Gene PTPN21 in Homo sapiens

Synonym: PTPD1, PTPRL10, PTPN21

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN14
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP077_AA protein Get Run
HsapP077_AA_878-1169 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
FERM_N FERM N-terminal domain 27-105 1.6e-20 63.2 Pfam-A 1-80 (80) alignment 
Range on Protein: 27-105
Range on HMM: 1-80/80.0
IQLLNNEFVEFTLSVESTGQESLEAVAQRLELREVTYFSLWY-YNKQNQRRWVDLEKPLKKQLDKYALEPTVYFGVVFYV
..||... .|.|.. ..||.. ||.|..||.|.|  ||.|..   |.|...|.|..| |..|...   . |... | |||
VrlLDgtvkevtvddsktgavlletVckrlglteteyFgLafkedkknesnwLdhdktlreqgveegkpttlllrvkfyv
FERM_M FERM central domain 109-220 4.1e-25 78.6 Pfam-A 3-124 (126) alignment 
Range on Protein: 109-220
Range on HMM: 3-124/126.0
SQLQQEITRYQYYLQLKKDILEGSIPCTLEQAIQLAGLAVQADFGDFDQYE-S-Q-DFLQKF-A-----LFP-VGWLQDEKVLEEATQKVALLHQKYRGL
.....|......|.|.|.|.||....|| |.|..||.|..|...||....| . . |....  .     |.|   .|. .   .. .|...  |....||
npkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllpvsprllkkekskqleqrileahknvagl

TAPDAEMLYMQEVERMDGYGEE
.. .|.. |.|..... .|| .
slaeaklkylqaaqslpdyGvs
FERM_C FERM C-terminal PH-like domain 226-308 1.7e-19 60.1 Pfam-A 1-86 (90) alignment 
Range on Protein: 226-308
Range on HMM: 1-86/90.0
DSQGSDISIGACLEGIFVKHKNGRH-PVVFRWHDIANMSHNKSFFALEL--ANKEETIQFQTEDMETAKYIWRLCVARHKFYRLNQ
...|.|. .| . .|. . .|| .     |.|..|...|...  | ..|   .|.....|.... ...|....||.. |...| ..
nkkgtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrdekkkdvlkFyssqlrvnklllklcienhdlfrrrr
0050432 (Phosphotyrosine protein) phosphatases II 871-1170 1.7e-90 298.8 In-house 19-301 (308) alignment 
Range on Protein: 871-1170
Range on HMM: 19-301/308.0
GKEVATRATNDERCKILEQRLEQGMVFTEYERILKKRLvDGECSTARLPENAERNRFQDVLPYDDVRVELvptkENNTGYINASHIKVSVSGIEWDYIAT
 . . .. . .. .|.||. |. |....|.|..|..   ..|.|.|.|||| ..||. |.||||  || |    .....|||||.... .|.... .|||
ilvsslklsvldllkllekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIat

QGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGsRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGC
||||.||. |||.|||||.. .| |.| ..| |||| ..|||     .....||.|..|..  .  . | .. |....| .|..|||.|..||.||.||.
qgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplel.gggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgv

PEDLKGFLSYLEEIQSVRrhtnstsdpqsPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
|.... .|..||......           |..| .|||||||||||..|. .... .||..  .|.. .. .||.||.. |||. || |.||.|. .||.
Ppspeilldflelvrksl...........pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl
subfamily_PTPN14_pd Subfamily PTPN14 873-1172 4.3e-163 536.4 In-house 2-300 (300) alignment 
Range on Protein: 873-1172
Range on HMM: 2-300/300.0
EVATRATNDERCKILEQRLEQGMVFTEYERILKKRLvDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSVSGIEWDYIATQG
|.|||||.|.|.||||..||.|.|||||||| |||. |...|||.||||||.|||.|||||.|.||||.|||||.|||||||.|||||.| |..||..||
eeatratkdkrakilekkleegkvfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqg

PLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPE
||..|.|||||||||||...|.|.|.|||.|.||||.|.|.|.|...||..|.||.||.|..||....|||||.|||....|||||||||||||.||.||
PleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPe

DLKGFLSYLEEIQSVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSR
|.|||||||||.|||||.|||...... .||.|||||||||||||.|||...||.|||||..||..||..||.|||.|||||.||.|||.|||..||.||
DvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylknsr
0039614 (Phosphotyrosine protein) phosphatases II 879-1169 3.7e-81 268.1 In-house 17-290 (297) alignment 
Range on Protein: 879-1169
Range on HMM: 17-290/297.0
TNDERCKILEQRLEQGMVFTEYERILKKRLvdgECSTARLPENAERNRFQDVLPYDDVRVELVPTKE--NNTGYINASHIkvSVSGI-EWDYIATQGPLQ
.  .... ||.... .....|.|..|.      ..|.|.|||| ..||..|.||||. || | | ..  ... |||||..  ..  .   ..|||||||.
svldlllllekansktllllefeellslkp...dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv..dgydlltrkfIatqgPlp

NTCQDFWQMVWEQGIAIIAMVTAEEEGGReKSFRYWPRLGSrhntvTYGRFKITTRFRTDSGCYATTGLKMKHllTGQERTVWHLQYTDWPEHGCPEDLK
.|. |||.||||||. .| |.| ..| || | ..|||  |.     |||.|..|..  .  . | .. |....  .|..|||.|.|||.||.||.|..|.
etvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.....tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppsle

GFLSYLEEIQSVRRHTnstsdpqSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
 .|. ||.........       ... | ||||||||||||..|.  .|. .||..  .|.. ....||.||.. |||. || |.|..|...||
llleflelvrealael.......pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 879-1170 1.3e-56 187.0 In-house 6-285 (305) alignment 
Range on Protein: 879-1170
Range on HMM: 6-285/305.0
TNDERCKILEQRLEQGMVF-TEYERILKKrlvDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENN-TGYINASHIKVSVSgiEWDYIATQGPLQN
 .|  ..| |.| ..   . ..|. . ..   .  .   .  .|...||.... ..|| |. | ...... . |||||...   .  .  ||..||||.|
lddlaayikearvysdkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykr..kkkyivaqgPlkn

TCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRlgSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKH-LLTGQERTVWHLQYTDWPEHGCPEDLK
| .|||....|  .  | |.|   |||..|  .|||   |  ... .|.|... . ..    | .  ||.       ..||| ..| ||||.|| |.   
tvadfWrliveekvstivmltklveggkdkCrqYWpe..sktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat

GFLSYLEEIQsvrRHTNstsdpQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
 .|| ....|   .. .     .. . ||||||||||||||| |  .|..  |.. ||.|. .||  ||..|| .|||| ||.|.. .| . ...
sllslikrvq...kdqk.....kdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 883-1170 1.5e-60 200.0 In-house 13-285 (319) alignment 
Range on Protein: 883-1170
Range on HMM: 13-285/319.0
RCKILEQrleQGM--VFTEYERILKKRLVdgECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQ
|.|.|..   .|.  .  |.. . .   .  . ..|  .|| ..||.|..|.||  || | . .. ... |||||.|       .  .||||.||.|| .
rlkalas...tgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqe..rekfiatqaPlentie

DFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRlgsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKHlLTGQE--RTVWHLQYTDWPEHGCPEDLKGF
|||.||||... |. |.|   | .. |  .|||.    .| ..|||. .|   .     |    ||... ....   |.| | |||.||.|. ||.... 
dfWrmvWeeessivvmltklveklkvklkkywpe....enfeeyGrlivtleeeeeledyiirklklnk.kssevetRevkhfqyteWpdhdvPekatsl

LSYLEEIQSVRRHTNstsdpqspNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
|  |..|.  |..|.        . |. |||||||||||  |  ..|.  .....|||.  .  .|| || ..||.  ||.|.| .|......
ldllkrirksrektq........sgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
0036941 (Phosphotyrosine protein) phosphatases II 884-1170 5.6e-85 280.5 In-house 3-279 (297) alignment 
Range on Protein: 884-1170
Range on HMM: 3-279/297.0
CKILEQRLEQGMVFTEYERIlKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELvptKENNTGYINASHIkvSVSGIEWDYIATQGPLQNTCQDFWQ
.|.||. |   .. .|.|..  ..|..|..|.|.|||| |.||. |.||||. || |   ......|||||..  .. ...  .|||||||.||. |||.
lkllekllflalllkefeel.lpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyv..dgydlkrkfIatqgPlpntvedFWr

MVWEQGIAIIAMVTAEEEGGREKSFRYWPRLgsRHNTVTYGRFKITTRFRTD--SGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYL
|||||.. .| |.| ..| |||| ..|||      ...|||.|..|..  .   .. | .. |..... .|..|||.|..||.||.||.||. . .|...
mvweqnvtvIvmltelvelgrekcaqywple..egesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfi

EEIQSVRRHTnstsdpqSPNPPLLVHCSAGVGRTGVVILSEIMIACLE---HNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
|....|....        ...| ||||||||||.|..|. ..|. .||   ... .||. .. .||.||.. |||| || |.|..|...||.
elvrkvlkll.......psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 884-1170 4.3e-19 63.1 In-house 16-287 (302) alignment 
Range on Protein: 884-1170
Range on HMM: 16-287/302.0
CKILEQRLEQGMVFTEYERILKKRLVDGECSTARlpENAERNRFQDVLPYDDVRVELvptKENNTGYINASHIKVSvsGIEWDYIATQGPLQNTC---QD
 | | ..|... | .|...| . .    .|.. .  .| ..|. .||  .|. .| |   ....  |.|||...|    ..   | .| | ...    ..
akklvksldtaevkkefkkidtmkvdlekCkafk..knlkknqsedvpildsnlvkl...eaepdsyvnaskvevP..eltrsiilaQlpkvdsedsvee

FWQMVWEQGIAIIAMVTAEEEGGReKSFRYWPRLGSRHntVTYGRFKITTRFrTDSGCYATTGLKMKHLLTGQERTVWHL--QYTDWPEHGCPEDLKgfl
||.||... |. . ..  |||  .     ..|..   .  ..||.. . .|   ..   ..| . .  |  |   .|       | |...  |.      
FWrmvfqekivsvvilvgeeelkk.tlselfpkksgdy..keygkmfvNnrk.VekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkya...

SYLEEIQSVrrhtnsTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
.  .....|          .. . ....    |.|| |...   . . .|....   |  ..  .|.||   |..|.||...|..|. ..| 
eliktaakv......fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk
0047943 (Phosphotyrosine protein) phosphatases II 885-1168 3.4e-83 274.6 In-house 3-272 (273) alignment 
Range on Protein: 885-1168
Range on HMM: 3-272/273.0
KILEQRLEQGMVFTEYERILKKRLvDGECSTARLPENAERNRFQDVLPYDDVRVELvptKENNTGYINASHIkvSVSGIEWDYIATQGPLQNTCQDFWQM
..||..|  .... |.|..|.    ....|.|.|||| ..||..|.||||. || |   ......|||||..  ..  ..  .|||||||.||. |||.|
lllekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyv..dgynlkrkfiatqgPlpntvedfwrm

VWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRhNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEI
||||.. .| |.| ..| |||| ..|||  |   ...|||.|..|..  .  ..| .. |....| ||..|||.|..||.||.||.|..|. .|...|..
vweqnvrviVmLtelvelgrekcaqYwplegge.lsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

QSVRRHTNSTsdpqspnPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL
........|        .| .|||||||||||..|. .... .||..  .|.. .. .||.||.. |||..|| |.|..|. .|
rkalealpsn.......gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN3_pd Subfamily PTPN3 885-1167 4.7e-81 266.8 In-house 6-274 (280) alignment 
Range on Protein: 885-1167
Range on HMM: 6-274/280.0
KILEQRLEQGMVFTEYERILKKRlVDGECSTARLPENAERNRFQDVLPYDDVRVELvptKENNTGYINASHIKVSVSG--IEWDYIATQGPLQNTCQDFW
  |.. ||.|.|....|.. .|.  . ..|.||.|||...||..|.||||. ||.|   ||..| ||||..... . .  .   ||||||||..|..|||
lllkeglesGavlaqfeqlyrkk.pglaisaarkpenlsknryrdilpydatrvkl...kesetdyinanyvnmeipstglvnryiatqGPlaktatdfW

QMVWEQGIAIIAMVTAEEEGGREKSFRYWPRlgsRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLE
|||||| . .| |.|   | || |  .|||.    .....||.|... . .  .  |..  | .|.  | .||.. .|||..||.|| |.| . ||...|
qmvweqksslivmlttlverGrvkChqyWPe...tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefve

EIQSVRrhtnstsdpQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQF
.....|         .. . |..||||||.|||||.|| |. .| .|..| . .. .. ..|.||.|||||  ||.||   ... 
rvrklr.........sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_PTPN13_pd Subfamily PTPN13 886-1170 9.2e-73 239.9 In-house 3-271 (273) alignment 
Range on Protein: 886-1170
Range on HMM: 3-271/273.0
ILEQRLEQGMVFTEYERILKKRLVDgECSTARLPENAERNRFQDVLPYDDVRVELvptkENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMV
 |...|.|..   |.. . . . .| .|....  || ..||...|||||. ||.|    ....||||||.||| |   |..|||.|||| .|..||||||
alqkkldqqqPaeefkelrelkpld.tcevgkkkenkdknryrnvlPydetrvkl....gdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmv

WEQGIAIIAMVTAEEEGGREKSFRYWPRLgSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQ
|||   .||||| | |.|. |  ||||    ..... ..|....    ..   ..   |..|.. .|. | | ||....||.|| |   . .| .. |..
weqkaeviamvtlekekgkvkchrywPes.knkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevr

SVRRhtNSTsdpqspnpPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
....  ...        |..||||||.||.|..|  ....  .|... .|.  ..  ||.||  .|||  || |||..... |||
rlqt..dag........PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlks
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 888-1169 1.8e-67 222.4 In-house 10-277 (281) alignment 
Range on Protein: 888-1169
Range on HMM: 10-277/281.0
EQRLEQGMVfTEYERILKkRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIKvSVSGiEWDYIATQGPLQNTCQDFWQMVW
.|  ..|.. .||| . .   ||   . .. .|| ..||....  ||  ||.. |..| .|| ||||.... ...| | .|||||||. .....||||||
sqndnaGfi.eeyeklaa.igvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvp.gykg.ekeyiatqgPvPaslvafWqmvw

EQGIAIIAMVTAEEEGGREKSFRYWPrlgSRHNTVTYGRFKITTRFRTDSGCYATTGLKMkHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQS
|| . .|.|||.| |.|. |  ||||     .....|| .....  ....  |..  .|. .  .|..|.| .|.|| ||.|| |.. | .|.. .|...
eqkvsaivmvtreieagklkChrYWP...ddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlk

VRRHTNStsdpqspnPPLLVHCSAGVGRTGVVIL-SEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
.... .          ||..||||||||||. |    .. |. ...| ||.  |.  ||..|...|||. ||.|||..... |.
ltekktk........aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN9_pd Subfamily PTPN9 888-1171 1.1e-64 213.4 In-house 11-293 (297) alignment 
Range on Protein: 888-1171
Range on HMM: 11-293/297.0
EQRLEQGMvFTEYERIlKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKEN-NTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVW
... ..|.   ||. | ... | |.  ...|. | |.||..||| ||. || |  ..|. .. ||||...       .  .|||||||..|..|||.|||
kekgkrGl.skeyaei.rnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykq..kkafiatqGplkktvsdfWrmvW

EQGIAIIAMVTAEEEGGREKSFRYWPRlgSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQS
|| . .| |.|  .| || |  .|||   .....  .| .....     .  | .. |..|.  |...|.| | |.. ||..| |.. . .|  ||....
eqevlvivmttrvvergrlkcgqyWpl..eeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvre

VRR----HTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSS
 .     .  ...  .  .||..||||||.||||  |  .| .. ||. ...|.  .. .||.||   .||  ||.| |  .... ...
kqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalel
subfamily_PTPN6_pd Subfamily PTPN6 890-1171 5.8e-71 234.0 In-house 22-300 (306) alignment 
Range on Protein: 890-1171
Range on HMM: 22-300/306.0
RLEQGMVFTEYERILKKR-LVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQ
.||.  .  |.|.. ..      . . .. |||.|.||.. .||.|. || |   .  .. ||||. || .| | .  |||||| |..| .|||.|||..
slekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqe

GIAIIAMVTAEEEGGREKSFRYWPRLGSRHNtvtYGRFKITTRFRTDSGCYATTGLKMKH-LLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSV
   .| |.| | | |.||  ||||   ....   ||. ..|.   ..   |    |....    ..||.|.......||.||.|.| . .|..||.... 
nsrvivmttkevErgkekCarYWPdeeekee...yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrk

RRHTNSTsdpqsPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEV---LDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSS
.......      . |..||||||.|||| .|. .|..  .|.. .   .|| ..  ..|.||  ||||  || |||... ......
qeeleea.....eagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
0043336 (Phosphotyrosine protein) phosphatases II 892-1168 1.1e-78 259.9 In-house 18-277 (278) alignment 
Range on Protein: 892-1168
Range on HMM: 18-277/278.0
EQGMVFTEYERILKKRLvdGECSTARLPENAERNRFQDVLPYDDVRVELVP-TKENNTGYINASHIkvSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGI
.. ..  |.|..|.  |  ...|.|.|||| ..||. |.||||  || | . .......|||||..  ..  .  ..|||||||..|. |||.||||.|.
lktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv..dgynvprkfiatqgPlpetvedFwrmvwelgv

AIIAMVTAEEEGGREKSFRYWPrlgsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRh
 .| |.| ..| ||.|...|||      ...|||.|..|..  .  . | .. |....| .|..|||.|..|..||.||.||.|. .|..|........ 
ttivmLtelvelgrvkcaqYwp.....ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale.

tnstsdpqSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL
        ..| |.||||||||||||..|. .... .||..  .|.. ....||.||.. |||. || |.|..|...|
........dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_PTPN23_pd Subfamily PTPN23 892-1166 7.2e-63 207.1 In-house 16-278 (288) alignment 
Range on Protein: 892-1166
Range on HMM: 16-278/288.0
EQGMVFTEYERILKKRLVDGECSTARLpeNAERNRFQDVLPYDDVRVELVptkENNTGYINASHIKvSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIA
. . .| | |.  .|   .  .. |.|  ..|.||..|.||||  || |    ...  |||||..| ..|    |.||||.|||.| .|||.||.||   
aldkkfkeleqkqdkearkrsiaiakl..yseknrsrdilPyDhnRvklr...gskDDYinAsfvk.dlspgcPdfiatqaPlqstlnDFWlmvyeqkss

IIAMVTAEEEGGREKSFRYWPRlgSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHT
.| |.. .|| |..|  ||||   .. .||..| ...| .  .... .    ||...| . . ..| |||.| |||.| |.  . .| .|.|..|  ...
viVmllskeelgkpkvdrYwPe..dkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeav

NSTS-DpqspnpPLLVHCSAGVGRTGVVILS-EIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ
.  |        ||.||||||||||||. |   ....  ..| .|||..|.  ||.||   ||.  |. |.| . ..
qrkskt......PlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 893-1166 4.3e-53 175.7 In-house 33-289 (319) alignment 
Range on Protein: 893-1166
Range on HMM: 33-289/319.0
QGMVFTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK-ENNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIA
.  .  |. |. |.     . . | |..| ..||. ..|..|  .| | ..  |. . |||||...   .  .  |||.||||.|| .|||.|.||. ..
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqr..kdkyiaaqGPldntladfWrmiweyncs

IIAMVTaeeeggREKSFRYWPRlgsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKH-LLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIqsvRrH
 | ..|      ..|  .|||     .  ....|||.     ...  |.   ... .     . | .    .  ||..| |.    ..  .. .   | |
tivllt......kdkcsqywpl....kivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkv...r.h

TNStsDPQSPNpPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ
 .|    . .. ...|||||||||||| |  ....  ..... .|. ...  |||||  ||| | || |.|  |..
lts..kenhra.nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
0051299 (Phosphotyrosine protein) phosphatases II 894-1169 1.2e-86 286.1 In-house 23-287 (288) alignment 
Range on Protein: 894-1169
Range on HMM: 23-287/288.0
GMVFTEYERILKKRLVdGECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIkvSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAI
 ... |.|..|..    ...|.|.|||| |.||..|.||||. || | .... ....|||||.|  ..  ..  .|||||||.||. |||.|||||.. .
tglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi..dgynlkrkfIatqgPlpntvedFWrmvweqnvrv

IAMVTAEEEGGREKSFRYWPRlgsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKHL----LTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVR
| |.| ..| ||||...|||     ....|||....|..  .  . | .. |....|     .|..|||.|..||.||.||.|.... .|..|.......
IvmltklvelgrekcaqYwpl....ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkal

RhtnstsdpqSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
.         |...| .|||||||||||..|. .... .||.....|..... .||.||...|||..|| |||..|. .||
a.........sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleylk
0040438 (Phosphotyrosine protein) phosphatases II 894-1170 2.2e-82 272.2 In-house 18-278 (317) alignment 
Range on Protein: 894-1170
Range on HMM: 18-278/317.0
GMVFTEYERILKKRLVdgECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIkvSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAI
...  |.|..|.  |   ..|.|.|||| ..||. |.||||. || | |... ....|||||..  ..  .   .|||||||.||. |||.||||||. .
talleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv..dgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

IAMVTAEEEGGREKSFRYWPRlgsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRrhtn
| |.| .|| ||||...|||      .|.|||.|..|..  .  . .  . |....| ....|||.|..||.||.||.|.... .|. ||......    
ivmLteleelgrekcaqYwpl....getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal....

stSdpqSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
  .   .|. |.||||||||||||..|. ..|. .||... .|.. ....||.||.. |||. || |.|..|...|| 
..e...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkr
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 894-1171 4.9e-66 218.0 In-house 20-283 (318) alignment 
Range on Protein: 894-1171
Range on HMM: 20-283/318.0
GMVFTEYERILKKRLVDGECSTaRLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAI
 ....||||. ...    .  .   | |. .||....|.||. ||.| .... ... ||||..|    .  .  |||.|.|| .|..|||.|||||. |.
lllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrr..kkayiaaqaPlpetieDfWrmvWeqnsav

IAMVTAEEEGGREKSFRYWPRLGSRhntvTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRhtn
| |.| ||| |..|  ||||  |||    .||. ... . ..... |    .|...  . ..|.|   .||.||..| ||.  ..|. . ..... .   
ivmltqeeergkakvhryWPskgsr....sygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqq...

stsdpQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSS
     .| . |..|||||||||||| |  .|..  .......|.  .  .||.|| ..|||  ||.|.| ||...|.| 
.....ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg
subfamily_PTPRD_pd Subfamily PTPRD 895-1170 1.7e-76 253.1 In-house 24-283 (564) alignment 
Range on Protein: 895-1170
Range on HMM: 24-283/564.0
MVFTEYERILKKrlVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIKVSVsgIEWDYIATQGPLQNTCQDFWQMVWEQGIAII
 ...||..| ..     ....|. |.| ..||......||  || | ...  ... |||||.|.      .  ||||||||..|..|||.||||| ...|
kfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqnssti

AMVTAEEEGGREKSFRYWPRLgsrHnTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRhtns
 |.|  || |..|  .|||     . | |||....|    ..   |  . .|.|.  . . |.| . ..|.||.|| ||  ...|. .........    
VmltkleEkgkvkchkYWPek...g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne....

tsdpqSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
     . . |..|||||||||||. |  ..|.  .......||  .. .||.|| ..||| .|| |..... ..|..
.....pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
0045450 (Phosphotyrosine protein) phosphatases II 896-1169 2.9e-80 265.6 In-house 29-305 (307) alignment 
Range on Protein: 896-1169
Range on HMM: 29-305/307.0
VFTEYERILKKRLV-DGECSTARLPENAERNRFQDVLPYDDVRVELVPTKE--NNTGYINASHIKV------SVSGIEWDYIATQGPLQNTCQDFWQMVW
.. |.|..|.      ||.|.|.|||| ..||..|.||||. || | ....  ....|||||...|      ..  .   .|||||||..|. |||.|.|
llkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlw

EQGIAIIAMVTAEEEGGREKSFRYWPRLgsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKHL-LTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQ
|||. .| |.| ..| |||| ..|||       ..|||.|..|..  .  . |  . |....|  ||..|||.|..||.||.||.|.... .|. .||..
eqgvtvivmltelvelgrekcaqywPde...geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevr

SVRRHtnstsdpQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEV---LDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
.....        ... | ||||||||||||..|.  .|. .||....   .|.. ....||.||.  ||.. || |.|..|...|.
kalee.......lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
0045098 (Phosphotyrosine protein) phosphatases II 896-1169 3.1e-75 248.4 In-house 9-273 (278) alignment 
Range on Protein: 896-1169
Range on HMM: 9-273/278.0
VFTEYERILKKRLVdGECSTARLPENAERNRFQDVLPYDDVRVElvptkenntGYINASHIKVSvsgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAM
...|.|..|    . .|...| ...|...||. |.||||  ||          .|||||.|..        .|||||||..|..|||.|.||.|| .| |
lllefefllllgip.seitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgitvivm

VTAEEEGGREKSFRYWPRlgsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKHL----LTGQERTVWHLQYTDWPEHGCPEDL--KGFLSYLEEIQSVRR
.| ..|.|||| ..|||     ....|||.|..|.   .  ..| .. |.. .|     ....|.|.||.|. ||.||.|..   | ||..||.|.....
ltelvelgrekcaqywpe....ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealk

HTNSTSDP----QSPNPPLLVHCSAGVGRTGVVILSEIMIACLehNEVLDIPRVLDMLRQQRMM-LVQTLCQYTFVYRVLIQFLK
. .|        .... | ||||||||||||....  .|. .|  ....|.. ....||.||..  ||.| || |.|..|...|.
llaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPRB_pd Subfamily PTPRB 896-1171 5.8e-67 220.8 In-house 26-288 (293) alignment 
Range on Protein: 896-1171
Range on HMM: 26-288/293.0
VFT-EYERiLKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAII
 |. |||. ||.   | ....|.|..|...||....||||  ||.| ..|. ... ||||..|.   |  . ..||||||| .| .|||.||||.   ||
rfseeyee.lkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyns..prefiatqGPlpetvddfWrmvwekkssii

AMVTAEEEGGREKSFRYWPRlgsRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHllTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNS
 |.|.  |.|..|  .|||.    ...|.||  |.|    ..   ...  ||...  . .||.| ....| ||.|| ||. | .|......... ..|.|
vmltqlvekgkvkCeeYWPa...deepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektas

TSdpqspnpPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSS
..       |..|||||||||||. |  . ..  .|.....||  ..  ||..|..||||  || |........|...
kr.......PivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 896-1170 2.9e-62 205.6 In-house 29-292 (298) alignment 
Range on Protein: 896-1170
Range on HMM: 29-292/298.0
VFTEYERILKK--RLVDGECSTARLPENAERNRFQDVLPYDDVRVELVP-TKENNTGYINASHIKvSVSGIEwDYIATQGPLQNTCQDFWQMVWEQGIAI
  .|..|. .   .. . | . || ||| ..||..|....|  || |    ..... |||||... . .| .  .||||.||..| .|||.||.|. |. 
yalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh.aykgrn.afiatqaPltetvedFWrmvteedigt

IAMVTAEEEGGREKSFRYWPRlgsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQsvrrhtn
| |.|  || .. |  .|||     ... |||..... . . . . .... ||...  . .||.| .|..| ||..| ||  .  | .|....       
iVmltnleeldktkyhkywPd....egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvr.......

StSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
  |  |. | |..|.|||||||.|  |  . ..  .....|.|. .|. .||..|. .|||  ||.|.| . ...|.|
a.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_Ptp69D_pd Subfamily Ptp69D 896-1169 3.7e-60 198.6 In-house 24-287 (307) alignment 
Range on Protein: 896-1169
Range on HMM: 24-287/307.0
VFTEYERILKKrLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK-ENNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIA
.  |||.. ..  .| .....   ||| .||..|. ..|. || | ... .... |||||.||      . ..|| |.|...| .|||.|..|| . .| 
lakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyke..kkkfiaaqdPveatigDfWRmiaeqevtliv

MVTAEEEGGREKSFRYWPRLgsrhNTVTYGRFKITTRFRTDSGCYATTGLKMKHLL-----TGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRR
|.. ..|  |.|  .|||      ..| ||   ...      . |.   |.. .         ..| |   .|| |..   ||  .| | ..|..... .
mlsnlteknrkkcakYWpie....devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyk

HTnstsdpqspNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
.          . |..|||||||||.|...  ....  |. .. .||  .   ||.|| .||| | ||.|.|| |... .
ln.........rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
DSPc_SM00195 897-1168 1.8e-77 255.6 In-house 3-262 (263) alignment 
Range on Protein: 897-1168
Range on HMM: 3-262/263.0
FTEYERILKKRLVDgECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIKVSvsGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAM
 .|.|......  . |...|. ..| ..||....||||. ||.| .... ... ||||..||..    . .||||||||..|..|||.||||... ||.|
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivm

VTAEEEGGREKSFRYWPRLGsrHNTVTYGRFKITTRFRTDSG-CYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTnst
.| ||| |.||  ||||.    ... |.|.......  .     . .. |....  . ..|.| ..||..||.||.|.. | .|..|..... ....   
lteeeengkekcdrywpees..ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...

sdpqspNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL
      ..|..|||||||||||.... .|..  ||... .||  .. .||.||...|||| ||.|.|.......
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 897-1168 1.8e-77 255.6 In-house 3-262 (263) alignment 
Range on Protein: 897-1168
Range on HMM: 3-262/263.0
FTEYERILKKRLVDgECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIKVSvsGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAM
 .|.|......  . |...|. ..| ..||....||||. ||.| .... ... ||||..||..    . .||||||||..|..|||.||||... ||.|
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga..nkkkkyIatQgPlpstvedFWrmvweekvkiivm

VTAEEEGGREKSFRYWPRLGsrHNTVTYGRFKITTRFRTDSG-CYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTnst
.| ||| |.||  ||||.    ... |.|.......  .     . .. |....  . ..|.| ..||..||.||.|.. | .|..|..... ....   
lteeeengkekcdrywpees..ggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...

sdpqspNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL
      ..|..|||||||||||.... .|..  ||... .||  .. .||.||...|||| ||.|.|.......
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRA_pd Subfamily PTPRA 897-1167 1.1e-56 187.2 In-house 34-294 (330) alignment 
Range on Protein: 897-1167
Range on HMM: 34-294/330.0
FTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK-ENNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAM
| |    |    ... . .|   || |.||. ..||||  || | . . .... |||||.|.         .||.|||...| .|||.|.|||  | | |
freefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyke..kdkfiaaqGPkeetvedfwrmiweqksativm

VTAEEEGGREKSFRYWPRLGSrhntVTYGRFKITTRFRTDSGCYATTGLKMKHLL----TGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQsvrrht
.|  .|  .||  .|||  |.    ||||  ... .  | .  |.   . ...|       ..| |  . .| ||. | | . .| |..|....      
ltelkerkeekcaqywPdeGl....vtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvk......

nsTSDPQSPNpPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQF
  . ..|| . |. |||||||||||  |  . ... .. ....|. ...  ||.||  .|||. ||.|.|.|| ..
..klnqqsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPRN_pd Subfamily PTPRN 897-1166 1e-45 150.7 In-house 32-290 (297) alignment 
Range on Protein: 897-1166
Range on HMM: 32-290/297.0
FTEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVP-TKENNTGYINASHIKvSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAM
  |.| . . .  .  ...|. ..|...|| ..|||||. ||.|   ...... ||||| |       .  |||||||| .|  ||||||||||...| .
ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasail.dhdprapayiatqgplastvadfwqmvweqGvvvivn

VTAEEEGGREKSFRYWPRLGSRHNTVtYGRFKITTRFRTDsgCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYleeiqsvRRHTNSTS
.|  || | ..  ||||  ||    . |    ..    .|   |    . .| | | . |||  . .  |||.|.|   | .| .       ||  | . 
ltrleeegvkqckrywpdeGsevyhi.yevhlvsehiwcd..dylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllef.......rrkvnksy

DPQSpnPPLLVHCSAGVGRTGVVILSEIMIACLEH-NEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ
  .|   |..||||.|.||||| || ..... | .    .||   |. ||.||  ||.|  |. |.. ....
rGrs..cpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
0046845 (Phosphotyrosine protein) phosphatases II 898-1170 2.9e-84 278.1 In-house 4-276 (284) alignment 
Range on Protein: 898-1170
Range on HMM: 4-276/284.0
TEYERILKKRLVDG-ECSTARLPENAERNRFQDVLPYDDVRVELVPTKE--NNTGYINASHIKVSV---SGIEWDYIATQGPLQNTCQDFWQMVWEQGIA
 |.|..|.       ..|.|.|||| ..||..|.||||. || | ....  ....|||||....     . |.  .|||||||.||. |||.|||||.. 
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

IIAMVTAEEEGGREKSFRYWPRLgsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLL-TGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRH
.| |.| ..| |||| ..|||     ....|||.|..|.. ..  ..| .. |....|  ||..|||.|..||.||.||.|.... .|..|.........
vIVmltelvengrekcaqYwple...gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

tnstsdpQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNE---VLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
        ....| .|||||||||||..|. .... .||...   ..|.. .. .||.||.. |||| || |||..|. .||.
.......lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylkl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 898-1168 5.2e-64 211.1 In-house 25-279 (288) alignment 
Range on Protein: 898-1168
Range on HMM: 25-279/288.0
TEYERIlKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVP-TKENNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMV
 ||. .  .   . . ...||..||..||....||||  ||.|    .|... |||||.|... .  .  ||||||||..| .|||..|.|. .  |.|.
eeynsL.aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekk..kkkyiatqgPladtvndfWelvyenktstivml

TAEEEGGREKSFRYWPrlgSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKhlLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTnstsd
|.  |||..|  .|||   . .. . || ...| .   . . . .  | ..   ...|... ..||. ||.|| ||. . .| .|. ..           
telveggktkCeeYWP...dadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad.....

pqspNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL
      |..|||||||||||. |  . .|  .|.....|.  ..  ||.||..||||| || |.|.||..  
....tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPRG_pd Subfamily PTPRG 898-1170 8.7e-59 194.2 In-house 23-289 (563) alignment 
Range on Protein: 898-1170
Range on HMM: 23-289/563.0
TEYERILKKRLVD-GECSTARLPENAERNRFQDVLPYDDVRVELVPTKE--NNTGYINASHIKVSVSGieWDYIATQGPLQNTCQDFWQMVWEQGIAIIA
 |.| . ..   .  ...... ||| ..||  ....||  ||.| |. .  ..  ||||..|.    .   ..|||||||..|..|||.|.|||  ||| 
eefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqks..kafiatqgplkdtfddFWrmiWeqnvaiiv

MVTAEEEGGREKSFRYWPRlgsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLL--TGQ----ERTVWHLQYTDWPEHGCPEDLkgflsyLEEIQSVR
|.|  .| ||.| ..|||.     ...||| ...|   .    .|..  |..|.|    ..    |..| . .||.||.|| ||        | ... |.
mitnlvergrrkcdvYWPk....desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehs......lpvLifvk

RHtnSTSDPQSpNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
..  |.. ..    |..|||||||||||. |  . ..  ...... .. ..| ..| || .||||  ||.|.. .|.. ..|
ks..saankae.aGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 898-1168 1.3e-56 186.7 In-house 11-295 (297) alignment 
Range on Protein: 898-1168
Range on HMM: 11-295/297.0
TEYERILKKRLvDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKeNNTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVT
.|.. .|...   .. |.|. .    .||..|.| .|| || |  .   .. |||| ..       .  || .||||..| .|||..|.||.. .|.||.
aekdllldear.gesfssakrnsslrknryrdilatddtrvkllrvi.terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmva

AEEEGGREKSFRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLltGQERTVWHLQYTDWPEHGCP---EDLKGF--------------LSY
  .|.||.| . |||.      . .    .  ...  .      | |.. .    ..| | | |.  ||.|| |   |||. |              |. 
klqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlal

LEEIQ-SVRRHTNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL
.| .   |    .|    .  | .|||||||||||.|||.||....| | .. . |.  .| .||.|| .||||| |....| . .. |
vemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 898-1167 1.4e-34 114.3 In-house 10-258 (267) alignment 
Range on Protein: 898-1167
Range on HMM: 10-258/267.0
TEYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVpTKENNtgYINASHIKVSVSGieWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVT
 |.| | |       .|.    .|.||||..|.||||| || |  |||..  |||||...    .    .|.||.||.||  ||.... .|....| ..|
kefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr.tkeee..yinasyvegyktk..nafivtqdplkntitdfltvihdqkvpvivllt

AEEEGgrEKSFRYWPRLGSRHntvTYGRFKITTRFRTDSGCYATTGLKMKHLLTgQERTVWHLQYTDWPEHgcpEDLKGFLSYLEEIQSVRRHTNStsdp
   ..  .    . |..|  .    |  . .   .  .   |    |..|       . |    |  |       . | .|  |  | .  .  |     
kvftd..nirlfwPPkmgqak...kyqdltvehslekeendyqiitlelkfkne.sahnvtlyyykkwnin...tnnkpylkplfgilaknqleng....

qspNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQF
   |.||.|.||.||||.|  .  . ..  . ...|.||   |  .|.||. ||.|. .| .....| ..
...nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 899-1166 5.4e-52 172.0 In-house 3-253 (284) alignment 
Range on Protein: 899-1166
Range on HMM: 3-253/284.0
EYERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK-ENNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVT
|. |. |.     . . | |..| ..||. ..|..|  .| | ..  |. . |||||.|.   .  .  ||||||||.|| .|||.|.||. .. | ..|
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqr..kdkyiatqGPldntladfWrmiweyncstivllt

aeeeggREKSFRYWPRlgsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKH-LLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIqsvRrHTNStsD
      ..|  .|||     .  ....|||.     ..|  |.   ... .     . |..    .  ||..| |.    ..  .. .   | | .|   
......kdkcsqywpl....kivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkv...r.hlts..k

PQSPNpPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ
 . .. ...|||||||||||| |  ....  ..... .|. ...  |||||  ||| |.|| |.|  |..
enhra.nivvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_ptpA1_pd Subfamily ptpA1 900-1131 1.3e-32 108.1 In-house 26-259 (418) alignment 
Range on Protein: 900-1131
Range on HMM: 26-259/418.0
YERILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKEN-NTGYINASHIKVSVsgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTA
  |.|.. .   | |      |. .||. ..|| .  ||.|   ...  . |||| .|  .      ..|.||||| ||  |||.||||.   || |.. 
efrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay...pkqfictqgplpntiadfwrmvwenrcriivmlsr

