Gene PTPN3 in Homo sapiens

Synonym: PTP-H1, PTPH1, RP11-18A3.3, PTPN3

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN3
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP080_AA protein Get Run
HsapP080_AA_639-914 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
FERM_N FERM N-terminal domain 44-122 1.1e-25 79.8 Pfam-A 1-80 (80) alignment
Range on Protein: 44-122
Range on HMM: 1-80/80.0
IHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKG-GFPCTLHFRVRFFI
...||| | ...| ...||.|||..| ..||.||.|||||. ..|. .  .||...| .|.|..  | |.||..||.|..
VrlLDgtvkevtvddsktgavlletVckrlglteteyFgLafkedkknesnwLdhdktlreqgveegkpttlllrvkfyv

FERM_M FERM central domain 124-233 7.4e-24 74.5 Pfam-A 1-126 (126) alignment
Range on Protein: 124-233
Range on HMM: 1-126/126.0
DPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYN-SSIHHPGYLSDSH-------FIP--------DQNEDFLTKVESLHEQHS
||| ...| ...|...|.| |. |.||.|. ..|..||....| ..||.. .. .  ..| ..        ..|         ..... ...   |....
dpnpkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllpvsprllkkekskqleqrileahknva

GLKQSEAESCYINIARTLDFYGVELH
||...||.  |...|..|  |||.|.
glslaeaklkylqaaqslpdyGvslF

FERM_C FERM C-terminal PH-like domain 239-323 4e-25 78.2 Pfam-A 3-86 (90) alignment
Range on Protein: 239-323
Range on HMM: 3-86/90.0
HNLDLMIGIASAGVAVYRKYICT--SFYPWVNILKISFKRKKFFIHQRQkqaESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK
.. ||..|... |. .|.|  .   . .|| .| |.|||.|||.|..|.   |.... . |.. ..|..|.|.|.|.|.|..|. ..
kgtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrd...ekkkdvlkFyssqlrvnklllklcienhdlfrrrr

PDZ PDZ domain (Also known as DHR or GLGF) 522-605 8.7e-22 67.2 Pfam-A 2-80 (81) alignment
Range on Protein: 522-605
Range on HMM: 2-80/81.0
IRITPDEDGKFGFNLKGGVDQK-MPLVVSRINPEsPADTCIPkLNEGDQIVLINGRDISEHTHDQVVMFIKASREshsrELALVI
... ... |..||.|||| |.. ....||...|  .|. . . |.|||.|. .||.|.....||..| .|| ...    |..|.|
vslekekrgglGfslkggsdkrdkgifvsevvpg.gaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkg....evtLti

0050432 (Phosphotyrosine protein) phosphatases II 640-914 8.5e-100 329.3 In-house 27-300 (308) alignment
Range on Protein: 640-914
Range on HMM: 27-300/308.0
TLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIpaANLVNKYIATQGPLPHTCAQF
...  . .|.| |..| .  .||.|...|| | ...|.||.| |||||||.|||| .|| |... ||||||||.. .   .| .|.||||||||.|.. |
svldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgys..sklprkfIatqgPlpntvedF

WQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDP--PDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVN
|. ||.|. ..|||||.|.|.|| ||.||||.    .....|.|.. . ||.    |. |.. .||...||..||||..| .|||||||.. ...|.|..
wrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfle

YVRSLRvDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE
.||. . ...|..||||||.||||........... |..  . ....|.|.| ||..|||| .||.|...|.|  ..
lvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk

0039614 (Phosphotyrosine protein) phosphatases II 640-913 1.5e-87 289.1 In-house 17-289 (297) alignment
Range on Protein: 640-913
Range on HMM: 17-289/297.0
TLEGSMAQLKKGLESGTVLIQFEQLYRKKPGlaITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNED------YINASYVnmeiPAANL-VNKYIATQGPL
. .  . .|.| ......| .||.|.. ||   ...|.||.| |||||||.|||| .|| |.....      |||||||    .  .|  .|.|||||||
svldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv....dgydlltrkfIatqgPl

PHTCAQFWQVVWDQKLSLIVMLTTLTERGRtKCHQYWPDPPDvmNHGGFHIQCQSEDCTIAYVSREMLVTNtqTGEEHTVTHLQYVAWPDHGVPDDSSDF
|.|.. ||. ||.|. . |||||.|.|.|| ||.||||.  .  ..|.|.. . ...    |. |.. |||  .||..||||.||. |||||||......
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslell

LEFVNYVRSLRV---DSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
|||...||. .    ...|||||||||.||||..... ..... |..  . .|..|...| || ..||| |||.|...|.|  .
leflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell

subfamily_Ptp69D_pd Subfamily Ptp69D 640-914 2.3e-59 196.0 In-house 8-287 (307) alignment
Range on Protein: 640-914
Range on HMM: 8-287/307.0
TLEGSMAQLKKGLESGTVLiQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVNmeipAANLVNKYIATQGPLPH
.|| .. . |.  . | .   .|.| ...  .  ....   |. ||||.|. ..| ||| |.      . ||||||...    . .  .|.|| |.|.  
dleealksrkrdtdfglak.eyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik....gykekkkfiaaqdPvea

TCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQ-----TGEEHTVTHLQYVAWPDHGVPDDS
|   ||.....|.. |||||. |||  | ||..|||.  | ...|   ... ||. .  |. ||. |....       ... |.  .| .|.|  ||. .
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

SDFLEFVNYVRSL-RVDSEPVLVHCSAGIGRTGVLVTMETAM--CLTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE
   |.... ||.| . .  |..|||||| ||.|..|...  .  . .| .. |.  ..|...| || ..||   ||.|.  |.|   .
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdif..etvkdLrsqRnllvqsleqYvflyralldyss

subfamily_PTPN3_pd Subfamily PTPN3 641-917 1.8e-146 481.4 In-house 1-279 (280) alignment
Range on Protein: 641-917
Range on HMM: 1-279/280.0
LEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE-DYINASYVNMEIPAANLVNKYIATQGPLPHTCAQF
|. |...||.|||||.||.||||||||||||||. |..|.||.||||.|.||||.||| |. .| |||||.|||||||...|||.||||||||..|...|
lresllllkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdf

WQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYV
||.||.|| |||||||||.||||.|||||||.. | ...|.|...|..||.| .|| ||.......| ||.....|||.|||||||||||.||||||. |
WqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv

RSLR-VDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGL
|.|| ...|||.|||||||||||||...|||..|.|.. |.|||||||.|||||||.|||.|||||||||||.||||.|
rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyeeil

subfamily_PTPN14_pd Subfamily PTPN14 645-911 5.7e-76 250.4 In-house 13-294 (300) alignment
Range on Protein: 645-911
Range on HMM: 13-294/300.0
MAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG----NEDYINASYVNMEIPAANlvNKYIATQGPLPHTCAQFW
. .|.| ||.| |  ..|.. .|.    .. ||||.| .|||.||||||. .|| |.     ...||||| ... . ...   .||..||||..|. .||
akilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggke..rsyivaqgPleltvqdfW

QVVWDQKLSLIVMLTTLTERGRTKCHQYWPDP---PDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVN
|.||.|...||||||  .| |..|...|.|.     . ...| |... .  . . ... . . .    ..|| || ||||. |||||||.| ..||....
qmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLe

YVRSLRVDS----------EPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
 |.|.|  .           |||||||||.||||||.. .  .   | |  |    .....| || ..||| .||||| .....
evqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik

subfamily_PTPN13_pd Subfamily PTPN13 647-913 6.9e-84 276.3 In-house 3-269 (273) alignment
Range on Protein: 647-913
Range on HMM: 3-269/273.0
QLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIpaANLVNKYIATQGPLPHTCAQFWQVVWDQ
.|.| |....   .|..|   || .  . .|  .| |||||..||||| ||| |...  |||||......   .   .|||.|||||.|.. |||.||.|
alqkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpv..gkdeyeyiacqGPlPetvkdfwqmvweq

KLSLIVMLTTLTERGRTKCHQYWPDPP--DVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV
| ..|.|.|.  |.|. |||.|||.     .. .. ....        ..| |.. |.....|| . |.||..|.|||||||  . ..|.|| .||.|. 
kaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt

DSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
|. |..|||||||||.|.|.|..... | ||. ..   .||||.|.||  .|||. || || .||| | 
dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 648-911 3.1e-71 235.0 In-house 14-278 (318) alignment
Range on Protein: 648-911
Range on HMM: 14-278/318.0
LKKgleSGTVLI--QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNME-IPAANLVNKYIATQGPLPHTCAQFWQVVW
|..   ||..|.  ..|.| |..   . . .  | |  |||| ..|.||.|||.||  |.  .. |.| . |.  .  ..|||.|.|||.|.  ||..||
lre...sGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvW

DQKLSLIVMLTTLTERGRTKCHQYWPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-
.|. ..||||| ..|||..|.|.|||.  . ...|  ... ..|  .  || ||. ||.|.. |. .|   .| .|||.|||......|..|  |..   
eqnsavivmltqeeergkakvhryWPsk.gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqq

-VDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
  . .|..||||||.||||| ..... .   . .  .  ...|...|.|| .|||| .||.|. ...| 
ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlle

0047943 (Phosphotyrosine protein) phosphatases II 649-910 1.3e-89 295.5 In-house 6-269 (273) alignment
Range on Protein: 649-910
Range on HMM: 6-269/273.0
KKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL-QGNEDYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQK
.| | ....| .||.|.. || | ...|.||.|.|||||||.|||| .|| | .|. ||||||||    .  || .|.||||||||.|.. ||. ||.|.
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyv....dgynlkrkfiatqgPlpntvedfwrmvweqn

LSLIVMLTTLTERGRTKCHQYWPDPPD--VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-
 ..|||||.|.|.|| ||.||||.  .  ....| |.. . ||.    |. |.. .||..|||..||||..|  |||||||.. ...|||...||. .  
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--DSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL
  ...||.||||||.||||........... |..  . .|..|...|.|| .|||| .||.|..||.|
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 652-908 9.4e-22 71.8 In-house 23-280 (302) alignment
Range on Protein: 652-908
Range on HMM: 23-280/302.0
LESGTVLIQFEQLYRKKPGLAItFAKLPQNLDKNRYKDVLPYDTTRVLLQ-GNEDYINASYVnmEIPAANlvNKYIATQGPLPHTC---AQFWQVVWDQK
|....|  .|...   |  |        .||.||. .||  .|...| |.  ...|.||| |  |.|  .  .. | .| |   .    ..||..|...|
ldtaevkkefkkidtmkvdlek.Ckafkknlkknqsedvpildsnlvkleaepdsyvnaskv..evPelt..rsiilaQlpkvdsedsveeFWrmvfqek

LSLIVMLTTLTERGRtKCHQYWP-DPPDVMNHGGFHIQCQSEDCTIAYV---SREMLVTNTQTGEEHTVTHLQYvaWPDHGVPDDSSDFLEFVNYV--RS
   .|.|    |  .   ....|    |  ..| . .  .  . . . .   . |.|  .       .|..|..  |... ||.  ..  . .  |  ..
ivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakvfakk

LRVDsEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEA
  .| |....    |.|| |...|. .|..  ...      .||...| ||. .|.. .|| ..  |
ikad.entvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyia

0036941 (Phosphotyrosine protein) phosphatases II 653-920 1e-90 299.3 In-house 11-284 (297) alignment
Range on Protein: 653-920
Range on HMM: 11-284/297.0
ESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE-DYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLI
 .  .| .||.|.. ..   .. |.||.||.||||||.|||| ||| |.... ||||||||    .  .| .|.||||||||.|.. ||. ||.|. . |
flalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyv....dgydlkrkfIatqgPlpntvedFWrmvweqnvtvI

VMLTTLTERGRTKCHQYWPDP-PDVMNHGGFHIQCQSEDC--TIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV---D
||||.|.|.|| ||.||||.  ......|.|.....|..      |. |.. ||.|..||..||||..|  |||||||.. ...|.|...||. .    .
vmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllps

SEPVLVHCSAGIGRTGVLVTMETAMCLTE---RNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQM
..|||||||||.||.|........... |   ..  . .|..|.|.|.||...||| .||.|..||.|  .  .|. .
ggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke

0043336 (Phosphotyrosine protein) phosphatases II 654-910 4.9e-87 287.2 In-house 19-274 (278) alignment
Range on Protein: 654-910
Range on HMM: 19-274/278.0
SGTVLIQFEQLYRKKPgLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKL
  ..| .||.|.. |.   ...|.||.| |||||||.|||| .|| |.      . ||||||||    .  |  .|.||||||||.|.. ||. ||... 
ktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv....dgynvprkfiatqgPlpetvedFwrmvwelgv

SLIVMLTTLTERGRTKCHQYWPdpPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-DSE
. |||||.|.|.||.||.||||   .....|.|.. ...|.    |. | . |||...||..||||..|..|||||||.. |..|.|...||. .  ...
ttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsng

PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL
|||||||||.||||........... |... . ....|...| ||...||| |||.|..||.|
pvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

0045098 (Phosphotyrosine protein) phosphatases II 654-914 3.2e-85 281.1 In-house 6-273 (278) alignment
Range on Protein: 654-914
Range on HMM: 6-273/278.0
SGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLlqgneDYINASYVNMEiPaanlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVM
|. .|..||.|..  .   ||.| .. |||||||||.|||| .||      |||||||...  |     .|.||||||||.|.|.||. .|... . |||
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVk.....dYINAsyidgy.p.....kkfIatqgPlpstvadfwrmlwelgitvivm

LTTLTERGRTKCHQYWPDpPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNT----QTGEEHTVTHLQYVAWPDHGVPDDS--SDFLEFVNYVRSLRV---
||.|.|.|| ||.||||.  .....|.|.. ..||. .  |. | .||||.    ...|...||||.|. |||||||...  . |||.....|. .    
ltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealklla

-----------DSEPVLVHCSAGIGRTGVLVTMETAMCLTerNLPIYPLDIVRKMRDQRAM-MVQTSSQYKFVCEAILRVYE
           ...|||||||||.||||.|| . . ..|   .  . .|..|...| || . .||. .||.|..|..|....
slllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

0051299 (Phosphotyrosine protein) phosphatases II 655-911 4.3e-92 303.9 In-house 23-284 (288) alignment
Range on Protein: 655-911
Range on HMM: 23-284/288.0
GTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ-----GNEDYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLS
 ..| .||.|....| | ...|.||.||.||||.|.|||| .|| |.     .. |||||||.    .  || .|.||||||||.|.. ||. ||.|. .
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi....dgynlkrkfIatqgPlpntvedFWrmvweqnvr

LIVMLTTLTERGRTKCHQYWPDpPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNT----QTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD
.|||||.|.|.||.||.||||.  .....| ... . ||.    |. |.. |||.    ..||..||||..| .||||||||. ...|.|...||. . .
vIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalas

-SEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
 . ||.||||||.||||........... |..  . .|..|...| || .|||| .||.||.||.| 
gggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle

0040438 (Phosphotyrosine protein) phosphatases II 657-916 9.2e-90 296.4 In-house 20-279 (317) alignment
Range on Protein: 657-916
Range on HMM: 20-279/317.0
VLIQFEQLYRKKPGlAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLI
.| .||.|.. |.   ...|.||.| |||||.|.|||| .|| |.      . ||||||||    .  || .|.||||||||.|.. ||. ||.|....|
lleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv....dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvi

VMLTTLTERGRTKCHQYWPDpPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD-SEPVL
||||.|.|.|| ||.||||.  .....|.|.....||.    .. |.. |......|..||||..| .|||||||.. ...|.|...||. . | ..|||
vmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvl

VHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEG
||||||.||||........... |..  . . ..|...| ||...||| .||.|...|.|  .  .
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

0045450 (Phosphotyrosine protein) phosphatases II 657-913 1.6e-86 286.1 In-house 29-304 (307) alignment
Range on Protein: 657-913
Range on HMM: 29-304/307.0
VLIQFEQLYRKKP--GLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ------GNEDYINASYVNMEI----PAANLVNKYIATQGPLPHTCAQFWQVVW
.| .||.|.. ..     ...|.||.| |||||||.|||| ||| |.      .. ||||||||.. .    .  .| .|.||||||||.|.. ||. .|
llkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlw

DQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNT-QTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR
.|. ..|||||.|.|.|| ||.|||||  .....| |.. . ||.    |. | . ||.. .|||..||||..| .|||||||.. ...|.|...||. .
eqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkal

V---DSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLP---IYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
    ...|||||||||.||||..... ..... |..     . .|..|...|.||  .||. .||.|..||.|  .
eelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_PTPN9_pd Subfamily PTPN9 657-911 2.8e-65 215.3 In-house 18-288 (297) alignment
Range on Protein: 657-911
Range on HMM: 18-288/297.0
VLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN-----EDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLI
.  ..... ....   .. .||. || ||||.||| || ||| |.        |||||..|.      .  . .|||||||..|.  ||..||.|.   |
lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvd....GykqkkafiatqGplkktvsdfWrmvWeqevlvi

VMLTTLTERGRTKCHQYWP-DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-------
|| | . |||| || |||| .  .....| ....  . ... .|. | . ..|..|.|. .||| |...|||.|||......|.... ||. .       
vmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkel

-------VDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
       ..  |..||||||||||| ..|.. ..   |.   .   . |...| ||| ..||  ||.|   |.| 
gdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 658-911 3.2e-62 205.4 In-house 25-281 (305) alignment
Range on Protein: 658-911
Range on HMM: 25-281/305.0
LIQFEQLYRKKPGLAITfaKLPQNLDKNRYKDVLPYDTTRVLLQG---NE--DYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIV
  |...||...  . ..  |  .|  |||.|.. ..|. |. |.    ..  ||||||||.    . .  .|||..||||..| |.||..... | | ||
eaqykslyeeeesidvg..kkeankaknrlkeitlldddriiltekeslddsdyinasyvd....gykrkkkyivaqgPlkntvadfWrliveekvstiv

MLTTLTERGRTKCHQYWPDPPDV-MNHGGFHIQCQSEDCTIAYVSREMLVTN-TQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDS--EP
||| | | |. ||.||||.     ...| |... .||  .  |. |.. ...  .  |..||...|   |||||||. .. .|.... |.  .  .   |
mltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvp

VLVHCSAGIGRTGVLVTMETAM--CLTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAILR
.|||||||.||||| .... |.  . .|  . ..  ......| .|  ||||  || |. .|.  
llVhCsagvgRtGvfiavdialerlkkEevvdvf..evlkqlRskrmkmvqtldqYvflhdalde

0046845 (Phosphotyrosine protein) phosphatases II 659-913 1.1e-90 299.2 In-house 4-274 (284) alignment
Range on Protein: 659-913
Range on HMM: 4-274/284.0
IQFEQLYRKKPGL--AITFAKLPQNLDKNRYKDVLPYDTTRVLLQ------GNEDYINASYVNME-IPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLS
 .||.|.. .. |   ...|.||.||.||||||.|||| .|| |.      .. ||||||||..  ..  .  .|.||||||||.|.. ||..||.|. .
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

LIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQ-TGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD---
.|||||.|.|.||.||.||||.  .|...|.|.. . ||.    |. |.. .||.. |||..||||..| .|||||||....|.|||...||.|. .   
vIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpg

SEPVLVHCSAGIGRTGVLVTMETAMCLTERNL---PIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
..|..||||||.||||........... |..     . .|..|...|.|| .|||| .||.||.||.|  .
ggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 659-915 1.6e-75 248.8 In-house 19-278 (281) alignment
Range on Protein: 659-915
Range on HMM: 19-278/281.0
IQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNME-IPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTL
 ..|.|.    . . | .| ..|  ||||...  || ||| .. ||.  |. |.| . .|. .  ..|||||||.|.....|||.||.|| |.|||.|  
eeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtre

TERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVtNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE--PVLVHCSA
 | |. |||.||||.   .. | .... ..|  .  |..|.. . ....||. .|..|.|.||||||||......||| . |..|.  ..  |...||||
ieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsa

GIGRTGVLVTMETAMCLTERN-LPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE
|.||||. .......   |..  .. . ..|...| .| .||||  ||.||  |.|.. ..
GvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 659-913 3.7e-41 136.1 In-house 20-277 (307) alignment
Range on Protein: 659-913
Range on HMM: 20-277/307.0
IQFEQLYRKKPGlAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG---NEDYINASYVNMEIPAanlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLT
 .|..| .|.|  ..|   .  | |||||.||   | .|....      ||| | |. . |      .|.|..||||  |  .|| .. ..|.  ..|| 
defrvlakktpe.gvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikp....kkficaqgplentqysfwamaiqekvesvimlc

TLTERGRTKCHQYWPDPP---DVMNHGGFHIQCQSED-CTIAYVSREMLVTNTQ---TGEEHTVTHLQYVAWPDHGVPDDSsdfLEFVNYVRSLRVDSEP
 . | .. ||.||||       |. . .  |  .     ..|     . ||. .   ...  |..|||.  |||.|||.     |  .| . . | | .|
kvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqin...ltainlleavrydtnp

VLVHCSAGIGRTGVLVTMETAMCLTERNLPI-YPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
|.||||||.||.| .|..   .    .        ..|...|.||   .||  || ..   .|  .
vvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 659-911 7.9e-38 124.9 In-house 19-291 (301) alignment
Range on Protein: 659-911
Range on HMM: 19-291/301.0
IQFEQLYRKKPGLAiTFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE-------DYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLI
 |...|.....  . |     .|   ||.|.. .||  |..|. ..       .||||||..    . .  .|.||.|||. .| ..||...|..| . |
eqykelkegedksc.tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyid....gysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMLTTLTERGRTKCHQYWPDPPDV-MNHGGFHIQCQSEDCTIAYVSREMLVTNTQT---------------GEEHTVTHLQYVAWPDHGVPDDSSDFLEF
||.| | |. ..||.||||.      . | |... ..|     .| |.. |. ...                . ..|. || . ||..||  .    |. 
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqv

VNYV--RSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
.. |  |  ...  ||.||||....|.|| .... ..    ..  .   .... .| ..  .|.|  || .. ..| .
iddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm

DSPc_SM00195 660-913 8.4e-86 282.9 In-house 5-262 (263) alignment
Range on Protein: 660-913
Range on HMM: 5-262/263.0
QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN-----EDYINASYVNMEipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVML
.||.| ....   .| |. ..| .|||||..|||| ||| |. .     .|||||.|....    |  .||||||||||.|...||..||..| ..||||
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TTLTERGRTKCHQYWPDPP-DVMNHGGFHIQCQSEDCTI-AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-DSEPVLV
|   |.|..||..|||.   . ...| ......... .   .. |.. .|.... |...||..|| .||||||||. ...||....|.. .   |.|..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
|||||.||||..||.....   |..  .   .||...|.||..||||. ||.|..||||...
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 660-913 8.4e-86 282.9 In-house 5-262 (263) alignment
Range on Protein: 660-913
Range on HMM: 5-262/263.0
QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN-----EDYINASYVNMEipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVML
.||.| ....   .| |. ..| .|||||..|||| ||| |. .     .|||||.|....    |  .||||||||||.|...||..||..| ..||||
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TTLTERGRTKCHQYWPDPP-DVMNHGGFHIQCQSEDCTI-AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-DSEPVLV
|   |.|..||..|||.   . ...| ......... .   .. |.. .|.... |...||..|| .||||||||. ...||....|.. .   |.|..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
|||||.||||..||.....   |..  .   .||...|.||..||||. ||.|..||||...
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPRB_pd Subfamily PTPRB 660-915 5.1e-79 260.4 In-house 30-287 (293) alignment
Range on Protein: 660-915
Range on HMM: 30-287/293.0
QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL-----QGNEDYINASYvnmeIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVML
..|.|   .   |...|.|..| .||||...||||..|| |     . ..|||||.|    ||  |  ...||||||||.|  .||..||..| | ||||
eyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinany....ipgynsprefiatqGPlpetvddfWrmvwekkssiivml

TTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNtqTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR---VDSEPVLV
| | |.|..||..|||.  . ...|  ... ..|. .  .| ||.....  . ||..|.......|||||||.... .|.||. ||.      ...|..|
tqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivv

HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE
|||||.||||....... .   |..  .  . || ..| .|...||| .|| |. ...|.. ..
hCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk

subfamily_PTPN6_pd Subfamily PTPN6 660-912 1.5e-72 239.2 In-house 31-296 (306) alignment
Range on Protein: 660-912
Range on HMM: 31-296/306.0
QFEQLYRK--KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGNEDYINASYVNMEIPAANlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVM
.||.| ..  |  |  . .. |.|  ||||| .||.| ||| |      ..|||||.|.. |..  .  ..|||||| |..| ..||..||...  .|||
efeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd..ksyiatqgclettvsdFWrmvwqensrvivm

LTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT-NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE-----
.|. .|||. || .||||  .  ..|  .... ||. . .|. ||..|. ... .||..| .... .||||||| | . .|.|.. |.. . ..|     
ttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeag

PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDI---VRKMRDQRAMMVQTSSQYKFVCEAILRV
|..||||||||||| .. ... . | |..   ...||   |...|.||  .||| .||||| .||   
pivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky

subfamily_PTPRG_pd Subfamily PTPRG 660-912 1.1e-59 197.1 In-house 24-286 (563) alignment
Range on Protein: 660-912
Range on HMM: 24-286/563.0
QFE--QLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ------GNEDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLI
.||  |   ..  | ..... |.|  |||| ....|| .|| |.      .. |||||.|..      .  ...|||||||..|.  ||...|.|. ..|
efealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyid....GyqkskafiatqgplkdtfddFWrmiWeqnvaii

VMLTTLTERGRTKCHQYWPDpPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQ------TGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD
||.| |.|||| ||..|||   .... | .... ..|. .. | .|.. . |..      . .|..|.. .|  |||||||. |   | ||.     . .
vmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka

-SEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV
   |..||||||.||||... ..| .   ...  .  .......| || ..|||  || |. .|.| .
eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 660-914 5.4e-57 187.9 In-house 25-284 (290) alignment
Range on Protein: 660-914
Range on HMM: 25-284/290.0
QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ---GNED----YINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIV
||..|   .   ..| .  ..|  .||......||  |. |.   |..|    ||||.|..      .  ..|||||||...| ..||...|..| . ||
qfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik....gykekkqyiatqgpvsntlvdFWkliwqekvtiiv

MLTTLTERGRTKCHQYWPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQT-GEEHTVTHLQYVAWPDHG-VPDDSSDFLEFVNYVRS-LRVDSEPV
|||. .| |..||.|||||  |. . | |.|. ..|  .  |. |.. |.|... |....||..|  .|...| |.. ..  | . . ..   .   ...
mltniieegkvkCqqYWpds.dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsi

LVHCSAGIGRTGVLVTMETAM--CLTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE
.||||...||..|.....|..  | ||    ..  ......| |.  .|||  ||..... .|.  .
vvHCSdtvgrsavfcaaattinkcktegvidvf..qvlksqRiqkpgsvqtvqqyqgifqivltyld

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 660-907 3e-35 116.3 In-house 32-284 (310) alignment
Range on Protein: 660-907
Range on HMM: 32-284/310.0
QFEQLYRKKpGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG----NEDYINASYVNMEipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLT
|. .|  |.   ..|.    ... |||| ||.  ||.|| |.      |||| | ||. .     | . .| .|||| ||  .||.......   |..| 
qyrkldakq.dssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktn....ylrstficsqgplqhtiidfwrmifqeraesilllc

TLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSED------CT--IAYVSREMLVTNTQT-GEEHTVTHLQYVAWPDHGVPDDSSDFlefVNYVRSLRVDS
  .| || ||  |||       .|   .   ||       |   ...|  .. | .  .  .|  |. ...  ||| ||||.       |      .|  
kvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekcht...vpqrllaqvrh

EPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE
 |..||||||..|..|.|... ..  ..| | .   ... ... .||. .||  || ..  
gpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr

subfamily_PTPN12_pd Subfamily PTPN12 661-918 9.1e-71 233.1 In-house 20-282 (290) alignment
Range on Protein: 661-918
Range on HMM: 20-282/290.0
FEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN-----EDYINASYVNMeipaANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLT
 .. |...     . .. ..|  ||||||.||||..|| |. .     .|||||....     ..   .|||.|||||.|  .||...|.......||. 
lsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikg....vegkleyiaaqgPLpktlddfWrmiweknveivvmaC

TLTERGRTKCHQYWPDPPD-VMNHGGFHIQCQSEDCTI-AYVSREMLVTNTqtGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-DSEPVLVH
 . | |..||..|||.  .  ...| |......|. .   .. | . |..   .|...|. ..| ||||||||   .. ||... ||.|.  ...|..||
revelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvh

CSAGIGRTGVLVTMETAMCL-TERNL--PIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLV
||||.||||...... .  |  ....   .   |.|...| ||| .|||  ||..| .|.. . .. | 
CsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 661-913 3.5e-53 175.6 In-house 26-279 (315) alignment
Range on Protein: 661-913
Range on HMM: 26-279/315.0
FEQLYRKKPGL---AITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNME-IPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTT
|.| |   ||     .  ||  .| .|||| ....|| .|| |   |   .. ||| . |.  |  ..|||.|||.. .   ||..|...... ||||| 
fkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltn

LTERGRTKCHQYWPDPpdVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQtgEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDS-EPVLVHCSA
| |. . |. .||||    . .| . .  .||.    |  | . |.  .  . ..|  |.| .||| |||  .  .....  |.  . .|  ...|||||
lvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgd..nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsa

GIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
|.|||| ..|... .   | .  |   ......|..|  |||.  ||.|. .|.|  .
GvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 661-911 9.7e-42 137.9 In-house 26-277 (439) alignment
Range on Protein: 661-911
Range on HMM: 26-277/439.0
FEQLYRKKPGLAITFAKLPQNLD--KNRYKDVLPYDTTRVLLQGNE-----DYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVM
||..   .|  |   . . |. |  ||||||| ..| ||| ||         |||| |..         . |||||||  .|. .||..|...| . |||
fekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyik....Gyyddklyiatqgpkkettddfwrlviekktvtivm

LTTLTERGRtkchqYWPDPPDVMnHGGFHIQCQSEDCTIAYVSREMLVTNT--QTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV--DSEPV
|| | |  .     |||   .|. .|   .... .     || | . | |   .|  |.|| ...|.||||. || ..|  |.|.  . |     .  ||
ltnlvesyk.....ywpsdaevc.ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpv

LVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
.||||||.|||| ..... |.     .  .    ||. .|.||  |||.  || |. .|.| 
vvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 661-916 2.6e-25 83.7 In-house 28-283 (303) alignment
Range on Protein: 661-916
Range on HMM: 28-283/303.0
FEQLYRKKPGlAITFAKLPQNLDKNRYKDVLPYDTTRVLLQgNEDYINASYVNMEIpaanlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTER
||..    |   ..  .. .|.||||. ||.  | ..| |  .  || |||....       .| | || ||.||.|.|||.. .||.  ...| | .| 
fekvvsylpp.svsknqfvknmdknrfvdvicldhskvkls.dssyihasylelds.....skkailtqlplshtaadfwqmiieqkvkcvlllltdsey

GRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHL-QYVAWPDHGVPDD-SSDFLEFVNYVRSL-R--VDSEPVLVHCSA
 .   .  .|   | ..     |.              . |     |. ..  |. .| |||   .| | |. |.  .  ..|. |   ||.| .    .
dklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls

GIGRTGVLVTMETA-MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL-RVYEEG
| ||.| .  .||| . | . .  .  .  . ..|. |   ||  ||. .|   .   | ..|
gcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldng

subfamily_PTPRD_pd Subfamily PTPRD 662-912 1.5e-80 266.4 In-house 30-280 (564) alignment
Range on Protein: 662-912
Range on HMM: 30-280/564.0
EQLYRKkPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ-----GNEDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTT
... .. .   .. |. |.|  ||||.....||..|| |.      . ||||||...    . .  ..||||||||..|.. ||. ||.|. | ||||| 
kkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid....gyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltk

LTERGRTKCHQYWPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSA
| |.|..|||.|||.  .  ..|..... ..|     |. |.. ...... | ..|.. ....|||||||.   ..|.... ||.|.  |..|..|||||
leEkgkvkchkYWPek.gtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSa

GIGRTGVLVTMETAMC--LTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAILRV
|.||||. ....  .    .|... ||   .|...| || .|||| .|| |. ||||  
GVGRTGtfividamlerikeektvDiy..qyvkalrkqRnamVqteeQYiFiheailea

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 662-912 7.5e-59 194.6 In-house 41-292 (319) alignment
Range on Protein: 662-912
Range on HMM: 41-292/319.0
EQLYRK-KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ---GNE--DYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLT
 .. ..  ..   ||| |.|| ||||. ..|..| ..| |.   | |  ||||||.|.         .||||.||||. | | ||...|... | ||.||
rracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvt....GyqrkdkyiaaqGPldntladfWrmiweyncstivllt

tltergRTKCHQYWPDPPDvMNHGGFHIQCQSEDCTIAYVSREMLVTN-TQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV---DSEPVLV
      . || ||||   . .... |... .| . |  || |.. ... ..  .   .|   .  |||.|||| .||.. .|. || |.    . ....|
......kdkcsqywplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivv

HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR--V
|||||.||||| ..... .   ...  .   ..|| .|.||  .||   ||||.  |.|   .
hcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 662-841 9.5e-38 124.7 In-house 14-195 (297) alignment
Range on Protein: 662-841
Range on HMM: 14-195/297.0
EQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG---NEDYINASYVNMeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLT
. |.... | . . || .  | ||||.|.| .|.||| |..   ..||||| || .  |  .   ||| .||||  |  .||..|..| .  |||.. | 
dllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvf..pdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklq

ERGRTKCHQYWPDPPDVMNH-GGF---HIQCQSEDCTIAYVsREMLVTNTqtGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS
| || ||  |||.  .   . | .   ..   |..    ..  |. .      |.  |.| |...||||||| |  |   |   | |
edGrdkcapywpsvvqerlkagdvvveflsstsdefdrvil.telqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcs

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 663-916 2.2e-50 166.6 In-house 30-291 (325) alignment
Range on Protein: 663-916
Range on HMM: 30-291/325.0
QLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ-----GNEDYINASYVNMEIPAanlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTL
.|   . | | . | .|.| .|||.|.|...| .|| |.     .. |||||||.. ..      . ..|.| ||..|   .|..| | . |..|.|  |
gllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk....dvflaaqaPltatindlWrlvldWrcsvvvvlnel

tERGRTKCHQYWPDP-PDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS----LRV---DSEPV
 . |  .| .|||.   .  . ||.... .. .    || | . | ... ||  .|  .|. .|.| ||.   . .. ... |      ..     | |.
.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpi

LVHCSAGIGRTGVLVTMETAM--CLTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEG
|||||||.|||||.... .|.   ..| .. |.  . |.|.| .|  ||.|  || .. ||.  .|  |
lvhcsaGvGrtGvfislysalakvieesrvdif..gfvkklrkdrpsmvetvdqyiliyealveaymsg

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 664-910 1.6e-33 110.6 In-house 20-266 (281) alignment
Range on Protein: 664-910
Range on HMM: 20-266/281.0
LYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG------NEDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTL
|    |    |  . | |  |||| ..   | .|| |.         ||| | |.     .  |   || ||||   | |.||...|... . ||||  .
lpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyir....spflkrgyiltqgpkketradfwrmiwqenttaivmlcqf

TERGRTKCHQYWPDPPDVMNHgGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEfvnYVRSLRVDSEPVLVHCSAGI
.|  | || .|.|    .  .   ..  . || |.        .  .  || . .||  .  |||  ||. |  .|.    .| .|  | | ..|||||.
letnrekcaeyfprnahcclq.fdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlk...ilrkirarstppvihcsagv

GRTGVLVTMETAMCLTERNLPIYPL-DIVRKMR-DQRAMMVQTSSQYKFVCEAIL
||.| |...| |.      . .  . .|| ..|   ||  |||  || .. . .|
grsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll

subfamily_eak_pd Subfamily eak 664-840 1.9e-16 54.4 In-house 35-208 (332) alignment
Range on Protein: 664-840
Range on HMM: 35-208/332.0
LYRKKPGLAITFAKLPQNLDKNRYKdVLPYDTTRVLLQG----NEDYINASYvnMEIPaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTE
| .... |.|. ..  .....| .| ..|||   | |      .. |||||   .| .  .. .||| |  .       |||.| .||   ||.|    |
lddyqrllsisetarleavnrnvvk.ivpydrylvrltssqlnrlGyinasl..aefs..evGrkyiltGiasedkvfafwqmvleqkspaivqlledve

