Gene MTMR14 in Homo sapiens

Synonym: C3orf29, MTMR14

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR14
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP052_AA protein Get Run
HsapP052_AA_244-406 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0040695 (Phosphotyrosine protein) phosphatases II 53-431 1.7e-55 182.3 In-house 9-348 (388) alignment
Range on Protein: 53-431
Range on HMM: 9-348/388.0
KVERIEKRCLEL-FGRDYCFSVIPNTNGDICGHYPRHIVfleyessekekdtfestVQVSKLQDLIHRSKMARCRGRFvcPVILF----KGKHICRSATL
 .  |....  | .|.|... .| | |...|..||...|                 |..|  ..|. |.   |..||.  ||...    .|....||...
slydilrelkrlglgldlwrisivNenyelcpsYPallv.................VPksisdellkrvarfrskgri..PvlsyrhpnngavllRssqp

AGwgelygrsgynyffsggaddawadvedvteedcALRSGDTHLFDKVRGYDIKLLRYLSVKYICDLMvenKKVKFGMNVTSSEKVDKAQRYADFTLLSI
 .                                  |  .. . ..|......|||. ||. .|.||.   .|... .|......|.. ..|....|...
lv.................................glllsrsledeklleailkllpnlskllivdlr...pklnalanralgggvenedaypnaelifl

PYPGCEFFKEykdrdymaeglifnWKQDYVDAPLSIPDFLthSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNsDDDSGLLVHCISGWDRTPLFISLLRLS
..|......|              . |...|| |..||.|  .|.. ..... .||.........|...|.. ...|..||||..|||||....||..|.
nipnihvvre..............slqklldaclnvpdsl..nllslleesgwldliklilelavlivklld.lgnssvlvhcsdgwdrtsqlssLaqll

LWADgliHTSLKPTEILyltVAYDWFLFGHMLVDRLSKGEE---------------------------IFFFCFNFLKHITSEEFSAL--------KTQR
|...   . .|.   .|   ....|..|||.. |||. .|.                           .|.|....|.... . .| .        ...|
ldPy...YRTleGFqvL...iekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnseker

RKSlPARDGGFTLEDICML
...   .. ...| .... 
lel.svsertlslwsylls

subfamily_MTMR14_pd Subfamily MTMR14 59-411 1.8e-179 588.1 In-house 1-356 (357) alignment
Range on Protein: 59-411
Range on HMM: 1-356/357.0
KRCLELFGRDYCFSVIPNTNGDICGHYPRHIVFLEY---ESSEKEKDTFESTVQVSKLQDLIHRSKMARCRGRFVCPVILFKGKHICRSATLAGWGELYG
|...||. |||..||| ||||..|..||.....|||   |.||.||...||...|..|..|....|.|||| |||.||||..||.|||||||. ..|.||
kkveellkrdyslsvidntnGelcsrypvkllileyelgegsegekelvesaydvqrlrelltkakyarcrerfvvpvilldgknicrsatlsvaaeiyg

RSGYNYFFSGGADDAWA--DVEDVTEEDCalRSGDTHLFDKVRGYDIKLLRYLSVKYICDLMVENKKVKFGMNVTSSEKVDKAQRYADFTLLSIPYPGCE
|||.||..|||......  |.|..|...   .. ...|.|.||..|||||..|.||.|.|||||.||||.|..|.||||.||..||.||||||.||||.|
rsGlnylasggeeadadkedeelitaked..qaeeqalldrvrksdikllktlkvklivdlmvekkkvkyglavsssekadkekrykdftllslPyPGve

FFKEYKDRDYMAEGLIFNWKQDYVDAPLSIPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLSLWADGL
|||...|..|.|. |..|||||.||| |.||| |..|..||||.|..||||..|||||||||..|..|.||||||||||||||||||.||||||||||||
ffkkfrdnkysaknlfynWkqdevdaelniPdklaasvdidwseykkWdlvaltqnylklllkyvkededsGllvhcisGWdrtPlfvsllrlslWadgl

