Gene MTMR3 in Homo sapiens

Synonym: FYVE-DSP1, ZFYVE10, hCG_2011013, MTMR3

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR3
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP053_AA protein Get Run
HsapP053_AA_167-596 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Myotub-related Myotubularin-like phosphatase domain 139-539 1.4e-149 490.7 Pfam-A 1-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 139-539 1.4e-149 490.7 In-house 1-352 (353) alignment
subfamily_MTMR3_pd Subfamily MTMR3 144-591 3.7e-238 783.6 In-house 1-441 (442) alignment 
Range on Protein: 144-591
Range on HMM: 1-441/442.0
AYHAWCMEVyaSEKEQHGDLCRPGEHVTSRFKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGA
|||||..|.  .|||..| |.|.........|.||||.|||...|||||..|...||| |||..||||..|||..|..|.||||.||.|||..||..|||
ayhawklee..eekerdgfllraasvaeeklkeeverlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkknga

VIARCGQPEVSWWGWRNADDEHLVQSVAKACASDS--RSSGSKLSTRNTsrDFPNGGDLSDVEFDsslsnASGAESLAIQPQKLLILDARSYAAAVANRA
|.|||.||||.|.|||||.||.|....|||||.|.  ...|.|||....  .  ...| .|.|.|     ||..|||| ...||||.|||||.||.||||
vlarcsqPevgwlgWrnaedekllkaiakacaldagekakgeklsngka..kkkdvsdaldaead.....aseeeslaeekkkllivdarsytaafanra

KGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAK
||||||..||||||||||.|.||||..|.||.||| |..|.||. |||||||.||||..||||||.|. ||.|||...||||||||||||||.|||||||
kgGGceleeyypncevvflglanihavrksfnslrallsqspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalak

LLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKH
|||||||||.|||.||||.||||||||||||||||||.|| ||||||||||||.|||||||||.|||||||||||||||||||||||||.|..||| |..
llldpyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeek

TQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYLP
..|||.|||||||| .|...||||....||||.|...||.|.|||.|||.
vkertlsvWsllrakekeyrnllykekteavllpavsvrelklwsevyle
0040695 (Phosphotyrosine protein) phosphatases II 166-592 6.1e-151 496.3 In-house 5-385 (388) alignment 
Range on Protein: 166-592
Range on HMM: 5-385/388.0
PGEHVTSRFKNEVERMGFDMNnAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEH
   ...  ...|..|.|....  ||||..||.|.||.|||. |.||..|.|..|..|..|||..|||...|||. ||||. |..|| |.....|. .||.
eegwslydilrelkrlglgld.lwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledek

LVQSVAKACAsdsrssgsklstrntsrdfpnggdlsdvefdsslsnasgaeslaiQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANI
|.... |..                                              ...||||.|.|... |.||||.|||.|. ..|||.|..|... ||
lleailkllp.............................................nlskllivdlrpklnalanralgggvenedaypnaeliflnipni

HSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDF
| .|.|.|.|. .|...||  |.||.||...||......|..| |.|. .|... .||||||||||||.|...|| |||||||||.||||||.| ||| |
hvvreslqklldaclnvpdslnllslleesgwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsf

GHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLY
|||||||.||.|...| .|..||||..||||.||.||||..||||| .|. |..|.|||.|||||.|. ||| | ...|||.|.||.|   .. |.|.||
ghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkseflnplY

SSQSEAVLYPVCHVRNLMLWSAVYLPC
.. |. ||.|...|..|.||. .||..
dpsslevllpslsvldlllWleyylrw
subfamily_MTMR1_pd Subfamily MTMR1 174-276 3.5e-26 84.4 In-house 12-114 (389) alignment 
Range on Protein: 174-276
Range on HMM: 12-114/389.0
FKNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKA
...|.||.|   ...|||...|.||.|| .||. |.||. ..|..|. |..||| .|.| . . ...|.|||.|. || |   | |...||...| . .|
peaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskedekylqailea

CAS
 |.
naq
subfamily_MTMR6_pd Subfamily MTMR6 174-275 1.9e-22 72.1 In-house 24-123 (397) alignment 
Range on Protein: 174-275
Range on HMM: 24-123/397.0
FKNEVERMGFDmNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPeVSWWGWRNADDEHLVQSVAKA
 |.|..|||   |..| ....|..|.|| .||.|| ||. .| . | . | ||| .|.| . | |..| | | || || .|    |  .||.|.. . ||
lkaeytrmgvp.nekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqp.lsgfsarcledeklleairka

CA
 .
np
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 175-590 4.2e-128 419.9 In-house 22-400 (404) alignment 
Range on Protein: 175-590
Range on HMM: 22-400/404.0
KNEVERMGFDMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKAC
..| .|.|.  .  ||||.|| .|.|| .||. |.||  |.|.||..|.|||| .|||.. .||.|....|.|. || |   . |  .||.|..|. ||.
eeEykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplvGltksrseedEklinsirkak

ASDSrssgsklstrntsrdfpnggdlsdvefdsslsnasgaeslaiqpqKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQS
.. .                                             .|.|||||..| ||||.||| |.|  . | |||. |....|||..| |...
tqle.............................................tlyildarpkanavansakgagyedisryenceieflnienihelreslkk

LRLLCTQMPDP-GNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRC
|. ..... .   |||| |||..|| |.. ||...  .|. ..... .||||||||||||.|...|..|||||||||||||.||.| |||.||||||.|.
lkkavnsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRi

GHgENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLY---SSQSE
|. ... . .|| |.|||..|||.|| .||| |||||| ||.|.... ||| |||||... ||| ...... | |.|.|| | .. . | ||   .....
gq.ttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWalleankseylnplyilekkeqk

AVLYPVC-----HVRNLMLWSAVYL
      .     ..... |||  ||
enitssessssadikliklWseyyl
subfamily_MTMR9_pd Subfamily MTMR9 176-288 1.3e-24 79.0 In-house 29-128 (393) alignment 
Range on Protein: 176-288
Range on HMM: 29-128/393.0
NevermgfdMNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACa
           ..||||..|...|.| |||...|||. |.|.||. ...||.  |.|   |.|. ..||. |..|| ..  | |  .||.|...| |.  
s........asdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgssgkrckedekllnlvlkkl.

sdsrSSGSKLSTR
    . |. . ||
....kkGlivdtr
subfamily_pats1_pd Subfamily pats1 176-247 5.9e-07 20.2 In-house 13-82 (691) alignment 
Range on Protein: 176-247
Range on HMM: 13-82/691.0
NEVERMGFDMNNAWRISNINEKyKLCGSYPQELIVPAWITDKELESVSSFRSWKrIPAVIYRHQSNGAVIAR
 | .|.. |..  ||. .. .. .|.  ||.  .||  ..|. | |    || | || . . .|.| ... |
iegqrlkldldkdwrvveflsr.dlseiyPkrilvPklvsdellvsyvrkrssk.iPvlswsnqnnksslfr
subfamily_MTMR5_pd Subfamily MTMR5 177-252 2.4e-17 54.9 In-house 13-94 (483) alignment 
Range on Protein: 177-252
Range on HMM: 13-94/483.0
EVERMGFDM------NNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPE
. .|.|...      .. .|||..|.||..| |||  ..||  . |.... |.     .|.|.|..||. |.|.. | |..|
dykRlGlgalngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfe
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 185-276 4.5e-19 60.5 In-house 38-129 (405) alignment 
Range on Protein: 185-276
Range on HMM: 38-129/405.0
MNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSNGAVIARCGQPEVSWWGWRNADDEHLVQSVAKACAS
 |  |....|| .||.| ||.  |.| .  .||.|| . ||||  |||.. ..  |  | |.|| || |     |  .||  . |.| .. |
sncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqplvgierarcpedelycsslalsaps
subfamily_MTMR10_pd Subfamily MTMR10 185-276 3.1e-06 18.2 In-house 22-110 (380) alignment 
Range on Protein: 185-276
Range on HMM: 22-110/380.0
MNNAWRISNINEKYKLCGSYPQELIVPAWITDKELESVSSFRSWKRIPAVIYRHQSnGAVIARCGQPEVSwwGWRNADDEHLVQSVAKACAS
 ..|.. .. ||. . . ..|| ..||. ..|...| .|      | |  .. | . ||.  |... . .     . ..|. ..  ...| .
vsdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshak.gaallrlsalqea..esadkekeekmlelvrkchp
subfamily_MTMR5_pd Subfamily MTMR5 282-586 2.4e-64 209.9 In-house 163-476 (483) alignment 
Range on Protein: 282-586
Range on HMM: 163-476/483.0
GSKLSTRNTSRDFPNGGDLSDVEFDSSL--SNASGAESLAIQPQKLLILDARSYAAAVANrakgggcecpEYYPNCEVVFMGMANIHSIRRSFQSLRLLC
 ..|||..   |  ..   |. .  ..|   ||.  ..| .. ..| .|  .| . .|            | . ..|.. . . .|  ...||. |.  |
raalsteknaldisksdkasqggkgatlkennakeskklrarkaaLYvlgeksqlknvks..........evdskaefipvelveirqvkasfkkllraC

