Gene PALD1 in Homo sapiens

Synonym: KIAA1274, PALD, RP11-710A11.1, PALD1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Paladin
Subfamily Paladin
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP061_AA protein Get Run
HsapP061_AA_54-379 phosphatase_domain Get Run
HsapP061_AA_440-810 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0049772 (Phosphotyrosine protein) phosphatases II 55-333 9.4e-30 99.8 In-house 1-240 (314) alignment 
Range on Protein: 55-333
Range on HMM: 1-240/314.0
KVAPVVITYNckeEFQIHDELLKAHYTLGRLSDNTP-EHYLVQGRYFLVRDVTEKMDVLgtvgscGAPNFRQVqGGLTVFGMGQPSLSGFRRVLQKLQKD
|||.......   |..|||.|||....|.|.|.... |........||.||.   .|.|      .|.|.... .|| |.|..... |... .|. ... 
kvayplasfs...ellihddllklllvlnrrslsvlpeltilvadlflnrdknryldil......padnrvil.pglpvsgsdyinasyvdgflkfIatq

GHRECVIFCVREEPVLFLradeDFVSYTPRDKQNLHEnlqglgpgvrveslelairkeIHD---------------------FAQLSENTyhvyhnteDL
|..|..... ||||||..    .. ....|...|..                      |.                      . .|..|.        ..
gpleitvvdfreepvlyy....ngwrmvlrgdlnvrd.....................ivmsrdevladelsrLdaAlgKtpllildgng........ne

---------WgephavaihgeddlhvtEEVYKRPLFLQPTYRYHRLPLPEQGSPLEAQLDAFVSVLRETpsllQlrdahgPPPALVFSCQMGVGRTnlG-
                           ||.| ..|| .. ..|.|.|.|  . ||....|.|. ...|     .      .. .... |..|.|||  | 
ptaadlellk.................eelydpelferlgikylripvpDgsaplledfdeflefieea....d......kggpvlvHCkaGkgRt..gt

-MVLGTLILLHR
 .|.. |..|..
fvvaaylmkllg
subfamily_Paladin_pd Subfamily Paladin 57-380 6.7e-141 458.7 In-house 1-314 (314) alignment 
Range on Protein: 57-380
Range on HMM: 1-314/314.0
APVVITYNCKEEFQIHDELLKAHYTLGRLSDNTPEHYLVQGRYFLVRDVTEKMDVLGTVGSCGAPNFRQVQGgLTVFGMGQPSLSGFRRVLQKLQ--KDG
.|.............|.||.....||....|..||..||.|.||||.| ....||| || ..|..|||.|.| |.|.||.||| .|..|||..|.  |..
yplalalsfsrwlrahpelyrlpvtlssaedvaPedllvrgkyflveDdlvslDvLstvrevgvaNFRkvpg.lpvyGmaQPsakglervleyLtdakrr

HRECVIFCVREEPVLflraDEDFVSYTPRDKQNLHENLQGLGPGVR-VESLELAIRKEIHDfaqlSENTYHVYHNTEDLWGEPHAVAIHGEDDLHVTEEV
|||.|....|||.||    ..|.|.|.||.|.||.|||.| |. |. .|.||...||||..    |||.|.||...|.|. |..||.|. .......|||
hrevvvvnlReeavl....ecDgvtYspRekknlkenlpgkgvavddleklEiqlrkeilk....seneyevyadveelkeekeavlitrfetvltmeEv

YKRPLFLQPTYRYHRLPLPEQGSPLEAQLDAFVSVLRETPSLLQLRDAhgppPALVFSCQMGVGRTNLGMVLGTLILLHRSGTTSQPEAAPTQAKPLPME
|...|...||..|||.|||||..|||..||....||.|.||||. .|.    |||||||..|.|||...||...|||||..|.....|........|..|
ysqqlratptlsyhriplpeqkapleedldqllevlkevpsllskedg....palvFschsGkgrTttamvvavLillhkkGevgeeelvsvpdakltke

