Gene MTMR4 in Homo sapiens

Synonym: FYVE-DSP2, ZFYVE11, MTMR4

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR3
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP054_AA protein Get Run
HsapP054_AA_166-591 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Myotub-related Myotubularin-like phosphatase domain 140-534 2.2e-148 486.7 Pfam-A 1-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 140-534 2.2e-148 486.7 In-house 1-352 (353) alignment
subfamily_MTMR3_pd Subfamily MTMR3 145-586 2.1e-233 767.9 In-house 1-441 (442) alignment 
Range on Protein: 145-586
Range on HMM: 1-441/442.0
AYHAWCLGLTEEDQHTHLCQPGEHIRCRQEAELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAI
|||||.|  .|......|.............|..|.||||...||.|..||..|||.|||.||.||..|||..|..||||||.||.|.||.|| .|||..
ayhawkleeeekerdgfllraasvaeeklkeeverlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavl

ARCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRATGGSLSTGNN---DTSEACDADFDssltaCSGVESTA-APQKLLILDARSYTAAVANRAKGGG
|||||||..|.|||||.||.|...|||||||| |..|.|..||.|..   |.|.|.||..|     .|. ||.| ...||||.||||||||.||||||||
arcsqPevgwlgWrnaedekllkaiakacaldagekakgeklsngkakkkdvsdaldaead.....aseeeslaeekkkllivdarsytaafanrakgGG

CECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLD
||.|||||||||||.|.|||||.|.||..|||..||.||.||||||||.|||||.|||.||||| |...||.||||||||||||||||.|||||||.|||
celeeyypncevvflglanihavrksfnslrallsqspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllld

PYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKR
|||||||||.||||..|||||||| |||||.|||.|.||.|||||||||.|||| .|||..|||||||||||||||||||.||||||. .|||......|
pyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeekvker

TCSVWALLRAGNKNFHNFLYTPSSDMVLHPVCHVRALHLWTAVYLP
|.|||.|||| .|...|.||......||.|...||.|.||..|||.
tlsvWsllrakekeyrnllykekteavllpavsvrelklwsevyle
0040695 (Phosphotyrosine protein) phosphatases II 171-587 1.2e-147 485.5 In-house 11-385 (388) alignment 
Range on Protein: 171-587
Range on HMM: 11-385/388.0
CRQEAELARMGFDLQnVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIA
   . || |.|..|. .||.|..|.||.||||||..|.||..|.|..|..||.|||..||||..||| .|||.. |.||| ......|. .|| |...| 
ydilrelkrlglgld.lwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledeklleail

KACAldpgtratggslstgnndtseacdadfdssltacsgvestaAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYL
|..                                           ..||||.|.|... |.||||.|||.|.|..|||.|..|... ||| .|.|.| |
kllp.........................................nlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqkl

RAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGH
. .| ..|| .|.||.||...||......|..|||... .|... .||||||||||||.|...|| .|||||||||||||||.| .|| ||||| ||.||
ldaclnvpdslnllslleesgwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlgh

QENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPSSDMVLHP
 |.. |..| .||||..|| |.|||.|||. ||||| .|. |..|.|||..|||| |...|| . ....||.|.| .|   .. |.|.|| |||..||.|
leseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkseflnplYdpsslevllp

VCHVRALHLWTAVYLPA
...|. |.||. .||. 
slsvldlllWleyylrw
subfamily_MTMR6_pd Subfamily MTMR6 172-273 3.2e-21 68.1 In-house 23-122 (397) alignment 
Range on Protein: 172-273
Range on HMM: 23-122/397.0
RQEAELARMGFDlQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPeISWWGWRNADDEYLVTSIAK
  .||..|||   .. | ....| .|.|| .||..| ||  .| . |   . ||| .|.||. | | .| ||| ||||| .|    |  .|| |.  | |
dlkaeytrmgvp.nekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqp.lsgfsarcledeklleairk

AC
| 
an
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 173-584 1.1e-125 412.0 In-house 21-399 (404) alignment 
Range on Protein: 173-584
Range on HMM: 21-399/404.0
QEAELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKA
.| | .|.|.  .  ||.|.|||.|.||..||. | ||  |.|.||..|||||| .||||...||  ... |.|.||| .   . |  .||.|. || ||
aeeEykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplvGltksrseedEklinsirka

CALDPgtratggslstgnndtseacdadfdssltacsgvestaapqKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRA
..  .                                         .|.|||||... ||||.||| |.|  . | |||. |....||| .|.|.. |. 
ktqle.........................................tlyildarpkanavansakgagyedisryenceieflnienihelreslkklkk

VCSQMPDP-SNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHq
..... .  .|||| |||..||.|.. .|...  ...... |. .||||||||||||.|...|...||||||||.|||.||.| .||.||||| .|.|. 
avnsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigq.

ENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPSSDM---VL
.. ....|. |.|||..| |.||.||||  ||||| ||.|.... ||| .|||| ..  ||...|..| | |.|||| | .... | ||  ..       
ttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWalleankseylnplyilekkeqkeni

HPVC-----HVRALHLWTAVY
.  .     ... ..||   |
tssessssadikliklWseyy
subfamily_MTMR1_pd Subfamily MTMR1 173-273 3.1e-26 84.6 In-house 12-112 (389) alignment 
Range on Protein: 173-273
Range on HMM: 12-112/389.0
QEAELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKA
 |||| |.|   ...||....|..|.||..||..| ||  ..|..|..||.||| .|.||... . .|.|.|.|.|||     | |...|| ... | .|
peaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskedekylqailea

C
 
n
subfamily_MTMR9_pd Subfamily MTMR9 173-273 9.3e-24 76.2 In-house 20-119 (393) alignment 
Range on Protein: 173-273
Range on HMM: 20-119/393.0
QEAELARMGFDlQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKA
.| |.|..    .. ||.|..| |.|.|.|||....||  |.|.||. .|.||.  |.||  |.| ...|.. |.||| ..  | |  .|| |. .. |.
renefaklisa.sdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgssgkrckedekllnlvlkk

C
 
l
subfamily_pats1_pd Subfamily pats1 176-246 1.5e-06 18.9 In-house 14-82 (691) alignment 
Range on Protein: 176-246
Range on HMM: 14-82/691.0
ELARMGFDLQNVWRVSHINSNyKLCPSYPQKLLVPVWITDKELENVASFRSWKrIPVVVYRHLRNGAAIAR
|  |.. ||   ||| .. |. .|.  ||.. |||  ..|. |   .  || | |||. . .  | ... |
egqrlkldldkdwrvveflsr.dlseiyPkrilvPklvsdellvsyvrkrssk.iPvlswsnqnnksslfr
subfamily_MTMR5_pd Subfamily MTMR5 177-251 3.8e-17 54.3 In-house 14-94 (483) alignment 
Range on Protein: 177-251
Range on HMM: 14-94/483.0
LARMGFDLQ------NVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPE
  |.|...       . .|.|..|..|..| |||  ..||. . |.... ||     .|.|||..|| ||.| . | ...|
ykRlGlgalngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfe
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 186-272 7.8e-18 56.4 In-house 40-126 (405) alignment 
Range on Protein: 186-272
Range on HMM: 40-126/405.0
NVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKA
  |.|. || .||.| ||.  |.|    .||.||.. ||||  ||| . ..     |.|.||||| .     |  .||. ..|.| .
cywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqplvgierarcpedelycsslals
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 308-585 2.3e-72 236.0 In-house 120-402 (405) alignment 
Range on Protein: 308-585
Range on HMM: 120-402/405.0
CSGVESTAAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLR-AVCSQMPDP-------SNWLSALESTKWLQHLSVM
|| .  .|  . | ..|||    |.|| |.| | |    |||| .||| . ||| ||.|.. |  |. |   |          .   .| | |. |.  .
csslalsapsktlylidarpklnaiantangagfenihnypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksi

LKAAVLVANTVDrEGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEdqNEQCPVFLQWLDSVHQLLKQFP
|.|| . |. .   |  .|||||||||||||| .|..|||||||||. |||||.| .|| |||||  | ||    |  .|. |.| |.|| . |||.|||
leaatfsaelil.kgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgne..eerspifqqfldccfqllsqfp

CLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPSSDMVLHPVCHVRALHLWTAVYL
 ||||  ..|. . .  .|| ||||| |   .| . ..  .| |.|. ..   ..| |  | |     ..|  . |.| || |.|.
llfeftpslllfisdnihsckygtflnncekdrvqdqvktktisiwsevnlnvnkflnpyynpqdiqsikpklysrclelwkacym
subfamily_MTMR1_pd Subfamily MTMR1 312-585 1.3e-107 352.4 In-house 110-384 (389) alignment 
Range on Protein: 312-585
Range on HMM: 110-384/389.0
ESTAAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVD
|. |  .||||||||| ..||||.|||.| | ||.| |.|..|. ..|||..|.|.. |....    | ..|||||||||||.|....|..|| ....|.
eanaqsekllildarssvnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvlpnvddkkwlsalestkWlehiklilagavkivekve

REGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVK
.|   |||||||||||| |...||..|||.||||.|||.||.| .|| ||||| .| || .. . ..|. |||||..|.|.|| .|||. ||||| ||. 
tektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFefneefLit

LVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPS-SDMVLHPVCHVRALHLWTAVYL
|..| ||||.|||| |.  ||.|......| |.|. . . ...| | ||... .. || |.. .| |.||.  ||
lldhlysclfGtflfnsekervkekvkektvslwsyvnsskeeftnplyaeelekkvlypkaslrrlelWkeyyl
subfamily_MTMR6_pd Subfamily MTMR6 315-584 3.4e-94 308.3 In-house 123-392 (397) alignment 
Range on Protein: 315-584
Range on HMM: 123-392/397.0
AAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVC-SQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDRE
.  . | ..|.|    |.||.|.| | | |. | |..  |.|. ||| .|.| | |  |.  . .. |..||.|||..||.|.  .|.|....|..| .|
pnsellyvvdtrpklnalankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksvseflsglessgwlkhikavldasifiakavaee

GRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQEnvEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLV
|  |||||||||||| |...||..||||||||..||.||.| .|| ||||| .|||. .  ||. |  |.|.|.|..| |||.|||. |||||.||..| 
gasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGlld..edskevsPiftqflecvwqlleqfpkafefnerfllelh

QHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPSSD-MVLHPVCHVRALHLWTAVY
.| ||| .||||.|.  .|.. .. .|| |.|| | . .... | ||.....  ||.|  .. ||.||.|.|
dhvyscqfGtflgncekdrrdlklkertkslwayllerkddylnplykaetekevlkpdtapaalklwraly
subfamily_MTMR9_pd Subfamily MTMR9 318-586 1.2e-72 237.2 In-house 120-391 (393) alignment 
Range on Protein: 318-586
Range on HMM: 120-391/393.0
QKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVC-SQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRP
.| ||.| || .|| ..|.|||| | |. |.. . .   ..... | .|.. |  .|  .  . ...|| ||...||...  .|.||. ||...|.|| |
kkGlivdtrsksaaenarskgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcldeegap

VLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVE-DQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQH
|.|| ..| | | |...||...|||..||..||. |.| .|.  || |  |. .    |  .... |||| .||.|.|.|.|||. ||||| .|. | .|
vvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfeh

TYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGN--KNFHNFLYTPsSDMVLHPVCHVRALHLWTAVYLP
.||. .||||..|  ||.. .. |.| |.|. . . .  |.| | || .  . |. |  .  .|.||. .||.
syssqfgtflcdneaerkelklkkktvslwsyvnrpeklkqflnplyea.naeviwpsvapqslelWselylr
0040439 (Phosphotyrosine protein) phosphatases II 339-437 5.1e-09 31.6 In-house 92-202 (249) alignment 
Range on Protein: 339-437
Range on HMM: 92-202/249.0
GGCECEEYYPNCEVVFMGMANIH--------------------AIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAvlvantvdREGRPVL
| . |..|.|. ... .|.  ..                       .|...|   .  .|| .   |  .  .... .  .|...        ..| |||
grekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel........pkggpvl

VHCSDGWDRTPQIVALAKI
||||.| .||. ..|.  .
VHCsaGvgRtGtfiaaylm
0045098 (Phosphotyrosine protein) phosphatases II 339-438 2.6e-08 29.1 In-house 102-230 (278) alignment 
Range on Protein: 339-438
Range on HMM: 102-230/278.0
GGCECEEYYPNCEVVFMGMANIHAI-----------------------------RNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANT
| . |..|.|. ...  |.  .. .                              . ..||       |. . . | || ......    |   .|. ..
grekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