TQM-----PDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCG
.       ...  .|...|   ||. .| ||. .  ||  .| ..  |||   |||| | |...||.|||||||||.|||.|||| ||| |||.|..|. 
lpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkvLveKEWLafGHrFtkrsn

HGENSDDLnERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEK----------HTQERTCSVWSLLRAGNK---AFK
. ...       |||||.||||||..|||| .||||. .|  |  |  |. | ||| .  .|| |.          .... . |||  . . .|   .| 
qtlsaqss.gfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeekaekrakkagksvwdyidrqhkrspify

NLLYSSQSEAVLYPVCHVRNLMLWS
| |||.... || | ..| .| .|.
nflyspdesevlrPssnvsslkvWd
subfamily_MTMR1_pd Subfamily MTMR1 320-590 2e-111 365.0 In-house 113-384 (389) alignment 
Range on Protein: 320-590
Range on HMM: 113-384/389.0
IQPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQ
 | .||||||||| ..||||.|||.| |  |.| |.|..|. ..|||..| |.. |. |.    |  .|||||||||||.|....|..|  .|..|.. .
aqsekllildarssvnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvlpnvddkkwlsalestkWlehiklilagavkivekvetek

RPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQ
  |||||||||||| |...||.||||.||||||||.||.| ||| |||||..| |||...   .|| |||||..|||.||.||||. ||||| ||. |..
tsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlld

HTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQ-SEAVLYPVCHVRNLMLWSAVYL
| |||||||||.|. ||| ... .|.| |.|| . . .. |.| ||... .. ||||.. .|.| ||.  ||
hlysclfGtflfnsekervkekvkektvslwsyvnsskeeftnplyaeelekkvlypkaslrrlelWkeyyl
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 321-590 1.2e-68 223.7 In-house 128-402 (405) alignment 
Range on Protein: 321-590
Range on HMM: 128-402/405.0
QPQKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCT---QMPD-----PGNWLSALESTKWLHHLSVLLKSALLVV
  . | ..|||    |.|| |.| | |    |||| .||| . ||| ||.|.. | |      .  |        .   .| | |. |.  .|..| .  
psktlylidarpklnaiantangagfenihnypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksileaatfsa

HAVDQDqRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSDdlNERCPVFLQWLDCVHQLQRQFPCSFEFNEA
. . .    .|||||||||||||| .|...||||||||| |||||.| ||| |||||. | ||    .  .|| |.| |.|||. ||  |||  |||  .
elilkg.nsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgne..eerspifqqfldccfqllsqfpllfeftps

FLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSEAVLYPVCHVRNLMLWSAVYL
.|. . .  .|| .|||| |  |.| ... . .| |.|| ..   . | |  |  |    . |  . | | || |.|.
lllfisdnihsckygtflnncekdrvqdqvktktisiwsevnlnvnkflnpyynpqdiqsikpklysrclelwkacym
subfamily_MTMR6_pd Subfamily MTMR6 323-589 1.8e-93 305.9 In-house 126-392 (397) alignment 
Range on Protein: 323-589
Range on HMM: 126-392/397.0
QKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLC-TQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRP
. | ..|.|    |.||.|.| | |  . | |..  |.|. ||| .| | | |   . .. ..  ..||.|||..||.|.  .|...... .|| ...  
ellyvvdtrpklnalankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksvseflsglessgwlkhikavldasifiakavaeegas

VLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGenSDDLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHT
|||||||||||| |...||.||||||||||.||.||.| ||| ||||| .|||.   ..|  |  |.|.|.|.|| ||..|||..|||||.||..| .| 
vlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGll..dedskevsPiftqflecvwqlleqfpkafefnerfllelhdhv

YSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQSE-AVLYPVCHVRNLMLWSAVY
||| |||||.|. |.| ... .||| |.|. | . .. . | ||....| .|| |  .. .| ||.|.|
yscqfGtflgncekdrrdlklkertkslwayllerkddylnplykaetekevlkpdtapaalklwraly
subfamily_MTMR9_pd Subfamily MTMR9 323-591 4.4e-74 241.9 In-house 120-391 (393) alignment 
Range on Protein: 323-591
Range on HMM: 120-391/393.0
QKLLILDARSYAAAVANRAKGGGCECPEYYPNCEVVFMGMANIHSIRRSFQSLRLLCTQ-MPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRP
.| ||.| ||  || ..|.|||| |  . |.. . .   .....||  |.. |   |..   . ...|| ||...||...  ||. || |....|... |
kkGlivdtrsksaaenarskgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcldeegap

VLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQVLVEMEWLDFGHKFADRCGHGENSD-DLNERCPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQH
|.|| ..| | | |...||.|.|||..||..||. |.| ||.  || || |. .   ..   ... |||| .||||.|. .|||.|||||| .|. | .|
vvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfeh

TYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGN--KAFKNLLYSSqSEAVLYPVCHVRNLMLWSAVYLP
.||. ||||||.|..|| |.. ...| |.|| . . .  | | |.||.   . |. |  .   | ||| .||.
syssqfgtflcdneaerkelklkkktvslwsyvnrpeklkqflnplyea.naeviwpsvapqslelWselylr
0045098 (Phosphotyrosine protein) phosphatases II 343-444 4.6e-09 31.5 In-house 101-231 (278) alignment 
Range on Protein: 343-444
Range on HMM: 101-231/278.0
GGGCECPEYYPNCEVVFMGMANIHSIR---------------------RSFQS---LRLLCTQMPDPGNWLSA-----LESTKWLHHLSVLLKSALLVVH
.| . |..|.|. ...  |.  .. .                       ...|     | .. .|| |   .      || ......   || | ||. .
lgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

AVDQDQRPVLVHCSDGWDRTPQIVALAKLLL
 ..... ||||||| |..||  .||.  .| 
llldsggpvlVHCsaGvgRtGtlvaaylmle
0040439 (Phosphotyrosine protein) phosphatases II 344-442 5.4e-09 31.5 In-house 92-202 (249) alignment 
Range on Protein: 344-442
Range on HMM: 92-202/249.0
GGCECPEYYPNCEVVFMGMANIH--------------------SIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSAllvvhavdQDQRPVL
| . | .|.|. ... .|.  ..                        |.. | . .| .|| |   |  .  .... .   |...         .. |||
grekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel........pkggpvl

VHCSDGWDRTPQIVALAKL
||||.| .||. ..|.  .
VHCsaGvgRtGtfiaaylm
0050432 (Phosphotyrosine protein) phosphatases II 344-442 5.1e-06 21.5 In-house 146-255 (308) alignment 
Range on Protein: 344-442
Range on HMM: 146-255/308.0
GGCECPEYYPNC---EVVFMGMANI---------HSIRRSF-----------QSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLksallvvhavdqDQR
|   |..|.|.    ...  |.  .         . ..| .           .   . .|  || |   |. .  ..|...   |            .. 
grekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl............pgg

PVLVHCSDGWDRTPQIVALAKL
|..||||.|  ||  ..||  |
pivVHCsaGvGRtGtfialdll
0039614 (Phosphotyrosine protein) phosphatases II 345-442 2.3e-08 29.3 In-house 11-245 (297) alignment 
Range on Protein: 345-442
Range on HMM: 11-245/297.0
GCECPEYYPNCEVVFMGMANIHSIRRSFQSL------------------------------------------------------------RLLCTQMPD
 . .|  . .. . .. . ... ... |..|                                                            . ..|| | 
sipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPl

PGN----------------------------------------------WLSALE------------------------STKWLHHLSV-LLKSALLVVH
|..                                              .|.  .                         |.| .|    .|.. | ...
petvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslelllefle

AVDQ------DQRPVLVHCSDGWDRTPQIVALAKL
.|..      ...|||||||.| .||  ..|.  .
lvrealaelpkggpvlVHCsaGvgRtGtfiaaylm
0049772 (Phosphotyrosine protein) phosphatases II 346-443 5.4e-08 28.4 In-house 149-236 (314) alignment 
Range on Protein: 346-443
Range on HMM: 149-236/314.0
CECPEYYpnCEVVFMGMANIHSIR---RSFQS--LRLLCTQMPDpGNWL-SALestkwlhhlsvlLKSALLVVHAVdQDQRPVLVHCSDGWDRTPQIVAL
.......  .| ... .......      |.   ...|.. .|| |..  ..             ....| ..... ....||||||..|..||.  |..
lildgng..neptaadlellkeelydpelferlgikylripvpD.gsaplled............fdeflefieea.dkggpvlvHCkaGkgRtgtfvva

AKLL
| |.
aylm
0051429 (Phosphotyrosine protein) phosphatases II 347-507 1e-09 34.0 In-house 62-208 (272) alignment 
Range on Protein: 347-507
Range on HMM: 62-208/272.0
ECPEYYPNCEVVFMGMANIHSIRRS---------------------------------FQSLRLLCTQMPDPGNWLSAleSTKWLHHLsvlLKsallvvh
 |. | |....... . . .  . .                                 .. . |..|..|| | . .|    ..|..|   |.       
kcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellell...ld.......

avdqdQRPVLVHCSDGWDRTPQIVALAKLLLDpyyrtiegfqvlvemewldfghkfadrcghgensddlnercpvfLQ--------------WLDCVHQL
     ..||||||| |.|||  .|||  |||.                                            .               ....|..|
.....ggpvlvHCsaGkdRTGtvvallllllg............................................vsletivddYlltnlyleeaveel

QRQFPCSF
..|.|...
raqrpgav
0047943 (Phosphotyrosine protein) phosphatases II 347-442 2.5e-06 22.6 In-house 118-228 (273) alignment 
Range on Protein: 347-442
Range on HMM: 118-228/273.0
ECPEYYPNCE---VVFMGMANIHS--------------------IRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKsallvvhaVDQDQRPVL
 |. |.|. .   ..  |   ..                        |..   ...|  || |   |  .  ......   |.         . .. ||.
kcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale........alpsngpvv

VHCSDGWDRTPQIVALAKL
||||.|  ||  ..||  |
VHCsaGvgRtgtfialdll
0036941 (Phosphotyrosine protein) phosphatases II 347-442 2.7e-06 22.4 In-house 119-230 (297) alignment 
Range on Protein: 347-442
Range on HMM: 119-230/297.0
ECPEYYPNC--EVVFMGMANIHSIRRSF--------QSLRLLCTQMPdPGNWLSALESTKWLHHlSVL--LKSALLVVHAVDQ------DQRPVLVHCSD
 |..|.|.   |..  |   .. .. .           |....|. . .   .  .  |.| .| .|    .| |  ...|..      .. |||||||.
kcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgng.esrtvthfhytgwpdh.gvpespaslldfielvrkvlkllpsggpvlVHCsa

