Gene MTMR4 in Homo sapiens

Synonym: FYVE-DSP2, ZFYVE11, MTMR4

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR3
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP054_AA protein Get Run
HsapP054_AA_166-591 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Myotubularin-like phosphatase domain 140-534 2.2e-148 486.7 Pfam-A 1-352 (353) alignment
Myotubularin-like phosphatase domain 140-534 2.2e-148 486.7 In-house 1-352 (353) alignment
subfamily_MTMR3_pd Subfamily MTMR3 145-586 2.1e-233 767.9 In-house 1-441 (442) alignment
Range on Protein: 145-586
Range on HMM: 1-441/442.0
AYHAWCLGLTEEDQHTHLCQPGEHIRCRQEAELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAI
|||||.|  .|......|.............|..|.||||...||.|..||..|||.|||.||.||..|||..|..||||||.||.|.||.|| .|||..
ayhawkleeeekerdgfllraasvaeeklkeeverlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavl

ARCSQPEISWWGWRNADDEYLVTSIAKACALDPGTRATGGSLSTGNN---DTSEACDADFDssltaCSGVESTA-APQKLLILDARSYTAAVANRAKGGG
|||||||..|.|||||.||.|...|||||||| |..|.|..||.|..   |.|.|.||..|     .|. ||.| ...||||.||||||||.||||||||
arcsqPevgwlgWrnaedekllkaiakacaldagekakgeklsngkakkkdvsdaldaead.....aseeeslaeekkkllivdarsytaafanrakgGG

CECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLD
||.|||||||||||.|.|||||.|.||..|||..||.||.||||||||.|||||.|||.||||| |...||.||||||||||||||||.|||||||.|||
celeeyypncevvflglanihavrksfnslrallsqspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllld

PYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKR
|||||||||.||||..|||||||| |||||.|||.|.||.|||||||||.|||| .|||..|||||||||||||||||||.||||||. .|||......|
pyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekereeekvker

TCSVWALLRAGNKNFHNFLYTPSSDMVLHPVCHVRALHLWTAVYLP
|.|||.|||| .|...|.||......||.|...||.|.||..|||.
tlsvWsllrakekeyrnllykekteavllpavsvrelklwsevyle

0040695 (Phosphotyrosine protein) phosphatases II 171-587 1.2e-147 485.5 In-house 11-385 (388) alignment
Range on Protein: 171-587
Range on HMM: 11-385/388.0
CRQEAELARMGFDLQnVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIA
   . || |.|..|. .||.|..|.||.||||||..|.||..|.|..|..||.|||..||||..||| .|||.. |.||| ......|. .|| |...| 
ydilrelkrlglgld.lwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledeklleail

KACAldpgtratggslstgnndtseacdadfdssltacsgvestaAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYL
|..                                           ..||||.|.|... |.||||.|||.|.|..|||.|..|... ||| .|.|.| |
kllp.........................................nlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqkl

RAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGH
. .| ..|| .|.||.||...||......|..|||... .|... .||||||||||||.|...|| .|||||||||||||||.| .|| ||||| ||.||
ldaclnvpdslnllslleesgwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlgh

QENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPSSDMVLHP
 |.. |..| .||||..|| |.|||.|||. ||||| .|. |..|.|||..|||| |...|| . ....||.|.| .|   .. |.|.|| |||..||.|
leseidskefsPvFllFLdcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkseflnplYdpsslevllp

VCHVRALHLWTAVYLPA
...|. |.||. .||. 
slsvldlllWleyylrw

subfamily_MTMR6_pd Subfamily MTMR6 172-273 3.2e-21 68.1 In-house 23-122 (397) alignment
Range on Protein: 172-273
Range on HMM: 23-122/397.0
RQEAELARMGFDlQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPeISWWGWRNADDEYLVTSIAK
  .||..|||   .. | ....| .|.|| .||..| ||  .| . |   . ||| .|.||. | | .| ||| ||||| .|    |  .|| |.  | |
dlkaeytrmgvp.nekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqp.lsgfsarcledeklleairk

AC
| 
an

subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 173-584 1.1e-125 412.0 In-house 21-399 (404) alignment
Range on Protein: 173-584
Range on HMM: 21-399/404.0
QEAELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKA
.| | .|.|.  .  ||.|.|||.|.||..||. | ||  |.|.||..|||||| .||||...||  ... |.|.||| .   . |  .||.|. || ||
aeeEykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqplvGltksrseedEklinsirka

CALDPgtratggslstgnndtseacdadfdssltacsgvestaapqKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRA
..  .                                         .|.|||||... ||||.||| |.|  . | |||. |....||| .|.|.. |. 
ktqle.........................................tlyildarpkanavansakgagyedisryenceieflnienihelreslkklkk

VCSQMPDP-SNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHq
..... .  .|||| |||..||.|.. .|...  ...... |. .||||||||||||.|...|...||||||||.|||.||.| .||.||||| .|.|. 
avnsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigq.

ENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPSSDM---VL
.. ....|. |.|||..| |.||.||||  ||||| ||.|.... ||| .|||| ..  ||...|..| | |.|||| | .... | ||  ..       
ttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWalleankseylnplyilekkeqkeni

HPVC-----HVRALHLWTAVY
.  .     ... ..||   |
tssessssadikliklWseyy

subfamily_MTMR1_pd Subfamily MTMR1 173-273 3.1e-26 84.6 In-house 12-112 (389) alignment
Range on Protein: 173-273
Range on HMM: 12-112/389.0
QEAELARMGFDLQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKA
 |||| |.|   ...||....|..|.||..||..| ||  ..|..|..||.||| .|.||... . .|.|.|.|.|||     | |...|| ... | .|
peaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskedekylqailea

C
 
n

subfamily_MTMR9_pd Subfamily MTMR9 173-273 9.3e-24 76.2 In-house 20-119 (393) alignment
Range on Protein: 173-273
Range on HMM: 20-119/393.0
QEAELARMGFDlQNVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKA
.| |.|..    .. ||.|..| |.|.|.|||....||  |.|.||. .|.||.  |.||  |.| ...|.. |.||| ..  | |  .|| |. .. |.
renefaklisa.sdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgssgkrckedekllnlvlkk

C
 
l

subfamily_pats1_pd Subfamily pats1 176-246 1.5e-06 18.9 In-house 14-82 (691) alignment
Range on Protein: 176-246
Range on HMM: 14-82/691.0
ELARMGFDLQNVWRVSHINSNyKLCPSYPQKLLVPVWITDKELENVASFRSWKrIPVVVYRHLRNGAAIAR
|  |.. ||   ||| .. |. .|.  ||.. |||  ..|. |   .  || | |||. . .  | ... |
egqrlkldldkdwrvveflsr.dlseiyPkrilvPklvsdellvsyvrkrssk.iPvlswsnqnnksslfr

subfamily_MTMR5_pd Subfamily MTMR5 177-251 3.8e-17 54.3 In-house 14-94 (483) alignment
Range on Protein: 177-251
Range on HMM: 14-94/483.0
LARMGFDLQ------NVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPE
  |.|...       . .|.|..|..|..| |||  ..||. . |.... ||     .|.|||..|| ||.| . | ...|
ykRlGlgalngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfe

subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 186-272 7.8e-18 56.4 In-house 40-126 (405) alignment
Range on Protein: 186-272
Range on HMM: 40-126/405.0
NVWRVSHINSNYKLCPSYPQKLLVPVWITDKELENVASFRSWKRIPVVVYRHLRNGAAIARCSQPEISWWGWRNADDEYLVTSIAKA
  |.|. || .||.| ||.  |.|    .||.||.. ||||  ||| . ..     |.|.||||| .     |  .||. ..|.| .
cywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqplvgierarcpedelycsslals

subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 308-585 2.3e-72 236.0 In-house 120-402 (405) alignment
Range on Protein: 308-585
Range on HMM: 120-402/405.0
CSGVESTAAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLR-AVCSQMPDP-------SNWLSALESTKWLQHLSVM
|| .  .|  . | ..|||    |.|| |.| | |    |||| .||| . ||| ||.|.. |  |. |   |          .   .| | |. |.  .
csslalsapsktlylidarpklnaiantangagfenihnypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwishiksi

LKAAVLVANTVDrEGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEdqNEQCPVFLQWLDSVHQLLKQFP
|.|| . |. .   |  .|||||||||||||| .|..|||||||||. |||||.| .|| |||||  | ||    |  .|. |.| |.|| . |||.|||
leaatfsaelil.kgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgne..eerspifqqfldccfqllsqfp

CLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPSSDMVLHPVCHVRALHLWTAVYL
 ||||  ..|. . .  .|| ||||| |   .| . ..  .| |.|. ..   ..| |  | |     ..|  . |.| || |.|.
llfeftpslllfisdnihsckygtflnncekdrvqdqvktktisiwsevnlnvnkflnpyynpqdiqsikpklysrclelwkacym

subfamily_MTMR1_pd Subfamily MTMR1 312-585 1.3e-107 352.4 In-house 110-384 (389) alignment
Range on Protein: 312-585
Range on HMM: 110-384/389.0
ESTAAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVD
|. |  .||||||||| ..||||.|||.| | ||.| |.|..|. ..|||..|.|.. |....    | ..|||||||||||.|....|..|| ....|.
eanaqsekllildarssvnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvlpnvddkkwlsalestkWlehiklilagavkivekve

REGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVK
.|   |||||||||||| |...||..|||.||||.|||.||.| .|| ||||| .| || .. . ..|. |||||..|.|.|| .|||. ||||| ||. 
tektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFefneefLit

LVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPS-SDMVLHPVCHVRALHLWTAVYL
|..| ||||.|||| |.  ||.|......| |.|. . . ...| | ||... .. || |.. .| |.||.  ||
lldhlysclfGtflfnsekervkekvkektvslwsyvnsskeeftnplyaeelekkvlypkaslrrlelWkeyyl

subfamily_MTMR6_pd Subfamily MTMR6 315-584 3.4e-94 308.3 In-house 123-392 (397) alignment
Range on Protein: 315-584
Range on HMM: 123-392/397.0
AAPQKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVC-SQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDRE
.  . | ..|.|    |.||.|.| | | |. | |..  |.|. ||| .|.| | |  |.  . .. |..||.|||..||.|.  .|.|....|..| .|
pnsellyvvdtrpklnalankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksvseflsglessgwlkhikavldasifiakavaee

GRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQEnvEDQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLV
|  |||||||||||| |...||..||||||||..||.||.| .|| ||||| .|||. .  ||. |  |.|.|.|..| |||.|||. |||||.||..| 
gasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGlld..edskevsPiftqflecvwqlleqfpkafefnerfllelh

QHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPSSD-MVLHPVCHVRALHLWTAVY
.| ||| .||||.|.  .|.. .. .|| |.|| | . .... | ||.....  ||.|  .. ||.||.|.|
dhvyscqfGtflgncekdrrdlklkertkslwayllerkddylnplykaetekevlkpdtapaalklwraly

subfamily_MTMR9_pd Subfamily MTMR9 318-586 1.2e-72 237.2 In-house 120-391 (393) alignment
Range on Protein: 318-586
Range on HMM: 120-391/393.0
QKLLILDARSYTAAVANRAKGGGCECEEYYPNCEVVFMGMANIHAIRNSFQYLRAVC-SQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRP
.| ||.| || .|| ..|.|||| | |. |.. . .   ..... | .|.. |  .|  .  . ...|| ||...||...  .|.||. ||...|.|| |
kkGlivdtrsksaaenarskgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsqvadlleaalvvaqcldeegap

VLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVE-DQNEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQH
|.|| ..| | | |...||...|||..||..||. |.| .|.  || |  |. .    |  .... |||| .||.|.|.|.|||. ||||| .|. | .|
vvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfeh

TYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGN--KNFHNFLYTPsSDMVLHPVCHVRALHLWTAVYLP
.||. .||||..|  ||.. .. |.| |.|. . . .  |.| | || .  . |. |  .  .|.||. .||.
syssqfgtflcdneaerkelklkkktvslwsyvnrpeklkqflnplyea.naeviwpsvapqslelWselylr

0040439 (Phosphotyrosine protein) phosphatases II 339-437 5.1e-09 31.6 In-house 92-202 (249) alignment
Range on Protein: 339-437
Range on HMM: 92-202/249.0
GGCECEEYYPNCEVVFMGMANIH--------------------AIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAvlvantvdREGRPVL
| . |..|.|. ... .|.  ..                       .|...|   .  .|| .   |  .  .... .  .|...        ..| |||
grekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel........pkggpvl

VHCSDGWDRTPQIVALAKI
||||.| .||. ..|.  .
VHCsaGvgRtGtfiaaylm

0045098 (Phosphotyrosine protein) phosphatases II 339-438 2.6e-08 29.1 In-house 102-230 (278) alignment
Range on Protein: 339-438
Range on HMM: 102-230/278.0
GGCECEEYYPNCEVVFMGMANIHAI-----------------------------RNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANT
| . |..|.|. ...  |.  .. .                              . ..||       |. . . | || ......    |   .|. ..
grekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssll

VDREGRPVLVHCSDGWDRTPQIVALAKIL
.. .| ||||||| |..||  .||.  .|
lldsggpvlVHCsaGvgRtGtlvaaylml

0051429 (Phosphotyrosine protein) phosphatases II 342-440 1.8e-09 33.2 In-house 62-176 (272) alignment
Range on Protein: 342-440
Range on HMM: 62-176/272.0
ECEEYYPNCEVVFMGMANIHAIRNSFQYLR------------------AVCSQMPDPSNWLSALESTKWLQHL---SVMLKAAVLVANtvdreGRPVLVH
 |. | |....... . . .| . .. .||                  ..    .. . ..  |  | |. |    . .|..  |...     |.|||||
kcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.....ggpvlvH

CSDGWDRTPQIVALAKILLD
|| |.|||  .|||  .||.
CsaGkdRTGtvvallllllg

0041856 (Phosphotyrosine protein) phosphatases II 343-435 1.2e-06 23.8 In-house 67-130 (182) alignment
Range on Protein: 343-435
Range on HMM: 67-130/182.0
CEEYYPNCEvvfmgmanihaIRNSFQYLRAVCSQMPDPSnWLSALESTKWLQHlsvmlkaavlvantvdrEGRPVLVHCSDGWDRTPQIVALA
.| |.|. .            |. .|||.  .  .. |. . ..|.  .. ..                 ||.||||||| | .||. .||. 
eelywpell...........erlgiqylylpwpDhgvpd.ldelldfieevle.................eggpvlVHCsaGvgRtgtlvaay

subfamily_MTMR5_pd Subfamily MTMR5 345-581 1.2e-62 204.3 In-house 223-476 (483) alignment
Range on Protein: 345-581
Range on HMM: 223-476/483.0
EYYPNCEVVFMGMANIHAIRNSFQYLRAVCSQM---PDPSN--WLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILL
| . ..|.. . . .| ....||. |. .|.      ....  .|...|   ||| .| .|. .. |.. .| .|  |||   |||| | |...||..||
evdskaefipvelveirqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqlll

DPYYRTLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQnEQCPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNI--
||||||||||.|||| .|| |||.| .|. .... .      |||||.|| |||. .|||  ||||. .|  |  |  |. . ||| .   || . ..  
dpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqss.gfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesglly

--------YKRTCSVWALLRAGNKN---FHNFLYTPSSDMVLHPVCHVRALHLWT
         | . |||  . . .|.   |.||||.|....||.| ..| .|..|.
eekaekrakkagksvwdyidrqhkrspifynflyspdesevlrPssnvsslkvWd

0049772 (Phosphotyrosine protein) phosphatases II 347-435 1.4e-07 27.0 In-house 155-233 (314) alignment
Range on Protein: 347-435
Range on HMM: 155-233/314.0
YpnCEVVFMGMANIHairnsfqylrAVCSQMPDPSNWLSALESTKWLQH---LSVMLKAAVLVANTVdREGRPVLVHCSDGWDRTPQIVALA
.  .| ... .....           ..   ......   .  . .  .   |. ...... . ... ..|.||||||..|..||.  |..|
g..neptaadlellk..........eelydpelferlgikylripvpDgsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaa

subfamily_pats1_pd Subfamily pats1 349-478 1.9e-25 81.4 In-house 335-467 (691) alignment
Range on Protein: 349-478
Range on HMM: 335-467/691.0
NCEVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSVMLKAAVLVANTVDrEGRPVLVH-CSDGWDRTPQI---VALAKILLDPYYR
 ....|. .   . ... |  |     .. .. .  . .|  ||.  . ..|.||| |.| .| ||. ||..  .|. . . ..    .||..|.||.||
ssniiflslPtrekveerffdllqsilsldgsddewkeieeskwvdsvkllleaavkvsnlld.eGssvllknsidsPlieldlasisslaqvlsdPfyr

TLEGFQVLVESDWLDFGHKFGDRCGHQENVEDQN
||.||.||.| .||..|. | ... |.|. . .|
tldGfkvliekewlsyGfPfskinyhkesddlnn