VDREGRPVLVHCSDGWDRTPQIVALAKIL
.. .| ||||||| |..||  .||.  .|
lldsggpvlVHCsaGvgRtGtlvaaylml
0051429 (Phosphotyrosine protein) phosphatases II 342-440 1.8e-09 33.2 In-house 62-176 (272) alignment 
Range on Protein: 342-440
Range on HMM: 62-176/272.0
ECEEYYPNCEVVFMGMANIHAIRNSFQYLR------------------AVCSQMPDPSNWLSALESTKWLQHL---SVMLKAAVLVANtvdreGRPVLVH
 |. | |....... . . .| . .. .||                  ..    .. . ..  |  | |. |    . .|..  |...     |.|||||
kcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.....ggpvlvH

CSDGWDRTPQIVALAKILLD
|| |.|||  .|||  .||.
CsaGkdRTGtvvallllllg
0041856 (Phosphotyrosine protein) phosphatases II 343-435 1.2e-06 23.8 In-house 67-130 (182) alignment 
Range on Protein: 343-435
Range on HMM: 67-130/182.0
CEEYYPNCEvvfmgmanihaIRNSFQYLRAVCSQMPDPSnWLSALESTKWLQHlsvmlkaavlvantvdrEGRPVLVHCSDGWDRTPQIVALA
.| |.|. .            |. .|||.  .  .. |. . ..|.  .. ..                 ||.||||||| | .||. .||. 
eelywpell...........erlgiqylylpwpDhgvpd.ldelldfieevle.................eggpvlVHCsaGvgRtgtlvaay
subfamily_MTMR5_pd Subfamily MTMR5 345-581 1.2e-62 204.3 In-house 223-476 (483) alignment 
Range on Protein: 345-581
Range on HMM: 223-476/483.0
EYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQM---PDPSN--WLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILL
| . ..|.. . . .| ....||. |. .|.      ....  .|...|   ||| .| .|. .. |.. .| .|  |||   |||| | |...||..||
evdskaefipvelveirqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqlll

DPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQnEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNI--
||||||||||.|||| .|| |||.| .|. .... .      |||||.|| |||. .|||  ||||. .|  |  |  |. . ||| .   || . ..  
dpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqss.gfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesglly

--------YKRTCSVWALLRAGNKN---FHNFLYTPSSDMVLHPVCHVRALHLWT
         | . |||  . . .|.   |.||||.|....||.| ..| .|..|.
eekaekrakkagksvwdyidrqhkrspifynflyspdesevlrPssnvsslkvWd
0049772 (Phosphotyrosine protein) phosphatases II 347-435 1.4e-07 27.0 In-house 155-233 (314) alignment 
Range on Protein: 347-435
Range on HMM: 155-233/314.0
YpnCEVVFMGMANIHairnsfqylrAVCSQMPDPSNWLSALESTKWLQH---LSVMLKAAVLVANTVdREGRPVLVHCSDGWDRTPQIVALA
.  .| ... .....           ..   ......   .  . .  .   |. ...... . ... ..|.||||||..|..||.  |..|
g..neptaadlellk..........eelydpelferlgikylripvpDgsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaa
subfamily_pats1_pd Subfamily pats1 349-478 1.9e-25 81.4 In-house 335-467 (691) alignment 
Range on Protein: 349-478
Range on HMM: 335-467/691.0
NCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDrEGRPVLVH-CSDGWDRTPQI---VALAKILLDPYYR
 ....|. .   . ... |  |     .. .. .  . .|  ||.  . ..|.||| |.| .| ||. ||..  .|. . . ..    .||..|.||.||
ssniiflslPtrekveerffdllqsilsldgsddewkeieeskwvdsvkllleaavkvsnlld.eGssvllknsidsPlieldlasisslaqvlsdPfyr

TLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQN
||.||.||.| .||..|. | ... |.|. . .|
tldGfkvliekewlsyGfPfskinyhkesddlnn
0044763 (Phosphotyrosine protein) phosphatases II 351-435 5e-09 31.6 In-house 60-131 (178) alignment 
Range on Protein: 351-435
Range on HMM: 60-131/178.0
EVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSvmlkaavlvantvDREGRPVLVHCSDGWDRTPQIVALA
|  |...   .  ....|||.  .. ...|.     || .......              |..|.||||||| |..|.. .||. 
elgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeal.............dekggpvlVHCsaGvgRsgtlvaay
subfamily_MTMR10_pd Subfamily MTMR10 357-535 2e-46 150.5 In-house 123-305 (380) alignment 
Range on Protein: 357-535
Range on HMM: 123-305/380.0
MANIHAIRNSFQYLRAVCSQMPD------PSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQ
...|. . .... ||..|             .|||.||.|.||.  ...|. |. ...|| ...|.|..  |.| |    .  || ..|||.|||..|||
lpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfq

VLVESDWLDFGHKFGDRCGHQENVEDQNEqcPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKR
 |..  |   ||.| ||.||  . |....  ||||  || |.|||.|||  |||.| ||..|. ...|....|||.|.. .|.| 
sliqkewvaaghpfldrlghikpsekses..pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlka
0051082 (Phosphotyrosine protein) phosphatases II 359-439 7.6e-08 27.6 In-house 57-117 (151) alignment 
Range on Protein: 359-439
Range on HMM: 57-117/151.0
NihairnsFQYLRAVCSQMPDPSnwlsalestkwlqhLSVMLKAAVLVANTVDRE-GRPVLVHCSDGWDRTPQIVALAKILL
.       ...|.  .  .|||.              |.....|.. . . ...  . ||||||| |..||  .|||  .||
g.......ievlhipildwpdpg..............lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmll
0048179 (Phosphotyrosine protein) phosphatases II 366-437 6.7e-07 24.7 In-house 49-106 (144) alignment 
Range on Protein: 366-437
Range on HMM: 49-106/144.0
SFQYLRAVCSQMPDPSNWLSALESTKWLQHLsvmlkaavlvantvDREGRPVLVHCSDGWDRTPQIVALAKI
 .|||.  .  .. |. .   ||  ......               .||.||||||| | .||. .||.  .
giqylhlpwpDhgvpdllellleflefieea..............leeggpvlVHCsaGvgRtgtlvaaylm
0039614 (Phosphotyrosine protein) phosphatases II 371-437 4.2e-07 25.2 In-house 102-245 (297) alignment 
Range on Protein: 371-437
Range on HMM: 102-245/297.0
RAVCSQMPDPSN----------------------------------------------WLSALE------------------------STKWLQ-----H
. ...| | |..                                              .|.  .                         |.|       .
kfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvpps

LSVMLKAAVLVANTVDR--EGRPVLVHCSDGWDRTPQIVALAKI
|...|..  || . . .  .|.|||||||.| .||  ..|.  .
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylm
0040438 (Phosphotyrosine protein) phosphatases II 391-437 4.7e-06 21.6 In-house 181-232 (317) alignment 
Range on Protein: 391-437
Range on HMM: 181-232/317.0
KW-----LQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKI
 |      .... .|.   .| .  ...| |||||||.| .||  ..|.  .
gWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylm
0051299 (Phosphotyrosine protein) phosphatases II 391-437 8.9e-06 20.8 In-house 191-242 (288) alignment 
Range on Protein: 391-437
Range on HMM: 191-242/288.0
KW-----LQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKI
.|      .... .|.   || .     | ||.||||.| .||  ..||  .
nwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdll
0043336 (Phosphotyrosine protein) phosphatases II 394-437 4.3e-07 25.2 In-house 190-233 (278) alignment 
Range on Protein: 394-437
Range on HMM: 190-233/278.0
QHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKI
 .|| .|.    | . .. .. |||||||.| .||  ..||  .
eslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyll
0045450 (Phosphotyrosine protein) phosphatases II 394-438 3.6e-06 22.4 In-house 212-258 (307) alignment 
Range on Protein: 394-438
Range on HMM: 212-258/307.0
QHLSVMLKAAVLVANTVD--REGRPVLVHCSDGWDRTPQIVALAKIL
.... .|.   .| . ..  ..| |||||||.| .||. ..|.  .|
psfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylml
0049260 (Phosphotyrosine protein) phosphatases II 398-438 9.8e-07 24.1 In-house 72-113 (152) alignment 
Range on Protein: 398-438
Range on HMM: 72-113/152.0
VMLKAAVLVANT-VDREGRPVLVHCSDGWDRTPQIVALAKIL
 .|. ..|. .    ..| ||||||| | .||. .||.  .|
qlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml
0048076 (Phosphotyrosine protein) phosphatases II 400-437 9.1e-07 24.2 In-house 67-104 (145) alignment 
Range on Protein: 400-437
Range on HMM: 67-104/145.0
LKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKI
| ...   ... .||.||||||| | .||. .||.  .
lleflefieealkeggpvlVHCsaGvgRtgtlvaaylm
0036282 (Phosphotyrosine protein) phosphatases II 400-441 3.8e-06 22.2 In-house 89-131 (174) alignment 
Range on Protein: 400-441
Range on HMM: 89-131/174.0
LKAAVLVANTVDR-EGRPVLVHCSDGWDRTPQIVALAKILLDP
|..  .| . . . .|.||||||| | .||. .||.  .|   
lefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgl
0046846 (Phosphotyrosine protein) phosphatases II 401-439 4.7e-06 22.0 In-house 96-134 (176) alignment 
Range on Protein: 401-439
Range on HMM: 96-134/176.0
KAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILL
  ..   ... .||.||||||| |  ||. .||.  . |
lellefirealkeggpvlVHCsaGigRtgtlvaayllel
0042113 (Phosphotyrosine protein) phosphatases II 404-437 5.5e-06 21.5 In-house 164-199 (245) alignment 
Range on Protein: 404-437
Range on HMM: 164-199/245.0
VLVANTVD--REGRPVLVHCSDGWDRTPQIVALAKI
.  ....    .. |||||||.| .||  ..|.  .
lefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm
PTPc_DSPc_SM00012 405-511 1e-09 33.9 In-house 38-99 (105) alignment 
Range on Protein: 405-511
Range on HMM: 38-99/105.0
LvantvdreGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTlegfqvlvesdwldfghkfgdrcghqenvedqneqcpVFLQWLDSVHQLLKQFPCLFEF
         . ||.||||.|..|| ..|||. .| . ...|                                      ...... |..| || | ....
s........skpvvVhCsaGvgRtgtfvaldillqqleket.....................................kevdifqivkelrkqRpgmvqt

NEAFLVK
.| .|. 
eeqylfl
0043147 (Phosphotyrosine protein) phosphatases II 406-438 1.2e-06 23.9 In-house 87-124 (172) alignment 
Range on Protein: 406-438
Range on HMM: 87-124/172.0
VANT-----VDREGRPVLVHCSDGWDRTPQIVALAKIL
. .      . ..| ||||||| |..||. .||.  .|
flefidellalspggpvlVHCsaGvgRtgtlvaaylml
subfamily_MTMR14_pd Subfamily MTMR14 409-490 8.4e-10 30.0 In-house 262-347 (357) alignment 
Range on Protein: 409-490
Range on HMM: 262-347/357.0
TVDREG-RPVLVHCSDGWDRTPQIVALAKILLD---PYYRTLEGFQVL---VESDWLDFGHKFGDRCGHQENVedqNEQCPVFLQWLDS
 |  ..   .||||  ||||||  |.| .. |      ...|.  ..|   |  ||. |||.. ||  . |..      |  .|....|
yvkededsGllvhcisGWdrtPlfvsllrlslWadglihqslsaaellyltvaydWflfghqlpdrlkkgeei...lffcfdvlkfits
subfamily_pats1_pd Subfamily pats1 481-565 6.2e-24 76.3 In-house 553-637 (691) alignment 
Range on Protein: 481-565
Range on HMM: 553-637/691.0
CPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPSSD
 |.|.|.|| | || |.||  ||||| .|. ||....|  .|.|| ..  ..  |...||. |.|.. .  . .| |.|| .|..
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinqnksrfinllykhsas
FYVE FYVE zinc finger 1124-1188 2.7e-19 58.9 Pfam-A 2-68 (69) alignment 
Range on Protein: 1124-1188
Range on HMM: 2-68/69.0
RWVPDHMASHCYNCDCEFWLAKRRHHCRNCGNVFCAGCCHLKLPIP--DQQLYDPVLVCNSCYEHIQ
.||.|. |..| .|. .| | .||||||.||.|.|. |.. ... .  ...  ..| ||..|.|...
kwvddaeakkCeiCakkFsltrrrhhCrlCGkvvCskCsskrvekleeesaeekevrvCkeCleels