Gene GAK in Homo sapiens

Synonym: DNAJ26, DNAJC26, GAK

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Auxilin
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP063_AA protein Get Run
HsapP063_AA_396-565 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Pkinase_Tyr Protein tyrosine kinase 41-313 3.8e-32 101.3 Pfam-A 2-259 (259) alignment 
Range on Protein: 41-313
Range on HMM: 2-259/259.0
RVRRVLAEGGFAFVYEAQDV----GSGREYALKRLLSNEEEK-NRAIIQEVCFMKKLsGHPNIVQFCSAASigKEESdtgqaeFLLLTELCK-GQLVEFL
.. . |.|| |. |.|..       .  . |.| | ...||. ......|. .||||  |.|||..  . .  |||.      .|..||... |.| .||
elgkklGeGafGeVvegtlkgekekkevkVavKtlkeeaeeeekeefleeakimkkl.khenivkllgvct..keep......llivteyvegGdLlkfL

KKMeSRGPLSCDTVLKIFYQTCRAVQHMHRQKppIIHRDLKVENLLLSNQGTIKLCDFGSATTIshypdyswsA----QrralvEEEITRNTTPMYRTPE
.|  .. .|. ...|.. .| ..........|  ..||||   | ||......|..||| | .|              .     ... ....   .  ||
rkk.ekekltledllsfalqiAkGmeyLeskk..lvHrdLaarNvLleenkvvkisDfGLardi.........ekddyy.....kkkekaklpvkWmapE

IIDLYSnfpIGEKQDIWALGCILYLLC-FRQHPFEDGAKLR---IVNGKYSIPPHDTQYTVFHSLIRAMLQVNPEERLSIAEVVHQL
...  .   . .| |.|. | .|. .. . ..|...  . .    .. .. ..  ..  . ...|..  .. .||.| ...|.|..|
slkekk...ftsksDvWsfGvllwEiftlgespypglsneevleklkegkrlekpencpeelyelmkqCweeepekRptfkelvekl
Pkinase Protein kinase domain 42-312 1.4e-53 171.7 Pfam-A 3-257 (260) alignment 
Range on Protein: 42-312
Range on HMM: 3-257/260.0
VRRVLAEGGFAFVYEAQDVGSGREYALKRLLSNEEEKNRAI--IQEVCFMKKLsGHPNIVQFCSAASIgkeesdtgQAEFLLLTELCKG-QLVEFLKkme
. . | .|.|. ||.|.. ..|...|.|.|  .||... ..  ..|.. .|||  |||||.. ..           . |..|..|...| .| ..||   
lleklGsGsfGkVykakekktgkkvAvKilkkeeekskkektalrElkilkkl.nHpnivkllevfee........kdelylvleyveggdlfdllk...

SRGPLSCDTVLKIFYQTCRAVQHMHRQkpPIIHRDLKVENLLLSNQGTIKLCDFGSATTIshypdyswsaqrRALVEEEITRNTTPMYRTPEIIDlySNF
..|.|| ... ||..|........|..   ||||||| ||.||...|..|..|||.| ..                |.  |.  |. |. ||..   .. 
kkgklseeeikkialqilegleylHsn..giiHrDLKpeNiLldekgelkiaDFGlakkl............eksseklttlvgtreYmAPEvll..kak

PIGEKQDIWALGCILYLLCFRQHPFEDG---AKLRIVNGKYS-IPPHDTQ-----YTVFHSLIRAMLQVNPEERLSIAEVVHQ
 ...| |.|.||.||| |.... ||..     .|.... . .   ..| .      . . .||. .|. .|..||...|....
eytkkvDvWslGvilyelltgklpfsgeseedqlelirkilkkkleedepkssskseelkdlikkllekdpakRltaeeilkh
Kinase-like Kinase-like 129-303 3.7e-09 25.0 Pfam-A 128-289 (289) alignment 
Range on Protein: 129-303
Range on HMM: 128-289/289.0
QLVEFLKKMESR-GPLSCDTVLKIFYQTCRAVQHMHRQKppIIHRDLKVENLLLSNQGTIKLCDFgsaTTISHYPDYSW-SAQRRALVEEEITRNTTPmY
.||..|.| ...  .|     | .  |. | ..... .   ..| .....|.|| ..| ..| .|   |..  . ..   |   .||  .|....    |
tlvkllqkrkeehkkletaarllLTlqlirlaanLqarg..lvhgkispdnflldekggvfLggf...taLvragkkvvvsevekalaPpellaekgg.y

RTpEiidlysNFPIGEKQDIWALGCILYLLCFRQHPFEDGAKLRIVNGKYSIPPhDTQYTVfHSLIRAMLQVNPEER
.. .      .. . .| | |.||  .|..  .. ||.  |.  . . |..         | . |.. .|| . |.|
ts.n......ttkmthkldaWqlGlviysiwclrlPftllaeeaseewkfklck.kvpekv.klLvkklLqrsqeaR
PTEN_1 397-565 1.7e-34 114.4 In-house 9-194 (196) alignment 
Range on Protein: 397-565
Range on HMM: 9-194/196.0
IQSVANYAKGDLDISYITSRIAVMS-FPAEG-----VESALKNNIEDVRLFLDSKHPGH-YAVYNLSPRT------YRPSR-FHNRVS--ECGWAARRAP
 ..   . . .||..|||||| .|. .|...      |. ......||. .||.... . ..|.|||..       |...  |...|.  ....    ||
skknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgap

HLHTLYNICRNMHAWLRQDH-KNVCVVHCMDGRAASAVAVCSFLCFCRLfSTAEAAVYMFSMKRCPPGIW-PSHKRYIEYMCDMVAE
 |. |  ||.... ||..|  .||..|||  |.  |.. |...|....  .||. |. ..  ||.| ..  ||..|..||  .. ||
slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapnspsqerlleyfaellae
subfamily_Auxilin_pd Subfamily Auxilin 400-564 6.9e-89 288.8 In-house 1-165 (166) alignment 
Range on Protein: 400-564
Range on HMM: 1-165/166.0
VANYAKGDLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQD
||.|||.||||||||||| |||||||||||..||||.|||.||.|.||..|.|||||.||||......||.|.||.|||||.|..|...|||...||..|
vasyakndlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkd

HKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYMCDMVA
.|||.||||.|||||||| |...|.||||.|..|.||..||.||.|.|..||.|||.||..|..|
pknvvvvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpiglspsekryleyladlla
0046845 (Phosphotyrosine protein) phosphatases II 401-556 7.3e-10 34.2 In-house 62-266 (284) alignment 
Range on Protein: 401-556
Range on HMM: 62-266/284.0
ANYAKGD-LDISYITSRIAVMSFPAEG-----------------------------VESALKNNIEDVRLF-------LDSKHPGHYAVYNLSPRT---Y
|.| .|  ||..||. .. ....| ..                               .   .....|  .       |. .. ..| |..|. .     
AsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgyt

RPSRFHNRVSECGWAARRAPH-LHTLYNICRNMHAWLRQ-DHKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTA-------EAAVYMFSMKRCPPGIWPS
 .||...     .|  . .|. .  | ...| .. .|.. . ... ||||..|   ... ..  |....|  .        . ||... ..|.     ..
gesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtle

HKRYI
. |..
qyrfv
0043336 (Phosphotyrosine protein) phosphatases II 403-555 3.3e-13 45.2 In-house 66-266 (278) alignment 
Range on Protein: 403-555
Range on HMM: 66-266/278.0
YAKGDLDISYI----------TSRIAVMSFPAEGVESALKNNIEDVR----------------------------------LFLDSKHPGHYAVYNLSPR
  .|||| .||          . .. ....| .. .    . . . .                                   .|. .| ..| |..|   
llggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevt

--TYRPSRFHNRVSECGWAARRAP-HLHTLYNICRNMHAWLRqDHKNVCVVHCMDGRAASAVAVCSFLCF----CRLFSTAEAAVYMFSMKRcpPGIWPS
   . .||.....   ||    .| .| .| .... .. .|. | ... .|||..|   ... .. .|..     ... ..| || .. ..|  ||. ..
nlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR..pgavqt

HKRY
   |
psqy
0039614 (Phosphotyrosine protein) phosphatases II 404-555 4.8e-16 54.5 In-house 58-280 (297) alignment 
Range on Protein: 404-555
Range on HMM: 58-280/297.0
AKG---------------------DLDISYI-----------TSRIAVMSFPAEG-----VESALKNNIEDVR---------------------------
 |                      ||| .||           | .. ....| ..      .   ..... .                            
dknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdft

-LFLDSKHPGHYAVYNLSPRTYRPSRFHNRVSECGWAARRAP-HLHTLYNICRNMHAWLRQD-HKNVCVVHCMDGRAASAVAVCSFLCF----CRLFSTA
  .|. .| ..| |..|. . . .||.....   ||    .| .| .|..... .. .|...  .....|||..|   ... .. .|..    ..   ..
vtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdv

EAAVYMFSMKRcpPGIWPS--HKRY
. || .. ..|  ||. ..  . |.
leavkelreqR..pgavqtpsqyrf
0040438 (Phosphotyrosine protein) phosphatases II 404-558 4.5e-10 34.8 In-house 65-270 (317) alignment 
Range on Protein: 404-558
Range on HMM: 65-270/317.0
AKGDLDISYI----------TSRIAVMSFPAEG-----VESALKNNIEDVRLFLDSK------------------------------HPGHYAVYNLSPR
 .|||| .||          . .. ....| ..      .   ..... .  . ...                              . ... ...|   
lggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtleve

--TYRPSRFHNRVSECGWAARRAP-HLHTLYNICRNMHAWLRqDHKNVCVVHCMDGRAASAVAVCSFLCF----CRLFSTAEAAVYMFSMKRCPPGIWPS
     .||. .     ||    .| .. .| .... ....|. |......|||..|   ... .. .|..     . . ..| ||... ..|.     |.
dlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpe

HKRYIEY
. |.. .
qyrflyd
subfamily_Tensin_pd Subfamily Tensin 405-582 2.4e-44 144.1 In-house 8-189 (189) alignment 
Range on Protein: 405-582
Range on HMM: 8-189/189.0
KGDLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVC
| |||..|||.|| ..||||||.|.. ..|..||  .|.|||  .| |.||| . |  |.....| . ||    || |  |  ||.....||..| .|| 
kvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkadpqnvv

VVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRC-----PPGIWPSHKRYIEYMCDMVAEEpITPHSKPILVRAVVM
||||  |.   .| | ... . .. ..|.||.  |.|||       . . ||..||.||. .... . |   |.|...  |..
vvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgk.iklnssplflhyvil
subfamily_PTEN_pd Subfamily PTEN 405-565 5.3e-42 138.9 In-house 17-181 (184) alignment 
Range on Protein: 405-565
Range on HMM: 17-181/184.0
KGDLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNL-SPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNV
. |||.||||..| .|..|||..|.. .|..|||  ||..|| .|| .||| | |.|  ..|..||....     .|.|. | .|......|| .|.|||
gldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkknv

CVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRCPP--GI-WPSHKRYIEYMCDMVAE
 ||||. |.  . | ....|  ..|...|| |. .|. .|     |.  || .||.||. ... |
vvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyekllee
0042113 (Phosphotyrosine protein) phosphatases II 405-555 1.2e-13 46.5 In-house 32-234 (245) alignment 
Range on Protein: 405-555
Range on HMM: 32-234/245.0
KGDLDISYI----------TSRIAVMSFPAEGVES-----ALKNNIEDVR------------------------------LFLDSKHPGHYAVYNLSPR-
.|||| .||          | .. ....|...          ...|. .                                .|. .| ..| |..|.   
ggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtn

-TYRPSRFHNRVSECGWAARRAPH-LHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVAVCSFLCF----CRLFSTAEAAVYMFSMKRcpPGIWPS-
  . .||.....   .|    .|. | .| .... .. .|..| .....|||..|.  ... .. .|..     .|  ..| ||... ..|  ||. .. 
lgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqR..pgavqtp

-HKRY
 . |.
sqyrf
0046846 (Phosphotyrosine protein) phosphatases II 406-561 6.2e-16 54.1 In-house 8-170 (176) alignment 
Range on Protein: 406-561
Range on HMM: 8-170/176.0
GDLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSkhpGHYAVYNLSPRT-----------YRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHA
 |||..||. .....|.|. . ..  ..  ........    |..|| ||  ..            .  ... ..  ..|    .| |  |..... .. 
ldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefire

WLRQDhkNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRC-PPGIWPSHKRYIEYMCD
.|...  .. .|||. |.  ... |. .|. .. . ..| |.... ..|.      |.. |.....  
alkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefel
subfamily_VSP_pd Subfamily VSP 407-562 1.9e-37 123.3 In-house 33-197 (212) alignment 
Range on Protein: 407-562
Range on HMM: 33-197/212.0
DLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNL-SPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCV
|||..|.| ||  ||||. | .|  .| |..|  ||| ||. || |.|| | |.| .. |.|||...       |.|. | ....... || .|.||| .
dldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlekdlknvla

VHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRCPPG-------I-WPSHKRYIEYMCDM
.||  |.  .  .||..|    .|.||. ... |. .|   .       .  || |||..|. ..
ihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqv
0036282 (Phosphotyrosine protein) phosphatases II 407-561 2.8e-28 94.2 In-house 9-167 (174) alignment 
Range on Protein: 407-561
Range on HMM: 9-167/174.0
DLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRT-YRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCV
.||.||||.|. ....|.. .|   ...|..|  .|..|..|.| ..|. |.. . ..|.. ..  ..|  . .| |..|..... .. .| .|......
pldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvl

VHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKR---CPPGIWPSHKRYIEYMCD
|||. |.  ... |. .|. ..|..... |.... ..|   ..  ..||. |.. |...
VHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
0041856 (Phosphotyrosine protein) phosphatases II 407-559 1.1e-15 53.1 In-house 16-166 (182) alignment 
Range on Protein: 407-559
Range on HMM: 16-166/182.0
DLDISYITSRIAVMSFPAEGVESALKNNIEDVRLFLDSKHPGHY-AVYNLSPRTYRPSRFHN---RVSECGWAARRAPHLHTLYNICRNMHAwlrqdHKN
..|..||. .. ..|.||   . .  . ...|  ||.  .  .. .. ||... | |.....   ..   .|    .| |..|..... ...     ...
srdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....egg

VCVVHCMDGRAASAVAVCSFLCFCRlFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYM
...|||. |.  ... |. .|. ..   ..| || .. ..|.   | |.. ... ..
pvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrRpgmvitpnqyfflqla
0043147 (Phosphotyrosine protein) phosphatases II 407-557 2.7e-14 48.7 In-house 12-154 (172) alignment 
Range on Protein: 407-557
Range on HMM: 12-154/172.0
DLDISYITSRIAVMSFPaegvesaLKNNIEDVRLFLDSKHPGHyaVYNLSPR---TYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNV
.||..||. |. .. .|       | |...|.. .| ... .|  ..|| ..   ..  .|.  ..  ..|    .|.|  |..... .. .| .. ...
yldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggp

CVVHCMDGRAASAVAVCSFLCFCRLfsTAEAAVYMFSMKRCPPGIWPSHKRYIE
..|||. |   ... |. .|. ..|  ..| || .. .||.     ||. |.. 
vlVHCsaGvgRtgtlvaaylmllgl..sleeavalvrekRpgavqnpsqyrfly
0037934 (Phosphotyrosine protein) phosphatases II 407-559 2.6e-13 45.6 In-house 36-237 (243) alignment 
Range on Protein: 407-559
Range on HMM: 36-237/243.0
DLDISYITSRIAVMSFPAEGVESA---------LKNNIEDVR----------------------------LFLDSKHPGHYAVYNLSPRT---YRPSRFH
... .|.| |. ....| ..              ...|. .                              .|...| ..| |..|. .    . ..|..
nanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlv

NRVSECGWAARRAPH-LHTLYNICRNMHAWLRQ-------DHKNVCVVHCMDGRAASAVAVCSFLCFCRLFSTAEAAVYMFSMKRCP-PGIWPSHKRYIE
 ..   .|    .|     |..... .......       |......|||. |.  ... .. .|.  .|  ..| || .. ..|.      ||. |.. 
ihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrfly

YM
..
ea
0045098 (Phosphotyrosine protein) phosphatases II 407-552 5.9e-10 34.5 In-house 6-258 (278) alignment 
Range on Protein: 407-552
Range on HMM: 6-258/278.0
DLDISYITSRIAVMSFPAEGVESALKNNIE----------------------------------------------------------------------
.||..... .. ....| |  .. . .|..                                                                      
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrek

---------------------DVRLFlDSKHPGHYAVYNLSPRTYRPSRFHNRVSEC-GWAARRAPHLH---TLYNICRNMHAWLR------------QD
                     ..  . |  .  .. |.||. . .    .. ..  . .|    .|.|.    . .... ....|.            .|
caqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllld

HKNVCVVHCMDGRAASAVAVCSFLCFCR---LFStAEAAVYMFSMKRcpPG-IWPSH
......|||. |   ... |. .|. ..    .. .. || .. ..|  || .... 
sggpvlVHCsaGvgRtGtlvaaylmlelleggvd.lleavkelrsqR..pglavqnl
0044763 (Phosphotyrosine protein) phosphatases II 407-560 9.5e-10 33.9 In-house 20-167 (178) alignment 
Range on Protein: 407-560
Range on HMM: 20-167/178.0
DLDISYITSRIAVMSFPAegvesalknnIEDVRLFLDSKHPghyAVYNLSP---------RTYRPSRFHNRVSECGWAARRAPH-LHTLYNICRNMHAWL
 ...|.|. .. ..|.|.           .|..|. . .     .. ||..           | |.... ..  ...    .|  |  ...... ....|
yinaseilpglylgslpp..........addlellkelgit...hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieeal

RQDHkNVCVVHCMDGRAASAVAVCSFLCFCRLFsTAEAAVYMFSMKRCpPGIWPSHKRYIEYMC
 ... ....|||. |.  |.. |. .|. .. . ..|.|. .. ..|.   . |.. |..... 
dekg.gpvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerRp.ivpnpgqlrqLyefe
0051082 (Phosphotyrosine protein) phosphatases II 408-559 3.1e-14 48.3 In-house 6-147 (151) alignment 
Range on Protein: 408-559
Range on HMM: 6-147/151.0
LDISYITSRIAVMSFPAEgvesalknnieDVRLFLdsKHPGHYAVYNLSPRT---YRPSRFHN---RVSECGWAARRAPHLHTLYNICRNMHAWLRQDHK
...||.|... ....| .           |.  .|  |. |.....|| . .   | |.....   .|  . .    .| | .......... .|... .
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NVCVVHCMDGRAASAVAVCSFLCFCRlfSTAEAAVYMFSMKRCpPGIWPSHKRYIEYM
....|||. |.  ... |. .|. ..   ..|.|. .. .||.   ..|.  ......
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp.gvvqpnqqflfqlf
0040439 (Phosphotyrosine protein) phosphatases II 408-550 2.5e-10 35.9 In-house 47-230 (249) alignment 
Range on Protein: 408-550
Range on HMM: 47-230/249.0
LDISYITSRIAVMSFPAEGVESALKNNIEDVR-----------------------------------LFLDSKHPGHYAVYNLSPR--TYRPSRFHNRVS
.| .||. |. ....| ..  ..  . . . .                                    .|. .. ..| |..|      . .||  . . 
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

ECGWAARRAP-HLHTLYNICRNMHAWLRQD-HKNVCVVHCMDGRAASAVAVCSFLCF----CRLFSTAEAAVYMFSMKRcpPGIWP
  .|    .| .. .| .... .. .|...  .....|||..|   ... .. .|..     .|  ..| || .. ..|  ||. .
ytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqR..pgavq
0038934 (Phosphotyrosine protein) phosphatases II 412-558 2e-22 75.2 In-house 15-168 (194) alignment 
Range on Protein: 412-558
Range on HMM: 15-168/194.0
YITSRIAVMSFPAEG-----VESALKNNIEDVRLFLDSKHPGHYAVYNLS--PRTYRPSRFHN---RVSECGWAAR-RAPHLHTLYNICRNMHAWLRQDH
.|| |. ....|..|     .|. .....||.  .|.... ....|..|.   |.| |..|..   .. .. .  .  .| | .|..... .. .|..| 
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

KNVCVVHCMDGRAASAVAVCSFLCFCRLFsTAEAAVYMFSMKRcPPGIWpsHKRYIEY
..|..|||. |.  ... |...|  .. . .||.|...|..|| |..|.  .  |.|.
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR.pgaip..nqdylea
0045450 (Phosphotyrosine protein) phosphatases II 413-551 2.5e-11 39.3 In-house 144-289 (307) alignment 
Range on Protein: 413-551
Range on HMM: 144-289/307.0
ITSRIAVMSFPAEGVESALKNnieDVRLFLDSKHPGHYAVYNLSPR---TYRPSRFHNRVSECGWAARRAP-HLHTLYNICRNMHAWLRQD-HKNVCVVH
 .... .. .| || |   .|   ..  .|. .| ..| |..|         .||...     ||    .| .. .| .... ....|...  .....||
lgrekcaqywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVH

CMDGRAASAVAVCSFLCFCRLF-------STAEAAVYMFSMKRcpPGIWPS
|..|   ... .. .|. ..|         ... || .. ..|  ||. ..
CsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqR..pgavqn
0049260 (Phosphotyrosine protein) phosphatases II 420-557 3.7e-11 38.4 In-house 7-143 (152) alignment 
Range on Protein: 420-557
Range on HMM: 7-143/152.0
MSFPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNL-SPRTYRPSRFHNRVSECGWAARRAPHLHTLYNICRNMHAWLRQDHKNVCVVHCMDGRAASAVA
|.|.. . .  . |...|.  .| . . ... ...  .....    .. ..  . |    .| |. |  ..  .. .|..| .....|||. |   ... 
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtl

VCSFLCFcrLFSTAEAAVYMFSMKRCPPGIWPSHKRYIE
|. .|.   |  ..| || .. .||    . |.. |.. 
vaaylml..lgvsleeavalvrekRpgavpnpgqlrfly
0048076 (Phosphotyrosine protein) phosphatases II 422-558 7.8e-12 40.6 In-house 3-137 (145) alignment 
Range on Protein: 422-558
Range on HMM: 3-137/145.0
FPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFHNRVSECGWAARRAPHL-HTLYNICRNMHAWLRQDhkNVCVVHCMDGRAASAVAVC
.|.| ...   ... ... .   |. |...|.||.. .. ..|.. ..  ..|  . .| |  .|..... ....|...  ....|||. |.  ... |.
wpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlva

SFLCFCRLfSTAEAAVYMFSMKRCPPGIWPSHKRYIEY
 .|....   ..| |. .. ..|    . |.. |....
aylmlllg.vsleealelvrsqrpgavpnpgqlrflye
0048179 (Phosphotyrosine protein) phosphatases II 422-558 2.5e-11 39.0 In-house 3-139 (144) alignment 
Range on Protein: 422-558
Range on HMM: 3-139/144.0
FPAEGVESALKNNIEDVRLFLDSKHPGHYAVYNLSPRTYRPSRFHN--RVSECGWAARRAPHL-HTLYNICRNMHAWLRQDhkNVCVVHCMDGRAASAVA
.|.| ...   ... ... .   |. |...|.||..  . ..  ..  ..  ..|  . .| | . |..... ....|...  ....|||. |.  ... 
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtl

VCSFLCFCRLfSTAEAAVYMFSMKRCPPGIWPSHKRYIEY
|. .|....   ..| |.... ..|.   . |.. |....
vaaylmkklg.lsleealalvrsrrpgavpnpgqlrfLle
0049772 (Phosphotyrosine protein) phosphatases II 432-552 5.8e-09 31.6 In-house 167-260 (314) alignment 
Range on Protein: 432-552
Range on HMM: 167-260/314.0
KnniedvrlfldskhpghyavynlsPRTYRPSRFHNRVSEC---GWAARRAPHLHTLYNICRNMHAWlrqDHKNVCVVHCMDGRAASAV-AVCSFLCFCR
|                        ...| |..| ... .     .    || |  .. ... ....   | ... .|||..|.  ... .|. .|. ..
k........................eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll

LFsTAEAAVYMFSMKRCppgIWPSH
 . ..| |. .. .||    |.|..
gv.sleealedvrlkRp...inpnp
0051299 (Phosphotyrosine protein) phosphatases II 441-538 7.7e-08 27.6 In-house 153-260 (288) alignment 
Range on Protein: 441-538
Range on HMM: 153-260/288.0
FLDSKHPGHYAVYNLSPR------TYRPSRFHNRVSECGWAARRAPH-LHTLYNICRNMHAWLRqDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFST--
.|. .. ..| |..|  .          ||. .     .|    .|. .  | ...| .. .|. ......||||..|   ... .. .|....|  .  
llseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekegg

--AEAAVYM
  .. || .
vdvleavkr
0047943 (Phosphotyrosine protein) phosphatases II 442-544 6.1e-09 31.2 In-house 142-252 (273) alignment 
Range on Protein: 442-544
Range on HMM: 142-252/273.0
LDSKHPGHYAVYNLSPRT--YRPSRFHNRVSECGWAARRAP-HLHTLYNICRNMHAWLRQD-HKNVCVVHCMDGRAASAVAVCSFLCF-----CRLFStA
|. .. ..| |..|  .   .  ||. . .   ||    .| .|  | .... .. .|... .... ||||..|   ... .. .|..      . .. .
lseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvd.v

EAAVYMFSMKRC
. ||... ..|.
leavkllrsqRp
0036941 (Phosphotyrosine protein) phosphatases II 447-538 8.7e-06 20.7 In-house 149-252 (297) alignment 
Range on Protein: 447-538
Range on HMM: 149-252/297.0
PGHYAVYNLSPRT--YRPSRFHNRVSECGWAARRAPH-LHTLYNICRNMHAWLRQD-HKNVCVVHCMDGRAASAVAVCSFLCFCRLF--------STAEA
 ..| ...|      . .||. .     ||    .|.   .| .... .. .|..   ... .|||..|   |.. .. .|....|         .  ||
lddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdilea

AVYM
  ..
vkkl
subfamily_RNGTT_pd Subfamily RNGTT 481-561 3e-06 21.0 In-house 96-169 (189) alignment 
Range on Protein: 481-561
Range on HMM: 96-169/189.0
HLHTLYNICRNMHAwlrQDHKNVCVVHCMDGRAASAVAVCSFLCFCRLFStAEAAVYMFSMKRcPPGIWpsHKRYIEYMCD
. ... ..... ..   .  ..|  |||  |   .   ..|.|   . .| .|||| .|.. | ||||   .. |.. ...
qvkefiklveeffk...knpeevigvhCthGfnRtGFlivsyLvekedws.veaavalFakaR.ppGiy..kedylkellr
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 571-707 8.3e-28 88.2 Pfam-A 2-132 (134) alignment 
Range on Protein: 571-707
Range on HMM: 2-132/134.0
HSKPILVRAVVMTPVPLFsKQRSGCRPFCEVYVGDERVASTSQEYDKMRDFKIEDGKAVIPLGVTVQGDVLIVIYHARSTlggrlqaKMASMKMFQIQFH
..|.. ...... ..| | |.|.||.|...|| |.. | .....| .... . ..    .| ...|.||||. ..| .|.       ..   |.|...|.
npkrlelksiilegiPnf.ktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsk.......lpkkekifrvwFN

TGFVPRNATTVKFAKYDLDACDIQ--EKYPDLFQVNLEV
| |...| ..... |..|| .. .  .|... |.|.| .
TsFieknqnvltlpkneLDkalkdkdkkfsknfkvelvf
DnaJ DnaJ domain 1261-1308 1.2e-10 30.3 Pfam-A 15-60 (64) alignment 
Range on Protein: 1261-1308
Range on HMM: 15-60/64.0
EQVKKHYRRAVLAVHPDKAAGQPyeQHAKMIFMELNDAWSEFENQGSR
|..|| ||. .| .||||. ...  ..|.  | |.|.|..  ... .|
eeIkkaYrklalkyHPDknkdde..eeaeekfkeineAyevLsdpekr