QFQVIQSFLRMVPQGRRMVEEVDRAIT
.|||........|.|||...|||.|..
efqvvmkvvqllpdGrrvkkevdaald
PTPlike_phytase Inositol hexakisphosphate 161-329 2.6e-32 106.5 Pfam-A 1-148 (149) alignment 
Range on Protein: 161-329
Range on HMM: 1-148/149.0
FCVREEPVLflraDEDFVSYTPRDKQNLHENLQGLGP--GVRVESLELAIRKEIHDFAQLSENTYHVYHNTEDLWgEPHAVAIHGeddlhvteEVYKRPL
...|||||.    . ..  ...|......|||. .    . ..| || ........ |.  |... |...||.   . . ... .        |||.. |
inLReEpvv....yingrpfvlreqedelenlkeysgieaeeledlekrlkedvlkeaeeyegrilvhreteegv.qktltevte........evyeeel

FLQPTYRYHRLPLPEQGSPLEAQLDAFVSVLRETPSllqlrdahgpPPALVFSCQMGVGRTNLGMVLGTLI
. .. ..|.|.|.... .| |...||||......|.           .||||.||.| |||...||...|.
aegfgvkYvRipitdeqapeeedvDafvrlikslpr..........dtalvfnCqaGrgRTTtamviadLl
PTPlike_phytase Inositol hexakisphosphate 161-329 2.6e-32 106.5 In-house 1-148 (149) alignment 
Range on Protein: 161-329
Range on HMM: 1-148/149.0
FCVREEPVLflraDEDFVSYTPRDKQNLHENLQGLGP--GVRVESLELAIRKEIHDFAQLSENTYHVYHNTEDLWgEPHAVAIHGeddlhvteEVYKRPL
...|||||.    . ..  ...|......|||. .    . ..| || ........ |.  |... |...||.   . . ... .        |||.. |
inLReEpvv....yingrpfvlreqedelenlkeysgieaeeledlekrlkedvlkeaeeyegrilvhreteegv.qktltevte........evyeeel

FLQPTYRYHRLPLPEQGSPLEAQLDAFVSVLRETPSllqlrdahgpPPALVFSCQMGVGRTNLGMVLGTLI
. .. ..|.|.|.... .| |...||||......|.           .||||.||.| |||...||...|.
aegfgvkYvRipitdeqapeeedvDafvrlikslpr..........dtalvfnCqaGrgRTTtamviadLl
PTPc_DSPc_SM00012 264-379 5.9e-07 25.0 In-house 3-97 (105) alignment 
Range on Protein: 264-379
Range on HMM: 3-97/105.0
YRYHRLPLPEQGSPLEAqlDAFVSVLRETPSLLQLRDAhgpPPALVFSCQMGVGRTNLGMVLGTLILLHRSGTtsqpeaaptqakplpmEQFQVIQSFLR
..|| .  |..| | |.  |.....||.. .  . ..     . .|  |. |||||   ..| .|.  ....|                ..... | . .
khyhytgwpdhgvPees..dsilellravkknknkses...skpvvVhCsaGvgRtgtfvaldillqqleket................kevdifqivke

MVPQGRRMVEEVDRAI
.  | ..||.. .  .
lrkqRpgmvqteeqyl
0049772 (Phosphotyrosine protein) phosphatases II 441-810 8.7e-39 129.5 In-house 3-312 (314) alignment 
Range on Protein: 441-810
Range on HMM: 3-312/314.0
QYPLAfalSFSRWLCaHPELYRLPVTLSSAGPVAPRDLIargSLREDDLVSPDALSTVREMDVANFRRVPRMPIYGTAQPSAKALGSILAYLtdAKRRLR
.||||   |||..|. |..|..| ..|.. .......|.    |  |... .| ... ... . |....|..|..|.....|. . ..|...  |..  .
aypla...sfselli.hddllklllvlnrrslsvlpelt...ilvadlflnrdknryldilpadnrvilpglpvsgsdyinasyvdgflkfI..atqgpl

KVVWVSLREEAVLECDGHTYSLRWPGPPVAPD-----------------------------QletleaqlkahlSEPPPGKEGPLTyrfqtcltmQEVFS
....|..||| ||...|....||.   .  .                              .            .||..     |          .|...
eitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng............neptaadlellk.........eelyd

QHRRACPGLTYHRIPMPDFCAPREEDFDQLLEALRAAlskDPGTGFVFSCLSGQGRTTTAMVVAVLafwhiqgfpevgeeelvsvpdakftkgefqvvmk
...   .|..|.|||.||..|| .||||..||....|   |.|. ... | .| |||.|..|.| |                                  
pelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaayl..................................

