Gene SBF1 in Homo sapiens

Synonym: CMT4B3, DENND7A, MTMR5, C22:RP4-579N16.2, SBF1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Myotubularin
Subfamily MTMR5
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP055_AA protein Get Run
HsapP055_AA_1118-1636 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
uDENN uDENN domain 25-86 3.2e-25 77.4 Pfam-A 2-65 (65) alignment 
Range on Protein: 25-86
Range on HMM: 2-65/65.0
GQILQRFPEKDW-EDNPFPQGIELFCQPSGWQLCPER-NPPTFFVAVLTDINSERHYCACLTFW
..||..|||||. ||.|.|. |..||.| |......| ..|.||. ||||....|.|..||.|.
pkildqfPekdeeedeplpkaipmFCfPeglnfvtsreqkpeffsfvLTdedgsriyGfClrfl
DENN DENN (AEX-3) domain 130-310 3.3e-57 182.7 Pfam-A 2-184 (185) alignment 
Range on Protein: 130-310
Range on HMM: 2-184/185.0
APKTLVLVSRLDHTEVFRNSLGLIYAIHVEGLNVCLENVIGNLLTC-TVPLAGGSQRTISLGAGDRQVIQTPLADSLPVSRCSVALLFRQLGITNVLSLF
.||.|...|||...|.|.. |  ..  . .. .. ||..| |||.. ..| .| .....||.. .....|.| ...||.. ...  |||.|.|.|||.||
ipkalcilsrlpffelfkkiLkalekrlksssklplesfianlllevplPapgktlklkslsvkekillqrpssselPledvdleelfrcLsienvlqlf

CAALTEHKVLFLSRSYQRLADACRGLLALLFPLRYSFTYVPILPAQLLEVLSTPTPFIIGVNAAFQA-ETQELLDVIVADLDG
.|.|.|.....||....|| .... |.|||.||... .|.|.|||.||.||..||||||||. .... |...| ||...||| 
eavLlErriillSeklarLtsvaealvallyPlkWqhiyiPvlpaslldvleaPtPfiiGvesslleleekpledvvlvDldt
SPA Stabilization of polarity axis 221-314 7.6e-07 16.3 Pfam-A 12-110 (113) alignment 
Range on Protein: 221-314
Range on HMM: 12-110/113.0
ITNVLSLFCAALTEHKVLFLSRSYQR--LADACRGLLALLFP---LRY-SFTYVPILPAQLLEVLSTPTPFIIGVNAAFQAETQELLDVIVaDLDGGTVT
. .|  |. | ||. ....||.. .   .....  |..|  |   ||. . .. |..  . |. |.  . .|.||  .. .|..|. ||.. ||| |.|.
tpkvillinalltqkriivlsteasadevcefvLalcllvspgavlrgfknnsfPyvdlskldklekvpgyIaGvtNPiFeeqeewWDvlc.dldsgkvi
dDENN dDENN domain 365-433 6.1e-19 57.2 Pfam-A 2-68 (68) alignment 
Range on Protein: 365-433
Range on HMM: 2-68/68.0
DKELRAVFLRLFAQLLQGYRWCLHVVRIHPEpvIRFHKAAFLGQRGLVEDDFLMKVLEGMAFAGFVSER
|...|..|||.||.||.||| .|.  | .||  . |.|.||| .|   . .||...|| ..|| |..||
dqqvreaFlrffasllggYrnflrkerkspe..vsFqkeaFlksrskshrsFlsqfletqmFaeFieer
SBF2 Myotubularin protein 541-765 2.6e-109 353.1 Pfam-A 1-225 (225) alignment 
Range on Protein: 541-765
Range on HMM: 1-225/225.0
PSGPPMTAILERCSGLHVNSARRLEVVRNCISYVFEGKMLEAKKLLPAVLRALKGRAARRCLAQELHLHVQQNRAVLDHQQFDFVVRMMNCCLQDCTSLD
|.||....|.|.... . ||||||||.||||||.|. |.|||||.|||||||||..||| .|..||..|||||||||||||||.|||.||..|||... |
pagptvasivektkstvensarrlEvlrnCisyiFdnkileakKslpAvlralkskaaRlalceelekhvqqnravLdhqqFDlvvrlmNkaLqddsakd

