Gene TPTE2 in Homo sapiens

Synonym: TPIP, RP11-408K19.2, TPTE2

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTEN
Subfamily VSP
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP069_AA protein Get Run
HsapP069_AA_167-392 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Ion_trans Ion transport protein 115-205 2.6e-11 31.5 Pfam-A 6-91 (200) alignment 
Range on Protein: 115-205
Range on HMM: 6-91/200.0
IGLFFLMDVLLRVFVEGR--QQYFSDLFNILDTaIIVIPLLVDVIYIFFDIKLLrniprwTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLV
. ..|....||.... |   . |..|..||||  ..|.|.||..|. ... .        ..|...|||. ..|.. |.   ..|..|.. |.
ftviftlemllkiialgfkkftylrdpwnilDf.lvvlpslvslilrllnkesa......egllsvlrllrvlRllrlisrieglrtllgsli
0043336 (Phosphotyrosine protein) phosphatases II 168-380 1.1e-30 102.5 In-house 7-273 (278) alignment 
Range on Protein: 168-380
Range on HMM: 7-273/278.0
NIPRWTHLVRLLRLIILIRIFHLLHQKRQLEKLMRRLVSENKRRY-------------TRDGFDLDLTYV----------TERIIAMSFPSSGRQSFYRN
 . .. .|.. |. ..|   ..||..|    .  ... . .|.||             . .|.|||..|.          ....||...|...    ...
llkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwr

PIEE----------------------------------VVRFLDKKHRNHYRVYNLCSER-AYDPKHFHNRVSRIMIDDHNVP-TLHEMVVFTKEVNEWM
 . |                                  .|..|. .| ..| |..|. ..  ..........  . . ||.|| .|  .. | |.|.|..
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreal

AqDLENIVAIHCKGGKGRTGTMVCALLIA----SEIFLTAEESLYYFGERRtnkthsnkFQGVETPSQNRYVGYFA
. | .. |..||..|.|||||.....|.     .| ....|| . .. |.|        .. |.|||| |.. ...
e.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqR........pgavqtpsqyrflyeal
0039614 (Phosphotyrosine protein) phosphatases II 179-388 1.1e-33 112.4 In-house 23-293 (297) alignment 
Range on Protein: 179-388
Range on HMM: 23-293/297.0
LRLIILIRIFHLLHQKRQL------EKLMRRLVSENKRRYT--------------RDGFDLDLTYV-----------TERIIAMSFPSSG-----RQSFY
|.|. .  . .|| .  .|       .  .. .. .|.||.               ||.|||..|.           | ..||...|...      . ..
lllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvw

RNPIEEVV----------------------------RFLDKKHRNHYRVYNLCSERaYDPKHFHNRVSRIMIDDHNVP-TLHEMVVFTKEVNEWMAQD-L
.. .. .|                            ..|. .|...| |..|. .. ... ......  . . ||.|| .|  .  | ..|.|..|..  
eqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtn.ngesrtvthfqytgwpdhgvppslellleflelvrealaelpk

ENIVAIHCKGGKGRTGTMVCALLIA----SEIFLTAEESLYYFGERRtnkthsnkFQGVETPSQNRYVGYFAQVKHLYNW
.. |..||..|.|||||...|.|.     .|  ....| . .. |.|         ..|.|||| |.. ....   ....
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqR........pgavqtpsqyrflydallellkrkl
0040438 (Phosphotyrosine protein) phosphatases II 184-392 3.7e-27 90.9 In-house 21-284 (317) alignment 
Range on Protein: 184-392
Range on HMM: 21-284/317.0
LIRIFHLLHQKRQLEKLMRRLVSENKRRY-------------TRDGFDLDLTYV----------TERIIAMSFPSSG-----RQSFYRNPIEEVVRFLDK
|   ..||..|    .  ..... .|.||             . .|.|||..|.          . ..||...| ..      . .... .. .|.. . 
leefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLtel

K------------------------------HRNHYRVYNLCSERAYDPKHFHNRVSRIMI-DDHNVP-TLHEMVVFTKEVNEWMAqDLENIVAIHCKGG
.                              . ... ...|. |  .|........   .  .||.|| .. ... | ..|.|... | .. |..||..|
eelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpvlVHCsaG

KGRTGTMVCALLIA----SEIFLTAEESLYYFGERRtnkthsnkFQGVETPSQNRYVGYFAQVKHLYNWNLPP
.|||||...|.|.      | ....|| .... |.|         ..|.||.| |.. ....  ......|.|
vgRtGtfiaaylmleqlekeggvdveeavkelreqR........pgavqtpeqyrflydalleylkrkltlep
subfamily_VSP_pd Subfamily VSP 186-396 5e-128 419.2 In-house 1-211 (212) alignment 
Range on Protein: 186-396
Range on HMM: 1-211/212.0
RIFHLLHQKRQLEKLMRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIM
||..||.|||.|||..||||||||||||.|||||||||||||||||||||||.||.|||||.||.||||.|||.||.|.|||||||||.|.|.|||.||.
rilrlltqkrklekaarrlvsenkrrytqdGfdldltyvteriiamsfpssGkqslyrnpisevarfldtkhrdhykvvnlcseraydekyfnnrvkril

IDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKTHSNKFQGVETPSQNRYVGYFAQVKHL
|||||||.|.|..||||||.||...||.|..|||||||||||||.|||||.||||| ||.|||.|||||||.||...|||||.||||.|||||..|||..
iddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvgyleqvktk

YNWNLPPRRIL
||..|||...|
ynrklppaktl
0036941 (Phosphotyrosine protein) phosphatases II 197-381 2.6e-16 55.2 In-house 19-274 (297) alignment 
Range on Protein: 197-381
Range on HMM: 19-274/297.0
LEKLMRRLVSENKRRYTR-----------------------------------DGFDLDLTYV---------------------TERIIAMS--------
 |.|...|.. ... . .                                   ||.||. ...                     .. |. ..        
feellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgre

-----FPSSGRQSFYRNPIeeVVRFLDKKH--RNHYRVYNLCSER-AYDPKHFHNRVSRIMIDDHNVPT-LHEMVVFTKEVNEWMAQD-LENIVAIHCKG
     .|.  ..|.. ...  .|..|. ..   ..| ...|. .   ...... .    . ..||.||.   ... | ..|......   .. | .||..
kcaqywpleegesltygdf..tvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsa

GKGRTGTMVCALLIASEIF-------LTAEESLYYFGERRTNkthsnkfqGVETPSQNRYVGYFAQ
|.||.||...| |. . .        ..  | . .. |.| .         |.|..| |.. .. .
GvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpg........avqtleqyrflyeall
subfamily_PTEN_pd Subfamily PTEN 201-382 9e-69 226.1 In-house 2-178 (184) alignment 
Range on Protein: 201-382
Range on HMM: 2-178/184.0
MRRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVF
.|..||..|.|...||.||||.|.||.||||..|. . .. ||| .|.||.||.|||..||..|||.|||.|| |.|..||. . .|||| |.|. .  .
lrkivskkkkrfkedgldLDlsyiteniiamgyPaeklealyRnsledvvkflekkhkdhykiynlrserkydskkfdgrvavypfdDhnppplelleei

TKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKThsnkfQGVETPSQNRYVGYFAQV
 .....|...| .|.|..||| ||||||....|.|. | .. .|||.| .| | ||...     .||  ||| ||| |. ..
vediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaRtknk.....kgvtiPsqrRYveYyekl
0042113 (Phosphotyrosine protein) phosphatases II 201-380 1.7e-28 95.1 In-house 4-239 (245) alignment 
Range on Protein: 201-380
Range on HMM: 4-239/245.0
MRRLVSENKRRY-------------TRDGFDLDLTYV----------TERIIAMSFPSSGRQS-----FYRNPIEEVV----------------------
 ..... .|.||             . ||.|||..|.          |...||...|...        .... |. .|                      
allpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplges

--------RFLDKKHRNHYRVYNLCSER-AYDPKHFHNRVSRIMIDDHNVPT-LHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIA---
        ..|. .| ..| |..|. ..  .|........ .. ..||.||. |  .. | ..|....|.| .. |..||..|.|||||...|.|..   
ltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleql

-SEIFLTAEESLYYFGERRtnkthsnkFQGVETPSQNRYVGYFA
 .|  ...|| .... ..|         . |.|||| |.. ...
ekelgvsleeavkelrsqR........pgavqtpsqyrflyeal
0045450 (Phosphotyrosine protein) phosphatases II 201-380 1.6e-25 85.9 In-house 50-300 (307) alignment 
Range on Protein: 201-380
Range on HMM: 50-300/307.0
MRRLVSENKRRYTR-------------------------------------DGFDLDLTYV----------------------------------TERII
 ..... .|.||.                                      ||.||.....                                  . ...
allpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekc

AMSFPSSGRQSFYRNpieEVVRFLDKKHRNHYRVYNLCSERaYDPKHFHNRVSRIMI---DDHNVP-TLHEMVVFTKEVNEWMAQD-LENIVAIHCKGGK
|. .|..| .  |.|    .|..|...| ..| |..|. .. .|..... .|  .      ||.|| .. |.. | .||.......  .. |..||..|.
aqywPdegeeltygn...ftvtllseehldgytvrtlevtd.ldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGv

GRTGTMVCALLIASEI-------FLTAEESLYYFGERRtnkthsnkFQGVETPSQNRYVGYFA
|||||...|.|. . .       .....| . .. |.|         ..|..|.| |.. ...
gRtGtfiaaylmlrqlekegtlldvdlleavkllreqR........pgavqnpeqyrflyeal
0044763 (Phosphotyrosine protein) phosphatases II 202-385 1.2e-21 72.6 In-house 4-172 (178) alignment 
Range on Protein: 202-385
Range on HMM: 4-172/178.0
RRLVSENKRRYTRDGFDLDLTYVTERIIAMSFPSSG-RQSFYRNPIEEVVRFLDKKHRNHYRvynlcsERAYDPKHFHNRVSRIMIDDHNVPT-LHEMVV
| .|. ......  .. .............|.|..  .. .... |  .|.. . ......       . .|.|. .. .. .| |.||.||. |  .  
rtrvllsnleglersdyinaseilpglylgslppaddlellkelgithivnlteelelgflk......cdpywpeeagiqylhipipDhgvpdllehfle

FTKEVNEWM-AQDleNIVAIHCKGGKGRTGTMVCALLIASEiFLTAEESLYYFGERRtnkthsnkFqGVETPSQNRYVGYFAQVKHL
|.. ..|..  ..  . |..||. |.||.||.|.| |. .   |..|| . .. |||        . .|..|.| |.. .|..  . 
fvefieealdekg..gpvlVHCsaGvgRsgtlvaaylmkkl.glsleeaielvrerR........p.ivpnpgqlrqLyefelrllk
0037934 (Phosphotyrosine protein) phosphatases II 203-380 3.1e-31 104.2 In-house 7-238 (243) alignment 
Range on Protein: 203-380
Range on HMM: 7-238/243.0
RLVSENKRRYT--------------RDGFDLDLTYVTERIIAMSFPSSG---------RQSFYRNPIEEVV----------------------------R
.... .|.||.               | ....|.|||.|.||...| ..          . .... |. .|                            .
lpenlsknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvt

FLDKKHRNHYRVYNLCSER--AYDPKHFHNRVSRIMIDDHNVPT-LHEMVVFTKEVNEWMAQ-------DLENIVAIHCKGGKGRTGTMVCALLIASEIF
.|. .| ..| |..|. |.  ..|..... .. .. . ||.||.    .. | .||.|.. .       | .. |..||..|.|||||...|.|. . . 
llseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllg

LTAEESLYYFGERRTNkthsnkfQGVETPSQNRYVGYFA
...|| . .. |.| .        .|.|||| |.. ...
vdleeavkllreqRpg.......kavqtpsqyrflyeal
0040439 (Phosphotyrosine protein) phosphatases II 203-380 1.1e-25 86.1 In-house 8-242 (249) alignment 
Range on Protein: 203-380
Range on HMM: 8-242/249.0
RLVSENKRRYT---------------RDGFD--------LDLTYVTERIIAMSFPSSGRQSFYRNPIEE-------------------------------
.... .|.||.               ...|.        .|..|.. |.||...| ..  . ... . |                               
lpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsle

----VVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRI-MIDDHNVP-TLHEMVVFTKEVNEWMAQD-LENIVAIHCKGGKGRTGTMVCALLIA----
    .|..|. .. ..| |..|. .. ||..... .. ..  . ||.|| .. ... | ..|.......  .. |..||..|.|||||...|.|.     
ygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqle

SEIFLTAEESLYYFGERRtnkthsnkFQGVETPSQNRYVGYFA
 |  ...|| . .. ..|        ...|..|.| |.. ...
kelgvdleeavkllrsqR........pgavqnpeqyrflyeal
PTEN_1 205-383 1.1e-47 157.4 In-house 6-192 (196) alignment 
Range on Protein: 205-383
Range on HMM: 6-192/196.0
VSENKRRYTRDGFDLDLTYVTERIIAMS-FPSSG-----RQSFYRNPIEEVVRFLDKKHRNH-YRVYNLCSERA-----YDPKH-FHNRVS--RIMIDDH
 . .|... .....|||||.|.|||||. .|| .      .. ||.....|...|| .. .. . |.||..|..     ||... |...|.  ...|.||
krsskknlalptelldltyitsriiamgkapsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDh

NVPTLHEMVVFTKEVNEWMAQDL-ENIVAIHCKGGKGRTGTMVCALLIASEIfLTAEESLYYFGERRTN-KTHsnkfqgveTPSQNRYVGYFAQVK
..|.|.|.  . |.. ||. .|  .|.|..|||.|.||.||.|.|.|....  |||.| | .. |.|..   .        .|||.|.. |||. .
gapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgk.ltadeAlelvrekRppgapn........spsqerlleyfaell
0046845 (Phosphotyrosine protein) phosphatases II 207-383 3.7e-25 84.3 In-house 29-273 (284) alignment 
Range on Protein: 207-383
Range on HMM: 29-273/284.0
ENKRRYTR-----------------------------DGFDLDLTYVTERIIAMSFPSSG-----------------------------RQSFYRNPIEE
 .| ||.                              ||.||||||.. ..||...| ..                               ..|.....|
lsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvrvIVmltelvengrekcaqYwplege

VVRF-------LDKKHRNHYRVYNLCSERA--YDPKHFHNRVSRIMIDDHNVPT-LHEMVVFTKEVNEWMAQ-DLENIVAIHCKGGKGRTGTMVCALLIA
|...       |.......| |..|. ..    .. ....    . . ||.||. .  .. | ..|.|.. . . .. ...||..|.|||||.... |. 
vltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdlll

SEI-------FLTAEESLYYFGERRtnkthsnkFQGVETPSQNRYVGYFAQVK
. .        ....| .... |.|        .. |.|..| |.| ....  
eqlekeglllgvdvleavkrlreqR........pgmvqtleqyrfvyealley
0041856 (Phosphotyrosine protein) phosphatases II 209-392 1.2e-31 105.1 In-house 4-179 (182) alignment 
Range on Protein: 209-392
Range on HMM: 4-179/182.0
KRRYT---RDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYR-VYNLCsERAYDPKHFHN---RVSRIMIDDHNVPTLHEMVVFT
|.||.   .  ...||.|........|.|..    ........| .||.  ...... . ||. |. |.|.....   .. .. ..||.||.|.|.. | 
knrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.eelywpellerlgiqylylpwpDhgvpdldelldfi

KEVNEwmaqdLENIVAIHCKGGKGRTGTMVCALLIASEiFLTAEESLYYFGERRtnkthsnkFQGVETPSQNRYVGYFAQVKHLYNWNLPP
.||.|      .. |..||..|.|||||.|.| |. .   ...|| . .. .||        ...|.||.|.... ...  ..|.... |.
eevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl.gvsleeavklvrsrR........pgmvitpnqyfflqlallellllkktrpk
subfamily_Tensin_pd Subfamily Tensin 210-382 1.4e-47 154.7 In-house 2-170 (189) alignment 
Range on Protein: 210-382
Range on HMM: 2-170/189.0
RRYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLcSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMA
 ||... .||||||.||||||.|||..| .. ||. ...|...|..||...|.|.|| ||. || ......|  .   |.  |.|  .    |....|. 
vryveekvdldltyiteriialsfpaegleekyrenlkdvakllkskhndkylvfnl.sekrydisklnkkvldfGWPdllaPsleklcsicksldsWlk

QDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTnktHSNKFQGVETPSQNRYVGYFAQV
.|..|.|..||||||||.| .| | .  |.|  .|...|  |  .|      .| .|.  |||.||| || ..
adpqnvvvvhckGgkgrigvvvsaymkyskisasadaaldrfamkrf...lddklsgetqPsqrryveyfsgl
0043147 (Phosphotyrosine protein) phosphatases II 210-385 2e-31 104.4 In-house 4-162 (172) alignment 
Range on Protein: 210-385
Range on HMM: 4-162/172.0
RRYTRDGFDLDLTYVTERIIAMSFPssgrqsfYRNPIEEVVRFLDKKHRNHyrVYNLCsER---AYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNE
...  . ..|||.|.. |.||. .|       .||......|.| ... .|  ..||. |.   ... ...  .. .. ..||.||.|  .  | . ..|
gsdyinasyldlyyipdrfiatqgp.......lrntladfwrmlkelgith..ivnlt.ellydpellerlgiqylylpwpDhgvpllellleflefide

WMAQDLENIVAIHCKGGKGRTGTMVCALLIAseIFLTAEESLYYFGERRtnkthsnkFQGVETPSQNRYVGYFAQVKHL
..|.. .. |..||..|.|||||.|.|.|.     |..|| . .. |.|        ...|..||| |.. ||..  .|
llalspggpvlVHCsaGvgRtgtlvaaylml..lglsleeavalvrekR........pgavqnpsqyrflyyfekllll
0046846 (Phosphotyrosine protein) phosphatases II 211-381 4.6e-31 103.3 In-house 2-170 (176) alignment 
Range on Protein: 211-381
Range on HMM: 2-170/176.0
RYTRDGFDLDLTYVTERIIAMSFPSSGRQSFYR-----------NPIEEVVRFLDKKHRNHYRVYNLCSEraydPKHFHNRVSRIMIDDHNVPTLHEMVV
|....|.||||.|.....|..|.|  .  . .|           . |. ||.... .. ......|...|     . .. .. .. ..||.||.|  .  
rlrllgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgiqylhlpwpDhgvpdlellle

FTKEVNEWMAQDleNIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNkthsnkfQGVETPSQNRYVGYFAQ
. ....|.  ..  . |..||..|.|||||.|.|.|. .| .|..|| |... |.| .       . |.||.| |.. .|..
llefirealkeg..gpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRpl.......gavqtpeQyrflyefel
0036282 (Phosphotyrosine protein) phosphatases II 216-380 4.5e-40 132.5 In-house 7-166 (174) alignment 
Range on Protein: 216-380
Range on HMM: 7-166/174.0
GFDLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENI
 ..|||.|.|.|.||...| .  . .... |. ||..|. |....|...|...|. .|..... .. .....||.||.|...  | |.|.|....| .. 
aspldlsyitprliagqgplafwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggp

VAIHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNkthsnKFQGVETPSQNRYVGYFA
|..||..|.|||||.|.|.|.   .. .... |... |.|.      . ..|.|||| |.. || 
vlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlq.....rpgmvqtpsQyrflyyfe
0045098 (Phosphotyrosine protein) phosphatases II 216-386 1.6e-22 75.6 In-house 4-274 (278) alignment 
Range on Protein: 216-386
Range on HMM: 4-274/278.0
GFDLDLTYVTERIIAMSFPSSGRQSFYRNPIE--------------------------------------------------------------------
...|||.. .|.......||.   . |.....                                                                    
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgr

-----------------------EVVRFlDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLH---EMVVFTKEVNEWMA------------
                       .. .. |. .  ...|.||..||....... . .  . ..||.||.|.    .  ......|...            
ekcaqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslll

QDLENIVAIHCKGGKGRTGTMVCALLIASEI--FLTAEESLYYFGERRtnkthsnkFQ-GVETPSQNRYVGYFAQVKHLY
.| .. |..||. |.|||||.|.| |. . .   ....| . .. ..|         .  |....| |.. .|..  .|.
ldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqR........pglavqnleqyrflyefllelllr
subfamily_Auxilin_pd Subfamily Auxilin 218-382 1.3e-43 141.6 In-house 8-163 (166) alignment 
Range on Protein: 218-382
Range on HMM: 8-163/166.0
DLDLTYVTERIIAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLcSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVA
|||..|.| ||| ||||. | .| |.| |..|  ||. .| ..| |||| |.| |.......||. . .  ...| |...|  ....  |. .| .|.| 
dlDisyitsriivmsfPaegvestyknniddvrsfLesrhpekylvynl.sqrtyrtaklssrvveagwparraPnLeslvevcrnlyswlkkdpknvvv

IHCKGGKGRTGTMVCALLIASEIFLTAEESLYYFGERRTNKThsnkfqgvETPSQNRYVGYFAQV
.||| |.  ....|.|||.  ... ..|.... |  .|. .          .||..||. |.|..
vhckDGraasavlvsallvfcrllsepesavrlfsvkrlpig........lspsekryleyladl
0051082 (Phosphotyrosine protein) phosphatases II 219-362 2e-23 78.1 In-house 6-139 (151) alignment 
Range on Protein: 219-362
Range on HMM: 6-139/151.0
LDLTYVTERIIAMSFPSSgrqsfyrnpieEVVRFLdkKHRNHYRVYNLCS--ERAYDPKHFHN---RVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLE
....|||........|..           .....|  |. ... ..||.|  ||.|.|. ...   .| .| |.|. .|.| ..  . .|. |..... .
infsyvtgglyrsggpla...........dflell..kelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkn

NIVAIHCKGGKGRTGTMVCALLIAseIFLTAEESLYYFGERRTNKTHSN
. |..||..|||||||.|...|..    ...|| | .. ..|.... .|
gpvlvHCsaGkgRTGtlvalylml..lgvsleealeeyrlkrpgvvqpn
0038934 (Phosphotyrosine protein) phosphatases II 223-360 1e-37 125.0 In-house 15-161 (194) alignment 
Range on Protein: 223-360
Range on HMM: 15-161/194.0
YVTERIIAMSFPSSG-----RQSFYRNPIEEVVRFLDKKHRNHYRVYNLC-SERAYDPKHFHN---RVSRIMIDD-HNVPTLHEMVVFTKEVNEWMAQDL
..|.|.||...|.||      ...||...| .||.|. ...... |..|. .|| |||..|..   .. .... | ..||.|  .  | . |.|....| 
iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedp

ENIVAIHCKGGKGRTGTMVCALLIASEIFlTAEESLYYFGERRTNKTH
...||.|||.|.|||||.|.| || .  . .|||....| |.| .   
ggvvaVHCkaGlgRtGtlvaaYLiyrlgm.saeeAialfrekRpgaip
subfamily_PTPDC1_pd Subfamily PTPDC1 224-361 1.4e-09 32.7 In-house 18-161 (182) alignment 
Range on Protein: 224-361
Range on HMM: 18-161/182.0
VTERIIAMSFPSSGR-------QSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNR---VSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDle
||| |.|.. ||.         . |  . |. |. . .|    .    .  |  .||.... ..   |  . ..|..|..|....   | |.  . ..  
vtedilalarpsqeaideyklldkfkesgikavinLqekgehasCGagleesGfsYdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqeg..

nIVAIHCKGGKGRTGTMVCALLIASEIfLTAEESLYYFGERRTNKTHS
  ||.||  |.|||| .... |. ..  ||||...    ..|..  ..
.kvavhChaGlGrtGvliacylvyakr.ltaekaiklvrskrpksiqt
subfamily_CDC14_pd Subfamily CDC14 226-350 1.2e-08 29.2 In-house 178-299 (328) alignment 
Range on Protein: 226-350
Range on HMM: 178-299/328.0
ERIIAMSFPSS---------------GRQSFYRNPIEEVVRfLDKKhrnhyrvynlcserAYDPKHFHNRV---SRIMIDDHNVPTLHEMVVFTKEVNEW
....|.. | .                 . | .| ...||| |.||               || |.| .     . ..  |  .|. . .  |.. ... 
dkflalagPhnkskledgyplhaPeklleyfrknnvttvvr.Lnkk..............lYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaeka

maqdlENIVAIHCKGGKGRTGTMVCALLIAsEIFLTAEESLYY
     |  .|.||| | |||||.. . |.  .  .||.|.. .
.....eGaiavhCkaGLGrtGtLiacylmk.hyrftaaeaiaw
0049772 (Phosphotyrosine protein) phosphatases II 227-390 1.3e-19 66.5 In-house 122-284 (314) alignment 
Range on Protein: 227-390
Range on HMM: 122-284/314.0
RIIAM---------------------SFPSSGRQsfyrnpieevvRFLDKKHRNHYRvynlcsERAYDPKHFHNRVSRI---MIDDHNVPTLHEMVVFTK
|.| |                       . .|..            ... ..  ...      |. |||..| ... .     ..|...|.|  .  | .
rdivmsrdevladelsrLdaAlgKtpllildgng...........neptaadlellk......eelydpelferlgikylripvpDgsaplledfdefle

EVNEWmaqDLENIVAIHCKGGKGRTGT-MVCALLIASEiFLTAEESLYYFGERRTnkTHSNKfQGVetPSQNRYVGYFAQVKHLYNWNL
 ..|.   | .. |..|||.||||||| .|.|.|.     ...|| | .. ..|.   . |.   .  .....|. .. ........ .
fieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll.gvsleealedvrlkRp..inpnp.gfi..eqleqyefilealleylkflk
0049260 (Phosphotyrosine protein) phosphatases II 229-381 4.4e-29 96.5 In-house 5-147 (152) alignment 
Range on Protein: 229-381
Range on HMM: 5-147/152.0
IAMSFPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTG
.||.|.  . |  ..|......|.| . . ... ... ..|....  ... .. .. ..||.||.|.... |  .. |..|.| .. |..||..|.||||
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtg

TMVCALLIAseIFLTAEESLYYFGERRtnkthsnkFQGVETPSQNRYVGYFAQ
|.|.|.|.     ...|| . .. |.|         ..|..|.| |.. .|..
tlvaaylml..lgvsleeavalvrekR........pgavpnpgqlrflyefek
0048076 (Phosphotyrosine protein) phosphatases II 233-380 4.4e-22 73.7 In-house 3-139 (145) alignment 
Range on Protein: 233-380
Range on HMM: 3-139/145.0
FPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHfHNRVSRIMIDDHNVPTL-HEMVVFTKEVNEWMAQDleNIVAIHCKGGKGRTGTMV
.||   ...|....  ....   |. ....|.||.||. .  .. . .. .. ..||.||.|   .  | . ..|.....  . |..||. |.|||||.|
wpseilpglylgslptaldlellkdlgittvlnltselellerl.giqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv

CALLIASEIfLTAEESLYYFGERRtnkthsnkFQGVETPSQNRYVGYFA
.| |. ..  ...|| | .. ..|        ...|..|.| |.. .| 
aaylmlllg.vsleealelvrsqr........pgavpnpgqlrflyefe
0048179 (Phosphotyrosine protein) phosphatases II 233-379 4.5e-22 73.8 In-house 3-140 (144) alignment 
Range on Protein: 233-379
Range on HMM: 3-140/144.0
FPSSGRQSFYRNPIEEVVRFLDKKHRNHYRVYNLCSERAYDPKHFH-NRVSRIMIDDHNVPTL-HEMVVFTKEVNEWMAQDleNIVAIHCKGGKGRTGTM
.||   ...|....  ....   |. ... |.||..|. ..   ..  .. .. ..||.||.| . .  | . ..|.....  . |..||..|.|||||.
npseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg..gpvlVHCsaGvgRtgtl

VCALLIASEIfLTAEESLYYFGERRTnkthsnkfQGVETPSQNRYVGYF
|.| |.  .  |..|| |... .||         ..|..|.| |.. ..
vaaylmkklg.lsleealalvrsrrp........gavpnpgqlrfLley
0051429 (Phosphotyrosine protein) phosphatases II 246-340 4e-09 32.0 In-house 88-177 (272) alignment 
Range on Protein: 246-340
Range on HMM: 88-177/272.0
IEEVVRFLDKKHRNHYRVYNLCSERAYDPKHF--HNRVSRIMIDDHNVPTlHEMVVFTKEVNEwmaqdlENIVAIHCKGGKGRTGTMVCALLIASEI
.  .|..| ... ..| ...|. .. ....    .     . . ||.||. .... . .....      .. | .||..||.||||.|..||..  .
galrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpq.eallellellld......ggpvlvHCsaGkdRTGtvvallllllgv
0047943 (Phosphotyrosine protein) phosphatases II 249-377 4.7e-19 64.3 In-house 138-265 (273) alignment 
Range on Protein: 249-377
Range on HMM: 138-265/273.0
VVRFLDKKHRNHYRVYNLCSER-AYDPKHFHNRVSRIMIDDHNVP-TLHEMVVFTKEVNEWMAQD-LENIVAIHCKGGKGRTGTMVCALLIA----SEIF
 |..|. .....| |..|. ..  .. ... . .    . ||.|| .| ... | ..|.......  .. |..||..|.|||||.....|.      |  
tvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekegg

LTAEESLYYFGERRTNkthsnkfqGVETPSQNRYVG
....| .... ..| .        .|.||.| |.. 
vdvleavkllrsqRpg........mvqtpeqyrfly
0051299 (Phosphotyrosine protein) phosphatases II 249-376 5.7e-17 57.5 In-house 150-278 (288) alignment 
Range on Protein: 249-376
Range on HMM: 150-278/288.0
VVRFLDKKHRNHYRVYNLCSERA--YDPKHFHNRVSRIMI---DDHNVPT-LHEMVVFTKEVNEWMAqDLENIVAIHCKGGKGRTGTMVCALLIASEIFL
.|..|. .. ..| |..|. ..   .|..... .|  .      ||.||. . ... | ..|....| . .. |..||. |.|||||.....|. . .  
tvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlek

TAEESLYYFGERRTNKTHSnkfqGVETPSQNRYV
. . ... . .|  .. .      |.||.| |.|
eggvdvleavkrlreqRpg....mvqtpeqyrfv
0050432 (Phosphotyrosine protein) phosphatases II 249-347 2.8e-13 45.3 In-house 169-266 (308) alignment 
Range on Protein: 249-347
Range on HMM: 169-266/308.0
VVRFLDKKHRNHYRVYNLCSERA-YDPKHFHNRVSRIMIDDHNVPT-LHEMVVFTKEVNEWMaQDleNIVAIHCKGGKGRTGTMVCALLIASEIFLTAEE
.|..|. .....| |..|. .   ... .. .    .   ||.||. . ... | ..|.... ..  . ...||. | |||||.....|. . .  . . 
tvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.pg..gpivVHCsaGvGRtGtfialdllleqlekeggv

S
.
d
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 250-374 8.8e-07 23.3 In-house 150-273 (319) alignment 
Range on Protein: 250-374
Range on HMM: 150-273/319.0
VRFLDKKHRNHYRVYNLCSERAYDPKHFhNRVSRIM---IDDHNVPTLHE-MVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMvCALLIASEIfLTAE
|  ..... ..| . .|. ... .      .|.. .     ||.||.    .. . |.... . .  .  . .||  | |||||  ..| .. |  .  |
vtleeeeeledyiirklklnkkssevet.RevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtf.ivldamler.vkee

ESLYYFGERRTNKTHSNKFqgVETPSQNR
. |  |   .. .|  |    |..|.| .
gvlDvfstvsrlRtqRnim..vqrpeqYk
subfamily_PRL_pd Subfamily PRL 251-363 3.3e-07 24.5 In-house 25-138 (151) alignment 
Range on Protein: 251-363
Range on HMM: 25-138/151.0
RFLDKKHRNHYRVYNLCSERAYDPKHFHN---RVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIasEIFLTAEES
.| .. .... .    . | .|| .....   .|  .  || .||. . .  . . ..|  ... ...||.||  | ||.  .|.  ||  |  .. |..
kfieelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalali..eaGmkyeda

LYYFGERRTNKTHSNK
. .  |.| .   |..
vefirekrrgainskq
DSPc_SM00195 254-340 1.7e-06 22.9 In-house 134-222 (263) alignment 
Range on Protein: 254-340
Range on HMM: 134-222/263.0
DKKHRN-HYRVYNLCSERAYD-PKHFHNRVSRIMIDDHNVP-TLHEMVVFTKEVNEWMAQDlENIVAIHCKGGKGRTGTMVCALLIASEI
...... .. ...|  .   .  ... . .      ||.|| . .... . ..|...  .  .. . .||. | |||||.|.. .| |..
evekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskl
PTPc_SM00194 254-340 1.7e-06 22.9 In-house 134-222 (263) alignment 
Range on Protein: 254-340
Range on HMM: 134-222/263.0
DKKHRN-HYRVYNLCSERAYD-PKHFHNRVSRIMIDDHNVP-TLHEMVVFTKEVNEWMAQDlENIVAIHCKGGKGRTGTMVCALLIASEI
...... .. ...|  .   .  ... . .      ||.|| . .... . ..|...  .  .. . .||. | |||||.|.. .| |..
evekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpivVhCsaGvgRtgtfvtidiilskl
CodY CodY GAF-like domain 257-332 1.5e-06 15.0 Pfam-A 55-127 (177) alignment 
Range on Protein: 257-332
Range on HMM: 55-127/177.0
HRNHYRVYNLCSERAYdPKHFHNRVSRIMIDDHNVPTLHEMVVFTKEVNEWMAQDLENIVAIHckGGKGRTGTMVC
. .. || .| .|.   |... ......     |..  .|..||..| .| ... |  || |.  ||. | ||.. 
kiendrvkqlleekkf.peeytekllnvketeanleidseltvfpeeekekfkkglttivPie..gggeRLGtlil
subfamily_PTPN3_pd Subfamily PTPN3 257-351 9.5e-06 19.7 In-house 153-244 (280) alignment 
Range on Protein: 257-351
Range on HMM: 153-244/280.0
HRNHYRVYNLCSERAYDPKHFHnRVSRIMIDDHNVPTL-HEMVVFTKEVNEWMAQDlENIVAIHCKGGKGRTGTMVCALLiASEiFLTAEESLYYF
.   .|   |. ... . .. . ..  .   ||.||.  .... |...|..  . . |. | .|| .| |||| ..   . |    . |.|..|  
ksyvlrelvlkdketkeerkil.qlqylaWpdhgvPddsadflefvervrklrsgk.eePvvvhCsaGigrtGvlillet.ala.lieaaepvypl
subfamily_PTPRK_pd Subfamily PTPRK 261-339 1.6e-06 22.2 In-house 157-235 (314) alignment 
Range on Protein: 261-339
Range on HMM: 157-235/314.0
YRVYNLCS-ERAYDPKHFHNRVSRIMIDDHNVPTLH-EMVVFTKEVNEWMAQDLENIVaIHCKGGKGRTGTMvCALLIASE
 |.....  .|... ..  ...  .   ||.||.    .. . ..|... ...  .|| .||  | |||||  .|. |  .
vrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGriv.vhCsaGaGrtGtf.iaidivld
subfamily_DSP11_pd Subfamily DSP11 268-358 2.2e-11 38.0 In-house 66-160 (178) alignment 
Range on Protein: 268-358
Range on HMM: 66-160/178.0
SERAYDPKHFHNR---VSRIMIDDHNVPTLHEMVVFTKEVNEWM--AQDLENIVAIHCKGGKGRTGTMVCALLIASEIFlTAEESLYYFGERRTNK
 .| |..|.....     ....  |.||. . .  |...|.|..   .| ......||  |  ||| ..|  ||  | .  .|...  | | |  .
tdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegy.epedaieafeearGhs
subfamily_RNGTT_pd Subfamily RNGTT 268-357 1.7e-09 31.7 In-house 64-156 (189) alignment 
Range on Protein: 268-357
Range on HMM: 64-156/189.0
SERAYDPKHFHN---RVSRIMIDDHNV-PTLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVCALLIASEIFlTAEESLYYFGERRTN
 .| || .....   .  .. .  . . |.  ..  | | |.|....  |.....||. |  ||| .... |.  | .  .|...  | . |  
tsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknpeevigvhCthGfnRtGFlivsyLvekedw.sveaavalFakaRpp
DSPc Dual specificity phosphatase, catalytic domain 273-364 8.1e-08 27.2 Pfam-A 34-123 (133) alignment 
Range on Protein: 273-364
Range on HMM: 34-123/133.0
DPKHFHNRVSRIMIDD-HNVPTLHEMVVFTKEVNEWmaQDLENIVAIHCKGGKGRTGTMVCALLIASEIFlTAEESLYYFGERRTNKTHSNKF
. |. ...  || ..| ..  .  |.   .. ...   .. .. |..||. |  |..|...| |. .. . ...| .... ||| .  .. .|
aikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknl.slneAyefvkerrskispnagf
DSPc Dual specificity phosphatase, catalytic domain 273-364 8.1e-08 27.2 In-house 34-123 (133) alignment 
Range on Protein: 273-364
Range on HMM: 34-123/133.0
DPKHFHNRVSRIMIDD-HNVPTLHEMVVFTKEVNEWmaQDLENIVAIHCKGGKGRTGTMVCALLIASEIFlTAEESLYYFGERRTNKTHSNKF
. |. ...  || ..| ..  .  |.   .. ...   .. .. |..||. |  |..|...| |. .. . ...| .... ||| .  .. .|
aikkseieylripvedetetkiskeleeavefieka..eqkgkkvlVHCqaGisRSatliiaYlmktknl.slneAyefvkerrskispnagf
PTPc_motif_SM00404 274-363 5.5e-06 21.3 In-house 42-129 (140) alignment 
Range on Protein: 274-363
Range on HMM: 42-129/140.0
PKHFHNRVSRIMIDD-HNVPTLHEMVVFTKEVNEWmaQDLENIVAIHCKGGKGRTGTMVCALLIASEIfLTAEESLYYFGERRtNKTHSN-K
 .. . .. .| .|| .. ......   .. ...   .. .  | .||. |  |..|...| |. ..  |...|..... ||| ..   | .
kensgfqilqiplddnekdklskyldkvldfiena..ekkggkvlVHCqaGvSRSatliiaYlmryrq.lslaeayefvkerR.piispnln
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 276-379 9.7e-07 23.1 In-house 171-266 (288) alignment 
Range on Protein: 276-379
Range on HMM: 171-266/288.0
HFHNRVSRIMIDDHNVPTLHEMVVftkEVNEWMaQDLENIVAIHCKGGKGRTGTMVCALLIASEIFLTAEESLyyfgERRTNKTHSNKFQGVETPSQNRY
 .   .     ||. ||  .   .    . | . ..|.. . .|.. | |||||..  |...  . |.   ..    ..  .|   ..|. ..|  |  |
vivkilhlleWdddgvPenylspl...rllevl.kslqkPivvhssaGvGrtgtlililialeslrlddflgi....rsllaklreerfkaiqtemqyly

VGYF
|   
vhrc
Y_phosphatase Protein-tyrosine phosphatase 276-340 3.1e-06 22.1 Pfam-A 134-197 (235) alignment 
Range on Protein: 276-340
Range on HMM: 134-197/235.0
HFhNRVSRIMIDDHNVP-TLHEMVVFTKEVNEWMaQDLENIVAIHCKGGKGRTGTMVCALLIASEI
.. . .      ||.|| . .... . ..|...  .. .. | .||. | |||||.|.. .. ...
ev.kqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql
Y_phosphatase Protein-tyrosine phosphatase 276-340 3.1e-06 22.1 In-house 134-197 (235) alignment 
Range on Protein: 276-340
Range on HMM: 134-197/235.0
HFhNRVSRIMIDDHNVP-TLHEMVVFTKEVNEWMaQDLENIVAIHCKGGKGRTGTMVCALLIASEI
.. . .      ||.|| . .... . ..|...  .. .. | .||. | |||||.|.. .. ...
ev.kqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql
subfamily_PTPRB_pd Subfamily PTPRB 280-333 2.7e-06 21.6 In-house 183-238 (293) alignment 
Range on Protein: 280-333
Range on HMM: 183-238/293.0
RVSRIMIDDHNVPTL-HEMVVFTKEVNEWMAQDL-ENIVAIHCKGGKGRTGTMVCA
.   .   ||.||   . .. |...|.|.. ..  .. . .||  | ||||| .. 
qyhftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfial
subfamily_DSP23_pd Subfamily DSP23 281-340 2.1e-10 35.5 In-house 54-111 (148) alignment 
Range on Protein: 281-340
Range on HMM: 54-111/148.0
VSRIMIDDHNVPTLHEMVVFTKEVNEwmAQDLENIVAIHCKGGKGRTGTMVCALLIASEI
. |. |||.  |.|...| | . |.|  |.. .. |..||  |.||||||.   |.  . 
lvrlriddyhppaleqvvefvrvvee..aeekneavsvhcllgrgrtgtmlacylvkerk
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 284-332 1.9e-06 22.2 In-house 178-227 (281) alignment 
Range on Protein: 284-332
Range on HMM: 178-227/281.0
IMIDDHNVP-TLHEMVVFTKEVNEWMAQDLENIVAIHCKGGKGRTGTMVC
.   || || | .|.. | |||..   .. .  . |||  | ||||| . 
taWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtGtyia
PTPc_DSPc_SM00012 286-343 1.6e-09 33.3 In-house 10-69 (105) alignment 
Range on Protein: 286-343
Range on HMM: 10-69/105.0
IDDHNVPT-LHEMVVFTKEVNEWMAQDL-ENIVAIHCKGGKGRTGTMVCALLIASEIFLT
. ||.||.  .... . ..|.... .   .. | .||. | |||||.|.. .. . .  .
wpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleke
subfamily_PTPMT1_pd Subfamily PTPMT1 291-355 6.1e-07 24.0 In-house 87-148 (171) alignment 
Range on Protein: 291-355
Range on HMM: 87-148/171.0
VPTLHEMVVFTKEVNEwmAQDLENIVAIHCKGGKGRTGTMVCALLIASEIfLTAEESLYYFGERR
 |.|...    . ...   ... . | .|||.|.||..|.| . |. .|  |. || | .  ..|
apdleklekgvefiek..vaskgkrvYvHCkaGrgRsatlvacylmkkek.lspeeAlkalkkkR
PTEN_C2 C2 domain of PTEN tumour-suppressor protein 391-520 5.8e-34 108.1 Pfam-A 1-133 (134) alignment 
Range on Protein: 391-520
Range on HMM: 1-133/134.0
PPRRILFIKRFIIYSI----RGDVCDLKVQVVMEKKVVFssTSLGNCSILHDIETDKILINVYDGPPLYDDVKVQFFSSNLPKYYDNCPFFFWFNTSFIQ
.....|..|..|...|     .. |..||.|...||.||  ..|.. .  .. .........  . |...||.|.|....  ...... | .|||||||.
ynpkrlelksiilegiPnfktrggckpkvkvyngkkkvf..kelasykdsterraktfivkepnrlpveGDvlveflhkdsklpkkekifrvwFNTsFie

--NNRLCLPRNELDNPHKQKaWKIYPPEFAVEILFG
  .|.|.||.||||...|.| .| ....|.||..| 
knqnvltlpkneLDkalkdk.dkkfsknfkvelvfe