Gene DNAJC6 in Homo sapiens

Synonym: DJC6, PARK19, DNAJC6

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Auxilin
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP062_AA protein Get Run
HsapP062_AA_104-280 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0040439 (Phosphotyrosine protein) phosphatases II 105-271 5.3e-13 44.6 In-house 24-240 (249) alignment 
Range on Protein: 105-271
Range on HMM: 24-240/249.0
TSSRVIQSVTSYTKGD-------LDFTYVTSRIIVMSFPLDNVDIGFRNQVDDIR-----------------------------------SFLDSRHLDH
 .|||. |...   ..       .|..|.. |.|....||..    |.... . .                                    .|.  ..|.
dhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkdd

YTVYNLSPKS-YRTAKFHSRVSEC-SWPIRQAP-SLHNLFAVCRNMYNWLLQN-PKNVCVVHCLDGRAASSILVGAMFIF----CNLYSTPGPAIRLLYA
|||..|  .  |   ... ..  . .||  ..| |.  |.. .. . ..| .. ......||| .|   . ....|  ..     .|  ..  |..||  
ytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrs

KRPGIGLSPSHRRYLGY
.|||.  .|.. |.| .
qRpgavqnpeqyrflye
0043336 (Phosphotyrosine protein) phosphatases II 106-271 3.1e-14 48.6 In-house 59-271 (278) alignment 
Range on Protein: 106-271
Range on HMM: 59-271/278.0
SSRVIQSVtsyTKGDLDFTYV----------TSRIIVMSFPLDNVDIGFRNQVDDIR----------------------------------SFLDSRHLD
.|||. |.   ..|||| .|.          . ..|....||..    |.. | . .                                   .|.  |||
hsrvklsl...lggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehld

HYTVYNLSPK--SYRTAKFHSRVSECSWPIRQAP-SLHNLFAVCRNMYNWLLqNPKNVCVVHCLDGRAASSILVGAMFIF----CNLYSTPGPAIRLLYA
.|||..|  .   .   ... ..   .||  ..| ||  |.  .. . ..|  ..... .||| .|   .  ....  ..     ..  ..  |.. |  
dytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelre

KRPGIGLSPSHRRYLGY
.|||.  .||. |.| .
qRpgavqtpsqyrflye
0046845 (Phosphotyrosine protein) phosphatases II 106-272 1.4e-12 43.0 In-house 42-269 (284) alignment 
Range on Protein: 106-272
Range on HMM: 42-269/284.0
SSRVIQSVTSY------------TKG-DLDFTYVTSRIIVMSFPLDN-----------------------------VDIGFRNQVDDIRSF-------LD
.|||. ....              .| |||.||.. ..|....||.|                                 .... ..   .       |.
hsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtlls

SRHLDHYTVYNLSPKS---YRTAKFHSRVSECSWPIRQAP-SLHNLFAVCRNMYNWLLQ-NPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTP------
  . |.|||..|. .        ...      ||| ...| |. .|.. .| . ..| . ..... |||| .|   .  .. .. ... |  .       
eevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvd

-GPAIRLLYAKRPGIGLSPSHRRYLGYM
   |.. |  .|||   .... |.. ..
vleavkrlreqRpgmvqtleqyrfvyea
PTEN_1 107-278 5.9e-39 128.9 In-house 6-194 (196) alignment 
Range on Protein: 107-278
Range on HMM: 6-194/196.0
SRVIQSVTSYTKGDLDFTYVTSRIIVMS-FPLDN-----VDIGFRNQVDDIRSFLDSRHLDH-YTVYNLSPKS------YRTAK-FHSRVS--ECSWPIR
 |. ..  .... .||.||.|||||.|. .| ..      .  .|....|....||... |. ..|.|||...      |.  . |.|.|.  .....  
krsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDh

QAPSLHNLFAVCRNMYNWLLQNP-KNVCVVHCLDGRAASSILVGAMFIFCNLySTPGPAIRLLYAKR-PGIGLSPSHRRYLGYMCDLLAD
.||||. ||..|... .|||..| .||..|||  |.  |  .| |  ....  .|.  |..|...|| ||   |||..|.| |  .||| 
gapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapnspsqerlleyfaellae
0037934 (Phosphotyrosine protein) phosphatases II 107-272 4.4e-15 51.4 In-house 25-237 (243) alignment 
Range on Protein: 107-272
Range on HMM: 25-237/243.0
SRVIQsvTSYTKGDLDFTYVTSRIIVMSFPLDN----VDIGFRNQVDDIR---------------------------------SFLDSRHLDHYTVYNLS
|||.    .    .....||| |.|....||..    ..  | . . . .                                  .|...|||.|||..|.
srvkl..egsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtll

PKS---YRTAKFHSRVSECSWPIRQAPS-LHNLFAVCRNMYNWLLQ-------NPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAIRLLYAKRPG
 .    .   ... ..   .||  ..|.   .| . .. ..... .       .......|||  |.  .  |. |  .  .|  ..  |..|| ..|||
lenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpg

-IGLSPSHRRYLGYM
 .  .||..|.| ..
kavqtpsqyrflyea
subfamily_VSP_pd Subfamily VSP 110-272 3.7e-29 96.2 In-house 21-194 (212) alignment 
Range on Protein: 110-272
Range on HMM: 21-194/212.0
IQSVTSYTKG--DLDFTYVTSRIIVMSFPLDNVDIGFRNQVDDIRSFLDSRHLDHYTVYNL-SPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMY
 .    ||.   |||.|||| ||| ||||    .  .|| ....  ||| .| ||| |.|| | ..|  . |. ||...     . |.|..|. ..... 
senkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevk

NWLLQNPKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAIRLLYAKRPGIGL--------SPSHRRYLGYM
.|| ...||| ..||  |.  .  .| |...  ....|   ..  .  .|   .         .|| .||.||.
ewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyl
subfamily_Auxilin_pd Subfamily Auxilin 113-278 2.7e-84 273.9 In-house 1-166 (166) alignment 
Range on Protein: 113-278
Range on HMM: 1-166/166.0
VTSYTKGDLDFTYVTSRIIVMSFPLDNVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQN
|.||.|.|||..|.||||||||||...|.....|..||.||||.||| ..|.|||||...|||||..|||.|..||.|.||.|..|..||||.|.|| ..
vasyakndlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkd

PKNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAIRLLYAKRPGIGLSPSHRRYLGYMCDLLAD
||||.|||| ||||||..||.|...||.|.|.|  |.||...|| .||||||..||| |..||||.
pknvvvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpiglspsekryleyladllae
subfamily_PTEN_pd Subfamily PTEN 116-277 4.3e-36 119.6 In-house 15-180 (184) alignment 
Range on Protein: 116-277
Range on HMM: 15-180/184.0
YTKGDLDFTYVTSRIIVMSFPLDNVDIGFRNQVDDIRSFLDSRHLDHYTVYNL-SPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPK
. . ||| .|.|..||.|..| ....  .||...|.  ||...| ||| .||| | ..| ..||..||...     ..|.|. | ...... .|| ...|
edgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkk

NVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAIRLLYAKRPGI--GL-SPSHRRYLGYMCDLLA
|| ||||  |.  . .|. | .. ..|....  |..|  ..|     |.  || |||. |. .|| 
nvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklle
0039614 (Phosphotyrosine protein) phosphatases II 116-272 1.6e-16 56.1 In-house 78-284 (297) alignment 
Range on Protein: 116-272
Range on HMM: 78-284/297.0
YTKGDLDFTYV-----------TSRIIVMSFPLDNVDIGFRNQVDDIR---------------------------------SFLDSRHLDHYTVYNLSPK
. . ||| .|.           | ..|....||..    | . | . .                                  .|.  |||.|||..|. .
edgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevt

SYRTAKFHSRVSECSWPIRQAP-SLHNLFAVCRNMYNWLLQN-PKNVCVVHCLDGRAASSILVGAMFIF----CNLYSTPGPAIRLLYAKRPGIGLSPSH
 .   ... ..   .||  ..| ||  |. ... . ..| .. ......||| .|   .  ...|  ..    ..   ..  |.. |  .|||.  .||.
nngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsq

RRYLGYM
 |.| ..
yrflyda
0042113 (Phosphotyrosine protein) phosphatases II 116-271 2.1e-13 45.7 In-house 30-237 (245) alignment 
Range on Protein: 116-271
Range on HMM: 30-237/245.0
YTKGDLDFTYV----------TSRIIVMSFPLDNvdigfrnqvdDIR---------------------------------------------SFLDSRHL
 ..|||| .|.          | ..|....||..          ..                                               .|.  ||
pdggdldsdyinasyvdgyritpkfiatqgPlpe..........tvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehl

DHYTVYNLSPK--SYRTAKFHSRVSECSWPIRQAPS-LHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIF----CNLYSTPGPAIRLLY
|.|||..|. .   .   ... ..   .||  ..|. |  |. ... . ..| ........||| .|.  .  ...|  ..     .|  ..  |.. | 
ddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelr

AKRPGIGLSPSHRRYLGY
 .|||.  .||. |.| .
sqRpgavqtpsqyrflye
0040438 (Phosphotyrosine protein) phosphatases II 116-273 2.4e-11 38.9 In-house 64-272 (317) alignment 
Range on Protein: 116-273
Range on HMM: 64-272/317.0
YTKGDLDFTYV----------TSRIIVMSFPLDNVDIGFRNQVDD-----IRSF------------------------------LDSRHLDHYTVYNLSP
 ..|||| .|.          . ..|....||.|    | . | .     | ..                              |.  .|...|...|  
plggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlev

KS-YRTAKFHS-RVSECSWPIRQAP-SLHNLFAVCRNMYNWLLqNPKNVCVVHCLDGRAASSILVGAMFIF----CNLYSTPGPAIRLLYAKRPGIGLSP
.  .   ...       .||   .| |.  |.. .. . ..|  .|.....||| .|   .  ...|  ..     .   ..  |.. | ..|||.  .|
edlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtp

SHRRYLGYMC
.. |.| .. 
eqyrflydal
subfamily_Tensin_pd Subfamily Tensin 118-279 8.5e-39 126.0 In-house 8-174 (189) alignment 
Range on Protein: 118-279
Range on HMM: 8-174/189.0
KGDLDFTYVTSRIIVMSFPLDNVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVC
| ||| ||.|.|||..||| . ..  .|... |.  .|.|.| |.| |.||| |.|   |....| .  ||  .||||  | ..|... .|| ..|.|| 
kvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqnvv

VVHCLDGRAASSILVGAMFIFCNLYSTPGPAI-----RLLYAKRPGIGLSPSHRRYLGYMCDLLADK
||||  |.   ...| |   . .. ..   |.     . .. ..    . ||.|||. |. .||..|
vvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgk
0046846 (Phosphotyrosine protein) phosphatases II 118-276 9.1e-17 56.8 In-house 7-172 (176) alignment 
Range on Protein: 118-276
Range on HMM: 7-172/176.0
KGDLDFTYVTSRIIVMSFP-----------LDNVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPKsyrTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMY
  |||..|.. ..|..|.|            |...  ...... . .... ..|... ..|. |      |.. ..  . ||  ..|.|  |. ... ..
gldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgiqylhlpwpDhgvpdlelllellefir

NWLLQNpkNVCVVHCLDGRAASSILVGAMFIFCNLYSTPGPAIRLLYAKRP-GIGLSPSHRRYLGYMCDLL
..| ..  .. .|||  |.  .  || |  . ..   ..  |..|. ..|| |.  .|...|.| ..  ||
ealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
0051082 (Phosphotyrosine protein) phosphatases II 119-267 1.7e-14 49.2 In-house 4-143 (151) alignment 
Range on Protein: 119-267
Range on HMM: 4-143/151.0
GDLDFTYVTSRIIVMSFPLDnvdigfrnqvdDIRSFLdsRHLDHYTVYNLSPKS---YRTAKFHS---RVSECSWPIRQAPSLHNLFAVCRNMYNWLLQN
. ..|.|||........||.           |   .|  ..|...|..|| ..    | .  ...   .|  . ..  ..|.|  .|. .... ..||..
dyinfsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldk

PKNVCVVHCLDGRAASSILVGAMFIFCNlySTPGPAIRLLYAKRPGIGLSPSHRR
......|||  |.  . .||... . ..   ..  |.. . .||||.  .. ...
kngpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrpgvvqpnqqfl
0036282 (Phosphotyrosine protein) phosphatases II 120-276 9e-28 92.5 In-house 9-169 (174) alignment 
Range on Protein: 120-276
Range on HMM: 9-169/174.0
DLDFTYVTSRIIVMSFPLDNVDIGFRNQVDDIRSFLDSRHLDHYTVYNLSPK-SYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCV
.||..|.|.|.|....||....  ..... .. ..|....|..| ..|. |  ..   ... ..  . || ...|.|. |. ... ....|...|.....
pldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvl

VHCLDGRAASSILVGAMFIFCNLYSTPGPAIRLLYAKR---PGIGLSPSHRRYLGYMCDLL
|||  |.  . .||.|. . ..|....  |..|....|   ||.  .||..|.| |...||
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekll
0043147 (Phosphotyrosine protein) phosphatases II 120-271 1.9e-15 52.5 In-house 12-155 (172) alignment 
Range on Protein: 120-271
Range on HMM: 12-155/172.0
DLDFTYVTSRIIVMSFPldnvdigFRNQVDDIRSFLDSRHLDHytVYNLSPK---SYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNV
.||..|.. |.|.. .|       .|| ..| . .| ... .|  ..|| .     .   ..  ..  ..||   .|.|  |  ... ....|...|...
yldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggp

CVVHCLDGRAASSILVGAMFIFCNLysTPGPAIRLLYAKRPGIGLSPSHRRYLGY
..|||  |   .  || |  . ..|  ..  |..|. .||||.  .||..|.| |
vlVHCsaGvgRtgtlvaaylmllgl..sleeavalvrekRpgavqnpsqyrflyy
0041856 (Phosphotyrosine protein) phosphatases II 120-271 3.6e-12 41.7 In-house 16-165 (182) alignment 
Range on Protein: 120-271
Range on HMM: 16-165/182.0
DLDFTYVTSRIIVMSFPLDNVDIGFRNQVDDIRSFLDSRHLDHY-TVYNLSPKSYRTAKFHS---RVSECSWPIRQAPSLHNLFAVCRNMYNwllqnPKN
..|..|.. .....|.| ..  .  ..  ... .||.  .  .. |. ||..  |   ...    ..   .||   .|.|. |.. .. ...     ...
srdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....egg

VCVVHCLDGRAASSILVGAMFIFCNlYSTPGPAIRLLYAKRPGIGLSPSHRRYLGY
...|||  |.  .  ||.| .. ..   ..  |..|.  .|||.  .|.. ..| .
pvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrRpgmvitpnqyfflql
0044763 (Phosphotyrosine protein) phosphatases II 120-273 1.1e-08 30.5 In-house 20-167 (178) alignment 
Range on Protein: 120-273
Range on HMM: 20-167/178.0
DLDFTYVTSRIIVMSFPLdnvdigfrnqvDDIRSFLDSRHLDHytVYNLSP---------KSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLL
 ....... .....|.|             | . .|   ...|  . ||..           |   ... ..  . .|   .|.|   |  . .. . .|
yinaseilpglylgslpp...........addlellkelgith..ivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeal

QNPKNVCVVHCLDGRAASSILVGAMFIFCNLYsTPGPAIRLLYAKRPgIGLSPSHRRYLGYMC
........|||  |.  |  || |  . .. . ..  ||.|. ..|| |  .|...|.| .. 
dekggpvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerRp.ivpnpgqlrqLyefe
0045450 (Phosphotyrosine protein) phosphatases II 124-271 1.5e-10 36.8 In-house 142-298 (307) alignment 
Range on Protein: 124-271
Range on HMM: 142-298/307.0
TYVTSRIIVMSFPLDNVDIGFRNqvdDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSEC---SWPIRQAP-SLHNLFAVCRNMYNWLLQN-PKNVCV
.. ....... .|...  . ..|   .   .|.  |||.|||..|  . ..  ... .|      .||  ..| |.  |.. .. . ..| .. ......
velgrekcaqywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvl

VHCLDGRAASSILVGAMFIFCNLY-------STPGPAIRLLYAKRPGIGLSPSHRRYLGY
||| .|   .  ...|  . ..|         ..  |..|| ..|||.  .|.. |.| .
VHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflye
0038934 (Phosphotyrosine protein) phosphatases II 125-280 1e-18 63.2 In-house 15-180 (194) alignment 
Range on Protein: 125-280
Range on HMM: 15-180/194.0
YVTSRIIVMSFPLDN-----VDIGFRNQVDDIRSFLDSRHLDHYTVYNLS--PKSYRTAKFHSR-VSECSWPI---RQAPSLHNLFAVCRNMYNWLLQNP
..| |.|....||..     ..   |. ..|. ..|.... ....|..|.   . | . .|... .   ..|.     .||| .|.  .. .. .| ..|
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

KNVCVVHCLDGRAASSILVGAMFIFCNLYsTPGPAIRLLYAKRPGIGLSPSHRRYLGYMCDLLADKP
..|..|||  |.  . .||.|  | .. . ..  ||.|.  ||||.  ...  ..|    . | ...
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekRpgaipnqdyleallkrykelrkav
0049772 (Phosphotyrosine protein) phosphatases II 127-267 1.7e-07 26.8 In-house 120-264 (314) alignment 
Range on Protein: 127-267
Range on HMM: 120-264/314.0
TSRIIVM---------------------SFPLDNVDigfrnqvddirSFLDSRHLDHYTvynlsPKSYRTAKFHSRVSEC---SWPIRQAPSLHNLFAVC
 .|.|||                       .||              .... ..|...      .  |   .|  .. .     .|  .||.|  . ...
nvrdivmsrdevladelsrLdaAlgKtpllildgng...........neptaadlellk.....eelydpelferlgikylripvpDgsaplledfdefl

RNMYNWllqNPKNVCVVHCLDGRAASSI-LVGAMFIFCNLYsTPGPAIRLLYAKRPgIGLSPSHRR
. . ..   ..... .||| .|.  .   .| |. . .. . ..  |.. . .||| |. .|. ..
efieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrlkRp.inpnpgfie
0049260 (Phosphotyrosine protein) phosphatases II 144-271 5.8e-12 41.0 In-house 18-144 (152) alignment 
Range on Protein: 144-271
Range on HMM: 18-144/152.0
FRNQVDDIRSFLDSRHLDHYTVYN-LSPKSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCVVHCLDGRAASSILVGAMFIFcnLY
 .| ..|   .| . . ... ... |... .   ... ..  . ||   .|.|. |.  .  . ..|.........|||  |   .  || |  .   | 
gpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml..lg

STPGPAIRLLYAKRPGIGLSPSHRRYLGY
 ..  |..|. .||||.  .|...|.| .
vsleeavalvrekRpgavpnpgqlrflye
0048076 (Phosphotyrosine protein) phosphatases II 144-272 3.6e-11 38.4 In-house 12-138 (145) alignment 
Range on Protein: 144-272
Range on HMM: 12-138/145.0
FRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHSRVSECSWPIRQAPSL-HNLFAVCRNMYNWLLQNpkNVCVVHCLDGRAASSILVGAMFIFCnLY
... . . ...   ..|...||.||..  .   ... ..  ..|| ...|.|   | .... . ..| ..  ....|||  |.  .  ||.|. ... | 
ylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaaylmll.lg

STPGPAIRLLYAKRPGIGLSPSHRRYLGYM
 ..  |..|. ..|||.  .|...|.| . 
vsleealelvrsqrpgavpnpgqlrflyef
0048179 (Phosphotyrosine protein) phosphatases II 144-271 1.1e-10 37.0 In-house 12-139 (144) alignment 
Range on Protein: 144-271
Range on HMM: 12-139/144.0
FRNQVDDIRSFLDSRHLDHYTVYNLSPKSYRTAKFHS--RVSECSWPIRQAPSL-HNLFAVCRNMYNWLLQNpkNVCVVHCLDGRAASSILVGAMFIFCN
... . . ...   ..|...||.||... . .   .   ..  ..|| ...|.| . | .... . ..| ..  ....|||  |.  .  || |  ....
ylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtlvaaylmkkl

LySTPGPAIRLLYAKRPGIGLSPSHRRYLGY
   ..  |..|. ..|||.  .|...|.| .
g.lsleealalvrsrrpgavpnpgqlrfLle
0045098 (Phosphotyrosine protein) phosphatases II 150-271 8.3e-10 34.0 In-house 127-266 (278) alignment 
Range on Protein: 150-271
Range on HMM: 127-266/278.0
DIRSFlDSRHLDHYTVYNLSPKSYRTAKFHSRVSEC-SWPIRQAPSLH---NLFAVCRNMYNWLL------------QNPKNVCVVHCLDGRAASSILVG
..  . |  .| ...|.||. . .   ... ..  . .||   .|||.    .. ... . ..|             ........|||  |   .  ||.
seevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlva

AMFIFCNL--YSTPGPAIRLLYAKRPG-IGLSPSHRRYLGY
|. . ..|    ..  |.. |  .||| .  .... |.| .
aylmlelleggvdlleavkelrsqRpglavqnleqyrflye
0047943 (Phosphotyrosine protein) phosphatases II 154-270 6.6e-10 34.4 In-house 141-265 (273) alignment 
Range on Protein: 154-270
Range on HMM: 141-265/273.0
FLDSRHLDHYTVYNLSPKS--YRTAKFHSRVSECSWPIRQAP-SLHNLFAVCRNMYNWLLQN-PKNVCVVHCLDGRAASSILVGAMFIF----CNLYSTP
.|.  . |.|||..|  ..  .   ..   .   .||  ..| ||  |.  .. . ..| ..  ... |||| .|   .  .. .  ..    ..   ..
llseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdv

GPAIRLLYAKRPGIGLSPSHRRYLG
  |..||  .|||.  .|...|.| 
leavkllrsqRpgmvqtpeqyrfly
0051299 (Phosphotyrosine protein) phosphatases II 154-269 3.2e-09 32.1 In-house 153-278 (288) alignment 
Range on Protein: 154-269
Range on HMM: 153-278/288.0
FLDSRHLDHYTVYNLSPK------SYRTAKFHSRVSECSWPIRQAPS-LHNLFAVCRNMYNWLLqNPKNVCVVHCLDGRAASSILVGAMFIFC----NLY
.|.  .||.|||..|  .         . ..       .||  ..|. .  |.. .| ....|  ......|||| .|   .  .. .  ...    .  
llseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekegg

STPGPAIRLLYAKRPGIGLSPSHRRYL
 ..  |.. |  .|||.  .|.. |..
vdvleavkrlreqRpgmvqtpeqyrfv
0050432 (Phosphotyrosine protein) phosphatases II 156-269 4.4e-07 25.0 In-house 161-291 (308) alignment 
Range on Protein: 156-269
Range on HMM: 161-291/308.0
DSRHLDHYTVYNLSPKSYRTAKFHSRVSEC---------------SWPIRQAPS-LHNLFAVCRNMYNWLlqnPKNVCVVHCLDGRAASSILVGAMFI--
.|.. ...||..|| ... . .      ..               .||  ..|. .  |.. .. . ..|   |....|||| .|   .  .. .  .  
gsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllle

--FCNLYSTPGPAIRLLYAKRPGIGLSPSHRRYL
   ..   ..  |.. |  .|||   .|.. ..|
qlekeggvdvfeavkklReqRpgmvqtpeqylfl
0036941 (Phosphotyrosine protein) phosphatases II 158-275 2.6e-06 22.4 In-house 145-274 (297) alignment 
Range on Protein: 158-275
Range on HMM: 145-274/297.0
RH--LDHYTVYNLSPKS--YRTAKFHSRVSECSWPIRQAPS-LHNLFAVCRNMYNWLLQN-PKNVCVVHCLDGRAASSILVGAMFIFCNLY-------ST
 .  ||.||...|  .   .   ..       .||   .|.    |.. .. . ..| .  .... .||| .|   |  ...|  ... |         .
evvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvd

PGPAIRLLYAKRPGIGLSPSHRRYLgYMCDL
.  |.. |  .|||.  .... |.| |.. |
ileavkklReqRpgavqtleqyrfl.yeall
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 284-420 4.3e-30 95.6 Pfam-A 2-132 (134) alignment 
Range on Protein: 284-420
Range on HMM: 2-132/134.0
HFKPLTIKSITVSPIPFFnKQRNGCRPYCDVLIGETKIYSTCTDFERMKEYRVQDGKIFIPLNITVQGDVVVSMYHLRSTigsrlqaKVTNTQIFQLQFH
. |.|..|||....||.| |.|.||.|.. |  |..|. ....... ..|.| ..  . .| ...|.|||.| ..| .|.       .... .||...|.
npkrlelksiilegiPnf.ktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsk.......lpkkekifrvwFN

TGFIPLDTTVLKFTKPELDACDVP--EKYPQLFQVTLDV
| ||. ...||...| ||| ..    .|... |.|.| .
TsFieknqnvltlpkneLDkalkdkdkkfsknfkvelvf
DnaJ DnaJ domain 918-965 5e-10 28.3 Pfam-A 13-58 (64) alignment 
Range on Protein: 918-965
Range on HMM: 13-58/64.0
TPEQVKKVYRKAVLVVHPDKATGQPyeQYAKMIFMELNDAWSEFENQG
. |..|| ||| .| .||||. ...  . |.  | |.|.|..  ... 
sdeeIkkaYrklalkyHPDknkdde..eeaeekfkeineAyevLsdpe