Gene PTPN20 in Homo sapiens

Synonym: CT126, PTPN20A, bA142I17.1, bA42B19.1, hPTPN20, RP11-142I17.1, PTPN20B

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN13
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP078_AA protein Get Run
HsapP078_AA_132-414 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0050432 (Phosphotyrosine protein) phosphatases II 119-417 1.4e-102 338.4 In-house 4-303 (308) alignment 
Range on Protein: 119-417
Range on HMM: 4-303/308.0
VSEGELDQLAQIRPLIFNFHEQTAIKDCLKILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVN
... .|..|..... |....... ..|.||.||...  . ...||..|  .  ..|......| |..||||.||||||..|| |... |||||||... .
ildallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgys

CGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLK-KPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQ
 . .  .||||||| .|..|||.|| |.|..|| |.|...| |..||..||| .|. ..|| ..|.| | ....|.....| .... ...| |. |....
sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfh

FTKWPDHGTPASADSFIKYIRYARKSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKLL
.| |||||.| |...........|||.  ||.|||||||.||||.|...|.... . |.. ... ..|...|||| |||||.|||.|.|...|| |...|
ytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkl
0039614 (Phosphotyrosine protein) phosphatases II 137-417 1.4e-82 272.8 In-house 12-293 (297) alignment 
Range on Protein: 137-417
Range on HMM: 12-293/297.0
FHEQTAIKDCLKILEEKTAAYDIMQEFMALELKNLPgeFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKD------YINASYIRIVNC-GEeyFYIATQ
. ... ..|.|. || ..  . ...||. |   . .  .  .. | |..||||.||||||..|| |   ..      ||||||.   .. .    .||||
ipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltr..kfIatq

GPLLSTIDDFWQMVLENNSNVIAMITREIEGGIiKCYHYWPISLKkplELKHFRVFLENYQILQYFIIRMFQVVEksTGTSHSVKQLQFTKWPDHGTPAS
||| .|..|||.|| |....|| |.|...| |  ||..||| .     . ..|.| | ... |.....| . |.   .| |. |...|.|.|||||.| |
gPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvpps

ADSFIKYIRYARKSH----LTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKLL
...... ....|. .      ||..||||||.||||.|.. . ... . |.. ... ..|...||||.|.||| .||.|.||..|| |.. |
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 143-413 3.7e-67 221.7 In-house 10-283 (319) alignment 
Range on Protein: 143-413
Range on HMM: 10-283/319.0
IKDCLKILEEkTAAYDIMQEFMALELKNLPgEFNSGNQPSNREKNRYRDILPYDSTRVPLG-----KSKDYINASYIRIVNcgEEYFYIATQGPLLSTID
.|. ||.|.. |.   . .||. |.  .   .|.| ... |..||||..||.|| ||| |      .. ||||||.|   .  |.  .||||.||  ||.
Lkerlkalas.tgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyq..erekfiatqaPlentie

DFWQMVLENNSNVIAMITREIEGGIIKCYHYWPIslKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGT-SHSVKQLQFTKWPDHGTPASADS---F
|||.|| |..| .. |.|.  | . .|. .|||   ... |  .. | ||. . |. .||| ... .||.   . .||. |.|.||||. | .| |   .
dfWrmvWeeessivvmltklveklkvklkkywpe..enfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldl

IKYIRYARKSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
.| || .|. .  ||.|||||||.|||| |. .|...  . ..   ..  .| ..| ||  |||..|||.|.|...||..
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleav
subfamily_PTPRK_pd Subfamily PTPRK 143-411 3.4e-63 208.4 In-house 6-275 (314) alignment 
Range on Protein: 143-411
Range on HMM: 6-275/314.0
IKDCLKILE-EKT-AAYDIMQEFMALELKnlpgeFNSGNQPSNREKNRYRDILPYDSTRVPL----GK-SKDYINASYIRIVNcgEEYFYIATQGPLLST
..|.|. .   |.  .| . .|. .|        ... ..  ||||||. |||.|| .|| |    |  | |||||..|   .      .|.||||| .|
vadllqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsyk..rpaafivtqgPlqet

IDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKpleLKHFRVFLENYQILQYFIIRMFQVVE--KSTGTSHSVKQLQFTKWPDHGTPASADSF
. |||..|...|.  | |.|  .| | .||..|||   ..    ....| | . ..|. ...|.|.| .  ..    . |.|.||..||||..| || ..
vkdfWrlvydencasivmltelvevgrvkClkyWPedtev...ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgl

IKYIRYARKS--HLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLE
.|..|   ||  .  |..||||||| ||||.|. .|.|   | ..   ..  .| ..|.... ||.|.|||.|.||..||
lklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
0036941 (Phosphotyrosine protein) phosphatases II 145-417 7.2e-89 293.3 In-house 1-281 (297) alignment 
Range on Protein: 145-417
Range on HMM: 1-281/297.0
DCLKILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSK-DYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMV
|.||.||...  . ...||. |    |.|... .. | |.|||||.||||||.||| |.... |||||||. . ... .  .||||||| .|..|||.||
dllkllekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrk..fIatqgPlpntvedFWrmv

LENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENYQI--LQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYAR
.|.|..|| |.|...| | .||..|||    ..|. ..|.|.| ....  |.....| ..|. . .| |. |.....|.|||||.| |..|....|...|
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvr

K------SHltGPMVVHCSAGIGRTGVFLCVDVVFCAIV---KNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKLL
|      |.  ||..||||||.||.|.|...|.... .    |.. ..| ..| ..|||| |.||| |||.|.|...|| |.| |
kvlkllpsg..gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
subfamily_PTPN3_pd Subfamily PTPN3 145-414 2.3e-79 261.2 In-house 3-276 (280) alignment 
Range on Protein: 145-414
Range on HMM: 3-276/280.0
DCLKILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSK-DYINASYIRIVNCGEEYF--YIATQGPLLSTIDDFWQ
. |  |.|  .. .....|  |  |.   . .  ..| | .|||||||||||.||| | .|. |||||.|. .   ...    |||||||| .|  ||||
esllllkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWq

MVLENNSNVIAMITREIEGGIIKCYHYWPIsLKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYAR
|| |..|..| |.|  .| | .||..|||   .. ||. .|.| .|. .  . ...| . . .|.|  .... |||.. ||||| | ....|.....  |
mvweqksslivmlttlverGrvkChqyWPe.tedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervr

KSH--LTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR
| .   . |.|||||||||||||.. ... .. | .. .....||| .||.||. .|||..||.|  . .|.| .
klrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvye
subfamily_PTPN14_pd Subfamily PTPN14 146-414 1.2e-67 223.1 In-house 12-297 (300) alignment 
Range on Protein: 146-414
Range on HMM: 12-297/300.0
CLKILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKS----KDYINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQ
  ||||.|     . .|.  .  |.. ....... | | ||||..|.|||. .|| |  .    ..||||| |... .|.|..||..||||  |. ||||
rakilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWq

MVLENNSNVIAMITREIEGGIIKCYHYWPIS--LKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYI--
|| |.. ..|.|.|.|.|.|  |...|.| .   || .| ..|.|  .  .  . .| . ...    ..   .|  ||.| ||||| |   ..|..|.  
mvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLee

----RYARKSHL-----TGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR
    |.. .|.        |..||||||.||||| . .|..  .. .| . .|  ..|..||||  .|||  ||.| |..... |.
vqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
0047943 (Phosphotyrosine protein) phosphatases II 148-413 2.3e-86 285.0 In-house 3-272 (273) alignment 
Range on Protein: 148-413
Range on HMM: 3-272/273.0
KILEEKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPL-GKSKDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLEN
..||...  . ...|| .|     ..... .. | |..||||.||||||..|| | ... |||||||..  |.. .  .||||||| .|..|||.|| |.
lllekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrk..fiatqgPlpntvedfwrmvweq

NSNVIAMITREIEGGIIKCYHYWPISLKK-PLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHL
|..|| |.|...| | .||..||| .  . .|. ..|.| | .... .....| .... ..|| |. |.....|.|||||.|.| .|....|...|| . 
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

----TGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
     ||.|||||||.||||.|...|.... . |.  ... ..|...|.|| ||||| ||| |.|...|| |
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN6_pd Subfamily PTPN6 150-412 5.5e-74 243.9 In-house 19-296 (306) alignment 
Range on Protein: 150-412
Range on HMM: 19-296/306.0
LEEKTAAYDIMQEFMALELKNLPGE--FNSGNQPSNREKNRYRDILPYDSTRVPL----GKSKDYINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMV
 ||...  ....|| .|. ..       . |..|.|.|||||. |||.| ||| |     . .|||||.||.    |..  |||||| | .|. |||.||
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmv

LENNSNVIAMITREIEGGIIKCYHYWPISLKKPLeLKHFRVFLENYQILQYFIIRMFQVV-EKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRY---
...||.|| |.|.|.| |  ||..||| . .|.    . .|   . . |...|.| ..|  .|. .....| |..|..|||||.|.. . ......    
wqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnr

ARKSHL---TGPMVVHCSAGIGRTGVFLCVDVVFCAIVK---NCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV
 ...     .||.|||||||||||| |. .|..   | |   .. ..| ..| ..||||||.|||..||.| | .. . 
kqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 150-410 1.2e-58 193.2 In-house 3-274 (287) alignment 
Range on Protein: 150-410
Range on HMM: 3-274/287.0
LEEKTAAYDIMQEFMALE--LKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGK----SKDYINASYIRIVNcgEEYFYIATQGPLLSTIDDFWQMV
.||. .  |. .|. ||    .  .  | . ..  . .|||| |.||.| ||| | .      ||||| |.   .  ..  .||.|||. .|. |||..|
veerrvkddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasyt..ddeafiaaqgPiaatvrdfwrav

LENNSNVIAMITREIEGGIIKCYHYWPISlKKPLELKHFRVFLENYQILQ-YFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYI-----
||..| .....|||.| .  |||.|||   ..|. .  . | | .|.|..  . .| .....  |  .. ||||.. .|||.. . .| ..|...     
letrsasvitmtreveearlkcykywPer.evPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkq

--RYARKSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVL
    ||..  .||.|||...||||.|..| . |.     .    ..  .|...||.| ..||.  |. . |. . 
hielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
0045450 (Phosphotyrosine protein) phosphatases II 151-414 4.3e-81 268.3 In-house 21-305 (307) alignment 
Range on Protein: 151-414
Range on HMM: 21-305/307.0
EEKTAAYDIMQEFMALELK---NlPGEFNSGNQPSNREKNRYRDILPYDSTRVPLG------KSKDYINASYIRI------VNCGEEYFYIATQGPLLST
. ..  . . .||  |        .||..... | |..||||.||||||.||| |       .. |||||||.|.        .     .||||||| .|
llldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpet

IDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISlKKPLELKHFRVFLENYQILQYFIIRMFQVVEK-STGTSHSVKQLQFTKWPDHGTPASADSFI
..|||.|. |....|| |.|...| | .||..||| . . .|. ..|.| | ....|.....| . |  .  || |. |.....|.|||||.| | ....
vedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeell

KYIRYARKSH----LTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCS---FNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR
. |...|| .      ||..||||||.||||.|.. ... . . |..    ... ..|...||||.|.||. |||.|.|...|| |.
dfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll
0045098 (Phosphotyrosine protein) phosphatases II 152-415 9.6e-82 269.8 In-house 2-274 (278) alignment 
Range on Protein: 152-415
Range on HMM: 2-274/278.0
EKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPlgkskDYINASYIRIVncgeEYFYIATQGPLLSTIDDFWQMVLENNSNVI
|..| .|...||  | | . |.|.. .. ..|..||||.||||||..||      ||||||||..        .||||||| ||..|||.|. |....||
ealasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk.....dYINAsyidgy....pkkfIatqgPlpstvadfwrmlwelgitvi

AMITREIEGGIIKCYHYWPiSlKKPLELKHFRVFLENYQILQYFIIRMFQVVEK----STGTSHSVKQLQFTKWPDHGTPASA--DSFIKYIRYARKSH-
 |.|...|.| .||..||| . ...|. ..|.| |.....|.....|.. |.      ....|. |..|... |||||.| .   .||...... |. . 
vmltelvelgrekcaqywp.e.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealk

--------------LTGPMVVHCSAGIGRTGVFLCVDVVFCAIvkNCSFNIMDIVAQMREQRSG-MVQTKEQYHFCYDIVLEVLRK
                ||..||||||.||||.. ... . . .  .. ... ..|...|.|| | .||..|||.|.|. .||.|..
llaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 152-413 1.4e-69 229.6 In-house 15-283 (305) alignment 
Range on Protein: 152-413
Range on HMM: 15-283/305.0
EKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKS-----KDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLEN
|...  |   |    .| ...  .. |..  |..|||...| ..|  |. | ..     .|||||||.   .  ..  ||..|||| .|..|||....| 
earvysdkgleaqykslyeeeesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkk..yivaqgPlkntvadfWrlivee

NSNVIAMITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENYQILQYFIIRMFQVVE-KSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHL
  ..| |.|. .|||  ||. ||| | ... |. .| | |.. .  . .|.| ...   ..   |..| |.|.|.||||| | .| |... |.  .|.. 
kvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqk

TG---PMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
 .   |..||||||.||||||..||. .  . |  . ...... |.|..| .||||..|| |..|.. | .
kdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldeli
subfamily_Ptp69D_pd Subfamily Ptp69D 152-412 5.3e-60 198.1 In-house 17-285 (307) alignment 
Range on Protein: 152-412
Range on HMM: 17-285/307.0
EKTAAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGK-----SKDYINASYIRIVNcgEEYFYIATQGPLLSTIDDFWQMVLEN
.. . . ...|.  || .. . . . ...  |  |||| || ..|.||| | |     . ||||||.|.  .  |.  .|| |.|. .||.|||.|. | 
krdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgyk..ekkkfiaaqdPveatigDfWRmiaeq

NSNVIAMITREIEGGIIKCYHYWPISlkKPLELKHFRVFLENYQILQYFIIRMFQVVEKS-----TGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYA-
....| |.. . |    || .||||   .  .  .  | | . .  ...||| ..| .|         |. | | ..| |.|   | .| . .|.|. . 
evtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvr

-RKSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV
  ...  .|.||||||| ||.|.|...|...  . .. . .|...| ..|.||. .||  ||| |.|  .|. 
elyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
0040438 (Phosphotyrosine protein) phosphatases II 153-416 2.9e-86 284.9 In-house 15-279 (317) alignment 
Range on Protein: 153-416
Range on HMM: 15-279/317.0
KTAaYDIMQEFMALELKNLPgEFNSGNQPSNREKNRYRDILPYDSTRVPLGK-----SKDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENN
. . . ...||. |   .|. ... .. | |..||||.||||||..|| |       . |||||||. . |.. .  .||||||| .|..|||.|| |..
sdf.talleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrk..fIatqgPlpntvedFwrmvweqg

SNVIAMITREIEGGIIKCYHYWPIslKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKS--HL
..|| |.|.. | | .||..|||   ...|. ..|.| | ... |.....| ..|. . ...|. |.....| |||||.| | |.... ....|..  . 
vtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedp

TGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKL
 ||..||||||.||||.|........ . |.. ... ..|...||||.|.||| |||.|.||..|| |.. 
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
subfamily_PTPRD_pd Subfamily PTPRD 154-414 3.9e-87 288.2 In-house 20-282 (564) alignment 
Range on Protein: 154-414
Range on HMM: 20-282/564.0
TAAYDIMQEFMALELKnLPGEFNSGNQPSNREKNRYRDILPYDSTRVPL-----GKSKDYINASYIRIVNcgEEYFYIATQGPLLSTIDDFWQMVLENNS
.  .....|.  .| .    .... |.| |..|||| .|..||..|| |      .. ||||||.|   .  ..  |||||||| .||.|||.|| |.||
nsdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr..krkayIAtqgPlaetiedFWRmvweqns

NVIAMITREIEGGIIKCYHYWPISlKkPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSH--LT
..| |.|.  | |  || .||| . . . .  .. | ||. . |....|| |.. .|..  |. |.| .||.||||| | || |... ||  |...   .
stiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepda

GPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR
||.|||||||.||||.|. .|..   | ..   .|. .|...|.||  ||||.|||.|.....|| | 
gPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
0051299 (Phosphotyrosine protein) phosphatases II 155-413 3.8e-90 297.5 In-house 21-286 (288) alignment 
Range on Protein: 155-413
Range on HMM: 21-286/288.0
AAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLG-----KSKDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSN
  . ...|| .|  .. ........ | |.|||||.||||||..|| |       . ||||||||.. |.. .  .||||||| .|..|||.|| |.|..
gltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk..fIatqgPlpntvedFWrmvweqnvr

VIAMITREIEGGIIKCYHYWPIslKKPLELKHFRVFLENYQILQYFIIRMFQVVEK----STGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKS--
|| |.|...| | .||..|||   ...|......| | ....|.....| ..|. .     .|.|. |.....|.|||||.| |........|..||.  
vIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

HLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
.  ||.|||||||.||||.|...|.... . |.  ......|...|||| ||||| ||| |.|...|| |
sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 155-414 2.2e-76 252.0 In-house 18-281 (318) alignment 
Range on Protein: 155-414
Range on HMM: 18-281/318.0
AAYDIMQEFMAL-ELKNLPGEFNSgNQPSNREKNRYRDILPYDSTRVPLGK-----SKDYINASYIRIVNcgEEYFYIATQGPLLSTIDDFWQMVLENNS
    . .|. .|   .. . ...| ..| |. |||| .||.||.||| | .     . |||||.||   .  ..  |||.|.||  ||.|||.|| | ||
Gelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyr..rkkayiaaqaPlpetieDfWrmvWeqns

NVIAMITREIEGGIIKCYHYWPIslKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSH---L
 || |.|.| | | .|. .|||   |.. .... .| |..   |.....| |.| .. .  |  |.| ..|.|||.|.|.|. |... .| ..| .    
avivmltqeeergkakvhryWPs..kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksg

TGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR
.||.|||||||.||||||. ||..   | ..   .....| |.||||  ||||..||.|.||..|| | 
agpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_PTPRB_pd Subfamily PTPRB 155-415 1.3e-75 249.1 In-house 23-287 (293) alignment 
Range on Protein: 155-415
Range on HMM: 23-287/293.0
AAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPL-----GKSKDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSN
. . ...|.  |.. .   . .. ... ||.||||..||||| .|| |      ...|||||.||.  |.  |  .||||||| .|.||||.||.|..|.
sdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynspre..fiatqGPlpetvddfWrmvwekkss

VIAMITREIEGGIIKCYHYWPISlKKPLELKHFRVFLENYQILQYFIIRMFQVVEksTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKS----HL
.| |.|. .|.| .|| .|||   ..|    . .| | . . |. ..|| ... .  . ....|.|..|| ||||| | .........|  |..    . 
iivmltqlvekgkvkCeeYWPad.eepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektas

TGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRK
..|.|||||||.||||.|...| .. || ..   .|. |||..||.|  .|||..|| | .. ||..|||
krPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_ptpA1_pd Subfamily ptpA1 155-369 2e-32 107.5 In-house 19-251 (418) alignment 
Range on Protein: 155-369
Range on HMM: 19-251/418.0
AAYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSK-----DYINASYIRivnCGEEYFYIATQGPLLSTIDDFWQMVLENNSN
. . | .||  ||    | | . |..  |  |||| .||| . ||| | | .     ||||| ||          .|.|||||  || |||.|| ||   
cihkikeefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyid...gaypkqfictqgplpntiadfwrmvwenrcr

VIAMITREIEGGIIKCYHYWPISLKKplelKHFRVFLENYQILQYFIIRMFQVVE-------------KSTGTSHSVKQLQFTKWPDHGTPASADSFIKY
.| |..|| |   ||| .|||  .      ..| .. .  ...  . . . .|..                | .. . | |.  ||||  |  .. | . 
iivmlsresencrikcdrywpeqigg....eqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrql

IRYA--------RKSHLTGPMVVHCSAGIGRTGVFlCVDVV
..            |    |..||||||.|||| | |  |.
lhsitnrqnqiipssdrnvpiivhcsagvgrtgtf.ctavi
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 156-413 4.4e-74 244.1 In-house 20-279 (288) alignment 
Range on Protein: 156-413
Range on HMM: 20-279/288.0
AYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGK-----SKDYINASYIRIVncGEEYFYIATQGPLLSTIDDFWQMVLENNSNV
  .. .|. .|   .   . . |... | .|||||.||||| .|| | |     ..||||||||     ...  |||||||| .|..|||..| ||... 
rtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge..kkkkkyiatqgPladtvndfWelvyenktst

IAMITREIEGGIIKCYHYWPISlKKPLELKHFRVFLENYQILQYFIIRMFQVVekSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHL--TGP
|.|.|  .|||  || .||| . .|| .  .. | | . . |. |. | . ..   ..|   ..|.|.. ||||| |.|.  .....|    ..   |||
ivmltelveggktkCeeYWPda.dkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgp

MVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
..||||||.||||.|. .| .  |. ..   .....||..|.||  .|||..|| |.|...|.. 
iivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPN9_pd Subfamily PTPN9 156-413 3.1e-64 211.8 In-house 15-290 (297) alignment 
Range on Protein: 156-413
Range on HMM: 15-290/297.0
AYDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKS-----KDYINASYIRIVNcgEEYFYIATQGPLLSTIDDFWQMVLENNSNV
   ...|....  ..  |.|.  ....| ||||| |.| ||.||| | |       |||||...   .  ..  .|||||||  |..|||.|| |..  |
krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGyk..qkkafiatqGplkktvsdfWrmvWeqevlv

IAMITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARK--------
| |.|| .| | .|| .||| . ..  |  ...|   . .  . . .|.... .  |. | .|   ||. |||.|.| || |... .. .|.        
ivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavke

------SHLTG-PMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
       |..| |.|||||||||||| |  .|.    . .    .... | ..|.||. ..|| |||.|||  |||  
lgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 157-414 2.4e-61 202.2 In-house 20-279 (287) alignment 
Range on Protein: 157-414
Range on HMM: 20-279/287.0
YDIMQEFMALEL-KNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPL-GKSKDYINASYIRivNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMI
 . .. |. ||  .. . |   .  ..|..|||...||..|  ||.| |. .|||||..|      |.. .|....|. .|. .||... ..| ..| |.
egfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllkgehpdyinavfid..gykekkafiiaesPmfntarnfWkliddrnvtaivml

TREIEGGIIKCYHYWPISLKkpLELKHFRVFLENYQILQYFIIRMFQVVEKS-TGTSHSVKQLQFTKWPDHG-TPASADSFI---KYIRYARKShLTGPM
..| |    .||.||| .    . | .... | | .. . .|.| ..| .|. .|. ..||| |.|.|...|  .  . ...   . ..  ||.   ...
cqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkr.gntsi

VVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR
|||||...||...|. ...      ..   ...... ..| |. |.||| |||.| .||||| | 
vvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 157-415 4.8e-37 122.3 In-house 22-289 (305) alignment 
Range on Protein: 157-415
Range on HMM: 22-289/305.0
YDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGK--SKDYINASYIRIVNcgEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMI
  . .||.|..  |    ...  .  ...||||.|.   |  || |     ..|| | |.      .   .| || ||  |  ||| | |... . | |.
aglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvstpt..npkrfictqaplektcadfwymclqdkveaifml

TREIEGGIIKCYHYWPISLKKPLELK----HFRVFLENYQILQY------FIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSH
   .| |  ||..|..   |. ||..    .  | .|  . |..       . .   |.| . .... |..  .  ||| | ||.  . .. .  || |.
cnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk

ltGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIM-DIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRK
  ||.||||||||||||  . .. ..  ..     .    |. ..||||   .|| .|| | ....|. .||
..gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 157-411 2.1e-34 113.5 In-house 11-267 (281) alignment 
Range on Protein: 157-411
Range on HMM: 11-267/281.0
YDIMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGK------SKDYINASYIRIVNCgeEYFYIATQGPLLSTIDDFWQMVLENNSNV
 |. |||  |            ||| | .|||| .|   | .|| |        | ||| | |||      .  || ||||   |  |||.|. ..|.  
ddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspfl..krgyiltqgpkketradfwrmiwqentta

IAMITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENYQILQYFIIRMFQVVekSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKShlTGPMV
| |. . .|    ||  |.|   .  |.. .. |  |.  . . ..   ...     | .. . .  . .|||   | |.. ..| .|  |    . | |
ivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnls..yegetrlithwlwkewpdwqvpessevmlkilrkirar..stppv

VHCSAGIGRTGVFLCVDVVFCAIVKNCSF-NIMDIVAQMRE-QRSGMVQTKEQYHFCYDIVLE
.|||||.||.| ...|.. . .|    .. .| .||...|   |.  ||| .|| . . ..|.
ihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
0043336 (Phosphotyrosine protein) phosphatases II 158-412 1.3e-79 262.8 In-house 21-276 (278) alignment 
Range on Protein: 158-412
Range on HMM: 21-276/278.0
DIMQEFMALELKNLpGEFNSGNQPSNREKNRYRDILPYDSTRVPLGK-----SKDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIA
 ...||  |   .| .... .. | |..||||.||||||..|| |       . |||||||.   |....  .||||||| .|..|||.|| |.....| 
llllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprk..fiatqgPlpetvedFwrmvwelgvttiv

MITREIEGGIIKCYHYWPislKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKS--HLTGPMV
|.|.. | | .||..|||   ...|. ..|.| | ... |.....| . |. . .| |. | ......|||||.| | ..........|.   .  ||..
mLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngpvl

VHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV
||||||.||||.|........ . |.. ... ..|...|||| |.||| .||.|.|...|| 
VHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 158-417 1.9e-61 202.6 In-house 6-272 (274) alignment 
Range on Protein: 158-417
Range on HMM: 6-272/274.0
DIMQEFMALELKNlpgEFNSGNQPSNREKNRYRDILPYDSTRVPLG----KS--KDYINASYIRIVNcGEEYFYIATQGPLLSTIDDFWQMVLENNSNVI
|. .||. | |     . .  . . . .||||..||| . .|| |     ..   .|||| ||.  . .|.  |.|||||| .|..|||.|. .....||
dlekeflelPlnf...dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGyd.eeskayvatqGPlpntvadfWrmiyqeevqvi

AMITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENYQILQY--FIIRMFQVVEKSTgtSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKS-----H
 |.|.  |    || .|.| . .  .. ..  | ... .|..   . .| . . . .   ..|||   .|.|||| .| .|..... ..  ..|     .
vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeena

LTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKLL
 ..|.||||||||||||.|. ...    . ..   ... ||...| .| |||||.|||.. . .. . |..||
klapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrll
0046845 (Phosphotyrosine protein) phosphatases II 159-417 2e-89 295.1 In-house 2-278 (284) alignment 
Range on Protein: 159-417
Range on HMM: 2-278/284.0
IMQEFMALELKNLPG--EFNSGNQPSNREKNRYRDILPYDSTRVPLG------KSKDYINASYIRIVNC---GEEYFYIATQGPLLSTIDDFWQMVLENN
...||..|   . .   ... .. | |..||||.||||||..|| |       .. |||||||..  ..     .  .||||||| .|..|||.||.|.|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

SNVIAMITREIEGGIIKCYHYWPISlKKPLELKHFRVFLENYQILQYFIIRMFQVVEKS-TGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKS---
..|| |.|...| | .||..||| . ...|....|.| | .... .....|..... .. || |. |.....|.|||||.|.|........|..|..   
vrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-HLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNC---SFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKLL
 .  ||.|||||||.||||.|...|.... . |.     ... ..|...|||| ||||| ||| |.|...|| |...|
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkl
DSPc_SM00195 159-413 1.5e-86 285.3 In-house 2-262 (263) alignment 
Range on Protein: 159-413
Range on HMM: 2-262/263.0
IMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKS-----KDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIAM
. .||  || .. | |........|..||||..|||||.||| | |.     .|||||.||.. |. ..  |||||||| ||..|||.||.|.....|.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkk..yIatQgPlpstvedFWrmvweekvkiivm

ITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENYQILQ-YFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHL--TGPMV
.|.| | | .||..||| . ... . ....| | .... .  .|.| ... .. . ....|.|.|...|||||.| |..|.....|...||.   .||.|
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
||||||.||||.|...|..   . ..  ..| .|| ..|.|| |||||.|||.|.|...||..
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 159-413 1.5e-86 285.3 In-house 2-262 (263) alignment 
Range on Protein: 159-413
Range on HMM: 2-262/263.0
IMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKS-----KDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIAM
. .||  || .. | |........|..||||..|||||.||| | |.     .|||||.||.. |. ..  |||||||| ||..|||.||.|.....|.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkk..yIatQgPlpstvedFWrmvweekvkiivm

ITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENYQILQ-YFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHL--TGPMV
.|.| | | .||..||| . ... . ....| | .... .  .|.| ... .. . ....|.|.|...|||||.| |..|.....|...||.   .||.|
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
||||||.||||.|...|..   . ..  ..| .|| ..|.|| |||||.|||.|.|...||..
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 159-417 2e-71 235.4 In-house 17-280 (281) alignment 
Range on Protein: 159-417
Range on HMM: 17-280/281.0
IMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPL-----GKSKDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIAM
 ..|. .|.  ..    .. ... |..||||..|  || ||| .      |. |||||...  ..  .|  |||||||. .....|||||.|.. ..|.|
fieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgeke..yiatqgPvPaslvafWqmvweqkvsaivm

ITREIEGGIIKCYHYWPiSLKKPLELKHFRVFLENYQILQYFIIRMFQVvEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYA---RKSHLTGPMV
.|||||.| .||..|||   .. |.. ...|  .. .  . .| | |.. |...| . .|.||..|.||||| ||..  .... .     ....   |.|
vtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplv

VHCSAGIGRTGVFLCVDVVFCAIVKN-CSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKLL
.|||||.||||... .| .. |. ..  . .. ..||..|..|  ||||  ||.| | .||..| | |
ihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 159-415 1.6e-62 206.0 In-house 22-285 (290) alignment 
Range on Protein: 159-415
Range on HMM: 22-285/290.0
IMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLG---KSKD----YINASYIRivNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVI
  ..|..|.  . . . . |. .||...||...|..||  |..|    . ||    ||||.||   .  |.. |||||||. .|. |||... .... .|
frnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik..gykekkqyiatqgpvsntlvdFWkliwqekvtii

AMITREIEGGIIKCYHYWPISlKKPLeLKHFRVFLENYQILQYFIIRMFQVVEKST-GTSHSVKQLQFTKWPDHG----TPASADSFIKYIRYARKSHlT
 |.| .|| |  ||. ||| | .    . .|.. | | ..|...|.| ..| .|.. |...||.|.|.| |...|    . ..  .. . ..  ||.   
vmltniieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg.n

GPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRK
...|||||...||..||. ...      ..   ...... ..| |. |.|||..||.. ..|||. | .
tsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_PTPRA_pd Subfamily PTPRA 159-412 1e-61 203.6 In-house 34-294 (330) alignment 
Range on Protein: 159-412
Range on HMM: 34-294/330.0
IMQEFMALELKNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGK-----SKDYINASYIRIVNcgEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAM
. .|| ||   .. . ..  ..  |.||||. .||||| .|| | .     . ||||||.|   .  |   .||.|||.  |..|||.|. | .|  | |
freefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGyk..ekdkfiaaqGPkeetvedfwrmiweqksativm

ITREIEGGIIKCYHYWPISlkKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGT----SHSVKQLQFTKWPDHGTPASADSFIKYIRYARKS--HLTG
.|   |    ||. |||      .   . || .|. ..|. . .| | | ... .|    |  |.|. || ||| | |. .   .|...  .|     .|
ltelkerkeekcaqywPde..GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag

PMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV
|.|||||||.|||| |. .| |.  .  .   .. ..| ..| ||. ||||.|||.|.| ..|| 
pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 159-412 2e-39 130.4 In-house 18-276 (307) alignment 
Range on Protein: 159-412
Range on HMM: 18-276/307.0
IMQEFMALELKNlPGEFNSGNQPSNREKNRYRDILPYDSTRVPL---GKSKDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIAMIT
...||  |  |. |   .     .| .||||.|.   | .|. .   | . ||| | |. |        .|..|||| .|. .|| |..... . . |. 
lvdefrvlakkt.pegvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikpkk..ficaqgplentqysfwamaiqekvesvimlc

REIEGGIIKCYHYWPISLKKP--LELKHFRVFLENYQILQY----FIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKShlTGPM
. || . |||  |||.   .      .   . ..|  . .      .| . ..  . .. | ....||...|||.|.|    . |  .   |    | |.
kvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd..tnpv

VVHCSAGIGRTGVFLCVDVVFCAIVK--NCSfNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV
|||||||.||.|  ... .|   ...  ||  .. ..| ..|.||   .||. || . . ..|| 
vvhcsaGvGrsGtivaislvqdkmiaGinck.dmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_PTPRG_pd Subfamily PTPRG 161-414 4e-63 208.5 In-house 23-288 (563) alignment 
Range on Protein: 161-414
Range on HMM: 23-288/563.0
QEFMALELKNLPG--EFNSGNQPSNREKNRYRDILPYDSTRVPL----GKSK--DYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIA
.|| ||. .  .   . .. ..|.|..|||| .|..||..|| |    || |  |||||.||   . ...  .||||||| .|.||||.|. |.|...| 
eefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkska..fiatqgplkdtfddFWrmiWeqnvaiiv

MITREIEGGIIKCYHYWPIslKKPLELKHFRVFLENYQILQYFIIRMFQVVE-----KST-GTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLT
|||   | |  ||  |||    .........| |.. ..| .  .| ... .     |.   | . |.| ..|||||||.| ..   ..... . ... .
mitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka

--GPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR
  ||.|||||||.||||... .| .   | .. . |. ... ..| ||  .|||.||| | .|..||...
eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 161-411 9e-49 160.9 In-house 13-264 (283) alignment 
Range on Protein: 161-411
Range on HMM: 13-264/283.0
QEFMALELKNLPGEFNSGNQpsNREKNRYRDILPYDSTRVPLG-KSKDYINASYIRIVNC-GEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREI
. .  | . .|. . .| ..  |..|||...|.|.|  || |  .|.|||||..| . .   ..  ||..|.||  |. |||.|| ...   | |.|.  
evlkrlsvpdldadiasade..nkrknrnqeivpadqwrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklq

EGGIIKCYHYWPIslKKPLELKHFRVFLENYQILQYFIIRMFQVVEK-STGTSHSVKQLQFTKWPDHGTPASADSFIKY--IRYARKSHLTGPMVVHCSA
|.  |||  |||   .   .   | | |..    . |||. . .  . |. ..  .   |.  | . |  |  .|..|.  ..  .. .  ||.|||||.
edlrikCsqyWPk..rGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCst

GIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLE
|||||.||. . .    .  .   ... .|  ||||| ..|||..|| . ...|||
giGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_CG42327_pd Subfamily CG42327 167-343 9.2e-20 65.5 In-house 10-193 (319) alignment 
Range on Protein: 167-343
Range on HMM: 10-193/319.0
ELKNLPGEFNSGN--QPSNREKNRYRDILPYDSTRVPLG-----KSKDYINASYIRIVNCGEEYfYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIE
|...||    . .   .. ..|.|. ...|   ||| |      ... |..|||.|  .  . . |||.| .| ..  |||..| |..| ||  .|   |
efrdlPqliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapns.yiaaqvsledsssdfwrtvweqqsrvivqltdlse

GGIIKCYHYWPISLKKPLE--LKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFtKWPDHGTPASADSFIKYIRYARKS
 || .| .|.| .   . .    ...| | . .. . ..|  . . .     |  .    . ||.. . ||.  ..|  .  .|.|
lGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_PTPRN_pd Subfamily PTPRN 169-417 3.6e-50 165.3 In-house 42-296 (297) alignment 
Range on Protein: 169-417
Range on HMM: 42-296/297.0
KNLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGK-----SKDYINASYIRIVNCgEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGII
.. |   . .... | .|||....|||| .|| | .     ..|||||| |   .   .  |||||||| ||. |||||| |. . || ..||  | |. 
eaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdp.rapayiatqgplastvadfwqmvweqGvvvivnltrleeegvk

KCYHYWPISLKKPLELkhFRVFLENYQI-LQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHL--TGPMVVHCSAGIGRT
.|..|||   ..  ..  . | |    |  . ...| | . .  |  . .| |. |  ||..|.|||| |.... |   ||.   . |.|||||.| |||
qckrywpdeGsevyhi..yevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrt

GVFLCVDVVFCAIVKNC-SFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKLL
||.. .|.|   ..|     .|.  .  .|.||.|.|.||.|..|..  | | ....|
GvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnail
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 170-412 1.1e-51 171.0 In-house 35-287 (325) alignment 
Range on Protein: 170-412
Range on HMM: 35-287/325.0
NLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGK-----SKDYINASYIRIVNcGEEyFYIATQGPLLSTIDDFWQMVLENNSNVIaMITREIEGGIIK
. .  ..   .| |..|||.......| .|| |       | |||||||.|    . .  ..|.| || .||.|.|..||. .. |. ... |...|  .
ddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddk.kkd.vflaaqaPltatindlWrlvldWrcsvv.vvlneldlgkdr

CYHYWPISLKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARK--------SHLTGPMVVHCSAG
|  |||  . |  ..  ..| |   . .  .. |...| . . | . ||||.|.  |.| |..    ..| ...   .        .. ..|..||||||
cavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaG

IGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV
.||||||...  .   .... . .|.. | ..|..|  ||.| .|| ..|. . |.
vGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealvea
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 170-336 5.2e-37 122.3 In-house 20-189 (297) alignment 
Range on Protein: 170-336
Range on HMM: 20-189/297.0
NLPGEFNSGNQPSNREKNRYRDILPYDSTRVPLGK---SKDYINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCY
. ...| | ...|   |||||||| .|.||| | .    .||||| |.   .  ... || .|||| .|.||||..| |.. .||.|...  |.|  ||.
argesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkca

HYWPISLKKPLELKHFRV-FLENYQI-LQYFIIRMFQVVEKstGTSHSVKQLQFTKWPDHGTPASADSFIKY
 ||| . .. |.  .. | || ..    .  |.  .|.. .    |  |.  ||  ||||| |.  .   ..
pywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrf
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 172-411 7.3e-18 59.2 In-house 36-277 (303) alignment 
Range on Protein: 172-411
Range on HMM: 36-277/303.0
PGEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSkDYINASYIRIVNcgeEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPI
| .    .  .| .|||. |..  | ..| |  |  || |||. .     .   | || ||  |  |||||..|.. ... ..  . |   .     .| 
ppsvsknqfvknmdknrfvdvicldhskvklsds.syihasylelds...skkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfpr

SlKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQL-QFTKWPDHGTPAS-ADSFIKYI----RYARKSHLTGPMVVHCSAGIGRTGVFLC
  .  |....  . . ... ..      ..|.  | |. .|  .. .. .||    |.  .  |.| |     . ||   . | |    .| ||.| |  
n.qdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfal

VDVVFCAIV-KNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLE
 .    ..  .. |....  . ..|. |   ||   |. . | .. |
fetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_PTPN13_pd Subfamily PTPN13 173-416 9.9e-94 308.6 In-house 27-272 (273) alignment 
Range on Protein: 173-416
Range on HMM: 27-272/273.0
GEFNSGNQPSNREKNRYRDILPYDSTRVPLGKSKDYINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPIS
 . ..|.. .|..|||||..|||| |||.||..  |||||.|..    .|| |||.||||  |..|||||| | ...||||.| | |.| .||  ||| |
dtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPes

LKKPLELKH-FRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHL-TGPMVVHCSAGIGRTGVFLCVDVVF
 .|.| ..  ..| |...| |. | .| ..| .. .| |. | .|.|.||||||.|.||......... |. .  .||.||||||||||.|.....|||.
knkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqtdagPivvhcsaGiGrsGtlitidvvl

CAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKL
  | .. .|.. .|| ..|||| |.||||.|| |.| ..||||..|
glierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlksl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 173-414 3.9e-67 221.6 In-house 46-291 (298) alignment 
Range on Protein: 173-414
Range on HMM: 46-291/298.0
GEFNSGNQPSNREKNRYRDILPYDSTRVPLGK-----SKDYINASYIRivNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYH
 | . ...|.|..|||| ||...||.|| | |       ||||||..   .  ..  .||||.|| .|. |||.|| |.....| |.|   | . .|. .
eekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh..aykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhk

YWPIslKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSH-LTG--PMVVHCSAGIGRTGVFL
|||   ..  .  ...| | . .    .|.| ..| .|.. ....|.||.||.|||.|.|. | | ....|  |.|.  .|  |..|.||||.||.| | 
ywPd..egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfi

CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR
 .| |.  . |. .  ....|  .|..| |.|||.||| |.|..|||.| 
aidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 173-411 5.1e-54 178.7 In-house 51-289 (319) alignment 
Range on Protein: 173-411
Range on HMM: 51-289/319.0
GEFNSGNQPSNREKNRYRDILPYDSTRVPLGK-----SKDYINASYIRIVNCgeEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITreieggIIKCYH
 . .  | . |..|||. .||..| ..| | .       ||||||..       .  |||.||||  |..|||.|. | |.  | ..|        ||  
adqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqr..kdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsq

YWPISLKkpLELKHFRVFLENYQILQYFIIRMFQVVEKSTG-TSHSVKQLQFTKWPDHGTPASADSFIKYIRY----ARKSHLTGPMVVHCSAGIGRTGV
|||   .   . ..| | ..  .  . ...| ... |..      ...|  |  |||.| | ..  ... ..      .| .   ..|||||||.|||||
ywplkiv..ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGv

FLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLE
.. .||..  . ..   .. ..| ..|.||. .||   ||.|.|  .||
yivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_CG7180_pd Subfamily CG7180 173-412 9.7e-45 147.5 In-house 32-289 (296) alignment 
Range on Protein: 173-412
Range on HMM: 32-289/296.0
GEFNSGNQPSNREKNRYRDILPYDSTRVPLGK-----SKDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIiKCYH
|.   | .  ||||||. ...||| .|| | |     ..|||||.|.      .|  || |..|  .|.|.||..| ..... . ..|.. .    ..  
gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkke..yivteapkketvdefWrlvydeeisavvvLtktfdfak.myps

YWPISLkkPLELKHFRVFLENYQILQYFIIRMFQVVEK--STG--------TSHSVKQLQFTKWPD-HGTPASADSFIKYIRYARK---S----HLTGPM
|||       . ... | . ... .  . ||.|... |  ...            ||..|.|.|.  .  | |. ..|. .| .|.          .||.
ywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPv

VVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV
||..| | .|.||.| .|.    . |.  ... . | ..|..| ..|...|.|...||..|| 
vvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 173-230 7.9e-08 26.4 In-house 38-95 (95) alignment 
Range on Protein: 173-230
Range on HMM: 38-95/95.0
GEFNSGNQPSNREKNRYRDILPYDSTRVPLGK--SKDYINASYIRIVncGEEYFYIATQG
  .  |   .|  |||. .|.|||.||| |      ||||| ..          |||.||
apytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgy..arkncyiaaqg
0040439 (Phosphotyrosine protein) phosphatases II 174-413 4.4e-76 251.0 In-house 2-246 (249) alignment 
Range on Protein: 174-413
Range on HMM: 2-246/249.0
EFNSGNQPSNREKNRYRDILPYDSTRVPLGK-----SKDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHY
|.. .. | |..||||.||||||..|| |.        ||||||||   ... .  .||||||| .|..|||.|. |....|| |.|.. | | .||..|
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrr..fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPIslKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSH----LTGPMVVHCSAGIGRTGVFL
||   ...|| ..|.| | ..........|..... . .|.|. |...|.|.|||||.| | ......|...|| .      ||..||||||.||||.|.
wpl..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
. . ... . |.. ... ..|...|.||.|.||. ||| |.|...|| |
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 175-414 5.1e-65 214.4 In-house 36-278 (315) alignment 
Range on Protein: 175-414
Range on HMM: 36-278/315.0
FNSGNQPSNREKNRYRDILPYDSTRVPL-----GKSKDYINASYIRIVNCGEeyFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYW
 ... .. | .||||..|||.||.|| |        .||||||||. |.. .   |||.|||| ...||||.|||...   |.|.|   ||  |||  ||
qrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddk..ayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqyw

PISLKKPLELKHFRVFLENYQILQYFIIRMFqvVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSH--LTGPMVVHCSAGIGRTGVFLCVD
|    .  |.  ..| | . .     ..| .  | . . .|. | | |||.|||.|..  . |..|.|.  . ..   . ...||||||.|||||.. .|
PdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisid

VVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR
 |   | .. | .....| ..|..|  .|||.|.| | ||.||| | 
evvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 175-411 1.8e-53 176.9 In-house 17-253 (284) alignment 
Range on Protein: 175-411
Range on HMM: 17-253/284.0
FNSGNQPSNREKNRYRDILPYDSTRVPLGK-----SKDYINASYIRIVNCgeEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITreieggIIKCYHYW
 .  | . |..|||. .||..| ..| | .       ||||||.|       .  ||||||||  |..|||.|. | |.  | ..|        ||  ||
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqr..kdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqyw

PISLKkpLELKHFRVFLENYQILQYFIIRMFQVVEKSTGT-SHSVKQLQFTKWPDHGTPASADSFIKYIRY----ARKSHLTGPMVVHCSAGIGRTGVFL
|   .   . ..|.| ..  .  . ...| ... |..  .   ...|  |  |||.| | ..  ... ..      .| .   ..|||||||.|||||..
plkiv..ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyi

CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLE
..||..  . ..   .....| ..|.||. .||   ||.|.|  .||
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 175-413 3.7e-51 168.8 In-house 37-236 (392) alignment 
Range on Protein: 175-413
Range on HMM: 37-236/392.0
FNSGNQPSNREKNRYRDILPYDSTRVPL-----GKSKDYINASYIRIVNCgeEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGiikcyhyw
 ...... | .||||..||||||.|| |        .||.|||||. ...  |  |||.|||  ...||||.||...|   |||.|.  ||         
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdn..ekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd........

pislkkplelkhfrvflenyqilqyfiirmfqvvekSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKS--HLTGPMVVHCSAGIGRTGVFLCVD
                                         ..| | .||.|||.. |  . |..|.|.  .    . | |...|||||.||||| ...|
....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisid

VVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
 | .   |    .....|...|..|  |||||||| | |  ||| |
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
0049772 (Phosphotyrosine protein) phosphatases II 175-416 5.7e-41 136.6 In-house 38-283 (314) alignment 
Range on Protein: 175-416
Range on HMM: 38-283/314.0
FNSGNQPSNREKNRYRDILPYDsTRVPLGK----SKDYINASYIRIVncgeeYFYIATQGPLLSTIDDF----------WQMVL--ENNSNVIAM-----
.  .... ||.|||| ||||.| .|| |..    . |||||||.. .       .|||||||  |..||          |.|||  ..|. .| |     
ilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdev

----------------ITREIEGGiikcyhywpiSLKKPLELKHFRvflenyqiL-----QYFiirmfqvvekstgtSHSVKQLQFTKWPDHGTPaSADS
                ...  ..|          ..  . .|....              ..|              .. . ..  . .||...| . . 
ladelsrLdaAlgKtpllildgng..........neptaadlellk........eelydpelf..............erlgikylripvpDgsap.lled

FIKYIRYARKSHLTGPMVVHCSAGIGRTGVFLCVDVvfcaIVKNCSFNIMDIVAQMREQRS-----GMVQTKEQYHFCYDIVLEVLRKL
| . ... .. .  || .|||.||.||||.|....     ..| . ... ......|..|.     |.... ||| |.....|| |..|
fdeflefieeadkggpvlvHCkaGkgRtgtfvvaay....lmkllgvsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 175-334 2.2e-15 50.9 In-house 88-242 (244) alignment 
Range on Protein: 175-334
Range on HMM: 88-242/244.0
FNSGNQPSNREKNRYRDILPYDSTRVPLGKS---KDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIAMItreieGGIIKCYHYWPI
..   .|.|  |||    ||.|  |||| |.   . |||||..  .    |  || || ||  |  |||.|.||   ||. ..     | . .   ||| 
mkdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrtae..yiltqhpladtsmdfwkmmlerhvnvlvvl.....gsveeedeywpd

SlkKPLELK--HFRVFLENYQILQYFIIRMFQvVEKSTGTSHS-VKQLQFTKWPDHGTPAsADSFI
|  .|||       | | . . ..      .. .|     ||  .  .| ..||  ||    | ||
s..eplewyeeditvtltdrdefknikasnle.iesdmneshqaltmfqisnwpsdgttp.ndhfi
0042113 (Phosphotyrosine protein) phosphatases II 176-413 3.5e-74 244.6 In-house 2-243 (245) alignment 
Range on Protein: 176-413
Range on HMM: 2-243/245.0
NSGNQPSNREKNRYRDILPYDSTRVPLGKSK-----DYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWP
.... | |..||||.||||||.||| |   .     |||||||.   .. .   .||||||| .|..|||.|. |.....| |.|.| | | .||..|||
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpk..fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

IslKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARK---SHLTGPMVVHCSAGIGRTGVFLCVD
   . .|. ..|.| | ....|.....| ..|. . .. |. | ..... |||||.| . ..... ....||   ..  ||..||||||.||||.|....
l..gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaay

VVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
 ... . |.. ... ..|...|.||.|.||| .||.|.|...|| |
lmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 176-418 5.1e-74 243.8 In-house 33-282 (290) alignment 
Range on Protein: 176-418
Range on HMM: 33-282/290.0
NSGNQPSNREKNRYRDILPYDSTRVPLGKS-----KDYINASYIRIVNcgEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWP
..|....|..||||.|||||| .|| | |      .|||||..|. |.  ..  |||.||||  |.||||.|. | | ... |. ||.| | .|| .|||
eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgve..gkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

ISLKKPLELKHFRVFLENYQILQ-YFIIRMFQVVEKstGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHL--TGPMVVHCSAGIGRTGVFLCVD
 . ...||  .|.| ||. . ..  |.||...|  .  ..|..|.|...|.|||||.|.||.| .. |. .|. .     |.|||||||.||||. . .|
eegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGtiiaid

VVFCAIVKNCS---FNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKLLT
 |  .. ..     ... |.|...|.||. .|||||||.. |  |.|...| |.
yvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
0037934 (Phosphotyrosine protein) phosphatases II 176-411 1.9e-72 239.0 In-house 3-240 (243) alignment 
Range on Protein: 176-411
Range on HMM: 3-240/243.0
NSGNQPSNREKNRYRDILPYDSTRVPLgKSKDYINASYIRIVNcgeeyFYIATQGPLLSTIDD----FWQMVLENNSNVIAMITREIEGGIIKCYHYWPi
. .. | |..||||.|||||| .|| | .. |||||..|....      .||||||| .|..|    ||.|. |....|| |.|...| | .||..||| 
siallpenlsknrysdilpydhsrvkl.egsdyinanliyvtp.....rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywp.

slKKPlELKHFRVFLENYQILQYFIIRMFQVVEKS-TGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYAR----------KSHLTGPMVVHCSAGIGRT
   .  . ..|.| | ... |.....|..... .. .. .. | ..... |||||.| | ..........|          . .  ||..||||||.|||
..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRt

GVFLCVDVVFCAIvkncSFNIMDIVAQMREQRSG-MVQTKEQYHFCYDIVLE
|.... ...   .    .... ..|...||||.| .||| .||.|.|...||
Gtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPN1_pd Subfamily PTPN1 176-415 5.9e-65 213.9 In-house 25-273 (290) alignment 
Range on Protein: 176-415
Range on HMM: 25-273/290.0
NSGNQPSNREKNRYRDILPYDSTRVPLGK-SKDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLK
.. ..|.||..|||||. ||| .|. | . ..|||||| . . .   .  || ||||| .|.| ||||| |..|  . |. . .| . |||..|||   .
reaklpenrnlnryrdvspydhsrikleradndyinaslveleeakrs..yiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgee

-KPLELK--HFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSH----LTGPMVVHCSAGIGRTGVFLCVD
 | |.|.  ...| | . .. .|...|.... ...|  .... .  .|.||| | | |  .|.|..   |.|       || |.||||||||.| |  ||
ekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGtfclvd

VVFCAIVKNCS---FNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRK
 ..  | |.      .| . . ..|..| |..||..| .| |  .||  ..
tclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 177-414 1.7e-60 199.3 In-house 3-243 (250) alignment 
Range on Protein: 177-414
Range on HMM: 3-243/250.0
SGNQPSNREKNRYRDILPYDSTRVPLGKSK-----DYINASYIRIVNcgEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIkCYHYWPI
 ...|.|.||||| ||...||.|| | |.|     ||||||..   .  |.  .||||||| .|| |||.||||..|..| |.|   | .   . .|||.
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyd..erkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPv

slKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLT---GPMVVHCSAGIGRTGVFLCVDV
  .|. .  . .| | . ..   ...| ... ...   .  |.||.|. ||| | |. | . .....  ..|.     .|..|.||||.||.| |. .| 
..ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida

VFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR
|.  . |.   ...... ..|..| ..|...||| |.| |.|. | 
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 178-413 8.1e-43 141.2 In-house 35-293 (301) alignment 
Range on Protein: 178-413
Range on HMM: 35-293/301.0
GNQPSNREKNRYRDILPYDSTRVPLGKS-------KDYINASYIRivNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWP
| . .|.. ||...| .||  |. | .        ..|||||||   .. |.  .||.|||. .|. |||......    | |.| . ||   ||..|||
glseenkalnrfknitvyddnriilkpkpnldlcqreyinasyid..gysekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywp

ISLKKPLELKHFRVFLENYQILQYFIIRMFQVVE---------------KSTGTSHSVKQLQFTKWPDHGT---PASADSFIKYIRYARKSHLTGPMVVH
 | ..  |  .| | | | |..  |.|| ..|.                ||. .|..| ||| |.||..|    |.     |  . .....   ||.|||
nseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqkigggpvvVH

CSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
||....|.||.  |..       ..  ......  .| .. |.|.| ||| . ||.. . |
CSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 178-217 2.8e-06 20.9 In-house 42-86 (440) alignment 
Range on Protein: 178-217
Range on HMM: 42-86/440.0
GNQPSNREKNRYRDILPYDSTRVPLGK-----SKDYINASYIRIV
 . |.|. |||||.|| || .|| | .     ..||||||||  .
aslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_egg_pd Subfamily egg 179-416 3.1e-22 73.6 In-house 36-273 (307) alignment 
Range on Protein: 179-416
Range on HMM: 36-273/307.0
NQPSNREKNRYRDILPYDSTRVPLGK-----SKDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGgiIKCYHYWPISL
 .  |.|| | . .   ||.|| |       . |.| | ...     .|  .| .| ||  | ||||.|| ... . | |.|   |    .| .||| . 
asdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllne..filaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae

KKPLELKHFRVFLENYQILQYfIIRMFQVVE-KSTGTSHSVKQLQFTKWpDHGTPASADSFIKYIRYARKshLTGPMVVHCSAGIGRTGVFLCVDVVFCA
...| .    . .||... .     .|.| . |  |. .  . |.  .. |    .   | .. .| .|.  |. |.||..  |. .......... .. 
sdslvtvpGslrienlkvdsk.adplfrvtklklvGgddeerflehwqg.dvnnssdvysplrvlrklrn..lskpvvvqdilGvskaatlvaieialls

IVKNC--SFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKL
...     . ..  |  .| .|   |..  .| | | .|| ..| .
llrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdv
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 180-413 5.5e-60 198.0 In-house 45-284 (297) alignment 
Range on Protein: 180-413
Range on HMM: 45-284/297.0
QPS---NREKNRYRDILPYDSTRVPLG---KS--KDYINASYIRIVNCgeeyFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIiKCYHYWPI
.     | ||.||..|||||| || |    ..   ||.|||... ..      .|.|| |  .|..|||.|||... ..|.|.. . |.   || .||. 
vaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh....rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsd

SLKKPleLKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPA--SADSFIKYIRYARKSHLT---GPMVVHCSAGIGRTGVFLCV
.  ..  . .  | |.  .  . || | ..| . .. . . ||| ||..|||.  .   || |..|.|   ||.. .   ||..|||.||.|||||.| .
kgvtt..fGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllti

DVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
| | . . .. . .|...| ..|..|  .|||||||.| | .|||.|
dsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 180-412 6e-51 168.2 In-house 46-278 (315) alignment 
Range on Protein: 180-412
Range on HMM: 46-278/315.0
QPSNREKNRYRDILPYDSTRVPL-----GKSKDYINASYIRIVNCGEeyFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISlk
.  |..|||| .|..|| .|| |      .  ||.||..|   |  .   |||.|||. ....|||..| |..   | |.|  .||   |. .|||    
kienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkr..ryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..

kPLELKHFRVFLENYQILQYFIIRMFQVVEKSTgtSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHL--TGPMVVHCSAGIGRTGVFLCVDVVFCA
  .   .. | . . .. . . .| . || ..    . | ||..| ||| | |... .....|| ... |    |..|||||||.|||| |...| |.  
.kviyGkitvtrkseevnteytvrtlsvvfgdn..irevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldq

IVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV
.  .   .. ... ..|..| .|||. |||.| ||..|| 
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 180-412 5.2e-40 132.0 In-house 51-288 (305) alignment 
Range on Protein: 180-412
Range on HMM: 51-288/305.0
QP-SNREKNRYRDILPYDSTRVPLGKS--KDYINASYIRIVNCGEEYFyIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKP
 .  .  ||||.|.   | . | | |    ||| | |.      |  | |..||||  |||.|| ||..|. . | |. . .| | .|| .|||..  . 
sadiaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipekrf.icaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

LELKHFRVfLENYQIL------QYFIIRMFQVvEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLtgPMVVHCSAGIGRTGVFLCVDVVF
||||   | .||              | ....   | . . ||..||.|.||| | |    . .. .   | |..  |.||||||||||||  .... ..
lelksgiv.venvsgskpmerdaeiqitllnl.tysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv..pivvhcsagigrtgtivaieyil

CAIVKNCSFN-IMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV
  | .| .   . ..|  .|.||.  .|.  || | . ..|. 
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 181-414 3.7e-65 215.0 In-house 41-277 (515) alignment 
Range on Protein: 181-414
Range on HMM: 41-277/515.0
PSNREKNRYRDILPYDSTRVPL-----GKSKDYINASYIRIVNCGEeyFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKK
  | .||||..||||||.|| |        .||.|||||. ...     |||.|||. ...||||..||..|   |||.|.  ||  ||| .|||    .
einfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndk..ayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgd

PLELKHFRVFLENYQILQYFIIRMFQVVEKSTgtSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKS--HLTGPMVVHCSAGIGRTGVFLCVDVVFCAI
 ... ...| |   .     |.| ..|.  .   |. | | .||.|||.|.|  . |..|.|.  . .  ..| |...|||||.|||||.. .| |   .
svkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisidsvvaha

VKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR
 .  . .....| ..|..|  .|||.||| | |..||| | 
kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 181-412 3e-38 126.4 In-house 33-269 (285) alignment 
Range on Protein: 181-412
Range on HMM: 33-269/285.0
PSNREKNRYRDILPYDSTRVPLG-KSKDYINASYIRIVNcGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLEL
 .| . ||| |.   . ||| |  . .||| ||..|.    ..  ||.|||||  |. |||.|. ...   . |.   .|||. ||  |.|  | . ...
eanpdlnryadvrcieetrvvlknhdrdyihaswmrmpg.kdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkf

KHFRVFLENY--QILQYFIIRMFQVVEKSTGTSHS--VKQLQFTKWPDHGTPASADSFIKYIRYARKSH-LTGPMVVHCSAGIGRTGVFLCVDVVFCAIV
 .. . | .   . .   |.  . |..    .|    ....|   |||. .|  |  .|.  .. .|      |..||||||.|||  |. .|     |.
gkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvgidyatirim

KNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV
.|   ...||| .||  |   ||.. |. | | ...| 
enpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 182-413 4e-57 188.2 In-house 19-264 (270) alignment 
Range on Protein: 182-413
Range on HMM: 19-264/270.0
SNREKNRYRDILPYDSTRVPLGKS-----KDYINASYIRIVNCGEEYfYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKP
 ... |||.||||   ||| | .        |||| |.| ..  ... |||..||| .|. .||.|..|.... |.|.|   | |  ||  ||| . |. 
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkk.YiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkek

--LELKHFRVFLENYQILQYFIIRMFQVVekSTGTSHSVKQLQFTKWPDHGTPASAD------SFIKYIRYARK---SHLT-GPMVVHCSAGIGRTGVFL
  ||  . .|. .. .  . .|..  ..   ..|... .   ....||||| | ..|      . .| .|  |.   ..   .|..||||||.||||...
vkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtli

CVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
 .| ..... .. . ... |....|..|  .||. |||.| |  |.|  
alDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 182-411 3.3e-50 165.5 In-house 2-237 (237) alignment 
Range on Protein: 182-411
Range on HMM: 2-237/237.0
SNREKNRYRDILPYDSTRVPL---GKSKDYINASYIRIVNcGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPiSLKKPLE
 |. |||| .|  || .|| |   | . |||||.|.. .. |    |||.|||| |. ||||||| ...  || |.|  |||  .||..||| | ..|  
enkiknrygnivaydhsrvvlkgagsgsdyinatylkgfd.gtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaa

LKHFRVFLENYQILQYFIIRMFQVVEKSTGTS-HSVKQLQFTKWPDHGTPASADSFIKYIRY--ARKSH--LTGPMVVHCSAGIGRTGVFLCVDVVFCAI
   . | |   . .  . .| . .... |      ..| ||| |||.| |  . ..... .    |  |   .|| ..|||||.||||.|| .| ..   
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

VKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLE
 ..   .| . |  . |.|  ..|||.|| | .. .||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 182-411 5.7e-49 161.4 In-house 6-238 (239) alignment 
Range on Protein: 182-411
Range on HMM: 6-238/239.0
SNREKNRYRDILPYDSTRVPLGKS-----KDYINASYIRIVNcGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKP
 |. |||| .|. || .|| | |       |||||||.|  . |    |||||| .  .  |||.|. ..   || |.|  |||   ||..||| |  | 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdyd.gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

LELkhfRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTG--PMVVHCSAGIGRTGVFLCVDVVFCAIV
 .|   || | . ...  .||| | . .      . | | .|| |||.| |  | . .   |   |  | |  | |.|||||.|||| || .| ..    
cnl...rvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

KNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLE
|. . .|.. |  .||.|  |||| ||| | .  |||
kqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 182-411 7e-49 161.1 In-house 7-239 (239) alignment 
Range on Protein: 182-411
Range on HMM: 7-239/239.0
SNREKNRYRDILPYDSTRVPLGKS-----KDYINASYIRIVNcGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKP
 |. |||| .|. || .|| | |       |||||||.|  . |    |||||| .  .  |||.|. ..   || |.|  |||   ||..||| |  | 
vnkaknryanivtydhsrvvleklsndphsdyinasylrdyd.gspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstsky

LELkhfRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHLTG--PMVVHCSAGIGRTGVFLCVDVVFCAIV
 .|   || | . ...  .||| | . .      . | | .|| |||.| |  | . .   |   |  | |  | |.|||||.|||| || .| ..    
cnl...rvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

KNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLE
|. . .|.. |  .||.|  |||| ||| | .  |||
kqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 182-412 4.1e-45 148.7 In-house 53-282 (290) alignment 
Range on Protein: 182-412
Range on HMM: 53-282/290.0
SN--REKNRYRDILPYDSTRVPL--GKSKDYINASYIRivncGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPL
 |   .||||.|.   | ||| |  |   ||. | |..    | .  .| |||.| .|. |.|.|||...  .| |.   || |  || .|.|    . |
kntefkknrykdvvcndktrvilkdGydGdyvhanyvk....GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevl

ELKHFRVFLENY-QILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKshLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKN
 . .. |   .  .  .  | ... | .| .| .| .| |.   |||.  . |. .... .|  ||  ..||.|||||||||||| |  ..|    ... 
tfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk..asGpvvvhcsaGiGrtGtfvaievglqilldG

CSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV
 .....|.|  .|. | . ||   ||    .|.|..
keldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 182-411 3.4e-36 119.6 In-house 32-257 (267) alignment 
Range on Protein: 182-411
Range on HMM: 32-257/267.0
SNREKNRYRDILPYDSTRVPLG-KSKDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKcyhYWPIS---LKKPL
 |.|.||. | |||| |||.|  | ..||||||.   . ..   .|.||.||  || ||.... ...  || ..|.  .. | .   .||      ||  
knqernrlddnlpyddtrvilrtkeeeyinasyvegyktkna..fivtqdplkntitdfltvihdqkvpvivlltkvftdnirl...fwPPkmgqakkyq

ELKHfRVFLENYQiLQYFIIRMfQVVEKsTGTSHSVKQLQFTKWPDHGTPA-SADSFIKYIRYARKSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKN
.|      ||. .  .| || . ..  |   ..| |    . ||            ..  .   .      |.||.||.|.||.| || .|  .  . ..
dltv.ehslekee.ndyqiitl.elkfk.nesahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerakte

CSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLE
   .| | . ..|.|| |.|.|||.| ...... |
gvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 182-415 2.2e-23 77.1 In-house 50-287 (302) alignment 
Range on Protein: 182-415
Range on HMM: 50-287/302.0
SNREKNRYRDILPYDSTRVPLG-KSKDYINASYIRIVNCGeeYFYIATQGPLLSTI---DDFWQMVLENNSNVIAMITREIEGGIiKCYHYWPISLKKPL
.| .||.  |.  .||..| |. . ..|.||| . . ...  .  | .| | ...    ..||.|| ...   . .. .| |       ...|    . .
knlkknqsedvpildsnlvkleaepdsyvnaskvevPelt..rsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdyk

ELKHFRVFLENYQILQYFI-IRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIR--YARKSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAIV
| ....|     .  .      .  |. .    |  ..   .| |...  | .  . || .   .|.|.. . ..|.    |.|| |.|| . |... . 
eygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavaveklq

KNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRK
|.   || .||...|.||. .|.. .|| . | ..|  ..|
kgkepnikeivksiRsqRpravdslkQyvslyialllyikk
Y_phosphatase Protein-tyrosine phosphatase 183-411 6.1e-78 256.8 Pfam-A 1-235 (235) alignment 
Range on Protein: 183-411
Range on HMM: 1-235/235.0
NREKNRYRDILPYDSTRVPL---GKSKDYINASYIRIVNcGeEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLEL
|..||||.||||||.||| |   ....|||||.|..  .   .  .||||||| |||.|||.||......||.|.|.. | |  || .||| . ...|. 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

KHFRVFLE-NYQ-ILQYFIIRMFQVVEKSTGT-SHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSH--LTGPMVVHCSAGIGRTGVFLCVDVVFCAIV
....| |. . . . . ...| ... .| . . ...||||..|.|||||.|.|..|....||  .||.   .||.|||||||.||||.|...|.... . 
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

KNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLE
.. ......|| ..|.|| ||||. ||| |.|...||
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 183-411 6.1e-78 256.8 In-house 1-235 (235) alignment 
Range on Protein: 183-411
Range on HMM: 1-235/235.0
NREKNRYRDILPYDSTRVPL---GKSKDYINASYIRIVNcGeEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLEL
|..||||.||||||.||| |   ....|||||.|..  .   .  .||||||| |||.|||.||......||.|.|.. | |  || .||| . ...|. 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.e.kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

KHFRVFLE-NYQ-ILQYFIIRMFQVVEKSTGT-SHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSH--LTGPMVVHCSAGIGRTGVFLCVDVVFCAIV
....| |. . . . . ...| ... .| . . ...||||..|.|||||.|.|..|....||  .||.   .||.|||||||.||||.|...|.... . 
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqle

KNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLE
.. ......|| ..|.|| ||||. ||| |.|...||
aeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPN23_pd Subfamily PTPN23 183-417 1.7e-67 222.3 In-house 43-284 (288) alignment 
Range on Protein: 183-417
Range on HMM: 43-284/288.0
NREKNRYRDILPYDSTRVPLGKSK-DYINASYIRIVNCGEEYFyIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH
. ||||.|||||||..|| | .|| ||||||... .  |   | ||||.|| ||. |||.|| |. |.|| |.. . | |  |. .||| .  .. . ..
yseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgcPdf.iatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgd

FRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARK------SHLTGPMVVHCSAGIGRTGVFLCVDVVFCAI-V
..| |.. . ..... |....  ... . .||. ||.|.||..| ||| .......  ...       ..  |.|||||||.|||||| .|  .  .. .
lsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelek

KNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKLL
.|   .|...| ..||||  |||.|||..|.|..|||  |. |
gnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
0041856 (Phosphotyrosine protein) phosphatases II 183-414 1.3e-48 160.3 In-house 1-172 (182) alignment 
Range on Protein: 183-414
Range on HMM: 1-172/182.0
NREKNRYRDILPYDSTRvplgkSKDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIAMITreieggiikCYHYWPislkkplelkhf
|..||||.|||||| .|       |||||....    . .  .||||||||||. ||..|. |.. ..| ..|         ...|||            
nldknrysdilpydhsr.....dldyInanlylgslpatr..fiatqgpllstvadflrmlkelgittivnlt.........eelywp............

rvflenyqilqyfiirmfqvveksTGTSHSVKQLQFTKWPDHGTPAsADSFIKYIRYARKshLTGPMVVHCSAGIGRTGVFLCVDvvfcaIVKNCSFNIM
                        .   . . |.... |||||.|   |.....|. ...    || .||||||.||||.. . .     ..| ..... 
........................ellerlgiqylylpwpDhgvpd.ldelldfieevle..eggpvlVHCsaGvgRtgtlvaay.....lmkklgvsle

DIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR
..|...|..|.|||.| .|| |.....||.|.
eavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 183-413 3.1e-41 136.2 In-house 48-279 (439) alignment 
Range on Protein: 183-413
Range on HMM: 48-279/439.0
NREKNRYRDILPYDSTRVPL-----GKSKDYINASYIRIVNcgEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITReieggIIKCYHYWPISLKKPL
.. ||||.|. ..| ||| |          |||| ||.     .. .|||||||   | ||||..|.|...  | |.|      ... |.||| . .   
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy..ddklyiatqgpkkettddfwrlviekktvtivmltn.....lvesykywpsdaevcy

elKHFRVFLENYQILQYFIIRMFQVVEKSTGT--SHSVKQLQFTKWPDHGTPASADSFI---KYIRYARKSHLTGPMVVHCSAGIGRTGVFLCVDVVFCA
      |  .    |  ..|| |.|...   |   ..| |.... |||.  || |   .   . |  |  .. .||.|||||||.||||  ...|. .  
..gdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeq

IVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
.  .   .|  ||  .|.||  |||.  || | |. ||| .
lklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 183-413 2e-32 107.4 In-house 43-271 (288) alignment 
Range on Protein: 183-413
Range on HMM: 43-271/288.0
NREKNRYRDILPYDSTRVPLGKSKDYINASYIriVNCGEE-YFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKH
|  ..||...   | ||| |    |.  |. .  | ...     | .| || .||. .|.|.||.. . | |... .| |  |  .|.|  | .   ...
nptrdryenlprcditrvklsddpdfyiaanv..vssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarigr

FR-VFLENYQILQYfIIRMFQVVEKSTG-TSHSVKQLQFTKWPDHGTPASADSFIKYIRYArkSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSF
.  |  .... ..  ....  .  . .| ..  ||.| . .|.|.| | .  |... .       |. |.|||.|||.|||| .  . ..  ..  .   
lctvvkkkradidk.lvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..kslqkPivvhssaGvGrtgtlililialeslrlddfl

NIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
 |  ..|..||.|   .||. || . . .||| |
girsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 183-406 2.3e-26 87.1 In-house 52-283 (310) alignment 
Range on Protein: 183-406
Range on HMM: 52-283/310.0
NREKNRYRDILPYDSTRVPLG--K--SKDYINASYIRIVNCgEEyFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPiSLKK---
.  |||| |..  |..|| |   |   .||| | |..      .  .| .||||  || |||.|.... .. | .. .  | |  ||  ||| ||     
ymhknrysdvvcldtsrvklkidksryedyihanyvktnyl.rs.tficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp.slgvtet

--PLELKHFRVFLENYQILQY---FIIRMFQVVEKSTGT-SHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHltGPMVVHCSAGIGRTGVFLCVDVV
   . .  .    |...| .    |.     | |. .      |. ... .||| | |      .     |.  |  || |||||||..|..| . ... 
ygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrllaqvrh..gpcvvhcsagkdrlyvvvalklk

FCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCY
.  . .    .. ....... .|   .||. || .  
idkldrglkvdaeevktellksraiciqtelqyliid
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 184-273 7.6e-10 32.8 In-house 38-135 (347) alignment 
Range on Protein: 184-273
Range on HMM: 38-135/347.0
REKNRYRDILPYDSTRV----------PLGKSKDYINASYIRIVNCGEEYfyIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISL
 .||| .|    |.|||          .  ... |||||.|.. |. .||  | || || .|. |||.||   .   .  |   |.   |. ..  ..||
lsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskey..iltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaieefanatlsl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 185-404 3.6e-36 119.4 In-house 52-272 (301) alignment 
Range on Protein: 185-404
Range on HMM: 52-272/301.0
EKNRYRDILPYDSTRVPLGK--SKDYINASYIRIVncGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKHF
.|.||  .    || | . .   .  | | .|     |.   .||||||| .| .||| |.   . . |.|.....|  . || .| |.. .. |... |
dkhryptvPckPstavevivdGkrvPihanwipts..GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrf

RVFLENY-QILQYFIIRMFQVVEKSTG--TSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHltGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSF
.. ..|  .||.  |..    || |||  ....|   |...|.|.|.| |     . .  ..||.   |.||||||||||.  |.  ...  ..  .   
kikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse..kPivvhcsaGiGrsvafigteylareveadpti

NIMDIVAQMREQRSGMVQTKEQYHF
.. . ....||.|   |||..| ..
eltealkhlrehrwngvqtnsqlyw
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 185-413 8.9e-34 111.6 In-house 45-276 (312) alignment 
Range on Protein: 185-413
Range on HMM: 45-276/312.0
EKNRYRDILPYDSTRVPL-GKSKDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPiSLKKPLELKHFR
. ||| .|  .|  |  | |  . || | ...|.   |   ...||||| .|.  |||..|   |  | ...  .| |  || .|    .   ..|.  |
dlnrypniqcwdrgrftlagdenfyihanfvkictkper..fvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyis.divgfvdledhr

VFLENYQIL-------QYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSHltGPMVVHCSAGIGRTGVFLCVDVVFCAIVKN
|. |    .       .    |...|| |.||    ... |.. ||||| | | |.  . .   .| .   |.. |||||.|||| .  .. . .|. . 
vyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk..kpviahcsagvgrtgtlaliesmiaalrhp

CSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
   |. |.   .| .|.  |..  || ..  .|||.|
rkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 185-270 5.2e-27 89.5 In-house 49-151 (350) alignment 
Range on Protein: 185-270
Range on HMM: 49-151/350.0
EKNRYRDILPYDSTRVPLG-------------KSKDYINASYIRIV----NCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYH
 ||||..||||. .|| |              ...|||||.|...     .   .. |||||.|| ||.|||....|.|. .|| ..| ..| .. |||.
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWP
||.
YWq
subfamily_eak_pd Subfamily eak 185-332 2.7e-15 50.6 In-house 54-200 (332) alignment 
Range on Protein: 185-332
Range on HMM: 54-200/332.0
EKNrYRDILPYDSTRVPLGKSK----DYINASYIRIVNCGEEYfyIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELK
..|   .|.|||   | |  |.     ||||| .   . |..|  | |  .  . .  |||||||..|  | ..  ..| .. |   |.|   .. |.  
nrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrky..iltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfG

HFRVFLENYQILQYFIIRMFQVvEKsTGTSHSVKQLQFTKWPDHGTPASADS
.. |   ..   . .  |.... .|    .| |.  ..  | .  .|   | 
ildverkefvkrniletrllel.sk.GnethrvlhykvfGwtettlpkyedf
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 193-327 7.1e-11 36.5 In-house 3-127 (130) alignment 
Range on Protein: 193-327
Range on HMM: 3-127/130.0
LPYDSTRVPlgkSKDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIAMItreieGGIIKCYHYWPISlkKPLELKHFRVFLENYQI-
|... .|..    ..|||||.. ...   |  |. || ||  |  |||.|.||   ||. ..     | . .   ||| |  .|||    .. .   .  
lefevsrlq...gntyinasfvGllgrtae..ylltqhpladtsmdfwkmmleryvnvlvvl.....gsveeedeywpds..ePlewyeediivtltdrd

-LQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTP
  ..     ... ..   . ...  .| ..||  || 
efknikasnleiesdlneshqaltmfqisnwpsdgtt
0044763 (Phosphotyrosine protein) phosphatases II 194-411 1.6e-31 104.7 In-house 1-169 (178) alignment 
Range on Protein: 194-411
Range on HMM: 1-169/178.0
PYDSTRVPLGKSK-----DYINASYIRivncgeEYFYIATQGPllstiDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKkplelkhfrvflen
|.| ||| | .       ||||||.|       ...|.....|      |..... |.. ..| ..| |.|.| .||..||| .                
pldrtrvllsnleglersdyinaseil......pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag..............

yqilqyfiirmfqvvekstgtshsvKQLQFTKWPDHGTPASADSFIKYIRYARKS--HLTGPMVVHCSAGIGRTGVFLCVDVVFCAivkncSFNIMDIVA
                          | ... .||||.| . . | . ... ..      || .||||||.||.|.. . . . .      .... ....
.........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

QMREQRSgMVQTKEQYHFCYDIVLE
..||.|. .|.. .|....|.. |.
lvrerRp.ivpnpgqlrqLyefelr
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 197-411 8.9e-21 69.3 In-house 32-258 (290) alignment 
Range on Protein: 197-411
Range on HMM: 32-258/290.0
STRVPLGKSKDYINASYIR--IVNCGEEYFYIATQGPLL-------STIDDFWQMVLENNSNVIAMITREIEGGI----IKCYHYWPISLKKPLELKHFR
 |||.|   .  .|  ||    | | .    |.|| |.        ||| .|| |. . ... . |.    |         | .| | |  . | .| . 
atrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkglt

VFLENYQILQYFIIRMFqVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKShlTGPMVVHCSAGIGRTGVFLCVDVVFCAIV-KNCSFNIM
|   .    . ...|   ||.   .  . |.  ..  | .  .. .  .... |.. ..|  . |..|||  || |  ..  ... .  |. .. |... 
vkCkskekeddvetRel.vvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvkas..ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkle

DIVAQMREQRSGMVQTKEQYHFC-YDIVLE
|.. ..|.||  ........ |  . ||| 
dvlkalrkqralaitsalelafvdagivll
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 203-270 3.9e-16 53.3 In-house 87-154 (349) alignment 
Range on Protein: 203-270
Range on HMM: 87-154/349.0
GKSKDYINASYIRIVNCGEEYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWP
|| .||||| |... .   |  ||||| || ||.|||....| |. ...  .. . | .. ||. || 
gklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
0046846 (Phosphotyrosine protein) phosphatases II 204-414 1.2e-41 137.7 In-house 10-174 (176) alignment 
Range on Protein: 204-414
Range on HMM: 10-174/176.0
KSKDYINASYIRIvncgeeYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLelkhfrvflenyqilqyfiirmfqvv
 . |||||..|        ...||||||| .|. ||..|..|.. ... ..| |.| | .||..|||.  |  .                          
ldldyinanlilg......srpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

ekstgtshsvkQLQFTKWPDHGTPASaDSFIKYIRYARKSHLTG-PMVVHCSAGIGRTGVFLCVDVVFCaivkNCSFNIMDIVAQMREQRS-GMVQTKEQ
           | ... |||||.| . . ... ... |.    | | .|||||||||||.... . . .    .. ... ...|..||||. |.||| ||
...........qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRplgavqtpeQ

YHFCYDIVLEVLR
|.|.|. .|..|.
yrflyefellllk
0043147 (Phosphotyrosine protein) phosphatases II 205-406 3.7e-40 132.8 In-house 4-154 (172) alignment 
Range on Protein: 205-406
Range on HMM: 4-154/172.0
SKDYINASYIRIVNCGEEyfYIATQGPLLSTIDDFWQMVLENNSNVIAMITREieggiikcyhywpislkkplelkhfrvflenyqilqyfiirmfqvVE
. |||||||. .. .  .  .||||||| .|..|||.|. |.. ..| ..|..                                             . 
gsdyinasyldlyyipdr..fiatqgplrntladfwrmlkelgithivnltel.............................................ly

KSTGTSHSVKQLQFTKWPDHGTPaSADSFIKYIRYARK---SHLTGPMVVHCSAGIGRTGVFLCVDVVFcaivknCSFNIMDIVAQMREQRSGMVQTKEQ
  .. .... |.... |||||.| ... ... ... ..       ||..||||||.||||.. . . .       ..... ..||..||.|.|.||...|
dpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

YHFCY
|.|.|
yrfly
0051429 (Phosphotyrosine protein) phosphatases II 206-418 7.6e-48 158.8 In-house 4-230 (272) alignment 
Range on Protein: 206-418
Range on HMM: 4-230/272.0
KDYINASYIRIVncGE---EYFYIATQGPLLSTIDDFWQMvLENNSNVIAMITREIEGGIIKCYHYWP----------ISLKKPLELKHFRVFLENYQIL
 .||||...     |    . ......|||  |..|||..  |.. ..| ....| | |  ||. |||           .   . .. ..||.|  ...|
sgyiNardvggy..grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

QYFIIRMFQVVEK-STGTSHSVKQLQFTKWPDHGTPASAdsFIKYIRYARKshlTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFN--------IMD
 ..|.|..... . |.|... | .|..| |||||.| .|  ... ... ..    ||..||||||..|||.. ... .   . ... ..        . .
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld...ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

IVAQMREQRSGMVQTKEQYHFCYDIVLEVLRKLLT
.|...|.|| |.||| |||.|.|...||.||.||.
aveelraqrpgavqteeqylflyeallellrslls
0036282 (Phosphotyrosine protein) phosphatases II 206-407 5.5e-43 142.0 In-house 2-164 (174) alignment 
Range on Protein: 206-407
Range on HMM: 2-164/174.0
KDYINASYIRIVNCGEeyFYIATQGPLLstiddFWQMVLENNSNVIAMITREIEGGIIKCYHYWPIslkkplelkhfrvflenyqilqyfiirmfqvveK
.||||||.. .. . .   .||.||||      ||.|. |...... | ..|.| |. ||..|||                                  .
sdyinaspldlsyitp..rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................l

STGTSHSVKQLQFTKWPDHGTPASADsFIKYIRYARKSHLT---GPMVVHCSAGIGRTGVFLCVDVVFCAIVkNCSFNIMDIVAQMREQRSGMVQTKEQY
..  .... |.... |||||.| ..  ... ...... ..    ||..||||||.||||.. . . . . .  .   ...|.|...| ||.||||| .||
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

HFCYD
.|.|.
rflyy
0051082 (Phosphotyrosine protein) phosphatases II 206-410 1.1e-31 104.8 In-house 3-150 (151) alignment 
Range on Protein: 206-410
Range on HMM: 3-150/151.0
KDYINASYIRivncgeEYfYIATQGPllstIDDFWQMVLENNSNVIAMITREIEGGiiKCYHYWPISLkkplelkhfrvflenyqilqyfiirmfqvvek
 ||||.||.       .. .....||     .||.... |.. ..| ... | | |  .|..|.|                                   
sdyinfsyvt......gg.lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

stgtsHSVKQLQFTKWPDHGTPASADSFIKYIRYARKsHLTGPMVVHCSAGIGRTGVFLCVDVVFCAivkncsFNIMDIVAQMREQRSGMVQTKEQYHFC
     . |...... |||.|.| | |........... .  ||..||||||.||||.. ... . .       ... ......|..| |.||...|. |.
.....ievlhipildwpdpglplsfdavleflellld.kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

YDIVL
.  .|
lfall
0049260 (Phosphotyrosine protein) phosphatases II 222-407 1.1e-38 127.6 In-house 8-144 (152) alignment 
Range on Protein: 222-407
Range on HMM: 8-144/152.0
EYFYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWpislkkplelkhfrvflenyqilqyfiirmfqvvekstgtshsvkQLQFTKW
 . .||||||.  |..|||.|. |.. ..| |.|.. | | .||..|.                                             | ... |
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................qylhlpw

PDHGTPASADSFIKYIRYARK--SHLTGPMVVHCSAGIGRTGVFLCVDVVFcaivknCSFNIMDIVAQMREQRSGMVQTKEQYHFCYD
||||.| ... ..  ..  .|   .  || .||||||.||||.. . . .       . ... ..||..||.|.|.|....|. |.|.
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 224-407 9.1e-20 65.7 In-house 5-197 (198) alignment 
Range on Protein: 224-407
Range on HMM: 5-197/198.0
FYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTG--TSHSVKQLQFTKW
 ||||| ||  |. |||||| |  |  | |.  .          ||| .     .   . |  .       . |  . .....|   ..  . . ||| |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGTPASAdSFIKYIRYARK------SHLTGPMVVHCSAGIGRTGVFLCVDVVFCA--IVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYD
 .. ||  |  |. ..  .|.           |..|||| | | ||||...|.   .    |    .....  ..|. | |.. . ..| | |.
kekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 224-407 9.7e-20 65.6 In-house 6-198 (199) alignment 
Range on Protein: 224-407
Range on HMM: 6-198/199.0
FYIATQGPLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTG--TSHSVKQLQFTKW
 ||||| ||  |. |||||| |  |  | |.  .          ||| .     .   . |  .       . |  . .....|   ..  . . ||| |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGTPASAdSFIKYIRYARK------SHLTGPMVVHCSAGIGRTGVFLCVDVVFCA--IVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYD
 .. ||  |  |. ..  .|.           |..|||| | | ||||...|.   .    |    .....  ..|. | |.. . ..| | |.
kekttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_hpo-7_pd Subfamily hpo-7 227-412 1.7e-22 74.6 In-house 42-226 (263) alignment 
Range on Protein: 227-412
Range on HMM: 42-226/263.0
AtqgpLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENYQIlqYFIIRMFQVVEKS--TGTSHSVKQLQFTKWPDH
     |. ||| |.|..  ....|..|..   | |. || .|.|. . . . |..  |   . |     ...  ....      . | ||. ... |...
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiek

GTPASADSFIKYIRYARKShltGPMVVHCSAGIGRTGVFLCVDVVFCAIVKN------CSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV
  |  | . .. .. ||.|    ..|||||.||||.  |  ...|.  ....        .. . .. ..|..|.. ..|  |  |   .||..
ndpelareilnilkvarns...kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 231-405 1.2e-21 71.5 In-house 99-280 (302) alignment 
Range on Protein: 231-405
Range on HMM: 99-280/302.0
PLLSTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKHFRVF-------LENYQILQYFIIRMFQV--VEKSTGTSHSVKQLQFTKW
|  ||.. .| .. . |  ... ..  .|..  || .|.   ... |..... |        ||..   . | .   ..   .| . . ..|. |.|. |
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PDHGTPASADSFIKYIRYARkSHLTgPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFC
||||.|. |.. .. ...   |. .  ..||||||.|||| .. .       .|.   ....||  .|. | | ||...|  . 
pdhGapkeaytaldilkfce.sykk.nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 232-412 2.8e-23 77.3 In-house 39-220 (255) alignment 
Range on Protein: 232-412
Range on HMM: 39-220/255.0
LlsTIDDFWQMVLENNSNVIAMITREIEGGIIKCYHYWPISLKKPLELKHFRVFLENyqILQYFIIRMFQVVEKST--GTSHSVKQLQFTKWPDHGTPAS
|  |.| |.|..  ....|..|..   | |. || .|.|. . . | |..  |   .    .  ..|  ... . .     | ||  ... |... .|  
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWieknaPel

ADSFIKYIRYARKShltGPMVVHCSAGIGRTGVFLCVDVVFCAIVKN------CSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV
|    . .. .|.|    ..|||||.||||.  |  ...|.  ....        .. . .. ..|..|.. ..|  |  |.  .||..
areilnilkvvrds...ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
0048076 (Phosphotyrosine protein) phosphatases II 268-411 6.3e-26 86.2 In-house 2-141 (145) alignment 
Range on Protein: 268-411
Range on HMM: 2-141/145.0
YWPISLKKPLELKHFRVFLENYQILQYFIIRMFQVVEKSTGTSHSVKQLQFTKWPDHGTPASADSFIKYIRY---ARKSHltGPMVVHCSAGIGRTGVFL
|||.     | |  . . |.  .. .. | . . .    .. .. . |.... |||||.| ... ... ...   |.|..  ||..||||||.||||.. 
ywpseilpglylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg..gpvlVHCsaGvgRtgtlv

CVDVVFCaivknCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLE
. .....     ..... ......|.||.|.|.. .|..|.|. .||
aaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 299-407 1.2e-23 78.8 In-house 48-139 (144) alignment 
Range on Protein: 299-407
Range on HMM: 48-139/144.0
MfqvvekstgtshsVKQLQFTKWPDHGTPASADSFIKYIRYARKSHL-TGPMVVHCSAGIGRTGVFLCVDVVFcaivkNCSFNIMDIVAQMREQRSGMVQ
.             . |.... |||||.| ... ... ... .. .   ||..||||||.||||.. . ....      . ... ...|..|..|.|.|.
e.............giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavp

TKEQYHFCYD
. .|..|...
npgqlrfLle
subfamily_DSP23_pd Subfamily DSP23 303-407 1.2e-09 33.0 In-house 39-140 (148) alignment 
Range on Protein: 303-407
Range on HMM: 39-140/148.0
VEKSTGTSHSVKQLQFT--KWPDHGTPAsADSFIKYIRYARKSHLTGP-MVVHCSAGIGRTGVFLCvdvvfCAIVKNCSFNIMDIVAQMREQRSGMVQTK
 |..   .... .| .   . .|.  ||  .   ...|   ...  .  . |||  | |||| .|      | .||.  .   . .|..|..| | |.| 
teegrphveatpnltlvrlriddyhppa.leqvvefvrvveeaeekneavsvhcllgrgrtgtmla.....cylvkerklaaaeaiaevrrlrpgsvetv

EQYHFCYD
|| .  .|
eqeklvrd
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 309-413 1.3e-20 68.1 In-house 87-194 (440) alignment 
Range on Protein: 309-413
Range on HMM: 87-194/440.0
TSHSVKQLQFTKWPDHGTPASADSFIKYIRYARKSH---LTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFC
 |...|| ..  |||.| |  |   .| |.   .|.     ||..|||||| ||||| ..|| ..    ..   .|. ..  ||..|  |||| ||| | 
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

YDIVLEVL
.. ||| |
heavlegl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 311-411 2.8e-16 54.2 In-house 215-342 (350) alignment 
Range on Protein: 311-411
Range on HMM: 215-342/350.0
HSVKQLQFTKWPDHGTPASADSFIKYIR--------YARKSHL----TGPMVVHCSAGIGRTGVFLCVDVVFC--AIVKNC-------------SFNIMD
. | |||. .|.| ..     |... .            .|||    . |..||||||.||||... .| ..    |..|                 |  
yvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisi

IVAQMREQRSGMVQTKEQYHFCYDIVLE
|| ..|.||  |||...|. |.|. .| 
ivnelrkqrismvqnldqfifiYeallf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 311-412 2.7e-11 37.4 In-house 218-343 (349) alignment 
Range on Protein: 311-412
Range on HMM: 218-343/349.0
HSVKQLQFTKWPDHGTPASADSFIKYIRY---------AR---KSHLTGPMVVHCSAGIGRTGVFLCVDVVFC--AIVK---------NCSFN-IMDIVA
. . |||.  |.| ..     |... .           ||   ..  . ...|||||| |||||.  .|...     ..         .  .. |. || 
yellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivn

QMREQRSGMVQTKEQYHFCYDIVLEV
..| ||  |||   |. ..|. .|. 
elrkqrismvqnlaqfiaiyealLky
PTEN_1 312-402 4.9e-08 28.0 In-house 94-182 (196) alignment 
Range on Protein: 312-402
Range on HMM: 94-182/196.0
SVKQLQFtKWPDHGTPASADSF--IKYIRYARKSHL-TGPMVVHCSAGIGRTGVFLCvdvvfCAIVKNCSFNIMDIVAQMREQR-SGMVQTKEQY
 |..|.|  ..|||.|  .  |  .| .  ...|.   .  .||| ||.||.|. ..     .  ..   ..  . .. .||.|  |.... .| 
gveylhf.pieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva.....ayLmykgkltadeAlelvrekRppgapnspsqe
PTPc_DSPc_SM00012 313-411 1.4e-34 113.8 In-house 2-105 (105) alignment 
Range on Protein: 313-411
Range on HMM: 2-105/105.0
VKQLQFTKWPDHGTPASADSFIKYIRYARKSHL----TGPMVVHCSAGIGRTGVFLCVDVVFCAIVKN-CSFNIMDIVAQMREQRSGMVQTKEQYHFCYD
||....|.|||||.| ..||.....|. .|..     ..|.|||||||.||||.| ..|.. . . |.  ...| .|| ..|.||.|||||.||| |.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

IVLE
..||
alle
subfamily_PTEN_pd Subfamily PTEN 313-402 1.5e-06 23.4 In-house 79-169 (184) alignment 
Range on Protein: 313-402
Range on HMM: 79-169/184.0
VKQLQFTKWPDHGTPAS--ADSFIKYIRYARKSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSfNIMDIVAQMREQRSGMVQTKEQY
 .... ..  || .|     ..... |.   ..  .  .|||| || ||||| ..  .. . .... . ..... |..| . .  |.   | 
dgrvavypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekae.ealelfaeaRtknkkgvtiPsqr
0038934 (Phosphotyrosine protein) phosphatases II 318-406 4.4e-13 44.8 In-house 82-170 (194) alignment 
Range on Protein: 318-406
Range on HMM: 82-170/194.0
FT--KWPDHGTP---ASADSFIKYIRYARKSHLTGPMVVHCSAGIGRTGVFLCvdvvfCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCY
.    .||.||.   .  ..|.. .    . .  |  .||| ||.||||....     ..... . ..  . .| .|| | |.... ....  .
ylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlva.....aYLiyrlgmsaeeAialfrekRpgaipnqdyleall
subfamily_PTPDC1_pd Subfamily PTPDC1 320-408 5.4e-11 37.3 In-house 89-171 (182) alignment 
Range on Protein: 320-408
Range on HMM: 89-171/182.0
KWPDHGTPaSADSFIKYIRYARKSHLTGPMVVHCSAGIGRTGVFLCVDVVFCAivkncSFNIMDIVAQMREQRSGMVQTKEQYHFCYDI
 |.|.|.. | .. .  .. .  .   | . ||| || ||||| ... .|.       ...  . .  .|..|.  .||.|| ... . 
gwkDygva.sleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyak.....rltaekaiklvrskrpksiqtreqvelvkef
0048567 (Phosphotyrosine protein) phosphatases II 321-405 9.7e-07 23.3 In-house 45-131 (157) alignment 
Range on Protein: 321-405
Range on HMM: 45-131/157.0
WPDHGtPASADSFIKYIRYARK-----SHLTGPMVVHCSAGI---GRTGVFLCvdvvfCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFC
. |.| | . . ....|... |     ..  .. .|||.||    |||.....     | ... ..|.  ...| .|  | |.|   ... . 
ffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLig.....cYlilhlgftpeeaiaplrivrpgsvpfrdasyll
subfamily_PRL_pd Subfamily PRL 321-400 6.4e-06 20.3 In-house 63-138 (151) alignment 
Range on Protein: 321-400
Range on HMM: 63-138/151.0
WPDHGTPAS--ADSFIKYIRYARKSHLTGPMVVHCSAGIGRTGVFLCVDVVfcaivkNCSFNIMDIVAQMREQRSGMVQTKE
. | ..|..   ..... .. . | .    . ||| ||.||. |.... ..      .. ..  | |  .||.| | . .| 
fddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalali......eaGmkyedavefirekrrgainskq
subfamily_CDC14_pd Subfamily CDC14 335-405 2.1e-09 31.7 In-house 254-316 (328) alignment 
Range on Protein: 335-405
Range on HMM: 254-316/328.0
KYIRYARKShlTGPMVVHCSAGIGRTGVFLCvdvvfCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQyHFC
|... | |.  .| ..||| ||.|||| ..      | ..|.  |.  ...| .|  | |.| .. | .|.
kfleiaeka..eGaiavhCkaGLGrtGtLia.....cylmkhyrftaaeaiawlricrPGsvigpqq.kfl
subfamily_CG42327_pd Subfamily CG42327 345-412 7.8e-15 49.3 In-house 246-314 (319) alignment 
Range on Protein: 345-412
Range on HMM: 246-314/319.0
LTGPMVVHCSAGIGRTGVFLCVDVVFCAIVKN-CSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEV
  ||.||||| |.||||. .  |. .  . ..  | .| ..| ..|..|.  |.||||| | | .. | 
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 348-413 1.2e-16 55.4 In-house 230-295 (297) alignment 
Range on Protein: 348-413
Range on HMM: 230-295/297.0
PMVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
...||||||.||.|| .  ||.   . |.   ..  |. ..||||. .||| ||....||.||. |
yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 349-414 6e-11 36.6 In-house 1-66 (69) alignment 
Range on Protein: 349-414
Range on HMM: 1-66/69.0
MVVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR
||||||.| |||| |... |    |  .   .|.. |  ||  |  ||  . .| | .| . | |.
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_eak_pd Subfamily eak 349-415 1.8e-08 28.2 In-house 239-307 (332) alignment 
Range on Protein: 349-415
Range on HMM: 239-307/332.0
MVVHCSAGIGRTGVFLCVDVVFCAIV--KNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLRK
 .. .. |  |.|||. .|..   |   |. .. . |.. .....|   | .. |. | |.|||. |..
piiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllr
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 350-414 1.5e-10 35.3 In-house 1-65 (69) alignment 
Range on Protein: 350-414
Range on HMM: 1-65/69.0
VVHCSAGIGRTGVFLCVDVVFCAIVKNCSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVLR
|||||.| |||| |. . |    |  .   .|.. |  ||  |  ||  ...| | .| . | |.
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealk
subfamily_ptpA1_pd Subfamily ptpA1 377-413 6.5e-09 30.0 In-house 362-398 (418) alignment 
Range on Protein: 377-413
Range on HMM: 362-398/418.0
CSFNIMDIVAQMREQRSGMVQTKEQYHFCYDIVLEVL
  ||.. || ..|||| ||||  ||| |||  .|. .
idfnlfsivlklreqrpgmvqqleqylfcyktildei