GWDRTPQIVALAKL
|  |.  ..|.  .
GvgRsgtfiaadlm
0051082 (Phosphotyrosine protein) phosphatases II 348-445 2.1e-08 29.5 In-house 49-118 (151) alignment 
Range on Protein: 348-445
Range on HMM: 49-118/151.0
CPEYYPNCEvvfmgmanihsirrsFQSLRLLCTQMPDPGnwlsalestkwlhhLSVLLKSALLVVHAVDQD-QRPVLVHCSDGWDRTPQIVALAKLLLD
||||.|. .               .. |.. .. .||||              |.......| ........ . ||||||| |..||  .|||  .||.
cpeylpelg...............ievlhipildwpdpg..............lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg
subfamily_pats1_pd Subfamily pats1 354-484 2.3e-23 74.5 In-house 335-467 (691) alignment 
Range on Protein: 354-484
Range on HMM: 335-467/691.0
NCEVVFMGMANIHSIRRSFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQI---VALAKLLLDPYYRT
 ....|. .   . ..  |  |    ... .. .  . .|  ||.  . .||..|. |   .|. .  .|   .|. . . ..    .||..|.||.|||
ssniiflslPtrekveerffdllqsilsldgsddewkeieeskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsdPfyrt

IEGFQVLVEMEWLDFGHKFADRCGHGEnSDDLNE
..||.||.| |||..|. |.... | | |||||.
ldGfkvliekewlsyGfPfskinyhke.sddlnn
subfamily_MTMR10_pd Subfamily MTMR10 362-546 1.7e-50 163.9 In-house 123-311 (380) alignment 
Range on Protein: 362-546
Range on HMM: 123-311/380.0
MANIHSIRRSFQSLRLLCTQMPDP------GNWLSALESTKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTIEGFQ
...|. . .... || ||.            .|||.||.|.||.  ...|. |  .|..| ...|.|..  |.| |    .  || |.|||.||||.|||
lpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfq

VLVEMEWLDFGHKFADRCGHGENSDDLNErcPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERT
 |.. ||   ||.| ||.||. .|.. ..  ||||  ||||.|| .||| .|||.| ||..|. ...|..|.|||.|....| .. ..   
sliqkewvaaghpfldrlghikpsekses..pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlkavvsssp
0046845 (Phosphotyrosine protein) phosphatases II 371-443 7e-06 21.1 In-house 164-228 (284) alignment 
Range on Protein: 371-443
Range on HMM: 164-228/284.0
SFQSLRLLCTQMPDPGNWLSALESTKWLHHLSVLLKSallvvhavDQDQRPVLVHCSDGWDRTPQIVALAKLL
|..   . .|. || |   |.    ..|. .  ||..          .. |..||||.|  ||  ..||  ||
srtvthfhytswpdhgvppspedlleflrlvrellen........lpgggpivVHCsaGvgRtGtfialdlll
0044763 (Phosphotyrosine protein) phosphatases II 372-439 8.4e-08 27.6 In-house 76-130 (178) alignment 
Range on Protein: 372-439
Range on HMM: 76-130/178.0
FQSLRLLCTQMPDPGNWLSALESTKWLHHLSvllksallvvhavDQDQRPVLVHCSDGWDRTPQIVAL
.| |.. .  ...|      || .......              |....||||||| |..|.. .||.
iqylhipipDhgvpdllehflefvefieeal.............dekggpvlVHCsaGvgRsgtlvaa
0043336 (Phosphotyrosine protein) phosphatases II 376-442 1.9e-07 26.3 In-house 89-233 (278) alignment 
Range on Protein: 376-442
Range on HMM: 89-233/278.0
RLLCTQMPDPGNW-------------------------------------------------------------------------LSALESTK-----W
. ..|| | |...                                                                            .  ..     .
kfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgv

LHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKL
 ..|| ||.    | .|.. .. |||||||.| .||  ..||  |
peslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyll
0041856 (Phosphotyrosine protein) phosphatases II 395-440 2.7e-06 22.6 In-house 85-130 (182) alignment 
Range on Protein: 395-440
Range on HMM: 85-130/182.0
TKWLHHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALA
. |  |    | ..|  ...| ....||||||| | .||. .||. 
lpwpDhgvpdldelldfieevleeggpvlVHCsaGvgRtgtlvaay
0051299 (Phosphotyrosine protein) phosphatases II 395-442 3.2e-06 22.3 In-house 190-242 (288) alignment 
Range on Protein: 395-442
Range on HMM: 190-242/288.0
TKWL-----HHLSVLLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKL
|.|      .... ||.   || .|  ... ||.||||.| .||  ..||  |
tnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdll
0040438 (Phosphotyrosine protein) phosphatases II 396-442 8.5e-06 20.7 In-house 181-232 (317) alignment 
Range on Protein: 396-442
Range on HMM: 181-232/317.0
KWLHH-LSVLLKSALLVVHAVDQ----DQRPVLVHCSDGWDRTPQIVALAKL
 | .| .   ... |  ..||..    .. |||||||.| .||  ..|.  .
gWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylm
0045450 (Phosphotyrosine protein) phosphatases II 398-443 8.5e-07 24.5 In-house 207-258 (307) alignment 
Range on Protein: 398-443
Range on HMM: 207-258/307.0
LHHLSVLLKSALLVVHAVDQ------DQRPVLVHCSDGWDRTPQIVALAKLL
 |...  ....|  ...|..      .. |||||||.| .||. ..|.  .|
dhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylml
0042113 (Phosphotyrosine protein) phosphatases II 400-442 2.6e-06 22.5 In-house 151-199 (245) alignment 
Range on Protein: 400-442
Range on HMM: 151-199/245.0
HLSVL-LKSALLVVHAVDQ-----DQRPVLVHCSDGWDRTPQIVALAKL
|     |.. | ....|..     .. |||||||.| .||  ..|.  .
hgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm
0037934 (Phosphotyrosine protein) phosphatases II 400-444 6.8e-06 21.3 In-house 154-203 (243) alignment 
Range on Protein: 400-444
Range on HMM: 154-203/243.0
HLSVLLKSALLVVHA-----VDQDQRPVLVHCSDGWDRTPQIVALAKLLL
.|  .|. .  ....     .. ...||||||| | .||  ..|.  .||
dlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmll
0049260 (Phosphotyrosine protein) phosphatases II 402-443 1.8e-06 23.3 In-house 71-113 (152) alignment 
Range on Protein: 402-443
Range on HMM: 71-113/152.0
SVLLKSALLVVHA-VDQDQRPVLVHCSDGWDRTPQIVALAKLL
| ||. .||...    ... ||||||| | .||. .||.  .|
sqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml
0043147 (Phosphotyrosine protein) phosphatases II 403-443 1.6e-06 23.5 In-house 79-124 (172) alignment 
Range on Protein: 403-443
Range on HMM: 79-124/172.0
VLLKSALLVVHAVDQ-----DQRPVLVHCSDGWDRTPQIVALAKLL
 ||.  | ... .|.     .. ||||||| |..||. .||.  .|
pllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml
0048179 (Phosphotyrosine protein) phosphatases II 404-442 1.7e-06 23.3 In-house 68-106 (144) alignment 
Range on Protein: 404-442
Range on HMM: 68-106/144.0
LLKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKL
|| ..|  .... .. .||||||| | .||. .||.  .
llleflefieealeeggpvlVHCsaGvgRtgtlvaaylm
0048076 (Phosphotyrosine protein) phosphatases II 405-441 1.5e-06 23.5 In-house 67-103 (145) alignment 
Range on Protein: 405-441
Range on HMM: 67-103/145.0
LKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAK
| ..|  .... .. .||||||| | .||. .||.  
lleflefieealkeggpvlVHCsaGvgRtgtlvaayl
0046846 (Phosphotyrosine protein) phosphatases II 405-444 6.6e-06 21.5 In-house 95-134 (176) alignment 
Range on Protein: 405-444
Range on HMM: 95-134/176.0
LKSALLVVHAVDQDQRPVLVHCSDGWDRTPQIVALAKLLL
| ..|  .. . .. .||||||| |  ||. .||.  | |
llellefirealkeggpvlVHCsaGigRtgtlvaayllel
0036282 (Phosphotyrosine protein) phosphatases II 406-447 3.3e-06 22.4 In-house 89-132 (174) alignment 
Range on Protein: 406-447
Range on HMM: 89-132/174.0
KSALLVVHAVDQ--DQRPVLVHCSDGWDRTPQIVALAKLLLDPY
 ...  |. . .  ...||||||| | .||. .||.  .|   .
lefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll
PTPc_DSPc_SM00012 407-516 2.7e-11 39.0 In-house 21-99 (105) alignment 
Range on Protein: 407-516
Range on HMM: 21-99/105.0
SALLVVHAVDQ---D---QRPVLVHCSDGWDRTPQIVALAKLLLDPYYRTiegfqvlvemewldfghkfadrcghgensddlnercpVFLQWLDCVHQLQ
| | ...||..   .   . ||.||||.|..|| ..|||. || . ...|                                      .......|..| 
silellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket.....................................kevdifqivkelr