EHGIAAALLPLVTAFCRKLSPGVTQFAYSCVQEHVVWSTPQFWEAMFYGDVQTHIRALYLEPTEDLAPAQEVGEAPSQEDERSALDVASEQRRLWPTLSR
|.|.|||||||..|||||||.||.||||.|||.|.||...|||||.|| .||..|..|||| ..  .  ..  .. |...|.|||..|..| |.|||||.
eygvaaallplssafcRKLsegvsqfaYtcvqdHpvWknqqFWeatfyqevqkaikelylekkseskkkkktesslskkeeksaleiaadqlrkwptlsk

EKQQELVQKEESTVFSQAIHYANRM
|||.|||.||||||.|||||.|||.
ekqkelvkkeestvysqaihfanrl
GRAM GRAM domain 884-968 1e-14 45.2 Pfam-A 2-68 (69) alignment 
Range on Protein: 884-968
Range on HMM: 2-68/69.0
KLLRPRLLPGEECVLDGLRVYLLPDgreegaggsaggpaLLPAEGAVFLTTYRVIFTGMPTDPLVgeqvVVRSFPVAALTKEKRI
|. ..  ||.||..|| ...|| ..              ..|..|...||.||.||.....|...    ||...|.|.... ...
kfrktfklppeEkllddyaCylsts..............kgpvqGrlYlTnyrliFrSdklddsk....vvvvipladikrveks
Myotub-related Myotubularin-like phosphatase domain 1117-1560 2.4e-113 371.5 Pfam-A 18-352 (353) alignment
Myotub-related Myotubularin-like phosphatase domain 1117-1560 2.4e-113 371.5 In-house 18-352 (353) alignment
0040695 (Phosphotyrosine protein) phosphatases II 1118-1626 1.4e-111 366.8 In-house 4-385 (388) alignment 
Range on Protein: 1118-1626
Range on HMM: 4-385/388.0
TMSSLVERACCRDYQRLGLGTlssslsraksEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSGGLHGkg
.. . ......|...|||||.          ...||| ||..| .|.|||.||.||.|..|. |.||.|.....|.||...|  ...||||||. ...  
leegwslydilrelkrlglgl..........dlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplv..

vvglfkaqnapspgqSQADSSSLEQEKYLQAVVSSMPryadasgrntlsgfssahmgshvpsprarvttlsnpmaasasrrtaprgkwgsvrtsgrssgl
               ... |.|||.||.|.|.....|                                                               
...............glllsrsledeklleailkllp...............................................................

gtdvgsrlagrdalappqanggPPDPGFLRPQRAALYILGDKAQLKGVRS-DPLQQWELVPIEVFEARQVKASFKKLLKACvpgcpAAEPSPASFLRSLE
                      ... ...   |  | .|  .|. .||.. |  ...||..... . ..|..|..|||.||        |.  ..| .||
......................nlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldac.....lnvpdslnllslle

DSEWLIQIHKLLQVSVLVVELLDSGSS-VLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTL-AGQSSGFTPVFLQFL
.|.|| .|. .|...||.|.|||.|.| |||  .||||.|.|..||.||| ||.|||||||. |.|||||||||.|..|  |.    .|..|.||||.||
esgwldliklilelavlivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFL

DCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLlyeekgerrgQVPCRSVWEYVDRLSKRtpvFHNYMYAPEDAEVLRPYSNVS
|||.|.. |||..|||....|.|| .|..| ||.|||..|..||.||..          .  ..|.|.|. . ...   |.|..| |.  |||.|...|.
dcvwqLlrqfPtaFeFnerlLlfLadhlyscrfgtFlfnsekerlelsv..........sertlslwsyllsrkse...flnplYdpsslevllpslsvl