vvqllpdghrvkkevdaaldtvsetMTPMHYHLREIiICTYRQAKAAKEAQEMRRLQLRSLQY----LERYVCLILFNAYLHLEKADSWQRPFSTWMQEV
                         |  ... |.|. .  .|..  ..  . ... ... ...    ||..  |. |. ||.....|..|...|....|.
.........................mkllgvsleea.ledvrlkRpinpnpgfieqleqyefilealleylkflkkfyeyleenlldglqllisellkel

ASK
|.|
alk
subfamily_Paladin_pd Subfamily Paladin 442-731 1.6e-143 467.4 In-house 1-314 (314) alignment 
Range on Protein: 442-731
Range on HMM: 1-314/314.0
YPLAFALSFSRWLCAHPELYRLPVTLSSAGPVAPRDLIARGS--LREDDLVSPDALSTVREMDVANFRRVPRMPIYGTAQPSAKALGSILAYLTDAKRRL
||||.||||||||.|||||||||||||||..|||.||..||.  |.||||||.|.||||||..|||||.||..|.||.||||||.|...|.||||||||.
yplalalsfsrwlrahpelyrlpvtlssaedvaPedllvrgkyflveDdlvslDvLstvrevgvaNFRkvpglpvyGmaQPsakglervleyLtdakrrh

RKVVWVSLREEAVLECDGHTYSLR--------WPGPPVAPDQLETLEAQL-------------KAHLSEPPPGKEGPLTYRFQTCLTMQEVFSQHRRACP
|.||.|.|||||||||||.|||.|        .||..||.|.||.||.||             .|...|....||..|..||.|.|||.||.||..||.|
revvvvnlReeavlecDgvtYspRekknlkenlpgkgvavddleklEiqlrkeilkseneyevyadveelkeekeavlitrfetvltmeEvysqqlratp

GLTYHRIPMPDFCAPREEDFDQLLEALR---AALSKDPGTGFVFSCLSGQGRTTTAMVVAVLAFWHIQGfpEVGEEELVSVPDAKFTKGEFQVVMKVVQL
.|.|||||.|...||.|||.|||||.|.   ..|||..|...||||.||.||||||||||||...|..|  ||||||||||||||.||.|||||||||||
tlsyhriplpeqkapleedldqllevlkevpsllskedgpalvFschsGkgrTttamvvavLillhkkG..evgeeelvsvpdakltkeefqvvmkvvql

LPDGHRVKKEVDAALD
||||.|||||||||||
lpdGrrvkkevdaald
0051082 (Phosphotyrosine protein) phosphatases II 503-674 1.1e-06 23.8 In-house 5-112 (151) alignment 
Range on Protein: 503-674
Range on HMM: 5-112/151.0
VANFRRVPRMpIYGTAQPSAkalgSILAYLtdAKRRLRKVVWVSLREEAVlecdghTYSLRWP--Gppvapdqletleaqlkahlsepppgkegpltyrf
. ||..|    .| ...|.|      |..|  ..  .. .| .   ||        ..  ..|  |                                  
yinfsyvtgg.lyrsggpla....dflell..kelgiktivnlrseeerg......ycpeylpelg..................................

qtcltmqevfsqhrracpgLTYHRIPMPDFCAPREED-FDQLLEALRAALSkDPGTGFVFSCLSGQGRTTTAMVV
                   .....||..|...|  .. ||..||.|...|. ...  ... | .| ||| | ...
...................ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlval
PTPlike_phytase Inositol hexakisphosphate 545-677 4.1e-27 89.6 Pfam-A 1-147 (149) alignment 
Range on Protein: 545-677
Range on HMM: 1-147/149.0
VSLREEAVLECDGHTYSLRWPGPPV---------APDQLETLEAQLKAHLSEPPPGKEGPLTY-RFQTCL---TMQEV----FSQHRRACPGLTYHRIPM
..||||.|....|....|| .  .          ....|| ||..||... .     || . . | ..     |..||    ....    .|..|.|||.
inLReEpvvyingrpfvlreqedelenlkeysgieaeeledlekrlkedvlkeaeeyegrilvhreteegvqktltevteevyeeelaegfgvkYvRipi