RGRTKCHQYWPDPP-DVMNHGGFHIQCQSEDCTIAYVSREMLVTntQTGEEHTVTHLQYVAWPDHGVPDdSSDFLEFVNYVR
 .  |  .|.||   .....| .......      .  | . ..  .  | | | | ..  | .  .|    ||| . . ..
lkleksdkyfpdktreelkfGildverkefvkrniletrllels..kGnethrvlhykvfGwtettlpk.yedflalrkvmk

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 668-915 3.4e-62 205.3 In-house 36-285 (319) alignment
Range on Protein: 668-915
Range on HMM: 36-285/319.0
KPGlAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE-----DYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGR
..   .. |. ..| .||||...|.|| ||| |.  .     ||||||...    . .  .|.||||.|| .|   ||..||... | .|||| |.|...
vnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfid....gyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklk

TKCHQYWPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVtNTQTGEE--HTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR--VDSEPVLVHCSAGIG
 |...|||.  .... | . .. ..|. .  |. |.. . |....|    .|.| || .||||.||...   |.... .|  |   .| |. ||||||.|
vklkkywpee.nfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvG

RTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE
|||  .... ..   ...  .    .|...| || .|||. .||||. ||.| . | 
RtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 668-912 3.7e-58 192.3 In-house 12-256 (284) alignment
Range on Protein: 668-912
Range on HMM: 12-256/284.0
KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ---GNE--DYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTtltergR
 .|   ||| |.|| ||||. ..|..| ..| |.   |.|  ||||||...         .|||||||||. | | ||...|... | ||.||      .
vngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfit....GyqrkdkyiatqGPldntladfWrmiweyncstivllt......k

TKCHQYWPDPPDvMNHGGFHIQCQSEDCTIAYVSREMLVTN-TQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV---DSEPVLVHCSAGIG
 || ||||   . .... |... .| . .  || |.. ... ..  .  ...   .  |||.|||| .||.. .|. || |.    . ....||||||.|
dkcsqywplkiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvg

RTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR--V
|||| ..... .   ...  .   ..||..|.||  .||   ||||.  |.|   .
rtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 668-911 1.5e-51 170.0 In-house 20-264 (283) alignment
Range on Protein: 668-911
Range on HMM: 20-264/283.0
KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-NEDYINASYVNMEIPAANlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCH
 | |  . |   .|  |||.....|.|  || |.  ..|||||... ..    .  .|||..|.|| .|   ||..|.|.| . ||||| | |  | || 
vpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykq.dkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

QYWPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVTNT-QTGEEHTVTHLQYVAWPDHGvPDDSSDFLEFVNYVRSLRVDS--EPVLVHCSAGIGRTGVL
||||     ...| | .  . |    ... .|.|. .   . ..  ..| |.. | . | ..   . |  .| |.||. .|   |..||||.|||||.|.
qyWPkr.GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavf

VTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
... ...     .  .    .|. || || |.|||  |||.| |..| 
iaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 669-911 8.7e-59 194.0 In-house 28-274 (515) alignment
Range on Protein: 669-911
Range on HMM: 28-274/515.0
PGLAI---TFAKLPQNLDKNRYKDVLPYDTTRVLL-----QGNEDYINASYvnmeIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTER
||  |   | |.   |  |||||..||||..|| |     . ..||.||||    ||. .  . |||.|||.. .   ||..|.... . |.|.| | | 
pgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasy....ipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkeg

GRTKCHQYWPD-PPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTgeEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD-SEPVLVHCSAGIG
 . || .|||| | | .. | ....  | ..    . |.. |.  .    .|||  ..  |||.||| ..| .| ..  |.. .   . |...|||||.|
dkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvG

RTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
||||.....  .   .    .  ...|...|..|  .|||  || |. .|.| 
rtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavle

0049772 (Phosphotyrosine protein) phosphatases II 669-910 7.7e-42 139.5 In-house 34-277 (314) alignment
Range on Protein: 669-910
Range on HMM: 34-277/314.0
PGLAITFAKLPQNLDKNRYKDVLPYDtTRVLLQG----NEDYINASYVNMEipaanlvNKYIATQGPLPHTCAQF----------WQVV--WDQKLSLIV
| | |..|.|. | |||||.|.||.| .|| |.|    . ||||||||.         .|.|||||||..|.  |          |..|  .|...  ||
peltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdiv

M---------------------LTTLTERGrtkchqywpdppdvmnhggfhiqCQSEDCTIAYVSremL-------VtntqtgeEHTVTHLQYVAWPDHG
|                     |..|...|                       ..   .....             .       |... .. .. .||..
msrdevladelsrLdaAlgKtpllildgng.......................neptaadlellk...eelydpelf.......erlgikylripvpDgs

VPdDSSDFLEFVNYVRSLrVDSEPVLVHCSAGIGRTGV-LVtmeTAMCLTERNLpiYPLDIVRKMRDQRA-----MMVQTSSQYKFVCEAIL
.| ...||.||.......  . .||||||.||.||||. .|   .|...  ...   . .... .| .|       ....  || |. ||.|
ap.lledfdeflefieea.dkggpvlvHCkaGkgRtgtfvv...aaylmkllgv..sleealedvrlkRpinpnpgfieqleqyefileall

subfamily_PTPN23_pd Subfamily PTPN23 670-913 3e-66 218.2 In-house 34-280 (288) alignment
Range on Protein: 670-913
Range on HMM: 34-280/288.0
GLAITFAKLpqNLDKNRYKDVLPYDTTRVLLQGN-EDYINASYVNMEIPAAnlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQY
. .|. |||  . .|||..|.|||| .|| |.|. .||||||.|.   | .    ..||||.||. | . ||..|..|| |.||||.. .|.|..|...|
krsiaiakl..yseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgc...PdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrY

WPDPPD-VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS-----LRVDSEPVLVHCSAGIGRTGV
||   .  ...| ... ..|.  |  .| |.. ..  .. . ..|.|||. .||..|||.  ...|.|.. |.|      |    |..||||||.|||||
wPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgv

LVTMETAMCLTE-RNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
.  . .|.  .| .|  .  ...|...| ||  |||...|.||. ||.|.  
falvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa

subfamily_PTPN1_pd Subfamily PTPN1 670-911 4.1e-65 214.4 In-house 21-269 (290) alignment
Range on Protein: 670-911
Range on HMM: 21-269/290.0
GLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ-GNEDYINASYVNMEipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQY
 . .. ||||.| ..|||.|| ||| .|. |. .. |||||| |..|    ..  .|| ||||||.|.. |||.||.||   .|||  . |....||.||
dfptreaklpenrnlnryrdvspydhsrikleradndyinaslvele....eakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPDPPD----VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSEPVLVHCSAGIGRTG
||   .    ....  ....  ||. .  |. | . ..| .| | ....|  |..||| |||.  . ||.|.  ||   ||  |  |...||||||||.|
wPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsG

VLVTMETAMCLTERNLPIYPLDIVR---KMRDQRAMMVQTSSQYKFVCEAILR
 .. ..| . | |..  .  .|| .   ..| .|  ..||  | .|   ||| 
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 671-914 8.6e-57 187.3 In-house 37-279 (287) alignment
Range on Protein: 671-914
Range on HMM: 37-279/287.0
LAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN-EDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYW
  .| .  .|| ||||....|..|  ||||.|. .|||||....    . .  ...|....|. .|  .||....|.. . ||||. ..|  . .|.|||
devthniasqnkdknRltqilvpdnyrvllkgehpdyinavfid....gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyW

PDPPDvMNHGGFHIQCQSEDCTIAYVSREMLVTNTQ-TGEEHTVTHLQYVAWPDHG-VPDDSSDFLEFVNYVRSLRV-DSEPVLVHCSAGIGRTGVLVTM
|.    .  | ..|.  .|. .  |. |.. |.|.. .|....|.  |. .|...| |..  . .| . . ... |     ...||||...||..... .
peeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaa

ETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE
.|..  ....  |  .......| |.  .||| .||||.....|   .
attinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 672-916 1.6e-75 248.9 In-house 38-283 (288) alignment
Range on Protein: 672-916
Range on HMM: 38-283/288.0
AITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVNMEipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCH
. | ..|..| .||||...|||| .|| |..     ..|||||||.. |    .  .|||||||||..|  .||..|...| | ||||| | |.|.|||.
svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge....kkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCe

QYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTntQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSAGIGRTGVLVT
.||||  .  |.| . .. ...  .  .| |..|.   ....| ..|..|| ||||||||... ..||... |      |..|..||||||.||||. ..
eYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFia

METAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE-EG
.....   |..  |  ...| |.| |||..||| .|| |. |..| . | .|
ldalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedg

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 672-913 2.2e-67 222.4 In-house 47-290 (298) alignment
Range on Protein: 672-913
Range on HMM: 47-290/298.0
AITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCH
  . |. |.| .|||| |....| .||.|.      . ||||||...    |..  | .||||.||..| ..||..|.... . |||||.|.| ..||.|
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh....aykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyh

QYWPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE--PVLVHCSAGIGRTGVLV
.||||     ..| .... .|..    ...|.. |..... .|..| .|... |||.|||  ..  |.... ||  . ..   ||.|.||||.||.|  .
kywPde.gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfi

TMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
 ... .   ...  .  ...|. .| .|. .||| .||.|. ||.|.. 
aidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 672-914 2e-53 176.0 In-house 27-278 (287) alignment
Range on Protein: 672-914
Range on HMM: 27-278/287.0
AITF--AKLPQNLDKNRYKDVLPYDTTRVLLQGN----EDYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKC
..||  |.   .  |||| ||||.| |||||  .     ||||| ||    .. .  ...||.|||.. |  .||..|.... . ....|   | .| ||
tatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyv....asytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkc

HQYWPDPPDVMNHGGFHIQCQSEDCT-IAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYV----RSLRVD--SEPVLVHCSAGIG
..|||..   |  ||. .   . |     |  | . . . .| | . |  |....|||....  .  .. ||  |       |      |..||...|||
ykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiG

RTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE
|.|.|... . .   |    . .  .| ..| .|| .||.  |.....||.   |.
rsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 672-753 2.9e-09 30.9 In-house 28-115 (347) alignment
Range on Protein: 672-753
Range on HMM: 28-115/347.0
AITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN----------EDYINASYVNMEipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVM
 .|...  ..|.||| |||   |.|||.|  .          | |||||.....    |  ..|| || |||.|  .||..|   |.. .| 
kftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfd....naskeyiltqyplpdtvrdfwkmvsvtkvtqvvt

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 672-764 4.1e-07 23.8 In-house 25-117 (332) alignment
Range on Protein: 672-764
Range on HMM: 25-117/332.0
AITFAKLPQNLDKNRYKDVLPYDTTRVLL---QGNEDYINASYVNMEipaaNLVNKYIATQGPL-PHTCAQFWQVVWDQKLSLIVMLTTLTERGRTK
  |. |. .|.| ||   .  .| .|| |   .|..|. |||.|.      .  . || .| |.  ||   ||..| ..| |.|...  . |. . |
pntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgy....skksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 673-911 5.1e-60 197.9 In-house 36-275 (315) alignment
Range on Protein: 673-911
Range on HMM: 36-275/315.0
ITFAKLPQNLDKNRYKDVLPYDTTRVLL-----QGNEDYINASYvnmeIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQ
 . |. ..|  |||||..||.|..|| |     . ..|||||||    |.. .  . |||.||||. .   ||..|...| . |||.| . |  . || |
qrvaretinfkknryknilPldsarvkleviddsPdsdyinasy....iksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPD-PPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNtqTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSAGIGRTGVLVT
||||   | .. | ....  | . .   | |.. . .  . | .|||  |.  |||.||. ..| .|...  |.. .  .  ..|||||||.|||||...
ywPdrkadsvefGsikvellsleadtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvis

METAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
..  .   .|.  .  ...|...|..|  .|||  .| |. .|.| 
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle

subfamily_PTPRN_pd Subfamily PTPRN 673-910 4.7e-54 178.1 In-house 48-289 (297) alignment
Range on Protein: 673-910
Range on HMM: 48-289/297.0
ITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVNMEIPAAnlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQ
 . || ..|..|||.|.||||| .|| |.      ..|||||| .  . | |     ||||||||..| |.|||.||.|   .||.||.|.| | ..|..
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdpra...payiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckr

YWPDPPDVMnHGGFHIQCQSEDCTI-AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYV-RSLRVDSEPVLVHCSAGIGRTGVLVT
||||    . .. . ..  ||      |. | . . | || |  ||| . ...||..|||  .  .|||   | .| |  | |..||||.| ||||| . 
ywpdeGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyil

MEtaMCLTERNLPIYPLDI---VRKMRDQRAMMVQTSSQYKFVCEAIL
..  . |.  .  .  .||   . ..||||. .|.| .|..|.  |. 
id..lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 673-912 5.8e-43 141.9 In-house 27-269 (285) alignment
Range on Protein: 673-912
Range on HMM: 27-269/285.0
ITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-NEDYINASYVNMeiPAANlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD
 |..    | | ||| ||   . |||.|.  . ||| ||.. |  |  .  . ||.|||||| | ..||......|.. ..|| || | |  ||  |.|.
ctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrm..pgkd.qstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

P-PDVMNHGGFHIQ---CQSEdCTIAYVSREMLVTNTQ--TGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVT
   .|.. | . |    |. | .    .   . |.||.  . |   . |.|   |||.  |.|.  ..|. ..|. .    .|. ||||||.|||  .| 
klgevvkfgkyeitlteckee.aiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvg

METAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV
.. |      |  |  |||||.||  |   ||.  |. |.   ..  
idyatirimenpniemldivremramrfqavqshmqflflyvvlmey

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 673-911 1.7e-42 140.2 In-house 37-234 (392) alignment
Range on Protein: 673-911
Range on HMM: 37-234/392.0
ITFAKLPQNLDKNRYKDVLPYDTTRVLL-----QGNEDYINASYvnmeIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGrtkchq
 | |. . || |||||..||||..|| |       ..||.||||    ||. .  . |||.||| . .  .||..|.... . |.|.| | |        
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasy....ipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

ywpdppdvmnhggfhiqcqsedctiayvsremlvtntQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD-SEPVLVHCSAGIGRTGVLVTM
                                     .  . .||.  ... |||..||  .| .|.|.. |..   . . |...|||||.|||||....
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisi

ETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
.. .. ...   .  ...| ..| .| .||||  || |.  |.| 
dsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 673-730 2e-07 25.1 In-house 40-95 (95) alignment
Range on Protein: 673-730
Range on HMM: 40-95/95.0
ITFAKLPQNLDKNRYKDVLPYDTTRVLLQG--NEDYINASYVNMEipaaNLVNKYIATQG
 |      |. |||. ...|||.||| |    . ||||| .|.         | |||.||
ytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgy....arkncyiaaqg

0042113 (Phosphotyrosine protein) phosphatases II 674-911 2.9e-80 264.5 In-house 2-241 (245) alignment
Range on Protein: 674-911
Range on HMM: 2-241/245.0
TFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE-----DYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQY
..|.|| | |||||.|.|||| ||| |.  .     ||||||||    .  .  .|.||||||||.|.. ||. .|..... |||||...|.|| ||.||
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyv....dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqy

WPDpPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV--DSEPVLVHCSAGIGRTGVLVTM
||.  .....|.|.... ||.    |. |.. |||....|...|.|..|. ||||||||.....|.|...||. .   ...|||||||||.||||.....
wpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa

ETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
 ..... |..| . . ..|...|.|| ..||| |||.|. ||.| 
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

0040439 (Phosphotyrosine protein) phosphatases II 674-911 8.4e-79 259.9 In-house 4-244 (249) alignment
Range on Protein: 674-911
Range on HMM: 4-244/249.0
TFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQY
..|.|| |.|||||.|.|||| .|| |.        |||||||.    .  .  ...||||||||.|.. ||. .|... . |||||.|.|.|| ||.||
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi....dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPDpPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV---DSEPVLVHCSAGIGRTGVLVT
||.  .....|.|.... |..    |. |.. .||...||..||.|.||. |||||||.. .|.|.|...||. .    ...|||||||||.||||....
wpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

METAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
. ..... |..| . ....|...|.|| ..||. .||.|..||.|.
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle

0037934 (Phosphotyrosine protein) phosphatases II 674-910 6.5e-76 250.3 In-house 3-239 (243) alignment
Range on Protein: 674-910
Range on HMM: 3-239/243.0
TFAKLPQNLDKNRYKDVLPYDTTRVLLQGnEDYINASYVNMEiPaanlvnKYIATQGPLPHTCAQ----FWQVVWDQKLSLIVMLTTLTERGRTKCHQYW
..|.||.||.||||.|.|||| .|| |.| .|||||.....  |      ..||||||||.|...    ||. .|... . |||||.|.|.|| ||.|||
siallpenlsknrysdilpydhsrvkleg.sdyinanliyvt.p......rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PdpPDVmNHGGFHIQCQSEDCTIAYVSREMLVTNTQ-TGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS---------LRVDSEPVLVHCSAGIGR
|   .| ..|.|.... ||  .  |. |..|..|.. ......|.|..|..||||||||. .|.|.|...||.          . ...|||||||||.||
p..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGVLVTMETAMCLTernlPIYPLDIVRKMRDQRAM-MVQTSSQYKFVCEAIL
||.|... . . |      . ....|...|.|| . .||| |||.|. ||.|
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall

subfamily_PTPRK_pd Subfamily PTPRK 674-911 5.8e-60 197.7 In-house 36-275 (314) alignment
Range on Protein: 674-911
Range on HMM: 36-275/314.0
TFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE-----DYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQY
  ||  .| .|||..|.|.|| .|| |.  .     |||||...     . .  ...|.|||||..| . ||..|.|.. . ||||| |.| || || .|
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaali....dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClky

WPDPPDVmnHGGFHIQCQSEDCTIAYVSREMLVTN--TQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE-PVLVHCSAGIGRTGVLVT
||.  .|  .| ..... . .    .|.| . |..   .  | ..| ..|...||||.||     .|..|  | . . ... ...|||||| ||||. ..
WPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfia

METAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
... . . ||.  .    .|...|...  ||.|  ||||. ..|| 
idivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 674-911 1.4e-57 190.1 In-house 44-282 (297) alignment
Range on Protein: 674-911
Range on HMM: 44-282/297.0
TFAKLPQNLDKNRYKDVLPYDTTRVLLQG--NE---DYINASYVNMEIPaanlvnKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRtKCHQY
| |.   |..|.|||..||||. || |.   ..   ||.|||.|.          ..|.|| | . | | ||..|.|.. | ||||. . || . || .|
tvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh......rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcary

WPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPD--DSSDFLEFVNYVRSL-RVDSE-PVLVHCSAGIGRTGVLV
|.|   |.. |   .. .| .    .. ||. ||. ..  .. |   |.| |||. |.   . | .|.... ||      .| |.||||.||.||||||.
Wsdk.gvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll

TMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
|..  ..  .|.  .  ...|.|.|..|  .|||  ||||| .|.| 
tidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavle

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 674-773 4e-10 33.7 In-house 89-182 (244) alignment
Range on Protein: 674-773
Range on HMM: 89-182/244.0
TFAKLPQNLDKNRYKDVLPYDTTRVLLQG---NEDYINASYVNMEIPAAnlvnKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERgrtkcHQYWP
  |  |.|  |||    ||.|  || |      . |||||.|     .|    .|| || ||  |  .||... .... ..|.| .. |       .|||
kdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrta....eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywp

DPP
|  
dse

subfamily_PTPRA_pd Subfamily PTPRA 675-916 2.5e-62 205.7 In-house 52-298 (330) alignment
Range on Protein: 675-916
Range on HMM: 52-298/330.0
FAKLPQNLDKNRYKDVLPYDTTRVLLQ---G--NEDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYW
 |.  .| .|||. ..|||| .|| |.   |  . ||||||...      .  .|.||.|||. .|   ||...|.|| . ||||| | || ..||.|||
laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfid....GykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVT----NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSAGIGRTGVLV
||   .. .|  ... . |  ...|  |..||.    .|.  ..  |. . . .||| ||| ..   |.... |..|. . ..|. ||||||.|||| ..
Pde.GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfi

TMETAM--CLTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEG
.... .    .|| . ..  ..|...| ||. ||||  ||.|. ...|  |  |
vldavlervkaerkvdvf..efvkrlrlqrpqmvqtdeqyefiykvlleyylyg

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 675-713 6.8e-06 19.7 In-house 41-84 (440) alignment
Range on Protein: 675-713
Range on HMM: 41-84/440.0
FAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVN
 | ||.|  ||||...| || .||.|.      ..|||||||.|
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 676-912 4.7e-62 204.4 In-house 4-241 (250) alignment
Range on Protein: 676-912
Range on HMM: 4-241/250.0
AKLPQNLDKNRYKDVLPYDTTRVLLQGNE-----DYINASYVNMEIPAanlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTkCHQYWP
|| |||..|||| |....| .||.|. ..     ||||||...         . .|||||||..|  .||..|...| . |||||.|.| ..| .|||||
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder....kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP

-DPPdvMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR--VDSEPVLVHCSAGIGRTGVLVTME
 . .   ..|. ...  |..    |..|.. .....  .| .| .|..|.||| |||.     ||... |.. .  ... ||.|.||||.||.|  ....
veka..ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaid

TAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV
. .   ...  .   ......| .|  .|.. .|| || |.||. 
avlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 676-915 4e-36 119.3 In-house 47-284 (301) alignment
Range on Protein: 676-915
Range on HMM: 47-284/301.0
AKLPQnlDKNRYKDV--LPYDTTRVLLQGNEDYINASYVNMEipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP-DP
| ||.  ||.||. |   |  . .|. .|.   | | ... .       ...|||||||. |.  || ..   ..  ||||.   |.  .||..| | ..
aylpk..dkhryptvPckPstavevivdGkrvPihanwipts....GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvki

PDVMNHGGFHIQCQSEDCTIA--YVSREMLVTNT-QTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSlrvDSEPVLVHCSAGIGRTGVLVTMETA
.. .. | |.|. ....  .    . |.. |... .  . .|||| ||. |.|.|||    .  .... |.      .|..|||||||||.  ... |  
sekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk...sekPivvhcsaGiGrsvafigteyl

MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFV-CEAILRVYEE
    | .  |   . ....|..|   ||| ||  ..   .. |.  |
areveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlike

subfamily_egg_pd Subfamily egg 676-913 1.9e-31 103.9 In-house 35-270 (307) alignment
Range on Protein: 676-913
Range on HMM: 35-270/307.0
AKLPQNLDKNRYKDVLPYDTTRVLLQGN-----EDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERgrTKCHQYWP
|    ||.| | | |   |..|| |. .     .|.| | .|.       |.|..| .| ||  |  .||..|. ..   |||||.  |    .|. |||
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvk....Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

DPP-D--VMNHGGFHIQCQSEDCT---IAYVSREMLVTNTqtGEEHTVTHLQYvawpDHgvpDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLV
  . |  |.  |...|..   | .   .  |..  ||      ||  . | |.    |    . |||    .. .| ||  |.||.|..  |. ....||
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqg....dv...nnssdvysplrvlrklrnlskpvvvqdilGvskaatlv

TMETAMCLTERNlPIYPLDIVRK---MRDQRAMMVQTSSQYKFVCEAILRVY
..|.|..   |  ||.   . |    .| .| . |..  .| ||   .| ..
aieiallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfff

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 677-911 8.5e-62 203.7 In-house 24-266 (274) alignment
Range on Protein: 677-911
Range on HMM: 24-266/274.0
KLPQNLDKNRYKDVLPYDTTRVLLQG------NEDYINASYVNMeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP
... .  |||||..|| ...||||.       . .|||| |.       .  . |.|||||||.| |.||.... .. ..||||| |.|. ..||..|.|
dvfgsqtknryktilPnensrvllesessededssyinanyikG...ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

DPPDV---MNHGGFHIQCQSEDCTIAYVSREMLVTNTQTgeEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDS----EPVLVHCSAGIGRTGVL
|  |.    ..|...|. ..   .  |  |.... ...   |..|.|  | .|||| .||| . .|..|. |.. | ..     ||.|||||||||||. 
daedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcf

VTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
.... |.   ...  .  | || ..| .|  |||||.||... .|.  
iaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 677-915 1e-41 137.7 In-house 44-289 (305) alignment
Range on Protein: 677-915
Range on HMM: 44-289/305.0
KLPQNLDKNRYKDVLPYDTTRVLLQGN--EDYINASYVNMeiPAAnlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD-PP
|  |. .|||||||   |  || |.|    .|| | ||    |.    ...| || || .|||.|| . ...|.  | ||  | |.|  ||..|..    
keaqeagknrykdvgcldnnrvklegpwpheyihanyvst..ptn..pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdk

DVMN--HGGFHIQCQSE--------DCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRslrVDSEPVLVHCSAGIGRTGVL
||..   .| .|. . |        . . | |.. .|| .   .. . |||  .. ||| |||      ||...  |   .   |. ||||||||||| .
dvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar...pskgpivvhcsagigrtgsv

VTMETAMC-LTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE
| .|  .  | . .       |..|.|.||   .||  || || . ||  ...
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 678-910 1e-40 134.4 In-house 5-238 (239) alignment
Range on Protein: 678-910
Range on HMM: 5-238/239.0
LPQNLDKNRYKDVLPYDTTRVLLQ-----GNEDYINASYVNMEIPAanlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDP
   |  |||| ... || .||.|.        |||||||.     .    . |||||| .  .. .||...|...  .||||| | |  . |||||||| 
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgs...pkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

pdVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS-LRVDSEPVLVHCSAGIGRTGVLVTMETAMC
    ..  ...  .  .    |. | .....    ||. | . ..  |||.|||. ..  | .   .       . | ..|||||.|||| .. ... . 
..tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

LTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL
 ....  .  .. |. .|..|  ||||| || |.  |.|
qakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_CG7180_pd Subfamily CG7180 679-912 4e-42 138.9 In-house 40-289 (296) alignment
Range on Protein: 679-912
Range on HMM: 40-289/296.0
PQNLDKNRYKDVLPYDTTRVLLQ---G--NEDYINASYVNMEIPAanlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRtKCHQYWPDPP
 .|..|||. .|.||| .||.|.   |  ..|||||.||.  .      ..|| |..|  .|  .||..|.|.. | .|.||  ..  . ....|||   
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkk....keyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks

dVMNHGGFHIQCQSEDCTIAYVSREMLVTNT----------QTGEEHTVTHLQYVAWPD-HGVPDDSSDFLEFVNYVRSLRVDS------EPVLVHCSAG
   ..| . ..  .|.   . ..|.. .| .           . |. .|...|.  |.  . ||  .. ..|... ||..|         .||.|..| |
.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdG

IGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV
 .|.|| .... .. | |..  .   . |...| .|  .|..  .||.. . .|  
asRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 679-910 8.6e-41 134.6 In-house 5-237 (239) alignment
Range on Protein: 679-910
Range on HMM: 5-237/239.0
PQNLDKNRYKDVLPYDTTRVLLQ-----GNEDYINASYVNMEIPAanlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPp
  |  |||| ... || .||.|.        |||||||.     .    . |||||| .  .. .||...|...  .||||| | |  . ||||||||  
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgs...pkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.

dVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS-LRVDSEPVLVHCSAGIGRTGVLVTMETAMCL
   ..  ...  .  .    |. | .....    ||. | . ..  |||.|||. ..  | .   .       . | ..|||||.|||| .. ... .  
.tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

TERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL
....  .  .. |. .|..|  ||||| || |.  |.|
akkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 680-910 7.4e-50 164.4 In-house 2-236 (237) alignment
Range on Protein: 680-910
Range on HMM: 2-236/237.0
QNLDKNRYKDVLPYDTTRVLLQG---NEDYINASYVNMeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVM
.|  |||| ..  || .||.|.|   . |||||.|..         .||||.||||  .| .|||.||..| |.||||| | |. . |||.|||.  .  
enkiknrygnivaydhsrvvlkgagsgsdyinatylkg...fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa

NHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTV-THLQYVAWPDHGVPDDSSDFLEFVNYV--RSLR-VDSEPVLVHCSAGIGRTGVLVTMETAMCL
 .| . .  . ..    |  | .|... .| .|  .    |. .|||.|||. .. .| |   .  ||    .| | ..|||||.||||... ... .  
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

TERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL
.. .  .   . |  . ..|  ..||  || |. ..||
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 680-910 1.6e-33 111.0 In-house 42-268 (288) alignment
Range on Protein: 680-910
Range on HMM: 42-268/288.0
QNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVnmeIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDP-PDVMNH
.|  ..||...   |.||| |. . |.  |. |   ...|.  .. | .| ||  |  ..|... .. .  ||||. | |.|. |  .|.|    . .  
anptrdryenlprcditrvklsddpdfyiaanv...vssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHT-VTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLrvdSEPVLVHCSAGIGRTGVLV--TMETAMCLTER
| .  . . .   |  . .  |. ....|||.  | .| .  |.|.|||..   .| ... ..||    .|..||.|||.|||| |.   .   .   . 
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlksl...qkPivvhssaGvGrtgtlililialeslrldd

NLPIYPLdiVRKMRDQRAMMVQTSSQYKFVCEAIL
.| | .|  . |.|..|   .||  || .|   .|
flgirsl..laklreerfkaiqtemqylyvhrcvl

subfamily_ptpA1_pd Subfamily ptpA1 680-868 2.7e-32 107.0 In-house 46-251 (418) alignment
Range on Protein: 680-868
Range on HMM: 46-251/418.0
QNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPD-----
.|  |||| ..|| . ||| |.  .|   . |.| .       ...|.|||||| | |.||..||...  .||||.  .|  | || .|||.        
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

VMNHGGFHIQCQSED--CTIAYVSREMLVTN---TQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR---V----DSEPVLVHCSAGIGRTGV
.   |   .   | .    |    ||..  |   |  || . .|. ||  |||| .|| .  | ...  .   .   .       |..||||||.|||| 
iygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgt

LVTMET
..|   
fctavi

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 680-919 4.5e-30 99.6 In-house 32-264 (267) alignment
Range on Protein: 680-919
Range on HMM: 32-264/267.0
QNLDKNRYKDVLPYDTTRVLLQG-NEDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLterGRTKCHQYWPDP-PDVMN
.| ..||. |.|||| ||| |.  .|.|||||||.    . .  |..|.||.||  | ..|..|. |||.. ||.||.    .  . ...||    .  .
knqernrlddnlpyddtrvilrtkeeeyinasyve....gyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakk

HGGFHIQCQ--SEDCTIAYVSREMLVTNTqtgEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMC--LT
.  . ..     |.     .. |. . |      | ||   |  |            |  .     |   . |..|.||.|.||.| ...... .    |
yqdltvehslekeendyqiitlelkfkne...sahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerakt

ERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAiLRVYEEGLVQ
|  . |.  | .||.|.||  .|.|  .| .. |  |  | || ..
egvsdif..dflrkirsqriglvdtkeryiyihel.laeyaegrlk

Y_phosphatase Protein-tyrosine phosphatase 681-910 6e-81 266.7 Pfam-A 1-234 (235) alignment
Range on Protein: 681-910
Range on HMM: 1-234/235.0
NLDKNRYKDVLPYDTTRVLL---QGNEDYINASYVNMEIPaanlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP-DPPDVM
|..||||||.|||| ||| |   .|..|||||.||..        .|.|||||||..|...||..||..| ..|||||.|.|.||.||.|||| .  . .
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke....kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

NHGGFHIQCQ--SEDCTIAYVSREMLVTNTQTG-EEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSAGIGRTGVLVTMETAMCL
..| ......  ... . .|. |.. ......  |...|..|.| .|||||||......|.... |.. .  .|.||.||||||.||||..|....... 
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

TERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL
 |..  .  |.||...| ||..|||. .||.|...|||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 681-910 6e-81 266.7 In-house 1-234 (235) alignment
Range on Protein: 681-910
Range on HMM: 1-234/235.0
NLDKNRYKDVLPYDTTRVLL---QGNEDYINASYVNMEIPaanlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP-DPPDVM
|..||||||.|||| ||| |   .|..|||||.||..        .|.|||||||..|...||..||..| ..|||||.|.|.||.||.|||| .  . .
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke....kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

NHGGFHIQCQ--SEDCTIAYVSREMLVTNTQTG-EEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSAGIGRTGVLVTMETAMCL
..| ......  ... . .|. |.. ......  |...|..|.| .|||||||......|.... |.. .  .|.||.||||||.||||..|....... 
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

TERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL
 |..  .  |.||...| ||..|||. .||.|...|||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 681-911 8.5e-61 200.3 In-house 20-262 (270) alignment
Range on Protein: 681-911
Range on HMM: 20-262/270.0
NLDKNRYKDVLPYDTTRVLLQGN-----EDYINASYVNmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDV
.   |||.|.||  .||| |.         |||| ||.    . .  .||||..|||| |  .||...|..| . |||.| |.|.||.|| .|||  |. 
gkklnRyadiLPsPatRvrleeleedsataYinAnyvr...GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

---MNHGGFHIQCQSEDCTIAYVSREMLVTntQTGEEHTVTHLQYVAWPDHGVPDDSS------DFLEFVNYVRSLRVDS---EPVLVHCSAGIGRTGVL
   ...|  ..  .||  .  |. ... ..  ..|||. ..| .|..||||||| ..       . |. .. ||  . .    ||.|||||||.||||.|
kvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

VTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
.....|..| |..  . .| |....| .|  .||.. ||.|. .|.. 
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 681-911 4.2e-52 171.6 In-house 56-281 (290) alignment
Range on Protein: 681-911
Range on HMM: 56-281/290.0
NLDKNRYKDVLPYDTTRVLLQ--GNEDYINASYVNmeipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDP-PDVMN
.. |||||||   | |||.|.  .. ||. | ||.       |   .| |||.|  |  ..|..| ..| . ||||  | | |..||.||.|.   .|. 
efkknrykdvvcndktrvilkdGydGdyvhanyvk......GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

HGGFHIQCQSEDCTIAYVSREML-VTNTQTGEEHTVTHLQYVAWPDHGVPDDSsdfLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAM-CLTEr
 | . . |  ||   | . . .| | . ..| || . ||. ..|||. |.  .   | ..  .|.||  | || ||||||||||| .|..|... .|.. 
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst...lallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilld.

NLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
   . .||.|| .|. |.  ||   ||  . |..| 
Gkeldlldlvralrnsrlnsvqvdiqylalveilld

0041856 (Phosphotyrosine protein) phosphatases II 681-914 1.1e-51 170.4 In-house 1-172 (182) alignment
Range on Protein: 681-914
Range on HMM: 1-172/182.0
NLDKNRYKDVLPYDTTRvllqgNEDYINASYVNMEIPAANlvnkYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTtltergrtkCHQYWPdppdvmnhgg
|||||||.|.|||| .|     . |||||... .  || .    .|||||||..|.|.|.. ..... ..||.||         ...|||          
nldknrysdilpydhsr.....dldyInanlylgslpatr....fiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

fhiqcqsedctiayvsremlvtntqTGEEHTVTHLQYVAWPDHGVPDdSSDFLEFVNYVRSlrvDSEPVLVHCSAGIGRTGVLVTMETAMCLternlPIY
                         . .|.......|. ||||||||  ...|.|.. |..   ...|||||||||.||||.|| .   ..|      . 
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle...eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvs

PLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE
. ..|. .| .| .||.| .|| |.  |.| ...
leeavklvrsrRpgmvitpnqyfflqlallelll

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 681-914 5.6e-40 131.9 In-house 55-290 (305) alignment
Range on Protein: 681-914
Range on HMM: 55-290/305.0
NLDKNRYKDVLPYDTTRVLLQG--NEDYINASYVNMEIPAAnlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPP--DVM
.  ||||.||   | . |.|.     ||| | ||   .      ...|..|||| .|  .|| .| ..|.  ||||    | |. || ||||      . 
aitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipe...krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

NHGGFHIQCQSEDCTIAY---VSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVdsePVLVHCSAGIGRTGVLVTMETAMCLT
 ..|  ..  |    .     .   .|  .   ... .| |||.  ||| |||      ||..  .|  .|   |..||||||||||| .|..|  .   
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv...pivvhcsagigrtgtivaieyileki

ERNLPIYPL-DIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE
  | |  |. ..|. .|||||. .|.  || |.   .|  . 
aenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl

subfamily_CG42327_pd Subfamily CG42327 681-840 8e-23 75.6 In-house 28-191 (319) alignment
Range on Protein: 681-840
Range on HMM: 28-191/319.0
NLDKNRYKDVLPYDTTRVLLQGN-----EDYINASYVNMEIPAanlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDV
  ||.|. .|.|   ||| ||       . |..||||     |    | |||.| .|  . ..||..||.|.   || || | | |  .| .|.|     
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGydda...pnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

M---NHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYvAWPDHGVPDDSSDFLEFVNYVR
     .| . .  .  .    |.   .|. . .  |   .||  |  |.. .|| . . ..  .  ||
dntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 682-771 5.9e-26 86.0 In-house 48-152 (350) alignment
Range on Protein: 682-771
Range on HMM: 48-152/350.0
LDKNRYKDVLPYDTTRVLLQ-------------GNEDYINASYVNMEIPAANLVN--KYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCH
  |||||..|||. .|| |.               .|||||.|.... .. .     ||||||.||| |  .|..|.   |  .|..||.. | .. ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPD
.||..
rYWqe

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 683-917 3.5e-32 106.4 In-house 45-281 (312) alignment
Range on Protein: 683-917
Range on HMM: 45-281/312.0
DKNRYKDVLPYDTTRVLLQGNED-YINASYVNMeipaANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGF
| ||| ..  .|  |  | |.|. || | .|..        .....|||||  ||..|||..     . |..|... | |  || .|  |    ..    
dlnrypniqcwdrgrftlagdenfyihanfvki....ctkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

HIQcqSEDCT---IAY------VSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNyvrSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCL
 .   .| ||   |          | . |    ||.|  . | |. .|||||.||     | ..    ... |  ||. |||||.|||| |. .|. .. 
rvy..teycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrlls...avkkdkkpviahcsagvgrtgtlaliesmiaa

TERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR-VYEEGL
          |.   .| .||  |..  || ..  ..|  .| .||
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 691-825 6.2e-09 30.3 In-house 3-126 (130) alignment
Range on Protein: 691-825
Range on HMM: 3-126/130.0
LPYDTTRVLlqgNEDYINASYVNMeipaANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERgrtkcHQYWPDPPDVMNHGGFHIQCQSEDC
|... .|.    ...|||||.| .     .  ..|. || ||  |. .||... .. . ..|.| .. |       .||||   .  .    |   ..  
lefevsrlq...gntyinasfvGl....lgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrd

TIAYVSREMLVTNTQTGEEH-TVTHLQYVAWPDHGV
   ..  . |  . .  | | ..| .|   ||  | 
efknikasnleiesdlneshqaltmfqisnwpsdgt

0044763 (Phosphotyrosine protein) phosphatases II 692-914 3.8e-36 119.8 In-house 1-172 (178) alignment
Range on Protein: 692-914
Range on HMM: 1-172/178.0
PYDTTRVLLQGNED-----YINASYVNmeipaANlvnKYIATQGPlphtcAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDvmnhggfhiqcq
|.| |||||.  |.     |||||..       .    |.....|     |.... ........||.||. .|.|. ||..|||.  .            
pldrtrvllsnleglersdyinaseil.....pg...lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag............

sedctiayvsremlvtntqtgeehtvTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSAGIGRTGVLVTMETAMCLternlPIYPLDIV
                           . ... .||||||| .. |||||.......  . .|||||||||.||.|.|| .   ..|      . . ...
..........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeai

RKMRDQRAmMVQTSSQYKFVCEAILRVYE
. .| .|  .|.. .|.....|  ||...
elvrerRp.ivpnpgqlrqLyefelrllk

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 696-910 5.2e-27 89.7 In-house 33-256 (290) alignment
Range on Protein: 696-910
Range on HMM: 33-256/290.0
TRVLLQG-----NEDYINASYVNMeiPaANLvnKYIATQGPLPHT-------CAQFWQVVWDQKLSLIVMLTTLTERGRT----KCHQYWPDPPD-VMNH
||| |.|     |.||| |..| .  |  .|  . |.|| |. ..         .|| .. . |   .|||   .|. .      | .| |.  .  .. 
trvvLkgygkrfnddyiHAnrvtc..p.ngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkf

GGFHIQCQSEDCTIAYVSREMLVTnTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRslrVDSEPVLVHCSAGIGRTGVLVTMETAMCLT-ERNL
.|. ..|.|         ||..|.  . .||.|||| ... | .  |..|.  .|. ...|.       ||.|||  || |  .| ... .. .  | . 
kgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvk...asktpvivHcvdGiSrsAalaaiilgyQkiaetsg

PIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL
 .   |.. ..| |||.....  .. ||  .|.
svkledvlkalrkqralaitsalelafvdagiv

0046846 (Phosphotyrosine protein) phosphatases II 700-912 5.9e-46 151.7 In-house 8-172 (176) alignment
Range on Protein: 700-912
Range on HMM: 8-172/176.0
LQGNEDYINASYVNMEipaanlvnKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDppdVMNHGGfhiqcqsedctiayvsrem
|... |||||... .         ..||||||||.|.|.|.. ..... ...|.||...| || ||..|||.   ....|                    
ldldldyinanlilgs........rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi...................

lvtntqtgeehtvtHLQYVAWPDHGVPDDsSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMEtamcLTERNLPIYPLDIVRKMRDQRA-MMVQT
              . ... ||||||||. ...||.....|. . . .||||||||||||||.|| .     | |..  . ........|.||  ..|||
..............qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt

SSQYKFVCEAILRV
 .||.|. |..|..
peQyrflyefelll

0043147 (Phosphotyrosine protein) phosphatases II 703-906 5.7e-46 151.7 In-house 4-154 (172) alignment
Range on Protein: 703-906
Range on HMM: 4-154/172.0
NEDYINASYVNMEIpaanLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLtergrtkchqywpdppdvmnhggfhiqcqsedctiayvsremlvT
..|||||||... .      ...|||||||..|.|.||. ..... ..||.||.|                                            .
gsdyinasyldlyy....ipdrfiatqgplrntladfwrmlkelgithivnltel............................................l

NTQTGEEHTVTHLQYVAWPDHGVPdDSSDFLEFVNYVRS--LRVDSEPVLVHCSAGIGRTGVLVTMETAMclternLPIYPLDIVRKMRDQRAMMVQTSS
.. ...|... ...|. ||||||| ... .|||......  .. ...|||||||||.||||.|| .   .      | . ....|. .|..| ..||. |
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYKFVC
||.|..
qyrfly

0051429 (Phosphotyrosine protein) phosphatases II 704-914 1.9e-53 177.2 In-house 4-226 (272) alignment
Range on Protein: 704-914
Range on HMM: 4-226/272.0
EDYINASYVNMEiPAANLVNKYIATQGPLPHTCAQFWQVvWDQKLSLIVMLTTLTERGRTKCHQYWP-----------DPPDVMNHGGFHIQCQSEDCTI
..||||..|..      . .......||||.|.|.||.  ...... ||.|....|||| ||..|||           | .  ...| ... ..|| .. 
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

AYVSREMLVTNT-QTGEEHTVTHLQYVAWPDHGVPDDSsdFLEFVNYVRSlrvdSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIY--------PLD
 |. ||.|.|.. ..|| ..|.||.| .|||||||...  .||.......    ..|||||||||..|||..| .   .   ...  .         ...
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

IVRKMRDQRAMMVQTSSQYKFVCEAILRVYE
.|...|.||. .|||  ||.|..||.| ...
aveelraqrpgavqteeqylflyeallellr

0036282 (Phosphotyrosine protein) phosphatases II 704-906 5.3e-47 155.0 In-house 2-163 (174) alignment
Range on Protein: 704-906
Range on HMM: 2-163/174.0
EDYINASYVNMEIPAAnlvnKYIATQGPLPhtcaqFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDppdvmnhggfhiqcqsedctiayvsremlvtn
.||||||.... .       ..||.||||.     ||. ....... .|||... |.|..||..|||.                                
sdyinaspldlsyitp....rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................

TQTGEEHTVTHLQYVAWPDHGVPDDSSdFLEFVNYVRSLRVD--SEPVLVHCSAGIGRTGVLVTMETAMCLTErNLPIYPLDIVRKMRDQRAMMVQTSSQ
... .|... ...|. ||||||||.|  .||||..|.. . .  . |||||||||.||||.|| .   ... . . ..  ||.||..| || .|||| ||
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YKFVC
|.|. 
yrfly

0051082 (Phosphotyrosine protein) phosphatases II 704-908 2.3e-33 110.3 In-house 3-148 (151) alignment
Range on Protein: 704-908
Range on HMM: 3-148/151.0
EDYINASYVNmeiPAanlvnkYIATQGPLPhtcaQFWQVVWDQKLSLIVMLTTLTERGrtKCHQYWPDPPdvmnhggfhiqcqsedctiayvsremlvtn
.||||.|||    .       .....|||.    .|.. ....... ||.|....|||  .|..|.|.                                
sdyinfsyvt...gg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..............................

tqtgeeHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSlrVDSEPVLVHCSAGIGRTGVLVTMETAMcLTernlpIYPLDIVRKMRDQRAMMVQTSSQYK
      ..|.|.... |||.|.|.    .|||......   .. |||||||||.||||.|| .   . |      . . .... .| .| ..||.. |. 
......ievlhipildwpdpglplsfdavleflellld..kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqfl

FVCEA
|.  |
fqlfa

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 704-795 3.7e-14 46.8 In-house 90-175 (349) alignment
Range on Protein: 704-795
Range on HMM: 90-175/349.0
EDYINASYVNmeIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDppdvMNHGGFHIQCQSEDCTIAYV
.||||| |..  ..  .  .|||||| ||| |   |..|.  ... |.. |.   | .  ||..|| .    ... ..... |     || |
ddyinanylk..ltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe....lsysnitvklqnsslyianv

0049260 (Phosphotyrosine protein) phosphatases II 721-906 1.6e-41 136.8 In-house 7-143 (152) alignment
Range on Protein: 721-906
Range on HMM: 7-143/152.0
LVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWpdppdvmnhggfhiqcqsedctiayvsremlvtntqtgeehtvtHLQYVAW
  ...||||||.|.|.|.||. ..... . |||||.|.|.|. ||.||.                                            . ... |
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpw

PDHGVPDDSSDFLEFVNYVRS-LRVDSEPVLVHCSAGIGRTGVLVTMETAMclternLPIYPLDIVRKMRDQRAMMVQTSSQYKFVC
|||||||.|  .|...  ..  .. ...|||||||||.||||.|| .   .      | . ....|. .| .| ..|.. .|..|. 
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 723-905 2.6e-17 57.6 In-house 4-195 (198) alignment
Range on Protein: 723-905
Range on HMM: 4-195/198.0
NKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPD-VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEH--TVTHLQYVA
 .||||| || .| |.|||.||.     |||.        .    |||     . ..| . . ...  .   |.   ...||  |       ..| |. .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDdSSDFLEFVNYVRSLRVD-----SEPVLVHCSAGIGRTGVLVTMETAMCLTERN-LP-IYPLDIVRKMRDQRAMMVQTSSQYKFV
| ..  |.  . |. ||   | .          ||.|||| | | |||.|...  .   |      .  ... ...|. |  .. .  .|.|.
wkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 723-905 2.7e-17 57.6 In-house 5-196 (199) alignment
Range on Protein: 723-905
Range on HMM: 5-196/199.0
NKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPD-VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEH--TVTHLQYVA
 .||||| || .| |.|||.||.     |||.        .    |||     . ..| . . ...  .   |.   ...||  |       ..| |. .
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDdSSDFLEFVNYVRSLRVD-----SEPVLVHCSAGIGRTGVLVTMETAMCLTERN-LP-IYPLDIVRKMRDQRAMMVQTSSQYKFV
| ..  |.  . |. ||   | .          ||.|||| | | |||.|...  .   |      .  ... ...|. |  .. .  .|.|.
wkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 723-783 2.2e-08 27.8 In-house 236-293 (440) alignment
Range on Protein: 723-783
Range on HMM: 236-293/440.0
NKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERgrtKCHQYWPDPPDVMNHGGFHI
| .|||| ||  |  .||..| | ..| |.||  | ..    |  |||     .  | | .
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftv

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 727-907 6.8e-21 69.5 In-house 39-215 (255) alignment
Range on Protein: 727-907
Range on HMM: 39-215/255.0
AtqgplphTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVM-NHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGV
        | ..|.|..  .| . .|||. ..| |. ||..|.|   |         . .      .    .|.. | ..  . |||.| .|  |...  
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PDDSSDFLEFVNYVRslrvDSEPVLVHCSAGIGRTGVLVTMETAMC---LTER---NLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE
|... . |. .  ||    || .|.||||.||||.  .| .| .     .. .      .  | .....| .|.  ..|  |  |   
Pelareilnilkvvr....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsil

subfamily_hpo-7_pd Subfamily hpo-7 727-905 8.5e-18 59.2 In-house 42-219 (263) alignment
Range on Protein: 727-905
Range on HMM: 42-219/263.0
AtqgpLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVM-NHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGV
     |  | ..|.| .  .| . .|||.  .| |. || .|.|   |         . .      .   ..|.| |  .  . |||.| .|. |...  
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWieknd

PDDSSDFLEFVNYVRslrvDSEPVLVHCSAGIGRTGVLVTMETAMCLTER------NLPIYPLDIVRKMRDQRAMMVQTSSQYKFV
| .. . |. .. .|    .| .. ||||.||||.   . .|..     |         .  | .....| .|.  ..|  |  | 
pelareilnilkvar....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafs

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 730-906 8.4e-23 75.3 In-house 98-281 (302) alignment
Range on Protein: 730-906
Range on HMM: 98-281/302.0
GPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDP-PDVMNHGGFHIQCQSEDCTIAYVS-------REMLVTNT--QTGEEHTVTHLQYVA
 |   |. ..| .. . . ...| |... | .  || .|. |   .... | . ..  | .  ..  .         . ..|.  ..  ..||  |.. |
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPDDSSDFLEFVNYVRSLRVDsepVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVC
||||| |...   |. ...  | . .   ||||||||.|||| ||..   . |  ..     |.||  .|. |   ||. .|  .. 
wpdhGapkeaytaldilkfcesykkn...vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll

0048179 (Phosphotyrosine protein) phosphatases II 781-907 9.7e-26 85.6 In-house 31-139 (144) alignment
Range on Protein: 781-907
Range on HMM: 31-139/144.0
FHIQCQSEDCTIAYVSREmlvtntqtgeehtVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMcltERNlpIY
 .. . .|..  ... ||             ....... ||||||||.....|||........ ...|||||||||.||||.||..   .   ...  . 
ttvinlteeyepeflere.............giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk...klg..ls

PLDIVRKMRDQRAMMVQTSSQYKFVCE
. .... .| .| ..|.. .|..|..|
leealalvrsrrpgavpnpgqlrfLle

0048076 (Phosphotyrosine protein) phosphatases II 795-911 4.1e-28 93.3 In-house 36-141 (145) alignment
Range on Protein: 795-911
Range on HMM: 36-141/145.0
VsremlvTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMClternLPIYPLDIVRKMRDQRAM
.      |......|.......|. ||||||||.....|||........ . .|||||||||.||||.|| .   ..     | . . ......| || .
l......tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpg

MVQTSSQYKFVCEAILR
.|.. .|..|..|..|.
avpnpgqlrflyefele

subfamily_PTPMT1_pd Subfamily PTPMT1 799-892 8.4e-07 23.6 In-house 61-151 (171) alignment
Range on Protein: 799-892
Range on HMM: 61-151/171.0
MLVTNTQTGEEHTVTHLQYvAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTmetAM-CLTERNLPIYPLDIVRKMRDQR
.|. .|.. ... |..||. | .|.    |  . .. |..... . . . | ||| || ||.. ||.   .   ..|.  |   |....| |.. 
alansteewkklgveqlql.atvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlva...cylmkkeklspeeAlkalkkkRkii

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 801-912 9.7e-13 42.5 In-house 207-343 (350) alignment
Range on Protein: 801-912
Range on HMM: 207-343/350.0
VTNTQTgEEHTVTHLQYVAWPDHGVPDDSSDFLEFVN-----------YVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMC-------LTERNLPIY--
.| . . . . | .||.  |.| ..  .  ..|. ..              .    |.|.|||||||.||||.|||..  .        ||..   .   
itlaas.dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldva

--P----LDIVRKMRDQRAMMVQTSSQYKFVCEAILRV
         || ..| ||  |||.  |. |. ||.|  
aktrDlisiivnelrkqrismvqnldqfifiYeallfy

PTPc_motif_SM00404 807-878 5.4e-07 24.6 In-house 42-109 (140) alignment
Range on Protein: 807-878
Range on HMM: 42-109/140.0
GEEHTVTHLQYVaWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMEtamCLTERNLP
 |.  ...||.    |... . | .. . ...... . . . ||||| ||. |.. |....   ....|.| 
kensgfqilqip.lddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY...lmryrqls

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 808-912 1.6e-17 58.0 In-house 87-193 (440) alignment
Range on Protein: 808-912
Range on HMM: 87-193/440.0
EEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSL--RVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFV
| .|. . .| .|||.|||  ..  |.... |     .. . |.||||||| |||||...... .  ..|.  |  . ..  ||..|  ||||  || ||
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

CEAILRV
 ||.|  
heavleg

DSPc Dual specificity phosphatase, catalytic domain 809-865 9.1e-08 27.0 Pfam-A 37-92 (133) alignment
Range on Protein: 809-865
Range on HMM: 37-92/133.0
EHTVTHLQYVaWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVT
.   ..|..    |.   . |... | |....... . . ||||| ||| |.. |..
kseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii

DSPc Dual specificity phosphatase, catalytic domain 809-865 9.1e-08 27.0 In-house 37-92 (133) alignment
Range on Protein: 809-865
Range on HMM: 37-92/133.0
EHTVTHLQYVaWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVT
.   ..|..    |.   . |... | |....... . . ||||| ||| |.. |..
kseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii

PTPc_DSPc_SM00012 811-910 1e-32 107.8 In-house 1-104 (105) alignment
Range on Protein: 811-910
Range on HMM: 1-104/105.0
TVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDS---EPVLVHCSAGIGRTGVLVTMETAMCLTERN-LPIYPLDIVRKMRDQRAMMVQTSSQYKFVC
||.|..| .|||||||..|...||....|.. . .|   .||.||||||.||||..|.......  |..   .  ..||...|.||. ||||  || |..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

EAIL
.|.|
rall

PTEN_1 812-903 3.6e-11 38.2 In-house 92-183 (196) alignment
Range on Protein: 812-903
Range on HMM: 92-183/196.0
VTHLQ--YVAWPDHGVPDDSSDFLEFVNYVRSLRVDS--EPVLVHCSAGIGRTGVLVtmetAMCLTERNLpIYPLDIVRKMRDQR-AMMVQTSSQYK
  ...   . ..|||.|. |. | . ..   .|. |.  . ||||| ||.||.|..|    |..| ...    . . .. .|..| .......|| .
ksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv....aayLmykgk.ltadeAlelvrekRppgapnspsqer

subfamily_PTPDC1_pd Subfamily PTPDC1 812-907 8e-10 33.4 In-house 83-170 (182) alignment
Range on Protein: 812-907
Range on HMM: 83-170/182.0
VTHLQyVAWPDHGVPDdSSDFLEFVNYVrSLRVDSEPVLVHCSAGIGRTGVLVTmeTAMCLTERnlpIYPLDIVRKMRDQRAMMVQTSSQYKFVCE
... . ..|.|.||.      |. |  | .  .. . | ||| || ||||||..  . .  ..|   . . . ....|..|.  .|| .| ..| |
iyvyn.fgwkDygvas.leriLdivkvv.afalqegkvavhChaGlGrtGvlia..cylvyakr...ltaekaiklvrskrpksiqtreqvelvke

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 812-911 3.7e-09 30.4 In-house 220-342 (349) alignment
Range on Protein: 812-911
Range on HMM: 220-342/349.0
VTHLQYVAWPDHGVPDDSSDFLEFVNyVRSL------------RVDSEPVLVHCSAGIGRTGVLVTMETAMCL----TER----NLPIYPLD----IVRK
.  ||.  |.| ..  .   .|. .. |..               .. ..||||||| ||||||||..  . .    ..     .|.    |    || .
llqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

MRDQRAMMVQTSSQYKFVCEAILR
.| ||  |||  .|. .. ||.|.
lrkqrismvqnlaqfiaiyealLk

0038934 (Phosphotyrosine protein) phosphatases II 815-905 7.5e-10 34.3 In-house 82-169 (194) alignment
Range on Protein: 815-905
Range on HMM: 82-169/194.0
LQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD--SEPVLVHCSAGIGRTGVLVtmetAMCLTERnLPIYPLDIVRKMRDQRAMMVQTSSQYKFV
     .||.|.. . .  |.|.. |     .  .. |.||| ||.||||.||    |  | .| | . . . .. .|. |  .... .... .
ylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlv....aaYLiyr.lgmsaeeAialfrekRpgaipnqdyleal

subfamily_CDKN3_pd Subfamily CDKN3 817-907 4e-06 20.5 In-house 104-190 (202) alignment
Range on Protein: 817-907
Range on HMM: 104-190/202.0
YVAWPDHGVPDDSSdFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTmETAMCLTERNLPIYPLDIVRKMRDQRAmmVQTSSQYKFVCE
.   .| .||| .|  |.... .|    .    ||||  |.||. ....    . | .   |   .| .|...  ||  .||  || .. |
hypiadglvpdias.clkileelrinlkayrktlvhcygglgrsslvia.clllylddtiepkdaidklrdlkgsra..iqtvkqynylse

PTPlike_phytase Inositol hexakisphosphate 818-866 3.8e-06 21.6 Pfam-A 98-144 (149) alignment
Range on Protein: 818-866
Range on HMM: 98-144/149.0
VAWPDHGVPDDsSDFLEFVNYVRSLrVDSEPVLVHCSAGIGRTGVLVTM
.. .|.  |.. .|. .||....||  ... ....|.|| ||| . ...
ipitdeqapee.edvDafvrliksl.prdtalvfnCqaGrgRTTtamvi

PTPlike_phytase Inositol hexakisphosphate 818-866 3.8e-06 21.6 In-house 98-144 (149) alignment
Range on Protein: 818-866
Range on HMM: 98-144/149.0
VAWPDHGVPDDsSDFLEFVNYVRSLrVDSEPVLVHCSAGIGRTGVLVTM
.. .|.  |.. .|. .||....||  ... ....|.|| ||| . ...
ipitdeqapee.edvDafvrliksl.prdtalvfnCqaGrgRTTtamvi

subfamily_CG42327_pd Subfamily CG42327 844-908 4.7e-10 33.6 In-house 245-310 (319) alignment
Range on Protein: 844-908
Range on HMM: 245-310/319.0
VDSEPVLVHCSAGIGRTGVLVTMETAMCLTERN-LPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEA
 .  |. |||| |.||||.... . |.   | .   .   ..|  .| .||  |.|  ||.|.   
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 847-911 1.4e-14 48.6 In-house 229-293 (297) alignment
Range on Protein: 847-911
Range on HMM: 229-293/297.0
EPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
 ..|||||||.||.||.|  .. .  . ..       |....|.|||..|||  |.... .|.|.
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 850-910 5.9e-08 27.0 In-house 2-62 (69) alignment
Range on Protein: 850-910
Range on HMM: 2-62/69.0
LVHCSAGIGRTGVLVTMET--AMCLTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAIL
.||||.| |||| ....    |   .|. . |.  . |. ||  | |||    .| |. .|. 
vvhcssgtgrtgtfiaimvemarikseklvdif..nnvqymrkcrpmmvmneieyifihdalv

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 851-910 8.2e-08 26.5 In-house 2-61 (69) alignment
Range on Protein: 851-910
Range on HMM: 2-61/69.0
VHCSAGIGRTGVLVTM--ETAMCLTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAIL
||||.| |||| ....  | |   .|. . |.  . |. ||  | |||    .| |. .|. 
vhcssGtGrtGtfiaimvemarikseklvdif..nnvqymrkcrpmmvmneneymfihdalv