RQFPCSFEFNEAFLVK
.| | .....| .|. 
kqRpgmvqteeqylfl
subfamily_MTMR14_pd Subfamily MTMR14 410-478 6.8e-10 30.3 In-house 258-333 (357) alignment 
Range on Protein: 410-478
Range on HMM: 258-333/357.0
LVVHAVDQDQ-RPVLVHCSDGWDRTPQIVALAKLLLDP---YYRTIEGFQV---LVEMEWLDFGHKFADRCGHGEN
|... | .|.   .||||  ||||||  |.| .| |      .....  ..    |  .|. |||...||  .||.
lllkyvkededsGllvhcisGWdrtPlfvsllrlslWadglihqslsaaellyltvaydWflfghqlpdrlkkgee
subfamily_pats1_pd Subfamily pats1 486-569 5e-26 83.3 In-house 553-636 (691) alignment 
Range on Protein: 486-569
Range on HMM: 553-636/691.0
CPVFLQWLDCVHQLQRQFPCSFEFNEAFLVKLVQHTYSCLFGTFLCNNAKERGEKHTQERTCSVWSLLRAGNKAFKNLLYSSQS
 |.|.|.|| | |||..||  ||||| .|. ||....|  ||.||...||.. |..  .|. |.||. .  .  | ||||   .
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinqnksrfinllykhsa
Cytochrom_B562 Cytochrome b562 982-1067 5.3e-06 13.3 Pfam-A 13-96 (103) alignment 
Range on Protein: 982-1067
Range on HMM: 13-96/103.0
SLSRQLSAMSCSSAHLHSRNLHHKWLHSHSGRPSATSSpDQPSRSHLdDDGMSVYTDTIQQRLRQIESGHQQEVETLKKQVQELKS
.... ..|..  . . .  .|.   ...  ..|.  .. |..   .  . |.   .|.|..  .....|  .|. .  |....|..
nykqaakaddaeelkealnklrsaaedakkkkppklee.dseemkdY.qeGldklideidkaealakagkleeAkqalkelkdlrk
FYVE FYVE zinc finger 1128-1201 1.8e-16 49.8 Pfam-A 2-68 (69) alignment 
Range on Protein: 1128-1201
Range on HMM: 2-68/69.0
RWLPDHLAAHCYACDSAFWLASRKHHCRdtdrvdqtwNCGNVFCSSCCNQKVPVP--SQQLFEPSRVCKSCYSSLH
.| .|. | .|  |...| | .|.||||         .||.|.||.|....|...  ...  .. ||||.|...|.
kwvddaeakkCeiCakkFsltrrrhhCr.........lCGkvvCskCsskrvekleeesaeekevrvCkeCleels