NLKVWDFYTEET
.|..|. |. ..
dlllWleyylrw
subfamily_MTMR5_pd Subfamily MTMR5 1119-1627 4e-223 733.6 In-house 2-483 (483) alignment 
Range on Protein: 1119-1627
Range on HMM: 2-483/483.0
MSSLVERACCRDYQRLGLGTLSSSlsrAKSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSGGLHGKGV
...|.|||...||.|||||.|...   .|...|||| ||..|..|||||.|..||..|.|....||..|.||||.|||.||. |.||.|.||||...|||
veklaerayvqdykRlGlgalnga...skrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggfeskgv

VGLFKAQNAP--SPGQSQADSSSLEQEKYLQAVVSSMPRYADASGRNTLSGFSSAHMGSHVPSPRARVTTLSNPMAASASRRTAPRGKWGSVRtsgrssg
|||.|..|..  |...|...|.||||||||.|||..............|. ..|....|.... ||...| .|....|.|.... .||.....       
vgllksantqgsstsessessksleqekylkavvnevsklsalalnsslevslsvlasssssdkraalsteknaldisksdkasqggkgatlk.......

lgtdvgsrlagrdalappqaNGGPPDPGFLRPQRAALYILGDKAQLKGVRSDPLQQWELVPIEVFEARQVKASFKKLLKACVPGCPAAEPSPASFLRSLE
                    .. . .. .|| ..||||.||.|.|||.|.|.  ...|..|.|..|.|||||||||||.||.| ....|....|||.|.|
....................ennakeskklrarkaaLYvlgeksqlknvksevdskaefipvelveirqvkasfkkllraClpstaveeaesqsFlksve

DSEWLIQIHKLLQVSVLVVELLD-SGSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQSSGFTPVFLQFLD
||||| ||..|||.|. ||.||| .||||||.||||||.|.||.||.|||.||.|||||||..|||||||.|||||..|...||. |||||.||||||||
dseWlqqissllqlsgavvdlldlqgssvlvslEdGwdvtaqvsslaqllldpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqssgfaPvFlqFLD

CVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLLYEEKGERRGQVPCRSVWEYVDRLSKRTPVFHNYMYAPEDAEVLRPYSNVSN
|||||. |||..|||..||||||.||.||.|||||||||.|||.| |||||||.|.| .  ..|||.|.|| .||.|.|.|..|.|...|||||.||||.
cvhqvsrqfPlafefndfylkflayhsvsnrfrtfllDseyerlesgllyeekaekrakkagksvwdyidrqhkrspifynflyspdesevlrPssnvss

