Gene TPTE in Homo sapiens

Synonym: CT44, PTEN2, TPTE

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily VSP
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP068_AA protein Get Run
HsapP068_AA_185-413 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
PKD_channel Polycystin cation channel 129-178 8.4e-07 14.0 Pfam-A 217-265 (426) alignment 
Range on Protein: 129-178
Range on HMM: 217-265/426.0
ISLAIALFFLMDVLLRVFVERrQQYFSDLFNILDTAIIVILLLVDVVYIF
| |...|.|.....|..  |. ..|.....|.|| ||.|. ..| |..|.
iflvfvlyfvveevlkirkeg.asylrsvwnlldlaivvlsvvvivlail
Ion_trans Ion transport protein 131-220 1.5e-10 29.0 Pfam-A 4-88 (200) alignment 
Range on Protein: 131-220
Range on HMM: 4-88/200.0
LAIALFFLMDVLLRVFVER--RQQYFSDLFNILDTAIiVILLLVDVVYIFFDIKLLrniprwTHLLRLLRLIILLRIFHLFHQKRQLEKLIR
... ..|....||.... .  .. |..|..|||| .. |...||.... ... .        ..||..|||. .||.. |.   ..|..|..
yvftviftlemllkiialgfkkftylrdpwnilDflv.vlpslvslilrllnkesa......egllsvlrllrvlRllrlisrieglrtllg
0043336 (Phosphotyrosine protein) phosphatases II 186-398 6.7e-30 99.9 In-house 7-273 (278) alignment 
Range on Protein: 186-398
Range on HMM: 7-273/278.0
NIPRWTHLLRLLRLIILLRIFHLFHQKRQLEKLIRRRVSENKRRY-------------TRDGFDLDLTYV----------TERIIAMSFPSSGRQSFYRN
 . .. .||. |. ..||  ..| ..|    .  ..  . .|.||             . .|.|||..|.          ....||...|...    ...
llkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwr

PIKE----------------------------------VVRFLDKKHRNHYRVYNLCSER-AYDPKHFHNRVVRIMIDDHNVP-TLHQMVVFTKEVNEWM
 ..|                                  .|..|. .| ..| |..|. ..  ..........  . . ||.|| .| ... | |.|.|..
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

AqDLENIVAIHCKGGTDRTGTMVCAFLIA----SEICSTAKESLYYFGERRtdkthsekFQGVETPSQKRYVAYFA
. | .. |..||..| .||||.....|.     .| . .. | . .. |.|        .. |.|||| |.. ...
e.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR........pgavqtpsqyrflyeal
0040438 (Phosphotyrosine protein) phosphatases II 198-413 3.4e-26 87.7 In-house 17-287 (317) alignment 
Range on Protein: 198-413
Range on HMM: 17-287/317.0
RLIILLRIFHLFHQKRQLEKLIRRRVSENKRRY-------------TRDGFDLDLTYV----------TERIIAMSFPSSG-----RQSFYRNPIKEVVR
  ..|   ..| ..|    .  .. .. .|.||             . .|.|||..|.          . ..||...| ..      . .... .. .|.
ftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivm

FLDKK------------------------------HRNHYRVYNLCSERAYDPKHFHNRVVRIMI-DDHNVP-TLHQMVVFTKEVNEWMAqDLENIVAIH
. . .                              . ... ...|. |  .|........   .  .||.|| .. ... | ..|.|... | .. |..|
LteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVH

CKGGTDRTGTMVCAFLIA----SEICSTAKESLYYFGERRtdkthsekFQGVETPSQKRYVAYFAQVKHLYNWNLPPRRI
|..| .||||...|.|.      | . ...| .... |.|         ..|.||.| |.. ....  ......|.|   
CsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqR........pgavqtpeqyrflydalleylkrkltlepase
0039614 (Phosphotyrosine protein) phosphatases II 201-406 1.6e-32 108.6 In-house 27-293 (297) alignment 
Range on Protein: 201-406
Range on HMM: 27-293/297.0
ILLRIFHLFHQKR-------QlEKLIRRRVSENKRRYT--------------RDGFDLDLTYV-----------TERIIAMSFPSSG-----RQSFYRNP
 .. . .|. .            .  .. .. .|.||.               ||.|||..|.           | ..||...|...      . .... 
kansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvweqg

IKEVV----------------------------RFLDKKHRNHYRVYNLCSERaYDPKHFHNRVVRIMIDDHNVP-TLHQMVVFTKEVNEWMAQD-LENI
.. .|                            ..|. .|...| |..|. .. ... ......  . . ||.|| .| ..  | ..|.|..|..  .. 
vtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpkggp

VAIHCKGGTDRTGTMVCAFLIA----SEICSTAKESLYYFGERRtdkthsekFQGVETPSQKRYVAYFAQVKHLYNW
|..||..| .||||...|.|.     .| . ...| . .. |.|         ..|.|||| |.. ....   ....
vlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR........pgavqtpsqyrflydallellkrkl
subfamily_VSP_pd Subfamily VSP 204-414 6.9e-127 415.5 In-house 1-211 (212) alignment 
Range on Protein: 204-414
Range on HMM: 1-211/212.0
RIFHLFHQKRQLEKLIRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIM
||..|..|||.|||..||.|||||||||.|||||||||||||||||||||||.||.|||||.||.||||.|||.||.|.|||||||||.|.|.|||.||.
rilrlltqkrklekaarrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkril

IDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKTHSEKFQGVETPSQKRYVAYFAQVKHL
|||||||.|....||||||.||...||.|..|||||||..||||.|||.|.||||..||||||.||||||||||..||||||.||||||||.|..|||..
iddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktk

YNWNLPPRRIL
||..|||...|
ynrklppaktl
subfamily_PTEN_pd Subfamily PTEN 219-400 9e-67 219.6 In-house 2-178 (184) alignment 
Range on Protein: 219-400
Range on HMM: 2-178/184.0
IRRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVF
.|. ||..|.|...||.||||.|.||.||||..|. . .. ||| ...||.||.|||..||..|||.|||.|| |.|..||  . .|||| |.|. .  .
lrkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleei

TKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKThsekfQGVETPSQKRYVAYFAQV
 .....|...| .|.|..||| |  |||....|.|. | ....|.|.| .| | || ..     .||  |||.||| |. ..
vediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknk.....kgvtiPsqrRYveYyekl
PTEN_1 220-401 1.9e-44 146.8 In-house 3-192 (196) alignment 
Range on Protein: 220-401
Range on HMM: 3-192/196.0
RRRVSENKRRYTRDGFDLDLTYVTERIIAMS-FPSSG-----RQSFYRNPIKEVVRFLDKKHRNH-YRVYNLCSERA-----YDPKH-FHNRVV--RIMI
| . . .|... .....|||||.|.|||||. .|| .      .. ||...|.|...|| .. .. . |.||..|..     ||... |...|   ...|
rlskrsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpi

DDHNVPTLHQMVVFTKEVNEWMAQDL-ENIVAIHCKGGTDRTGTMVCAFLIASEIcSTAKESLYYFGERRTD-KTHsekfqgveTPSQKRYVAYFAQVK
.||..|.|...  . |.. ||. .|  .|.|..|||.|  |.||.|.|.|....  .||.| | .. |.|.    .        .|||.|.. |||. .
eDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn........spsqerlleyfaell
0042113 (Phosphotyrosine protein) phosphatases II 220-398 5.9e-28 93.3 In-house 5-239 (245) alignment 
Range on Protein: 220-398
Range on HMM: 5-239/245.0
RRRVSENKRRY-------------TRDGFDLDLTYV----------TERIIAMSFPSSGRQS-----FYRNPIKEVV-----------------------
.. .. .|.||             . ||.|||..|.          |...||...|...        .... |. .|                       
llpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesl

-------RFLDKKHRNHYRVYNLCSER-AYDPKHFHNRVVRIMIDDHNVPT-LHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIA----
       ..|. .| ..| |..|. ..  .|........ .. ..||.||. | ... | ..|....|.| .. |..||..| .||||...|.|..    
tygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqle

SEICSTAKESLYYFGERRtdkthsekFQGVETPSQKRYVAYFA
.| . .. | .... ..|         . |.|||| |.. ...
kelgvsleeavkelrsqR........pgavqtpsqyrflyeal
0045450 (Phosphotyrosine protein) phosphatases II 220-398 3e-24 81.8 In-house 51-300 (307) alignment 
Range on Protein: 220-398
Range on HMM: 51-300/307.0
RRRVSENKRRYTR-------------------------------------DGFDLDLTYV----------------------------------TERIIA
.. .. .|.||.                                      ||.||.....                                  . ...|
llpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekca

MSFPSSGRQSFYRNpikEVVRFLDKKHRNHYRVYNLCSERaYDPKHFHNRVVRIMI---DDHNVP-TLHQMVVFTKEVNEWMAQD-LENIVAIHCKGGTD
. .|..| .  |.|    .|..|...| ..| |..|. .. .|..... .|  .      ||.|| .. ... | .||.......  .. |..||..| .
qywPdegeeltygn...ftvtllseehldgytvrtlevtd.ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvg

RTGTMVCAFLIASEIC-------STAKESLYYFGERRtdkthsekFQGVETPSQKRYVAYFA
||||...|.|. . .         .. | . .. |.|         ..|..|.| |.. ...
RtGtfiaaylmlrqlekegtlldvdlleavkllreqR........pgavqnpeqyrflyeal
0044763 (Phosphotyrosine protein) phosphatases II 220-404 1.2e-22 75.8 In-house 4-173 (178) alignment 
Range on Protein: 220-404
Range on HMM: 4-173/178.0
RRRVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSG-RQSFYRNPIKEVVRFLDKKHRNHYRvynlcsERAYDPKHFHNRVVRIMIDDHNVPT-LHQMVV
| ||. ......  .. .............|.|..  .. .... |. .|.. . ......       . .|.|. .. ....| |.||.||. | ..  
rtrvllsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflk......cdpywpeeagiqylhipipDhgvpdllehfle