PDFCAPREEDFDQLLEALRAAlSKdpGTGFVFSCLSGQGRTTTAMVVAVL
.| .||.|||.|....... . ..   | .||.|  |.||||||||.| |
tdeqapeeedvDafvrliksl.pr..dtalvfnCqaGrgRTTtamviadL
PTPlike_phytase Inositol hexakisphosphate 545-677 4.1e-27 89.6 In-house 1-147 (149) alignment 
Range on Protein: 545-677
Range on HMM: 1-147/149.0
VSLREEAVLECDGHTYSLRWPGPPV---------APDQLETLEAQLKAHLSEPPPGKEGPLTY-RFQTCL---TMQEV----FSQHRRACPGLTYHRIPM
..||||.|....|....|| .  .          ....|| ||..||... .     || . . | ..     |..||    ....    .|..|.|||.
inLReEpvvyingrpfvlreqedelenlkeysgieaeeledlekrlkedvlkeaeeyegrilvhreteegvqktltevteevyeeelaegfgvkYvRipi

PDFCAPREEDFDQLLEALRAAlSKdpGTGFVFSCLSGQGRTTTAMVVAVL
.| .||.|||.|....... . ..   | .||.|  |.||||||||.| |
tdeqapeeedvDafvrliksl.pr..dtalvfnCqaGrgRTTtamviadL
0048179 (Phosphotyrosine protein) phosphatases II 603-676 3e-09 32.3 In-house 33-105 (144) alignment 
Range on Protein: 603-676
Range on HMM: 33-105/144.0
CLTMQEVFSQHRRACPGLTYHRIPMPDFCAPRE-EDFDQLLEALRAALSkdPGTGFVFSCLSGQGRTTTAMVVAV
 ....| . ..   ..|..|...|.||...|   |.....||....||.  .|   .  |  | |||.| ..  .
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaayl
0044763 (Phosphotyrosine protein) phosphatases II 604-677 1.1e-07 27.1 In-house 75-133 (178) alignment 
Range on Protein: 604-677
Range on HMM: 75-133/178.0
LtmqevfsqhrracpgLTYHRIPMPDFCAPR-EEDFDQLLEALRAALSKDPGTGFVfSCLSGQGRTTTAMVVAVL
                ..|..||.||...|   | |....|....||....|. .|  |  | ||..| ..   .
g...............iqylhipipDhgvpdllehflefvefieealdekggpvlV.HCsaGvgRsgtlvaaylm
0040438 (Phosphotyrosine protein) phosphatases II 607-677 2.1e-06 22.7 In-house 149-232 (317) alignment 
Range on Protein: 607-677
Range on HMM: 149-232/317.0
QEVFsqhrraCPGLTYHRIPM-------------------PDFCAP-REEDFDQLLEALRAALSkDPGTGFVFSCLSGQGRTTTAMVVAVL
.|.       ..| |......                   ||...|   ... ..|||.|.||. |||.  .  |  | ||| |  .. ..
seee......lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylm
subfamily_DSP23_pd Subfamily DSP23 608-673 8.1e-09 30.3 In-house 40-103 (148) alignment 
Range on Protein: 608-673
Range on HMM: 40-103/148.0
EVFSQHRRACPGLTYHRIPMPDFCAPREEDFDQLLEALRAALSKDPGTGfvFSCLSGQGRTTTAMV
|    |  |.|.||..|. ..|.. |  |. ..... .  | .|.   .    || |.||| | . 
eegrphveatpnltlvrlriddyhppaleqvvefvrvveeaeekneavs..vhcllgrgrtgtmla
0042113 (Phosphotyrosine protein) phosphatases II 612-677 2.1e-09 32.6 In-house 133-199 (245) alignment 
Range on Protein: 612-677
Range on HMM: 133-199/245.0
QHRRACPGLTYHRIPMPDFCAPR-EEDFDQLLEALRAALSKDPGTGFVFSCLSGQGRTTTAMVVAVL
..     ...||..|.||...|   |.....||..| ||..|...  .. |  | ||| | ...  .
gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm
0036282 (Phosphotyrosine protein) phosphatases II 614-677 3.9e-08 28.7 In-house 64-127 (174) alignment 
Range on Protein: 614-677
Range on HMM: 64-127/174.0
RRACPGLTYHRIPMPDFCAPREEDFDQLLEALRAALSKDPGTGFVFSCLSGQGRTTTAMVVAVL
     |..|...|.||...|  . ......... |||.|||   .  |  | ||| | ..   .
dlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylm
0037934 (Phosphotyrosine protein) phosphatases II 614-677 9.1e-08 27.4 In-house 130-201 (243) alignment 
Range on Protein: 614-677
Range on HMM: 130-201/243.0
RRACPGLTYHRIPMPDFCAPR-EEDFDQLLEALRAALSK-------DPGTGFVFSCLSGQGRTTTAMVVAVL
   . .  ||..|.||...|   ||. ..|...|. ...       |.|   .  |  | ||| |  .  ..
dltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylm
0051429 (Phosphotyrosine protein) phosphatases II 614-678 2.8e-07 26.0 In-house 64-174 (272) alignment 
Range on Protein: 614-678
Range on HMM: 64-174/272.0
RRACPGLTYHRIPMPDFCAPREEDF-------------------------------------------------DQLLEALRAALSkdpGTGFVFSCLSG
 |  ||..|...|..|..||. . .                                                 ..|||.|.. |.   |  ... | .|
drywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld...ggpvlvHCsaG