LKVWDFYTEETL
|||||.|.||.|
lkvWdyyleeel
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 1129-1211 4.2e-17 54.4 In-house 23-96 (404) alignment 
Range on Protein: 1129-1211
Range on HMM: 23-96/404.0
RDYQRLGLGTLSsslsraksePFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSG
..|.|||. . |         ..||| .|  | .| .|| ||.||.|..|. |..|.    ..|.||..||.  ..... || 
eEykRlgikses.........eWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRss
subfamily_MTMR9_pd Subfamily MTMR9 1147-1211 1.1e-17 56.3 In-house 30-94 (393) alignment 
Range on Protein: 1147-1211
Range on HMM: 30-94/393.0
KSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRcYRQN-RFPVVCWRSGRSKAVLLRSG
 |. .||| ||. ...| |||  .|||....|..|. ... .|.. |||| ...  . |||||||.
asdewRissvNknfkvcasypesvivPkaiddeelkasaa.freggrfPvLsylhketkavllrss
subfamily_MTMR3_pd Subfamily MTMR3 1147-1211 2.2e-16 52.6 In-house 40-104 (442) alignment 
Range on Protein: 1147-1211
Range on HMM: 40-104/442.0
KSEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSG
..| .||| ||  . .|.|||  ||||.|..|..|..|..    .|.|.| ||  ...||| |..
lkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcs
subfamily_MTMR1_pd Subfamily MTMR1 1148-1211 1.8e-14 45.9 In-house 24-87 (389) alignment 
Range on Protein: 1148-1211
Range on HMM: 24-87/389.0
SEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRSG
.. .||. .|. |..| .|| .|.||..|.|. |..|.. . ..|.||..| . ...||.||. 
eklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilras
subfamily_MTMR10_pd Subfamily MTMR10 1148-1210 2.9e-09 28.2 In-house 23-85 (380) alignment 
Range on Protein: 1148-1210
Range on HMM: 23-85/380.0
SEPFRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRS
|. .. . .| . | . ..|  ..||.|..|. ..|.|| |.. |||. .|  ....|.|. |
sdaivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrls
subfamily_MTMR6_pd Subfamily MTMR6 1151-1210 8.4e-07 20.6 In-house 38-97 (397) alignment 
Range on Protein: 1151-1210
Range on HMM: 38-97/397.0
FRISPVNRMYAICRSYPGLLIVPQSVQDNALQRVSRCYRQNRFPVVCWRSGRSKAVLLRS
. .. .|. | .| .||  | ||.|.. . |   |.   ..|.||. .   . .| . |.
wtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrc
subfamily_pats1_pd Subfamily pats1 1161-1209 6.7e-06 16.7 In-house 35-82 (691) alignment 
Range on Protein: 1161-1209
Range on HMM: 35-82/691.0
AICRSYPGLLIVPQSVQDNALQRVSRcYRQNRFPVVCWRSGRSKAVLLR
 ..  ||   .||..| |. |.   | .|. ..||..|     |..|.|
dlseiyPkrilvPklvsdellvsyvr.krsskiPvlswsnqnnksslfr
subfamily_MTMR1_pd Subfamily MTMR1 1357-1622 2e-58 190.5 In-house 131-382 (389) alignment 
Range on Protein: 1357-1622
Range on HMM: 131-382/389.0
GDKAQLKGVR-SDPLQQWELVPIEVFEARQVKASFKKLLKACVPGCpaaepSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSG-SSVLVGLEDGWDI
..||. ||   ..  .. ||. ... . . |..|.||| ....|       . ...| .||...|| .|...|. .| .|| ...  .||||  .|||| 
ankakgkgyeseeaYknaelifldihnihvvReslkklkelvlpnv.....ddkkwlsalestkWlehiklilagavkivekvetektsvlvhcsdGWDR

TTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTL-AGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLD
|.|..|| .|| |..|||.|||. |.|||||||||.|..| .|.    . .  .||||||.|||.|.. |||. ||| . .| .|  |  | .| |||..
taqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFefneefLitlldhlysclfGtflfn

SDYERIELGLlYEEkgerrgqvpCRSVWEYVDrlsKRTPVFHNYMYAPE-DAEVLRPYSNVSNLKVWDFY
|. ||..  . .|.           |.| ||.   ...  | | .||.| . .|| |   ...|..|  |
sekervkekv.kek.........tvslwsyvn...sskeeftnplyaeelekkvlypkaslrrlelWkey
subfamily_MTMR6_pd Subfamily MTMR6 1357-1620 1.7e-52 171.0 In-house 141-389 (397) alignment 
Range on Protein: 1357-1620
Range on HMM: 141-389/397.0
GDKAQLKGVRSD-PLQQWELVPIEVFEARQVKASFKKLLKACVPGCPAAEpspaSFLRSLEDSEWLIQIHKLLQVSVLVVELL-DSGSSVLVGLEDGWDI
 .||. ||  ..   .  ..  ... .   ...| .|||...   ... .    .||..||.|.||  |...|..|... . . ..| ||||   |||| 
ankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksvs....eflsglessgwlkhikavldasifiakavaeegasvlvhcsdGwdr

TTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHtLAGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDS
|.||.|| .|| ||.|||..|| .|.|||||||||.||.|  . | ..|  ..|.|.|||.|| |.  |||. |||.. .|  |  |  | .| ||| ..
taqvcslasllldpyyrtikGflvliekewlsfGhkfsercGl.ldedskevsPiftqflecvwqlleqfpkafefnerfllelhdhvyscqfGtflgnc

DYERIELGLlyEEKgerrgqvpCRSVWEYvdrLSKRTPVFHNYMYAPEDA-EVLRPYSNVSNLKVWD
. .| .| |  .|.          |.| |   | .|.  . | .| .|   |||.|  ....||.| 
ekdrrdlkl..ker........tkslway...llerkddylnplykaetekevlkpdtapaalklwr
subfamily_MTMR9_pd Subfamily MTMR9 1369-1620 4.8e-51 166.0 In-house 148-386 (393) alignment 
Range on Protein: 1369-1620
Range on HMM: 148-386/393.0
PLQQWELVPIEVFEARQVKASFKKLLKACVpgcpAAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDS-GSSVLVGLEDGWDITTQVVSLVQLLSD
  .||. .  .. . .... |. |||.||     .|. |  .||. || | || |...||.... |...||. |..|.|  |.| |.| ||.||.||. |
kysqwkkasrslesvasiqdslaklleacs....daglstdkflsrleksgwlsqvadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlild

PFYRTLEGFRLLVEKEWLSFGHRFSHRGAHTLAGQ--SSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLly
| .||..||  |.|.||.  || |..| ... | .  .   .|||| |||||.|.  |||..|||.. .| .|  |  | .| ||| |.. || ||.|  
pdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqilsqfpasFEFneelLillfehsyssqfgtflcdneaerkelkl..

EEKgerrgqvpCRSVWEYVDRlSKRTPVFHNYMYAPeDAEVLRPYSNVSNLKVWD
..|         .|.|.||.|  .... | | .| . .|||..|  .   |..|.
kkk........tvslwsyvnr.peklkqflnplyea.naeviwpsvapqslelWs
subfamily_MTMR10_pd Subfamily MTMR10 1379-1561 4.8e-41 132.8 In-house 122-305 (380) alignment 
Range on Protein: 1379-1561
Range on HMM: 122-305/380.0
EVFEARQVKASFKKLLKACVPGCPAA-EPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELL-DSGSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGF
|.   ..|.....|| . ||.  .         .| ||| ..||  .. .|. .. .|... ... ||..  ..| |.   | ||.||..||.|||..||
elpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilqesegrDlscvvaSLaqlmldphyrtisGf

RLLVEKEWLSFGHRFSHRGAHTLAGQSSGFtPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIEL
  |..||| . || | .|  |.   ..|   |||| |||||.| . ||| ||||.. .|  |  ...|  | |||..|. .| . 
qsliqkewvaaghpfldrlghikpsekses.pvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifltflfnseeqrlka
subfamily_MTMR3_pd Subfamily MTMR3 1382-1620 1.6e-57 188.3 In-house 214-436 (442) alignment 
Range on Protein: 1382-1620
Range on HMM: 214-436/442.0
EARQVKASFKKLLKACVpgcpaAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDS-GSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLV
    |. ||..| . .        | .. .| .||  .|| .. .||. .| ||| .|  | .|||   |||| |||.|.| .|| ||.|||||||. ||
nihavrksfnslralls.....qspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvlvhCsdGWdrttqivalakllldpyyrtleGfkvlv

EKEWLSFGHRFSHRGAHTL-AGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIElgllyeEKGERRgqvpCRS
|.|||.|||.|. | .|    ...   .|||||.||.|||.. |||  |||.. .|  |  |  |  | ||| .|  || |      || ..|      |
ereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtysclfGtflansekeree......ekvker....tls

VWEYVDrlsKRTPVFHNYMYAPEDAEVLRPYSNVSNLKVWD
||...    ..   ..| .|....  || |  .| .||.| 
vWsllr...akekeyrnllykekteavllpavsvrelklws
subfamily_Dicty-MTMR1-like_pd Subfamily Dicty-MTMR1-like 1383-1587 6.3e-52 169.1 In-house 167-358 (404) alignment 
Range on Protein: 1383-1587
Range on HMM: 167-358/404.0
ARQVKASFKKLLKACvpgcPAAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLD-SGSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVE
  ... |.||| ||.      .. .   .|  ||.|.|| .|..||..|  .|||.. ..|||||   |||| |.|..||.||| ||.|||.|||  |.|
ihelreslkklkkav....nsiiekeknwlselessrWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivlie

KEWLSFGHRFSHRGAHTLAGQSSGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIelgllyeekgERRGQVPCRSVW
|||||||| | .| ..|   .|. . |.||||.|||.|.  ||| .|||.. .|. . ..  | || ||| ||. ||           ... .    |.|
kewlsfGhkfaqRigqttekssdersPiflqFidcvyqltkqfptsFeFnekflikildalyscrfgtFLydsekeRq..........qnnlaketvslW

EYVDRL
 ...  
allean
subfamily_pats1_pd Subfamily pats1 1383-1498 1.1e-22 72.2 In-house 346-460 (691) alignment 
Range on Protein: 1383-1498
Range on HMM: 346-460/691.0
ARQVKASFKKLLKACVpgcpaAEPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSGSSVLVG-LEDGWDITTQV---VSLVQLLSDPFYRTLEGFRL
  .|.. | .||.. .        .. .  ...|.| |.  .  ||. .| |  ||| |||||.    |. .|. ..    || |.|||||||||.||..
rekveerffdllqsil.....sldgsddewkeieeskwvdsvkllleaavkvsnlldeGssvllknsidsPlieldlasisslaqvlsdPfyrtldGfkv

LVEKEWLSFGHRFSHRGAHT
|.||||||.|. ||..  | 
liekewlsyGfPfskinyhk
subfamily_Ank-MTMR1_pd Subfamily Ank-MTMR1 1405-1619 1.5e-40 131.2 In-house 197-397 (405) alignment 
Range on Protein: 1405-1619
Range on HMM: 197-397/405.0
EPSPASFLRSLEDSEWLIQIHKLLQVSVLVVELLDSGSSVLVGLEDGWDITTQVVSLVQLLSDPFYRTLEGFRLLVEKEWLSFGHRFSHRGAHtLAGQSS
| .   |   .|.. |. .|. .|. . .  ||.  | |.||   |||| | |. || |.| ||.|||. ||..|.|||||||||.|| |  | | |.  
estdmrfwgyieetgwishiksileaatfsaelilkgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlgh.lpgnee

GFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIElgllyeekgeRRGQVPCRSVWEYVDRLSKRtpvFHNYMYAPEDA
  .|.| |||||. |.  |||. |||.   | |.     | .. ||| . . .|..           . ..   |.|  |.   ..   | |  | |.| 
erspifqqfldccfqllsqfpllfeftpslllfisdnihsckygtflnncekdrvq..........dqvktktisiwsevnlnvnk...flnpyynpqdi

EVLRPYSNVSNLKVW
. ..|      |..|
qsikpklysrclelw
subfamily_pats1_pd Subfamily pats1 1504-1564 2.5e-11 34.7 In-house 550-610 (691) alignment 
Range on Protein: 1504-1564
Range on HMM: 550-610/691.0
SGFTPVFLQFLDCVHQVHLQFPMEFEFSQFYLKFLGYHHVSRRFRTFLLDSDYERIELGLL
 .|.|.|.|||| | |.. .||. ||| ...|  |  .  | || .|| .   .. |  .|
rsfsPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvl
PH PH domain 1791-1892 3.6e-13 39.9 Pfam-A 3-104 (104) alignment 
Range on Protein: 1791-1892
Range on HMM: 3-104/104.0
YEGTLYKKGAFMKPWKARWFVLDKtkHQLRYYDHRV---DTECKGVIDLAEVEAVAPGTPTMGapKTVDEKAFFDVKTTRR-VYNFCAQDVPSAQQWVDR
.||.|.||.   | || |.|||    ..| |.. .    . . ||.|.| ...     ..  |  .. ...  | .... .  | ..| .  ....||. 
keGyllkksellktwkkryfvLts..nyLlyfksskkksykapkgsiplndctvkkasstkfg..aqkesnnyfeitfknvesyllsaeseeerkrWvqa

IQSCLS
....||
lknlls
PH_11 Pleckstrin homology domain 1792-1826 4.8e-08 23.1 Pfam-A 2-36 (112) alignment 
Range on Protein: 1792-1826
Range on HMM: 2-36/112.0
EGTLYKKGAF-MKPWKARWFVLDKtKHQLRYYDHRV
.| |.|||.  .| ||.|||.| |   .|.||.   
kGylkkkgskllkgWkrrwfiLrk.dnvleYykspr