0044763 (Phosphotyrosine protein) phosphatases II 351-435 5e-09 31.6 In-house 60-131 (178) alignment
Range on Protein: 351-435
Range on HMM: 60-131/178.0
EVVFMGMANIHAIRNSFQYLRAVCSQMPDPSNWLSALESTKWLQHLSvmlkaavlvantvDREGRPVLVHCSDGWDRTPQIVALA
|  |...   .  ....|||.  .. ...|.     || .......              |..|.||||||| |..|.. .||. 
elgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeal.............dekggpvlVHCsaGvgRsgtlvaay

subfamily_MTMR10_pd Subfamily MTMR10 357-535 2e-46 150.5 In-house 123-305 (380) alignment
Range on Protein: 357-535
Range on HMM: 123-305/380.0
MANIHAIRNSFQYLRAVCSQMPD------PSNWLSALESTKWLQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTLEGFQ
...|. . .... ||..|             .|||.||.|.||.  ...|. |. ...|| ...|.|..  |.| |    .  || ..|||.|||..|||
lpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGfq

VLVESDWLDFGHKFGDRCGHQENVEDQNEqcPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKR
 |..  |   ||.| ||.||  . |....  ||||  || |.|||.|||  |||.| ||..|. ...|....|||.|.. .|.| 
sliqkewvaaghpfldrlghikpsekses..pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlka

0051082 (Phosphotyrosine protein) phosphatases II 359-439 7.6e-08 27.6 In-house 57-117 (151) alignment
Range on Protein: 359-439
Range on HMM: 57-117/151.0
NihairnsFQYLRAVCSQMPDPSnwlsalestkwlqhLSVMLKAAVLVANTVDRE-GRPVLVHCSDGWDRTPQIVALAKILL
.       ...|.  .  .|||.              |.....|.. . . ...  . ||||||| |..||  .|||  .||
g.......ievlhipildwpdpg..............lplsfdavleflellldkkngpvlvHCsaGkgRTGtlvalylmll

0048179 (Phosphotyrosine protein) phosphatases II 366-437 6.7e-07 24.7 In-house 49-106 (144) alignment
Range on Protein: 366-437
Range on HMM: 49-106/144.0
SFQYLRAVCSQMPDPSNWLSALESTKWLQHLsvmlkaavlvantvDREGRPVLVHCSDGWDRTPQIVALAKI
 .|||.  .  .. |. .   ||  ......               .||.||||||| | .||. .||.  .
giqylhlpwpDhgvpdllellleflefieea..............leeggpvlVHCsaGvgRtgtlvaaylm

0039614 (Phosphotyrosine protein) phosphatases II 371-437 4.2e-07 25.2 In-house 102-245 (297) alignment
Range on Protein: 371-437
Range on HMM: 102-245/297.0
RAVCSQMPDPSN----------------------------------------------WLSALE------------------------STKWLQ-----H
. ...| | |..                                              .|.  .                         |.|       .
kfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvpps

LSVMLKAAVLVANTVDR--EGRPVLVHCSDGWDRTPQIVALAKI
|...|..  || . . .  .|.|||||||.| .||  ..|.  .
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylm

0040438 (Phosphotyrosine protein) phosphatases II 391-437 4.7e-06 21.6 In-house 181-232 (317) alignment
Range on Protein: 391-437
Range on HMM: 181-232/317.0
KW-----LQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKI
 |      .... .|.   .| .  ...| |||||||.| .||  ..|.  .
gWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylm

0051299 (Phosphotyrosine protein) phosphatases II 391-437 8.9e-06 20.8 In-house 191-242 (288) alignment
Range on Protein: 391-437
Range on HMM: 191-242/288.0
KW-----LQHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKI
.|      .... .|.   || .     | ||.||||.| .||  ..||  .
nwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdll

0043336 (Phosphotyrosine protein) phosphatases II 394-437 4.3e-07 25.2 In-house 190-233 (278) alignment
Range on Protein: 394-437
Range on HMM: 190-233/278.0
QHLSVMLKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKI
 .|| .|.    | . .. .. |||||||.| .||  ..||  .
eslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyll

0045450 (Phosphotyrosine protein) phosphatases II 394-438 3.6e-06 22.4 In-house 212-258 (307) alignment
Range on Protein: 394-438
Range on HMM: 212-258/307.0
QHLSVMLKAAVLVANTVD--REGRPVLVHCSDGWDRTPQIVALAKIL
.... .|.   .| . ..  ..| |||||||.| .||. ..|.  .|
psfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylml

0049260 (Phosphotyrosine protein) phosphatases II 398-438 9.8e-07 24.1 In-house 72-113 (152) alignment
Range on Protein: 398-438
Range on HMM: 72-113/152.0
VMLKAAVLVANT-VDREGRPVLVHCSDGWDRTPQIVALAKIL
 .|. ..|. .    ..| ||||||| | .||. .||.  .|
qlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml

0048076 (Phosphotyrosine protein) phosphatases II 400-437 9.1e-07 24.2 In-house 67-104 (145) alignment
Range on Protein: 400-437
Range on HMM: 67-104/145.0
LKAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKI
| ...   ... .||.||||||| | .||. .||.  .
lleflefieealkeggpvlVHCsaGvgRtgtlvaaylm

0036282 (Phosphotyrosine protein) phosphatases II 400-441 3.8e-06 22.2 In-house 89-131 (174) alignment
Range on Protein: 400-441
Range on HMM: 89-131/174.0
LKAAVLVANTVDR-EGRPVLVHCSDGWDRTPQIVALAKILLDP
|..  .| . . . .|.||||||| | .||. .||.  .|   
lefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgl

0046846 (Phosphotyrosine protein) phosphatases II 401-439 4.7e-06 22.0 In-house 96-134 (176) alignment
Range on Protein: 401-439
Range on HMM: 96-134/176.0
KAAVLVANTVDREGRPVLVHCSDGWDRTPQIVALAKILL
  ..   ... .||.||||||| |  ||. .||.  . |
lellefirealkeggpvlVHCsaGigRtgtlvaayllel

0042113 (Phosphotyrosine protein) phosphatases II 404-437 5.5e-06 21.5 In-house 164-199 (245) alignment
Range on Protein: 404-437
Range on HMM: 164-199/245.0
VLVANTVD--REGRPVLVHCSDGWDRTPQIVALAKI
.  ....    .. |||||||.| .||  ..|.  .
lefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

PTPc_DSPc_SM00012 405-511 1e-09 33.9 In-house 38-99 (105) alignment
Range on Protein: 405-511
Range on HMM: 38-99/105.0
LvantvdreGRPVLVHCSDGWDRTPQIVALAKILLDPYYRTlegfqvlvesdwldfghkfgdrcghqenvedqneqcpVFLQWLDSVHQLLKQFPCLFEF
         . ||.||||.|..|| ..|||. .| . ...|                                      ...... |..| || | ....
s........skpvvVhCsaGvgRtgtfvaldillqqleket.....................................kevdifqivkelrkqRpgmvqt

NEAFLVK
.| .|. 
eeqylfl

0043147 (Phosphotyrosine protein) phosphatases II 406-438 1.2e-06 23.9 In-house 87-124 (172) alignment
Range on Protein: 406-438
Range on HMM: 87-124/172.0
VANT-----VDREGRPVLVHCSDGWDRTPQIVALAKIL
. .      . ..| ||||||| |..||. .||.  .|
flefidellalspggpvlVHCsaGvgRtgtlvaaylml

subfamily_MTMR14_pd Subfamily MTMR14 409-490 8.4e-10 30.0 In-house 262-347 (357) alignment
Range on Protein: 409-490
Range on HMM: 262-347/357.0
TVDREG-RPVLVHCSDGWDRTPQIVALAKILLD---PYYRTLEGFQVL---VESDWLDFGHKFGDRCGHQENVedqNEQCPVFLQWLDS
 |  ..   .||||  ||||||  |.| .. |      ...|.  ..|   |  ||. |||.. ||  . |..      |  .|....|
yvkededsGllvhcisGWdrtPlfvsllrlslWadglihqslsaaellyltvaydWflfghqlpdrlkkgeei...lffcfdvlkfits

subfamily_pats1_pd Subfamily pats1 481-565 6.2e-24 76.3 In-house 553-637 (691) alignment
Range on Protein: 481-565
Range on HMM: 553-637/691.0
CPVFLQWLDSVHQLLKQFPCLFEFNEAFLVKLVQHTYSCLYGTFLANNPCEREKRNIYKRTCSVWALLRAGNKNFHNFLYTPSSD
 |.|.|.|| | || |.||  ||||| .|. ||....|  .|.|| ..  ..  |...||. |.|.. .  . .| |.|| .|..
sPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinqnksrfinllykhsas

FYVE FYVE zinc finger 1124-1188 2.7e-19 58.9 Pfam-A 2-68 (69) alignment
Range on Protein: 1124-1188
Range on HMM: 2-68/69.0
RWVPDHMASHCYNCDCEFWLAKRRHHCRNCGNVFCAGCCHLKLPIP--DQQLYDPVLVCNSCYEHIQ
.||.|. |..| .|. .| | .||||||.||.|.|. |.. ... .  ...  ..| ||..|.|...
kwvddaeakkCeiCakkFsltrrrhhCrlCGkvvCskCsskrvekleeesaeekevrvCkeCleels