FTKEVNEWM-AQDleNIVAIHCKGGTDRTGTMVCAFLIASEICsTAKESLYYFGERRtdkthsekFqGVETPSQKRYVAYFAQVKHLY
|.. ..|..  ..  . |..||. | .|.||.|.|.|. .  . .. | . .. |||        . .|..|.| |.. .|..  . .
fvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkklgl.sleeaielvrerR........p.ivpnpgqlrqLyefelrllke
0037934 (Phosphotyrosine protein) phosphatases II 222-398 1.7e-30 101.8 In-house 8-238 (243) alignment 
Range on Protein: 222-398
Range on HMM: 8-238/243.0
RVSENKRRYT--------------RDGFDLDLTYVTERIIAMSFPSSG---------RQSFYRNPIKEVV----------------------------RF
 .. .|.||.               | ....|.|||.|.||...| ..          . .... |. .|                            ..
penlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtl

LDKKHRNHYRVYNLCSER--AYDPKHFHNRVVRIMIDDHNVPT-LHQMVVFTKEVNEWMAQ-------DLENIVAIHCKGGTDRTGTMVCAFLIASEICS
|. .| ..| |..|. |.  ..|..... .. .. . ||.||.   ... | .||.|.. .       | .. |..||..| .||||...|.|. . .. 
lseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgv

TAKESLYYFGERRTDkthsekfQGVETPSQKRYVAYFA
.. | . .. |.|          .|.|||| |.. ...
dleeavkllreqRpg.......kavqtpsqyrflyeal
0040439 (Phosphotyrosine protein) phosphatases II 223-399 2.5e-25 85.0 In-house 10-243 (249) alignment 
Range on Protein: 223-399
Range on HMM: 10-243/249.0
VSENKRRYT---------------RDGFD--------LDLTYVTERIIAMSFPSSGRQSFYRNPIKE---------------------------------
.. .|.||.               ...|.        .|..|.. |.||...| ..  . ... ..|                                 
enkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleyg

--VVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRI-MIDDHNVP-TLHQMVVFTKEVNEWMAQD-LENIVAIHCKGGTDRTGTMVCAFLIA----SE
  .|..|. .. ..| |..|. .. ||..... .....  . ||.|| .. ... | ..|.......  .. |..||..| .||||...|.|.      |
dftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqleke

ICSTAKESLYYFGERRtdkthsekFQGVETPSQKRYVAYFAQ
 . ...| . .. ..|        ...|..|.| |.. ....
lgvdleeavkllrsqR........pgavqnpeqyrflyeall
0046845 (Phosphotyrosine protein) phosphatases II 226-401 4.2e-24 80.8 In-house 30-273 (284) alignment 
Range on Protein: 226-401
Range on HMM: 30-273/284.0
NKRRYTR-----------------------------DGFDLDLTYVTERIIAMSFPSSG-----------------------------RQSFYRNPIKEV
.| ||.                              ||.||||||.. ..||...| ..                               ..|.....||
sknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplegev

VRF-------LDKKHRNHYRVYNLCSERA--YDPKHFHNRVVRIMIDDHNVPT-LHQMVVFTKEVNEWMAQ-DLENIVAIHCKGGTDRTGTMVCAFLIAS
...       |.......| |..|. ..    .. ....    . . ||.||. . ... | ..|.|.. . . .. ...||..|  ||||.... |. .
ltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllle

EI-------CSTAKESLYYFGERRtdkthsekFQGVETPSQKRYVAYFAQVK
 .       . .. | .... |.|        .. |.|..| |.| ....  
qlekeglllgvdvleavkrlreqR........pgmvqtleqyrfvyealley
0041856 (Phosphotyrosine protein) phosphatases II 227-410 3.6e-30 100.3 In-house 4-179 (182) alignment 
Range on Protein: 227-410
Range on HMM: 4-179/182.0
KRRYT---RDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYR-VYNLCsERAYDPKHFHN---RVVRIMIDDHNVPTLHQMVVFT
|.||.   .  ...||.|........|.|..    ........| .||.  ...... . ||. |. |.|.....   ..... ..||.||.|.... | 
knrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelldfi

KEVNEwmaqdLENIVAIHCKGGTDRTGTMVCAFLIASEiCSTAKESLYYFGERRtdkthsekFQGVETPSQKRYVAYFAQVKHLYNWNLPP
.||.|      .. |..||..| .||||.|.|.|. .    .. | . .. .||        ...|.||.| ... ...  ..|.... |.
eevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrR........pgmvitpnqyfflqlallellllkktrpk
subfamily_Tensin_pd Subfamily Tensin 228-400 3.4e-50 163.2 In-house 2-170 (189) alignment 
Range on Protein: 228-400
Range on HMM: 2-170/189.0
RRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLcSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMA
 ||... .||||||.||||||.|||..| .. ||. .|.|...|..||...|.|.|| ||. || ......|. .   |.  |.| ..    |....|. 
vryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWlk

QDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRtdkTHSEKFQGVETPSQKRYVAYFAQV
.|..|.|..||||| .|.| .| |..  |.|...|...|  |  .|      .| .|.  |||.||| || ..
adpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkr...flddklsgetqPsqrryveyfsgl
0043147 (Phosphotyrosine protein) phosphatases II 228-403 2.8e-30 100.7 In-house 4-162 (172) alignment 
Range on Protein: 228-403
Range on HMM: 4-162/172.0
RRYTRDGFDLDLTYVTERIIAMSFPssgrqsfYRNPIKEVVRFLDKKHRNHyrVYNLCsER---AYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNE
...  . ..|||.|.. |.||. .|       .||.. ...|.| ... .|  ..||. |.   ... ...  .. .. ..||.||.| ..  | . ..|
gsdyinasyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefide

WMAQDLENIVAIHCKGGTDRTGTMVCAFLIAseICSTAKESLYYFGERRtdkthsekFQGVETPSQKRYVAYFAQVKHL
..|.. .. |..||..| .||||.|.|.|.    . .. | . .. |.|        ...|..||| |.. ||..  .|
llalspggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR........pgavqnpsqyrflyyfekllll
0046846 (Phosphotyrosine protein) phosphatases II 229-399 3.5e-30 100.4 In-house 2-170 (176) alignment 
Range on Protein: 229-399
Range on HMM: 2-170/176.0
RYTRDGFDLDLTYVTERIIAMSFPSSGR-----------QSFYRNPIKEVVRFLDKKHRNHYRVYNLCSEraydPKHFHNRVVRIMIDDHNVPTLHQMVV
|....|.||||.|.....|..|.|  .            . .... |. ||.... .. ......|...|     . .. .. .. ..||.||.| ..  
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgiqylhlpwpDhgvpdlellle

FTKEVNEWMAQDleNIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDkthsekfQGVETPSQKRYVAYFAQ
. ....|.  ..  . |..||..|  ||||.|.|.|. .| . .. | |... |.|         . |.||.| |.. .|..
llefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl.......gavqtpeQyrflyefel
0036282 (Phosphotyrosine protein) phosphatases II 234-398 1.5e-39 130.9 In-house 7-166 (174) alignment 
Range on Protein: 234-398
Range on HMM: 7-166/174.0
GFDLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENI
 ..|||.|.|.|.||...| .  . .... |. ||..|. |....|...|...|. .|..... ........||.||.|...  | |.|.|....| .. 
aspldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggp

VAIHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTdkthsEKFQGVETPSQKRYVAYFA
|..||..| .||||.|.|.|.   ..... . |... |.|.      . ..|.|||| |.. || 
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRl.....qrpgmvqtpsQyrflyyfe
0045098 (Phosphotyrosine protein) phosphatases II 234-404 6.6e-22 73.6 In-house 4-274 (278) alignment 
Range on Protein: 234-404
Range on HMM: 4-274/278.0
GFDLDLTYVTERIIAMSFPSSGRQSFYRNPIK--------------------------------------------------------------------
...|||.. .|.......||.   . |.....                                                                    
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

-----------------------EVVRFlDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLH---QMVVFTKEVNEWMA------------
                       .. .. |. .  ...|.||..||....... . .  . ..||.||.|.   ..  ......|...            
ekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslll

QDLENIVAIHCKGGTDRTGTMVCAFLIASEI--CSTAKESLYYFGERRtdkthsekFQ-GVETPSQKRYVAYFAQVKHLY
.| .. |..||. | .||||.|.|.|. . .    .. | . .. ..|         .  |....| |.. .|..  .|.
ldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR........pglavqnleqyrflyefllelllr
subfamily_Auxilin_pd Subfamily Auxilin 236-400 2.3e-43 140.8 In-house 8-163 (166) alignment 
Range on Protein: 236-400
Range on HMM: 8-163/166.0
DLDLTYVTERIIAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLcSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVA
|||..|.| ||| ||||. | .| |.| |..|  ||. .| ..| |||| |.| |.......||| . .  ...| |...|  ....  |. .| .|.| 
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvv

IHCKGGTDRTGTMVCAFLIASEICSTAKESLYYFGERRTDKThsekfqgvETPSQKRYVAYFAQV
.||| |   ....|.|.|.  .. |....... |  .|. .          .||.|||. |.|..
vhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig........lspsekryleyladl
0051082 (Phosphotyrosine protein) phosphatases II 237-397 2.8e-22 74.4 In-house 6-147 (151) alignment 
Range on Protein: 237-397
Range on HMM: 6-147/151.0
LDLTYVTERIIAMSFPSSgrqsfyrnpikEVVRFLdkKHRNHYRVYNLCS--ERAYDPKHFHN---RVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLE
....|||........|..           .....|  |. ... ..||.|  ||.|.|. ...   .|..| |.|. .|.| ..  . .|. |..... .
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NIVAIHCKGGTDRTGTMVCAFLIAseICSTAKESLYYFGERRTdkthsekfqGVETPSQKRYVAYF
. |..||..| .||||.|...|..     .. | | .. ..|.         || .|.| ... .|
gpvlvHCsaGkgRTGtlvalylml..lgvsleealeeyrlkrp.........gvvqpnqqflfqlf
0038934 (Phosphotyrosine protein) phosphatases II 241-379 6.3e-37 122.5 In-house 15-162 (194) alignment 
Range on Protein: 241-379
Range on HMM: 15-162/194.0
YVTERIIAMSFPSSG-----RQSFYRNPIKEVVRFLDKKHRNHYRVYNLC-SERAYDPKHFHN---RVVRIMIDD-HNVPTLHQMVVFTKEVNEWMAQDL
..|.|.||...|.||      ...||.... .||.|. ...... |..|. .|| |||..|..   ....... | ..||.| ..  | . |.|....| 
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

