Classification
Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.
Protein sequence
Domains
Summary
Details
Domain | Domain Description | Range | Significance | Score | Source | Profile Range (length) | Alignment | ||
---|---|---|---|---|---|---|---|---|---|
GRAM | GRAM domain | 24-60 | 8.7e-06 | 16.6 | Pfam-A | 30-67 (69) | alignment | ||
Range on Protein: 24-60
Range on HMM: 30-67/69.0
ALGTLYLTATHVIFVENSPDPRK-ETWILHSQISTIEK
. |.|||| ...|| ...|. | | ..|. .||
vqGrlYlTnyrliFrSdklddskvvvvipladikrvek
|
|||||||||
Myotub-related | Myotubularin-like phosphatase domain | 108-449 | 1.9e-145 | 477.1 | Pfam-A | 1-352 (353) | alignment | ||
Range on Protein: 108-449
Range on HMM: 1-352/353.0
ELYCFSFNPMLDKEEREQ-GWVLIDLSEEYTRMGLPNHY-WQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRS
|||.||.... ....... .. || .|| |.||... |..|.||..|..|.|||..|.||||.. . .. ..||||..|.|||||. |.|.|...||
elyafsykakkselkdkkdslkiedlekeykrlglssskawriskvNenYelcesYPaklivPksisdeelkkvakfrskkRlPvlsyrhkengavlvRs
SQPLSGF-SARCLEDEQML-QAI--RKANPGSDFVYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVC-ELKSPSMSDF
||||.|. ..|. |||..| .|| .|.. .. ...||.|.||||.||.|.|.|.|.|.|||.....|.|||||||.|.||.|..|.| | ...|.|.|
sqplvgllnkrskedeklleaaisaekskkekkkllivDarkklnalankakgggveseenysqaelvflgienihvvreslkklreackeaneeseskf
LWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNL---DGDPKEISP
| ||.|.||.||.....| ....|.|..|..||||||||||||||||.|.|.|||||.|||..||.||.||.|.||||||..| | | . . || ||
lsslesskWLkhisslLkasalvvklveseessVlvhcsdGwDrtaqvvslaqllldpyyRtieGfqvLvekeWlsfGhkFaeRvghlkenkksskessp
VIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRE
| ||..||.||..|||.||||||.|||.. .| ||||||.||.||.|||.|
vFlqFlDcvyqllrqfptaFeFneefLiklvehlyscqfgtFLlnsekeree
|
|||||||||
Myotub-related | Myotubularin-like phosphatase domain | 108-449 | 1.9e-145 | 477.1 | In-house | 1-352 (353) | alignment | ||
Range on Protein: 108-449
Range on HMM: 1-352/353.0
ELYCFSFNPMLDKEEREQ-GWVLIDLSEEYTRMGLPNHY-WQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRS
|||.||.... ....... .. || .|| |.||... |..|.||..|..|.|||..|.||||.. . .. ..||||..|.|||||. |.|.|...||
elyafsykakkselkdkkdslkiedlekeykrlglssskawriskvNenYelcesYPaklivPksisdeelkkvakfrskkRlPvlsyrhkengavlvRs
SQPLSGF-SARCLEDEQML-QAI--RKANPGSDFVYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVC-ELKSPSMSDF
||||.|. ..|. |||..| .|| .|.. .. ...||.|.||||.||.|.|.|.|.|.|||.....|.|||||||.|.||.|..|.| | ...|.|.|
sqplvgllnkrskedeklleaaisaekskkekkkllivDarkklnalankakgggveseenysqaelvflgienihvvreslkklreackeaneeseskf
LWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNL---DGDPKEISP
| ||.|.||.||.....| ....|.|..|..||||||||||||||||.|.|.|||||.|||..||.||.||.|.||||||..| | | . . || ||
lsslesskWLkhisslLkasalvvklveseessVlvhcsdGwDrtaqvvslaqllldpyyRtieGfqvLvekeWlsfGhkFaeRvghlkenkksskessp
VIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRE
| ||..||.||..|||.||||||.|||.. .| ||||||.||.||.|||.|
vFlqFlDcvyqllrqfptaFeFneefLiklvehlyscqfgtFLlnsekeree
|
|||||||||
subfamily_MTMR6_pd | Subfamily MTMR6 | 109-509 | 5.6e-222 | 729.1 | In-house | 1-397 (397) | alignment | ||
Range on Protein: 109-509
Range on HMM: 1-397/397.0