IHTSLKPTEILYLTVAYDWFLFGHMLVDRLSKGEEIFFFCFNFLKHITSEEFSALKTQ
||.||...|.||||||||||||||.|.|||.|||||.||||..||.||||||| |.|.
ihqslsaaellyltvaydWflfghqlpdrlkkgeeilffcfdvlkfitseefsiletr

0051082 (Phosphotyrosine protein) phosphatases II 198-347 2.7e-09 32.3 In-house 24-116 (151) alignment
Range on Protein: 198-347
Range on HMM: 24-116/151.0
YDIKLLRYLSVKYICDLMVENKKVKFGMNVTSSEkvdkaqryadftllsipypgceffkeykdrdymaeglifnwkqdyvdaplsipdflthslnIDWSQ
 ...||. | .|.|..|. |    ..   ... .                                                             |.. .
dflellkelgiktivnlrseeergycpeylpelg.............................................................ievlh

YQCWDLV----QQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRLS
....|      ..... .. .|.|......  .|||| .|..|| ... |... 
ipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylml

0051429 (Phosphotyrosine protein) phosphatases II 199-351 5.5e-09 31.6 In-house 37-178 (272) alignment
Range on Protein: 199-351
Range on HMM: 37-178/272.0
DIKLLRYLSVKYICDLMVENKKVKFGMNVTSsekvdkaqryADFTLLSIPYPGCEFFKEYkDRDYMAEGLIFNWKQDYVDAPLSIPD--FLTHSLNIDWS
|.. |. | .|.|.||. |. . ...               .....| .|... ...      ...   | . .. ||.   | .      . .. . . 
dfwrlkelgiktivdLrseeErgrlkcdryw..........pgirylhlpilddsaptil.ygalrvtllseellldyilrellltlllsagearevmhl

QYQCWDLVQQTQNYLKLLLSLVNSddDSGLLVHCISGWDRTPLFISLLRLSLWAD
.|. |      |..|. ||.|...  .  .|||| .|.||| ... ||.| |  .
hytdwpdhgvpqeallellellld..ggpvlvHCsaGkdRTGtvvallllllgvs

0044763 (Phosphotyrosine protein) phosphatases II 199-343 6.6e-08 27.9 In-house 40-130 (178) alignment
Range on Protein: 199-343
Range on HMM: 40-130/178.0
DIKLLRYLSVKYICDLMVENKKVKFGMNVTSSEKVDkaqryadftllsipypgceffkeykdrdymaeglifnwkqdyvdaplsipdflTHSLNIDWSQY
|..||. | ...|..|  |    .....    |. .                                                      . |.| .. .
dlellkelgithivnlteelelgflkcdpywpeeag.....................................................iqylhipipDh

QCWDLVQQTQNYLKLLLSLVNsDDDSGLLVHCISGWDRTPLFISL
 . || ..... .... .... ....  ||||  |..|..... .
gvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaa

0045098 (Phosphotyrosine protein) phosphatases II 203-346 6.7e-07 24.5 In-house 84-229 (278) alignment
Range on Protein: 203-346
Range on HMM: 84-229/278.0
LRYLSVKYICDLM--VENKKVKFGMNVTSsekvDKAQRYADftlLSIPYPGCEFFKEYKDRDYMAEGL----IFNWKQDYVDAPL-SIPDFLTHSLNIDW
|. | ...|. |.  ||....|. .   .    .. ..| |   ... .  .| ...|  |... . |      . .       . ..||. ..||.| .
lwelgitvivmltelvelgrekcaqywpe....ggsltygd...ftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilk

SQYQCWDLVQQTQN--YLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRL
|  .... ... ..  . .||.||.  |..   ||||  |..||  .. .  .
sflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylm

0049260 (Phosphotyrosine protein) phosphatases II 259-345 1.1e-06 24.0 In-house 55-111 (152) alignment
Range on Protein: 259-345
Range on HMM: 55-111/152.0
KdrdymaeglifnwkqdyvdaplsipdfltHSLNIDWSQYQCWDLVQQTQNYLKLLLSLvNSDDDSGLLVHCISGWDRTPLFISLLR
                              . |.. |  . ..|| |  .  |...  | . |..   ||||  | .||.... .. 
i.............................qylhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaayl

0049772 (Phosphotyrosine protein) phosphatases II 262-349 1.1e-08 30.7 In-house 156-240 (314) alignment
Range on Protein: 262-349
Range on HMM: 156-240/314.0
DYMAEGLIFNWKqDYVDAPLSIPDFLTHSLNIDWSQyQCWDLVQQTQNYLKLLLSLvnsDDDSGLLVHCISGWDRTP--LFISLLRLSLW
..  .  . ..| . .. |   ..   . |.|...   ...| .. .  |......   |... .|||| .|..||.  ... .| . |.
neptaadlellk.eelydpelferlgikylripvpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllg

0046846 (Phosphotyrosine protein) phosphatases II 263-346 3.6e-06 22.4 In-house 77-132 (176) alignment
Range on Protein: 263-346
Range on HMM: 77-132/176.0
YmaeglifnwkqdyvdaplsipdfltHSLNIDWSQYQCWDLvQQTQNYLKLLLSLVNSDddSGLLVHCISGWDRTPLFISLLRL
.                         . |...|  ... || .. .. |... . ....     ||||  |  ||.... .. |
i.........................qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaayll

0048179 (Phosphotyrosine protein) phosphatases II 267-346 2.2e-07 26.3 In-house 48-106 (144) alignment
Range on Protein: 267-346
Range on HMM: 48-106/144.0
GlifnwkqdyvdaplsipdfLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNsdDDSGLLVHCISGWDRTPLFISLLRL
                     .. |...|  ... || .. .. |... ....  ..   ||||  | .||.... . ..
e...................giqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylm

0043147 (Phosphotyrosine protein) phosphatases II 281-344 3.7e-07 25.5 In-house 59-121 (172) alignment
Range on Protein: 281-344
Range on HMM: 59-121/172.0
LSIPDFLTHSLNIDWSQYQCWdLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLL
    ..  . | . |  . .  | .. .. |... .|.. ...   ||||  |..||.... ..
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaay

0036282 (Phosphotyrosine protein) phosphatases II 283-346 5.2e-08 28.3 In-house 65-127 (174) alignment
Range on Protein: 283-346
Range on HMM: 65-127/174.0
IPDFLTHSLNIDWSQYQCWDLVQqTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRL
  ..  . | . |  ... || .  .. .|.. . ...|..  .||||  | .||.... ....
lerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylm

0043336 (Phosphotyrosine protein) phosphatases II 283-346 5.6e-07 24.8 In-house 171-233 (278) alignment
Range on Protein: 283-346
Range on HMM: 171-233/278.0
IPDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNsDDDSGLLVHCISGWDRTPLFISLLRL
 . . ||   ..|  ... . ... ...|| ... .. |... .||||  | .|| .|| |..|
esrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyll

0042113 (Phosphotyrosine protein) phosphatases II 284-346 4.2e-08 28.4 In-house 137-199 (245) alignment
Range on Protein: 284-346
Range on HMM: 137-199/245.0
PDFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDDDSGLLVHCISGWDRTPLFISLLRL
. . .| . ..|  ... ||... .. |..... ...|..  .||||  | .|| .|| ....
srevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

0048076 (Phosphotyrosine protein) phosphatases II 285-345 4.9e-07 25.1 In-house 45-103 (145) alignment
Range on Protein: 285-345
Range on HMM: 45-103/145.0
DFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSDddSGLLVHCISGWDRTPLFISLLR
.. .. |...|  ... || .. .. |... ......     ||||  | .||.... .  
rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaayl

0037934 (Phosphotyrosine protein) phosphatases II 285-349 5.2e-07 25.0 In-house 133-204 (243) alignment
Range on Protein: 285-349
Range on HMM: 133-204/243.0
DFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNS-------DDDSGLLVHCISGWDRTPLFISLLRLSLW
 . .| . . |  ... | ... ...|. . . ...       |... .||||  | .|| ..| .. . | 
rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmlll

0039614 (Phosphotyrosine protein) phosphatases II 285-346 1.2e-06 23.7 In-house 183-245 (297) alignment
Range on Protein: 285-346
Range on HMM: 183-245/297.0
DFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSD-DDSGLLVHCISGWDRTPLFISLLRL
 ..|| . ..|  ... ..... .. |.|. . .... ..   ||||  | .||  || ....
rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylm

0045450 (Phosphotyrosine protein) phosphatases II 285-346 2.7e-06 22.8 In-house 195-257 (307) alignment
Range on Protein: 285-346
Range on HMM: 195-257/307.0
DFLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSD-DDSGLLVHCISGWDRTPLFISLLRL
 ..||   ..|  ... . .... . ...... .... ...  ||||  | .||. || .. .
rtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

0040438 (Phosphotyrosine protein) phosphatases II 286-346 9.2e-06 20.6 In-house 173-232 (317) alignment
Range on Protein: 286-346
Range on HMM: 173-232/317.0
FLTHSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNsDDDSGLLVHCISGWDRTPLFISLLRL
..||   ..|  . . .  .. .. |... .  . |... .||||  | .||  || ....
tvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylm

0040439 (Phosphotyrosine protein) phosphatases II 288-346 3.9e-07 25.4 In-house 143-202 (249) alignment
Range on Protein: 288-346
Range on HMM: 143-202/249.0
THSLNIDWSQYQCWDLVQQTQNYLKLLLSLVNSD-DDSGLLVHCISGWDRTPLFISLLRL
.|   .||  ... . .... ........ .... ... .||||  | .||..|| .. .
lhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

subfamily_MTMR3_pd Subfamily MTMR3 311-388 7e-09 27.9 In-house 255-328 (442) alignment
Range on Protein: 311-388
Range on HMM: 255-328/442.0
LKLLLSLVNS--DDDSGLLVHCISGWDRTPLFISLLRLSLwaDGLiHTSLKPTEILyltVAYDWFLFGHMLVDRLSKGEE
||  ...|..   .   .||||  |||||.  ..| .| |  |   . .|.  ..|   |  .|. ||| . || . ||.
lkaavkvveavdkegrpvlvhCsdGWdrttqivalaklll..dpy.yrtleGfkvl...vereWldfGhkfadrcghgen

subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 314-385 1.7e-07 22.8 In-house 214-278 (404) alignment
Range on Protein: 314-385
Range on HMM: 214-278/404.0
LLSLVNSDdDSGLLVHCISGWDRTPLFISLLrlSLWADGLIHTslkpTEILYLTVAYDWFLFGHMLVDRLSK
...|....  |  ||||. |||||.   ||    | .|    |     |  .  .  .|  |||. ..| ..
ivelieke.kssvlvhcsdgwDrtsqlssls..qllldpyyrt....iegFivliekewlsfGhkfaqRigq

Myotubularin-like phosphatase domain 314-386 1.9e-06 19.9 Pfam-A 220-288 (353) alignment
Myotubularin-like phosphatase domain 314-386 1.9e-06 19.9 In-house 220-288 (353) alignment
subfamily_MTMR1_pd Subfamily MTMR1 324-388 1.4e-07 23.1 In-house 213-271 (389) alignment
Range on Protein: 324-388
Range on HMM: 213-271/389.0
SGLLVHCISGWDRTPLFISLLRLSLwaDGLIHTsLKPTEILyltVAYDWFLFGHMLVDRLSKGEE
.  ||||  |||||  ..||  | |  |    | ..  |.|   .. .|  ||| . .||..|..
tsvlvhcsdGWDRtaqltsLamlll..DsyyRt.ieGfevl...iekeWlsfGHkfkeRlghgdk