EEEGGREKSFRYWPRLGSRHNTVTYG-------RFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHT
| |  | |  ||||      .   ||        . .      .         ...  . |. | . . ||  ||.|  |.  . |   |  |   . . 
esencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqi

NSTSDpqsPNPPLLVHCSAGVGRTGVVILSEIMIACLEHN
  .||    | |..||||||||||| .  . ||.  |.| 
ipssd...rnvpiivhcsagvgrtgtfctavimmkkldhy
subfamily_CG7180_pd Subfamily CG7180 902-1167 4.8e-41 135.3 In-house 23-289 (296) alignment 
Range on Protein: 902-1167
Range on HMM: 23-289/296.0
RILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTK-ENNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEE
  | .||  |.| ..   || |.||  .|.|||  || |   . |... ||||...   .   . .|| |..| ..| ..||..|....|  . ..| . 
lkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflk..kkeyivteapkketvdefWrlvydeeisavvvLtktf

EGGReKSFRYWPRLGsrhnTVTYGRFKITTRFRTDSGCYATTGLKM----------KHLLTGQERTVWHLQYTDWPE-HGCPEDLKGFLSYLEEIQSVRR
.  . .   |||  .       || . . .          .  .|.          ..  . ..|.| ..|.| |.  . .|   ....  .. ....|.
dfak.mypsywpnks....keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwre

HTnstsDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQF
..    | .  . |..|..| |..|.|| .  .. .  .|..| .|. . . .||..|  ||..  .| ..| || ..
kv....dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 903-1170 4.1e-51 168.6 In-house 28-285 (290) alignment 
Range on Protein: 903-1170
Range on HMM: 28-285/290.0
ILKKRLVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKENN---TGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAE
 |..   . .  ..  ..| ..|||.....||| |. | |  ...     ||||..||      . .|||||||..||  |||...|.. ..|| |.| .
mldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyke..kkqyiatqgpvsntlvdFWkliwqekvtiivmltni

EEGGREKSFRYWPRLgsrhNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLT-GQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNstsdpq
 | |..|   |||      .| .|| |.|.    .    | .. |..|.  . |....| ..| | |...|  .. .. |. .||..  .|..       
ieegkvkCqqYWpds....dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg......

spNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
  | ...||||..|||..| .  .. |   . . | |.  ||  .|.|.. .|||  || ........ |.|
..ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 903-1173 6.3e-31 102.2 In-house 29-292 (305) alignment 
Range on Protein: 903-1173
Range on HMM: 29-292/305.0
ILKKRLVDGECSTA-RLPENAERNRFQDVLPYDDVRVELVPTKEnnTGYINASHikVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEE
   ||. | |   | .  ..|..||..||   |. || | ..      || | .  ||       .| || ||..|| ||| | ... .  | |.    |
vamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwp..heyihany..vstptnpkrfictqaplektcadfwymclqdkveaifmlcnlle

GGREKSFRYWPRLGSRHNTVTYGRFKITTRFR--------TDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIqsvRRHtns
 | .| . |..       .   .  ||. .|         .|.    |    .     .. | | |  . |||. | |      |  ||.    |     
kgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka...rps...

tsdpqspNPPLLVHCSAGVGRTGVVILSEIMI-ACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSRL
         |. ||||||.|||| |.. | ..   |. . . |  ..|  .|.||   .||  || ||..|......  .|
.......kgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkkl
0049772 (Phosphotyrosine protein) phosphatases II 905-1169 4.5e-41 136.9 In-house 30-281 (314) alignment 
Range on Protein: 905-1169
Range on HMM: 30-281/314.0
KKRLVDGECSTARLPENAERNRFQDVLPYDdVRVELVPTKENNTGYINASHIKVSvsgieWDYIATQGPLQNTCQDF----------WQMV--WEQGIAI
   |... . .|.|..| ..||..|.||.|  || |     ....|||||...        ..|||||||..|. ||          |.||  ... . .
lsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrd

IAM---------------------VTAEEEGGREKSFRYWPRLGsrhntvtygrfkittR-------FrtdsgcyattglkmkhlltgqERTVWHLQYTD
| |                      .   ..| | ...... |                .       |                     ||.. .. ...
ivmsrdevladelsrLdaAlgKtpllildgngneptaadlellk...............eelydpelf.....................erlgikylrip

WPEHGCPeDLKGFLSYLEEIQSVrrHtnstsdpqsPNPPLLVHCSAGVGRTGV-VILSEIMIAClehnEVlDIPRVLDMLRQQRM-----MLVQTLCQYT
.| ...| .|. |.. || |...  .         .. |.||||.||.||||. |..  .|...     | ..  .|...|..|.      ....|.|| 
vpDgsap.lledfdeflefieea..d.........kggpvlvHCkaGkgRtgtfvvaaylmkll....gv.sleealedvrlkRpinpnpgfieqleqye

FVYRVLIQFLK
|....| ..||
filealleylk
subfamily_PTPRK_pd Subfamily PTPRK 906-1166 2.5e-51 169.4 In-house 34-275 (314) alignment 
Range on Protein: 906-1166
Range on HMM: 34-275/314.0
KrlvdgeCSTARLPENAERNRFQDVLPYDDVRVELVPTKEN-NTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGR
         .|.  || |.||..|.|.||  || |...... .. ||||. |          .|.||||||.| .|||..|.... | | |.|   | ||
g......wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykr..paafivtqgPlqetvkdfWrlvydencasivmltelvevgr

EKSFRYWPrlgsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLT--GQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHtnstsdpqsPNP
 |  .|||      .| .|| .|..    .    . .  .....|     . |.| ..|.. ||.|. |   .|.|... .... . .          . 
vkClkyWP.....edtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.........eaG

PLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ
...|||||| ||||. |  .|..  .|...|.|.  .   ||.... .|.|  ||.|.| |...
rivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 907-1172 3.9e-30 99.6 In-house 31-280 (312) alignment 
Range on Protein: 907-1172
Range on HMM: 31-280/312.0
RLVDGECsTARLpENAERNRFQDVLPYDDVRVELVPtKENntGYINASHIKVSVSGIewDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREK
 . | || || |    . ||. ..  .|  |  |    ||   || |  .|.        ...|||||.|||  |||..   | . | ....  | | ||
ivsdsec.tafl.kfkdlnrypniqcwdrgrftlag.den..fyihanfvkictkpe..rfvctqgplentcthfwqlalslgstsiillcgfvedgsek

SFRYWPRLGSrhnTVTYGRFKITTRFRTDSGCYAT-------TGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEeiqSVRRHTNstsdpqs
. .|   . .    |     .. | . |.               ||.    ||||  . | |.. ||.|| |.     |  |    .|..  .       
cakyisdivg...fvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrlls...avkkdkk.......

pnpPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSSR
   |.. |||||||||| ..| | |||.| |    ..  .. .||..|   |... || .. |....|| |  
...pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg
subfamily_PTPN1_pd Subfamily PTPN1 908-1167 3.6e-54 178.5 In-house 19-270 (290) alignment 
Range on Protein: 908-1167
Range on HMM: 19-270/290.0
LVDGECSTARLPENAERNRFQDVLPYDDVRVELvptKENNTGYINASHIKVSvsGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKS
  | ....|.|||| ..||..|| |||  |..|   ..... ||||| ...    ..  || ||||| ||.. ||||||||    . |.    | .. | 
asdfptreaklpenrnlnryrdvspydhsrikl...eradndyinaslvele..eakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikc

FRYWPRLGSrHNTVTYG--RFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIqsvrRHTNSTSDPQSpnpPLL
..|||.  . ......   ..|..   . ..  |    |... | | . |.. |  || ||. | ||    ||..| ..    |.. | |. .    | .
aqywPqgee.ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkv....resGslssdvG...pav

VHCSAGVGRTGVVILSEIMIACLEHNEV---LDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQF
.|||||.||.| ..| . ... .|...    .|| .||  ||..|. |.||  |  | |  ... 
ihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 908-1169 9.8e-40 131.1 In-house 27-294 (301) alignment 
Range on Protein: 908-1169
Range on HMM: 27-294/301.0
LVDGECSTARLPENAERNRFQDVLPYDDVRVELVPTKE---NNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGR
  | .|.     ||.. |||... .||| |. | |...    .. |||||.|.   .  .  .||.|||...| .|||...|..  . | ||| ..|| .
gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgyse..kkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtk

EKSFRYWPRLGSRHNtvTYGRFKITTRFR----------------TDSG-CYATTGLKMKHLLtgQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIqsV
.|...|||.   ...  ..| |..|                      |.  |    .|.|.    . ..|  || ||||..|   . .  |  ....  .
skceqywpnseaese..efgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLqviddv..i

RRHTnSTSdpqspNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
 |   . .       |..||||..|.|.|| .  .| .     . | |.  |   .|....  |.|| |||..| |. ..|.
hrqq.kig.....ggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 908-1168 4.3e-36 119.5 In-house 29-277 (307) alignment 
Range on Protein: 908-1168
Range on HMM: 29-277/307.0
LVDGeCSTARLPENAERNRFQDVLPYDDVRVeLVPTKENNTGYINASHIKVSVSGieWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKS
  .|  ..  .  |...||.|||   |  |. .| ..   . || | .. ...      .|..||||.|| ..|| |. .. .  . |.    | .. | 
tpeg.vtveafsantdknryqdvkcqdkgri.vvkfdglasdyihanylgiaikp..kkficaqgplentqysfwamaiqekvesvimlckvielakikc

FRYWPRLGSR-------HNTVTYGRFKItTRFRTDSGCYATTGLKMKHllTGQERTVWHLQYTDWPEHGCPEDLkgfLSYLEEIQSVRRHTNstsdpqsp
 .|||    .        ||..   . .  ..  |  .   | ||..   ... ||. |||...||..|.|.     |. .. ...|| .||        
eqywpleegqklvfgeapntisvanlga.kklapdedlinvttlkvdw..aqksrtiqhlqwenwpdrgvpqin...ltainlleavrydtn........

npPLLVHCSAGVGRTGV-VILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL
  |..|||||||||.|  | .| ..   ..  .  |. .... ||.||   .||  || ...|||....
..pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 910-1164 4.8e-48 158.5 In-house 22-262 (283) alignment 
Range on Protein: 910-1164
Range on HMM: 22-262/283.0
DGECSTARLPENAERNRFQDVLPYDDVRVELVPTKEnntGYINASHIKVSVSG-IEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSF
| ..  |   || . ||.|...|.|  |||| .  .    ||||..| || |   . .||..|.||..| .|||.||... |. | |.|   |. |.|  
dldadiasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

RYWPRLGSrhntVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQER-TVWHLQYTDWpehgcpedlkgfLSYLEE--IQSV-RRHTNSTSDPQSPNPPL
.|||. ||    . || | .| |  | |  .    | ...  . ..   . | |. ||            |.| |.  | |. .     .   .|.. |.
qyWPkrGs....edyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW............leygeqaiinslvkfnkvislqteskkgPi

LVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVL
.||||.|.|||.| |     .  .  . |.|.. |. ..|.||||.|||| || .|. . 
vvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 910-1168 7.9e-28 92.2 In-house 24-270 (285) alignment 
Range on Protein: 910-1168
Range on HMM: 24-270/285.0
DGECSTARLPENAERNRFQDVLPYDDVRVELvptKENNTGYINASHIKVSVSGiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFR
  .|. .    | . ||. ||   .. || |   |. .  || || ...     .  ||.||||| .|  |||.|.... || . |. .  ||| ||   
ppnctytayeanpdlnryadvrcieetrvvl...knhdrdyihaswmrmpgkd.qstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcal

YWPR-LGsrhNTVTYGRFKITTRFRTDSgCYATTGLKMKHL-----LTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVrrhtNstsdPQspNPP
|.|  ||   . | .|...||     .  . | | |.   .      . .   . |.|   ||.. .||| . ..   . .. |    |    |.  . |
yypeklg...evvkfgkyeitlteckee.aiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv....n....pk..ekp

LLVHCSAGVGRTGVVILSE-IMIACLEHN--EVLDIPRvldMLRQQRMMLVQTLCQYTFVYRVLIQFL
. ||||||||||  ..  .   |  .|    |.||| |    .|  |.  ||.  |. |.| ||....
icvhcsagvgrtatfvgidyatirimenpniemldivr...emramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 911-1167 2.2e-21 70.7 In-house 37-278 (303) alignment 
Range on Protein: 911-1167
Range on HMM: 37-278/303.0
GECSTARLPENAERNRFQDVLPYDDVRVELvptkeNNTGYINASHIKVSVSGiewDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRY
 . |  .. .| ..||| ||.  |  .|.|      .. || ||....  |      | || ||. |. |||||. || .  . .. .. |  .      
psvsknqfvknmdknrfvdvicldhskvkl.....sdssyihasyleldssk...kailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsv

WPR----LGSRHNTVTYGRFKittrfrTdSGCYATTGLKMKHLLTGQERTVWHL-QYTDWPEHGCPED-LKGFLSYLEEIQSVRRHTNSTsDpqspnPPL
.||    |   . ..  | ||                ||.  .  |. ..  |. .| .||    | |    |.  . ..||| |.   .       |..
fprnqdflkfeersirvgefk......r.velgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysds.t.....ptv

LVhCSAGVGRTGVVILSEIMIACLE-HNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQF
 .   .|.||.|   | |     |   .  ||. ..|...|. |.  || |.|...|| .| . 
ym.slsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
0040439 (Phosphotyrosine protein) phosphatases II 912-1169 5.5e-75 247.4 In-house 2-247 (249) alignment 
Range on Protein: 912-1169
Range on HMM: 2-247/249.0
ECSTARLPENAERNRFQDVLPYDDVRVELVPTKE-NNTGYINASHIkvSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRY
|.|.|.|||| ..||..|.||||  || | .... . ..|||||.|  ... | ...|||||||..|. |||.|.||.|| .| |.| ..| |||| ..|
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi..dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPRlgsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTnstsdpqSPNPPLLVHCSA
||      ....||.|..|..  . .. | .. |....| .|..|||.|.||||||.||.|.... .|...|.........       ... |.||||||
wpl....ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.......pkggpvlVHCsa

GVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
||||||..|.  .|. .||..  .|.. ....||.||.. ||.. || |.|..|...|.
GvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 912-1169 4.7e-61 201.1 In-house 8-265 (270) alignment 
Range on Protein: 912-1169
Range on HMM: 8-265/270.0
ECSTARLPE---NAERNRFQDVLPYDDVRVELVPTKEN-NTGYINASHIKvSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKS
| |.  |||   ... ||..|.||    || | . .|. .| |||| ...  ..| .  |||..|||..| ..||.|.||.    |.|.|  || ||.| 
etsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvr.GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkC

FRYWPRLGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKhlLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSPNpPLLVH
 ||||    .. ....|  |...   . .  | .| |...   .|.|| . | .|..||.|| |..  . ||  . .. .|   .|... .  . |||||
erYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvH

CSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
|||||||||..|. .|.. .||... .|. .... ||..|| |||.  ||.|.|...... .
csaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
subfamily_eak_pd Subfamily eak 912-1170 2.9e-24 80.1 In-house 44-307 (332) alignment 
Range on Protein: 912-1170
Range on HMM: 44-307/332.0
ECSTARLpENAERNrFQDVLPYDDVRVELVPTKENNTGYINASHIKVsvSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYW
.  |||| |. .||   ...|||   |.| ... |. |||||| ..   | .   || |  . ..    ||||| ||    | ..  . | . ||| .|.
isetarl.eavnrn.vvkivpydrylvrltssqlnrlGyinaslaef..sevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

PRLGsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKHlltGQE-RTVWHLQYTDWPEHGCPE--DLKGFLSYLEEIQSVR------RHTNSTSDPQSPNP
|  .  .. . .| ......     . . |  |...    | |   | | ..  | |   |   |.  .   . |.  .          .||       |
pdkt..reelkfGildverkefvkrniletrllelsk...GnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlkkyihtp

P---LLVHCSAGVGRTGVVILSEIMIACLEH--NEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
|    .. .. |  |.|| .. ...|  ..   ...  .  ..   ...|.  | .  |..|.| .....|. 
psfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr
0042113 (Phosphotyrosine protein) phosphatases II 913-1169 1.7e-73 242.4 In-house 1-244 (245) alignment 
Range on Protein: 913-1169
Range on HMM: 1-244/245.0
CSTARLPENAERNRFQDVLPYDDVRVELVPTKENN-TGYINASHIkvSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYW
.|.|.|||| ..||. |.||||. || | |..... ..|||||..  ... |   .|||||||..|..|||.|.||.|| .| |.| ||| ||.|...||
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyv..dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqyw

PRlgsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHtnstsdpqSPNPPLLVHCSAG
|     ....|||.|..|..  .  . | .. |....| ....|.|.|..|..||.||.|..|. .|. ||.......         ..| |.|||||||
pl....gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae........dsngpvlVHCsaG

VGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
|||||..|.  .|. .||..  .... ....||.||.. |||. || |.|..|...||
vgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
0037934 (Phosphotyrosine protein) phosphatases II 913-1167 1.1e-66 220.2 In-house 2-241 (243) alignment 
Range on Protein: 913-1167
Range on HMM: 2-241/243.0
CSTARLPENAERNRFQDVLPYDDVRVELvptkeNNTGYINASHIKVSvsGiewDYIATQGPLQNTCQD----FWQMVWEQGIAIIAMVTAEEEGGREKSF
.|.|.|||| ..||..|.||||. || |     ....||||..|.|   .    .|||||||..|..|    ||.|.||.|| .| |.| ..| |||| .
fsiallpenlsknrysdilpydhsrvkl.....egsdyinanliyvt..p...rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

RYWPrlgsrhNTVTYGRFKITTRFRTDSGCYATTGLKMKHLL-TGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNsTSDPQSPNPPLLVH
.|||      ..||||.|..|.   .  . |  . |....|  ....|.|.|..|. ||.||.|.. . .|..|.|.... . .. .    ... |.|||
qywp......gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieell.sllaldsggpvlVH

CSAGVGRTGVVILSEIMIACLehNevLDIPRVLDMLRQQRMM-LVQTLCQYTFVYRVLIQF
|||||||||..|.  .|. .|  .  .|.  ....||.||..  |||. || |.|..|...
CsaGvgRtGtliaaylmllll..g..vdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 913-1166 2.1e-47 156.6 In-house 41-277 (315) alignment 
Range on Protein: 913-1166
Range on HMM: 41-277/315.0
CSTARLPENAERNRFQDVLPYDDVRVEL-VPTKENNTGYINASHIKVSVsgIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYW
  .|.  || ..||. ....||  ||.| .  ..... |.||. |.      .  |||.|||. .. .|||..|.|. |. | |.|   || ..|. .||
ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGyn..kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekyw

PRLgsrhnTVTYGRFKITTRFRTDSGCYATTGLkmKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYleeIQSVRRH-TNSTsdpqspnPPLLVHCSA
|        |.||.. .| .       |.   |        . |.|  |.|| ||. | |.    .. .   |. |..| |||         ...|||||
pdk.....kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnl...irtvkqhhtnsv.......gaivvhcsa

GVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ
||||||  |  . ..  .| ....|. ...  .||.|. .||.. || |.| .|..
GvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 913-1167 7.2e-32 105.2 In-house 29-268 (281) alignment 
Range on Protein: 913-1167
Range on HMM: 29-268/281.0
CSTARLPENAERNRFQDVLPYDDVRVELVP--TKENNTGYINASHIKVSVsgIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRY
|..   | | ..||. ..   |  ||.|     ..| | || | .|.  .  ..  || |||| ..|  |||.|.|..  . | |.    |  |||   |
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf..lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaey

WPRlgSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHllTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSvrRhtnSTsdpqspnPPlLVHCSA
.||    |  . . .. ..    |      || |.. .   |. | . |  . .||.   ||  . .|  | .|..  |   ||       || ..||||
fpr..nahcclqfdklsvsyedstvnkslvttrlnlsy..egetrlithwlwkewpdwqvpessevmlkilrkira..r...st.......pp.vihcsa

GVGRTGVVILSEIMIACL-EHNEVLDIPRVLDMLRQ-QRMMLVQTLCQYTFVYRVLIQF
||||.| ..  || .  .  |  . || ...  ||   |   |||| || ....||..|
gvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 913-991 7.3e-11 36.2 In-house 29-111 (347) alignment 
Range on Protein: 913-991
Range on HMM: 29-111/347.0
CSTARLPENAERNRFQDVLPYDDVRVELVPTKENN------TGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIA
....    . ..|| .||   |. || | | | .|       .||||||||   .  . .|| || || .| .|||.||    ..
ftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdna..skeyiltqyplpdtvrdfwkmvsvtkvt
subfamily_PTPN12_pd Subfamily PTPN12 914-1170 5e-63 207.7 In-house 33-279 (290) alignment 
Range on Protein: 914-1170
Range on HMM: 33-279/290.0
STARLPENAERNRFQDVLPYDDVRVELVPTKENN-TGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWP
.... .|| ..||..|.||||  ||||  ..|..  .||||..|| . .  .  |||.|||| .| .|||.|.||. . |. |.  | | |. |  ||||
eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgveg..kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

RLGsrHNTVTYGRFKITTRFRTDSG-CYATTGLKMKHLltGQERTVWHLQYTDWPEHGCPEDLKGFLSYleeIQSVRRHTNstsdpqSPNPPLLVHCSAG
  |  ......| |..|.         .    ||...   ...|.|  ..||.||.||.|.  |  |.    |..||.. .      | . ||.||||||
eeg..eeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllel...ielvrelqe......sedaPlvvhCsaG

VGRTGVVILSEIMIACLEHNEV---LDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
|||||..|  ...   |... .   ||.  ..  ||.||  ||||  ||..||. .......
vGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 914-1169 2.3e-53 176.1 In-house 37-278 (315) alignment 
Range on Protein: 914-1169
Range on HMM: 37-278/315.0
STARLPENAERNRFQDVLPYDDVRVEL-VPTKENNTGYINASHIKvSVSgIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWP
 .|| ..| ..||....||.|  || | |  .. .  |||||.|| ||   .  |||.||||. . .|||.||... .. |.|||  .|| . |  .|||
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyik.svd.ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

RlgSRHNTVTYGRFKITTrFRTdSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKgflSYLEEIQSVRRHtNstsdpQSPNPPLLVHCSAGV
    . ..| .| .|... . . . .  ..  |.    . . |||   |.|.||..| ....    | |. |. |.   |     .. . .|||||||||
d..rkadsvefGsikvel.lsl.eadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqts...sllklikevkad.n.....gkkefsllvhcsaGv

GRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
|||||||  . ..| .......|. ... .||..|. ||||  .|.|.| .. . |.
GrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 914-1170 5e-43 142.5 In-house 41-290 (325) alignment 
Range on Protein: 914-1170
Range on HMM: 41-290/325.0
STARLPENAERNRFQDVLPYDDVRVELVPTKEN-NTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMV--WEqgiAIIAMVTAEEEGGREKSFRY
 .| .||| ..|||..|...|  || |.  |.. .. |||||...  .      ..|.| || .| .|.|..|  |.   . . .|. | ..| ..   |
kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkk..kdvflaaqaPltatindlWrlvldWr...csvvvvlneldlgkdrcavy

WPRlgSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPqspNPPLLVHCSA
||.     ...|.| ...  |   .   |    |..|    |. |.|  .|.  |.. | ..    ..|.|. .. |    .. .       |.||||||
wpk..emgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantka...stpilvhcsa

GVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
||||||| |    ..| . ..  .||  ..  ||..|  .|.|  ||...|  |.... |
GvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveayms
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 914-1166 4.1e-39 129.1 In-house 38-234 (392) alignment 
Range on Protein: 914-1166
Range on HMM: 38-234/392.0
STARLPENAERNRFQDVLPYDDVRVEL-VPTKENNTGYINASHIKvSVsGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGreksfrywp
..|. . | ..||....||||  || | |    ... |.|||.|. |.   |  |||.|||   . .|||.||... .. |||||  .||          
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyip.sf.dnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd.........

rlgsrhntvtygrfkittrfrtdsgcyattglkmkhllTG-QERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSvrRHTNSTsDpqspnpPLLVHCSAG
                                       | . |||   ..|.||... |.    .| ...|...   . . |        ||..|||||
......................................kgddartvaqfhftewPdkdvpkhtssllkfikevka..dfGqyt.h......pliihcsag

VGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ
||||||||  . ..|  ..  ..|.  ..  .|..| ..|||  ||.|.|  ...
vgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 914-1158 2.5e-26 87.2 In-house 45-271 (301) alignment 
Range on Protein: 914-1158
Range on HMM: 45-271/301.0
STARLPENaeRNRFQDVLPYDDVRVELVptKENNTGYINASHIKVSvsGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPR
| | ||..  ..|.. |    .  ||..  .. .   | |  |. |  |    .|||||||.||..||| |.    .  |.|.. . |   ||   | | 
syaylpkd..khryptvPckPstavevi..vdGkrvPihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpv

LGSrhNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLT---GQERTVWHLQYTDWPEHGCPedlKGFLSYLEEIQSVRRHTNstsdpqspnpPLLVHCSA
  |  ...  |||||... .       ..  ...   .    . ||| | ||..|...| |   |.     . .. |..  .          |..|||||
kis..ekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvP...kshaelfdlmelvkksek..........Pivvhcsa

GVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYT
|.||.   | .|..   .| .  ... . |  ||..|   |||  |  
GiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqly
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 915-1170 4.6e-56 184.8 In-house 3-244 (250) alignment 
Range on Protein: 915-1170
Range on HMM: 3-244/250.0
TARLPENAERNRFQDVLPYDDVRVELVPTK-ENNTGYINASHIKVSVSGieWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREkSFRYWPR
 |. |.| |.||. |....|  || | ..| .... |||||....        .||||||||.| .|||.||.|. .. | |.|  .| ...   .||| 
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder..kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

lgsrHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSvrrhtnstSDPQSPNPPLLVHCSAGVG
     .. .||  ...   .   . | .. ||. .    .||.| .|... ||. | ||  .  | .|...|.        |..|. | |..|.||||||
....ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqa........sqqqagnaPvivqCsaGvg

RTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
|.|  |  . ..  |....|.|. .|. .||..|.  |..| || |||......|.|
rsGafiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 916-1170 1.8e-58 192.8 In-house 23-270 (274) alignment 
Range on Protein: 916-1170
Range on HMM: 23-270/274.0
ARLPENAERNRFQDVLPYDDVRVELVPTK--ENNTGYINASHIKVsVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPR
 ... ....||....|| .  || | . .  .... |||| .||   .. .  |.||||||.|| .|||.|.... . .| |.|  .|  ..|  .|.| 
ldvfgsqtknryktilPnensrvllesessededssyinanyikG.ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPd

LGSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTgqERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQspnpplLVHCSAGVG
  . . . .|| ..|...  ..   |  . | .|.|    ||.| |  |||||.|  |.| . .|. ..|... |...|    |.      .||||||.|
aedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapv......vvhCsaGiG

RTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
|||. |  .| .  |....|.|. ..   ||..|  .|||  || ...|.|...|| 
rtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 917-1012 9.9e-12 39.0 In-house 92-179 (244) alignment 
Range on Protein: 917-1012
Range on HMM: 92-179/244.0
RLPENAERNRFQDVLPYDDVRVELVPTKENNTgYINASHikVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGreksfRYWP
  |.|. .||    ||.|  || |      || |||||   |   |   .|| || || .|  |||.|. |. . .. .. . ||        |||
fnpnnswknregaglpfdfnrvplskgsmgnt.yinasf..vgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywp
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 919-1171 6.8e-49 161.4 In-house 45-281 (287) alignment 
Range on Protein: 919-1171
Range on HMM: 45-281/287.0
PENAERNRFQDVLPYDDVRVELVptkENNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRlgsrH
..| ..||....|..|. || |    ...  ||||..|.   .  .  .|....|. || ..||...... . .| |.. |.|  .|. ..|||     .
sqnkdknRltqilvpdnyrvllk...gehpdyinavfidgyke..kkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpe....e

NTVTYGRFKITTRFRTDSGCYATTGLKMKHLL-TGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNstsdpqspNPPLLVHCSAGVGRTGV
..|..| ..|.   .. .  |    |..|.   .|....|   |.|.|...|  .. .  |  .||    .|.          | ...||||..|||...
ksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrg........ntsivvhCsdtvGrsam

VILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKSS
 .  .. |   . . |.|. .||.  |.|..  |||  ||.|.. .....|.| 
fcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 920-1170 4.2e-51 168.8 In-house 50-286 (297) alignment 
Range on Protein: 920-1170
Range on HMM: 50-286/297.0
ENAERNRFQDVLPYDDVRVELVPTKEN-NTGYINASHIKVSVSgiewDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGReKSFRYWPRLGsrh
 | |..|....||||  ||.|  . .. .  |.|||..|.        .|.|| | ..| .|||.||... ...|.|.. ..|. . |  |||.  |   
vnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkg...

nTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPE--DLKGFLSYLEEIQSVRRHTNStsdpqSpnpPLLVHCSAGVGRTG
 ..|.|   ...   ..   .    |....  . ..| |   |...||..  ..  . . .| ...|.. .  ....     .   ||||||.|||||||
.vttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnae.....g...PllvhclaGvGrtg

VVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
|..  . ..|  .... .||  .. .|||.|. ||||  ||.||| .....| |
vlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 920-1170 1.3e-48 160.2 In-house 37-279 (287) alignment 
Range on Protein: 920-1170
Range on HMM: 37-279/287.0
ENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRlgsRHN
 ....||. ||||.|| || |. . |  . |||| ..       .  .||.|||.  | .|||..|.|.  | ....| | | .| | ..|||    |. 
aavkknryadvlPiddtrvllsaegelGsdyinanyvasytd..deafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPe...rev

TVTYGRFKITTR-FRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYleeIQSVRRHTNSTSDPQSpNPPLLVHCSAGVGRTGVV
 .  | . ..   .   .  |..  |.. .| | . | |  |.. .||... .    |.. .   . .|..| . . | .    ||.||...|.||.|..
PmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirf...vldvkqhielardase.vGPlvvhddvGiGrsGil

ILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
.   ...  ||    .|. .|.  ||..|  |||.  |. ..|  |. . |.
latlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 920-1164 5.3e-43 141.9 In-house 2-235 (237) alignment 
Range on Protein: 920-1164
Range on HMM: 2-235/237.0
ENAERNRFQDVLPYDDVRVELVPTkENNTGYINASHIKvSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPrlgSRHN
||  .||. ..  ||  || |  .  ... ||||...| .. |    |||.||||...|.|||||||..  ..| |.|   || ..|  .|||   | ..
enkiknrygnivaydhsrvvlkga.gsgsdyinatylk.gfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp...stdq

TVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQE-RTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSdpqspnpPLLVHCSAGVGRTGVV
  .|| . .. . . .   |.   | . . || .| | ..  |.| ||..| |.    .| .  .|    .| . ..       | ..||||||||||..
paaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesg.......pwiihcsagvgrtgif

ILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVL
.. . |.   . ..|.||   .  . ..|  ..||  || |.....
lvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 920-1168 2e-30 100.8 In-house 42-271 (288) alignment 
Range on Protein: 920-1168
Range on HMM: 42-271/288.0
ENAERNRFQDVLPYDDVRVELVptkeNNTGYINASHIkVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRlgSRHN
.|. |.|....   |  || |     ... .  |... || .  .   | .| ||. | . .|.|. |...  | |..   | |.|||  |.|      .
anptrdryenlprcditrvkls....ddpdfyiaanv.vssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPs..klGe

TVTYGRFKITTRFRTdSGCYATTGLK-MKHLLTGQERT-VWHLQYTDWPEHGCPEDlkgFLSYLEEIQSVrrhtnstsdpQSPNPPLLVHCSAGVGRTGV
.. .||.   .. .  ..   .  .  ..   .|.|.  | .| . .|...| ||.   .||.|  .. .          .| . |..||.|||||||| 
karigrlctvvkkkr.adidklvkvsllriskegeekvivkilhlleWdddgvPen...ylsplrllevl..........kslqkPivvhssaGvGrtgt

VILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL
.||. |..  |  .. | |...|  ||..|.  .||  || .|.|.. . |
lililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 920-1169 8.7e-28 91.8 In-house 51-291 (310) alignment 
Range on Protein: 920-1169
Range on HMM: 51-291/310.0
ENAERNRFQDVLPYDDVRVELVPTKENNTGYINASHIKVSVsgIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSrhn
..  .||. ||.  |. || |   |     || | ..|     .   .| .||||| |  |||.|....    | ..    | || |.  ||| ||    
kymhknrysdvvcldtsrvklkidksryedyihanyvktny..lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgv...

TVTYGRFKITTrFRTDSGCYATTGLKMKHL-----LT-----GQERTVWHLQYTDWPEHGCPEDlKGFLSYLEEIQSVRrHTnstsdpqspnpPLLVHCS
| |||  ..|  .   |  .    | .  .     .       .|  |  ... .||. | |.. |        .  || |            | .||||
tetygcirvtn.lsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde.kchtvpqrllaqvr.hg...........pcvvhcs

AGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
||..|..||.  .. |  |.. . .|.  |   |...|.. .||  ||... || | | .
agkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifar
subfamily_CG42327_pd Subfamily CG42327 920-1087 1.1e-24 81.7 In-house 27-193 (319) alignment 
Range on Protein: 920-1087
Range on HMM: 27-193/319.0
ENAERNRFQDVLPYDDVRVELVPT-KENNTGYINASHIKVSVSGiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRH
   ...|. .|.|  . || |    ..... |..||...   .  .  |||.| .|...  |||..||||   .|  .|   | | ..  .|.|   .  
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGydda.pnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketld

NTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYtDWPEHGCPEDLKGFLSYLEEIQSV
|| .|| ...| . |     ||.. | .|..   . | . |  | .|.| . | . . ... | |..| 
ntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_egg_pd Subfamily egg 920-1169 4.9e-23 76.3 In-house 39-271 (307) alignment 
Range on Protein: 920-1169
Range on HMM: 39-271/307.0
ENAERNRFQDVLPYDDVRVELV-PTKENNTGYINASHIKvsVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGgrEKSFRYWPRLGSRH
.| |. | . |   |  ||.|  .       .| | ..|     .  ..| .| ||.|| .|||.||... .  | |.|.  |   |.   |||.  |  
nnlekarskrvhckdssrvklelrrGqylddfihanrvk..Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaesds

NTVTYGRFKITTrFRTDSGC---YATTGLKMkhllTGQERTVWHLQYTDWpehgcpeDLKgFLSYLEEIQSVRRHTNSTSDpqspnpPLLVHCSAGVGRT
  .  | ..|.. .. ||     .  | ||.     | ..   .|..  .       |.. ..| .     | |.    |       | .|..  || ..
lvtvpGslrien.lkvdskadplfrvtklkl....vGgddeerflehwqg.......dvn.nssdvysplrvlrklrnlsk......pvvvqdilGvska

GVVILSEIMIACLEHNEVL--DIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
....  || .  |    .    . |   .||..| . |..  .| ||||... |..
atlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffr
Y_phosphatase Protein-tyrosine phosphatase 921-1165 1.1e-72 239.6 Pfam-A 1-234 (235) alignment 
Range on Protein: 921-1165
Range on HMM: 1-234/235.0
NAERNRFQDVLPYDDVRVELVPTKENNTgYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPrlGSRHNT
| ..||..|.||||. ||.|  .....  ||||...|   .  .  .|||||||..|..|||.|||.. . .|.|.| .|| ||||  .|||   .....
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp..eeeees

VTYGRFKITTR--FRTDSGCYATTGLKMKHLLTGQ-ERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRrhtnstsdpQSPNPPLLVHCSAGVGRTGV
.|||..|....    .|.  |... |..|.  . . .|.|..|.||.||.||.||. |..|........ .         .. . |..|||||||||||.
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.........eaksgpvvVhCsaGvgRtgt

VILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLI
... .|.. .||..| .|.  .. .||.||...||.| || |.|....
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 921-1165 1.1e-72 239.6 In-house 1-234 (235) alignment 
Range on Protein: 921-1165
Range on HMM: 1-234/235.0
NAERNRFQDVLPYDDVRVELVPTKENNTgYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPrlGSRHNT
| ..||..|.||||. ||.|  .....  ||||...|   .  .  .|||||||..|..|||.|||.. . .|.|.| .|| ||||  .|||   .....
nkkknRykdilpydktrvklkgsegpsd.YInAnyvkgyke..kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp..eeeees

VTYGRFKITTR--FRTDSGCYATTGLKMKHLLTGQ-ERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRrhtnstsdpQSPNPPLLVHCSAGVGRTGV
.|||..|....    .|.  |... |..|.  . . .|.|..|.||.||.||.||. |..|........ .         .. . |..|||||||||||.
ltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.........eaksgpvvVhCsaGvgRtgt

VILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLI
... .|.. .||..| .|.  .. .||.||...||.| || |.|....
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 921-1169 1.7e-54 179.8 In-house 43-277 (515) alignment 
Range on Protein: 921-1169
Range on HMM: 43-277/515.0
NAERNRFQDVLPYDDVRVEL-VPTKENNTGYINASHIKvSVSgIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSrhN
| ..||....|||| ||| | |   . .  |.|||.|. |.   .  |||.|||.. . .|||..|... .. |||||  .|| . |  .|||   .  .
nfkknryknilPydsvrvklevindnPhsdyfnasyip.sfd.ndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg..d

TVTYGRFKITTRfrTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSvrrHTNSTsdpqspNPPLLVHCSAGVGRTGVVI
.| .| .|. .   . . |  ..  |.. |   . |||   ..|.||..| |.. . .| .. |...    ..        . ||..|||||||||||||
svkfGsikvelv..sleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevka...dhgqy......thpliihcsaGvGrtGvvi

LSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
  . ..|  .  ...|. ...  .||.|. ||||  ||.|.| .. . |.
sidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
0041856 (Phosphotyrosine protein) phosphatases II 921-1169 1.3e-43 144.0 In-house 1-172 (182) alignment 
Range on Protein: 921-1169
Range on HMM: 1-172/182.0
NAERNRFQDVLPYDDVRvelvptkenNTGYINASHIKVSVSGIEwdYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTaeeeggrekSFRYWPrlgsrhnt
| ..||..|.||||  |         .  ||||. .  |  . .  .|||||||..|. ||..|..|.|| .| ..|         ...|||        
nldknrysdilpydhsr.........dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

vtygrfkittrfrtdsgcyattglkmkhllTGQERTVWHLQYTDWPEHGCPEdLKGFLSYLEEIQSvrrhtnstsdpqsPNPPLLVHCSAGVGRTGVVIL
                              .  ||......|. || ||.|. |  .|...||...             .. | ||||||||||||....
..............................ellerlgiqylylpwpDhgvpd.ldelldfieevle.............eggpvlVHCsaGvgRtgtlva

SEIMIAClehnEvLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
  .|. .    . .... .....|..|.. |.|. || |....| ..|.
aylmkkl....g.vsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 921-1166 2.2e-40 133.4 In-house 48-277 (439) alignment 
Range on Protein: 921-1166
Range on HMM: 48-277/439.0
NAERNRFQDVLPYDDVRVEL--VPTKeNNTGYINASHIKVSVSgiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEggrekSFRYWPrlgsRH
.  .||..|| ..|  || |  .|     . |||| .||      .  ||||||| ..|..|||..|.|.  . | |.|   |     |..|||      
dqtknrykdvgafdhtrvtlqeipgv.phshyinanyikGyyd..dklyiatqgpkkettddfwrlviekktvtivmltnlve.....sykywp....sd

NTVTYGRFKITTRFRTDSGCYATTGLKM--KHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLeeiqsvrRHTNSTSDPQSpNPPLLVHCSAGVGRTG
. | ||   . .    .   |.  |.|.  ..  | .|||| ...|. ||..  | .    | .|       |  ||. | .    |..|||||||||||
aevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldfl.......rainsandkee.ygpvvvhcsagvGrtG

VVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ
 .|  .| .  |  .. .||  .. .||.||  .||.|||| |.|  ...
tiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 921-1162 2.4e-34 113.6 In-house 8-235 (239) alignment 
Range on Protein: 921-1162
Range on HMM: 8-235/239.0
NAERNRFQDVLPYDDVRVELVPT-KENNTGYINASHIKvSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPrlgsrHN
|  .||. ... ||  || |    ..  . |||||...    |    |||||| .. .. |||.|.|..  ..| |.|   || ..| ..|||      .
nkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.....ds

TVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEdlkgflsYLEEIQSVRRHTNSTSDPQspNPPLLVHCSAGVGRTGVVI
|  |  ...| |       |    . | ..   .|| |.. ..| ||..| |.       |   .  .||.    | |     | ..|||||||||| ..
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpq.......yatavlglrrkitkdslpg..arpwvihcsagvgrtgafl

LSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYR
. . |.   .... .||   .  .|..|  .|||  || |.. 
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 921-1163 2.4e-34 113.6 In-house 7-235 (239) alignment 
Range on Protein: 921-1163
Range on HMM: 7-235/239.0
NAERNRFQDVLPYDDVRVELVPT-KENNTGYINASHIKvSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPrlgsrHN
|  .||. ... ||  || |    ..  . |||||...    |    |||||| .. .. |||.|.|..  ..| |.|   || ..| ..|||      .
nkaknryanivtydhsrvvleklsndphsdyinasylr.dydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.....ds

TVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEdlkgflsYLEEIQSVRRHTNSTSDPQspNPPLLVHCSAGVGRTGVVI
|  |  ...| |       |    . | ..   .|| |.. ..| ||..| |.       |   .  .||.    | |     | ..|||||||||| ..
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpq.......yatavlglrrkitkdslpg..arpwvihcsagvgrtgafl

LSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRV
. . |.   .... .||   .  .|..|  .|||  || |..  
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihla
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 921-1170 4.2e-31 102.7 In-house 54-285 (290) alignment 
Range on Protein: 921-1170
Range on HMM: 54-285/290.0
NA--ERNRFQDVLPYDDVRVELVPTkeNNTGYINASHIKvsvsGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRlgSRH
|.  ..||..||   |  || |      .  |. | ..|    |..  .| |||.|..|  |.|.|| ....| | |.    | |. |  .|.|      
ntefkknrykdvvcndktrvilkdG..ydGdyvhanyvk....GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyype..keG

NTVTYGRFKITTRFRTDSGCYA-TTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDlkgFLSYLEEIQSVRRHTNstsdpqspnpPLLVHCSAGVGRTGV
...|.| . ..    .|         | ...  .|.|  . ||.   ||..  .      |. |  ....|. .           |. ||||||.|||| 
evltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvals...tlallrtlrilrkasG..........pvvvhcsaGiGrtGt

VILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
 .  |. . .| .   ||.  .   ||. |.  ||   ||  . ..|... |.
fvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkd
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 922-1168 1.4e-30 101.0 In-house 56-289 (305) alignment 
Range on Protein: 922-1168
Range on HMM: 56-289/305.0
AERNRFQDVLPYDDVRVELvpTKENNTGYINASHIKVSVSGiEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNTV
  .||.|||   |   | |   | . . || | .. . .   |  .|..||||..| ..|| || .. .  | |.    | |. |  .|||     . ..
itknryqdvpcqdqsavkl..dkpspsdyihanyvgcpmip.ekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklel

TYGRFKI----TTRFRTDSGCyATTGLKMKHlLTGQERTVWHLQYTDWPEHGCPEdlkGFLSYLEEIQSVRrhtnsTSdpqspNPPLLVHCSAGVGRTGV
  |        .  .  |.     | |.. .   .|. .| |||.|.||. | |      |. || . ..|      |     . |..||||||.|||| 
ksgivvenvsgskpmerdaei.qitllnlty.sgdqkmsvrhlqwtewpdrgvpp...ckltslellsair.....gs.....kvpivvhcsagigrtgt

VILSEIMIA-CLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL
..  | ..    | ...  .| ..  ||.|| . .|.  || |..||.....
ivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 922-1022 5.3e-23 76.3 In-house 48-161 (350) alignment 
Range on Protein: 922-1022
Range on HMM: 48-161/350.0
AERNRFQDVLPYDDVRVELV----PTK-----ENNTGYINASHIKVSVSGIE----WDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSF
  .||....|||.  ||.|     ...      .   ||||...|... ..|    . |||||.||..| .||.... . .. .| ..|.. | ..||  
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

RYWPRLGSRHNTVT
|||....    || 
rYWqegsydditvk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 923-1016 1.1e-11 38.6 In-house 50-158 (349) alignment 
Range on Protein: 923-1016
Range on HMM: 50-158/349.0
ERNRFQDVLPYDDVRVELVPTKEN---------------NTGYINASHIKVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKS
 .||..|.|||.  || |  . ..                  |||| ..|..   .|  ||||| ||  | .||....  .|. ..  .. ..| . || 
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

FRYWPRLGS
 .||  |  
diywqelsy
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 931-1013 1.4e-07 25.9 In-house 3-71 (130) alignment 
Range on Protein: 931-1013
Range on HMM: 3-71/130.0
LPYDDVRVElvptkenNTGYINASHikVSVSGIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGreksfRYWPR
|...  |..       .  |||||   | ..|   .|. || || .|. |||.|. |. . .. .. . ||        ||| 
lefevsrlq.......gntyinasf..vGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed.....eywpd
0044763 (Phosphotyrosine protein) phosphatases II 932-1169 1.4e-29 98.4 In-house 1-172 (178) alignment 
Range on Protein: 932-1169
Range on HMM: 1-172/178.0
PYDDVRVELVPTKENNT-GYINASHIKvsvsgiEWDYIATQGPlqntcQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSrhntvtygrfkitt
|.|. || | .    ..  |||||.|       .  |.....|     .|......|.||  | ..| | |.|..|...|||.  .              
pldrtrvllsnleglersdyinaseil......pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..............

rfrtdsgcyattglkmkhlltgqertvWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRrhtnstsdpQSPNPPLLVHCSAGVGRTGVVILSEIMIACleh
                           .. ... .| ||.|. |. ||  .| |....         .... | ||||||||||.|....  .|. .   
...........................iqylhipipDhgvpdllehflefvefieeal.........dekggpvlVHCsaGvgRsgtlvaaylmkkl...

nEVlDIPRVLDMLRQQRMmLVQTLCQYTFVYRVLIQFLK
  . ... .....|..|.  |..  |. ..|..  ..||
.gl.sleeaielvrerRp.ivpnpgqlrqLyefelrllk
0046846 (Phosphotyrosine protein) phosphatases II 943-1169 2.4e-37 123.7 In-house 7-174 (176) alignment 
Range on Protein: 943-1169
Range on HMM: 7-174/176.0
TKENNTGYINASHIKVSVsgiewdYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSRHNtvtygrfkittrfrtdsgcyatt
. ...  ||||. |  |       .||||||| .|..||..|..|.|| .. ..| | | || | ..|||.| . .                        
gldldldyinanlilgsr......piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.......................

glkmkhlltgqertvwHLQYTDWPEHGCPEDlKGFLSYLEEIQSVRRHtnstsDpqspnPPLLVHCSAGVGRTGVVILSEIMIAclehNEVLDIPRVLDM
                . ....||.||.|.. . .|. ||.|......     .      | |||||||.||||....  ...     .  |..  .|..
................qylhlpwpDhgvpdl.elllellefirealke.....g.....gpvlVHCsaGigRtgtlvaayllel....ekglsveealal

LRQQRM-MLVQTLCQYTFVYRVLIQFLK
.|.||. . ||| .|| |.|... ..||
vreqRplgavqtpeQyrflyefellllk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 944-1165 8.7e-12 39.8 In-house 42-256 (290) alignment 
Range on Protein: 944-1165
Range on HMM: 42-256/290.0
KENNTGYINASHIKVSvSGIewDYIATQGPLQNT-------CQDFWQMVWEQGIAIIAMVTAEEEGGREKSF----RYWPRlgSRHNTVTYGRFKITTRF
|  | .|| |...... .|.    |.|| |....        ..|| |. .  .  . |.   ||  ...|     .| |   |  . .... ...    
krfnddyiHAnrvtcp.ngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpe..svgeelkfkgltvkCks

RTDSGCYATTGLKMKHlLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQsvrrhTNSTsdpqspnpPLLVHCSAGVGRTGVVILSEIMIACLE-HN
.       |  | .|.   ..| || | .. .| .   .|| | .|| .. ..     .. |        | .|||  |. |  ..  ...    .   .
kekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvk.....askt........pvivHcvdGiSrsAalaaiilgyQkiaets

EVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLI
. . .  ||..||.|| .....  ...||  ...
gsvkledvlkalrkqralaitsalelafvdagiv
0043147 (Phosphotyrosine protein) phosphatases II 945-1161 1e-39 131.4 In-house 2-154 (172) alignment 
Range on Protein: 945-1161
Range on HMM: 2-154/172.0
ENNTGYINASHIKVSVsgIEWDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEeeggreksfrywprlgsrhntvtygrfkittrfrtdsgcyattgl
.... |||||......  | ...|||||||.||. |||.|..|.|| .| ..| .                                             
degsdyinasyldlyy..ipdrfiatqgplrntladfwrmlkelgithivnltel.............................................

kmKHLLTGQERTVWHLQYTDWPEHGCPeDLKGFLSYLEEIQSVR--RHtnstsdpqspNPPLLVHCSAGVGRTGVVILSEIMIaclehnEVLDIPRVLDM
   .. .. ||......|. || ||.| .|. .|. || |...   .           . | ||||||||||||....  .|.      . |..  ....
..lydpellerlgiqylylpwpDhgvp.llellleflefidellalsp..........ggpvlVHCsaGvgRtgtlvaaylml......lglsleeaval

LRQQRMMLVQTLCQYTFVY
.|..|.. ||.  || |.|
vrekRpgavqnpsqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 947-1169 3.6e-48 159.9 In-house 3-226 (272) alignment 
Range on Protein: 947-1169
Range on HMM: 3-226/272.0
NTGYINASHIKVSVSGIEWD-YIATQGPLQNTCQDFWQMvWEQGIAIIAMVTAEEEGGREKSFRYWP--------RLGSRHNTVTYGRFKITTRFRTDSG
 .|||||....   . . .. .....|||..|..|||.. .|.||  | ... ||| ||.| .||||         |.. . |..||.. .|. . .   
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

CYATTGLKMKHL-LTGQERTVWHLQYTDWPEHGCPEDLkgFLSYLEEIQSvrrhtnstsdpqspNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLD-
.|  . | ...|  .|. |.|.||.||||| || |..   .|. ||....              . |.|||||||..|||.|..  .... .... ..| 
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld..............ggpvlvHCsaGkdRTGtvvallllllgvsletivdd

-------IPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
       . .....||.||.  |||  || |.|..|...|.
Ylltnlyleeaveelraqrpgavqteeqylflyeallellr
0051082 (Phosphotyrosine protein) phosphatases II 948-1164 3.8e-31 103.1 In-house 3-149 (151) alignment 
Range on Protein: 948-1164
Range on HMM: 3-149/151.0
TGYINASHIKvsvSGiewdYIATQGPLQntcqDFWQMVWEQGIAIIAMVTAEEEGGreKSFRYWPRLGsrhntvtygrfkittrfrtdsgcyattglkmk
..|||.| .    .|    .....|||.    ||.....|.||  | ... ||| |  .  .|.|.||                                
sdyinfsyvt...gg....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

hlltgqeRTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSvrrhtnstsdpqSPNPPLLVHCSAGVGRTGVVILSEIMIAClehnevLDIPRVLDMLRQQR
       ..|.|....|||..|.|. .. .|..||....             .| |.|||||||.||||....  .|.        ...  .|...|..|
.......ievlhipildwpdpglplsfdavleflellld............kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkr

MMLVQTLCQYTFVYRVL
...||.  |. |....|
pgvvqpnqqflfqlfal
0036282 (Phosphotyrosine protein) phosphatases II 949-1162 3.8e-40 132.8 In-house 3-164 (174) alignment 
Range on Protein: 949-1162
Range on HMM: 3-164/174.0
GYINASHIKVSVSGIewDYIATQGPLQntcqdFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRlgsrhntvtygrfkittrfrtdsgcyattglkmkh
 |||||....|.      .||.||||.     ||.|..|.|| .. |.. |.| |..| ..|||.                                   
dyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

LLTGQERTVWHLQYTDWPEHGCPEDLKgFLSYLEEIQSVRRHtnstsdpqSPNPPLLVHCSAGVGRTGVVILSEIMIACLEhNEVLDIPRVLDMLRQQRM
| .  ||......|. || ||.|.. . .|. ........ .        .|. |.||||||||||||....  .|. .|. . . |. ... .||.||.
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse........dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrp

MLVQTLCQYTFVYR
. |||  || |.| 
gmvqtpsQyrflyy
0049260 (Phosphotyrosine protein) phosphatases II 965-1161 5.1e-34 112.5 In-house 9-143 (152) alignment 
Range on Protein: 965-1161
Range on HMM: 9-143/152.0
WDYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWprlgsrhntvtygrfkittrfrtdsgcyattglkmkhlltgqertvwHLQYTD
. .||||||. ||. |||.|..|.|| .| |.| ..| |..|  .|.                                               . ... 
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...............................................qylhlp

WPEHGCPEDLKGFLSYLEEIQSVRRHTNStsdpqspnpPLLVHCSAGVGRTGVVILSEIMIaclehnEVLDIPRVLDMLRQQRMMLVQTLCQYTFVY
|| ||.|..   .|  |. |.  ... .          | ||||||||||||....  .|.        ...  .....|..|.. |..  |. |.|
wpDhgvpdlsqlllflllfieklaldkgg.........pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 966-1163 1.2e-26 88.1 In-house 6-199 (199) alignment 
Range on Protein: 966-1163
Range on HMM: 6-199/199.0
DYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSrhNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTG--QERTVWHLQYT
 ||||| ||..|  |||||||| |   | ||  ..         |||   |   |  || . .||.  |    |. | | .    |     | . | |.|
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttes..gtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPEHGCPEdLKGFLSYLEEIQSVRRHTNstsdpQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHN--EVLDIPRVLDMLRQQRMMLVQTLCQYTFVY
 | |.  |. .  |. ..   . | .. .     |  . |..|||| | | ||| .  .| .   |     |.|.  |   ||| |  .. .| .| |.|
swkekttpn.valfvgfvvasrevskkye.....qekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

RV
.|
qv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 966-1163 1.2e-26 88.1 In-house 5-198 (198) alignment 
Range on Protein: 966-1163
Range on HMM: 5-198/198.0
DYIATQGPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRLGSrhNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTG--QERTVWHLQYT
 ||||| ||..|  |||||||| |   | ||  ..         |||   |   |  || . .||.  |    |. | | .    |     | . | |.|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttes..gtgkygslsvttktittkpdytitaliltnnttappstreishyqft

DWPEHGCPEdLKGFLSYLEEIQSVRRHTNstsdpQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHN--EVLDIPRVLDMLRQQRMMLVQTLCQYTFVY
 | |.  |. .  |. ..   . | .. .     |  . |..|||| | | ||| .  .| .   |     |.|.  |   ||| |  .. .| .| |.|
swkekttpn.valfvgfvvasrevskkye.....qekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

RV
.|
qv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 972-1161 2.7e-15 50.6 In-house 98-281 (302) alignment 
Range on Protein: 972-1161
Range on HMM: 98-281/302.0
GPLQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRlgSRHNTVTYGRFKITTR-FR------TDSGCY--ATTGLKMKHLLTGQERTVWHLQY
 | ..|.. .| .. .  .||.. ...  |.. .|   |.       .....||. ..|   .      ||   .   |  .| ..  . ...||  |..
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysd..kvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TDWPEHGCPEDLKGFLSYLEEIQSVRRHtnstsdpqspnppLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVY
. ||.|| |.. .  |  |   .| ..              .|||||||||||| ..     |    ...| |.  ... .|| |   ||.  | ... 
sawpdhGapkeaytaldilkfcesykkn.............vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_hpo-7_pd Subfamily hpo-7 974-1168 2.2e-08 28.3 In-house 43-227 (263) alignment 
Range on Protein: 974-1168
Range on HMM: 43-227/263.0
LQNTCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRlgSRHNTVTYGRFKITTRFRTDsgcyaTTGLKMKHLLT-----GQERTVWHLQYTDWPEH
| .| . |.|..  ..   ..|..  .| |.||  .|.|    . .   .   ...|    .      . || ..||       . .|| | .|. |.|.
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPl..ekdekqklanvnvcttkvqs.....dvllktlellstlgeKkkthtvkhysykgWiek

GCPEDLKGFLSYLeeiqSVRRhtNSTSdpqspnppLLVHCSAGVGRTGVVILSEI----MIACLEHNEV--LDIPRVLDMLRQQRMMLVQTLCQYTFVYR
  ||. .  |  |     | |  || |        | ||||.|.||.    . |.    ||  |.  .   ||  ..|. ||..|   ..|  |  |   
ndpelareilnil....kvar..nsks........lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsil

VLIQFL
....|.
mvLdfv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 977-1168 6.2e-13 43.4 In-house 40-221 (255) alignment 
Range on Protein: 977-1168
Range on HMM: 40-221/255.0
TCQDFWQMVWEQGIAIIAMVTAEEEGGREKSFRYWPRlgSRHNTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLkg
| . |.|..  ..   ..|..  .| |.||  .|.|    . .   .   ..||   .      |  .  .     . .|| | .|. |.|.  ||.   
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfpl..ekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPela..

flsylEEIQSVRRHT-NSTsdpqspnpPLLVHCSAGVGRTGVVILSEI----MIACLEHNEV--LDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFL
     .||. . .   .|         ...||||.|.||.   .| |.    ||  |.  |   ||  ..|. ||..|   ..|  | .|   ......
.....reilnilkvvrdsk........svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv
0048076 (Phosphotyrosine protein) phosphatases II 1019-1166 1.1e-23 79.0 In-house 9-141 (145) alignment 
Range on Protein: 1019-1166
Range on HMM: 9-141/145.0
NTVTYGRFKITTRFRTDSGCYATTGLKMKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHtnstsdpqspNPPLLVHCSAGVGRTGVV
. . .| .  . ....      || | . . |.. ||......|..|| ||.|..|. .|. || |......          . | ||||||||||||..
pglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..........ggpvlVHCsaGvgRtgtl

ILSEIMIAcleHNevLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQ
..  .|.    ..  .... .|...|.||.. |..  |. |.|... .
vaaylmll...lg..vsleealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 1046-1162 4.5e-21 70.5 In-house 38-139 (144) alignment 
Range on Protein: 1046-1162
Range on HMM: 38-139/144.0
MKHLLTGQERTVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVrrhtnstsdpQSPNPPLLVHCSAGVGRTGVVILSEIMIacleHNEvLDIPRVLDMLRQ
 ..  .  ||.........|| ||.|..|. .|. || |...          .... | ||||||||||||....  .|.    ..  |..  .|...|.
eeyepefleregiqylhlpwpDhgvpdllellleflefieea..........leeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrs

QRMMLVQTLCQYTFVYR
.|.. |..  |. |...
rrpgavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1053-1168 2.2e-14 47.6 In-house 87-194 (440) alignment 
Range on Protein: 1053-1168
Range on HMM: 87-194/440.0
QERTVWHLQYTDWPEHGCPEDLKGFlsyLEEIQSVRRhtnstSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQ
. ||. . .|  ||..| |.        |. || |       |. .. | |||||||||.|||||.|  . ..   .... .||  ... .|..|  .||
esrtlkqyhyqgwpdkgvpkfagpv...lkmiqdvne.....sqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvq

TLCQYTFVYRVLIQFL
|  ||.||. .... |
tpeqyafvheavlegl
PTPc_DSPc_SM00012 1056-1165 1.5e-31 104.1 In-house 1-104 (105) alignment 
Range on Protein: 1056-1165
Range on HMM: 1-104/105.0
TVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNStsdpqspNPPLLVHCSAGVGRTGVVILSEIMIACLEHN-EVLDIPRVLDMLRQQRMMLVQTL
|| |..||.||.||.||. . .|..|......... .|       ..|..|||||||||||.... .|..  ||.. . .|| ... .||.||. .|||.
tvkhyhytgwpdhgvPeesdsilellravkknknkses.......skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqte

CQYTFVYRVLI
 || |.||.|.
eqylflyrall
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1056-1167 2.2e-14 48.0 In-house 216-343 (350) alignment 
Range on Protein: 1056-1167
Range on HMM: 216-343/350.0
TVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDP-QSPNPPLLVHCSAGVGRTGVVI-----LS--EIMIACLEHNEVLD--------IPRV
 |..||.  |.. .   . . .|. ||  . .    .. |   ..  .|.||||||||||||...     ||  ||.    .. . ||        |  .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

LDMLRQQRMMLVQTLCQYTFVYRVLIQF
.  ||.||. .||.| |. |.|  |  .
vnelrkqrismvqnldqfifiYeallfy
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1056-1168 1.6e-11 38.1 In-house 219-344 (349) alignment 
Range on Protein: 1056-1168
Range on HMM: 219-344/349.0
TVWHLQYTDWPEHGCPEDLKGFLSYLEEIQSVRRHTNSTSDPQSP-NPPLLVHCSAGVGRTGVVILSEIMIA----CLEHNEVLDIP--------RVLDM
 .. ||. .|.. .   . . .|  ||  . .    ..    ..   ..|||||||| |||||..  .....      ..   ....         ... 
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

LRQQRMMLVQTLCQYTFVYRVLIQFL
||.||. .|| | |. ..|  |....
lrkqrismvqnlaqfiaiyealLkyf
0038934 (Phosphotyrosine protein) phosphatases II 1062-1125 2.8e-06 22.6 In-house 82-139 (194) alignment 
Range on Protein: 1062-1125
Range on HMM: 82-139/194.0
YTDWP--EHGCPEDLKGFLSYLEEIQSVRrhtnstsdPQSPNPPLLVHCSAGVGRTGVVILSEIMI
| ..|  ..|.. .|.  |..|. .. .          ..|.   .||| ||.||||... . .. 
ylklpfpddgtvPsleillrfldlvdefl........nedpggvvaVHCkaGlgRtGtlvaaYLiy
subfamily_CG42327_pd Subfamily CG42327 1091-1169 2.1e-19 64.3 In-house 237-316 (319) alignment 
Range on Protein: 1091-1169
Range on HMM: 237-316/319.0
TNSTSDPQSPNPPLLVHCSAGVGRTGVVILSEIMIACLEHN-EVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
 .| |  .. . || |||| ||||||.|| |.| |  ||.. . .|||...  .|..|   |.|  || |.|.|| .. |
issrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyak
PTEN_1 1104-1161 3e-06 22.2 In-house 133-186 (196) alignment 
Range on Protein: 1104-1161
Range on HMM: 133-186/196.0
LLVHCSAGVGRTGVVILSEIMIACLehnevLDIPRVLDMLRQQR-MMLVQTLCQYTFVY
 |||| ||.||.|.|. .  | .       |.    |...|..|  . ... .|  ...
VlVHCkaGlgRsGtvvaayLmykgk.....ltadeAlelvrekRppgapnspsqerlle
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1105-1169 1.6e-08 28.9 In-house 2-66 (69) alignment 
Range on Protein: 1105-1169
Range on HMM: 2-66/69.0
LVHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLK
.||||.| ||||  |   . .| .  . ..||   .  .|. | |.|    .| |..  |.. ||
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1106-1170 4.9e-08 27.2 In-house 2-66 (69) alignment 
Range on Protein: 1106-1170
Range on HMM: 2-66/69.0
VHCSAGVGRTGVVILSEIMIACLEHNEVLDIPRVLDMLRQQRMMLVQTLCQYTFVYRVLIQFLKS
||||.| ||||  |   . .| .  . ..||   .  .|. | |.|    .| |..  |.. || 
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl