Gene TNS2 in Homo sapiens

Synonym: C1-TEN, C1TEN, TNS2, TENC1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily Tensin
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP065_AA protein Get Run
HsapP065_AA_116-318 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
C1_1 Phorbol esters/diacylglycerol binding domain (C1 domain) 42-90 9.6e-09 24.9 Pfam-A 1-51 (53) alignment 
Range on Protein: 42-90
Range on HMM: 1-51/53.0
HSFREKVFrKKPPVCAVCKVTI---DGTGVSCRVCKVATHRKCEAKVTSACQ
| .... | |.|  |..|.  .     .|..|. |..  | ||  ||.. |.
Hhwvhrnf.kqptfCkhCgkflwgkgkqglkCswCqllvHkkCfekvpkecg
0043336 (Phosphotyrosine protein) phosphatases II 117-272 7.1e-13 44.1 In-house 45-252 (278) alignment 
Range on Protein: 117-272
Range on HMM: 45-252/278.0
NHSKQRS--TLPRSFSLDPLMERRWDLDLTYV----------TERILAAAFPARPDEQRHRGHLRE----------------------------------
|..| |.   ||  .|.  |     |||..|.          .....|. .|    .  ..  ..|                                  
nkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdf

LAHVLQSKHRDKYLLFNLSEK--RHDLTRLNPKVQDFGWPELHAP-PLDKLCSICKAMETWLSaDPQHVVVLYCKGNKGKLGVIVSAYMHY----SKISA
  ..|  .| | | ...|  .  ... .|    .. .|||. ..| .|. |....||. ..|. |....|.  |.. .|. |... .|. .    .    
tvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggv

GADQALATL
 ...|...|
dleeavkel
0042113 (Phosphotyrosine protein) phosphatases II 119-274 6.3e-14 47.4 In-house 11-220 (245) alignment 
Range on Protein: 119-274
Range on HMM: 11-220/245.0
SKQRS--TLPRSFSLDPLMERRWDLDLTYV----------TERILAAAFPARPDEQRHRGHLRELA----------------------------------
.| |.   ||  ...  |..  .|||..|.          |....|...|.. . . .   |.||                                   
dknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdft

-HVLQSKHRDKYLLFNLSEK--RHDLTRLNPKVQDFGWPELHAPP-LDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMHY----SKISAG
 ..|  .| |.| ...|. .  ..| .| .  .. ..||. ..|. |. |..........|..|....|.  |.. .|  |... ||. .    .     
vtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvs

ADQALATLTM
...|.. | .
leeavkelrs
subfamily_Tensin_pd Subfamily Tensin 133-319 1.9e-97 317.3 In-house 3-189 (189) alignment 
Range on Protein: 133-319
Range on HMM: 3-189/189.0
PLMERRWDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNLSEKRHDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLSAD
...|...||||||.||||.|..|||...|...| .|...|..|.|||.||||.|||||||.|...||.||.|||||.|.||.|.|||||||....||.||
ryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnlsekrydisklnkkvldfGWPdllaPsleklcsicksldsWlkad

PQHVVVLYCKGNKGKLGVIVSAYMHYSKISAGADQALATLTMRKFCEDKVATELQPSQRRYISYFSGLLSGSIRMNSSPLFLHYVLI
||.|||..|||.||..||.|||||.||||||.||.||....|..|..||...|.|||||||..||||||||.|..||||||||||..
pqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrflddklsgetqPsqrryveyfsglLsgkiklnssplflhyvil
0040438 (Phosphotyrosine protein) phosphatases II 133-275 3.4e-07 25.3 In-house 61-254 (317) alignment 
Range on Protein: 133-275
Range on HMM: 61-254/317.0
PLMERRWDLDLTYV----------TERILAAAFPArpdE---QRHRGHLREL-----------------------------------AHVLQSKHRDKYL
 |     |||..|.          . ...|. .|    .     .   . |.                                    ..|. .. . . 
kLsplggdldsdYInAsyvdgpnlkrkfIatqgPl...pntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagit

LFNLSE--KRHDLTRLNPKVQDFGWPELHAPP-LDKLCSICKAMETWLSaDPQHVVVLYCKGNKGKLGVIVSAYMH-----YSKiSAGADQALATLTMR
|..|    .... .| .   .  |||. ..|| .| | ....|....|. ||...|.  |.. .|. |... ||.      . .    ...|...| ..
lrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreq
0046846 (Phosphotyrosine protein) phosphatases II 134-300 6.7e-17 57.3 In-house 3-171 (176) alignment 
Range on Protein: 134-300
Range on HMM: 3-171/176.0
LMERRWDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSkhrDKYLLFNLSEKR-----------HDLTRLNPKVQDFGWPELHAPPLDKLCSIC
|... .||||.|....... ..|.  ..  .| .   |.....    . ....|| | .           ..|..|. ... ..||. ..|.|. |....
lrllgldldldyinanlilgsrpiatqgplprtladflemlkel...gitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllell

KAMETWLSADpqHVVVLYCKGNKGKLGVIVSAYMHYSKISAGADQALATLTMRKFCedkvATELQPSQRRYISYFSGL
......|...  ..|.  |.. .|  |..| ||. ...    ...|||.. ....          |.|.|.. .|  |
efirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl....gavqtpeQyrflyefell
0044763 (Phosphotyrosine protein) phosphatases II 135-276 1.8e-07 26.5 In-house 15-151 (178) alignment 
Range on Protein: 135-276
Range on HMM: 15-151/178.0
MERRWDLDLTYVTERILAAAFPArpdeqrhrghlreLAHVLQSKHRDKYLLFNLS---------EKRHDLTRLNPKVQDFGWPELHAPP-LDKLCSICKA
.||   ...............|.              ... . |  .  .. ||.         . . .... . ... ...|  ..|. |. .  ....
lersdyinaseilpglylgslpp.............addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvef

METWLSADPqHVVVLYCKGNKGKLGVIVSAYMHYSKiSAGADQALATLTMRK
.|..|. .. ..|. .|.  .|  |..| ||. ..  .  ...|.. . .|.
ieealdekg.gpvlVHCsaGvgRsgtlvaaylmkkl.glsleeaielvrerR
subfamily_PTEN_pd Subfamily PTEN 136-302 3.8e-40 132.8 In-house 15-180 (184) alignment 
Range on Protein: 136-302
Range on HMM: 15-180/184.0
ERRWDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNL-SEKRHDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQ
|  .||||.|.||.|.| ..||   |. .| .|... ..|..||.|.| ..|| ||...| .... .|. ..  . ..|||. | .|.. .|.||..|..
edgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleeivediekwleedkk

HVVVLYCKGNKGKLGVIVSAYMHYSKISAGADQALATLTMRKFCEDKVATelQPSQRRYISYFSGLLS
.|||..||  ||. ||...||. .|..   |..||.  .  .. ..|  |   ||||||..|.. ||.
nvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknkkgvt..iPsqrRYveYyeklle
0039614 (Phosphotyrosine protein) phosphatases II 136-276 1.8e-15 52.7 In-house 78-268 (297) alignment 
Range on Protein: 136-276
Range on HMM: 78-268/297.0
ERRWDLDLTYV-----------TERILAAAFPARPDEQRHRGHLRELA---------------------------------HVLQSKHRDKYLLFNLSEK
|. .|||..|.           | ...|. .|       .   ..|.                                  ..|. .|.| | ...|. .
edgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevt

RHDLTRLNPKVQDFGWPELHAPP-LDKLCSICKAMETWLSAD-PQHVVVLYCKGNKGKLGVIVSAYMHY----SKISAGADQALATLTMRK
... .|    .| .|||. ..|| |. |..........|... ....|.  |.. .|. |... ||. .    ..    ...|...| ...
nngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR
PTEN_1 137-303 2.6e-33 110.5 In-house 16-194 (196) alignment 
Range on Protein: 137-303
Range on HMM: 16-194/196.0
RRWDLDLTYVTERILAAA-FPARP-----DEQRHRGHLRELAHVLQSKHRDK-YLLFNLSEKRHD-------LTRLNPKVQ--DFGWPELHAPPLDKLCS
.  .|||||.|.||.|   .|.||     ||.. ||.|...|  |.... |. .|..||||....        .. . .|.  .|...  .||.|..|. 
ptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfd

ICKAMETWLSADP-QHVVVLYCKGNKGKLGVIVSAYMHYSKIsAGADQALATLTMRKFCEDKVatelQPSQRRYISYFSGLLSG
||| .. ||..|| ..||. .||. .|  |..| ||. |..    ||.||. .  .  .  .     .|||.|.. ||. ||..
icksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn....spsqerlleyfaellae
0037934 (Phosphotyrosine protein) phosphatases II 137-296 2.6e-16 55.4 In-house 33-236 (243) alignment 
Range on Protein: 137-296
Range on HMM: 33-236/243.0
RRWDLDLTYVTERILAAAFPARPDEQR----HRGHLRELA---------------------------------HVLQSKHRDKYLLFNLSEKR---HDLT
  ....|.|||.|. |  .|     ..    .   | ||                                  ..|...| |.| ...|. ..    |||
dyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddlt

RLNPKVQDFGWPELHAPP--------LDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMHYSKISAGADQALATLTMRKFCedkvATELQP
||. ... ..||. ..|.        ||......... ..| .|....|.. |.. .|. |... ||....... ....|...| .....         |
rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpg....kavqtp

SQRRYISY
||.|.. .
sqyrflye
subfamily_Auxilin_pd Subfamily Auxilin 138-302 8.9e-40 129.1 In-house 6-165 (166) alignment 
Range on Protein: 138-302
Range on HMM: 6-165/166.0
RWDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNLSEKRHDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVV
. |||..|.| ||.  .|||   |  .. .. .... |.|.| .|||..|||.. .. ..|. .| . |||. .||.|..| ..|. . .|| .||..||
kndlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynlsqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvv

VLYCKGNKGKLGVIVSAYMHYSKISAGADQALATLTMRKFCEDkvateLQPSQRRYISYFSGLLS
|. ||  .   .|.|||.. . ..   ...|.  .....  ..     |.||..||..|...||.
vvhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig.....lspsekryleyladlla
subfamily_VSP_pd Subfamily VSP 139-299 9.8e-33 107.8 In-house 32-196 (212) alignment 
Range on Protein: 139-299
Range on HMM: 32-196/212.0
WDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNL-SEKRHDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVV
.|||||||||||.|..||.   .. .|  ..|.|  |. ||||.| ..|| ||. .| . .| .|.     .   | |..| ...| .. ||..|...|.
fdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkriliddhnvpkleellvftkevkewlekdlknvl

VLYCKGNKGKLGVIVSAYMHYSKISAGADQALATLTMRKFCED---KVATELQPSQRRYISYFSG
...||| ||. | || |.. .|.|   |...|  .. |.  ..   |      |||.||..|.  
aihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleq
0036282 (Phosphotyrosine protein) phosphatases II 139-305 3.3e-26 87.4 In-house 8-173 (174) alignment 
Range on Protein: 139-305
Range on HMM: 8-173/174.0
WDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNLS-EKRHDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVV
 .|||.|.|.|..| ..|..  |. .. ... .  .|..|....|. .|.  |.|.||.||. ......||  ..|.|..|....|..|..|| ||...|
spldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpv

VLYCKGNKGKLGVIVSAYMHYSKISAGADQALATLTMRKFCedKVATELQPSQRRYISYFSGLLSGSI
.  |.. .|  |..| ||...  .  ....||... .....  .      |||.|.. ||. |||||.
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlq..rpgmvqtpsQyrflyyfekllsgsl
0041856 (Phosphotyrosine protein) phosphatases II 139-297 2.4e-14 48.8 In-house 15-166 (182) alignment 
Range on Protein: 139-297
Range on HMM: 15-166/182.0
WDLDLTYVTERILAAAFPARPDEQRHRGHLRELAHVLQSKHRDKY-LLFNLSEKRHDLTRLNP---KVQDFGWPELHAPPLDKLCSICKAMETwlsadPQ
...||.|....... ..||.  .  .. .|...|. |.  .. .. .. ||.| ... ..|.    ......||  ..|.||.|........      ..
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfieevle.....eg

HVVVLYCKGNKGKLGVIVSAYMHYSKiSAGADQALATLTMRKFCedkvaTELQPSQRRYISYF
..|.  |.. .|. |..| ||..... . ....|.... .|...        .|.| ... ..
gpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrRpg.....mvitpnqyfflqla
0043147 (Phosphotyrosine protein) phosphatases II 139-300 4.5e-11 38.3 In-house 11-159 (172) alignment 
Range on Protein: 139-300
Range on HMM: 11-159/172.0
WDLDLTYVTERILAAAFParpdeqrHRGHLRELAHVLQSKHRDKylLFNLSEK---RHDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQH
 .|||.|.. |..|  .|        | .| .  . |.... .   ..|| |    . .|.||. ... ..||  ..|.|. | .... ....|  .|..
syldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspgg

VVVLYCKGNKGKLGVIVSAYMHYskISAGADQALATLTMRKfcedkVATELQPSQRRYISYFSGL
.|.  |.. .|  |..| ||. .   .  ...|.|.. ...           |||.|.. ||. |
pvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR.....pgavqnpsqyrflyyfekl
0040439 (Phosphotyrosine protein) phosphatases II 141-272 2e-08 29.6 In-house 47-221 (249) alignment 
Range on Protein: 141-272
Range on HMM: 47-221/249.0
LDLTYVTERILAAAFPARPDEQRHRGHLRE-----------------------------------LAHVLQSKHRDKYLLFNLSEK--RHDLTRLNPKVQ
.|..|.. |..|. .|       ..  |.|                                     ..|. .. |.| ...|  .   .. .|    .|
idgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiq

DFGWPELHAP-PLDKLCSICKAMETWLSAD-PQHVVVLYCKGNKGKLGVIVSAYMHY------SKISagADQALATL
 ..||. ..|  .. |.....|....|... ....|.  |.. .|. |... ||. .       ...  ...|...|
ytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvd..leeavkll
0051082 (Phosphotyrosine protein) phosphatases II 141-276 2.6e-07 25.9 In-house 6-132 (151) alignment 
Range on Protein: 141-276
Range on HMM: 6-132/151.0
LDLTYVTERILAAAFPARpdeqrhrghlrelAHVLQSKHRDKYLLFNLSEKR---HDLTRLNP---KVQDFGWPELHAPPLDKLCSICKAMETWLSADPQ
....|||..... ..|               ... . |. . .  .|| ..    ..  .|.    .| .. ..  ..|.|. .  .....  .| ....
infsyvtgglyrsggpla.............dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

HVVVLYCKGNKGKLGVIVSAYMHYSKisAGADQALATLTMRK
..|. .|.. ||  |..| .|... .    ...||. . .. 
gpvlvHCsaGkgRTGtlvalylmllg..vsleealeeyrlkr
0038934 (Phosphotyrosine protein) phosphatases II 145-276 5.2e-16 54.3 In-house 15-156 (194) alignment 
Range on Protein: 145-276
Range on HMM: 15-156/194.0
YVTERILAAAFPARP-----DEQRHRGHLRELAHVLQSKHRDKYLLFNLSEK-----RHDLTRLNPKVQDFGWPE-LHAPPLDKLCSICKAMETWLSADP
..|.|..| ..|.        |. .| ... | ..|...... .|. .|..      . ...... .. .. .|.  ..|.|. |..........|..||
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

QHVVVLYCKGNKGKLGVIVSAYMHYSkISAGADQALATLTMRK
..||.  ||. .|. |..| ||. |.     |..|.|......
ggvvaVHCkaGlgRtGtlvaaYLiyr.lgmsaeeAialfrekR
0045450 (Phosphotyrosine protein) phosphatases II 147-273 8e-08 27.8 In-house 145-280 (307) alignment 
Range on Protein: 147-273
Range on HMM: 145-280/307.0
TERILAAAFPARPDEQRHRGhlrELAHVLQSKHRDKYLLFNLSEKRHDLTRLNPKVQDFGW---PELHAPP-LDKLCSICKAMETWLSAD-PQHVVVLYC
. .. |  .|   .|. ..       ..|  .| |.| ...|  ...| |    .|. | .   |. ..|| .. |..........|... ....|.  |
grekcaqywPdegeeltygn...ftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHC

KGNKGKLGVIVSAYMHYSKIS-------AGADQALATLT
.. .|  |... ||. .. .          ...|...| 
saGvgRtGtfiaaylmlrqlekegtlldvdlleavkllr
0048179 (Phosphotyrosine protein) phosphatases II 155-297 1.3e-10 36.7 In-house 3-140 (144) alignment 
Range on Protein: 155-297
Range on HMM: 3-140/144.0
FPARPDEQRHRGHLRELAHVLQSKHRDKYLLFNLSEKRHDLTRLNP--KVQDFGWPELHAPPL-DKLCSICKAMETWLSadPQHVVVLYCKGNKGKLGVI
.|.. ... ..|.|  . .. . |. . ....||.|...     ..  ... ..||  ..|.| . |.......|..|.  . ..|. .|.. .|  |..
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtl

VSAYMHYsKISAGADQALATLTMRKFcedkvATELQPSQRRYISYF
| ||. . |    ...||| . .| .          |.|.|.. ..
vaaylmk.klglsleealalvrsrrp.....gavpnpgqlrfLley
0048076 (Phosphotyrosine protein) phosphatases II 156-297 7.1e-12 40.7 In-house 4-138 (145) alignment 
Range on Protein: 156-297
Range on HMM: 4-138/145.0
PARPDEQRHRGHLRELAHVLQSKHRDKYLLFNLSEKRHDLTRLNPKVQDFGWPELHAPPL-DKLCSICKAMETWLSADpqHVVVLYCKGNKGKLGVIVSA
|.. ...  .| |    .. . |. . ....||.  ...|.||. ... ..||  ..|.| . |.......|..|...  ..|. .|.  .|  |..| |
pseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlvaa

YMHYSkISAGADQALATLTMRKFCedkvaTELQPSQRRYISYF
|. ..  .  ...||. . .. ..         |.|.|.. .|
ylmll.lgvsleealelvrsqrpg.....avpnpgqlrflyef
0049772 (Phosphotyrosine protein) phosphatases II 172-282 1.2e-08 30.5 In-house 167-260 (314) alignment 
Range on Protein: 172-282
Range on HMM: 167-260/314.0
AhvlqskhrdkyllfnlSEK--RHDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWlsaDPQHVVVLYCKGNKGKLGV-IVSAYMHYSKiSAGADQA
                 .|   .....||. |. .. .|  .||.|. . ......|..   |....|.  ||. ||  |. .| ||. .      ...|
k................eelydpelferlgikylripvpDgsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll.gvsleea

LATLTMRKFCEDKV
|. . .. ..  . 
ledvrlkRpinpnp
0046845 (Phosphotyrosine protein) phosphatases II 172-266 5.6e-08 28.0 In-house 137-243 (284) alignment 
Range on Protein: 172-266
Range on HMM: 137-243/284.0
AHVLQSKHRDKYLLFNLSEKR---HDLTRLNPKVQDFGWPELHAPP-LDKLCSICKAMETWLSA-DPQHVVVLYCKGNKGKLGVIVSAYMHYSKISAGA-
 ..|  ...| | ...|. ..    . .|     . ..||. ..|| .. | .........|.. ......|  |.. .|. |... ... .. . ..  
vtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekegl

------D
       
llgvdvl
0045098 (Phosphotyrosine protein) phosphatases II 174-268 4.2e-08 28.4 In-house 130-242 (278) alignment 
Range on Protein: 174-268
Range on HMM: 130-242/278.0
VLQSKHRDKYLLFNLSEKRHDLTRLNPKVQDF-GWPELHAPPLD---KLCSICKAMETWLS------------ADPQHVVVLYCKGNKGKLGVIVSAYMH
||.  .  ..|. ||. .|.||. .. .. .. .||. ..|.|.    . .... .. .|.             |....|.  |.  .|  |..| ||. 
vlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylm

YSKISAG--ADQA
.. .  |  ...|
lelleggvdllea
0047943 (Phosphotyrosine protein) phosphatases II 175-261 7e-07 24.5 In-house 142-232 (273) alignment 
Range on Protein: 175-261
Range on HMM: 142-232/273.0
LQSKHRDKYLLFNLSEKR--HDLTRLNPKVQDFGWPELHAP-PLDKLCSICKAMETWLSAD-PQHVVVLYCKGNKGKLGVIVSAYMHYSKI
|  ...| | ...|  ..   . .|    .. .|||. ..|  |. | .........|.|.  ...||  |.. .|. |... ... .. .
lseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldql
0051299 (Phosphotyrosine protein) phosphatases II 175-262 1.6e-06 23.3 In-house 154-247 (288) alignment 
Range on Protein: 175-262
Range on HMM: 154-247/288.0
LQSKHRDKYLLFNLSEK------RHDLTRLNPKVQDFGWPELHAPP-LDKLCSICKAMETWLSaDPQHVVVLYCKGNKGKLGVIVSAYMHYSKIS
|  .. |.| ...|  .       .. .|     . ..||. ..|. .. | ...... ..|. .....||  |.  .|. |... ... .. . 
lseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqle
0049260 (Phosphotyrosine protein) phosphatases II 185-300 2.5e-08 29.2 In-house 40-148 (152) alignment 
Range on Protein: 185-300
Range on HMM: 40-148/152.0
LFNLSEKRHDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLYCKGNKGKLGVIVSAYMHYskISAGADQALATLTMRKfcedkVAT
| .|.|. .. .   .... . ||  ..|.|. |  ..  .  .|  |....|.  |.. .|  |..| ||. .      ...|.| . ...        
ltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml..lgvsleeavalvrekR.....pga

ELQPSQRRYISYFSGL
   |.|.|.. .|..|
vpnpgqlrflyefekl
subfamily_PTPDC1_pd Subfamily PTPDC1 193-274 1.8e-06 22.5 In-house 76-153 (182) alignment 
Range on Protein: 193-274
Range on HMM: 76-153/182.0
HDLTRLNPKVQDFGWPELHAPPLDKLCSICKAMETWLSADpqhVVVLYCKGNKGKLGVIVSAYMHYSKiSAGADQALATLTM
 .|.. .  |  |||..  ...|...  | | ..  |. .    | ..|   .|. ||....|. |.| .  |..|. ..  
ealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg...kvavhChaGlGrtGvliacylvyak.rltaekaiklvrs
PTPc_DSPc_SM00012 201-318 4.3e-08 28.7 In-house 4-103 (105) alignment 
Range on Protein: 201-318
Range on HMM: 4-103/105.0
KVQDFGWPELHAPP-LDKLCSICKAMETWLSADP-QHVVVLYCKGNKGKLGVIVSAYMHYSKISAGAdqalatltmrkfcedkvateLQPSQRRYISYFS
...  |||. ..|   |.......|.... ..   .. ||. |.   |. |..| ...........                      .... ...... 
hyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket....................kevdifqivkelr

GLLSGSIRMNSSPLFLHYVL
   .|.....   |||. .|
kqRpgmvqteeqylflyral
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 307-433 8.8e-27 84.9 Pfam-A 1-133 (134) alignment 
Range on Protein: 307-433
Range on HMM: 1-133/134.0
MNSSPLFLHYVLIPMLPAFEPGTGFQPFLKIYQSMQLV-YTSGVYHIAGPGPQQLCISLEP-ALLLKGDVMVTCYHKGGRGTDRTLVFRVQFHTCTIH--
.|...|.|. . .  .|.|. . |..|..|.|. .. | .... |.      .. .|  ||  |...|||.| ..||. .   .  .|||.|.|. |.  
ynpkrlelksiilegiPnfktrggckpkvkvyngkkkvfkelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFiekn

GPQLTFPKDQLDEAWTD--ERFPFQASVEFVFS
  .||.||..||.|. |  ..|. . .||.||.
qnvltlpkneLDkalkdkdkkfsknfkvelvfe
SH2 SH2 domain 1159-1251 4.9e-12 36.4 Pfam-A 1-77 (77) alignment 
Range on Protein: 1159-1251
Range on HMM: 1-77/77.0
WYKPHLSRDQAIALLKD-KDPGAFLIRDSHSFQGAYGLALKVATpppsaqpwkgdpveqLVRHFLIETGPKG-VKIKGcpsEPYFGSLSALVSQH
||  ..||..|  ||.. | .|.||.|.|.|..| | |...                   |.|. |..  .| . | .   . .| ||. ||. .
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddg...............kvkhyriqslengkyyite...nekfsslqeLvehY
PTB Phosphotyrosine-binding domain 1294-1427 5.6e-45 141.4 Pfam-A 1-129 (131) alignment 
Range on Protein: 1294-1427
Range on HMM: 1-129/131.0
ACSVLYLTSVETESLTGPQAVAR--ASSAALSCSPRPTPAVVHFKVSAQGITLTDNQRKLFFrRHYPVNSITFSSTDPQDRRWTNpdgttskIFGFVAKK
...|..||.|...||||..||..  |....|......... |..||||||.|||||.|| .. ..||.||..........||...       ....||..
qyrVehLttvdldsltgveavedaiaklklldakgkvwaqevllkVsaqgvtLtDnerKeel.esyplnsvkkckavleerryes.......llalvare

PGSPWENVcHLFA--ELDPDQPAGAIVTFITKVLLGQR
|.| .||| |||.  ||...|.| .|.....||.||..
pesskenv.hlFqcdeleaeqiaediekalskvklgkk