LYCFSFNPMLDKEEREQGWVLIDLSEEYTRMGLPNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQP
||.||..|. ||||...|| |.||..||||||.||..|.|.|.|.||..||.||.|||||||||....||||||||..|.|||||..|.|.|.|||.|||
lyafsykpkkdkeekvsGwklldlkaeytrmgvpnekwtltdlnkdyelcdtyprelyvPksatkevlvgsskfrskgrlPvlsylhkeneaaicrcsqp
LSGFSARCLEDEQMLQAIRKANPGSDFVYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSG
||||||||||||..|.||||||| |...|||||||||||.||.|||||||||||||||||||.|||||||||.||||.|||.||||.|.|.||.|||.||
lsgfsarcledeklleairkanpnsellyvvdtrpklnalankaagkGyenednysnikfqfvgienihvmreslqkllevvelksksvseflsglessg
WLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQ
||.||||..||.|||||||.||||||||||||||||||||||.|||||||.|||.|||.|||||.|.||||||..|.|.||.|.||.||...||.|||||
wlkhikavldasifiakavaeegasvlvhcsdGwdrtaqvcslasllldpyyrtikGflvliekewlsfGhkfsercGlldedskevsPiftqflecvwq
LMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHSQtqGTLHLPTTPCNFmyKFWSGMYNRFE
|.||||.|||||||||.....|.||||||.||.|..|.||.||..|||.||||.|.....||||||..|.... ..|.. |.|... |.|...||||.
lleqfpkafefnerfllelhdhvyscqfGtflgncekdrrdlklkertkslwayllerkddylnplykaetek..evlkpdtapaal..klwralynrfd
K
|
k
|
|||||||||
subfamily_Dicty-MTMR1-like_pd | Subfamily Dicty-MTMR1-like | 110-507 | 7.1e-138 | 452.1 | In-house | 1-402 (404) | alignment | ||
Range on Protein: 110-507
Range on HMM: 1-402/404.0
YCFSFNPMLDKEEreQGWVLIDLSEEYTRMGLPNH-YWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQP
..||... . | .||.. | |||.|.|.... |..|..| ||..|..|| | ||.| . . .. ...|||. |.||||. ......| |||||
fafsysekksvle..dgwliydaeeEykRlgikseseWriskinsdyelcetYPkllvvPesisDeelkkvasfRskgRiPvlswrhrsknstitRssqp
LSGFS-ARCLEDEQMLQAIRKANPGSDFVYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDFLWGLENS
| | . .|. |||.....||||.. .. .|..|.|||.||.||.| |.|||. ..|.| . .| .||||| .|.||.|. .... . ...| ||.|
lvGltksrseedEklinsirkaktqletlyildarpkanavansakgagyedisryenceieflnienihelreslkklkkavnsiiekeknwlseless
GWLRHIKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGN-LDGDPKEISPVIDQFIECV
.|| ||| .. . |.. . .|. |||||||||||||.|..|.. |||||.|||..||.|||||.|.||||||..| |. . .| ||.. |||.||
rWldhiklllegskriveliekekssvlvhcsdgwDrtsqlsslsqllldpyyrtiegFivliekewlsfGhkfaqRigqttekssdersPiflqFidcv
WQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHSQTQGTLHLPTTPCNF---MYKFWSGM
.||..||| |||||.|||.| ...|||.||.||..|.||| . .... | |||| | .|. .|||||. ....... . . .. . . |.|| .
yqltkqfptsFeFnekflikildalyscrfgtFLydsekeRqqnnlaketvslWalleankseylnplyilekkeqkenitssessssadikliklWsey
YNRF
| |.
ylrw
|
|||||||||
subfamily_MTMR9_pd | Subfamily MTMR9 | 114-506 | 2.8e-106 | 347.9 | In-house | 4-391 (393) | alignment | ||
Range on Protein: 114-506
Range on HMM: 4-391/393.0
FNPMLDKEerEQGWVLIDLSEEYTRMGLPNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQPLSGFS
.... .. |.|. | .|.... . . | .|.||....|| |||... |||. . .. |..||. |||||||. |...| . ||||||.| |
yrsvatil..edgysafdrenefaklisasdewRissvNknfkvcasypesvivPkaiddeelkasaafreggrfPvLsylhketkavllrssqplcgss
-ARCLEDEQMLQAIRKANpgsDFVYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELKSPSMSDFLWGLENSGWLRH
|| |||..|... |.. ..|||| | |...|. | | | |..||..| . .|..... .||.|.||.|. .. |.. || ||.|||| .
gkrckedekllnlvlkkl...kkGlivdtrsksaaenarskgggietevkysqwkkasrslesvasiqdslaklleacsdaglstdkflsrleksgwlsq
IKAIMDAGIFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDP---KEISPVIDQFIECVWQL
......| .|....||||.|.|| ..| | | || |.| |.|||..||..||. |||..|| || |..| .. . |. .|| |..||.|.
vadlleaalvvaqcldeegapvvvhgeeGlDatlqvtsLaqlildpdaRtvrgfealiereWiqaGHPFasRaskvaaketkkklsgpvfllFLDcvyqi
MEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWK--NRADYLNPLFRAdhsqTQGTLHLPTTPCnfMYKFWSGMYNR
..|||..|||||..|| . .| ||.|||.|||....||.|||....| |||... . .. ..||||. | .. .. |. . ..||..| |
lsqfpasFEFneelLillfehsyssqfgtflcdneaerkelklkkktvslwsyvnrpeklkqflnplyea....naeviwpsvapq..slelWselylr
|
|||||||||
subfamily_MTMR1_pd | Subfamily MTMR1 | 123-508 | 9.2e-138 | 451.7 | In-house | 3-387 (389) | alignment | ||
Range on Protein: 123-508
Range on HMM: 3-387/389.0
REQGWVLIDLSEEYTRMGLPNH-YWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQPLSGFSA-RCLEDE
.|.|| . | ..|. |.||.|. |. ...|..| .||.||. |.|||... . . ....|||. |.||||.. | |.|.| |.||||.| |. |. |||
kedGWkvydpeaelerlgllneklWritklnkkyelcdtYpavlvvpkvvsdedlkkvaafrskgRlPvlswlnkenqavilrasqplvGlsgkrskede
QMLQAIRKANPGSDFVYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCElKSPSMSDFLWGLENSGWLRHIKAIMDAG
..||||..|| |. ....| |.. ||.||.| |||||.|..| |... |. |.||||.|.||.|. |.. . . ...| ||.. || |||.|...
kylqaileanaqsekllildarssvnavankakgkgyeseeaYknaelifldihnihvvReslkklkelvl.pnvddkkwlsalestkWlehiklilaga
IFIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLD--GDPKEISPVIDQFIECVWQLMEQFPCAFE
. |...|..| .|||||||||||||||. |.| ||||..|||..|| |||||.|.||||||..|.|. | ..| ||| |||.|||||..|||.|||
vkivekvetektsvlvhcsdGWDRtaqltsLamlllDsyyRtieGfevliekeWlsfGHkfkeRlghgdknssdaersPvFlqfiDcvwqltrqfptAFe
FNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHSqtQGTLhLPTTPCnFMYKFWSGMYNRFE
|||.||| . |.||| ||.||.||.|||.. |..|.| |||... ... .. |||.. . . . | |.. . . |. | |..
fneefLitlldhlysclfGtflfnsekervkekvkektvslwsyvnsskeeftnplyaeele..kkvl.ypkasl.rrlelWkeyylrwn
|
|||||||||
0040695 | (Phosphotyrosine protein) phosphatases II | 124-507 | 6.2e-148 | 486.4 | In-house | 5-385 (388) | alignment | ||
Range on Protein: 124-507
Range on HMM: 5-385/388.0
EQGWVLIDLSEEYTRMGLPNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQPLSGFS-ARCLEDEQM
| ||.|.| .|..|.||....|..|.||..| .|.||| |.||||.. ... ...|||..|.|||||....|.|...||||||.|.. |.||||..
eegwslydilrelkrlglgldlwrisivNenyelcpsYPallvVPksisdellkrvarfrskgriPvlsyrhpnngavllRssqplvglllsrsledekl
LQAIRKANPGSDFVYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCeLKSPSMSDFLWGLENSGWLRHIKAIMDAGIF
|.||.|..|.......||.||||||.||||.|.|.||||.|.|....|..|.||||.|.||||.|..| |..|.....|. ||.|||| .|| |... ..
leailkllpnlskllivdlrpklnalanralgggvenedaypnaeliflnipnihvvreslqklldac.lnvpdslnllslleesgwldliklilelavl
IAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDG--DPKEISPVIDQFIECVWQLMEQFPCAFEFN
|.| .. .. |||||||||||||.|..| | |||||.||||.||.|||||.|.|||||| .|.| |.. |.||.|||. .|..|||||. |||.|||||
ivklldlgnssvlvhcsdgwdrtsqlssLaqllldPyYRTleGFqvLiekeWlsfghkfadRlghleseidskefsPvFllFLdcvwqLlrqfPtaFeFn
ERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHSQtqgtlHLPTTPCNFMYKFWSGMYNRF
||.|... .|.|||.||.||.||.|||.||...|||.||| .|. .. ..||||. .... | .... ...|...|.|.
erlLlfLadhlyscrfgtFlfnsekerlelsvsertlslwsyllsrkseflnplYdpssle.....vllpslsvldlllWleyylrw
|
|||||||||
subfamily_Ank-MTMR1_pd | Subfamily Ank-MTMR1 | 126-482 | 6.7e-100 | 326.7 | In-house | 15-384 (405) | alignment | ||
Range on Protein: 126-482
Range on HMM: 15-384/405.0
GWVLIDLSEEYTRMGL-------PNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQPLSGFS-ARCL
|| . . .|| |. . | ||.....|..|..| ||.. | | . |. . . |||. | | ||. . ||| | |||| | |||
gwevynqkkeylrfniyideenssncywkvtsinkeykmcssyssslvvlskaldkdlekifsfrskgripslswkdpssnasisrcsqplvgierarcp
EDEQMLQAIRKANPgSDFVYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCELK------SPSMSDFLWG-LENSGWL
||| .. . | | .|..|.||||||.|| | | |.|| || | |. |. | ||||.|.||.|. . . | .|| .|..||.
edelycsslalsap.sktlylidarpklnaiantangagfenihnypncklvfmnipnihvirksleklvlamkssardkdhtestdmrfwgyieetgwi
RHIKAIMDAGIFIAKAVSeEGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQLM
|||.|..| | |. . | |.||||||||||| |. |.. .||||.|||..|| |||||.|.|||||| | | | |. .| ||...||..|..||.
shiksileaatfsaelil.kgnsilvhcsdgwdrtpqitsltqilldpyyrtivgfqvliekewlsfghkfslrlghlpgneeerspifqqfldccfqll
EQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHSQT
.||| ||| .|. | |.||..| || | .|.| . ... .| |.|. . | .||| . . |.
sqfpllfeftpslllfisdnihsckygtflnncekdrvqdqvktktisiwsevnlnvnkflnpyynpqdiqs
|
|||||||||
subfamily_MTMR3_pd | Subfamily MTMR3 | 129-230 | 7.7e-25 | 80.5 | In-house | 26-129 (442) | alignment | ||
Range on Protein: 129-230
Range on HMM: 26-129/442.0
LIDLSEEYTRMGL-PNHYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQPLSGF-SARCLEDEQMLQAI
.|.||..|.|. .. |..|||| |...| |||..| |||| | . . ...||| .|.|.. . .| | | . |.||| |. . |. |||..|.||
eeklkeeverlGfdlkeawrisdvnsdfklCssyPkklivPksitdddlkkvasfrslkrlPavvwrhkkngavlarcsqPevgwlgWrnaedekllkai
RKAN
||
akac
|
|||||||||
subfamily_pats1_pd | Subfamily pats1 | 133-209 | 7.7e-07 | 19.8 | In-house | 12-90 (691) | alignment | ||
Range on Protein: 133-209
Range on HMM: 12-90/691.0
SEEYTRMGLPNHY-WQLSD-VNRDyrVCDSYPTELYVPKSATAHIIVGSSKFRSrRRFPVLSYYYKDNHAS---ICRSSQPL
|. |..| |. . ..|| ... || |||. . ...| . . || ..||||. ..| .| || ||.
liegqrlkldldkdwrvveflsrd..lseiyPkrilvPklvsdellvsyvrkrs.skiPvlswsnqnnksslfricvynqpf
|
|||||||||
subfamily_MTMR5_pd | Subfamily MTMR5 | 134-208 | 2e-11 | 35.4 | In-house | 12-93 (483) | alignment | ||
Range on Protein: 134-208
Range on HMM: 12-93/483.0
EEYTRMGLPN-------HYWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQP
.|.|.|| . ....| ||..| ||.||| . ||.. . | .| . |.|| . . | | . ||...
qdykRlGlgalngaskrgkfrisevNkkytvcrsYPalivvPsevsddsiarvakcfrqnRlPvvtWrhernkalLiRsggf
|
|||||||||
subfamily_MTMR10_pd | Subfamily MTMR10 | 145-466 | 1.6e-49 | 160.7 | In-house | 25-321 (380) | alignment | ||
Range on Protein: 145-466
Range on HMM: 25-321/380.0
YWQLSDVNRDYRVCDSYPTELYVPKSATAHIIVGSSKFRSRRRFPVLSYYYKDNHASICRSSQpLSGFSARCLEDEQMLQAIRKANPGSdfvyvvdtrpk
. . .| .. ..|. ..||.| . . |. |||.... . . .| . | . || . |.||. .||..|.
aivvllknelfaaaqtlPqyfvvpnslsdsdverlsrhykesRfplwvwshakgaallrlsal.qeaesadkekeekmlelvrkchpan...........
lnamanraagkgyenednysNIKF--QFIGIENIHVMRNSLQKMLEVCELKSPS-----MSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVH
..|. . ...|. . .. .|. |.| . .. .| ||...|| ..... . ..|.| |.. ||..
....................dvklvdlsdelpsiqdvqkaylklreLcvidtseefvtlddkwlssLektrWLayvrlclstasdavktvvekkrsvilq
CSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFG
|.| | |.| |.|.|||||||..|| ||.| |.. ||.| .| |... ..|. |||. | .||.||.|||| .|||.|.||| . . .|. |.
esegrDlscvvaSLaqlmldphyrtisGfqsliqkewvaaghpfldrlghikpseksespvfllFldcvdqlleqfpseFeFtetfLialwdsshsgifl
NFLCNSQKERRELKIQERTYSLWAHLWKN
.||.||...| . . . . . .|.
tflfnseeqrlkavvsssplliakselke
|
|||||||||
subfamily_MTMR3_pd | Subfamily MTMR3 | 236-480 | 9.6e-90 | 294.5 | In-house | 175-420 (442) | alignment | ||
Range on Protein: 236-480
Range on HMM: 175-420/442.0
VYVVDTRPKLNAMANRAAGKGYENEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCElKSPSMSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVL
. .|| | |.|||| | |.|.|. |.| . .|.|. ||| .|.|.... .... .|| |..| ||. ||... .. | . ...||..|| .||
llivdarsytaafanrakgGGceleeyypncevvflglanihavrksfnslralls.qspdesnwlsalektkWlqnlsvllkaavkvveavdkegrpvl
VHCSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDG--DPKEISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYS
||||||||||.|. ..| |||||.||||.|| ||.|..|..|||||. | |. . | .| .|| |....| || .|||..||||| ||. . .| ||
vhCsdGWdrttqivalakllldpyyrtleGfkvlvereWldfGhkfadrcghgenvddanercPvflqwldavhqlqrqfPtsfefneaflvklvqhtys
CQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADHS
| || ||.||.|||.| |..||| |.|. | .. .| | |.. . .
clfGtflansekereeekvkertlsvWsllrakekeyrnllykekte
|
|||||||||
subfamily_MTMR5_pd | Subfamily MTMR5 | 242-456 | 6.9e-56 | 182.0 | In-house | 205-425 (483) | alignment | ||
Range on Protein: 242-456
Range on HMM: 205-425/483.0
RPKLNAMANRAAGKGYEnEDNYSNIKFQFIGIENIHVMRNSLQKMLEVCEL----KSPSMSDFLWGLENSGWLRHIKAIMDAGIFIAKAVSEEGASVLVH
. .| .. ... |... . .|.. | . . .| ...|..|.| .| ...... || .|.| ||. |..... ... . .|.||||
kaaLYvlgeksqlknvk.sevdskaefipvelveirqvkasfkkllraClpstaveeaesqsFlksvedseWlqqissllqlsgavvdlldlqgssvlvs
CSDGWDRTAQVCSVASLLLDPHYRTLKGFMVLIEKDWISFGHKFNHRYGNLDGDPK-EISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQF
|||| |||| |.| |||||.||||.|| ||.||.|..|||.|..| . . ..|| ||..||.|...||| |||||. .| . .| |..|
lEdGwdvtaqvsslaqllldpyYRtleGFkvLveKEWLafGHrFtkrsnqtlsaqssgfaPvFlqFLDcvhqvsrqfPlafefndfylkflayhsvsnrf
GNFLCNSQKERRELKI--QERT
|| .|..|| | . .|..
rtfllDseyerlesgllyeeka
|
|||||||||
0045098 | (Phosphotyrosine protein) phosphatases II | 257-385 | 3.9e-09 | 31.8 | In-house | 125-271 (278) | alignment | ||
Range on Protein: 257-385
Range on HMM: 125-271/278.0
YENEDNYSNIKFQFIGIENIHVMRNSLQkMLEVCELKSPSMSDFLWGLEN--SGWLRHIKAIMDAGIFIAKAVSE------EGASVLVHCSDGWDRTAQV
...|...... .. ..|..|.|..|. ..|. |. ... |. . .. . .|.... | .| ..|. .. .| |||||| |..||. .
llseevlddytlrtllvtnltveredle.srgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtl
CSVASLLLD-----------PHYRTLKGFMVLIEKDWISFGHKFNHRY
. . .| ..|. ...... .... | ..| ..
vaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
|
|||||||||
subfamily_pats1_pd | Subfamily pats1 | 269-384 | 4.2e-21 | 67.0 | In-house | 339-456 (691) | alignment | ||
Range on Protein: 269-384
Range on HMM: 339-456/691.0
QFIGIENIHVMRNSLQKMLE-VCELKSpSMSDFlWGLENSGWLRHIKAIMDAGIFIAKAVsEEGASVLVH-CSDGWDRTAQV---CSVASLLLDPHYRTL
.|. . . ... ..|. . .| . |.... .|.| |. .| ...| . ... . .|| |||.. .|. . . .. |.| .|.||.||||
iflslPtrekveerffdllqsilsldg.sddew.keieeskwvdsvkllleaavkvsnll.deGssvllknsidsPlieldlasisslaqvlsdPfyrtl
KGFMVLIEKDWISFGHKFNHR
||.|||||.|.|.|. |...
dGfkvliekewlsyGfPfski
|
|||||||||
0051429 | (Phosphotyrosine protein) phosphatases II | 286-359 | 2.5e-07 | 26.1 | In-house | 107-178 (272) | alignment | ||
Range on Protein: 286-359
Range on HMM: 107-178/272.0
MLEVCELKSPSMSDFLWGLENSGWLRHIKAImDAGIFIAKAVSEeGASVLVHCSDGWDRTAQVCSVASLLLDPH
.|.. | |.... .. | .|. | . .| . . ... . | |||||| |.|||. |. . |||. .
ellltlllsagearevmhlhytdwpdhgvpq.eallellellld.ggpvlvHCsaGkdRTGtvvallllllgvs
|
|||||||||
PTPc_DSPc_SM00012 | 299-431 | 2.1e-11 | 39.3 | In-house | 38-104 (105) | alignment | |||
Range on Protein: 299-431
Range on HMM: 38-104/105.0
DflwglensgwlrhikaimdagifiakavseeGASVLVHCSDGWDRTAQVCSVASLLLDPHYRTlkgfmvliekdwisfghkfnhrygnldgdpkeispV
. ...|.||||.|..||.... .. || . ...|
s...............................skpvvVhCsaGvgRtgtfvaldillqqleket...................................k
IDQFIECVWQLMEQFPCAFEFNERFLIHIQHHI
... ..|..|..| | .....| .|. .. ..
evdifqivkelrkqRpgmvqteeqylflyrall
|
|||||||||
0049772 | (Phosphotyrosine protein) phosphatases II | 316-356 | 1.1e-06 | 24.2 | In-house | 199-237 (314) | alignment | ||
Range on Protein: 316-356
Range on HMM: 199-237/314.0
IMDAGIFIAKAvsEEGASVLVHCSDGWDRTAQVCSVASLLL
. .. || .| ..| |||||..|..||. . .| |..
fdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmk
|
|||||||||
0044763 | (Phosphotyrosine protein) phosphatases II | 322-351 | 8.3e-07 | 24.3 | In-house | 101-130 (178) | alignment | ||
Range on Protein: 322-351
Range on HMM: 101-130/178.0
FIAKAVSEEGASVLVHCSDGWDRTAQVCSV
|| .|..|.| |||||| |..|.. ..
fieealdekggpvlVHCsaGvgRsgtlvaa
|
|||||||||
0051082 | (Phosphotyrosine protein) phosphatases II | 322-356 | 3.9e-06 | 22.1 | In-house | 83-117 (151) | alignment | ||
Range on Protein: 322-356
Range on HMM: 83-117/151.0
FIAKAVSEEGASVLVHCSDGWDRTAQVCSVASLLL
|. .. . .. |||||| |..||. .. . .||
flellldkkngpvlvHCsaGkgRTGtlvalylmll
|
|||||||||
subfamily_MTMR14_pd | Subfamily MTMR14 | 325-385 | 1e-06 | 19.8 | In-house | 261-328 (357) | alignment | ||
Range on Protein: 325-385
Range on HMM: 261-328/357.0
KAVSEEG-ASVLVHCSDGWDRTAQVCSVA--SLLLDPH-YRTLKGFMV---LIEKDWISFGHKFNHRY
| |.|.. . .|||| ||||| |. || | . ...|. . . || |||.. .|
kyvkededsGllvhcisGWdrtPlfvsllrlslWadglihqslsaaellyltvaydWflfghqlpdrl
|
|||||||||
subfamily_pats1_pd | Subfamily pats1 | 394-479 | 1.3e-23 | 75.3 | In-house | 551-636 (691) | alignment | ||
Range on Protein: 394-479
Range on HMM: 551-636/691.0
EISPVIDQFIECVWQLMEQFPCAFEFNERFLIHIQHHIYSCQFGNFLCNSQKERRELKIQERTYSLWAHLWKNRADYLNPLFRADH
||. ||.. |||| .|| ||||| .|. . .. .| .|||||.. |.. | |. .|. |.|. .|.. ..| |..
sfsPifvqfldlvwqlqkefPfhfefneslllllvkesfssrfGnflyseakrdserkvlkrsksiwsfinqnksrfinllykhsa
|
|||||||||
DUF972 | Protein of unknown function (DUF972) | 506-562 | 5.5e-06 | 13.2 | Pfam-A | 16-66 (107) | alignment | ||
Range on Protein: 506-562
Range on HMM: 16-66/107.0
RFEKGMQPRQSVTDYLMAVKEETQQLEEELEALEERLEKIQKvqlnctKVKSKQSEP
. |. .. ... . | .. || ..|. | |.|.||||.... . |.|...
qleellkeleelkkelaelleenaelkleneklrerleelee......eekkkekkk
|
|||||||||
Mcm10 | Mcm10 replication factor | 507-609 | 4.1e-07 | 15.9 | Pfam-A | 21-123 (344) | alignment | ||
Range on Protein: 507-609
Range on HMM: 21-123/344.0
FEKGMQPRQSVTDYLMAVKEETQQLeEELEALEERLEKIQKVQLNCTKVKSKQSEPSKH-SGFSTSDNSIANTPQDYSGNMKSFPSRSPSQGDEDSALIL
||. || .|.. . ... ..| | |||...| |.||| |. .. ..|.|..| .. .| .. ...|. ... . |.| . | ||
aekagqpkksisasellkqqkkkdl.erlearkkraeeiqkrvLqssekeeksskasssakstlqspkaaselpkarkfsleaaatPklsrgfsesedil
TQDN
|.
ladk
|
|||||||||
DUF342 | Protein of unknown function (DUF342) | 523-576 | 7.5e-06 | 10.8 | Pfam-A | 331-381 (451) | alignment | ||
Range on Protein: 523-576
Range on HMM: 331-381/451.0
AVKEETQQLEEELEALEERLEKIQKVqlnCTKVKSKQSEPSKHSGFSTSDNSIA
..||....||||||.|||.|||..| .|..... |. | .. . ...
elkeklkeleeeleeleeeleklkkk...lkklpklkaegqlesekkeqlekll
|