QGRTTTAMVVAVLA
 .|| |. ..  |.
kdRTGtvvalllll
0043336 (Phosphotyrosine protein) phosphatases II 614-677 1.6e-06 23.2 In-house 170-233 (278) alignment 
Range on Protein: 614-677
Range on HMM: 170-233/278.0
RRACPGLTYHRIPMPDFCAP-REEDFDQLLEALRAALSkDPGTGFVFSCLSGQGRTTTAMVVAVL
   . .. || ...||...|   ... ..|.|.| ||. |...  .. |  | ||| | ... .|
gesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyll
0043147 (Phosphotyrosine protein) phosphatases II 616-675 4.8e-07 25.2 In-house 62-121 (172) alignment 
Range on Protein: 616-675
Range on HMM: 62-121/172.0
ACPGLTYHRIPMPDFCAPREEDFDQLLEALRAALSKDPGTGFVFSCLSGQGRTTTAMVVA
   |..|...|.||...|  | ....|| .. .| ..||   .  |  | ||| |  .  
erlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaay
0041856 (Phosphotyrosine protein) phosphatases II 616-676 3.1e-06 22.4 In-house 76-131 (182) alignment 
Range on Protein: 616-676
Range on HMM: 76-131/182.0
ACPGLTYHRIPMPDFCAPReedFDQLLEALRAALSkdPGTGFVFSCLSGQGRTTTAMVVAV
 . |..|...|.||...|    .|.||. ....|.  .|   .  |  | ||| |  .  .
erlgiqylylpwpDhgvpd...ldelldfieevle..eggpvlVHCsaGvgRtgtlvaayl
0048076 (Phosphotyrosine protein) phosphatases II 617-676 4.4e-09 31.7 In-house 45-103 (145) alignment 
Range on Protein: 617-676
Range on HMM: 45-103/145.0
CPGLTYHRIPMPDFCAPRE-EDFDQLLEALRAALSKDpgTGFVFSCLSGQGRTTTAMVVAV
  |..|...|.||...|   |.....||....||...     .. |  | |||.| ..  .
rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaayl
0045098 (Phosphotyrosine protein) phosphatases II 617-682 8.3e-06 20.9 In-house 153-233 (278) alignment 
Range on Protein: 617-682
Range on HMM: 153-233/278.0
CPGLTYHRI-PMPDFCAPREE---DFDQLLEALRAALS------------KDPGTGFVFSCLSGQGRTTTAmVVAVLAFWHI
. |.|.. . |.||...| ..    |..||| .|.||.             |.|.  .  |  | ||| |  |.| |   ..
srgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtl.vaaylmlell
0046846 (Phosphotyrosine protein) phosphatases II 618-676 5.2e-08 28.4 In-house 75-131 (176) alignment 
Range on Protein: 618-676
Range on HMM: 75-131/176.0
PGLTYHRIPMPDFCAPREEDFDQLLEALRAALSKDpgTGFVFSCLSGQGRTTTAMVVAV
.|..|...|.||...|  |....|||..| ||...     .  |  | ||| |  .   
lgiqylhlpwpDhgvpdlelllellefirealkeg..gpvlVHCsaGigRtgtlvaayl
0039614 (Phosphotyrosine protein) phosphatases II 619-677 4.6e-06 21.8 In-house 168-245 (297) alignment 
Range on Protein: 619-677
Range on HMM: 168-245/297.0
GLT-----------------YHRIPMPDFCAP-REEDFDQLLEALRAALSKD-PGTGFVFSCLSGQGRTTTAMVVAVL
| |                 .. ...||...|   |.....||..| ||... .|.  .  |  | ||| |  .   .
gytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylm