . |.                |  ..   . 
gPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspd

MTKEFIDGSLQM----GGKVLVHGNAGISRSAAFVIAYIM-----ETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIYLAK
   .|..   .     ||.|||| .||..|...|..||.|     .. |. . .|.....|.| .. .. .. ..| .... || .
llldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
0047943 (Phosphotyrosine protein) phosphatases II 39-174 1.2e-14 49.9 In-house 84-271 (273) alignment 
Range on Protein: 39-174
Range on HMM: 84-271/273.0
GPYSSAMKSKLPVLQKHGITHIICIRQNIEANFI--------------------------------------------KPNFQQLFRYLVLDIADNPVEN
|| .. ... .  . ......|... . .| . .                                             ..  .   ...... |. |  
gPlpntvedfwrmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvpp

IIRFFPMTKEFIDGSLQ---MGGKVLVHGNAGISRSAAFVIAYIM-----ETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIY
 .  .    |...  |.    .|.|.|| .||..|...|......     .. |. . .|.......|... ..  .  .| |. . |
slesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0050432 (Phosphotyrosine protein) phosphatases II 39-177 4.3e-12 41.4 In-house 115-295 (308) alignment 
Range on Protein: 39-177
Range on HMM: 115-295/308.0
GPYSSAMKSKLPVLQKHGITHIICIRQNIEANFIKpnfqqLFRYLVLDIA-------------------------------------------------D
||... ...    . ......|... . .| . .|      ..|  |..                                                  |
gPlpntvedFwrmvweqnvrvIvmLtklvengrek.....caqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpd

--NP--VENIIRFFPMTKEFIDGslqmgGKVLVHGNAGISRSAAFVIAYIM-----ETFGMKYRDAFAYVQERRfcinpnAGFVHQLQEYEAIYLAK
   |  .| ...|. . .....|     |...|| .||..|...|......     .. |. . .|.... |.|      .| |. .. |. .| | 
hgvPpspeilldflelvrkslpg.....gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqR......pgmvqtpeqylflyral
0039614 (Phosphotyrosine protein) phosphatases II 40-176 2.2e-22 75.3 In-house 109-290 (297) alignment 
Range on Protein: 40-176
Range on HMM: 109-290/297.0
PYSSAMKSKLPVLQKHGITHIICIRQNIEA--------------------NFIKPNFQQLFR-----------------YLVLDIADNPVENIIRFFPMT
| .. ... .  ....|.|.|... . .|                     ...|    . .                  ...... |. | .... .   
PlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllef

KEFIDGSLQ---MGGKVLVHGNAGISRSAAFVIAYIM-----ETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIYLA
 |...  |.    ||.|||| .||..|...|..||.|     .. |. . .|.....|.| .. .. .. ..|..... .| 
lelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0046845 (Phosphotyrosine protein) phosphatases II 40-178 1.3e-14 49.7 In-house 85-271 (284) alignment 
Range on Protein: 40-178
Range on HMM: 85-271/284.0
PYSSAMKSKLPVLQKHGITHIICIRQNIEANFI-------------------------------------------KPNFQQLFRYLVLDIADN----PV
| .. ...   .. ......|... . .| . .                                           . .  ..  . .... |.     .
PlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppsp

ENIIRFFPMTKEFIDGsLQMGGKVLVHGNAGISRSAAFVIAYIMETF--------GMKYRDAFAYVQERRfcinpnAGFVHQLQEYEAIYLAKL
|....|. . .|...  |  ||...||  ||..|...|...... .         |. . .|.... |.|       |.|..|. |. .| | |
edlleflrlvrellen.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqR......pgmvqtleqyrfvyeall
subfamily_PRL_pd Subfamily PRL 41-171 1e-06 22.9 In-house 19-146 (151) alignment 
Range on Protein: 41-171
Range on HMM: 19-146/151.0
YSSAMKSKLPVLQKHGITHII-CIRQNIEANFIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMggKVLVHGNAGISRSAAFVIAYIMETf
 ......    |.|....... .   . ... .. .  ..  .   | |  | | . ... . ||    . .    | ||  ||. |.  .|   ..|. 
tdatlekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepks..tvavhcvaGlGraPvlvalaliea.

GMKYRDAFAYVQERR-FCINpnAGFVHQLQEYE
||||.||  ...|.|  .||  .  .. |..| 
Gmkyedavefirekrrgain..skqlkflekyk
0042113 (Phosphotyrosine protein) phosphatases II 45-175 1.3e-24 82.5 In-house 65-243 (245) alignment 
Range on Protein: 45-175
Range on HMM: 65-243/245.0
MKSKLPVLQKHGITHIICIRQNIEANF-----------------------------------------IKPNFQQLFRYLVLDIADNPVENIIRFFPMTK
 .  .  |...|||.|.....  | ..                                          ..  .. ..|. |.. |..| .... .    
vedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldfl

EFIDGSLQ--MGGKVLVHGNAGISRSAAFVIAYIM-----ETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIYL
||..  |.   .|.|||| .||..|...|..||.|     .. |.   .|.......| .. .. .. ..|.|... .|
efvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 45-170 2.2e-13 43.5 In-house 13-137 (145) alignment 
Range on Protein: 45-170
Range on HMM: 13-137/145.0
MKSKLPVLQKHGITHIICIRQNiEANFIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYR
  ...|.||. ||. |. .    ..   .    . .  |..   |    .. . |    .|||   . |  |.||  ||.||| .  .|..|   .|   
handvptlqelgisrivnmaag.slvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtls

DAFAYVQERRFCINPNAGFVHQLQEY
.|   |. .|.   ||  |...| . 
eaarqvrsnrllaypnvtflknllnl
0051429 (Phosphotyrosine protein) phosphatases II 46-178 2.5e-20 68.7 In-house 35-228 (272) alignment 
Range on Protein: 46-178
Range on HMM: 35-228/272.0
KSKLPVLQKHGITHIICIRQNIEANFIK-PNFQQLFRYLVLDIADNPVENIIRFF---------------------------------------------
   .. |...||..|...|.  | .. | . . . .|||.|.| |. .. |  ..                                             
aadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhg

---PMTKEFIDGSLQmGGKVLVHGNAGISRSAAFVIAYIMEtFGMK--------------YRDAFAYVQERRFCINPNAGFVHQLQEYEAIYLAKL
      .|...  |. ||.|||| .||..|.. .| ....   |.               ...| ......| ..... .....|.|... .| .|
vpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsl
0043336 (Phosphotyrosine protein) phosphatases II 47-174 3e-19 65.0 In-house 103-276 (278) alignment 
Range on Protein: 47-174
Range on HMM: 103-276/278.0
SKLPVLQKHGITHIICIRQNIEANF----------------------------------------IKPNFQQLFRYLVLDIADNPVE-NIIRFFPMTKEF
     ....|.|.|.....  | .                                          ... ..  .|  |.. |. |  ..  .. . |..
dFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

IDGSLQMGGKVLVHGNAGISRSAAFVIAYIM-----ETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIY
..     .|.|||| .||..|...|...|..      . |. . .|.....|.|... ..  . ..| |... |
realedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0049772 (Phosphotyrosine protein) phosphatases II 49-177 2.3e-29 98.5 In-house 163-276 (314) alignment 
Range on Protein: 49-177
Range on HMM: 163-276/314.0
LPVLQkhgithiicirqniEANFIKPNFQQL-FRYLVLDIADnPVENIIRFFPMTKEFIDGSlQMGGKVLVHGNAGISRSA-AFVIAYIMETFGMKYRDA
|. |.              |  . .. |..| ..|| ... | . ......|.   |||.   . ||.|||| .||..|.. . |.||.|  .|. ...|
lellk..............eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleea

FAYVQERRFcINPNAGFVHQLQEYEAIYLAK
...|...|. |||| ||..||..|| |. |.
ledvrlkRp.inpnpgfieqleqyefileal
0051299 (Phosphotyrosine protein) phosphatases II 50-161 2.6e-14 48.8 In-house 110-272 (288) alignment 
Range on Protein: 50-161
Range on HMM: 110-272/288.0
PVLQKHGITHIICIRQNIEANF---------------------------------------------IKPNFQQLFRYLVLDIADNPVEN-IIRFFPMTK
  . ......|... . .| .                                               . . ..   . .... |. | . .  .. . .
rmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflr

EFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIM-----ETFGMKYRDAFAYVQERRFCINPNA
....   . || |.|| .||..|...|......     .. |. . .|.... |.|... .. 
lvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp
subfamily_MKPLT_pd Subfamily MKPLT 51-177 7.4e-28 91.1 In-house 42-163 (164) alignment 
Range on Protein: 51-177
Range on HMM: 42-163/164.0
VLQKHGITHIICIRQNIEAnfikpNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYV
||..  ||||. . |.        .| . . || ... |.. |... |.  ...|.  ... ||.|||| . | |||..  .|....  |  ...|. |.
vlkdlkithivnvsqekkd.....afpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeyl

QERRFCINPNAGFVHQLQEYEAIYLAK
.||| ...|| ||. || ..| . | |
kerrsivapnrGflkqlakfeelilGk
subfamily_MKPLV_pd Subfamily MKPLV 51-177 7.4e-28 91.1 In-house 42-163 (164) alignment 
Range on Protein: 51-177
Range on HMM: 42-163/164.0
VLQKHGITHIICIRQNIEAnfikpNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYV
||..  ||||. . |.        .| . . || ... |.. |... |.  ...|.  ... ||.|||| . | |||..  .|....  |  ...|. |.
vlkdlkithivnvsqekkd.....afpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeyl

QERRFCINPNAGFVHQLQEYEAIYLAK
.||| ...|| ||. || ..| . | |
kerrsivapnrGflkqlakfeelilGk
0038934 (Phosphotyrosine protein) phosphatases II 51-171 5e-16 54.4 In-house 49-173 (194) alignment 
Range on Protein: 51-171
Range on HMM: 49-173/194.0
VLQKHGITHIICIRQNIEANFIKPNFQ--QLFRYLVLDIADN----PVENIIRFFPMTKEFIDGSlqMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYR
.|. ..  .   |. . .  .  |.      ..|| | . |     . |.. ||. . .||.. .   ||.|.||  ||..|.. .|.||.....||...
ylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflned..pggvvaVHCkaGlgRtGtlvaaYLiyrlgmsae

DAFAYVQERRFCINPNAGFVHQLQEYE
.| |...|.|  . || .....|... 
eAialfrekRpgaipnqdyleallkry
subfamily_PTPMT1_pd Subfamily PTPMT1 51-175 8.9e-14 46.3 In-house 41-169 (171) alignment 
Range on Protein: 51-175
Range on HMM: 41-169/171.0
VLQKHGITHIICIRQNIEANFIKPNFQQ-------LFRYLVLDIADNPVENIIrffPMTKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMKY
...|. .  ....... | ...  . ..        ... . |....|  . .     . |||.   . | .| || .|| .|||. |..|.| .  .. 
LiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdlekl...ekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklsp

RDAFAYVQERRFCINPNAGFVHQLQEYEAIYL
 .|  .....|  |. .   ...|||||  .|
eeAlkalkkkRkiirlakkqwkalqeyeekll
subfamily_CDC14_pd Subfamily CDC14 52-154 3.1e-07 24.5 In-house 208-304 (328) alignment 
Range on Protein: 52-154
Range on HMM: 208-304/328.0
LQKHGITHIICIRQNI--EANFIKPNFQQLFRYLVlDiADNPVENIIrffpmtKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAY
 .|...|... . ...  . .| .  |.    . . |    | ..|.      |.|.. . .. |.. ||  ||. |  ... .|.|.....   .| |.
frknnvttvvrLnkklYdakkftdaGfdhkDlffi.D.GstPsdaiv......kkfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiaw

VQERR
..  |
lricr
subfamily_Laforin_pd Subfamily Laforin 64-151 2e-08 27.3 In-house 61-148 (183) alignment 
Range on Protein: 64-151
Range on HMM: 61-148/183.0
RQNIEANFIKPNFQQLFRYLVLDIADNPVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQ
 .|.   ..|   .. . |. | . |   |. .. .| .  .. . |. | .| || |||. ||.| |  ...  .| . .    .. 
nenlpitlkklykeeglayiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfll
0048567 (Phosphotyrosine protein) phosphatases II 91-169 4.5e-08 27.6 In-house 52-135 (157) alignment 
Range on Protein: 91-169
Range on HMM: 52-135/157.0
PVENIIRFFPMTKEFIDGSLQMGGKVLVHGNAGI---SRSAAFVIAYIMETFGMKYRDAFAYVQERR--FCINPNAGFVHQLQE
..  ..||. . ..|..     |... ||  ||    .|.| .. .|..  .|.  ..|.|...  |  . . . |.... |..
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslyn
PTPc_DSPc_SM00012 91-174 4.2e-07 25.5 In-house 19-100 (105) alignment 
Range on Protein: 91-174
Range on HMM: 19-100/105.0
PvENIIRFFPMTKEFIDGSLQmGGKVLVHGNAGISRSAAFVIAYIMETFGMKYR---DAFAYVQERRfciNPNAGFVHQLQEYEAIY
. ..|....  .|..   | . .. |.||  ||..|.. || ..|.    .| .   | | .|.| |   .  .| | ....|  .|
s.dsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelr...kqRpgmvqteeqylfly
subfamily_MSG5_pd Subfamily MSG5 96-174 9.4e-16 51.4 In-house 82-160 (165) alignment 
Range on Protein: 96-174
Range on HMM: 82-160/165.0
IRFFPMTKEFIDGSLQMGGKVLVHGNAGISRSAAFVIAYIMETFGMKYRDAFAYVQERRFCINPNAGFVHQLQEYEAIY
.. ..   . |  .   . |.||| . |.||||....||||  ...  |||.  .. .   |.|. |.. || |.|.. 
vkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweval