Gene STYXL1 in Homo sapiens

Synonym: DUSP24, MK-STYX, STYXL1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily STYXL1
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP045_AA protein Get Run
HsapP045_AA_157-302 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 31-135 2.9e-08 26.2 Pfam-A 14-111 (113) alignment 
Range on Protein: 31-135
Range on HMM: 14-111/113.0
LCLLDVRSKWEYDESHVITALRVKK----KNNEYLLPESVDLECVKYCVVYDNNSSTleILLKdddddsdsdGDGKDLVPQAAIEYGRILTRLTHHPVYI
. ||||||. ||...|.  |. |      ....   ..    |. ..    |..     ..             |..    ||.    || .| .  ||.
vvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdktv..vvyc.........rsgnrsggaaalllalilkelgyknvyv

LKGGYERFS
|.||.| ..
LdGGfeawk
subfamily_MKPLT_pd Subfamily MKPLT 141-303 7.8e-28 91.1 In-house 2-163 (164) alignment 
Range on Protein: 141-303
Range on HMM: 2-163/164.0
LRTQKIIWMPQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDAdKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGS
| |.. .   ..   .. ||  ... ... || ..| . |. |||||.  |||| ..   |.    . | ...|| .. |. .|| .. .|.    . | 
LitdldvrdeeDykrikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksv.eYlqvkvedesdeqlssfleraakfladaidsGG

VILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTILGD
 .|.  .|| ||| .. .|.|..|.  ||. .. |.|. .  . ||||.. || ..|. ||| 
rvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGk
subfamily_MKPLV_pd Subfamily MKPLV 141-303 7.8e-28 91.1 In-house 2-163 (164) alignment 
Range on Protein: 141-303
Range on HMM: 2-163/164.0
LRTQKIIWMPQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDAdKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGS
| |.. .   ..   .. ||  ... ... || ..| . |. |||||.  |||| ..   |.    . | ...|| .. |. .|| .. .|.    . | 
LitdldvrdeeDykrikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksv.eYlqvkvedesdeqlssfleraakfladaidsGG

VILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTILGD
 .|.  .|| ||| .. .|.|..|.  ||. .. |.|. .  . ||||.. || ..|. ||| 
rvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGk
0041856 (Phosphotyrosine protein) phosphatases II 144-302 2.6e-19 64.9 In-house 8-174 (182) alignment 
Range on Protein: 144-302
Range on HMM: 8-174/182.0
QKIIWMPQELdafqpYPIEIVPGkVFVGNFSQ--------------ACDPKIQKDLKIKAHVNVSmDTGPFFAGDAD---KLLHIRIEDSPEAQilpfLR
..|..... .     .. .| .. ...|.. .              |.. .  |.|.|.. ||.. .   .     .   ..|.. ..| .       |.
sdilpydhsr.....dldyInan.lylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpd....ld

HMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKN--NMCPNRGLVSQLLEWEKTILG
....|||. .. | ..|.  . |..|... ..||||.... .|.  ...|.....    .|| . . ||...|.  |.
elldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllk
0044763 (Phosphotyrosine protein) phosphatases II 146-302 3.9e-29 96.9 In-house 9-172 (178) alignment 
Range on Protein: 146-302
Range on HMM: 9-172/178.0
IIWMPQELDAFQPYPIEIVPGkVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDA--------DKLLHIRIEDSPEAQILPFLRHMCHFIEIHH-
........ ...... ||.|| ...|.. .|.|..  |.|.|.. ||.. .. ..| ..          . ||| |.|... ..| ... ...||| .. 
lsnleglersdyinaseilpg.lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeald

HLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNnMCPNRGLVSQLLEWEKTILG
  |...|.  . |..||.. ..||||...  .|.  ...|..... ..||.| . ||.|.|. .|.
ekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk
subfamily_DSP1_pd Subfamily DSP1 148-301 4.2e-26 86.0 In-house 4-157 (163) alignment 
Range on Protein: 148-301
Range on HMM: 4-157/163.0
WMPQELDAFQPY-PIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGdADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFS
|.  .||  . | |.|..   ...|  ..| . .| |.|.| | .||| ..  .|     .  .. .||||.|.|   .... .||.  .. .  .||  
wlgcdldklklydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfed.lfeYkklkleDspkadislvfeeviefidevkkknGkvlihC

TQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTIL
 .||||| . ..||||.... .|.  . .||. .. . || | | |||..||..|
qaGisRsstlclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll
subfamily_STYXL1_pd Subfamily STYXL1 150-303 2.3e-78 254.9 In-house 1-156 (157) alignment 
Range on Protein: 150-303
Range on HMM: 1-156/157.0
PQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDAD--KLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFST
|.|||....||.|..|||...||..||..|.|.||||.|||||||||.....||.||  |||||..||..||..|..|.....|||.|.. |.|.|.||.
preldelktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsn

QGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTILGD
.|||||.|.||||||.|...||.....|.||||.|..|||..|.|| ||||..||.
kGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllge
0046846 (Phosphotyrosine protein) phosphatases II 153-300 1.1e-12 43.6 In-house 77-172 (176) alignment 
Range on Protein: 153-300
Range on HMM: 77-172/176.0
LdafqpypieivpgkvfvgnfsqacdpkiqkdlkikahvnvsmdtgpffagdadKLLHIRIEDSPEAQIlPFLRHMCHFIEIHHHLGSVILIFSTQGISR
.                                                     . ||. ..|    ..   | ... ||. . . | ..|.    ||.|
i.....................................................qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigR

SCAAIIAYLMHS-NEQTLQRSWAYVKKCKN-NMCPNRGLVSQLLEWEKTI
... ..|||... .  ...   |.|....  .. .... . .| |.|. .
tgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 156-298 4.9e-25 81.8 In-house 3-145 (148) alignment 
Range on Protein: 156-298
Range on HMM: 3-145/148.0
FQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCA
 . .| || .. .|.|.  .| | .  |.| . . || . .    ..  . . ||....| |. ..  .  ..  |.. ..  |  .|.  . |.||| |
LrtfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssa

AIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEK
  ...|.. .. .|..  |.||  .. . || | ..|| |.|.
lallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_DSP6_pd Subfamily DSP6 157-300 1.4e-24 80.4 In-house 11-154 (158) alignment 
Range on Protein: 157-300
Range on HMM: 11-154/158.0
QPYPIEIVPgKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDA-DKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCA
. .|.||.|  ...|.  .|.. .. |.||||  .||  .   .|. .   | |.| |||  ....  |.    .||.  ..  | .|.    ||||| .
aefpveilp.llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

AIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTI
 ..||||.... .|. ....||| | |. ||  .. |||..|...
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfersl
0048076 (Phosphotyrosine protein) phosphatases II 158-300 4.9e-25 83.3 In-house 2-142 (145) alignment 
Range on Protein: 158-300
Range on HMM: 2-142/145.0
PYPIEIVPGkVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDAdKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAI
..|.||.|| ...|..  |.| .  |||.|.. .|.....  ... .  ..|.. ..| .. ..| .|.....||| ..  | ..|.. . |..|... .
ywpseilpg.lylgslptaldlellkdlgittvlnltselellerlgi.qylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlv

IAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTI
.||||...  .|.  ...|...  ...|| | . .|.|.|. .
aaylmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 158-299 1.9e-24 81.4 In-house 2-143 (144) alignment 
Range on Protein: 158-299
Range on HMM: 2-143/144.0
PYPIEIVPGkVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDAD-KLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAA
..|.||.|| ...|..  |.| .  |.|.|.. .|.. .  | | ..   ..||. ..| .  ..| .|.....||| ..  | ..|.  . |..|... 
snpseilpg.lylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtl

IIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKT
..||||. .  .|.  .|.|...  ...||.| . .|||.|| 
vaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyekl
0049772 (Phosphotyrosine protein) phosphatases II 158-299 5e-20 67.9 In-house 124-272 (314) alignment 
Range on Protein: 158-299
Range on HMM: 124-272/314.0
PYP---------------------IEIVPGKVfvgNFSQACDPKIQKdlkikahvnvsM---DTgPFFAGDADKLLHIRIEDsPEAQILPFLRHMCHFIE
...                     . |..|.    |.  |.|..  |               |  ..| .   |.|.| ..| ..| .| .......|||
ivmsrdevladelsrLdaAlgKtpllildgng...neptaadlellk...........eelydp.elferlgikylripvpD.gsaplledfdeflefie

IHhHLGSVILIFSTQGISRSC-AAIIAYLMHSNEQTLQRSWAYVKKCKNnMCPNRGLVSQLLEWEKT
 . . |...|.  . |..|.. ....||||. .  .|.  ...|...   ..||.|.. ||...|. 
ea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefi
PTEN_1 159-296 7.6e-09 30.7 In-house 42-187 (196) alignment 
Range on Protein: 159-296
Range on HMM: 42-187/196.0
YpieIVPGKVFVGNFSQA-CDPKIQKDLKIKAHVNVSMDTGP-FFAGDAD-------KLLHIRIEDSPEAQILPFLRHMCHFIEIHH-HL-GSVILIFST
     .......|. ... .| . .|  .| ..||.| .     . .| .       . ||. ||| .   .  ...  . |||    .  | |.|.. .
q...eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCk

QGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEW
.|..||   ..||||...  | .  ...|...  ...|| .   .||| 
aGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlley
subfamily_DSP10_pd Subfamily DSP10 160-300 1.1e-24 81.2 In-house 13-153 (159) alignment 
Range on Protein: 160-300
Range on HMM: 13-153/159.0
PIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIA
|.  |   .|.|.  .| | .. . |.|.| .||  ..  .|...| |  .| ..|. . ..     .  .|||  .. || .|.    |||||.. .||
pasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvvia

YLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTI
|||.  ...|. .. .||...  . || . . ||||.||..
YlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekel
subfamily_LRR-DSP_pd Subfamily LRR-DSP 160-301 4e-21 69.3 In-house 120-259 (263) alignment 
Range on Protein: 160-301
Range on HMM: 120-259/263.0
PIEIVPgKVFVGNFSQACDPKIQKDLKIKaHV-NVSMDTGPFFAgDADKLLHI-RIEDSPEAQILPFLRHMCHFIEIHHHLGSViLIFSTQGISRSCAAI
| ||.. |.|.|    | .  | ||| .  |.     |  |.|  .  | | |  ||| .||.|  .....  |||   . | | |.    |.|||....
Pdeiid.klflGgldsannksilkdlgvt.hillavadfePlfP.klfkylsiddiedvdeadisqhfeetnafieeGrkkGGv.lvhcraGvsrsstlv

IAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTIL
|.|||. .. .....   |.| .... ||.|.. ||. .|| . 
isylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
0051429 (Phosphotyrosine protein) phosphatases II 160-300 1.9e-06 23.3 In-house 16-224 (272) alignment 
Range on Protein: 160-300
Range on HMM: 16-224/272.0
PIEIVPGKVFVGNFS---QACDPKIQKDLKIKAHVNVSMDT-----GPFFAGDADKLLHIRIEDSPEAQILPFL--------------------------
  ...||... ...     | | .  |.|.||. |..  ..     . ..     ..||. |.|. . .|| .                           
grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltllls

----------------------RHMCHFIEIHHHlGSVILIFSTQGISRSCAAIIAYLMHsNEQT--------------LQRSWAYVKKCKNNMCPNRGL
                        .....|. .. |  .|.  . |..|.  .. ..|.     .              |.. .......  .. .. . 
agearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeq

VSQLLEWEKTI
. .|.|... .
ylflyeallel
subfamily_DSP19_pd Subfamily DSP19 161-300 7.4e-26 85.3 In-house 12-150 (152) alignment 
Range on Protein: 161-300
Range on HMM: 12-150/152.0
IEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDAdKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAY
.  |  ....|  . | | .| |  ||   .||....  .|. |  . |.| | | ||...| .|...  |||  ..   ..|.    |.||| . .|||
vgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdf.tylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviay

LMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTI
||...| .|...  .|.. . ...|| | . || |.|...
lmkkeelsleealelvrearpcikPneGFikqLkeyeael
subfamily_DSP3_pd Subfamily DSP3 162-299 1.9e-16 54.1 In-house 12-156 (162) alignment 
Range on Protein: 162-299
Range on HMM: 12-156/162.0
EIVPGKVFVGNFSQACDPKIQKDLKIKAHVNV------SMDTGPFFAGDAD-KLLHIRIEDSPEAQILPFLRHMCHFIEIH-HHLGSVILIFSTQGISRS
. |  |..||. . | | .  | | |   .|       ..|||. |  |.. | | . ..|.||...  . ..  .||.   ..  . .|. ...|.|||
devypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRs

CAAIIAYLMHSNEQTLQRSWAYVKKcKNNMCPNRGLVSQLLEWEKT
 . ..|||| ... ||.     |.| | ...||.| . || | .. 
atlvlayLmirrkmtlveairtvrk.kReilPneGFlkqLaeldee
subfamily_STYX_pd Subfamily STYX 162-302 1.7e-14 47.3 In-house 14-159 (166) alignment 
Range on Protein: 162-302
Range on HMM: 14-159/166.0
EIVPGkVFVGNFSQACDPKIQKDLK--IKAHVNVSMD-----TGPFFAgDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSC
||.|| .|.| .| |   |...  |  |   | .  .       | |  |  . | . . |..  .|. .| .. .||.   . |  .|.    |||||.
eilpg.lflgpysaamksklevlkkhgithivcirqnieanlikpnfp.drfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsa

AAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTILG
| .|||.| .     . ..|||.. .  . || |.|||| |.|   | 
alviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiyla
0051082 (Phosphotyrosine protein) phosphatases II 162-285 3.7e-09 31.9 In-house 9-138 (151) alignment 
Range on Protein: 162-285
Range on HMM: 9-138/151.0
EIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDT-----GPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHL-GSVILIFSTQGISRSCA
  | | ......  | . .  |.|.||. ||.  ..       ..     ..||| |.| |. ..  ..  . .|.|.  .  . ..|.  . |..|. .
syvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

AIIAYLMHsNEQTLQRSWAYVKKCKN-NMCP
 ...|||.    .|.  .......     .|
lvalylml.lgvsleealeeyrlkrpgvvqp
PTPc_motif_SM00404 163-298 6.1e-24 79.5 In-house 4-139 (140) alignment 
Range on Protein: 163-298
Range on HMM: 4-139/140.0
IVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLM
 . .....|. |.| .|...| |.|.. .||..      .    ..|.| ..|. .......|. .  |||  .  |  .|.. . |.||| . ||||||
rilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlm

HSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEK
.... .|. .. .||. .....|| ..| ||.|.||
ryrqlslaeayefvkerRpiispnlnfvrqLieyek
subfamily_DSP15_pd Subfamily DSP15 163-303 8.3e-17 55.7 In-house 5-142 (151) alignment 
Range on Protein: 163-303
Range on HMM: 5-142/151.0
IVPGkVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGdaDKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLM
..|| ...||| .. | .  |. .|   ..|. .. ...     . . |...|.|.|..  |..   .||      .  .|.    |.|||   ..||||
vlpg.lylgnfrdskdeelLkeknithilsvhdnakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlm

HSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTILGD
   |   . .   .|...    || |  .|| |.||| | .
tvtelnwrdalevikaaRsvanPnfGfkrqlkeyektklke
subfamily_DSP12_pd Subfamily DSP12 164-299 6.4e-22 72.6 In-house 5-142 (155) alignment 
Range on Protein: 164-299
Range on HMM: 5-142/155.0
VPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLL--HIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYL
. .....|. ... ... .|.|||.. . |   . | .  .. |.   .| | |.||. || .| ....|||   . .  .|.  . |.||| ...||||
ilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYl

MHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKT
|....  |..    ||. |....|| | ..||  .|| 
mkkeklslekAlklvkekkpeiepNegFleQLklfekm
0042113 (Phosphotyrosine protein) phosphatases II 164-299 8.6e-11 37.2 In-house 50-241 (245) alignment 
Range on Protein: 164-299
Range on HMM: 50-241/245.0
VPGKVFVGNFSQACDPK----IQKDLKIKAHVNVSMDT---------------------------------------------GPFFAGDADKLLHIRIE
...|...... .. ...      ..|.|.. |... ..                                             | ..      .... ..
itpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwp

DSPEAQILPFLRHMCHFIEIHHH--LGSVILIFSTQGISRSCAAIIAYLM-----HSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKT
| ... .|  |  ...|.. . .   . ..|. .. |..|... |.||||     .  . .|.   ....... ..... .   .| |... 
dhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_DSP8_pd Subfamily DSP8 165-300 7.2e-21 68.4 In-house 19-154 (159) alignment 
Range on Protein: 165-300
Range on HMM: 19-154/159.0
PGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHS
  ....|   .. . .. ..| |   .|.|.          .|.|.. ..|. . ..||.. . ..||.  ..  . .|..   ||||| . .|||.|. 
lknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimkt

NEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTI
 | .|. .. .||. .. . ||   . ||||.||..
lemsldeayrfvkekrptispnlnflgqLleyekel
subfamily_DSP14_pd Subfamily DSP14 167-309 9.7e-25 81.3 In-house 13-153 (157) alignment 
Range on Protein: 167-309
Range on HMM: 13-153/157.0
KVFVGnFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDADkLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNE
. |..  . | ...  |  || . .||....    . | .  .....||.|||.. ... ...  ||  .. |  .|.. . |.||| .  .||||. ..
sLfls.gvaalskellkkkkitliinvtvelpntklkdie.rvkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyek

QTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTILGDSITNIM
 .|. .. .||.... ..|| |  .|| ..|| . |.|  ...
lsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvkmv
subfamily_Slingshot_pd Subfamily Slingshot 167-298 2.3e-20 66.6 In-house 25-155 (169) alignment 
Range on Protein: 167-298
Range on HMM: 25-155/169.0
KVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFAGDAdKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNE
 |..|    |.. .  |. ...  .||. .   ||...  . |.||. |..|...|..  .  .|||  .. || .|.    |.||| ...||| |.. .
hvylGsewnasnleelkengveyilnvtkeidnffpekf.eylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyg

QTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEK
 .|.....|||. .. . ||.|...|| |.| 
lsleealeyvkerrsvikPnkgflkqleeyeG
DSPc Dual specificity phosphatase, catalytic domain 168-298 8.3e-24 79.0 Pfam-A 1-132 (133) alignment 
Range on Protein: 168-298
Range on HMM: 1-132/133.0
VFVGNFSQACdPKIQKDLKIKAHVNVSMDTGP--FFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSN
...|. |.|  ......|.|.. .||.. .    ...    . |.| .||. |..| ..|. .  |||  .  |  .|.  . ||||| . |||||| ..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

EQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEK
. .|.  ...||. .....|| |.. ||||.|.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 168-298 8.3e-24 79.0 In-house 1-132 (133) alignment 
Range on Protein: 168-298
Range on HMM: 1-132/133.0
VFVGNFSQACdPKIQKDLKIKAHVNVSMDTGP--FFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSN
...|. |.|  ......|.|.. .||.. .    ...    . |.| .||. |..| ..|. .  |||  .  |  .|.  . ||||| . |||||| ..
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

EQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEK
. .|.  ...||. .....|| |.. ||||.|.
nlslneAyefvkerrskispnagflrqLleyer
0049260 (Phosphotyrosine protein) phosphatases II 169-298 8.5e-13 43.7 In-house 16-147 (152) alignment 
Range on Protein: 169-298
Range on HMM: 16-147/152.0
FVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFFA--GDADKLLHIRIEDSPEAQILPFLRHMCHFIEI-HHHLGSVILIFSTQGISRSCAAIIAYLMHsN
..|. . | . .  |.|.|.. |..  ..   .       . ||. ..|..  ..  .|. ...|||.  .. | ..|.  . |..|. . ..||||. .
gpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.l

EQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEK
  .|.   |.|........|| |   .|.|.||
gvsleeavalvrekRpgavpnpgqlrflyefek
0043147 (Phosphotyrosine protein) phosphatases II 171-300 6.3e-13 44.3 In-house 29-160 (172) alignment 
Range on Protein: 171-300
Range on HMM: 29-160/172.0
GNFSQACDPKIQKDLKIKAHVNVSmDT---GPFFAGDADKLLHIRIEDSPEAqILPFLRHMCHFIEI--HHHLGSVILIFSTQGISRSCAAIIAYLMHsN
...  | . .  |.|.|.. ||.  .    ....     ..|.. ..| .   .| .|.....||.   .   | ..|.  . |..|... ..||||.  
lrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.l

EQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTI
  .|.   |.|.........| .   .|...||..
glsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 176-299 6.4e-07 22.6 In-house 14-140 (145) alignment 
Range on Protein: 176-299
Range on HMM: 14-140/145.0
ACDPKIQKDLKIKAHVNVSM---DTGPFFAGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRS
| |  . ..| |   ||..     .     ..  ..| |  ||    ..   .  .  ||.  .  |. ...    |.||| .  .|.||.  . ||  .
andvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlsea

WAYVKKCKNNMCPNRGLVSQLLEWEKT
   |.  .   .||  .. .||. || 
arqvrsnrllaypnvtflknllnlekq
subfamily_MSG5_pd Subfamily MSG5 178-300 1.1e-14 47.9 In-house 39-160 (165) alignment 
Range on Protein: 178-300
Range on HMM: 39-160/165.0
DPKIQKDLKIKAHVNVSMDTGPF-FAGDADKLLHIRIEDspEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYV
.||... | .   .||. .   . .   | |  ||. |   ...|   | .. . |   .  .  ||.    |.||| . |.||.|.  . .|. ..  .
epklkellsfdlvinvakeindlellvpavkyyhieweh..dskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydkl

KKCKNNMCPNRGLVSQLLEWEKTI
|   ... |. ||. ||.||| ..
ksvaddispsiglifqlmeweval
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 187-300 7.6e-17 55.1 In-house 29-152 (154) alignment 
Range on Protein: 187-300
Range on HMM: 29-152/154.0
IKAHVNVSMDTGPFFAGD--------ADKLLHIRIEDSPEAQILPFLRHMCHFIEIHH--HLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYV
||  .||.. .   |. .          . |.... | .. .|.  |    .||.        . .|. | .|.|||.| .|.|||.. . .|  .   .
iksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalell

KKCKNNMCPNRGLVSQLLEWEKTI
|...  . ||.|.. ||  .||  
kdsryiikPnqGflkqleifekel
0036282 (Phosphotyrosine protein) phosphatases II 201-299 2.4e-10 35.9 In-house 65-168 (174) alignment 
Range on Protein: 201-299
Range on HMM: 65-168/174.0
FAGDADKLLHIRIEDSPEAQILPfLRHMCHFIEIHHHL--GSVILIFSTQGISRSCAAIIAYLMHSNEQ-TLQRSWAYVKKCK---NNMCPNRGLVSQLL
.     ..|.. ..|  .  .   |.... |.| ..    | ..|.  . |..|. . ..||||. .   .|.  ...|....    .|... .   .| 
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfly

EWEKT
..|| 
yfekl
0037934 (Phosphotyrosine protein) phosphatases II 205-299 1.2e-11 40.1 In-house 135-240 (243) alignment 
Range on Protein: 205-299
Range on HMM: 135-240/243.0
ADKLLHIRIED----SPEAQILPFLRHMCHFIEI-----HHHLGSVILIFSTQGISRSCAAIIAYLMHSN-EQTLQRSWAYVKKCKNN-MCPNRGLVSQL
  ..... . |    .  ...| ||.... |||      . . |...|.  . |..|. . |.||||... . .|.  .......... ......   .|
vihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfl

LEWEKT
 |... 
yealle
0040439 (Phosphotyrosine protein) phosphatases II 206-299 9.3e-13 43.8 In-house 140-244 (249) alignment 
Range on Protein: 206-299
Range on HMM: 140-244/249.0
DKLLHIRIEDSPEAQILPFLRHMCHFIEIHHH------LGSVILIFSTQGISRSCAAIIAYLM-----HSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLL
 . |||.. | |. .. |.. ... |||. ..       |...|. .. |..|... |.||||     . .. .|.  .............| .   .|.
rtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfly

EWEKT
|... 
ealle
0045450 (Phosphotyrosine protein) phosphatases II 207-299 2e-12 42.9 In-house 179-302 (307) alignment 
Range on Protein: 207-299
Range on HMM: 179-302/307.0
KLLHIRIEDS-----------------PEAQILPFLRHMCHFIEIHHH------LGSVILIFSTQGISRSCAAIIAYLMHSNE--------QTLQRSWAY
........|.                 |. .. |.. ....|||. ..       |...|. .. |..|... |.|||| ..          .|.  ...
tvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkl

VKKCKNNMCPNRGLVSQLLEWEKT
..... ....| .   .| |... 
lreqRpgavqnpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 207-301 4.6e-12 41.3 In-house 157-276 (317) alignment 
Range on Protein: 207-301
Range on HMM: 157-276/317.0
KLLHIRIEDS----------------PEAQILPFLRHMCHFIEIHHHL----GSVILIFSTQGISRSCAAIIAYLM-----HSNEQTLQRSWAYVKKCKN
.|.....||.                |.  . | .... .|.|. ..     |...|. .. |..|... |.||||     . .. ...  .........
tlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRp

NMCPNRGLVSQLLEWEKTIL
..... .   .| ...  .|
gavqtpeqyrflydalleyl
0036941 (Phosphotyrosine protein) phosphatases II 207-300 1.1e-10 36.7 In-house 169-276 (297) alignment 
Range on Protein: 207-300
Range on HMM: 169-276/297.0
KLLHIRIEDSPEAQILPFLRHMCHFIEIHHH------LGSVILIFSTQGISRSCAAIIAYLM--------HSNEQTLQRSWAYVKKCKNNMCPNRGLVSQ
.. |. . . |.  . .  ... .|||  ..       |...|. .  |..||.. |.|.||        . .. ..   . ............ .   .
tvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrf

LLEWEKTI
| |..   
lyeallel
subfamily_PTPMT1_pd Subfamily PTPMT1 207-297 8.9e-08 26.8 In-house 75-165 (171) alignment 
Range on Protein: 207-297
Range on HMM: 75-165/171.0
KLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWE
. |.... |  ||  |  | .  .||| ....|. . .    | .|| . ...|||.... ...  . ..||... .  ..  ...| |.|
eqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeye
0051299 (Phosphotyrosine protein) phosphatases II 208-286 1.3e-06 23.6 In-house 184-271 (288) alignment 
Range on Protein: 208-286
Range on HMM: 184-271/288.0
LLHIRIEDSPEAQILPFLRHMCHFIEIHHHL----GSVILIFSTQGISRSCAAIIAYLM-----HSNEQTLQRSWAYVKKCKNNMCPN
  |.   . |. .. . .... .|... ..     |..... .  |..|... |...|.     . .. .. . ..........|...
vthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt
0050432 (Phosphotyrosine protein) phosphatases II 208-286 6.9e-06 21.1 In-house 199-284 (308) alignment 
Range on Protein: 208-286
Range on HMM: 199-284/308.0
LLHIRIEDSPEAQILPFLRHMCHFIEIHHHL--GSVILIFSTQGISRSCAAIIAYLM-----HSNEQTLQRSWAYVKKCKNNMCPN
. |.   . |. .. | .... .|.|. ..   |..|.. .  |..|... |...|.     . .. ...  ..........| ..
vthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqt
0045098 (Phosphotyrosine protein) phosphatases II 209-299 1.5e-10 36.4 In-house 162-270 (278) alignment 
Range on Protein: 209-299
Range on HMM: 162-270/278.0
LHIRIEDSPEAQILPFLRHMCHFIEIHHH--------------LGSVILIFSTQGISRSCAAIIAYLMHSN---EQTLQRSWAYVKKCKNN-MCPNRGLV
|..   ..|.  || .. ... ||. ..                | ..|.    |..|... ..|||| ..     .|.   ......... ...| .  
lpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqy

SQLLEWEKT
 .| |..  
rflyeflle
0047943 (Phosphotyrosine protein) phosphatases II 209-293 8.7e-07 24.1 In-house 169-264 (273) alignment 
Range on Protein: 209-293
Range on HMM: 169-264/273.0
LHIRIEDSPEAQILPFLRHMCHFIEIHHH------LGSVILIFSTQGISRSCAAIIAYLM-----HSNEQTLQRSWAYVKKCKNNMCPNRGLVSQL
 |.   . |. .. | | .. .|||. ..       ...... .  |..|... |...|.     . .. ..   ........ .| ..     .|
thfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0039614 (Phosphotyrosine protein) phosphatases II 210-299 1.6e-09 33.1 In-house 187-287 (297) alignment 
Range on Protein: 210-299
Range on HMM: 187-287/297.0
HIRIEDSPEAQILPFLRHMCHFIEIHHH------LGSVILIFSTQGISRSCAAIIAYLM-----HSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEK
|.   . |. .. | |.....|.|. ..       | ..|. .. |..|... |.||||     .  . ...  .............. .   .| ....
hfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydall

T
 
e
0043336 (Phosphotyrosine protein) phosphatases II 218-297 1e-07 27.2 In-house 192-273 (278) alignment 
Range on Protein: 218-297
Range on HMM: 192-273/278.0
EAQILPFLRHMCHFIEihhHLGSVILIFSTQGISRSCAAIIAYLM-----HSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWE
 ...| ||. . ...|   . ....|. .. |..|... |..||.     .  . .|.  ........ .....     .| |..
lsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
0038934 (Phosphotyrosine protein) phosphatases II 221-302 8e-09 30.9 In-house 92-178 (194) alignment 
Range on Protein: 221-302
Range on HMM: 92-178/194.0
ILPFLRHMCHFIEIH-----HHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVSQLLEWEKTILG
  | |  ...|...       . | |...  . |..|.   ..|||....  ... . |... ..... ||.. ...||.. |..  
tvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykelrk