Gene PTPN22 in Homo sapiens

Synonym: LYP, LYP1, LYP2, PEP, PTPN8, PTPN22

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN12
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP074_AA protein Get Run
HsapP074_AA_22-291 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 3-290 1.4e-48 160.1 In-house 10-283 (290) alignment 
Range on Protein: 3-290
Range on HMM: 10-283/290.0
QREILQKFLDEAQSKkiTKEEFANEFLKlkrQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSlitSDEDSSYINANFIKGVYGPkaYIAT
| | ..||  .. .|  . .|.| |.|.   .   |   . .   . .|  ..|||||||.   | .|| |.      |  |. ||..||.  .  .| |
qteafekfasdvvkk..nvdelakeyle...klkpylpvqylerkifdkntefkknrykdvvcndktrvilk...dGydGdyvhanyvkGlkam..filt

QGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYI-IRTLKVKF--NSETRTIYQFHYKNWPDHDVP
||.|  | .|.|||. .  |  ||| |   | || |||.|. |     | || ..| |  |. | . |  .|| |.   .     .. .. | |||. |.
qGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksva

SSIDPILELIWDVRCYqeddSVPICIHCSAGCGRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF
 |   .| ..  .|      | |. .||||| |||| . ||. .  .| ||    .. .  |.| .|  | . || . || .. ...|.| 
lstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglqilldG...keldlldlvralrnsrlnsvqvdiqylalveilldlG
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 6-291 5e-76 250.8 In-house 13-291 (298) alignment 
Range on Protein: 6-291
Range on HMM: 13-291/298.0
ILQKFLDEAQSKKITkeEFANEFLKLKRQSTKYKADKtypTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGP
 |||. .  ..||.|   .|.|| .|.. | . ....   ..||.||.| ||||| ||...|.||| |. . .||.| |||| |...  | .|.||||.|
alqklaavkkkkklt..gyalefqrlnsvsseieeee...kevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaP

LSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWaePGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKF--NSETRTIYQFHYKNWPDHDVPSSID
| .|. |||||..|. .  |||     |..| |...||  | | . ..| ..||  ......|.|.|.|||.   ....|.. |.|. .|||..||.   
ltetvedFWrmvteedigtiVmltnleeldktkyhkyw..PdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenat

PILELIWDVRCYQEDDS-VPICIHCSAGCGRTGVICAIDYtwmLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
 .|.|. .|| .|..   .|. ..|||| ||.|  .|||    .|    . .   ||  .. .|..|| .|||.|||  .|.|||| ..
svldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaids...vlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 7-290 1.3e-50 167.1 In-house 7-279 (439) alignment 
Range on Protein: 7-290
Range on HMM: 7-279/439.0
LQKFLDeaQSKKITKEEFANEFLKLKRQSTKYKADKTYpttvAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPL
.|. ..  . .|  .| | ..| |..  | .|... .     | .  .  ||||||. ..|..|| |  |     | |||||.||| | .| ||||||| 
fqehve..kldknkqeifkeifekinstspdyaciasl....aaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpk

STTLLDFWRMIWEYSVLIIVMACMEYEMGKkkcerYWaePGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS----ETRTIYQFHYKNWPDHDVPSSI
  |  ||||...|  .  ||| .   |  |     ||  | . .  .|  .| .. .    .|.|| .||  .       ||. ||||  |||..||.  
kettddfwrlviekktvtivmltnlvesyk.....yw..psdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqa

DPILELIWDVRCYQ-EDDSVPICIHCSAGCGRTGVICAIDYTWMLLKdgiIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF
  .|...  .   . ...  |. .||||| |||| | |.| .   ||   . ..  .  ... .| ||  .||.  || ..||||||  
shvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlk...lenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 8-293 1.9e-38 126.9 In-house 10-290 (305) alignment 
Range on Protein: 8-293
Range on HMM: 10-290/305.0
QKFLDEAQSKKitKEEFANEFLKLKRQSTkYKADKTYpttvaEKPKNIKKNRYKDILPYDYSRVELsliTSDEDSSYINANFIKGVYGPKAYIATQGPLS
 ||....  |    . . .||  .||    ..  |..      . .. .||||||.   |  || |    .     || ||..     || .| || || 
lkfvkrtlekg..paglraefvamkrfnd.fekmkaf.....keaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaple

TTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFG----PFSVSCEAEKR-----KSDYIIRTLK--VK-FNSETRTIYQFHYKNWPD
 |  ||| | ..  |  | | |   | | |||  |.|   . .|||       || .|. ..     ...  ..  .  ..   ...| . ..|. .|||
ktcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpd

HDVPSSIDPILELIWDVRCYQeddsVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSvfSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQ
  ||..   ||||. . |  .     || .||||| |||| .  ..|    |  | | |.     ... .| ||   .||..|| .|.. .|. |...
rgvpaadlailellekarpsk....gpivvhcsagigrtgsvvmleyildqllagqiiedtd..kilqkireqrnnsiqtdaqylfvhqvilnyfrkk
subfamily_PTPN6_pd Subfamily PTPN6 12-294 3.6e-78 257.6 In-house 17-301 (306) alignment 
Range on Protein: 12-294
Range on HMM: 17-301/306.0
DEaQSKKITKEEFANEFLKLKRQSTKYkadkTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSlITSDEDSSYINANFIKGVY--GPKAYIATQGPLSTT
.. ......|. | .|| .|... .|.    ..  . ..||.| .||||| |||.| .|| |.   |  .| |||||.||.      |.|||||| |.||
ek.eeeslekagfeeefeelqqeeakk....llsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclett

LLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLeFGPFSVSCEAEKRKSDYIIRTLKV---KFNSETRTIYQFHYKNWPDHDVPSSIDPIL
. |||||.|. .  .|||. .|.| ||.|| ||| .  | .  .|  ||.. .||...|||.|.|.|   |...|.|...|.|.|.||||.||.. . .|
vsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavL

ELIWDVRCYQEDDS----VPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQM
... ||.  ||. .     ||..||||| |||| .  ||    |..   .  .. . .|.. .|.||  ||||..|| .||.|. .  ... 
dfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 14-290 1.7e-59 196.1 In-house 12-278 (287) alignment 
Range on Protein: 14-290
Range on HMM: 12-278/287.0
AQSKKITKEEFANEFLKLKRQsTKYKADktypTTVAEKPKNIKKNRYKDILPYDYSRVELSlitsDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDF
|. ..  .|.| | |  |..  |. . .     |..  ..| .|||...||..|  || |     .|.  |||| ||.|    ||.|....|.. |. .|
akghakgnegfknqftvleqv.tqrede....vthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnf

WRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEmqLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS---ETRTIYQFHYKNWPDHD-VPSSIDPILELI
|..|..  | .||| | | |  ...| .||.|     . .|.....   |.....||.|.|.|| ..   ..... |... ||...  |..    .| . 
WkliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvie

WDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLL-KDGIIpenfSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF
  ..  .     .| .|||.. ||... ||.. |     ..|.|     ||......| |.|  ||| |||. ....|||  
emyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGvi....Dvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Ptp69D_pd Subfamily Ptp69D 15-292 4.4e-74 244.4 In-house 15-288 (307) alignment 
Range on Protein: 15-292
Range on HMM: 15-288/307.0
QSKKITKEEFANEFLKLKRQstkyKADKTypTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFW
..|. |.. .|.|. ||...    . ||.  |.|.||  |  ||||.|| ..|  || |. |. .|||.||||.||||    | .|| |.|. .|. |||
srkrdtdfglakeyekLear....eidks..tkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfW

RMIWEYSVLIIVMACMEYEMGKKKCERYWAEPgeMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS-------ETRTIYQFHYKNWPDHDVPSSIDPILE
|||.| .| .|||   . |. .|||..||..    . ..|   | .  |...||||||.|.|  .        ..| . |.||..|.|  || .   .|.
RmiaeqevtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllk

LIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDgiiPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKR
||  ||  .. .  || .||||| ||.|.. |.|  .  ||     .. ..|  ....| ||. |||  |||. .| |.|.  . 
lieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlka...edkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 15-289 2.4e-46 152.6 In-house 4-268 (281) alignment 
Range on Protein: 15-289
Range on HMM: 4-268/281.0
QSKKITKEEFANEFLKLKRQSTkykADKtypTTVAEKPKNIKKNRYKDILPYDYSRVELSL-ITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDF
 |.|.| ..| .|| .|  .     .|     || ..| | ||||| .|   | |||.| . .   . . || ||.|.  .  . || ||||   |  ||
ssqkmtlddfkqefsnlpgdpp...sdl...ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradf

WRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVR
|||||.     ||| |   |  ..||  |.       |.|  .||| |    .   .   |.. .. ||| | .. .|.||| .|| | . .|...  .|
wrmiwqenttaivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir

CyqedDSVPICIHCSAGCGRTGVICAIDYTWMLLKD-GIIPENFSVFSLIRemRTQRPSLVQTQEQYELVYNAVLEL
.     | |  |||||| ||.| . |.. .   ..    .|.   . | .|   | | . ||| .|| |... .|..
a....rstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlr..vtgraasvqtlqqymliwkvlldf
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 16-291 2.7e-75 248.1 In-house 15-280 (288) alignment 
Range on Protein: 16-291
Range on HMM: 15-280/288.0
SKKITKEEFANEFLKLkrqstkYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWR
 .. ....| .|. .|       . .||  .|......| |||||..|||||. ||.|      ... ||||..|.|  . |.||||||||  |. |||.
ksarnrtgfseeynsL......aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQlEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCY
...|. .  |||     | ||.|||.|| . .. . ..| . |    .| . |.. |.| .. . . ..| |..|. ||||.|| |  |.|||.  |   
lvyenktstivmltelveggktkCeeYWPdadkpk.nyGsvtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkva

QEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDgiiPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
...|. || .||||| ||||.  |.|     ..     .   |.. . ..| ||..||||..||| .|...|.| .
nqadtgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllslie
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 16-291 9.8e-64 210.0 In-house 14-284 (290) alignment 
Range on Protein: 16-291
Range on HMM: 14-284/290.0
SKKITKEEFANEFLKLKRqstkykADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDED--SSYINANFIKGVYGPKAYIATQGPLSTTLLDF
 ..  .| | |.| .|.       ... . .||.  ..| ..||...|..||  |. |  |....|   .|||| .|||    |.|||||||.| || ||
ghakgnegfrnqfkmlds......gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdF

WRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPgEMQLeFGPFSVSCEAEKRKSDYIIRTLKVKFNSE---TRTIYQFHYKNWPDHDVPSSIDPILELIW
|..||. .| |||| . . |.||.||  ||..  . .  .|.||.    |.  ..||.|.|.|| ...   .... |.. .||....       || .| 
WkliwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvie

DV-RCYQEDDSVPICIHCSAGCGRTGVICAIDYTwmlLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
 . .    .   .| .|||.. ||..| ||.. |   ..   .     ||......|.|.| .|||..||..... ||. ..
emyktqrkrgntsivvHCSdtvgrsavfcaaatt...inkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_PTPN12_pd Subfamily PTPN12 17-302 2e-142 468.3 In-house 3-289 (290) alignment 
Range on Protein: 17-302
Range on HMM: 3-289/290.0
KKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRM
.| ..||||.|| |||..|.||||.|.|.|...||..|.||||||||||||.|||||| |...|.|.||||||||||.|...|||.||||..|| |||||
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrm

IWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKS-DYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCY
|||..| |.||||.|.|.|||||||||.| ||..||||.|.|..|.||. . |..||||||....|.|..|||||..||||.||||....||||..||..
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrel

QEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDKHS
||....|...|||||.||||.|.||||...|||...|||...||.|..|.|.||..||||.|||||||.||.||.......|..|.|
qesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiieekks
0047943 (Phosphotyrosine protein) phosphatases II 17-290 9.9e-91 299.3 In-house 7-272 (273) alignment 
Range on Protein: 17-290
Range on HMM: 7-272/273.0
KKITKEEFANEFLKLKRQSTkykadkTYPTTVAEKPKNIKKNRYKDILPYDYSRVELslitSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRM
|.  .  .. || .|... .       ....||..|.|..|||||||||||.||| |    .|..|.||||....| . ....|||||||. |. |||||
kllgltllleefelllslkp......lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrm

IWEYSVLIIVMACMEYEMGKKKCERYWAEPGEM-QLEFGPFSVSCEAEKRKSDYIIRTLKVKF--NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVR
.||. | .||| . ..|.|..||..|| . |.   |..|.|.| .  |. |.||..|||....  ..|.||...|||..||||.||.|....||.|..||
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvr

CYQED--DSVPICIHCSAGCGRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF
 ..|   .. |...|||||.||||...|.|. . .|. .    ...|..... .|.|||  ||| |||...|.|.||..
kalealpsngpvvVHCsaGvgRtgtfialdllldqleke...ggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN13_pd Subfamily PTPN13 17-292 7.5e-69 227.0 In-house 6-271 (273) alignment 
Range on Protein: 17-292
Range on HMM: 6-271/273.0
KKITKEEFANEFLKLKRQstkyKAdkTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSlitsdEDSSYINANFIKGVYGPKA--YIATQGPLSTTLLDFW
||. ... |.|| .|.      |.  .  ..|..| .| .||||...|||| .||.|.     ....||||..||   | .   |||.|||| .|  |||
kkldqqqPaeefkelrel....kp..ldtcevgkkkenkdknryrnvlPydetrvklg.....deggyinaslikvpvgkdeyeyiacqGPlPetvkdfw

RMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGP-FSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSIDPILELIWD
.|.|| .. .|.|  .| | || ||.||| |  . .|     . |. .  ...... .|.|.|| .  .|.| . .... .||||.|||| ...|...  
qmvweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvae

VRCYQEdDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIipeNFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKR
||  |. |. || .||||| ||.|.. .||    |..      .| |  ..|..| || ..|||..|| .||.|.||..|.
vrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 17-293 1.3e-62 207.0 In-house 22-296 (319) alignment 
Range on Protein: 17-293
Range on HMM: 22-296/319.0
KKITKEEFANEFLKLK---RQSTKYKADKTyPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDF
.. .|..| ..  ||.   |. .|  .. .   | |. ..|  |||. .||..| ..| |  .   | | |||| |..|   .. |||.||||  || ||
qlsnksdfdddltklevefrracklgvnla.dqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladf

WRMIWEYSVLIIVMACmeyemgKKKCERYWaePGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKF---NSETRTIYQFHYKNWPDHDVPSSIDPILELIW
||||||| .  ||.        |.|| .||  | ... . . | |. .. .  ..|..| ...     . . | | |||.. |||. || .  ... |. 
Wrmiweyncstivllt......kdkcsqyw..plkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvk

DVRCY--QEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE--LFKRQ
 ||    .|..  .| .|||||.|||||  ..|     .|.    .   |. ..|..| ||. |||   || ..| |.||  || . 
kvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghs
0050432 (Phosphotyrosine protein) phosphatases II 18-294 3e-94 311.1 In-house 38-303 (308) alignment 
Range on Protein: 18-294
Range on HMM: 38-303/308.0
KITKEEFANEFLKLKRQSTkykadkTYPTTVAEKPKNIKKNRYKDILPYDYSRVELslitsDEDSSYINANFIKGV--YGPKAYIATQGPLSTTLLDFWR
.. .  .  || .| .. .       ....||..|.|..|||||||||||.||| |     ||.|.||||....|   . |...|||||||..|. ||||
aldlglleeefeellsvkp......lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwr

MIWEYSVLIIVMACMEYEMGKKKCERYWAEPGE-MQLEFGPFSVSCEAEKRKSDYIIRTLKVKF--NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDV
|.||. | .||| . ..|.|..||..|| .  .   ||.|.|.| .  |. ..||..|||....  ..|.||...|||.|||||.||.|....|.... |
mvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelv

RCYQedDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQM
| ..  .. ||..|||||.||||...|.|. . .|. .    ...||.... .|.|||  ||| |||...| |.||..|. .
rksl..pggpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0045450 (Phosphotyrosine protein) phosphatases II 18-291 8.2e-90 296.9 In-house 19-305 (307) alignment 
Range on Protein: 18-291
Range on HMM: 19-305/307.0
KITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSD-EDSSYINANFI--------KGVYGPKAYIATQGPLST
.... .| . .||  ..  ... .  .....|..|.|..|||||||||||..|| || .... |||.||||...        .| . ....|||||||. 
llllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpe

TLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPgEMQLEFGPFSVSCEAEKRKSDYIIRTLKVK---FNSETRTIYQFHYKNWPDHDVPSSIDPI
|. |||||.||. | .||| . . |.|..|| .|| .  . .|..|.| | .  |. ...|..|||.|.   ...|.||...|||..||||.||.|....
tvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeel

LELIWDVRCYQED--DSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
|..|  || ..|.  .. |...|||||.||||...|... . .|... . ....... ....| |||  ||..|||. .|.|.|||..
ldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 18-295 3.8e-19 63.2 In-house 22-290 (302) alignment 
Range on Protein: 18-295
Range on HMM: 22-290/302.0
KITKEEFANEFLKLkrQSTKYKADKtyPTTVaekPKNIKKNRYKDILPYDYSRVELSlitsDEDSSYINANFIKGVYGPKAYIATQGPLSTTL---LDFW
.... |  .|| |.  ...| ...|   ..     ||.|||. .|.  .|  .| |.     |  ||.||  ..     .  | .| | ...     .||
sldtaevkkefkki..dtmkvdlek..Ckaf...kknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFW

RMIWEYSVLIIVMACMEYEMGKkKCERYWAEPGEMQLEFGPFSVSC----EAEKRKSDYIIRTLKVKF-NSETRTIYqfHYKNWPDHDVPSSIDPILELI
||... ..  .|.. .| |. |   . .. .  .  .|.| . |      .||. |. |.|  |   . ||   ..|  . .||... || ..  . . .
rmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvy..vltnWkqkkvpvkyaelikta

WDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMD
 .|   ... . .. |    |.|| |.. .   .   |..|   ..  .  ... .|.|||. |.. .||  .| |.| ..|... 
akvfakkikadentvivSknGaGRagafltlavaveklqkg...kepnikeivksiRsqRpravdslkQyvslyialllyikkkvt
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 19-291 1.2e-78 259.4 In-house 20-284 (319) alignment 
Range on Protein: 19-291
Range on HMM: 20-284/319.0
ITKEEFANEFLKLKRQSTKykadktyPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIW
 ..  ...|| .||  ...        .. |.|..| |||||..||.|| .|| || .   |.| ||||.|| |    ...||||.||..|. |||||.|
tgetllekefkllkeavnd.......tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvW

EYSVLIIVMACMEYEMGKKKCERYWAEpgEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS---ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCY
|. . |.|| .   | .| |...|| |  |   |.| . |  | |....||||| ||.. .|   |||.. .|.|..||||||| .   .|.|. ..|  
eeessivvmltklveklkvklkkywpe..enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirks

QED-DSVPICIHCSAGCGRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
.|  .| || .||||| ||||  ...| .   .|     .   ||| ....||||. .||..|||...|.|.||  .
rektqsgPivvhCsaGvGRtGtfivldamlervkee...gvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_PTPN9_pd Subfamily PTPN9 20-291 2.3e-68 225.4 In-house 14-291 (297) alignment 
Range on Protein: 20-291
Range on HMM: 14-291/297.0
TKEEFANEFLKLKRQSTKYKADKtypttvAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWE
 |.   .|.......... ....      .... |..||||.|.| || .|| |. .  || | ||||||. |   .||.|||||||  |  |||||.||
gkrGlskeyaeirnepveGtfla......sklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWe

YSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVK--FNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQE
 .||.|||.    |.|. || .|| .  | . ||| .|||    . ..|| .|.|..|   ..|.|..  | .  |||. ||||   .|...  || .| 
qevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqa

D-------------DSVPICIHCSAGCGRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
              .  || .||||| ||||  ...|..   |..    ..  |.  .. .||||   .||.||||. | ||||  .
lavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleev...gtvdvvetvkllrtqrafsiqtpeqyefcylavleyal
subfamily_PTPN23_pd Subfamily PTPN23 20-293 1.2e-59 196.5 In-house 13-283 (288) alignment 
Range on Protein: 20-293
Range on HMM: 13-283/288.0
TKEEFANEFLKLKRQSTKYkaDKTYPTTVAEkpKNIKKNRYKDILPYDYSRVELSlitsDEDSSYINANFIKGVY-GPKAYIATQGPLSTTLLDFWRMIW
 | .. ..| .|...  |    .   ...|.  .. .|||..|||||| .|| |     ..   |||| |.|..  |   .||||.|| .|| |||.|..
gktaldkkfkeleqkqdke..arkrsiaiak..lyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvy

EYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRC--
|  . .|||   . |.||.|..||| |  .   .||..||... ... . .. |.||....  ......   ....||.. ||.| . .|...  |.   
eqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesay

--YQEDDSVPICIHCSAGCGRTGVICAIDYTWMLL-KDGIIPenfSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQ
   |.   .|. .||||| |||||.. .      | |. ...    .  ... .|.||   ||..||.. .|.||||  .| 
eavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgngll...diiqvvsrlreqRrfmvqekeqlkfsyeavleaarrv
subfamily_PTPRB_pd Subfamily PTPRB 21-294 1.4e-79 262.2 In-house 24-289 (293) alignment 
Range on Protein: 21-294
Range on HMM: 24-289/293.0
KEEFANEFLKLKrqstkyKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEY
. .|..|. .||      . .|.  ...||...| .||||..|||||.|||.|. ......| |||||.|.|   |. .||||||| .|. |||||.|| 
dlrfseeyeelk......avgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwek

SVLIIVMACMEYEMGKKKCERYWAEpGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQ--ED
 . ||||     | ||.|||.|| .  | .  .|  .|.  ||....|..||.||.. ..|.|.. |.|.. ||||.||.. ...|...  || ..  . 
kssiivmltqlvekgkvkCeeYWPa.deepvlyGdikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiekta

DSVPICIHCSAGCGRTGVICAIDYTWMLLKDgiiPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQM
.. || .||||| ||||.  |.|     ...    .   .|... |.|..| .||||..||  ....||.|.....
skrPivvhCsaGvGRtGtfialdrllqaiee...edyvdifgivaelReeRnllvqtekqYifihqcvldllrkke
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 21-291 7.4e-79 260.1 In-house 19-281 (318) alignment 
Range on Protein: 21-291
Range on HMM: 19-281/318.0
KEEFANEFLKLKRQSTKYKAdktyptTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEY
. .. .|. .|.|.. .  .      . . .| | .|||| .||.|| .||.|. ....|.| |||||.| |    |||||.|.||. |. |||||.|| 
elllseeyerlsrseetvts......lkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeq

SVLIIVMACMEYEMGKKKCERYWaePGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN--SETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQ-E
   .|||   | | ||.|..|||  |..   ..|   |  . |.. |||..|..||. .  .|.|.. |.|| .|||..||.|   .|.|. .|. .| .
nsavivmltqeeergkakvhryW..PskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqk

DDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
 .  || .||||| ||||| .|.|     .|.    .   ||  ....|.||. .|||..|||..|...||  .
sgagpivvhCsaGvGrtGvfiavdillerikae...alvDvfqtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 21-293 1.3e-49 163.5 In-house 9-280 (287) alignment 
Range on Protein: 21-293
Range on HMM: 9-280/287.0
KEEFANEFLKLKRQStkyKaDKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSlITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEY
|..  .|. .||. |   .   |.    ||.  ..||||| |.||.| .|| ||  ...  |.|||||.. .    .|.||.|||...|. ||||...| 
kddvdkevdalkeds...e.sstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravlet

SVLIIVMACMEYEMGKKKCERYWAEPgEMQLEFGPFSVSC-EAEKRKSDYIIRTLKVKF-NS-ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCY--
 .  ...   | | ...|| .|| |. |. .  | .||   . .... .| .|.|..   .. |.| . |... .|||. .. .   .. .. ||. .  
rsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhie

---QEDDSVPICIHCSAGCGRTGVICAidyTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQ
   . ..  |. .|...| ||.|.. |   |..|.. .    .  |   .  .| .| .|||.  |. |.|.|.   .| .
lardasevGPlvvhddvGiGrsGilla...tlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyktn
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 21-288 5.3e-37 122.3 In-house 5-257 (267) alignment 
Range on Protein: 21-288
Range on HMM: 5-257/267.0
KEEFANEFLKLKRQSTKykaDKTYPTTVAEkpKNIKKNRYKDILPYDYSRVELSLITSDedssYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEY
. |. .|| ..|. |..     |  . .||  || ..||. | |||| .|| |.  . .    |||| ...| .  .|.|.||.||. |  ||. .| ..
eceiekefelikkisdt...sstisqsiae..knqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdq

SVLIIVMACMeyeMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSET-RTIYQFHYKNWpdhDVPSSIDPILELIWDV--RCYQE
 | .||.  .    .. .  ..|        ..  ..|    || . || | ||..||. |. . .  ..||.|   .. .   | |. .. .  .   |
kvpvivlltk...vftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknesahnvtlyyykkw...nintnnkpylkplfgilaknqle

DDSVPICIHCSAGCGRTGVICAIDYTWMLLKDgiiPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
. . |. ..||.| ||.|    ||     .|     .   .| ..|..| ||..||.|.|.|  ... . |
ngnrPlvvacsdGvGrsGtflvidsqlerakt...egvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 21-104 1.1e-11 38.7 In-house 22-95 (95) alignment 
Range on Protein: 21-104
Range on HMM: 22-95/95.0
KEEFANEFLKLKRQSTkykadKtyPTTVAEKPKNIKKNRYKDILPYDYSRVELsliTSDEDSSYINANFIKGVYGPKAYIATQG
 .|| |||  .   |         | ||     || |||. .|.||| .|| |   |.  || |||| |. |    ..|||.||
dqefdnefksismtsg.....a..pytvgsseanipknrflnifpydatrvvl...ttkrdsdyinacfvdgyarkncyiaaqg
0039614 (Phosphotyrosine protein) phosphatases II 22-294 1.8e-87 288.8 In-house 32-293 (297) alignment 
Range on Protein: 22-294
Range on HMM: 32-293/297.0
EEFANEFLKLKRQSTkykadktyPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITS-DEDSSYINANFIKGVYG-PKAYIATQGPLSTTLLDFWRMIWE
  . .|| .|...          ....|..|.|..|||||||||||.||| |. . . |.||.||||....| .  ....|||||||. |. |||||.||
tllllefeellslkp........dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

YSVLIIVMACMEYEMGKkKCERYWAEPGEmqlEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQED-
. | .||| . . |.|. ||..|| | |.   ..|.|.| .  .. ...|..|||.|. |.|.||...|.| .||||.||.|.. .||..  || ...  
qgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvrealael

-DSVPICIHCSAGCGRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQM
 .. |...|||||.||||...|... . .|. .    ...|.. ..|.| |||  ||| .||. .|.|.|||.|| .
pkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_PTPRG_pd Subfamily PTPRG 22-314 4.5e-70 231.5 In-house 19-308 (563) alignment 
Range on Protein: 22-314
Range on HMM: 19-308/563.0
EEFANEFLKLKRQStkykADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDS-SYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEY
  |..|| .|....    ..|. ... ..||.| .|||| .|..|| |||.|| ..  ...  |||||.|.| .  ||.||||||| .|. |||||||| 
igfseefealqset....iskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeq

SVLIIVMACMEYEMGKKKCERYWAEpgEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKF-----NS---ETRTIYQFHYKNWPDHDVPSSIDPILELIWDV
 | ||||     | |..||..|| .  .  ...| ..|  ..|.... | .|||..|      ..   . ....|.|| .||||.||..  | |  .   
nvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks

RCYQEDDSVPICIHCSAGCGRTGVICAIDytwMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDKHSgteSQAKHCI
   ....  || .||||| ||||. ...|    |||.    .   || ... .|.||. ||||.|||  ...|.||. . . . . ...     . | | 
saankaeaGPivvHcsaGvgrtGtyivld...tllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqv...eelknct

PE
| 
py
0049772 (Phosphotyrosine protein) phosphatases II 22-297 2.8e-46 154.0 In-house 16-287 (314) alignment 
Range on Protein: 22-297
Range on HMM: 16-287/314.0
EEFANEFLKLKRQSTKYKADKTypTTVAEKPKNIKKNRYKDILPYDySRVELSLITSDeDSSYINANFIKGVygpKAYIATQGPLSTTLLDF--------
... ...|.|.| |  .  ..|  ..|| ...|..||||.||||.| .|| |.    . .|.||||....|.   ...|||||||. |. ||        
ddllklllvlnrrslsvlpelt..ilvadlflnrdknryldilpad.nrvilpglpvs.gsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyy

--WRMI--WEYSVLIIVM-----------------------ACMEYEmgkkkceRYWAEPGEMQLEfgpfsvsceaeK-------Rksdyiirtlkvkfn
  |||.  ... | .|||                        ....         .. .    .|.           .                      
ngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.......neptaadlellk...........eelydpelf..............

seTRTIYQFHYKNWPDHDVPsSIDPILELIWDVRCYqeDDSVPICIHCSAGCGRTGVICAIDYTWMLLkdgiipeNFSVFSLIREMRTQRP-----SLVQ
  .|....... ..||...| ... ..|..  .. .  |.  |. .||.||.||||. ....|  .||       ..|.   ....| .||     ....
..erlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll.......gvsleealedvrlkRpinpnpgfie

TQEQYELVYNAVLELFKRQMDVI
..|||| ...|.||..|......
qleqyefilealleylkflkkfy
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 22-292 3.8e-38 125.8 In-house 24-291 (305) alignment 
Range on Protein: 22-292
Range on HMM: 24-291/305.0
EEFANEFLKLKRQStkyKADKTYPTTVAEKPK--NIKKNRYKDILPYDYSRVELSlitSDEDSSYINANFIKGVYGP-KAYIATQGPLSTTLLDFWRMIW
. . .|| .| . .   . | |  .  |..    .| ||||.|.   | | | |.       | || ||..     | | .|..||||  |. .|| |. 
dklreefrglakyt...rpdmtqvafnanqsadiaitknryqdvpcqdqsavkld...kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmvi

EYSVLIIVMACMEYEMGKKKCERYWAEP-GE-MQLEFGPF--SVS-CEAEKRKSDYIIRTLKVKF-NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDV
.  |  ||| |   |.|| || .||    || ..|  |     || .   .| ..  | .|.. .  ... .. .... .|||  ||      |||.  .
qnkveqivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai

RCYQeddsVPICIHCSAGCGRTGVICAIDYTWMLLKDGiiPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKR
|  .    ||| .||||| |||| | ||.|    . .    .   .  |.. .| ||   .|.. ||  ..  .|. |  
rgsk....vpivvhcsagigrtgtivaieyilekiaen..kpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfle
0040438 (Phosphotyrosine protein) phosphatases II 23-302 2.4e-93 308.2 In-house 19-288 (317) alignment 
Range on Protein: 23-302
Range on HMM: 19-288/317.0
EFANEFLKLKRQstkykadKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSV
 . .|| .| ..       | ....|||.|.|..||||.||||||.||| || ...|.||.||||....| . ....|||||||. |. |||||.||. |
alleefedllsl.......kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgv

LIIVMACMEYEMGKKKCERYWAEpgEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKF--NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDS
 .||| . . |.|..||..|| .  .  |..|.|.| .  |. ......|||.|.   .||.||...|||..||||.||.|.|..|...  || ..||..
tvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpg

VPICIHCSAGCGRTGVICAIDYTWMLLKDGIipeNFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDKHS
 |...|||||.||||...|... ...|. .    ...|.. ..|.| |||  ||| |||. .| |.||..|| .  . ... 
gpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepasel
0046845 (Phosphotyrosine protein) phosphatases II 24-295 1.4e-94 311.9 In-house 2-279 (284) alignment 
Range on Protein: 24-295
Range on HMM: 2-279/284.0
FANEFLKLKRQSTKykadKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSD-EDSSYINANFIKGV-----YGPKAYIATQGPLSTTLLDFWRMI
.  || .| .. .|     .....|| .|.|..|||||||||||.||| |. . .| |||.||||....|      | .|..|||||||..|. |||||.
leeefeellsltvk....lllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmv

WEYSVLIIVMACMEYEMGKKKCERYWAEPgEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKF---NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRC
||. | .||| . . |.|..||..|| .  .  |..|.|.| .  |. |.||..|||....   ..|.||...|||..||||.||.|....||....|| 
weqnvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvre

YQE--DDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMD
..|  ... ||..|||||.||||...|.|. . .|. . .. ...|..... .|.|||  ||| |||..||.|.||..|. . 
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
0051299 (Phosphotyrosine protein) phosphatases II 24-291 3.1e-94 310.9 In-house 25-287 (288) alignment 
Range on Protein: 24-291
Range on HMM: 25-287/288.0
FANEFLKLKRQSTKykadktYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVL
...|| .| .. ..      .....| .|.|..||||.||||||.||| || . ..|.|.||||..|.| . ....|||||||..|. |||||.||. | 
lleefeellsllpd......ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFWrmvweqnvr

IIVMACMEYEMGKKKCERYWAEpgEMQLEFGPFSVSCEAEKRKSDYIIRTLKVK------FNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQE
.||| . ..|.|..||..|| .  .  |..|...| .  |. ..||..|||.|.      ...|.||...|||.|||||.||.|....|... .|| ...
vIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

DDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
... |...|||||.||||...|.|. ...|. .   . ..|..... .|.||| .||| |||..|| |.||..|
sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk
subfamily_PTPRD_pd Subfamily PTPRD 24-299 1.1e-91 303.2 In-house 18-290 (564) alignment 
Range on Protein: 24-299
Range on HMM: 18-290/564.0
FANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVL
 ||. ||....  | .  .. ....|.|| | .||||..|..|| ||| || .  ||.| ||||.||.|   .||||||||||..|. |||||.||. . 
kansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnss

IIVMACMEYEMGKKKCERYWAEPgEmQLEFGPFSVSCEAEKRKSDYIIRTLKV--KFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSV
.|||     |.||.||..|| |  . . ..| . |. |.|....||.|||.|.  | .||.|.. |||. .||||.|| |  ..|.|| .|| ..|.|. 
tiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdag

PICIHCSAGCGRTGVICAIDYTWMLLKDgiiPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRD
|| .||||| ||||. ..||. .  .|.    ..  ... ....|.||. .|||.|||  ...|.||  . . . .. 
PivVhCSaGVGRTGtfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnteves
0043336 (Phosphotyrosine protein) phosphatases II 24-290 8.1e-88 289.7 In-house 15-277 (278) alignment 
Range on Protein: 24-290
Range on HMM: 15-277/278.0
FANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVL
..|.. .|...  ..   |......|..|.|..|||||||||||.||| |||...|.||.||||....|   |...|||||||. |. |||||.||. | 
llnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetvedFwrmvwelgvt

IIVMACMEYEMGKKKCERYWAepgEMQLEFGPFSVSCEAEKRKSDYIIRTLKVK--FNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSV
.||| . . |.|..|| .||    .  |..|.|.| .  |. ..||..|||.|.   ..|.||....||..||||.||.|....|.....|| ..||.. 
tivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsng

PICIHCSAGCGRTGVICAIDYTWMLLKDGIipeNFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF
|...|||||.||||...|... ...|...    ...... ..|.|.|||. |||..||. .|.|.||..
pvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealleyl
DSPc_SM00195 26-291 1e-90 299.0 In-house 4-263 (263) alignment 
Range on Protein: 26-291
Range on HMM: 4-263/263.0
NEFLKLKRQSTKYkadktyPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLII
.|| ||... ..       .|| |||.|| .|||||.||||| .||.|. . ..|.|.|||||.|||   .|.||||||||..|. |||||.||  | ||
eefekleestspk......etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkii

VMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKS-DYIIRTLKVKFNS--ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVP
|| ..| | ||.||.||| |  . . .|| .|| .  .. |. ..|.|||.....   |||...|..|||||||.||.| ...|||.  |.  ..  |.|
vmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

ICIHCSAGCGRTGVICAIDYTWMLLKDGIIpenFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
|..|||||.||||....||. .  |...     ...|....|.|.|||..|||.|||  .|.|.||..|
ivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyik
PTPc_SM00194 26-291 1e-90 299.0 In-house 4-263 (263) alignment 
Range on Protein: 26-291
Range on HMM: 4-263/263.0
NEFLKLKRQSTKYkadktyPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLII
.|| ||... ..       .|| |||.|| .|||||.||||| .||.|. . ..|.|.|||||.|||   .|.||||||||..|. |||||.||  | ||
eefekleestspk......etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkii

VMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKS-DYIIRTLKVKFNS--ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVP
|| ..| | ||.||.||| |  . . .|| .|| .  .. |. ..|.|||.....   |||...|..|||||||.||.| ...|||.  |.  ..  |.|
vmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

ICIHCSAGCGRTGVICAIDYTWMLLKDGIIpenFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
|..|||||.||||....||. .  |...     ...|....|.|.|||..|||.|||  .|.|.||..|
ivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyik
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 27-291 1.6e-69 229.3 In-house 26-285 (297) alignment 
Range on Protein: 27-291
Range on HMM: 26-285/297.0
EFLKLKRQSTkyKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGpkAYIATQGPLSTTLLDFWRMIWEYSVLIIV
.. . ... .   . ...|.|||||  |..|.|||.||||| |||.|  . .| || |.|| |.||.     .|.|| |  .|. |||.|.... | .||
dvfseeflcl..peaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstiv

MACMEyEMGKKKCERYWAEPGEMQleFGPFSVSCEAEKRKSDYIIRTLKVKFNS--ETRTIYQFHYKNWPDHDVPS--SIDPILELIWDVRC-YQEDDSV
|   . . ..||| |||.. | ..  ||  ||  .. .... .| |.|.|. ..   .| . |... .|||..|.   |.  .|.|| .||  ...  . 
mlndd.nerdkkcaryWsdkgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg

PICIHCSAGCGRTGVICAIDYTWMLLKDgiiPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
|. .||.|| |||||...||      |.    ..  .| |.. .| .|| ||||.|||..||.|||| . 
PllvhclaGvGrtgvlltidsvvaeakr...ekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 29-290 5.2e-48 158.3 In-house 15-293 (301) alignment 
Range on Protein: 29-290
Range on HMM: 15-293/301.0
LKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITS--DEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIV
 |.. | .. |  .  ..||  . .| . ||.|.| .||  |. |.  ..      .||||..|.|.   |..||.|||.  || ||||.||.. .  ||
nkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKF-----------------NSETRTIYQFHYKNWPDHDVPSSIDPILELI
| . . |  |.|||.|| .  . . |||||.|    |.   |..|| |.||                  . ..... |..  .||.. |      .|. |
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqvi

WDVRCY-QEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIpenFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF
 ||    |  .  |. .|||.. .|.|| |... .    |   .     || ... .| ..|  |.| |||  .|... . .
ddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegV...VdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 30-288 1.7e-49 163.3 In-house 9-264 (283) alignment 
Range on Protein: 30-288
Range on HMM: 9-264/283.0
KLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSdedsSYINANFIK---GVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIV
||.|.  |  .    ....|   .| .|||...|.|.|  ||||   .     .|||| ||         | ||..|.||  |  |||.|...  .  ||
klfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaiv

MACMEYEMGKKKCERYWAEPGemQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN---SETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPI
|     |  ..|| .|| . |    ..|.| |. . |  .  .||. | .. |    .|  .  . . .| . .  . |. .. .   .   .|    ||
mltklqedlrikCsqyWPkrG..sedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPi

CIHCSAGCGRTGVICAIDYTwmlLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
 .|||.| |||.| .|.  .   .||        ||. .. || ||. .|||..|| ||...|||
vvhCstgiGrtavfiaasas...vkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 31-291 6.9e-30 98.7 In-house 29-291 (310) alignment 
Range on Protein: 31-291
Range on HMM: 29-291/310.0
LKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDeDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACM
| .|  |  |..    |     |...|||| |..  | ||| | .  |     || ||..|  |  ...| .||||  |..||||||..     |.. | 
lvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllck

EYEMGKKKCERYWAEPGEMQlEFGPFSVSCEAEKrKSDYIIRTLKVKFNS------------ETRTIYQFHYKNWPDHDVPSSIDPILeliwDVRCYQED
  | |. ||  ||   |  .  .|   |.  .|    .. |  | | |              .   .   .. ||||  ||      .      |   . 
vgeegrpkcvgywpslgvte.tygcirvtnlses.seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv....pqrllaqv

DSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIipeNFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
   |  .||||| .|..|..|.....  |. |    .  .  .. |.. .|   .||. || ..    . . .
rhgpcvvhcsagkdrlyvvvalklkidkldrgl...kvdaeevktellksraiciqtelqyliidrvriifar
subfamily_PTPN3_pd Subfamily PTPN3 35-292 1.3e-71 235.8 In-house 22-277 (280) alignment 
Range on Protein: 35-292
Range on HMM: 22-277/280.0
STKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSlitsDEDSSYINANFIK----GVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACM
 . |. ..   ...| ||.|..||||.||||||  ||.|.    .... |||||...    .    . ||||||||..|  |||.|.|| .. .|||   
eqlyrkkpglaisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmltt

EYEMGKKKCERYWAEPGEmQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS--ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCS
  | |..|| .|| |... .||.| ||| || |.... |..| | .| ..  | |.| |. | .||||.||.. . .||..  || ... .. |. .|||
lverGrvkChqyWPeted.eleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCs

AGCGRTGVICAIDYTWMLLKdgiIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKR
|| |||||. ... . .|.    . |.. .  ..|.|| || .||||..||..| .|.|.... 
aGigrtGvlilletalalie...aaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 35-291 6.2e-71 233.9 In-house 30-280 (315) alignment 
Range on Protein: 35-291
Range on HMM: 30-280/315.0
STKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEM
       . .|  || | .| .|||| .|..|| |||.| |.  |..| |.|||||.|   .. |||.|||. ... ||||...|. .  |||     | 
yesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlveg

GKKKCERYWAEPgemQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRT
 |.|.|.|| .    .. .|...|.   |. ...| .||| | |... |...|.||  ||| .|| .  |...||  |. .....  .| .||||| |||
ekrkaekywpdk...kviyGkitvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrt

GVICAIDYtwmLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
|  ...|    .|.   . .   |. .|. .| .|  .||. |||...|.|.|| | 
Gtfitlda...vldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfv
subfamily_PTPRN_pd Subfamily PTPRN 36-288 4.6e-61 201.1 In-house 39-290 (297) alignment 
Range on Protein: 36-288
Range on HMM: 39-290/297.0
TKYKADKTYpTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYG-PKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEM
..|.|...  ..||...||.||||.|..|||| |||.|.  .|.|.| |||| .|        |||||||||..|. |||.|.||  | .||. .   | 
cayeaepst.kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleee

GKKKCERYWAEPGEMQleFGPFSVSCEAEKR-KSDYIIRTLKVK--FNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVR-CYQEdDSVPICIHCSAG
| |.|.||| . |.    .. . |   .|.    ||..|.. .|   .|||||. |||.  ||...||.|  ..||.   |  .|.   | || .|||.|
gvkqckrywpdeGsev..yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscpivvhcsdG

CGRTGVICAIDYTWMLLKDGIipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
.||||| ..||     |. |.   .  . . .  .| ||| ||.|..|.|... || |
aGrtGvyilidlvlnrllkGv..keidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPN14_pd Subfamily PTPN14 37-292 2.6e-58 192.4 In-house 34-298 (300) alignment 
Range on Protein: 37-292
Range on HMM: 34-298/300.0
KYKADKTypTTVAEKPKNIKKNRYKDILPYDYSRVELSLiTSDEDSSYINANFIKGVYGPK--AYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEM
| ..| .  ...|. |.| .|||.||.|||. .|||||  | .... ||||  || . | |   ||..|||| .|. |||.|.||  | .|||   | | 
kkredal..lstaklpenaeknrfkdvlPyednrvelsp.tkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeed

GKKKCERYWAEPG--EMQLEFGPFSVSCEAEKRKSDYIIRTLKVKF--NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVR--CYQEDDSV-------
||.|. .|. . .  . ..||| | |. .  .  . .| ..||.|.   .| ||.. . |..||||.||. ... |. . .|.  ... ...|       
gkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskP

PICIHCSAGCGRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKR
|. .||||| |||||.   |     |. .   |.  . . .. .|.|| .||||  ||. ||..... .|.
PvlvhCsaGvGrtGvlilsdlliatlehn...eeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkn
0036941 (Phosphotyrosine protein) phosphatases II 38-295 1.7e-92 305.2 In-house 23-282 (297) alignment 
Range on Protein: 38-295
Range on HMM: 23-282/297.0
YKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELslitSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKK
..  . ....||..|.|..|||||||||||..|| |    .||.|.||||....| . ....|||||||..|. |||||.||. | .||| . ..|.|..
lpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgre

KCERYWAEPGEMQLEFGPFSVSCEAEKR--KSDYIIRTLKVKF--NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPICIHCSAGC
||..|| .  .  |..|.|.| .  ..   ..||..|||.|..  |.|.||...|||..||||.||.|....|..|. || ...   .. |...|||||.
kcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGv

GRTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMD
||.|...|.|. ...|.|... ............|.|||  ||| |||. .| |.|||.|... 
gRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkklt
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 38-293 2e-74 245.3 In-house 25-279 (281) alignment 
Range on Protein: 38-293
Range on HMM: 25-279/281.0
YKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKK
....   ..| .....|..||||..|  || .||...   ..... ||||||..|. |.|.|||||||. ..| .||.|.||..| .|||   | | || 
aaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagkl

KCERYWAEPGEmQLEFGPFSVSCEAEKRKSDYIIRTLKV-KFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDV-RCYQEDDSVPICIHCSAGCGRTG
|| ||| .. . .|..| . |. .||..|. || |..|. . ..|||.. |..|..|||| ||..   .||   .| .. ...  .|..|||||| ||||
kChrYWPddns.elkygdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsaGvGrtG

VICAIDYTWMLLKDGIipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQ
.  |.|     ...    |. .|  ...|.| .|  .|||  ||| || |||. ....
tyialDrlvkaveael..eeldvkavvaelrkernlmvqtvvqyefvykavldaldke
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 40-291 1.4e-72 239.4 In-house 32-284 (305) alignment 
Range on Protein: 40-291
Range on HMM: 32-284/305.0
ADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKC
...  .. | .| .| .|||.|.| ..| .|. |.   |..|| ||||....|  . |.||..|||| .|. ||||.|.|. |  ||| .   | ||.||
yeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkC

ERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKF---NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDD-SVPICIHCSAGCGRTG
..||.|    . |||.|||  . ||  ||||.| ||. .   ..|.||. |..  .|||| || .   .|.|| .|.  |. |  ||. .||||| ||||
rqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtG

VICAIDYTWMLLKDgiiPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
| .|.|     ||     |   || .....|..|. .|||..||  ...|. || .
vfiavdialerlkk...EevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 40-296 1.7e-60 199.8 In-house 34-295 (325) alignment 
Range on Protein: 40-296
Range on HMM: 34-295/325.0
ADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMI--WEYSVliIVMaCMEYEMGKK
.| .   .|| ||.|..|||.|.....| ||| |     | .| ||||....   . . ..|.| ||..|. |.||..  |. ||  .|.   | . ||.
sddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsv..vvv.lneldlgkd

KCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS--ETRTIYQFHYKNWPD---HDVPSSIDPILELIWDVR-CYQE--DDSVPICIHCSA
.|  || .      .||.. |.  . .  |||. | |.||  .  |||.. ||... |.|   .  |... .||.|.  |  . .     | || .||||
rcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsa

GCGRTGVICAIdytWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF-KRQMDV
| |||||  ..   . .|.  |   .  .|  .. .| .|||.|.| .|| |.|.|. | .   . ||
GvGrtGvfisl...ysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdv
subfamily_PTPN1_pd Subfamily PTPN1 40-292 4.5e-59 194.5 In-house 18-273 (290) alignment 
Range on Protein: 40-292
Range on HMM: 18-273/290.0
ADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSlitsDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKC
  . .||..|..|.| ..|||.|. |||.||..|     ..|  ||||....     . || |||||. |   ||.|.||     .||     | .. ||
easdfptreaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

ERYWAEPG---EMQLEFGPFSVSCEAEKRKSDYIIRTLKVKF--NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRC--YQEDDSVPICIHCSAGCG
 .|| .     |..||   ..|   .|.||| |..|.|...     |||.|..|||  |||  ||.|    |.....||      .|  |  |||||| |
aqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiG

RTGVICAIDYTWMLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKR
|.| .| .|   .|...    ..  .   . |.| .|  |.||..| .. | |.||  | 
rsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 40-93 4.3e-09 30.2 In-house 33-86 (440) alignment 
Range on Protein: 40-93
Range on HMM: 33-86/440.0
ADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGV
.  . |. .|  |.|  ||||..|| ||.||| |  . .  || |||| .|.|.
sglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 40-127 1e-08 29.1 In-house 20-107 (332) alignment 
Range on Protein: 40-127
Range on HMM: 20-107/332.0
ADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSliTSDEDSSYINANFIKGVYGPKAYIATQGPLS-TTLLDFWRMIWEYSVLII-VM
.  ||| |  .  .|.  ||   .  .|.|||||.    |    . ||... |     ||| .| |.   |   ||||. |    .| |.
samtypntydkflnnmdmnriphlycfdhsrvela..pqdgkddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvf
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 41-341 6.8e-75 247.1 In-house 30-334 (515) alignment 
Range on Protein: 41-341
Range on HMM: 30-334/515.0
DKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCE
 . || |||..  | ||||||.||||| .|| | .|  . .| |.|| .|...   |||||.|||. ... ||||..... |  |.|     |  | || 
pniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcg

RYWAE-PGEmQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICA
.|| . ||.  ..|| ..|.  . .  .. |.|.|.|  ....||. |||...|||. ||     .| || .|.. ..  . |. |||||| |||||...
kyWPdkpgd.svkfGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvis

IDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK---------RQMDVIRDKHSGTESQAKHCIPEKNHTLQadSYSPNLPK
||      |..   .   || ... .| .|| |||||||| ..|.|||| ..            | ..| ||  . . .  . .. .||.  |  |. | 
idsvvahaktt...rmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlk..slcpdppa

STTKAAKMMNQ
| |....  ..
sqtrsgrtrdn
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 41-292 2e-70 231.8 In-house 7-266 (270) alignment 
Range on Protein: 41-292
Range on HMM: 7-266/270.0
DKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYG-PKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKC
..| .... |  .. | |||.||||   .|| |. ...|. . |||||...|. | .|.|||..||| ||| .|||||||  |  |||.    | |.|||
eetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkC

ERYWAE-PGE-MQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSID------PILELIWDVRCYQED--DSVPICIHCSA
||||.. |.| ..||.|  .|  ..|.... ||.. |... ..|.| .  |.|..|||| ||.. |       .|... .|| ....  .. |. .||||
erYWpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsa

GCGRTGVICAIDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKR
| ||||.. |.|..  ||.     ..  | ..|.|.| .|. |||. ||||..|.||.|  .|
GvgRtGtlialDiavrlLeet...kkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 41-304 3.6e-70 231.3 In-house 31-291 (315) alignment 
Range on Protein: 41-304
Range on HMM: 31-291/315.0
DKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCE
 ..|...|| .. | ||||||.|||.| .|| | .|  . || |||| .||.|   |||||.|||| ... |||||.... |  |||     |  | || 
PdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcr

RYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAI
.|| .      ||| ..|.    .  .| ..| | ..   |.||. ||....|||. |.     .|.|| .|.. .. .  .. .||||| |||||...|
qywPdrkadsvefGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisi

DYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDKHSGT
|     .|..   .   || .....|..|| ||||.|.| ..|.|||| .. .  .|   |   
devvaqikrt...rsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftd
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 41-294 5.7e-55 181.3 In-house 32-240 (392) alignment 
Range on Protein: 41-294
Range on HMM: 32-240/392.0
DKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGkkkce
 . ||.|||.|. |.||||||.||||| .|| | .|    || |.|| .|...   |||||.||| ...| |||||...  |  |.|     |       
pdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.....

rywaepgemqlefgpfsvsceaekrksdyiirtlkvkFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAI
                                        ..||. |||. .|||.|||     .|..| .|..   . . |. |||||| |||||. .|
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisi

DYTWMLLKDGIIpenFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQM
|      |   .     || .. ..| .|| .|||.||| ..| |||| .  . 
dsvvahakktrm...vdvfnfvtnirrkrpymvqtkeqyafiygavledllwrn
subfamily_egg_pd Subfamily egg 43-295 5.1e-27 89.3 In-house 29-275 (307) alignment 
Range on Protein: 43-295
Range on HMM: 29-275/307.0
TYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMgkKKCERY
  . | | .  | .| | | .   |.|||.| |        .| || .||      .| .| ||  |  |||||...  |  |||     |   ..|| |
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyy

WAEPGEMQLEF--GPFSVSCEAEKRKSDYIIRTLKVKFNSETRTiyQFHYKNWP-DHDVPSSIDPILELIWDVRcyqeDDSVPICIHCSAGCGRTGVICA
|    .  | .  | . . .   ..|.| . |  |.|     .   . . . |  | .  | .   |...  .|    . | |. ...  |. ..... |
wpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgdde..erflehwqgdvnnssdvysplrvlrklr....nlskpvvvqdilGvskaatlva

IDYTWMLLKDGIIpENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMD
|. . . |  | |   . |   .  .| .|.  |..  .| .||  || .|.  . 
ieiallsllrGpi.tkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvig
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 43-179 8.2e-06 18.8 In-house 16-116 (169) alignment 
Range on Protein: 43-179
Range on HMM: 16-116/169.0
TYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINAnfikgvygpkayiatqgplsttlldfwRMIWEYSVLIIVMACmeyemGKKKCERY
 |   .||   |  |||    |   . ||.|  .  |  | ||||                           |||||    .||.       .    . .
eynnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlg.....dtddknnf

WAEPGEMQLEfgPFSVSCEAekRKSDYIIRTLKVKFN
| |  . ||   |  .  |         .|| ||. |
wpekedyqlh..pavilgew..ytdslyvrtdkvhan
0040439 (Phosphotyrosine protein) phosphatases II 45-291 9.5e-82 269.6 In-house 2-247 (249) alignment 
Range on Protein: 45-291
Range on HMM: 2-247/249.0
PTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWA
...||..|.|..||||.||||||.||| || . . ..|.||||..|.| | ....|||||||. |. |||||.||. . .|||.. . |.|..||..|| 
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

EpgEMQLEFGPFSVSCEAEKRKSDYIIRTLKVK--FNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQED--DSVPICIHCSAGCGRTGVICAI
.  .  ||.| |.| .  .. |.||..|||...   ..|.||.....| .||||.||.|....|..|  || ..|.  .. |...|||||.||||...|.
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
.. ...|.      ...... ....|.|||  ||..|||. .|.|.|||..
ylmleqleke...lgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0045098 (Phosphotyrosine protein) phosphatases II 46-292 6.1e-78 257.3 In-house 25-274 (278) alignment 
Range on Protein: 46-292
Range on HMM: 25-274/278.0
TTVAEKPKNIKKNRYKDILPYDYSRVElslitsdeDssYINANFIKGVygPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAE
 |.| ...|..|||||||||||.|||         |  ||||..|.|   ||..||||||| .|. |||||.||. . .|||.. ..|.|..||..|| |
itpalylgnldknRykdilpydhsrVk........d..YINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe

pgEMQLEFGPFSVSCEAEKRKSDYIIRTLKVK------FNSETRTIYQFHYKNWPDHDVPSSI--DPILELIWDVRCYQE-------------DDSVPIC
  .  |..|.|.| .. |.. .||..|||.|        . |.|.....||..||||.|||.   ...|||.  .| ...             |.. |. 
..ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvl

IHCSAGCGRTGVICAIDYTWMLLkdgiiPENFSVFSLIREMRTQRPS-LVQTQEQYELVYNAVLELFKR
.|||||.||||...|...   ||     ........ ..|.|.|||   ||..|||. .| ..|||..|
VHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPRA_pd Subfamily PTPRA 46-296 2.5e-68 225.4 In-house 50-304 (330) alignment 
Range on Protein: 46-296
Range on HMM: 50-304/330.0
TTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAE
  .|.| .| .|||. .|||||.||| || .   |.| |||| ||.|    . .||.|||.. |. ||||||||.    |||     |  ..||..|| .
lelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPd

PGemQLEFGPFSVSCEAEKRKSDYIIRTLKVK------FNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICA
 |   . .|   |. | |.   || .| . |.       . ..| . |||.. |||  ||.    .|.|.  |.  ..  . || .||||| ||||  ..
eG..lvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfiv

IDYTWMLLKdgiIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK---RQMDV
.|     .|     .   ||  ....|.||| .|||.||||..|...|| .     ..||
ldavlervk...aerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 46-293 2.5e-61 202.7 In-house 17-260 (284) alignment 
Range on Protein: 46-293
Range on HMM: 17-260/284.0
TTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACmeyemgKKKCERYWae
 | |. ..|  |||. .||..| ..| |  .   | | |||| ||.|   .. ||||||||  || ||||||||| .  ||.        |.|| .||  
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw..

PGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKF---NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCY--QEDDSVPICIHCSAGCGRTGVICAI
| ... . . | |. .. .  ..|..| ...     . . |.| |||.. |||. || .  ... |.  ||    .|..  .| .|||||.|||||  ..
plkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivl

DYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE--LFKRQ
|     .|.    .   |. ..|..| ||..|||   || ..| |.||  || . 
dvlldrmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghs
subfamily_ptpA1_pd Subfamily ptpA1 46-240 3.5e-47 156.1 In-house 39-249 (418) alignment 
Range on Protein: 46-240
Range on HMM: 39-249/418.0
TTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYgPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAE
|.  .| .|  |||| .||| ...||.|  |   | | |||||.| | | || .|.|||||  |. |||||.||  . ||||   | |  . ||.||| |
tsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpe

P-G--------EMQLEFGPFSVSCE--AEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQ------EDDSVPICIHCS
  |        . .  || .||      .  . . | | ... |. ||| | |..|. ||||..|   .|. .|.  .   |       |  ||| .|||
qiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcs

AGCGRTGVICAI
|| |||| .|. 
agvgrtgtfcta
subfamily_eak_pd Subfamily eak 46-201 3.9e-17 56.6 In-house 44-197 (332) alignment 
Range on Protein: 46-201
Range on HMM: 44-197/332.0
TTVAEKPKNIKKNrYKDILPYDYSRVELSLiTSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAE
 ..... .....|   .|.|||.  |.|.  .  .   ||||  ..     . || |  .  . .  ||.|. |     ||.   . |.. .| ..|. .
isetarleavnrn.vvkivpydrylvrlts.sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpd

PGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSS
 .  .|.|| . | .    ... .  | |...   ||  .. ...  | . ..|  
ktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpky
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 46-126 4.7e-11 36.8 In-house 29-114 (347) alignment 
Range on Protein: 46-126
Range on HMM: 29-114/347.0
TTVAEKPKNIKKNRYKDILPYDYSRVELSLI-----TSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIV
 |..|  |...||| ||    | .|| ||        .|.  .||||  ||     | || || ||  |. |||.|.    |  .|
ftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvv
0042113 (Phosphotyrosine protein) phosphatases II 47-291 1.7e-79 262.0 In-house 2-244 (245) alignment 
Range on Protein: 47-291
Range on HMM: 2-244/245.0
TVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEp
.||..|.|..||||.||||||..|| || . .|.||.||||....| . .. .|||||||. |. |||||.||. . .||| . | |.|..||..|| . 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

gEMQLEFGPFSVSCEAEKRKSDYIIRTLKVK--FNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQE-DDSVPICIHCSAGCGRTGVICAIDYT
 .  |..| |.| .  |. ..||..|||.|.   ..|.|.....|| .||||.||.... .|...  || ... |.. |...|||||.||||...|... 
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylm

WMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
...|.      ..|... ..|.| |||  |||..||. .| |.|||.|
leqleke...lgvsleeavkelrsqRpgavqtpsqyrflyeallellk
0037934 (Phosphotyrosine protein) phosphatases II 47-290 8.8e-76 249.9 In-house 3-242 (243) alignment 
Range on Protein: 47-290
Range on HMM: 3-242/243.0
TVAEKPKNIKKNRYKDILPYDYSRVELslitsdEDSSYINANFIKGVygPKaYIATQGPLSTTLLD----FWRMIWEYSVLIIVMACMEYEMGKKKCERY
..| .| |..||||.||||||.||| |      |.|.|||||.|...  |. .|||||||. |. |    ||||.||. . .||| . ..|.|..||..|
siallpenlsknrysdilpydhsrvkl......egsdyinanliyvt..pr.liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WAepGEMqlEFGPFSVSCEAEKRKSDYIIRTLKVKF---NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCY--------QEDDSVPICIHCSAGC
|   ||.  ..|.|.| .  |. ..||..|||...    . .||.....|| .||||.||.|....|... .|| .        ..|.. |...|||||.
wp..gev..tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRTGVICAIDYTWMLLkdgiipeNFSVFSLIREMRTQRPS-LVQTQEQYELVYNAVLELF
||||...|...  .||       ...... ....|.|||   |||..||. .| |.|||.
gRtGtliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 47-291 1.1e-67 222.8 In-house 2-243 (250) alignment 
Range on Protein: 47-291
Range on HMM: 2-243/250.0
TVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKkCERYWaeP
.||.||.| .|||| ||...| ||| |    .|..| |||| |..|  . ||.|||||||..|. |||||..|. .  |||     |..|. ...||  |
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqyw..P

GEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRT--IYQFHYKNWPDHDVPSSIDPILELIWDVRCYQED-DSVPICIHCSAGCGRTGVICAIDYt
 |   ..|   ||   .. ..||..|.||.  ....    . |.|. .|||  ||     .|||. .|.  |.  .. |. ..|||| ||.|  .|||  
vekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida.

wmLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
  .|.   . .   || .|. .|..||  |...|||  ||...|.  .
..vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_PTPRK_pd Subfamily PTPRK 47-288 1.2e-67 222.9 In-house 36-275 (314) alignment 
Range on Protein: 47-288
Range on HMM: 36-275/314.0
TVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEP
 .| | .| .|||..|||.|| ||| |  |  | .| ||||..| .   |.|.|.|||||  |. ||||.....    |||     | |. || .|| | 
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPed

GEMqleFGPFSVSCEAEKRKSDYIIRTLKVKF----NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDY
.|.   .|.. | .   . ......|...|.      .|.|.. ||.. .||||||| |   .|.|.  |   ||..  .| .|||||.||||. .||| 
tev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidi

TW-MLLKDGIIpenfSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
   |. ..|..     ||  ....|.... .|.|.||| ..|...||
vldmieregvv....dvfnavktlrsrkvnmveteeqykfiydvile
subfamily_CG7180_pd Subfamily CG7180 47-289 4.9e-53 174.7 In-house 35-289 (296) alignment 
Range on Protein: 47-289
Range on HMM: 35-289/296.0
TVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKkKCERYWAEP
  . . .|..|||. ...|||| || |. .  .|.| |||| .. .   .|.|| |..|   |. .|||....  .  .|. . . .. | ..  || . 
agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnk

GemQLEFGPFSVSCEAEKRKSDYIIRTLKVKFN------------SETRTIYQFHYKNWPD-HDVPSSIDPILELIWDVRCYQED-----DSVPICIHCS
.  . ..|.. |    ||  ..  |||.|.. .             |||.. .|... |.  . ||.|   ..||.  || ..|      .  |.....|
s..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvss

AGCGRTGVICAIDYTWMLLKdgiIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
 | .|.|| .||| .  |..   . |.. ||  .. .| .|| ||.. |.|  .|. .|| 
dGasRsGvylaidanlelve...keeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 47-291 3e-42 139.7 In-house 34-278 (307) alignment 
Range on Protein: 47-291
Range on HMM: 34-278/307.0
TVAEKPKNIKKNRYKDILPYDYSRVELSliTSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEP
||     | .||||.|.   | .|. .   ..   | || ||..     || .|..|||| .|  .|| |. .  |  ..| |   |..| |||.||   
tveafsantdknryqdvkcqdkgrivvk..fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywple

GEMQLEFG--PFSVSCE---AEKRK--SDYI-IRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCyqedDSVPICIHCSAGCGRTGVIC
   .| ||  | ..| .   |.|     |.| . ||||.. ...||| .. ..||||. ||      ..|.  ||     |  |. .||||| ||.| | 
egqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvvvhcsaGvGrsGtiv

AIDYTWMLLKDGIIPENfsVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
|| .    . .||   .  .  |..|.|.||.  .||. ||  ..  .|| | 
aislvqdkmiaGinckd..mkklveelrsqrhyaiqteaqylylhrvlleyfl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 47-293 4.2e-33 109.5 In-house 28-273 (285) alignment 
Range on Protein: 47-293
Range on HMM: 28-273/285.0
TVAEKPKNIKKNRYKDILPYDYSRVELslitSDEDSSYINANFIKGV-YGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAE
| .    |   ||| |.   . .|| |     . |  || |....       .||.|||||  || |||.||..  .  ..| |  .| | .||  |. |
tytayeanpdlnryadvrcieetrvvl....knhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

PGEMQLEFGPFSVSCEA--EKRKSDYIIRTLKVKFNS--ETRTIYQFHY--KNWPDHDVPSSIDPILELIWDVRCYQEdDSVPICIHCSAGCGRTGVICA
     ..|| . ..     |.  .  |. .| |       .  .|  |     |||.  |    |..||   |.  .     |||.||||| |||  .  
klgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatfvg

IDYTWMLLKDGiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQ
|||. . . .     |  .. ..||||. |   ||.. |. ..|  ..| |  .
idyatirimen...pniemldivremramrfqavqshmqflflyvvlmeyfige
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 47-205 3.3e-30 100.0 In-house 26-186 (297) alignment 
Range on Protein: 47-205
Range on HMM: 26-186/297.0
TVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDssYINANFIKGVYG--PKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWA
..| ..  ..||||.||| .| .|| |    ...|  ||||...       .  || .|||||.|. |||....|  | .||| .   | |..||  || 
ssakrnsslrknryrdilatddtrvkllrviterd..yinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

EPGEMQLEFGPFSVSCEAEKR--KSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPI
.  . .|. | . |   ..        |.  |.. . ||.| .    . .|||| ||| .. .
svvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 47-145 8.2e-15 49.0 In-house 41-155 (349) alignment 
Range on Protein: 47-145
Range on HMM: 41-155/349.0
TVAEKPKNIKKNRYKDILPYDYSRVELSLI----------TSDED----SSYINANFIKG--VYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACM
 ..|  .   ||||||||||..||| |             ||. |      |||||..|   .   | ||||| || .|. ||...|    | ...    
ilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnd

EYEMGKKKCERYWAE
. | . .||..|| |
dkelslekcdiywqe
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 48-146 7.2e-23 75.9 In-house 41-153 (350) alignment 
Range on Protein: 48-146
Range on HMM: 41-153/350.0
VAEKPKNIKKNRYKDILPYDYSRVELS--------LITSDEDSSYINANFIKGV-----YGPKA-YIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYE
..|  .   |||||.||||. |||.|            | . . |||||..|         |.  |||||.||  |. ||...| .  | .|..   . |
lseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdve

MGKKKCERYWAEP
.. .||.||| | 
lnlekcyrYWqeg
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 49-288 7.2e-48 157.8 In-house 2-238 (239) alignment 
Range on Protein: 49-288
Range on HMM: 2-238/239.0
AEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYG-PKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPG
|.|  |  |||| .|. ||.||| |  .. |  | ||||....   | ||||||||| ....  |||||.|.    .|||     |  |||| .|| .  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

EmqlEFGPFSVSCEAEKRKSDYIIRTLKVKF--NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYtwm
    ..  . |.    .  .||||||. .    ..| | .||.|.  |||. ||     .| |   .       . |  |||||| |||| .  ||    
s...kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida...

LLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
.|..    .   .|  .. .| .|| .||| ||| ... ||||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 49-288 8.4e-48 157.6 In-house 3-239 (239) alignment 
Range on Protein: 49-288
Range on HMM: 3-239/239.0
AEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYG-PKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPG
|.|  |  |||| .|. ||.||| |  .. |  | ||||....   | ||||||||| ....  |||||.|.    .|||     |  |||| .|| .  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

EmqlEFGPFSVSCEAEKRKSDYIIRTLKVKF--NSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYtwm
    ..  . |.    .  .||||||. .    ..| | .||.|.  |||. ||     .| |   .       . |  |||||| |||| .  ||    
s...kycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida...

LLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
.|..    .   .|  .. .| .|| .||| ||| ... ||||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 49-133 1.4e-13 45.1 In-house 91-174 (244) alignment 
Range on Protein: 49-133
Range on HMM: 91-174/244.0
AEKPKNIKKNRYKDILPYDYSRVELSLitSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVM-ACMEYE
| .|.|  |||    ||.|..|| ||   .    .|||| |.  .     || || ||. | .|||.|. |  | ..|.   .| |
afnpnnswknregaglpfdfnrvplsk..gsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 52-293 1.9e-68 225.5 In-house 26-271 (274) alignment 
Range on Protein: 52-293
Range on HMM: 26-271/274.0
PKNIKKNRYKDILPYDYSRVELSLI-TSDEDSSYINANFIKGV-YGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEM
... .|||||.||| . ||| |.   ..||||||||||.|||  .  |||.||||||..|. ||||||.. .| .|||     |. ..||..|. .  ..
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

--QLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSV---PICIHCSAGCGRTGVICAIDYTW
  . ..| ...  |  ... || .|.| .|  ...|... . | .||||..| .....|.|. .|.  .|...    |. .||||| ||||.  ||. . 
eiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisiav

MLLKDGIIpenFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQ
  |.. |.     |.... ..| .|  .|||.|||||...|. .  || 
rqlreeiv...vdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 52-288 4.2e-23 76.4 In-house 45-277 (303) alignment 
Range on Protein: 52-288
Range on HMM: 45-277/303.0
PKNIKKNRYKDILPYDYSRVELSlitsdeDSSYINANFIKgVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMqL
 ||..|||. |..  |.|.|.||      ||||| |.... .   |  | || ||| |  |||.|| |  |  ...   . |. |   .  . .  .. |
vknmdknrfvdvicldhskvkls......dssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdf.l

EFGPFSVSCEAEKRK---SDYIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDP-ILELIWDVRCYQE--DDSVPICIHCSAGCGRTGVICAIDYTWM
.|   |.     ||      . .. | |   .    ..  |||.||  ..||   | ..  ||... .     || |      .||||.| .. .. . .
kfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfetahl

LLKDGIipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
 |..      . .   .  .|  |   ||   |. .||  . |
slhseq..asldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 53-288 4.9e-45 148.6 In-house 2-237 (237) alignment 
Range on Protein: 53-288
Range on HMM: 2-237/237.0
KNIKKNRYKDILPYDYSRVELSLITSDedSSYINANFIKGVYG-PKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPgEMQL
.|  |||| .|  ||.||| |    |.  | ||||...||. | || |||.|||| ..  |||.|.|.    .|||     |  ..|| .|| .  .   
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst.dqpa

EFGPFSVSCEAEKRKSDYIIRTLKVKFN---SETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRC--YQEDDSVPICIHCSAGCGRTGVICAIDYTWML
 .| ..||   ..  ||| .|.| .  .    | | |.|...  |||. ||     .| .  ..        .| |  |||||| ||||..  ||     
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

LKDgiiPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
 |.    .   ..  .  .  .|| ..||..|| ......||
ake...kkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 53-300 1.2e-33 111.4 In-house 42-282 (288) alignment 
Range on Protein: 53-300
Range on HMM: 42-282/288.0
KNIKKNRYKDILPYDYSRVELSlitsDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLE
.|  ..||...   |..|| ||    |.   ||.|| .     ..  | .| || .|.  .|.|. |  |  ||| |   | ||.| . |.      .  
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

FGPFsvsCEAEKRKSDYIIRTLKVKFNS-----ETRT-IYQFHYKNWPDHDVPSSIDPILELIWDVrcyqEDDSVPICIHCSAGCGRTGVICAIdytWML
.| .   |   |.| . | ...||         |..  . . |...|.|. || .  . | |.  .    ..   || .|.||| |||| .  |    . 
igrl...ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlili...lia

LKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE-LFKRQMDVIRDK
|.   .... .. ||. ..| .|   .||. ||  |.  ||| |  ..  | |..
leslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvlred
Y_phosphatase Protein-tyrosine phosphatase 54-288 4.8e-82 270.3 Pfam-A 1-235 (235) alignment 
Range on Protein: 54-288
Range on HMM: 1-235/235.0
NIKKNRYKDILPYDYSRVELsliTSDED-SSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLE
| |||||||||||| .||.|   ...|. | |||||..||   .|..|||||||. |. |||||.|.. | .||| . . |.|..||..|| |  | .|.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGPFSVSCE-AEK-RKSDYIIRTLKVKFNSET---RTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLL
.| ..| ..  ||  ...|..|.|..| . |    |...|.||.|||||.||.| ...|.||..|. ..|..| |...|||||.||||...|.|. .. |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KDGIIpenFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
...     ..|.....|.|.|||..||. |||. .|.|.||
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 54-288 4.8e-82 270.3 In-house 1-235 (235) alignment 
Range on Protein: 54-288
Range on HMM: 1-235/235.0
NIKKNRYKDILPYDYSRVELsliTSDED-SSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLE
| |||||||||||| .||.|   ...|. | |||||..||   .|..|||||||. |. |||||.|.. | .||| . . |.|..||..|| |  | .|.
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

FGPFSVSCE-AEK-RKSDYIIRTLKVKFNSET---RTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLL
.| ..| ..  ||  ...|..|.|..| . |    |...|.||.|||||.||.| ...|.||..|. ..|..| |...|||||.||||...|.|. .. |
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

KDGIIpenFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
...     ..|.....|.|.|||..||. |||. .|.|.||
eaeee...vdvlqivkelRkqRpgmvqsleqYiflykaile
0041856 (Phosphotyrosine protein) phosphatases II 54-294 8.7e-52 170.7 In-house 1-175 (182) alignment 
Range on Protein: 54-294
Range on HMM: 1-175/182.0
NIKKNRYKDILPYDYSRvelslitsdeDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACmeyemgkkkCERYWAepgemqlef
|..||||.||||||.||          |..|||||.. | . .. .|||||||  |. ||.||..|. . .||...         .|.||.         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

gpfsvsceaekrksdyiirtlkvkfNSETRTIYQFHYKNWPDHDVPSsIDPILELIWDVRCyqedDSVPICIHCSAGCGRTGVICAIDYTWMLlkdgiip
                         . ..|...|..| .||||.||. .| .|..| .|.     .. |. .|||||.||||...|... . |       
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.......

eNFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQM
 ..|... ....| .||  |.| .|| ... |.|||.....
.gvsleeavklvrsrRpgmvitpnqyfflqlallellllkk
subfamily_CG42327_pd Subfamily CG42327 54-214 8.6e-30 98.5 In-house 28-192 (319) alignment 
Range on Protein: 54-214
Range on HMM: 28-192/319.0
NIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVY-GPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWA--EPGEMQ
  .|.|. ...|   .|| |  |..|. . |..|....|    |  |||.| .|  .  ||||..||    .|| ..  .| | |.| .|.   | .. .
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldnt

LEFGPFSVSCEAEKRKSDYIIRTLKVKF--NSETRTIYQFHYkNWPDHDVPSSIDPILELIWDVRC
  .| . |.    . |  |.| || .|   ..|.| .  . | .|.. .||..  ... .. .|| 
slyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrs
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 57-282 2.5e-30 100.3 In-house 53-274 (301) alignment 
Range on Protein: 57-282
Range on HMM: 53-274/301.0
KNRYKDIlPYDYS-RVElslITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGP
|.||. . | . |  ||   . .|     | ||.|.    |. .|||||||. |  ||| |.  | |  ||| . . |  ..||| | .   . .|. | 
khryptv.PckPstave...vivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

FSVSCEAEKR--KSDYIIRTLKVKFNS---ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRcyqeDDSVPICIHCSAGCGRTGVICAIDYtwmLLKDG
|..  . ..   . . . |||.|.  .   .|||.  . |..|.|..|| |   . .|.  |.    .   || .||||| ||.    . .|   | .. 
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk....ksekPivvhcsaGiGrsvafigtey...larev

IIPENFSVFSLIREMRTQRPSLVQTQEQY-ELV
    .  .   ....| .| . |||..|   . 
eadptieltealkhlrehrwngvqtnsqlywmt
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 57-299 3.3e-27 90.0 In-house 46-285 (312) alignment 
Range on Protein: 57-299
Range on HMM: 46-285/312.0
KNRYKDILPYDYSRVELSlitSDEdSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEP-GEMQLEFG-
 ||| .|  .|  |  |.    ||   || |||.| .  |. ...|||||  |   ||..    .   |.. |   | | .|| .| ..  | ..||   
lnrypniqcwdrgrftla...gde.nfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhr

PFSVSC---EA-EKRKSDYIIRTLKVKFNS--ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRcyqeDDSVPICIHCSAGCGRTGVICAIDYTWMLLK
 .. .|   |   | |     | |||  ..  .   . .. .  |||| .| | |  | |.  |.     |  |.  ||||| |||| .. |.     |.
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavk....kdkkpviahcsagvgrtgtlaliesmiaalr

DGIIPENFSVFSLIREMRTqrpSLVQTQEQYELVYNAVLELFKRQMDVIRD
     .   .| |.|  |.     |..  ||  .  .|||..  .    |.
hprkqnvkdsfvllrkdra...rsvrvfpqyvyalrcvleflyskglykrn
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 64-195 4.6e-10 33.9 In-house 3-123 (130) alignment 
Range on Protein: 64-195
Range on HMM: 3-123/130.0
LPYDYSRVElslitsdeDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLII-VMACMEYEmgkkkcERYWAEPGEmqLEFGPFSVSCEA
|....||..        .  ||||.|.  .   . |. || ||. | .|||.|. |  | .. |.  .| |      . || .     ||.    .    
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee......deywpdseP..lewyeediivtl

-EKRKSDYIiRTLKVKFNSET----RTIYQFHYKNWPD
 .. ....| .. ... .|.     ...  |.  ||| 
tdrdefkni.kasnleiesdlneshqaltmfqisnwps
0044763 (Phosphotyrosine protein) phosphatases II 65-291 2.5e-32 107.3 In-house 1-172 (178) alignment 
Range on Protein: 65-291
Range on HMM: 1-172/178.0
PYDYSRVELSLITSDEDSSYINANFIKgvygPKAYIATQGPlsttlLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEmqlefgpfsvsceaek
|.| .|| || .   | | ||||..|     |  |.....|      |......|. .  ||. . |.|.|. || .|| |  .                
pldrtrvllsnleglersdyinaseil....pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

rksdyiirtlkvkfnsetrtiYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLlkdgiipeNFSVFSLIRE
                     .|... ..|||.||.... .||..  .. .....  |. .||||| ||.|...|... ..|        ..|... |..
.....................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl........glsleeaiel

MRTQRPsLVQTQEQYELVYNAVLELFK
.| .||  |....|.. .|   |.|.|
vrerRp.ivpnpgqlrqLyefelrllk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 69-302 5.3e-23 76.6 In-house 33-271 (290) alignment 
Range on Protein: 69-302
Range on HMM: 33-271/290.0
SRVELSLITSDEDSSYINANFIKGVYGpKAYIATQGPLST-------TLLDFWRMIWEYSVLIIVMACMEYEMGKK----KCERYWAEPGEMQLEFGPFS
.|| |    .   . || ||...   |  . |.|| |.         |. .|| |. .  |  .|| |   |  ..     |..|  |  . .| |. ..
trvvLkgygkrfnddyiHAnrvtcpng.lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkglt

VSCEAEKRKSDYIIRTLKVKFNSE-TRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQeddsVPICIHCSAGCGRTGVICAIDYTWMLLKDgiIPENF
|.|     . | ..|.| |||. |   |.    .|.| .  |. .   .|.||  |....     |. .||  |  |  .. ||.  . .. .    ...
vkCkskekeddvetRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkask....tpvivHcvdGiSrsAalaaiilgyQkiae..tsgsv

SVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDKHS
.. ... ..| ||  ........  |  ... |... .| .  ...
kledvlkalrkqralaitsalelafvdagivllaievldqfaeeet
0046846 (Phosphotyrosine protein) phosphatases II 77-291 7.7e-43 141.6 In-house 7-174 (176) alignment 
Range on Protein: 77-291
Range on HMM: 7-174/176.0
TSDEDSSYINANFIKGVYgpkaYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLefgpfsvsceaekrksdyiirtlkv
. |.|..|||||.| | .    .|||||||  || ||..|..|. . ..|. . |.|.|. || .|| |  ....                         
gldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.........................

kfnsetrtiyQFHYKNWPDHDVPSSiDPILELIWDVRCYQEDDsVPICIHCSAGCGRTGVICAIDytwML-LkdgiiPENFSVFSLIREMRTQRP-SLVQ
          |... .||||.||.. . .|||.  .| .....  |. .|||||.||||...|..   .| |       ..||.  ....| |||   ||
..........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay...llel.....ekglsveealalvreqRplgavq

TQEQYELVYNAVLELFK
|.|||. .| ..|.|.|
tpeQyrflyefellllk
0043147 (Phosphotyrosine protein) phosphatases II 79-283 1.4e-43 144.0 In-house 2-154 (172) alignment 
Range on Protein: 79-283
Range on HMM: 2-154/172.0
DEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACmEYemgkkkcerywaepgemqlefgpfsvsceaekrksdyiirtlKVKF
||.| ||||......| |. .|||||||. || |||||..|. . .||... |                                            .  
degsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnlt.el..........................................lydp

NSETRTIYQFHYKNWPDHDVPsSIDPILELIWDVRC-YQEDDSVPICIHCSAGCGRTGVICAIDYTWmllkdgiipENFSVFSLIREMRTQRPSLVQTQE
  ..|...|..| .||||.|| ... .||..  ..  ...... |...|||||.||||...|... .         ...|..  ....|..||  ||...
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.........lglsleeavalvrekRpgavqnps

QYELVY
|| ..|
qyrfly
0051082 (Phosphotyrosine protein) phosphatases II 81-287 1.1e-32 108.1 In-house 2-150 (151) alignment 
Range on Protein: 81-287
Range on HMM: 2-150/151.0
DSSYINANFIKGVygpkaYIATQGPLSttllDFWRMIWEYSVLIIVMACMEYEMGkkKCERYWAEPGemqlefgpfsvsceaekrksdyiirtlkvkfns
 |.|||.... |      .....|||.    ||.....|. .  ||. . |.|.|  .| .|. | |                                 
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

etRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCyqeDDSVPICIHCSAGCGRTGVICAIDYTWmlLKdgiipenFSVFSLIREMRTQRPSLVQTQEQYE
  ........ .|||...| |.| .||..  ..    ... |. .|||||.||||...|..     |.       .|... ..|.| .|| .||. .|. 
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml..lg.......vsleealeeyrlkrpgvvqpnqqfl

LVYNAVL
... |.|
fqlfall
0051429 (Phosphotyrosine protein) phosphatases II 82-296 1e-49 164.9 In-house 4-231 (272) alignment 
Range on Protein: 82-296
Range on HMM: 4-231/272.0
SSYINANFIKGVYG---PKAYIATQGPLSTTLLDFWRMiWEYSVLIIVMACMEYEMGKKKCERYWA----------EPGEMQLEFGPFSVSCEAEKRKSD
|.||||....| ..   |.......|||  |  ||||. .|. .  ||. . |.|.|. ||.|||.          . .... ..| ..| .  |. ..|
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YIIRTLKVK---FNSETRTIYQFHYKNWPDHDVP-SSIDPILELIWDvrcyqeddSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPE-----NFSVF
||.|.| ..    ..|.|.....|| .|||| || ...  .|||. |        . |. .|||||..|||...|...  . . .  | .     |. ..
yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

SLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDV
  ..|.| |||  |||.|||. .|.|.|||... ..|
eaveelraqrpgavqteeqylflyeallellrsllsv
0036282 (Phosphotyrosine protein) phosphatases II 82-283 7.1e-45 148.1 In-house 2-163 (174) alignment 
Range on Protein: 82-283
Range on HMM: 2-163/174.0
SSYINANFIKGVYGPKAYIATQGPLSttlldFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEpgemqlefgpfsvsceaekrksdyiirtlkvKFNSE
|.||||......| .. .||.||||.     ||.|..|... ..|| . |.|.|. || .|| |                               . ...
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

TRTIYQFHYKNWPDHDVPSSIDpILELIWDVRCYQED-DSVPICIHCSAGCGRTGVICAIDYTWMLLKdgiiPENFSVFSLIREMRTQRPSLVQTQEQYE
.|...|..| .|||| ||..   .||..  |. .... .. |. .|||||.||||...|...  ..|.    .    ...|.||.|.|||  |||..||.
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrelRlqrpgmvqtpsQyr

LVY
 .|
fly
0049260 (Phosphotyrosine protein) phosphatases II 89-284 4.1e-42 138.7 In-house 1-144 (152) alignment 
Range on Protein: 89-284
Range on HMM: 1-144/152.0
FIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWaepgemqlefgpfsvsceaekrksdyiirtlkvkfnsetrtiyQF
||.|.. |...||||||.. || |||||..|. . .||| . ..|.|| |||.|.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

HYKNWPDHDVPSSIDPILELIWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWmllkdgiipENFSVFSLIREMRTQRPSLVQTQEQYELVYN
.. .|||| ||.... .|.|.. ......|.. |. .|||||.||||...|... .          ..|..  .. .|..||  |....|....|.
lhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 95-284 6e-18 59.7 In-house 3-198 (199) alignment 
Range on Protein: 95-284
Range on HMM: 3-198/199.0
GPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS----ETRTIYQFHY
| . ||||| ||  |. |||.|.||     |||   .    .     ||.       ..| .||....   |.|| | .| .  |.     || | .. .
gqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqf

KNWPDHDVPSSIDpILELIWD----VRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGiIPENFSVFSLIREMRTQRPSLVQTQEQYELVYN
  | ..  |     .. ..       . |...   |. .||| | | |||. |.|      ..        .| . . .|  |  .. . ..|...|.
tswkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshees.ktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 96-284 6.8e-18 59.6 In-house 3-197 (198) alignment 
Range on Protein: 96-284
Range on HMM: 3-197/198.0
PKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNS----ETRTIYQFHYK
 . ||||| ||  || |||.|.||     |||   .    .     ||.       ..| .||....   |.|| | .| .  |.     || | .. . 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

NWPDHDVPSSIDpILELIWD----VRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGiIPENFSVFSLIREMRTQRPSLVQTQEQYELVYN
 | ..  |     .. ..       . |...   |. .||| | | |||. |.|      ..        .| . . .|  |  .. . ..|...|.
swkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrshees.ktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 97-188 2.7e-14 47.3 In-house 236-323 (440) alignment 
Range on Protein: 97-188
Range on HMM: 236-323/440.0
KAYIATQGPLSTTLLDFWRMIWEYSVLIIVMAcmeYEMGKKKCERYWAEPgEMQLEFGPFSVSCEAEKRKSDYIIRTLKVKFNSETRTIYQF
.|.|||| || .|.|||||.. .| .  |.|     ..  | |  ||       . ||||.|     .      .|||..|.. |   | ||
nafiatqmpldstvldfwrlvhdyristiiml...nqlndktcsiywpvn.trsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 105-279 8.6e-20 65.4 In-house 99-277 (302) alignment 
Range on Protein: 105-279
Range on HMM: 99-277/302.0
PLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEK-------RKSDYIIRTLKVKFN----SETRTIYQFHYKNW
|   ||  .| .| .|.| |.|  |   | ..|||  |...  . .|.|| ..|     |        | .. . |...| .       .|.  ...  |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHDVPSSIDPILELIWDVRCYQEDdsvpICIHCSAGCGRTGVICAIDYTWMLLKDGIIPenfSVFSLIREMRTQRPSLVQTQEQY
|||  |   .. |...    .|...    . .||||| |||| . || |   | .   .     . |..  .|. |   ||...| 
pdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvt...dllsivlpvrqcryGavqdeqql
subfamily_hpo-7_pd Subfamily hpo-7 106-291 2.5e-15 51.1 In-house 43-228 (263) alignment 
Range on Protein: 106-291
Range on HMM: 43-228/263.0
LSTTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEKRksDYIIRTLKVKFN----SETRTIYQFHYKNWPDHDVPSS
|  |.  |...|       .|| |  .| |..||..|.    . .. .   .|..   .   | ...||..  .     .|.|. .. || |...  |  
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

IDPILELIWDVRcyqedDSVPICIHCSAGCGRTGVICAIDYTWM--LL-KDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
   ||...  .|     .| .. .|||.| ||.     ..  .   ..  |     ..   ||..|.| .|.. ..|  |       ||... 
areilnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 107-294 2.5e-19 64.4 In-house 38-227 (255) alignment 
Range on Protein: 107-294
Range on HMM: 38-227/255.0
STTLLDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAekRKSDYIIRTLKVKFN----SETRTIYQFHYKNWPDHDVPSSI
| |.  |...|       .|| |  .| |..||..|.    . .| .   .|..      .| ..|||..  .     .|.|.  ..|| |...  |   
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPela

DPILELIWDVRcyqedDSVPICIHCSAGCGRTGVICAIDYTWM--LL-KDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELF--KRQM
  ||...  ||     || .. .|||.| ||.     ... .   ..  |     ..   ||..|.| .|.. ..|  |  .    ||.|.  | ..
reilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlvfpkgel
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 111-293 1e-11 38.1 In-house 132-312 (346) alignment 
Range on Protein: 111-293
Range on HMM: 132-312/346.0
LDFWRMIWEYSVLIIVMACMEYEMGKKKCERYWAEPGEMQLEFGPFSVSCEAEK--RKSDYIIRTLKvKFNSETRTIYQFHYKNWPDHDVPSSIDPILEL
 ||| ||..  . .. .   .  . .     .  | |  |     |     |.      .| |  |  . ||..      |.  |   . |    ||. .
edfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlp.egnsdsvicqvhhhapwkhlqqppktlpiikm

IWDVRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPEnfsVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQ
| .    ..  .. .|.    ||||.  .    |.   | .|| |.   .. ...... |||  |..  ||  .|  |..   |.
ihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepn...iceimknikqqrpggvesfaqyasiyaivfdyiark
0048076 (Phosphotyrosine protein) phosphatases II 150-289 2.2e-26 87.7 In-house 10-142 (145) alignment 
Range on Protein: 150-289
Range on HMM: 10-142/145.0
QLEFGPFSVSCEAEKRKSD--YIIRTLKVKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDsVPICIHCSAGCGRTGVICAIDYTWMll
.| .|.. . .. |  |.   . . .|   .. ..|...|..| .||||.||.... .||..  .. .....  |. .|||||.||||...|..  ..  
glylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll..

kdgiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLEL
      ...|... ....|.|||  |....|.. .| ..|||
......lgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 176-284 6.7e-24 79.7 In-house 40-139 (144) alignment 
Range on Protein: 176-284
Range on HMM: 40-139/144.0
VKFNSETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDsVPICIHCSAGCGRTGVICAIDYTWmllkdgiiPENFSVFSLIREMRTQRPSLVQT
   ....|...|... .||||.||.... .||..  .. ..|..  |. .|||||.||||...|..  .         ...|... ....|..||  |..
yepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk........klglsleealalvrsrrpgavpn

QEQYELVYN
..|.. ...
pgqlrfLle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 180-295 1.4e-18 61.7 In-house 212-349 (350) alignment 
Range on Protein: 180-295
Range on HMM: 212-349/350.0
SETRTIYQFHYKNWPDH---DVPSSIDPILE----LIWDV---RCYQEDDSVPICIHCSAGCGRTGVICAIDYTWM---LLK--------DGIIPEN-FS
|.   .||...|||.|      | || ..||    || |      .... | || .|||||.||||.....|.       |.             .    
sdPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDl

VFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMD
.. .. |.| || |.||. .|.  .|.|.| .|. ..|
isiivnelrkqrismvqnldqfifiYeallfyfaLrkd
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 180-293 2.2e-15 50.8 In-house 215-347 (349) alignment 
Range on Protein: 180-293
Range on HMM: 215-347/349.0
SETRTIYQFHYKNWPDHDV---PSSIDPIL----ELIWD---VRCYQEDDSVPICIHCSAGCGRTGVICAIDYTWMLL----KDG--IIPEN---FSVFS
..   ..|. .|||.|  .   | ||   |    .|| |      ...|.. .. .|||||||||||.. .|.   .|    ..   |  ..     .. 
ekPyellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisi

LIREMRTQRPSLVQTQEQYELVYNAVLELFKRQ
 . |.| || |.||   |.  .|.|.|. |. .
ivnelrkqrismvqnlaqfiaiyealLkyfalk
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 181-299 3.1e-25 83.4 In-house 87-204 (440) alignment 
Range on Protein: 181-299
Range on HMM: 87-204/440.0
ETRTIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDD-SVPICIHCSAGCGRTGVICAIDYtwmLLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQY
|.||. |.||. |||. ||    |.|..| ||   ||   . |. .|||||.|||||| |.|    .|..    ..  .||.|  || .|| .||| |||
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavds...ilreakrsdqidifsfinsmrnnrpqmvqtpeqy

ELVYNAVLELFKRQMD-VIRD
 .|..|||| .      .. |
afvheavlegllcgdtliled
PTPc_DSPc_SM00012 184-288 3.4e-32 106.2 In-house 1-105 (105) alignment 
Range on Protein: 184-288
Range on HMM: 1-105/105.0
TIYQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDDS--VPICIHCSAGCGRTGVICAIDYTWMLLKDGIipENFSVFSLIREMRTQRPSLVQTQEQYEL
|....||..|||| ||.. |.||||...|.  ... .   |...|||||.||||...|.|. .. |...   .....| ...|.|.|||..|||.|||  
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqylf

VYNAVLE
.|.|.||
lyralle
subfamily_PTPDC1_pd Subfamily PTPDC1 185-286 2.6e-10 35.0 In-house 83-172 (182) alignment 
Range on Protein: 185-286
Range on HMM: 83-172/182.0
IYqFHYKNWPDHDVPsSIDPILELIWDVRCYQEDDsvPICIHCSAGCGRTGVICAidyTWMLLKDGIIPENfsvfsLIREMRTQRPSLVQTQEQYELVYN
|| ..   |.|..|. |.. ||...  |    ...   . .|| || |||||. |   .... .. . .|.      |. .| .||. .||.|| ||| .
iy.vynfgwkDygva.sleriLdivkvvafalqeg..kvavhChaGlGrtGvlia...cylvyakrltaek.....aiklvrskrpksiqtreqvelvke

AV
  
fa
PTEN_1 186-281 3e-07 25.5 In-house 95-186 (196) alignment 
Range on Protein: 186-281
Range on HMM: 95-186/196.0
YQFHYKNWPDHDVPSSIDPILELIWDVRCYQEDD-SVPICIHCSAGCGRTGVICAIdytwMLLKDGIiPENFSVFSLIREMRTQRPSLVQTQEQYEL
....   ..|| .||    . ..     ....|.    . .|| || ||.|...|      |.. |        ..|.||.|...      ||... 
veylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaa....yLmykgk.ltadeAlelvrekRppgapnspsqerlle
0038934 (Phosphotyrosine protein) phosphatases II 187-291 1.1e-09 33.7 In-house 81-178 (194) alignment 
Range on Protein: 187-291
Range on HMM: 81-178/194.0
QFHYKNWPDHDVPSSIDPILELIWDVRCYQ-EDDSVPICIHCSAGCGRTGVICAIdytWMLLKdgiipENFSVFSLIREMRTQRPSLVQTQEQYELVYNA
...   .||. .. |.. .|. .  | ..  || .  . .|| || ||||...|    ... .      ..|.   |. .|  ||. ...|...| ..  
eylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa...YLiyr.....lgmsaeeAialfrekRpgaipnqdyleallkr

VLELFK
. ||.|
ykelrk
subfamily_PTEN_pd Subfamily PTEN 187-275 8.5e-07 24.1 In-house 81-165 (184) alignment 
Range on Protein: 187-275
Range on HMM: 81-165/184.0
QFHYKNWPDHDvPSSIDPILELIWDVRCYQE-DDSVPICIHCSAGCGRTGVICAIdytwMLLKDGIIPENFSVFSLIREMRTQRPSLVQT
. .  .  ||  | ... . |.. |.. . | |..  . .|| || |||||. .      ||| ...... .. .|  |.||.  . |. 
rvavypfdDhn.ppplelleeivediekwleedkknvvvvHCkaGkGRtGvliva....yllkslllekaeealelfaeaRtknkkgvti
subfamily_DSP23_pd Subfamily DSP23 201-284 4e-06 21.5 In-house 66-140 (148) alignment 
Range on Protein: 201-284
Range on HMM: 66-140/148.0
SIDPILELIWDVRCyQEDDSVPICIHCSAGCGRTGVICAIdytwMLLKDgiipENFSVFSLIREMRTQRPSLVQTQEQYELVYN
... . |..  |    |. .  . .||  | |||| . |      |.|     ....    | |.| .||  |.| || .||..
aleqvvefvrvvee.aeekneavsvhcllgrgrtgtmlac....ylvke....rklaaaeaiaevrrlrpgsvetveqeklvrd
subfamily_CG42327_pd Subfamily CG42327 216-288 9e-11 36.0 In-house 243-313 (319) alignment 
Range on Protein: 216-288
Range on HMM: 243-313/319.0
QEDDSVPICIHCSAGCGRTGVICAIDYTWMLLKDGIipENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
....  |. .||| | ||||.. | | .   |..    .   .  |.  .| .| | |.|.||||..|. . |
tresqGPlvvhcsdGvGrtGlviasdiairsleesk..rsvdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 221-288 6e-15 49.9 In-house 229-293 (297) alignment 
Range on Protein: 221-288
Range on HMM: 229-293/297.0
VPICIHCSAGCGRTGVICAIDYTWMLLKDGIIPEnfsVFSLIREMRTQRPSLVQTQEQYELVYNAVLE
... .||||| ||.||.   |     |. . ||.   | .... .| ||. |||| ||.||.|.|||.
ayllvhcsaGvGrsGvvvlsdvilaklrkkripd...vaailsilreqrarlvqtleqfellydavlk
subfamily_eak_pd Subfamily eak 222-311 2.3e-07 24.6 In-house 239-326 (332) alignment 
Range on Protein: 222-311
Range on HMM: 239-326/332.0
PIcIHCSAGCGRTGVICAIDYTWMlLKDGIIPENFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFKRQMDVIRDKHSGTESQAKHC
|| | .. |  |.||   ||     | |. . . .||  ||  ....|   | .. |. ..|..||. ..|. . .|| .   |. |. .
pi.iqsarGsaraGvfvvidllir.lidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdlkkyleayaesv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 224-291 2.8e-06 21.6 In-house 2-66 (69) alignment 
Range on Protein: 224-291
Range on HMM: 2-66/69.0
CIHCSAGCGRTGVICAIDYTWMLLKDGIIpenFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
 .|||.| |||| . ||      .|   .     .|  .. ||  || .|  . .| ....|. | .|
vvhcssgtgrtgtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 225-291 2.7e-06 21.6 In-house 2-65 (69) alignment 
Range on Protein: 225-291
Range on HMM: 2-65/69.0
IHCSAGCGRTGVICAIDYTWMLLKDGIIpenFSVFSLIREMRTQRPSLVQTQEQYELVYNAVLELFK
.|||.| ||||   ||      .|   .     .|  .. ||  || .|  ...| ....|. | .|
vhcssGtGrtGtfiaimvemariksekl...vdifnnvqymrkcrpmmvmneneymfihdalvealk