ENIVAIHCKGGTDRTGTMVCAFLIASEICsTAKESLYYFGERRTDKTHS
...||.|||.|  ||||.|.|.|| .  . .|.|....| |.| .   .
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekRpgaipn
subfamily_PTPDC1_pd Subfamily PTPDC1 241-379 6.2e-09 30.5 In-house 17-161 (182) alignment 
Range on Protein: 241-379
Range on HMM: 17-161/182.0
YVTERIIAMSFPSSGR-------QSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVV---RIMIDDHNVPTLHQMVVFTKEVNEWMAQDl
.||| |.|.. ||.         . |  . || |. . .|    .    .  |  .||.... .. .    . ..|..|..|....   | |.  . .. 
WvtedilalarpsqeaideyklldkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg.

enIVAIHCKGGTDRTGTMVCAFLIASEICsTAKESLYYFGERRTDKTHS
   ||.||  |  ||| .....|. ..   ||....    ..|..  ..
..kvavhChaGlGrtGvliacylvyakrl.taekaiklvrskrpksiqt
0036941 (Phosphotyrosine protein) phosphatases II 244-401 6.9e-16 53.9 In-house 104-276 (297) alignment 
Range on Protein: 244-401
Range on HMM: 104-276/297.0
ERIIAMS-------------FPSSGRQSFYRNPIkeVVRFLDKKH--RNHYRVYNLCSER-AYDPKHFHNRVVRIMIDDHNVPT-LHQMVVFTKEVNEWM
. |. ..             .|.  ..|.. ...  .|..|. ..   ..| ...|. .   ...... .    . ..||.||.   ... | ..|....
tvIvmltelvelgrekcaqywpleegesltygdf..tvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

AQD-LENIVAIHCKGGTDRTGTMVCAFLIASEIC---STAKESLYYFgerrTDKTHSEKFQGVETPSQKRYVAYFAQVK
..   .. | .||..|  |.||...|.|. . ..    . . ... .      |  . ... |.|..| |.. .. .  
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdilea....vkklReqRpgavqtleqyrflyeallel
0049772 (Phosphotyrosine protein) phosphatases II 245-408 1.1e-18 63.5 In-house 122-284 (314) alignment 
Range on Protein: 245-408
Range on HMM: 122-284/314.0
RIIAM---------------------SFPSSGRQsfyrnpikevvRFLDK------KhrnhyrvynlcsERAYDPKHFHNRVVRI---MIDDHNVPTLHQ
|.| |                       . .|..            ...       |            |. |||..| .....     ..|...|.| .
rdivmsrdevladelsrLdaAlgKtpllildgng...........neptaadlellk............eelydpelferlgikylripvpDgsaplled

MVVFTKEVNEWmaqDLENIVAIHCKGGTDRTGT-MVCAFLIASEiCSTAKESLYYFGERRTdktHSEKFQGVetPSQKRYVAYFAQVKHLYNWNL
.  | . ..|.   | .. |..|||.| .|||| .|.|.|.      ...| | .. ..|.    . ..  .  .....|. .. ........ .
fdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll.gvsleealedvrlkRp...inpnpgfi..eqleqyefilealleylkflk
0049260 (Phosphotyrosine protein) phosphatases II 247-399 7.3e-28 92.6 In-house 5-147 (152) alignment 
Range on Protein: 247-399
Range on HMM: 5-147/152.0
IAMSFPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTG
.||.|.  . |  ..|......|.| . . ... ... ..|....  ... .. .. ..||.||.|.|.. |  .. |..|.| .. |..||..| .|||
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtg

TMVCAFLIAseICSTAKESLYYFGERRtdkthsekFQGVETPSQKRYVAYFAQ
|.|.|.|.      ...| . .. |.|         ..|..|.| |.. .|..
tlvaaylml..lgvsleeavalvrekR........pgavpnpgqlrflyefek
subfamily_CDC14_pd Subfamily CDC14 248-366 5.5e-08 27.0 In-house 182-297 (328) alignment 
Range on Protein: 248-366
Range on HMM: 182-297/328.0
AMSF---------------PSSGRQSFYRNPIKEVVRfLDKKhrnhyrvynlcserAYDPKHFHNRVV---RIMIDDHNVPTLHQMVVFTKEVNEWmaqd
|..                | .  . | .| ...||| |.||               || |.| .  .    ..  |  .|. . .  |.. ...     
alagPhnkskledgyplhaPeklleyfrknnvttvvr.Lnkk..............lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka....

lENIVAIHCKGGTDRTGTMVCAFLIAsEICSTAKESL
 |  .|.||| |  ||||.. ..|.  .   ||.|..
.eGaiavhCkaGLGrtGtLiacylmk.hyrftaaeai
0048076 (Phosphotyrosine protein) phosphatases II 251-399 7.1e-22 73.1 In-house 3-140 (145) alignment 
Range on Protein: 251-399
Range on HMM: 3-140/145.0
FPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHfHNRVVRIMIDDHNVPTL-HQMVVFTKEVNEWMAQDleNIVAIHCKGGTDRTGTMV
.||   ...|....  ....   |. ....|.||.||. .  .. . ..... ..||.||.|  ..  | . ..|.....  . |..||. | .||||.|
wpseilpglylgslptaldlellkdlgittvlnltselellerl.giqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv

CAFLIASEIcSTAKESLYYFGERRtdkthsekFQGVETPSQKRYVAYFAQ
.|.|. ..   .. | | .. ..|        ...|..|.| |.. .| .
aaylmlllg.vsleealelvrsqr........pgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 251-398 9.5e-22 72.7 In-house 3-141 (144) alignment 
Range on Protein: 251-398
Range on HMM: 3-141/144.0
FPSSGRQSFYRNPIKEVVRFLDKKHRNHYRVYNLCSERAYDPKHFH-NRVVRIMIDDHNVPTL-HQMVVFTKEVNEWMAQDleNIVAIHCKGGTDRTGTM
.||   ...|....  ....   |. ... |.||..|. ..   ..  ..... ..||.||.| ...  | . ..|.....  . |..||..| .||||.
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtl

VCAFLIASEiCSTAKESLYYFGERRTdkthsekfQGVETPSQKRYVAYFA
|.|.|.  .   ...| |... .||         ..|..|.| |.. .. 
vaaylmkkl.glsleealalvrsrrp........gavpnpgqlrfLleye
0051429 (Phosphotyrosine protein) phosphatases II 265-399 8.9e-09 30.9 In-house 89-222 (272) alignment 
Range on Protein: 265-399
Range on HMM: 89-222/272.0
KEVVRFLDKKHRNHYRVYNLCSERAYDPKHF--HNRVVRIMIDDHNVPTlHQMVVFTKEVNEwmaqdlENIVAIHCKGGTDRTGTMVCAFLIASEICSTA
. .|..| ... ..| ...|. .. ....    .   . . . ||.||. .... . .....      .. | .||..| |||||.|...|..  .. ..
alrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpq.eallellellld......ggpvlvHCsaGkdRTGtvvallllllgvslet

KESLYYF----GERRTDKTHSEKFQGVETPSQKRYVAYFAQ
    |       |.  ..  .   . |.|. | ...  ...
ivddYlltnlyleeaveelraqrpgavqteeqylflyeall
0047943 (Phosphotyrosine protein) phosphatases II 267-396 6.8e-18 60.5 In-house 138-266 (273) alignment 
Range on Protein: 267-396
Range on HMM: 138-266/273.0
VVRFLDKKHRNHYRVYNLCSER-AYDPKHFHNRVVRIMIDDHNVP-TLHQMVVFTKEVNEWMAQD-LENIVAIHCKGGTDRTGTMVCAFLIA----SEIC
 |..|. .....| |..|. ..  .. ... . .    . ||.|| .| ... | ..|.......  .. |..||..|  ||||.....|.      | .
tvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekegg

STAKESLYYFGERRtdkthsekFQGVETPSQKRYVAY
 ...| .... ..|        . .|.||.| |.. .
vdvleavkllrsqR........pgmvqtpeqyrflye
0051299 (Phosphotyrosine protein) phosphatases II 267-396 2.4e-16 55.5 In-house 150-280 (288) alignment 
Range on Protein: 267-396
Range on HMM: 150-280/288.0
VVRFLDKKHRNHYRVYNLCSERA--YDPKHFHNRVVRIM---IDDHNVPT-LHQMVVFTKEVNEWMAqDLENIVAIHCKGGTDRTGTMVCAFLIASEICS
.|..|. .. ..| |..|. ..   .|..... .|  .    . ||.||. . ... | ..|....| . .. |..||. | .||||.....|. . .  
tvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlek

TAKESLYYFGERRTDKTHSekfqGVETPSQKRYVAY
. . ... . .|   . .      |.||.| |.| .
eggvdvleavkrlreqRpg....mvqtpeqyrfvye
0050432 (Phosphotyrosine protein) phosphatases II 267-365 7e-13 44.0 In-house 169-266 (308) alignment 
Range on Protein: 267-365
Range on HMM: 169-266/308.0
VVRFLDKKHRNHYRVYNLCSERAYDPKH-FHNRVVRIMIDDHNVPT-LHQMVVFTKEVNEWMaQDleNIVAIHCKGGTDRTGTMVCAFLIASEICSTAKE
.|..|. .....| |..|. .   |..  . .    .   ||.||. . ... | ..|.... ..  . ...||. |  ||||.... |. . .  . . 
tvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.pg..gpivVHCsaGvGRtGtfialdllleqlekeggv

S
.
d
subfamily_PRL_pd Subfamily PRL 269-376 5.3e-06 20.6 In-house 25-133 (151) alignment 
Range on Protein: 269-376
Range on HMM: 25-133/151.0
RFLDKKHRNHYRVYNLCSERAYDPKHFHNR---VVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEIcsTAKES
.| .. .... .    . | .|| ......   |. .  || .||. . .  . . ..|  ... ...||.||  |  |.  .|.  || . .  . ...
kfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalalieaGm..kyeda

LYYFGERRTDK
. .  |.| . 
vefirekrrga
DSPc_SM00195 273-375 3.1e-07 25.4 In-house 135-228 (263) alignment 
Range on Protein: 273-375
Range on HMM: 135-228/263.0
KKHRN-HYRVYNLCSERAYD-PKHFHNRVVRIMIDDHNVP-TLHQMVVFTKEVNEWMAQDlENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKeslyyf
..... .. ...|  .   .  ... . .      ||.|| . .... . ..|...  .  .. . .||. | .||||.|.. .| |..... |      
vekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekk......

gerrtD
     .
.....v
PTPc_SM00194 273-375 3.1e-07 25.4 In-house 135-228 (263) alignment 
Range on Protein: 273-375
Range on HMM: 135-228/263.0
KKHRN-HYRVYNLCSERAYD-PKHFHNRVVRIMIDDHNVP-TLHQMVVFTKEVNEWMAQDlENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKeslyyf
..... .. ...|  .   .  ... . .      ||.|| . .... . ..|...  .  .. . .||. | .||||.|.. .| |..... |      
vekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskleeekk......

gerrtD
     .
.....v
CodY CodY GAF-like domain 275-350 1e-06 15.5 Pfam-A 55-127 (177) alignment 
Range on Protein: 275-350
Range on HMM: 55-127/177.0
HRNHYRVYNLCSERAYdPKHFHNRVVRIMIDDHNVPTLHQMVVFTKEVNEWMAQDLENIVAIHckGGTDRTGTMVC
. .. || .| .|.   |... ......     |..  ....||..| .| ... |  || |.  || .| ||.. 
kiendrvkqlleekkf.peeytekllnvketeanleidseltvfpeeekekfkkglttivPie..gggeRLGtlil
0048567 (Phosphotyrosine protein) phosphatases II 276-355 1.2e-06 22.9 In-house 14-101 (157) alignment 
Range on Protein: 276-355
Range on HMM: 14-101/157.0
RNHYRVYNLCSERAYDPKHFHN-R--VVRIMIDDHNVPTLHQMVVFTKEVNEWMA--QDLENIVAIHCKGGT---DRTGTMVCAFLIA
|  . ..    .. |....|.  .  |   .. |.  ..|.. . | . .|...   .  .. .|.||| |     ||.|.....|| 
rlyfallprlpkslynalyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlil
PTPc_motif_SM00404 277-382 1.1e-08 30.1 In-house 41-130 (140) alignment 
Range on Protein: 277-382
Range on HMM: 41-130/140.0
NhyrvynlcseraydPKHFHNRVVRIMIDD-HNVPTLHQMVVFTKEVNEWmaQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAkESLYYFGERRTD
.               .. . ....| .|| .. ......   .. ...   .. .  | .||. |  |..|...|.|. .. .|.| |..... |||  
t..............kensgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrqlsla.eayefvkerRpi

KTHSEKF
  ....|
ispnlnf
subfamily_DSP11_pd Subfamily DSP11 286-378 2.5e-13 44.3 In-house 66-162 (178) alignment 
Range on Protein: 286-378
Range on HMM: 66-162/178.0
SERAYDPKHFHNRV---VRIMIDDHNVPTLHQMVVFTKEVNEWM--AQDLENIVAIHCKGGTDRTGTMVCAFLIASEICStAKESLYYFGERRTDKTH
 .| |..|.....    .....  |.||. . .  |...|.|..   .| ......||  | .||| ..| .||  |  . .....  | | |  .  
tdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegye.pedaieafeearGhsle
subfamily_RNGTT_pd Subfamily RNGTT 286-380 1e-11 38.9 In-house 64-161 (189) alignment 
Range on Protein: 286-380
Range on HMM: 64-161/189.0
SERAYDPKHFHN---RVVRIMIDDHNV-PTLHQMVVFTKEVNEWMAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICStAKESLYYFGERRTDKTHSE
 .| || .....   . |.. .  . . |.  |.  | | |.|....  |.....||. | .||| .....|.  | .| .....  | . |    . |
tsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedws.veaavalFakaRppGiyke
DSPc Dual specificity phosphatase, catalytic domain 286-383 9.6e-10 33.4 Pfam-A 30-124 (133) alignment 
Range on Protein: 286-383
Range on HMM: 30-124/133.0
SE-RAYDPKHFHNRVVRiMIDDHNVPTLHQMVVFTKEVNEWmaQDLENIVAIHCKGGTDRTGTMVCAFLIASEICsTAKESLYYFGERRTDKTHSEKFQ
.. .|. ......  .  . |...  .  ..   .. ...   .. .. |..||. |  |..|...|.|. .. . ...| .... |||    ....|.
pnnnaikkseieylrip.vedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknl.slneAyefvkerrskispnagfl
DSPc Dual specificity phosphatase, catalytic domain 286-383 9.6e-10 33.4 In-house 30-124 (133) alignment 
Range on Protein: 286-383
Range on HMM: 30-124/133.0
SE-RAYDPKHFHNRVVRiMIDDHNVPTLHQMVVFTKEVNEWmaQDLENIVAIHCKGGTDRTGTMVCAFLIASEICsTAKESLYYFGERRTDKTHSEKFQ
.. .|. ......  .  . |...  .  ..   .. ...   .. .. |..||. |  |..|...|.|. .. . ...| .... |||    ....|.
pnnnaikkseieylrip.vedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknl.slneAyefvkerrskispnagfl
subfamily_DSP19_pd Subfamily DSP19 292-361 6.4e-06 20.6 In-house 53-119 (152) alignment 
Range on Protein: 292-361
Range on HMM: 53-119/152.0
PKHFHNRVVRIMiDDHNVPTLHQMVVFTKEVNEwmAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICST
||.|.   . |. |. .   |...   .. ..|  |.. ...| .||. |  |. ..| |.|...|  |.
pkdftylsieil.DlpetdllsylkealdFiee..arskdgavlvHCnAGvSRsasvviaylmkkeelsl
subfamily_PTPMT1_pd Subfamily PTPMT1 293-364 1.5e-06 22.8 In-house 70-140 (171) alignment 
Range on Protein: 293-364
Range on HMM: 70-140/171.0
KHFHNRVVRIMIDDHN-VPTLHQMVVFTKEVNEWmaQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKE
|.     ... . |.   |.|...    . ...   ... . | .|||.|  |..|.| ..|. .| .|. . 
kklgveqlqlatvDfteapdleklekgvefiekv..askgkrvYvHCkaGrgRsatlvacylmkkeklspeeA
Y_phosphatase Protein-tyrosine phosphatase 294-362 1.3e-06 23.4 Pfam-A 134-201 (235) alignment 
Range on Protein: 294-362
Range on HMM: 134-201/235.0
HFhNRVVRIMIDDHNVP-TLHQMVVFTKEVNEWMaQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTA
.. . .      ||.|| . .... . ..|...  .. .. | .||. |. ||||.|.. .. ... .. 
ev.kqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaee
Y_phosphatase Protein-tyrosine phosphatase 294-362 1.3e-06 23.4 In-house 134-201 (235) alignment 
Range on Protein: 294-362
Range on HMM: 134-201/235.0
HFhNRVVRIMIDDHNVP-TLHQMVVFTKEVNEWMaQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTA
.. . .      ||.|| . .... . ..|...  .. .. | .||. |. ||||.|.. .. ... .. 
ev.kqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleqleaee
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 296-403 1.5e-06 22.5 In-house 173-272 (288) alignment 
Range on Protein: 296-403
Range on HMM: 173-272/288.0
HNRVVRIMIDDHNVPTLHQMVVFTKEVNewmaQDLENIVAIHCKGGTDRTGTMVCAFLIASEICSTAKESLyyfgERRTDKTHSEKFQGVETPSQKRYVA
   .     ||. ||  ..  .   ||     ..|.. . .|.. |. ||||..  ....  ....   ..    ..   |   |.|. ..|  |  || 
vkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililialeslrlddflgi....rsllaklreerfkaiqtemqylyvh

YFAQVKHL
     . |
rcvleell
subfamily_DSP23_pd Subfamily DSP23 299-361 7.1e-11 37.0 In-house 54-114 (148) alignment 
Range on Protein: 299-361
Range on HMM: 54-114/148.0
VVRIMIDDHNVPTLHQMVVFTKEVNEwmAQDLENIVAIHCKGGTDRTGTMVCAFLIASEICST
.||. |||.  |.|.|.| | . |.|  |.. .. |..||  |  |||||.  .|.  .  ..
lvrlriddyhppaleqvvefvrvvee..aeekneavsvhcllgrgrtgtmlacylvkerklaa
PTPc_DSPc_SM00012 304-366 1.1e-09 33.8 In-house 10-75 (105) alignment 
Range on Protein: 304-366
Range on HMM: 10-75/105.0
IDDHNVPT-LHQMVVFTKEVNEWMAQDL-ENIVAIHCKGGTDRTGTMVCAFLIASEICSTA-KESL
. ||.||.  . .. . ..|.... .   .. | .||. | .||||.|.. .. . ....  . ..
wpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdi
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 409-538 5.2e-31 98.6 Pfam-A 1-133 (134) alignment 
Range on Protein: 409-538
Range on HMM: 1-133/134.0
PPRRILFIKHFIIYSIPRY----VRDLKIQIEMEKKVVFstISLGKCSVLDNITTDKILIDVFDGLPLYDDVKVQFFYSNLPTYYDNCSFYFWLHTSFIE
.....|..|..|...||..      ..|... ..||.||   .|.. .  ..  ........  .||...||.|.|. ..  ...... |..|..|||||
ynpkrlelksiilegiPnfktrggckpkvkvyngkkkvf..kelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFie

--NNRLYLPKNELDNLHKQKaRRIYPSDFAVEILFG
  .|.|.|||||||...|.|  . ....|.||..| 
knqnvltlpkneLDkalkdk.dkkfsknfkvelvfe