Gene PTEN in Homo sapiens

Synonym: 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1, PTEN

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily PTEN
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP064_AA protein Get Run
HsapP064_AA_3-211 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_VSP_pd Subfamily VSP 3-182 2.2e-69 227.6 In-house 14-198 (212) alignment 
Range on Protein: 3-182
Range on HMM: 14-198/212.0
AIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIK
 ... .||.|||||..|||||||||.   |||| ||.   . .||| |..|.|||| ||..|||..|||.||.|| . || || .   .||| |.|| . 
kaarrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleell

PFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDK-----KGVTIPSQRRYVYYYSYLL
 |.... .||..| ..| ||||| |||||| ..||.||. . | .|.|.||..|| ||  .     .||  |||.||| |.  . 
vftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvk
0037934 (Phosphotyrosine protein) phosphatases II 4-179 2.2e-39 130.9 In-house 4-238 (243) alignment 
Range on Protein: 4-179
Range on HMM: 4-238/243.0
IIKEIVSRNKRRYQ--------------EDGFDLDLTYIYPNIIAMGFPAER---------LEGVYRNNIDDVV--------------------------
|.. .....|.||.              .| ....|.|..|..||...| .          .. .....|. .|                          
iallpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdf

--RFLDSKHKNHYKIYNLCAER--HYDTAKFNCRVAQYPFEDHNPPQ-LELIKPFCEDLDQWLSE-------DDNHVAAIHCKAGKGRTGVMICAYLLHR
  ..|...|...|....|. |.  ..|  ...... ..|. ||..|.  | .  |.... ....|       |.... ..||.||.||||..|.|||...
tvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmll

G-KfLKAQEALDFYGEVRTRdkKGVTIPSQRRYVYYYS
  . . ..||.... | |    |.|..|||.|..|.. 
llg.vdleeavkllreqRpg..kavqtpsqyrflyeal
subfamily_PTEN_pd Subfamily PTEN 5-185 5.6e-90 295.2 In-house 2-182 (184) alignment 
Range on Protein: 5-185
Range on HMM: 2-182/184.0
IKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPF
...|||..|.|..|||.||||.||..||||||.|||.||..|||...|||.||..|||.|||||||..||.||..||..|||.|||.|||||.|||....
lrkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleei

CEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNH
.||...||.||...|...|||||||||||.|.||||..... ||.|||... |.||..|||||||||||||.||. ||...
vediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyeklleee
0049772 (Phosphotyrosine protein) phosphatases II 6-184 2.5e-30 101.7 In-house 85-279 (314) alignment 
Range on Protein: 6-184
Range on HMM: 85-279/314.0
KEIVSRNKRRYQEDGF-----------------DLDLTYIYP---------------------NIIAMGFPaerlegvyrnniddvvRFLDS------Kh
| |...... .  . |                 ||.. .|..                     ..|..|..                 ...       | 
kfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng................neptaadlellk.

knhykiynlcaERHYDTAKFNCRVAQY---PFEDHNPPQLELIKPFCEDLDQWlseDDNHVAAIHCKAGKGRTGV-MICAYLLHRGKFlKAQEALDFYGE
           |..||  .|  .. .|   |..|...| || .. |.| ....   |.... ..||||||||||. ...|||... ..  ..|||... .
...........eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkllgv.sleealedvrl

VRTRDKKGVTIPSQRRYVYYYSYLLKN
 |.   . ..|.....|.... .||. 
kRpinpnpgfieqleqyefilealley
0039614 (Phosphotyrosine protein) phosphatases II 7-183 3.1e-38 127.3 In-house 53-289 (297) alignment 
Range on Protein: 7-183
Range on HMM: 53-289/297.0
EIVSRNKRRYQ--------------EDGFDLDLTYI-----------YPNIIAMGFPAER-----LEGVYRNNIDDVV----------------------
 .....|.||.              |||.|||..||            ...||...| .      .. |.....  .|                      
lpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggt

------RFLDSKHKNHYKIYNLCAERhYDTAKFNCRVAQYPFEDHNPP-QLELIKPFCEDLDQWLSED-DNHVAAIHCKAGKGRTGVMICAYLLH----R
      ..|. .|...|....|. .. ..  ..  ..  ... ||..|  |||.  |.| ....|.|. .... ..||.||.||||..|.|||..    .
ygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlek

GKFLKAQEALDFYGEVRtrdKKGVTIPSQRRYVYYYSYLLK
.. . ..||.... | |    ..|..||| |..|.. . | 
eggvdvleavkelreqR...pgavqtpsqyrflydallell
0042113 (Phosphotyrosine protein) phosphatases II 7-180 3e-36 120.5 In-house 6-240 (245) alignment 
Range on Protein: 7-180
Range on HMM: 6-240/245.0
EIVSRNKRRY-------------QEDGFDLDLTYI----------YPNIIAMGFPAERLEG-----VYRNNIDDVV------------------------
 .....|.||             ..||.|||..||          .|..||...|..   .     .....|  .|                        
lpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgeslt

------RFLDSKHKNHYKIYNLCAER-HYDTAKFNCRVAQYPFEDHNPPQ-LELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLH----R
      ..|. .|...|....|. ..  .|  ...... ..|..||..|  |||.  |.| ....|.||.|.. ..||.||.||||..|.|||..    .
ygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlek

GKFLKAQEALDFYGEVRtrdKKGVTIPSQRRYVYYYSY
 . . ..||.... . |    . |..||| |..|.. .
elgvsleeavkelrsqR...pgavqtpsqyrflyeall
PTEN_1 9-184 5.5e-53 174.7 In-house 6-194 (196) alignment 
Range on Protein: 9-184
Range on HMM: 6-194/196.0
VSRNKRRYQEDGFDLDLTYIYPNIIAMG-FPAER-----LEGVYRNNIDDVVRFLDSKHKNH-YKIYNLCAERHY-----DTA-KFNCRVA--QYPFEDH
 ...|... .....||||||.. ||||| .|..       ||.||....||...||...... . ..||. |...     |    |. .|   ..|.|||
krsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDh

NPPQLELIKPFCEDLDQWLSEDD-NHVAAIHCKAGKGRTGVMICAYLLHRGKfLKAQEALDFYGEVRTRDKKGvtIPSQRRYVYYYSYLLKN
..| |. .  .|.....||..|. ..|...|||||.||.|....|||...|| | |.|||... | |..  .   .|||.|...|.. ||..
gapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn..spsqerlleyfaellae
0040438 (Phosphotyrosine protein) phosphatases II 9-211 6.5e-37 122.9 In-house 42-305 (317) alignment 
Range on Protein: 9-211
Range on HMM: 42-305/317.0
VSRNKRRY-------------QEDGFDLDLTYI----------YPNIIAMGFPAER-----LEGVYRNNIDDVVRFLDSK--------------------
....|.||             . .|.|||..||           ...||...| .      .. |.....  .|.. ...                    
enkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltyg

----------HKNHYKIYNLCAERHYDTAKFNCRVAQYPF-EDHNPP-QLELIKPFCEDLDQWLSeDDNHVAAIHCKAGKGRTGVMICAYLLH----RGK
          .........|. | ..|  .. ... .|..  ||..|  ..|.  |.| ....|. |.... ..||.||.||||..|.|||..    ...
dftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg

FLKAQEALDFYGEVRtrdKKGVTIPSQRRYVYYY-SYLLKNHLDYRPVALLFHKMMFETIPMFSGGTC
.. ..||.... | |    ..|. |.| |..|..  ..||..| . |.  |..|.. ..||.. ..  
gvdveeavkelreqR...pgavqtpeqyrflydalleylkrkltlepaselklkllklliplalddvk
0043336 (Phosphotyrosine protein) phosphatases II 9-178 1.6e-33 111.8 In-house 44-272 (278) alignment 
Range on Protein: 9-178
Range on HMM: 44-272/278.0
VSRNKRRY-------------QEDGFDLDLTYI----------YPNIIAMGFPAERLEGVYRNNIDD---------------------------------
 ...|.||             . .|.|||..||           ...||...| .  .. ... . .                                 
enkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygd

-VVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQY-PFEDHNPP-QLELIKPFCEDLDQWLSeDDNHVAAIHCKAGKGRTGVMICAYLLH----RGKF
 .|..|. .|...|....|. ....|  .. ... .| .. ||. | .|.|.  |.......|. |.|.. ..||.||.||||..|..|||.    ....
ftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekegg

LKAQEALDFYGEVRtrdKKGVTIPSQRRYVYYY
. ..||.... | |    . |. ||| |..|..
vdleeavkelreqR...pgavqtpsqyrflyea
0040439 (Phosphotyrosine protein) phosphatases II 9-180 4.4e-31 103.8 In-house 10-243 (249) alignment 
Range on Protein: 9-180
Range on HMM: 10-243/249.0
VSRNKRRYQ---------------EDGFD--------LDLTYIYPNIIAMGFPAERLEGVYRNNIDD---------------------------------
....|.||.               ...|.        .|..|| ...||...| .   . ... . .                                 
enkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleyg

--VVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQY-PFEDHNPP-QLELIKPFCEDLDQWLSED-DNHVAAIHCKAGKGRTGVMICAYLLH----RG
  .|..|. ..|..|....|. ...||  .. ... || .. ||. |  .| .  |.| ....|.|. .... ..||.||.||||..|.|||..    . 
dftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqleke

KFLKAQEALDFYGEVRtrdKKGVTIPSQRRYVYYYSY
. . ..||.... . |    ..|. |.| |..|.. .
lgvdleeavkllrsqR...pgavqnpeqyrflyeall
0045450 (Phosphotyrosine protein) phosphatases II 9-179 5e-31 104.0 In-house 54-300 (307) alignment 
Range on Protein: 9-179
Range on HMM: 54-300/307.0
VSRNKRRYQE-------------------------------------DGFDLDLTYI----------------------------------YPNIIAMGF
....|.||..                                     ||.||....|                                    ...|. .
enkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqyw

PAERLEGVYRNnidDVVRFLDSKHKNHYKIYNLCAERHyDTAKFNCRVAQYPF---EDHNPPQ-LELIKPFCEDLDQWLSED-DNHVAAIHCKAGKGRTG
| |. | .|.|   ..|..|. .|...|....|. ... |  ..  .| ....    ||. |. .| .  |.| ....|.|. .... ..||.||.||||
Pdegeeltygn...ftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtG

VMICAYLLHRGK-------FLKAQEALDFYGEVRtrdKKGVTIPSQRRYVYYYS
..|.|||. |.        .. ..||.... | |    ..|. |.| |..|.. 
tfiaaylmlrqlekegtlldvdlleavkllreqR...pgavqnpeqyrflyeal
0044763 (Phosphotyrosine protein) phosphatases II 9-185 2.8e-30 100.7 In-house 7-173 (178) alignment 
Range on Protein: 9-185
Range on HMM: 7-173/178.0
VSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAER-LEGVYRNNIDDVVRFLDSKHKNHYKiynlcaERHYDTAKFNCRVAQYPFEDHNPPQ-LELIKPFCE
|. ..... | .. .....|.|.......|... || .....|. .|.. . .. ...|      . .|.  ...... ..|..||..|. || .  |.|
vllsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflk......cdpywpeeagiqylhipipDhgvpdllehflefve

DLDQWLSeDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFlKAQEALDFYGEVRtrdKkGVTIPSQRRYVYYYSYLLKNH
 ....|. ..... ..||.||.||.|....|||... ..  ..||.... |.|     .|. |.|.|..|..   |.. 
fieeald.ekggpvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR...p.ivpnpgqlrqLyefelrllke
0046845 (Phosphotyrosine protein) phosphatases II 9-179 3.2e-26 87.8 In-house 27-270 (284) alignment 
Range on Protein: 9-179
Range on HMM: 27-270/284.0
VSRNKRRYQE-----------------------------DGFDLDLTYIYPNIIAMGFPAER-----------------------------LEGVYRNNI
  ..| ||.                              ||.||||||| ...||. .| .                                  |....
enlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwple

DDVVRF-------LDSKHKNHYKIYNLCAERHY-DTAKFNCRVAQYP-FEDHNPPQ-LELIKPFCEDLDQWLSE-DDNHVAAIHCKAGKGRTGVMICAYL
..|...       |. ..|..|....|. ...  .   . ... .|. . ||. |. .| .  |.......|.. ..... ..||.||.||||..|...|
gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdl

LHRG----K---FLKAQEALDFYGEVRtrdKKGVTIPSQRRYVYYYS
|..     .    . ..||. .. | |      |. ..| |.||.. 
lleqlekeglllgvdvleavkrlreqR...pgmvqtleqyrfvyeal
0041856 (Phosphotyrosine protein) phosphatases II 11-188 1.2e-35 118.2 In-house 2-176 (182) alignment 
Range on Protein: 11-188
Range on HMM: 2-176/182.0
RNKRRYQE---DGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYK-IYNLCaERHYDTAKFNC---RVAQYPFEDHNPPQLELIKP
..|.||..     ...||.|| .|......|| | .  ... ...| .||.  ...... | ||. |..|.  ....   .. ..|..||..| |. .  
ldknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelld

FCEDLDQwlsedDNHVAAIHCKAGKGRTGVMICAYLLHRGKfLKAQEALDFYGEVRtrdKKGVTIPSQRRYVYYYSYLLKNHLDY
|.|.  .     .... ..||.||.||||....|||... . . ..||.... . |    ..|..|.| ...... ..|. . ..
fieevle.....eggpvlVHCsaGvgRtgtlvaaylmkklg.vsleeavklvrsrR...pgmvitpnqyfflqlallellllkkt
subfamily_Tensin_pd Subfamily Tensin 14-197 5.1e-48 156.1 In-house 2-186 (189) alignment 
Range on Protein: 14-197
Range on HMM: 2-186/189.0
RRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLcAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLS
 || |. .|||||||   |||. |||| ||  ||.|. ||...|.|||...| ..|| .|..||  |.| .| .. . |.  | || .   |..||.||.
vryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWlk

EDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKK--GVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHK
.| ..|...||| ||||.||.. ||. .      |..||| .   |  |.|  |.| ||||||| |.| ||....      |..| 
adpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplflhy
0043147 (Phosphotyrosine protein) phosphatases II 14-185 3.4e-36 119.9 In-house 4-163 (172) alignment 
Range on Protein: 14-185
Range on HMM: 4-163/172.0
RRYQEDGFDLDLTYIYPNIIAMGFPaerlegvYRNNIDDVVRFLDSKHKNHykIYNLCaER---HYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQ
... .. ..|||.|| ...||. .|       .||...|..|.| ... .|  |.||. |.    ..  ......  .|..||..| |||.  |.| .|.
gsdyinasyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefide

WLSEDDNHVAAIHCKAGKGRTGVMICAYLLHrgKFLKAQEALDFYGEVRtrdKKGVTIPSQRRYVYYYSYLLKNH
.| ...... ..||.||.||||....|||..  . |...||.... | |    ..|..|||.|..||.. ||...
llalspggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR...pgavqnpsqyrflyyfeklllll
0046846 (Phosphotyrosine protein) phosphatases II 15-184 8.4e-41 135.0 In-house 2-174 (176) alignment 
Range on Protein: 15-184
Range on HMM: 2-174/176.0
RYQEDGFDLDLTYIYPNIIAMGFP-----------AERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAErhydTAKFNCRVAQYPFEDHNPPQLELIKP
|....|.||||.||..|.|....|           |. || .....|. ||.... ......|..|.. |      |..... ..|..||..|.|||.  
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgiqylhlpwpDhgvpdlellle

FCEDLDQWLSEDdnHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRdkKGVTIPSQRRYVYYYSYLLKN
..| ....|.|.  .. ..||.||.||||....||||...|.|...|||... |.| .  . |. |.|.|..|.. .||..
llefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl..gavqtpeQyrflyefellllk
0045098 (Phosphotyrosine protein) phosphatases II 18-186 1.8e-28 95.1 In-house 2-275 (278) alignment 
Range on Protein: 18-186
Range on HMM: 2-275/278.0
EDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNID------------------------------------------------------------------
|....|||.... .....|.| | ....|..|.|                                                                  
ealasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvel

-------------------------DVVRFlDSKHKNHYKIYNLCAERHYDTaKFNCRVAQY-PFEDHNPPQLE---LIKPFCEDLDQWLS---------
                         .. .. |  .. .....||. ||.... ... .. .| |..||..| |.    .  ..| ....|.         
grekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredle.srgvthlhylpwpdhgvpslpilksflellefirealkllaslllss

---EDDNHVAAIHCKAGKGRTGVMICAYLLHRG--KFLKAQEALDFYGEVRtrdKK-GVTIPSQRRYVYYYSYLLKNHL
   .|.... ..||.||.||||....|||. .   . . ..||.... . |       |....| |..|.. ..| ...
lllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR...pglavqnleqyrflyefllelllrg
0036282 (Phosphotyrosine protein) phosphatases II 20-185 1.5e-49 163.4 In-house 7-172 (174) alignment 
Range on Protein: 20-185
Range on HMM: 7-172/174.0
GFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHV
 ..|||.|| |..||...|.. .| .....| .||..|..|....||..|.. |...|  ...... ..|..||..| |. .  |.. ....||||....
aspldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggp

AAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNH
 ..||.||.||||....|||..||.. ....|||.. |.|.   ..|..|||.|..||.. ||...
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekllsgs
subfamily_Auxilin_pd Subfamily Auxilin 22-183 1.6e-42 138.0 In-house 8-165 (166) alignment 
Range on Protein: 22-183
Range on HMM: 8-165/166.0
DLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCaERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAA
|||..||   || | |||| .|  |.||||||  ||.|.|...|..|||  .|.|.|||.. || .. .  .. |.|| .   | .|..|| .| ..|  
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynls.qrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvv

IHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVrtRDKKGvTIPSQRRYVYYYSYLLK
.||| |.  ..|...|.|..   . ....|....     |  .|   ||..||..| . ||.
vhckDGraasavlvsallvfcrllsepesavrlfsvk..rlpig.lspsekryleyladlla
subfamily_CDC14_pd Subfamily CDC14 22-175 7.2e-12 39.8 In-house 169-316 (328) alignment 
Range on Protein: 22-175
Range on HMM: 169-316/328.0
DLDLTYIYPN-IIAMGFPAERL--EGVYRNNIDD-VVRFLdsKHKNHYKIYNLCaERHYDTAKFNCRV---AQYPFEDHNPPQLELIKPFCEDLDQWlse
  |...| |. ..|.  | ..   |  |. .  . ....   ...|  ..  |  .. ||  ||.          |.|   |. ...| | | ...    
nGDfnwivPdkflalagPhnkskledgyplhaPeklleyf..rknnvttvvrLn.kklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka...

ddNHVAAIHCKAGKGRTGVMICAYLLHRGKFlKAQEALDFYGEVRtrdkKGVTIPSQRRYV
  .  .|.||||| |||| .| .||... .|  |.||. .   .|     |. |  |....
..eGaiavhCkaGLGrtGtLiacylmkhyrf.taaeaiawlricr....PGsvigpqqkfl
0051082 (Phosphotyrosine protein) phosphatases II 23-180 5.9e-30 99.2 In-house 6-149 (151) alignment 
Range on Protein: 23-180
Range on HMM: 6-149/151.0
LDLTYIYPNIIAMGFPAErlegvyrnnidDVVRFLdsKHKNHYKIYNLCA--ERHYDTAKFNC---RVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDN
....|. ......|.| .           |....|  |. ... |.||.   || |..  ..    .| ..|..|. .|.|.|. ... .. ..| ...|
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

HVAAIHCKAGKGRTGVMICAYLLHRGkfLKAQEALDFYGEVRTrdkkGVTIPSQRRYVYYYSY
.. ..||.|||||||.....||...|  . ..|||..| . |.    ||..|.| ...... .
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkrp....gvvqpnqqflfqlfal
0038934 (Phosphotyrosine protein) phosphatases II 27-179 1.1e-39 131.5 In-house 15-167 (194) alignment 
Range on Protein: 27-179
Range on HMM: 15-167/194.0
YIYPNIIAMGFPAER-----LEGVYRNNIDDVVRFLDSKHKNHYKIYNLCA-ERHYDTAKFN---CRVAQYPFEDH-NPPQLELIKPFCEDLDQWLSEDD
.| ...||...|..      .|..||....|.||.|............|.  || ||. .|    ... ..||.|. ..|.||... |.. .|..|.|| 
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

NHVAAIHCKAGKGRTGVMICAYLLHRGKFlKAQEALDFYGEVRtrdkkgvtiPSQRRYVYYYS
..| |.|||||.||||....|||..| .. .|.||.... |.|         |.. ... |..
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekR.........pgaipnqdyle
0051429 (Phosphotyrosine protein) phosphatases II 28-182 1.1e-13 47.0 In-house 19-255 (272) alignment 
Range on Protein: 28-182
Range on HMM: 19-255/272.0
IYPN-IIAMGFP----AERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCaerhydtakFNCRVAQYPFEDHNPPQLELI---------------------
. |. ....|.|    |. ..  ....|. .| . .   ....| . .           ..|. ..|..|. .|. ...                     
vkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdryw.........pgirylhlpilddsaptilygalrvtllseellldyilrell

-------------------------------KPFCEDLDQwlseddNHVAAIHCKAGKGRTGVMICAYLLHRGKFLK---------AQEALDFYGEVRTR
                               . . | | .      ..   .||.|||.|||......|| .|  |           . ..... |.| .
ltlllsagearevmhlhytdwpdhgvpqeallellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyleeaveelraq

DKKGVTIPSQRRYVYYYS-------------------------------YLL
  . |  . |....| .                                || 
rpgavqteeqylflyeallellrsllsvraeyllaaldaideeyGsvegYLr
0049260 (Phosphotyrosine protein) phosphatases II 32-183 7.3e-36 118.5 In-house 4-150 (152) alignment 
Range on Protein: 32-183
Range on HMM: 4-150/152.0
IIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRT
..||.|..   .|...|...|..|.| . . ...  .. . |....  ..  .. ..|..||..|.|. . .|. .....| .|.... ..||.||.|||
gyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRt

GVMICAYLLHrgkflKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLK
|....|||..     .  ......  ||.. ...|. |.|.|..|... |||
gtlvaaylml.....lgvsleeavalvrekRpgavpnpgqlrflyefekllk
0048179 (Phosphotyrosine protein) phosphatases II 37-179 1.6e-29 97.9 In-house 3-141 (144) alignment 
Range on Protein: 37-179
Range on HMM: 3-141/144.0
FPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFN-CRVAQYPFEDHNPPQL-ELIKPFCEDLDQWLSedDNHVAAIHCKAGKGRTGVM
.|.| |.|.|.... .....   |. ... ..||. |....  ... ... ..|..||..|.| ||.  |.| ....|.  .... ..||.||.||||..
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtl

ICAYLLHRGKfLKAQEALDFYgevRTRDKKGVTIPSQRRYVYYYS
..|||... . | ..|||...   |.|   .|. |.|.|....|.
vaaylmkklg.lsleealalv...rsrrpgavpnpgqlrfLleye
0048076 (Phosphotyrosine protein) phosphatases II 37-182 1.7e-29 97.7 In-house 3-142 (145) alignment 
Range on Protein: 37-182
Range on HMM: 3-142/145.0
FPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTaKFNCRVAQYPFEDHNPPQL-ELIKPFCEDLDQWLSEDdnHVAAIHCKAGKGRTGVMI
.|.| |.|.|.... .....   |. ... ..||. |... . ...... ..|..||..|.| ||.  |.| ....|.|.  .. ..||.||.||||...
wpseilpglylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv

CAYLLHRGKfLKAQEALDFYGEVRtrdKKGVTIPSQRRYVYYYSYLL
.|||... . . ..|||... . |    ..|. |.|.|..|.. . |
aaylmlllg.vsleealelvrsqr...pgavpnpgqlrflyefelel
0036941 (Phosphotyrosine protein) phosphatases II 37-197 2.7e-21 71.6 In-house 124-291 (297) alignment 
Range on Protein: 37-197
Range on HMM: 124-291/297.0
FPAERLEGVYRNNIddVVRFLDSKH--KNHYKIYNLCAERHYDTAKFNCRVAQYP-FEDHNPPQ-LELIKPFCEDLDQWLSED-DNHVAAIHCKAGKGRT
.| |  | .. ...  .|..|. ..  ...|....|. . . .  .. ... .|.   ||..|.  . .  |.| ....|..  ....  .||.||.||.
wpleegesltygdf..tvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRs

GVMICAYLL----HRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHK
|..|.|.|.    ....  .    |... ..|..    |. ..| |..|.. . | .. .... .| ...
gtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvl
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 37-181 2.1e-08 28.6 In-house 119-264 (274) alignment 
Range on Protein: 37-181
Range on HMM: 119-264/274.0
FPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKfnCRVAQYP-FEDH-NPPQLELIKPFCEDLDQWLSEDDNHVAA--IHCKAGKGRTG
|| ..   .  . .|  ... . ...|.|.. .|  .   .. .  .    |. . ||  | . . .  .... ..  .|.....|.  .|| || ||||
fPdaedyeiserygdveikvekiverndysvrklvlkylerers..vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtG

VMICAYLLHRgkFLKAQEALDFYGEV-RTRDKKGVTIPSQRRYVYYYSYL
. | . .  |   |.... .|  . |   | ..|  . .. .| . .  |
cfiaisiavr..qlreeivvdvlkivcnlrldrGGmvqtseqyelihral
subfamily_CDKN3_pd Subfamily CDKN3 43-180 1.8e-06 21.7 In-house 64-193 (202) alignment 
Range on Protein: 43-180
Range on HMM: 64-193/202.0
EGVYRNNIDDVVRFLDSKHKNHYKIYNLCAErhYDTAKFncRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDdnHVAAIHCKAGKGRTGVMICAYLLHR
|..    ..||  .      ..|.. .|  .  | .| .   |  ||. |   |.      . |.|   | .   . . .||  | ||. ..|   ||  
eelksqgvedvfvlctrgelskyrvrrlldl..yqqagl..ivhhypiadglvpdiasclkileelrinlkay..rktlvhcygglgrsslviaclllyl

GKFLKAQEALDFYGEVRTrdKKGVTIPSQRRYVYYYSY
  ... ..|.|   ...    . .    |  |.  .  
ddtiepkdaidklrdlkg..sraiqtvkqynylsefrd
subfamily_PTPMT1_pd Subfamily PTPMT1 47-160 3.1e-09 31.5 In-house 44-149 (171) alignment 
Range on Protein: 47-160
Range on HMM: 44-149/171.0
RNNIDDVVRFldskhKNHYKIYNLCaERHYDTAKFNCRVAQYPFEDHN-PPQLELIKPFCEDLDQWLSEDdnHVAAIHCKAGKGRTGVMICAYLLHRGKf
 .|.  || .     .. |..  |. .   .  | .    |..  |.   |.|| ..   | ...  |.   .   .|||||.||.. .. .||... | 
kenvkavvsl.....neeyelkala.nsteewkklgveqlqlatvDfteapdleklekgvefiekvaskg..krvYvHCkaGrgRsatlvacylmkkek.

LKAQEALDFYGEVRT
|. .|||..  . | 
lspeeAlkalkkkRk
subfamily_DSP11_pd Subfamily DSP11 51-160 6.7e-12 39.6 In-house 44-158 (178) alignment 
Range on Protein: 51-160
Range on HMM: 44-158/178.0
DDVVRFLDSKHKNHYKIYNLC-AERHYDTAKFNCRVAQYP---FEDHNPPQLELIKPFCEDLDQWL--SEDDNHVAAIHCKAGKGRTGVMICAYLLHRGK
.|... |..|.|.   . .|  ..|.|.. ... .  .|       |. |. ||.| |.| ....|  ..|.... ..||  |  ||| .|| ||...  
kdLleklqeknkklGLvidltntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidveg

FlKAQEALDFYGEVRT
. ....|.. . |.| 
y.epedaieafeearG
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 52-187 3.9e-07 24.3 In-house 128-260 (267) alignment 
Range on Protein: 52-187
Range on HMM: 128-260/267.0
DVVRFLDSKHKNHYKIYNLCAERHYDTAkFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAY-LLHRGKFLKAQE
 .| .   | .| |.|  |  . . ..| .|  .  |   . |  .   .||.   | .   |. |.   ..|..| ||.| .. ..  |.| |     .
ltvehslekeendyqiitlelkfknesa.hnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsd

ALDFYGEVRtrDKKGVTIPSQRRYVYYYSYLlKNHLD
  ||  ..|  ...   . .. ||.| .  |  .. .
ifdflrkir..sqriglvdtkeryiyihell.aeyae
0051299 (Phosphotyrosine protein) phosphatases II 53-178 2.2e-23 78.6 In-house 150-281 (288) alignment 
Range on Protein: 53-178
Range on HMM: 150-281/288.0
VVRFLDSKHKNHYKIYNLCAERH----YDTAKFNCRVAQYP-FEDHNPPQ-LELIKPFCEDLDQWLSeDDNHVAAIHCKAGKGRTGVMICAYLL-HRGKF
.|..|. .....|....|. ...    .|  ...... .|. . ||. |. .||.  |.......|. ..... ..||.||.||||..|...|| .. ..
tvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlek

LKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYY
 .  ..|...  .|..    |. |.| |.||..
eggvdvleavkrlreqRpgmvqtpeqyrfvyea
0047943 (Phosphotyrosine protein) phosphatases II 53-178 3.3e-23 78.0 In-house 138-267 (273) alignment 
Range on Protein: 53-178
Range on HMM: 138-267/273.0
VVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYP-FEDHNPP-QLELIKPFCEDLDQWLSED-DNHVAAIHCKAGKGRTGVMICAYLLH----RGKF
 |..|. ..|..|....|. ... .  .. ... .|. . ||. | .|| .  |.|.....|... .|.. ..||.||.||||..|...||.    ... 
tvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekegg

LKAQEALDFYGEVRTRdkkGVTIPSQRRYVYYY
. . ||. .. . |     .|. |.|.|..|..
vdvleavkllrsqRpg...mvqtpeqyrflyea
0050432 (Phosphotyrosine protein) phosphatases II 53-178 5.4e-18 60.8 In-house 169-294 (308) alignment 
Range on Protein: 53-178
Range on HMM: 169-294/308.0
VVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPF-EDHNPPQ-LELIKPFCEDLDQWLsedDNHVAAIHCKAGKGRTGVMICAYLL----HRGKFL
.|..|. .....|....|. . . |   . ... .|.  .||. |. .| .  |.| ....|   .... ..||.|| ||||..|...||    .... .
tvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggv

KAQEALDFYGEVRTRdkkGVTIPSQRRYVYYY
 ..||. .  | |      |. |.| ...|..
dvfeavkklReqRpg...mvqtpeqylflyra
subfamily_PRL_pd Subfamily PRL 53-162 2.4e-13 44.4 In-house 23-130 (151) alignment 
Range on Protein: 53-162
Range on HMM: 23-130/151.0
VVRFLDSKHKNHYKIYNLCAERHYDTAKFN---CRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGkfLKAQ
. .| .. .|.. |    . |  |||.|..    .| ...|.| ..|  |... . | | .  .|. ... |.|| || ||. |...  |.  |  .| .
lekfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaG..mkye

EALDFygeVRTRD
.|..|   .|.. 
davef...irekr
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 53-182 1e-07 26.3 In-house 149-280 (319) alignment 
Range on Protein: 53-182
Range on HMM: 149-280/319.0
VVRFLDSKHKNHYKIYNLCAERHYDTAKFnCRVAQYPFE---DHN-PPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYL-LHRgkfLK
.|  .. .....| | .|. ... .  .   .| .. ..   ||. | .. ..  . ... .  .. ..    .|| || ||||  |     | |   .|
ivtleeeeeledyiirklklnkkssevet.RevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamler...vk

AQEALDFYGEVR-TRDKKGVTIPSQRRYVYYYSYLL
 ...|| .  |. .| .. . .  .  | . |  ||
eegvlDvfstvsrlRtqRnimvqrpeqYkfiyeall
subfamily_Ptp69D_pd Subfamily Ptp69D 53-184 1.5e-06 22.6 In-house 149-285 (307) alignment 
Range on Protein: 53-184
Range on HMM: 149-285/307.0
VVRFLDSKHKNHYKIYNLCAERHYDTA---KFNCRVAQYPFED---HNPP-QLELIKPFCEDLDQWLSEDdNHVAAIHCKAGKGRTGVMICAYLLHRGkf
.|.. .......| | .|   .  ...   . . .| || .      . | . . .  . | . .  . . .    .||.|| ||.|....  .|     
lvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln.rsPivvhCsaGvgrsgifvaldsllqq..

LKAQEALDFYGEVRT-RDKKGVTIPSQRRYVYYYSYLLKN
||| . .| .  |.  | .. . . | . ||. |  ||. 
lkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 54-182 8.5e-09 29.9 In-house 148-277 (318) alignment 
Range on Protein: 54-182
Range on HMM: 148-277/318.0
VRFLDSKHKNHYKIYNLCAERHYDTAkfNCRVAQYPF---EDHNPPQ--LELIKpFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAY-LLHRgkfLK
|   .... ..| . ..  .|.   .  .  | || .    |.. |.   .|.. .  . ...  . .... ..|| || ||||| |    ||.|   .|
velkeevelsdyvlrefkvtrteeee..srqvrqyhytsWpdegvpesgaslld.lvrqvskaqqksgagpivvhCsaGvGrtGvfiavdiller...ik

AQEALDFYGEVRT-RDKKGVTIPSQRRYVYYYSYLL
|.. .| .. |.. |... . .  . .|.. |  ||
aealvDvfqtvkqlreqrnlmvqtedqyefiydvll
subfamily_PTPRB_pd Subfamily PTPRB 54-182 1.9e-07 25.4 In-house 154-282 (293) alignment 
Range on Protein: 54-182
Range on HMM: 154-282/293.0
VRFLDSKHKNHYKIYNLCAERHYDTAKFNcRVAQYPFEDHNPP-QLELIKPFCEDLDQWL-SEDDNHVAAIHCKAGKGRTGVMICAYLLHrgKFLKAQEA
| .. ....... | .|  |.. .. | . .     . ||. | . . .  |.. ..... .. ...   .|| || ||||. |.   |   . .. .. 
vtlvaeeeledwvirelkiekekeerkvr.qyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrll..qaieeedy

LDFYGEVR-TRDKKGVTIPSQRRYVYYYSYLL
.| .| |   | .. . . ....|.. .. .|
vdifgivaelReeRnllvqtekqYifihqcvl
subfamily_PTPRD_pd Subfamily PTPRD 54-182 3.9e-06 20.8 In-house 150-278 (564) alignment 
Range on Protein: 54-182
Range on HMM: 150-278/564.0
VRFLDSKHKNHYKIYNLCAERHYDTAKfnCRVAQYPFE---DHNPPQL-ELIKPFCEDLDQWLsEDDNHVAAIHCKAGKGRTGVMICA-YLLHRgkfLKA
| . .......| | ..  ... .  .    | |. |    ||. |.  . .  . ..  ..  |.|..   .|| || ||||. |   ..| |   .|.
Vtleeeeeladyeirtfklkkkksses..reVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfividamler...ike

QEALDFYGEVR-TRDKKGVTIPSQRRYVYYYSYLL
.. .| |. |.  | .. . . ..  |.. .. .|
ektvDiyqyvkalrkqRnamVqteeQYiFiheail
DSPc_SM00195 56-178 5.8e-06 21.2 In-house 132-255 (263) alignment 
Range on Protein: 56-178
Range on HMM: 132-255/263.0
FLDSKHKN-HYKIYNLCAERHYDTAKFNCRVAQYP-FEDHNPP-QLELIKPFCEDLDQWLSEDdNHVAAIHCKAGKGRTGVMICAYLLHrgKFLKAQEAL
. . ..|. ......|  . . .  ...... ||   .||. | . . .  . . .... |.  ..   .||.|| ||||..... ..   . |.... .
lvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiil..skleeekkv

DFYGEVR-TRDKKGVTIPSQRRYVYYY
|.   |.  |...   . ..  | . |
difeivkelRkqRpgmvqtleqYlfiy
PTPc_SM00194 56-178 5.8e-06 21.2 In-house 132-255 (263) alignment 
Range on Protein: 56-178
Range on HMM: 132-255/263.0
FLDSKHKN-HYKIYNLCAERHYDTAKFNCRVAQYP-FEDHNPP-QLELIKPFCEDLDQWLSEDdNHVAAIHCKAGKGRTGVMICAYLLHrgKFLKAQEAL
. . ..|. ......|  . . .  ...... ||   .||. | . . .  . . .... |.  ..   .||.|| ||||..... ..   . |.... .
lvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiil..skleeekkv

DFYGEVR-TRDKKGVTIPSQRRYVYYY
|.   |.  |...   . ..  | . |
difeivkelRkqRpgmvqtleqYlfiy
Y_phosphatase Protein-tyrosine phosphatase 61-181 3.7e-06 21.9 Pfam-A 112-233 (235) alignment 
Range on Protein: 61-181
Range on HMM: 112-233/235.0
HKNHYKIYNLCAERHYDT-AKFNCRVAQYP-FEDHNPP-QLELIKPFCEDLDQWLsEDDNHVAAIHCKAGKGRTGVMICAYLLHRGkfLKAQEALDFYGE
....| ...|  . . .  .|.  .. .|   .||. | . . .  ..... ..  |....   .||.|| ||||..... .| .   |.|.| .| .  
dekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq..leaeeevdvlqi

VR-TRDKKGVTIPSQRRYVYYYSYL
|.  | ..   . |   |.. |  .
vkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 61-181 3.7e-06 21.9 In-house 112-233 (235) alignment 
Range on Protein: 61-181
Range on HMM: 112-233/235.0
HKNHYKIYNLCAERHYDT-AKFNCRVAQYP-FEDHNPP-QLELIKPFCEDLDQWLsEDDNHVAAIHCKAGKGRTGVMICAYLLHRGkfLKAQEALDFYGE
....| ...|  . . .  .|.  .. .|   .||. | . . .  ..... ..  |....   .||.|| ||||..... .| .   |.|.| .| .  
dekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleq..leaeeevdvlqi

VR-TRDKKGVTIPSQRRYVYYYSYL
|.  | ..   . |   |.. |  .
vkelRkqRpgmvqsleqYiflykai
subfamily_RNGTT_pd Subfamily RNGTT 72-160 1.9e-10 34.7 In-house 64-155 (189) alignment 
Range on Protein: 72-160
Range on HMM: 64-155/189.0
AERHYDTAKF---NCRVAQYPFEDHNP-PQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFlKAQEALDFYGEVRT
 .|.||. ..   ...  .   . .   |. | .| | . .... ..  ..| ..||. |  ||| .|..||... .. ....|.. . . | 
tsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedw.sveaavalFakaRp
DSPc Dual specificity phosphatase, catalytic domain 80-159 1.9e-09 32.5 Pfam-A 42-114 (133) alignment 
Range on Protein: 80-159
Range on HMM: 42-114/133.0
KFNCRVAQyPFEDHNPPQLELIKPFCEDLdqwlsEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFlKAQEALDFYGEVR
.... | .   |.   ..|| .. | |..     |....  ..||.||  |.. .|.|||. . .. ...||..|  | |
ylripved.etetkiskeleeavefieka.....eqkgkkvlVHCqaGisRSatliiaYlmktknl.slneAyefvkerr
DSPc Dual specificity phosphatase, catalytic domain 80-159 1.9e-09 32.5 In-house 42-114 (133) alignment 
Range on Protein: 80-159
Range on HMM: 42-114/133.0
KFNCRVAQyPFEDHNPPQLELIKPFCEDLdqwlsEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFlKAQEALDFYGEVR
.... | .   |.   ..|| .. | |..     |....  ..||.||  |.. .|.|||. . .. ...||..|  | |
ylripved.etetkiskeleeavefieka.....eqkgkkvlVHCqaGisRSatliiaYlmktknl.slneAyefvkerr
subfamily_DSP23_pd Subfamily DSP23 81-178 6.4e-10 33.9 In-house 50-141 (148) alignment 
Range on Protein: 81-178
Range on HMM: 50-141/148.0
FNCRVAQYPFEDHNPPQLELIKPFCEDLDQwlSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKfLKAQEALdfyGEVRTRDKKGVTIPSQRRYVYYY
 |  . .   .|. || || .. | . ...  .|. |   ..||  |.|||| |.  ||..  | | | ||.    ||| .    |    | . |. |
pnltlvrlriddyhppaleqvvefvrvvee..aeekneavsvhcllgrgrtgtmlacylvkerk.laaaeai...aevrrlrpgsvetveqeklvrdy
subfamily_PTPDC1_pd Subfamily PTPDC1 82-175 3.8e-11 37.8 In-house 82-168 (182) alignment 
Range on Protein: 82-175
Range on HMM: 82-168/182.0
NCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDdnhVAAIHCKAGKGRTGVMICAYLLHRGKfLKAQEALDFygeVRTRDKKGVTIPSQRRYV
.  | .....|.. . || |      ... |.|.     |.|| ||.|||||.|..||..  . |.|..|...   || .  | .   .| . |
giyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyakr.ltaekaikl...vrskrpksiqtreqvelv
0048567 (Phosphotyrosine protein) phosphatases II 88-182 2.4e-11 38.3 In-house 43-138 (157) alignment 
Range on Protein: 88-182
Range on HMM: 43-138/157.0
YPFEDHNPPQLELIKPFCEDLDQWLS--EDDNHVAAIHCKAGK---GRTGVMICAYLLHRGKFlkaqEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLL
 .| |. |. | ..  |.  |...|.  |  ... |.|||||    |||...|..||. . .|     . .... .|  . . |  . .  ....|...|
dfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgf....tpeeaiaplrivrpgsvpfrdasyllslynltl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 90-183 2.6e-06 21.7 In-house 185-277 (288) alignment 
Range on Protein: 90-183
Range on HMM: 185-277/288.0
FEDHNPPQLEliKPFCEDLDQWL--SEDDNHVAAIHCKAGKGRTGVMICAYLLHrgKFLKAQEALDFYGEV-RTRDKKGVTIPSQRRYVYYYSYLLK
. ||. |. .  .|. | |.|    ...|     .|| || ||||. | .  |   . ..... .|  | | . | .. . .  ...|.. |. ||.
WpdhgvPesk..apllellrqvkvanqadtgpiivhCsaGvGrtgtFialdali..daveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
PTPc_motif_SM00404 91-159 4.9e-08 28.0 In-house 59-121 (140) alignment 
Range on Protein: 91-159
Range on HMM: 59-121/140.0
EDHNPPQLELIKPFCEDLdqwlsEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKfLKAQEALDFYGEVR
.|.  ..|. .. | |.      |....   .||.||  |.. .|.|||... . |...||..|. | |
kdklskyldkvldfiena.....ekkggkvlVHCqaGvSRSatliiaYlmryrq.lslaeayefvkerR
subfamily_PTPRK_pd Subfamily PTPRK 91-183 2.9e-06 21.3 In-house 184-275 (314) alignment 
Range on Protein: 91-183
Range on HMM: 184-275/314.0
EDHNPP-QLELIKPFCEDLDQWLSEdDNHVAAIHCKAGKGRTGVMICAYLLHrgKFLKAQEALDFYGEVRT-RDKKGVTIPSQRRYVYYYSYLLK
 ||. | . . .  .   ....  | ..    .|| || ||||. |    .     .. .. .| .  |.| |..|   .  . .|.. |  .| 
pdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivl..dmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
PTPc_DSPc_SM00012 92-182 1.2e-11 40.1 In-house 12-104 (105) alignment 
Range on Protein: 92-182
Range on HMM: 12-104/105.0
DHN-PPQLELIKPFCEDLDQWLSEDD-NHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLL
||. | . . |  ........ .. . ..   .||.|| ||||.......|..    . .|   |    . |...  .. ... |.. | .||
dhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyrall
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 104-181 4.5e-06 21.0 In-house 203-279 (305) alignment 
Range on Protein: 104-181
Range on HMM: 203-279/305.0
FCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYL-LHRgkfLKAQEALDFYGEVRT-RDKKGVTIPSQRRYVYYYSYL
. ... .  ..| .    .|| || ||||| |.  . | |   ||. | .|... ... | |.   . .. .||. .  |
likrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialer...lkkEevvdvfevlkqlRskrmkmvqtldqYvflhdal
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 114-190 8.7e-06 19.8 In-house 207-281 (315) alignment 
Range on Protein: 114-190
Range on HMM: 207-281/315.0
EDDNHVAAIHCKAGKGRTGVMICAYLLHrgKFLKAQEALDFYGEVRT-RDKKGVTIPSQRRYVYYYSYLLKnHLDYRP
. ...   .|| || |||||.| .      . .| ....| .  |.. |.|.   . .. .| . |  .|. .| .| 
gkkefsllvhcsaGvGrtGvvisidevv..aqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle.dllwrn
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 115-186 6e-06 21.0 In-house 184-256 (284) alignment 
Range on Protein: 115-186
Range on HMM: 184-256/284.0
DDNHV--AAIHCKAGKGRTGVMICAYLLHrgKFLKAQEALDFYGEVRT-RDKKGVTIPSQRRYVYYYSYLLKNHL
  ||     .|| || |||||.|.   |   . .| .. .| |  ||  |...   . .  .| . || ||..||
kenhranivvhcsagvgrtgvyivldvll..drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 116-186 6.7e-06 20.6 In-house 221-292 (319) alignment 
Range on Protein: 116-186
Range on HMM: 221-292/319.0
DNHV--AAIHCKAGKGRTGVMICAYLLHrgKFLKAQEALDFYGEVRT-RDKKGVTIPSQRRYVYYYSYLLKNHL
 ||     .|| || ||||| |    |   . .| .. .| |  ||  |...   . .  .| . || ||..||
enhranivvhcsaGvGrtGvyivldvll..drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 188-349 1.4e-48 155.4 Pfam-A 1-134 (134) alignment 
Range on Protein: 188-349
Range on HMM: 1-134/134.0
YRPVALLFHKMMFETIPMF-SGGTCNPQFVVCQLKVKI---YSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGp
| |..| ......|.||.| ..|.|.|.. |.. |.|.   ..|.. .|.|..| .....|..|||.||..|||.||..|. ||.|.|..|.||.||.. 
ynpkrlelksiilegiPnfktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFiek.

eetsekvengslcdqeidsicsieradndkEYLVLTLTKNDLDKANKDKaNRYFSPNFKVKLYFTK
                              .. ||||.||.||||.||| ...||.||||.|.|.|
..............................nqnvltlpkneLDkalkdk.dkkfsknfkvelvfek