Gene PTPN3 in Homo sapiens

Synonym: PTP-H1, PTPH1, RP11-18A3.3, PTPN3

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN3
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP080_AA protein Get Run
HsapP080_AA_639-914 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
FERM_N FERM N-terminal domain 44-122 1.1e-25 79.8 Pfam-A 1-80 (80) alignment 
Range on Protein: 44-122
Range on HMM: 1-80/80.0
IHFLDGVVQTFKVTKQDTGQVLLDMVHNHLGVTEKEYFGLQHDDDSVDSPRWLEASKAIRKQLKG-GFPCTLHFRVRFFI
...||| | ...| ...||.|||..| ..||.||.|||||. ..|. .  .||...| .|.|..  | |.||..||.|..
VrlLDgtvkevtvddsktgavlletVckrlglteteyFgLafkedkknesnwLdhdktlreqgveegkpttlllrvkfyv
FERM_M FERM central domain 124-233 7.4e-24 74.5 Pfam-A 1-126 (126) alignment 
Range on Protein: 124-233
Range on HMM: 1-126/126.0
DPNTLQQEQTRHLYFLQLKMDICEGRLTCPLNSAVVLASYAVQSHFGDYN-SSIHHPGYLSDSH-------FIP--------DQNEDFLTKVESLHEQHS
||| ...| ...|...|.| |. |.||.|. ..|..||....| ..||.. .. .  ..| ..        ..|         ..... ...   |....
dpnpkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllpvsprllkkekskqleqrileahknva

GLKQSEAESCYINIARTLDFYGVELH
||...||.  |...|..|  |||.|.
glslaeaklkylqaaqslpdyGvslF
FERM_C FERM C-terminal PH-like domain 239-323 4e-25 78.2 Pfam-A 3-86 (90) alignment 
Range on Protein: 239-323
Range on HMM: 3-86/90.0
HNLDLMIGIASAGVAVYRKYICT--SFYPWVNILKISFKRKKFFIHQRQkqaESREHIVAFNMLNYRSCKNLWKSCVEHHTFFQAKK
.. ||..|... |. .|.|  .   . .|| .| |.|||.|||.|..|.   |.... . |.. ..|..|.|.|.|.|.|..|. ..
kgtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrd...ekkkdvlkFyssqlrvnklllklcienhdlfrrrr
PDZ PDZ domain (Also known as DHR or GLGF) 522-605 8.7e-22 67.2 Pfam-A 2-80 (81) alignment 
Range on Protein: 522-605
Range on HMM: 2-80/81.0
IRITPDEDGKFGFNLKGGVDQK-MPLVVSRINPEsPADTCIPkLNEGDQIVLINGRDISEHTHDQVVMFIKASREshsrELALVI
... ... |..||.|||| |.. ....||...|  .|. . . |.|||.|. .||.|.....||..| .|| ...    |..|.|
vslekekrgglGfslkggsdkrdkgifvsevvpg.gaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkg....evtLti
0050432 (Phosphotyrosine protein) phosphatases II 640-914 8.5e-100 329.3 In-house 27-300 (308) alignment 
Range on Protein: 640-914
Range on HMM: 27-300/308.0
TLEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIpaANLVNKYIATQGPLPHTCAQF
...  . .|.| |..| .  .||.|...|| | ...|.||.| |||||||.|||| .|| |... ||||||||.. .   .| .|.||||||||.|.. |
svldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgys..sklprkfIatqgPlpntvedF

WQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDP--PDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVN
|. ||.|. ..|||||.|.|.|| ||.||||.    .....|.|.. . ||.    |. |.. .||...||..||||..| .|||||||.. ...|.|..
wrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfle

YVRSLRvDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE
.||. . ...|..||||||.||||........... |..  . ....|.|.| ||..|||| .||.|...|.|  ..
lvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0039614 (Phosphotyrosine protein) phosphatases II 640-913 1.5e-87 289.1 In-house 17-289 (297) alignment 
Range on Protein: 640-913
Range on HMM: 17-289/297.0
TLEGSMAQLKKGLESGTVLIQFEQLYRKKPGlaITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNED------YINASYVnmeiPAANL-VNKYIATQGPL
. .  . .|.| ......| .||.|.. ||   ...|.||.| |||||||.|||| .|| |.....      |||||||    .  .|  .|.|||||||
svldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv....dgydlltrkfIatqgPl

PHTCAQFWQVVWDQKLSLIVMLTTLTERGRtKCHQYWPDPPDvmNHGGFHIQCQSEDCTIAYVSREMLVTNtqTGEEHTVTHLQYVAWPDHGVPDDSSDF
|.|.. ||. ||.|. . |||||.|.|.|| ||.||||.  .  ..|.|.. . ...    |. |.. |||  .||..||||.||. |||||||......
petvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslell

LEFVNYVRSLRV---DSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
|||...||. .    ...|||||||||.||||..... ..... |..  . .|..|...| || ..||| |||.|...|.|  .
leflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_Ptp69D_pd Subfamily Ptp69D 640-914 2.3e-59 196.0 In-house 8-287 (307) alignment 
Range on Protein: 640-914
Range on HMM: 8-287/307.0
TLEGSMAQLKKGLESGTVLiQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVNmeipAANLVNKYIATQGPLPH
.|| .. . |.  . | .   .|.| ...  .  ....   |. ||||.|. ..| ||| |.      . ||||||...    . .  .|.|| |.|.  
dleealksrkrdtdfglak.eyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik....gykekkkfiaaqdPvea

TCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQ-----TGEEHTVTHLQYVAWPDHGVPDDS
|   ||.....|.. |||||. |||  | ||..|||.  | ...|   ... ||. .  |. ||. |....       ... |.  .| .|.|  ||. .
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

SDFLEFVNYVRSL-RVDSEPVLVHCSAGIGRTGVLVTMETAM--CLTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE
   |.... ||.| . .  |..|||||| ||.|..|...  .  . .| .. |.  ..|...| || ..||   ||.|.  |.|   .
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdif..etvkdLrsqRnllvqsleqYvflyralldyss
subfamily_PTPN3_pd Subfamily PTPN3 641-917 1.8e-146 481.4 In-house 1-279 (280) alignment 
Range on Protein: 641-917
Range on HMM: 1-279/280.0
LEGSMAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE-DYINASYVNMEIPAANLVNKYIATQGPLPHTCAQF
|. |...||.|||||.||.||||||||||||||. |..|.||.||||.|.||||.||| |. .| |||||.|||||||...|||.||||||||..|...|
lresllllkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdf

WQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYV
||.||.|| |||||||||.||||.|||||||.. | ...|.|...|..||.| .|| ||.......| ||.....|||.|||||||||||.||||||. |
WqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv

RSLR-VDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGL
|.|| ...|||.|||||||||||||...|||..|.|.. |.|||||||.|||||||.|||.|||||||||||.||||.|
rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyeeil
subfamily_PTPN14_pd Subfamily PTPN14 645-911 5.7e-76 250.4 In-house 13-294 (300) alignment 
Range on Protein: 645-911
Range on HMM: 13-294/300.0
MAQLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG----NEDYINASYVNMEIPAANlvNKYIATQGPLPHTCAQFW
. .|.| ||.| |  ..|.. .|.    .. ||||.| .|||.||||||. .|| |.     ...||||| ... . ...   .||..||||..|. .||
akilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggke..rsyivaqgPleltvqdfW

QVVWDQKLSLIVMLTTLTERGRTKCHQYWPDP---PDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVN
|.||.|...||||||  .| |..|...|.|.     . ...| |... .  . . ... . . .    ..|| || ||||. |||||||.| ..||....
qmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLe

YVRSLRVDS----------EPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
 |.|.|  .           |||||||||.||||||.. .  .   | |  |    .....| || ..||| .||||| .....
evqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_PTPN13_pd Subfamily PTPN13 647-913 6.9e-84 276.3 In-house 3-269 (273) alignment 
Range on Protein: 647-913
Range on HMM: 3-269/273.0
QLKKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIpaANLVNKYIATQGPLPHTCAQFWQVVWDQ
.|.| |....   .|..|   || .  . .|  .| |||||..||||| ||| |...  |||||......   .   .|||.|||||.|.. |||.||.|
alqkkldqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpv..gkdeyeyiacqGPlPetvkdfwqmvweq

KLSLIVMLTTLTERGRTKCHQYWPDPP--DVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV
| ..|.|.|.  |.|. |||.|||.     .. .. ....        ..| |.. |.....|| . |.||..|.|||||||  . ..|.|| .||.|. 
kaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt

DSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
|. |..|||||||||.|.|.|..... | ||. ..   .||||.|.||  .|||. || || .||| | 
dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 648-911 3.1e-71 235.0 In-house 14-278 (318) alignment 
Range on Protein: 648-911
Range on HMM: 14-278/318.0
LKKgleSGTVLI--QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNME-IPAANLVNKYIATQGPLPHTCAQFWQVVW
|..   ||..|.  ..|.| |..   . . .  | |  |||| ..|.||.|||.||  |.  .. |.| . |.  .  ..|||.|.|||.|.  ||..||
lre...sGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvW

DQKLSLIVMLTTLTERGRTKCHQYWPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-
.|. ..||||| ..|||..|.|.|||.  . ...|  ... ..|  .  || ||. ||.|.. |. .|   .| .|||.|||......|..|  |..   
eqnsavivmltqeeergkakvhryWPsk.gsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqq

-VDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
  . .|..||||||.||||| ..... .   . .  .  ...|...|.|| .|||| .||.|. ...| 
ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlle
0047943 (Phosphotyrosine protein) phosphatases II 649-910 1.3e-89 295.5 In-house 6-269 (273) alignment 
Range on Protein: 649-910
Range on HMM: 6-269/273.0
KKGLESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL-QGNEDYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQK
.| | ....| .||.|.. || | ...|.||.|.|||||||.|||| .|| | .|. ||||||||    .  || .|.||||||||.|.. ||. ||.|.
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyv....dgynlkrkfiatqgPlpntvedfwrmvweqn

LSLIVMLTTLTERGRTKCHQYWPDPPD--VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-
 ..|||||.|.|.|| ||.||||.  .  ....| |.. . ||.    |. |.. .||..|||..||||..|  |||||||.. ...|||...||. .  
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--DSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL
  ...||.||||||.||||........... |..  . .|..|...|.|| .|||| .||.|..||.|
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyeall
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 652-908 9.4e-22 71.8 In-house 23-280 (302) alignment 
Range on Protein: 652-908
Range on HMM: 23-280/302.0
LESGTVLIQFEQLYRKKPGLAItFAKLPQNLDKNRYKDVLPYDTTRVLLQ-GNEDYINASYVnmEIPAANlvNKYIATQGPLPHTC---AQFWQVVWDQK
|....|  .|...   |  |        .||.||. .||  .|...| |.  ...|.||| |  |.|  .  .. | .| |   .    ..||..|...|
ldtaevkkefkkidtmkvdlek.Ckafkknlkknqsedvpildsnlvkleaepdsyvnaskv..evPelt..rsiilaQlpkvdsedsveeFWrmvfqek

LSLIVMLTTLTERGRtKCHQYWP-DPPDVMNHGGFHIQCQSEDCTIAYV---SREMLVTNTQTGEEHTVTHLQYvaWPDHGVPDDSSDFLEFVNYV--RS
   .|.|    |  .   ....|    |  ..| . .  .  . . . .   . |.|  .       .|..|..  |... ||.  ..  . .  |  ..
ivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakvfakk

LRVDsEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEA
  .| |....    |.|| |...|. .|..  ...      .||...| ||. .|.. .|| ..  |
ikad.entvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyia
0036941 (Phosphotyrosine protein) phosphatases II 653-920 1e-90 299.3 In-house 11-284 (297) alignment 
Range on Protein: 653-920
Range on HMM: 11-284/297.0
ESGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE-DYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLI
 .  .| .||.|.. ..   .. |.||.||.||||||.|||| ||| |.... ||||||||    .  .| .|.||||||||.|.. ||. ||.|. . |
flalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyv....dgydlkrkfIatqgPlpntvedFWrmvweqnvtvI

VMLTTLTERGRTKCHQYWPDP-PDVMNHGGFHIQCQSEDC--TIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV---D
||||.|.|.|| ||.||||.  ......|.|.....|..      |. |.. ||.|..||..||||..|  |||||||.. ...|.|...||. .    .
vmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllps

SEPVLVHCSAGIGRTGVLVTMETAMCLTE---RNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLVQM
..|||||||||.||.|........... |   ..  . .|..|.|.|.||...||| .||.|..||.|  .  .|. .
ggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltke
0043336 (Phosphotyrosine protein) phosphatases II 654-910 4.9e-87 287.2 In-house 19-274 (278) alignment 
Range on Protein: 654-910
Range on HMM: 19-274/278.0
SGTVLIQFEQLYRKKPgLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKL
  ..| .||.|.. |.   ...|.||.| |||||||.|||| .|| |.      . ||||||||    .  |  .|.||||||||.|.. ||. ||... 
ktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv....dgynvprkfiatqgPlpetvedFwrmvwelgv

SLIVMLTTLTERGRTKCHQYWPdpPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-DSE
. |||||.|.|.||.||.||||   .....|.|.. ...|.    |. | . |||...||..||||..|..|||||||.. |..|.|...||. .  ...
ttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsng

PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL
|||||||||.||||........... |... . ....|...| ||...||| |||.|..||.|
pvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall
0045098 (Phosphotyrosine protein) phosphatases II 654-914 3.2e-85 281.1 In-house 6-273 (278) alignment 
Range on Protein: 654-914
Range on HMM: 6-273/278.0
SGTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLlqgneDYINASYVNMEiPaanlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVM
|. .|..||.|..  .   ||.| .. |||||||||.|||| .||      |||||||...  |     .|.||||||||.|.|.||. .|... . |||
sldlllefefllllgipseitpalylgnldknRykdilpydhsrVk.....dYINAsyidgy.p.....kkfIatqgPlpstvadfwrmlwelgitvivm

LTTLTERGRTKCHQYWPDpPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNT----QTGEEHTVTHLQYVAWPDHGVPDDS--SDFLEFVNYVRSLRV---
||.|.|.|| ||.||||.  .....|.|.. ..||. .  |. | .||||.    ...|...||||.|. |||||||...  . |||.....|. .    
ltelvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealklla

-----------DSEPVLVHCSAGIGRTGVLVTMETAMCLTerNLPIYPLDIVRKMRDQRAM-MVQTSSQYKFVCEAILRVYE
           ...|||||||||.||||.|| . . ..|   .  . .|..|...| || . .||. .||.|..|..|....
slllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
0051299 (Phosphotyrosine protein) phosphatases II 655-911 4.3e-92 303.9 In-house 23-284 (288) alignment 
Range on Protein: 655-911
Range on HMM: 23-284/288.0
GTVLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ-----GNEDYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLS
 ..| .||.|....| | ...|.||.||.||||.|.|||| .|| |.     .. |||||||.    .  || .|.||||||||.|.. ||. ||.|. .
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi....dgynlkrkfIatqgPlpntvedFWrmvweqnvr

LIVMLTTLTERGRTKCHQYWPDpPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNT----QTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD
.|||||.|.|.||.||.||||.  .....| ... . ||.    |. |.. |||.    ..||..||||..| .||||||||. ...|.|...||. . .
vIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalas

-SEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
 . ||.||||||.||||........... |..  . .|..|...| || .|||| .||.||.||.| 
gggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0040438 (Phosphotyrosine protein) phosphatases II 657-916 9.2e-90 296.4 In-house 20-279 (317) alignment 
Range on Protein: 657-916
Range on HMM: 20-279/317.0
VLIQFEQLYRKKPGlAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLI
.| .||.|.. |.   ...|.||.| |||||.|.|||| .|| |.      . ||||||||    .  || .|.||||||||.|.. ||. ||.|....|
lleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv....dgpnlkrkfIatqgPlpntvedFwrmvweqgvtvi

VMLTTLTERGRTKCHQYWPDpPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD-SEPVL
||||.|.|.|| ||.||||.  .....|.|.....||.    .. |.. |......|..||||..| .|||||||.. ...|.|...||. . | ..|||
vmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvl

VHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEG
||||||.||||........... |..  . . ..|...| ||...||| .||.|...|.|  .  .
VHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
0045450 (Phosphotyrosine protein) phosphatases II 657-913 1.6e-86 286.1 In-house 29-304 (307) alignment 
Range on Protein: 657-913
Range on HMM: 29-304/307.0
VLIQFEQLYRKKP--GLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ------GNEDYINASYVNMEI----PAANLVNKYIATQGPLPHTCAQFWQVVW
.| .||.|.. ..     ...|.||.| |||||||.|||| ||| |.      .. ||||||||.. .    .  .| .|.||||||||.|.. ||. .|
llkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrmlw

DQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNT-QTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR
.|. ..|||||.|.|.|| ||.|||||  .....| |.. . ||.    |. | . ||.. .|||..||||..| .|||||||.. ...|.|...||. .
eqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkal

V---DSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLP---IYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
    ...|||||||||.||||..... ..... |..     . .|..|...|.||  .||. .||.|..||.|  .
eelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_PTPN9_pd Subfamily PTPN9 657-911 2.8e-65 215.3 In-house 18-288 (297) alignment 
Range on Protein: 657-911
Range on HMM: 18-288/297.0
VLIQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN-----EDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLI
.  ..... ....   .. .||. || ||||.||| || ||| |.        |||||..|.      .  . .|||||||..|.  ||..||.|.   |
lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvd....GykqkkafiatqGplkktvsdfWrmvWeqevlvi

VMLTTLTERGRTKCHQYWP-DPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-------
|| | . |||| || |||| .  .....| ....  . ... .|. | . ..|..|.|. .||| |...|||.|||......|.... ||. .       
vmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkel

-------VDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
       ..  |..||||||||||| ..|.. ..   |.   .   . |...| ||| ..||  ||.|   |.| 
gdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 658-911 3.2e-62 205.4 In-house 25-281 (305) alignment 
Range on Protein: 658-911
Range on HMM: 25-281/305.0
LIQFEQLYRKKPGLAITfaKLPQNLDKNRYKDVLPYDTTRVLLQG---NE--DYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIV
  |...||...  . ..  |  .|  |||.|.. ..|. |. |.    ..  ||||||||.    . .  .|||..||||..| |.||..... | | ||
eaqykslyeeeesidvg..kkeankaknrlkeitlldddriiltekeslddsdyinasyvd....gykrkkkyivaqgPlkntvadfWrliveekvstiv

MLTTLTERGRTKCHQYWPDPPDV-MNHGGFHIQCQSEDCTIAYVSREMLVTN-TQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDS--EP
||| | | |. ||.||||.     ...| |... .||  .  |. |.. ...  .  |..||...|   |||||||. .. .|.... |.  .  .   |
mltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvp

VLVHCSAGIGRTGVLVTMETAM--CLTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAILR
.|||||||.||||| .... |.  . .|  . ..  ......| .|  ||||  || |. .|.  
llVhCsagvgRtGvfiavdialerlkkEevvdvf..evlkqlRskrmkmvqtldqYvflhdalde
0046845 (Phosphotyrosine protein) phosphatases II 659-913 1.1e-90 299.2 In-house 4-274 (284) alignment 
Range on Protein: 659-913
Range on HMM: 4-274/284.0
IQFEQLYRKKPGL--AITFAKLPQNLDKNRYKDVLPYDTTRVLLQ------GNEDYINASYVNME-IPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLS
 .||.|.. .. |   ...|.||.||.||||||.|||| .|| |.      .. ||||||||..  ..  .  .|.||||||||.|.. ||..||.|. .
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

LIVMLTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQ-TGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD---
.|||||.|.|.||.||.||||.  .|...|.|.. . ||.    |. |.. .||.. |||..||||..| .|||||||....|.|||...||.|. .   
vIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpg

SEPVLVHCSAGIGRTGVLVTMETAMCLTERNL---PIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
..|..||||||.||||........... |..     . .|..|...|.|| .|||| .||.||.||.|  .
ggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleyl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 659-915 1.6e-75 248.8 In-house 19-278 (281) alignment 
Range on Protein: 659-915
Range on HMM: 19-278/281.0
IQFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNME-IPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTL
 ..|.|.    . . | .| ..|  ||||...  || ||| .. ||.  |. |.| . .|. .  ..|||||||.|.....|||.||.|| |.|||.|  
eeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtre

TERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVtNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE--PVLVHCSA
 | |. |||.||||.   .. | .... ..|  .  |..|.. . ....||. .|..|.|.||||||||......||| . |..|.  ..  |...||||
ieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCsa

GIGRTGVLVTMETAMCLTERN-LPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE
|.||||. .......   |..  .. . ..|...| .| .||||  ||.||  |.|.. ..
GvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 659-913 3.7e-41 136.1 In-house 20-277 (307) alignment 
Range on Protein: 659-913
Range on HMM: 20-277/307.0
IQFEQLYRKKPGlAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG---NEDYINASYVNMEIPAanlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLT
 .|..| .|.|  ..|   .  | |||||.||   | .|....      ||| | |. . |      .|.|..||||  |  .|| .. ..|.  ..|| 
defrvlakktpe.gvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikp....kkficaqgplentqysfwamaiqekvesvimlc

TLTERGRTKCHQYWPDPP---DVMNHGGFHIQCQSED-CTIAYVSREMLVTNTQ---TGEEHTVTHLQYVAWPDHGVPDDSsdfLEFVNYVRSLRVDSEP
 . | .. ||.||||       |. . .  |  .     ..|     . ||. .   ...  |..|||.  |||.|||.     |  .| . . | | .|
kvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqin...ltainlleavrydtnp

VLVHCSAGIGRTGVLVTMETAMCLTERNLPI-YPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
|.||||||.||.| .|..   .    .        ..|...|.||   .||  || ..   .|  .
vvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 659-911 7.9e-38 124.9 In-house 19-291 (301) alignment 
Range on Protein: 659-911
Range on HMM: 19-291/301.0
IQFEQLYRKKPGLAiTFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE-------DYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLI
 |...|.....  . |     .|   ||.|.. .||  |..|. ..       .||||||..    . .  .|.||.|||. .| ..||...|..| . |
eqykelkegedksc.tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyid....gysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMLTTLTERGRTKCHQYWPDPPDV-MNHGGFHIQCQSEDCTIAYVSREMLVTNTQT---------------GEEHTVTHLQYVAWPDHGVPDDSSDFLEF
||.| | |. ..||.||||.      . | |... ..|     .| |.. |. ...                . ..|. || . ||..||  .    |. 
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqv

VNYV--RSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
.. |  |  ...  ||.||||....|.|| .... ..    ..  .   .... .| ..  .|.|  || .. ..| .
iddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm
DSPc_SM00195 660-913 8.4e-86 282.9 In-house 5-262 (263) alignment 
Range on Protein: 660-913
Range on HMM: 5-262/263.0
QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN-----EDYINASYVNMEipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVML
.||.| ....   .| |. ..| .|||||..|||| ||| |. .     .|||||.|....    |  .||||||||||.|...||..||..| ..||||
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TTLTERGRTKCHQYWPDPP-DVMNHGGFHIQCQSEDCTI-AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-DSEPVLV
|   |.|..||..|||.   . ...| ......... .   .. |.. .|.... |...||..|| .||||||||. ...||....|.. .   |.|..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
|||||.||||..||.....   |..  .   .||...|.||..||||. ||.|..||||...
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 660-913 8.4e-86 282.9 In-house 5-262 (263) alignment 
Range on Protein: 660-913
Range on HMM: 5-262/263.0
QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN-----EDYINASYVNMEipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVML
.||.| ....   .| |. ..| .|||||..|||| ||| |. .     .|||||.|....    |  .||||||||||.|...||..||..| ..||||
efekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TTLTERGRTKCHQYWPDPP-DVMNHGGFHIQCQSEDCTI-AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-DSEPVLV
|   |.|..||..|||.   . ...| ......... .   .. |.. .|.... |...||..|| .||||||||. ...||....|.. .   |.|..|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
|||||.||||..||.....   |..  .   .||...|.||..||||. ||.|..||||...
hCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRB_pd Subfamily PTPRB 660-915 5.1e-79 260.4 In-house 30-287 (293) alignment 
Range on Protein: 660-915
Range on HMM: 30-287/293.0
QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL-----QGNEDYINASYvnmeIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVML
..|.|   .   |...|.|..| .||||...||||..|| |     . ..|||||.|    ||  |  ...||||||||.|  .||..||..| | ||||
eyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinany....ipgynsprefiatqGPlpetvddfWrmvwekkssiivml

TTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNtqTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR---VDSEPVLV
| | |.|..||..|||.  . ...|  ... ..|. .  .| ||.....  . ||..|.......|||||||.... .|.||. ||.      ...|..|
tqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPivv

HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE
|||||.||||....... .   |..  .  . || ..| .|...||| .|| |. ...|.. ..
hCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_PTPN6_pd Subfamily PTPN6 660-912 1.5e-72 239.2 In-house 31-296 (306) alignment 
Range on Protein: 660-912
Range on HMM: 31-296/306.0
QFEQLYRK--KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLL----QGNEDYINASYVNMEIPAANlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVM
.||.| ..  |  |  . .. |.|  ||||| .||.| ||| |      ..|||||.|.. |..  .  ..|||||| |..| ..||..||...  .|||
efeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd..ksyiatqgclettvsdFWrmvwqensrvivm

LTTLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVT-NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE-----
.|. .|||. || .||||  .  ..|  .... ||. . .|. ||..|. ... .||..| .... .||||||| | . .|.|.. |.. . ..|     
ttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeag

PVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDI---VRKMRDQRAMMVQTSSQYKFVCEAILRV
|..||||||||||| .. ... . | |..   ...||   |...|.||  .||| .||||| .||   
pivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
subfamily_PTPRG_pd Subfamily PTPRG 660-912 1.1e-59 197.1 In-house 24-286 (563) alignment 
Range on Protein: 660-912
Range on HMM: 24-286/563.0
QFE--QLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ------GNEDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLI
.||  |   ..  | ..... |.|  |||| ....|| .|| |.      .. |||||.|..      .  ...|||||||..|.  ||...|.|. ..|
efealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyid....GyqkskafiatqgplkdtfddFWrmiWeqnvaii

VMLTTLTERGRTKCHQYWPDpPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQ------TGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD
||.| |.|||| ||..|||   .... | .... ..|. .. | .|.. . |..      . .|..|.. .|  |||||||. |   | ||.     . .
vmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaanka

-SEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV
   |..||||||.||||... ..| .   ...  .  .......| || ..|||  || |. .|.| .
eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 660-914 5.4e-57 187.9 In-house 25-284 (290) alignment 
Range on Protein: 660-914
Range on HMM: 25-284/290.0
QFEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ---GNED----YINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIV
||..|   .   ..| .  ..|  .||......||  |. |.   |..|    ||||.|..      .  ..|||||||...| ..||...|..| . ||
qfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik....gykekkqyiatqgpvsntlvdFWkliwqekvtiiv

MLTTLTERGRTKCHQYWPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQT-GEEHTVTHLQYVAWPDHG-VPDDSSDFLEFVNYVRS-LRVDSEPV
|||. .| |..||.|||||  |. . | |.|. ..|  .  |. |.. |.|... |....||..|  .|...| |.. ..  | . . ..   .   ...
mltniieegkvkCqqYWpds.dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgntsi

LVHCSAGIGRTGVLVTMETAM--CLTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE
.||||...||..|.....|..  | ||    ..  ......| |.  .|||  ||..... .|.  .
vvHCSdtvgrsavfcaaattinkcktegvidvf..qvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 660-907 3e-35 116.3 In-house 32-284 (310) alignment 
Range on Protein: 660-907
Range on HMM: 32-284/310.0
QFEQLYRKKpGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG----NEDYINASYVNMEipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLT
|. .|  |.   ..|.    ... |||| ||.  ||.|| |.      |||| | ||. .     | . .| .|||| ||  .||.......   |..| 
qyrkldakq.dssltyeaykkymhknrysdvvcldtsrvklkidksryedyihanyvktn....ylrstficsqgplqhtiidfwrmifqeraesilllc

TLTERGRTKCHQYWPDPPDVMNHGGFHIQCQSED------CT--IAYVSREMLVTNTQT-GEEHTVTHLQYVAWPDHGVPDDSSDFlefVNYVRSLRVDS
  .| || ||  |||       .|   .   ||       |   ...|  .. | .  .  .|  |. ...  ||| ||||.       |      .|  
kvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekcht...vpqrllaqvrh

EPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE
 |..||||||..|..|.|... ..  ..| | .   ... ... .||. .||  || ..  
gpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr
subfamily_PTPN12_pd Subfamily PTPN12 661-918 9.1e-71 233.1 In-house 20-282 (290) alignment 
Range on Protein: 661-918
Range on HMM: 20-282/290.0
FEQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN-----EDYINASYVNMeipaANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLT
 .. |...     . .. ..|  ||||||.||||..|| |. .     .|||||....     ..   .|||.|||||.|  .||...|.......||. 
lsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikg....vegkleyiaaqgPLpktlddfWrmiweknveivvmaC

TLTERGRTKCHQYWPDPPD-VMNHGGFHIQCQSEDCTI-AYVSREMLVTNTqtGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV-DSEPVLVH
 . | |..||..|||.  .  ...| |......|. .   .. | . |..   .|...|. ..| ||||||||   .. ||... ||.|.  ...|..||
revelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvh

CSAGIGRTGVLVTMETAMCL-TERNL--PIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEGLV
||||.||||...... .  |  ....   .   |.|...| ||| .|||  ||..| .|.. . .. | 
CsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 661-913 3.5e-53 175.6 In-house 26-279 (315) alignment 
Range on Protein: 661-913
Range on HMM: 26-279/315.0
FEQLYRKKPGL---AITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNME-IPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTT
|.| |   ||     .  ||  .| .|||| ....|| .|| |   |   .. ||| . |.  |  ..|||.|||.. .   ||..|...... ||||| 
fkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltn

LTERGRTKCHQYWPDPpdVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQtgEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDS-EPVLVHCSA
| |. . |. .||||    . .| . .  .||.    |  | . |.  .  . ..|  |.| .||| |||  .  .....  |.  . .|  ...|||||
lvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvvfgd..nirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsa

GIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
|.|||| ..|... .   | .  |   ......|..|  |||.  ||.|. .|.|  .
GvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 661-911 9.7e-42 137.9 In-house 26-277 (439) alignment 
Range on Protein: 661-911
Range on HMM: 26-277/439.0
FEQLYRKKPGLAITFAKLPQNLD--KNRYKDVLPYDTTRVLLQGNE-----DYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVM
||..   .|  |   . . |. |  ||||||| ..| ||| ||         |||| |..         . |||||||  .|. .||..|...| . |||
fekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyik....Gyyddklyiatqgpkkettddfwrlviekktvtivm

LTTLTERGRtkchqYWPDPPDVMnHGGFHIQCQSEDCTIAYVSREMLVTNT--QTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV--DSEPV
|| | |  .     |||   .|. .|   .... .     || | . | |   .|  |.|| ...|.||||. || ..|  |.|.  . |     .  ||
ltnlvesyk.....ywpsdaevc.ygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpv

LVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
.||||||.|||| ..... |.     .  .    ||. .|.||  |||.  || |. .|.| 
vvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 661-916 2.6e-25 83.7 In-house 28-283 (303) alignment 
Range on Protein: 661-916
Range on HMM: 28-283/303.0
FEQLYRKKPGlAITFAKLPQNLDKNRYKDVLPYDTTRVLLQgNEDYINASYVNMEIpaanlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTER
||..    |   ..  .. .|.||||. ||.  | ..| |  .  || |||....       .| | || ||.||.|.|||.. .||.  ...| | .| 
fekvvsylpp.svsknqfvknmdknrfvdvicldhskvkls.dssyihasylelds.....skkailtqlplshtaadfwqmiieqkvkcvlllltdsey

GRTKCHQYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHL-QYVAWPDHGVPDD-SSDFLEFVNYVRSL-R--VDSEPVLVHCSA
 .   .  .|   | ..     |.              . |     |. ..  |. .| |||   .| | |. |.  .  ..|. |   ||.| .    .
dklggdsvfprnqdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymsls

GIGRTGVLVTMETA-MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL-RVYEEG
| ||.| .  .||| . | . .  .  .  . ..|. |   ||  ||. .|   .   | ..|
gcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldng
subfamily_PTPRD_pd Subfamily PTPRD 662-912 1.5e-80 266.4 In-house 30-280 (564) alignment 
Range on Protein: 662-912
Range on HMM: 30-280/564.0
EQLYRKkPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ-----GNEDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTT
... .. .   .. |. |.|  ||||.....||..|| |.      . ||||||...    . .  ..||||||||..|.. ||. ||.|. | ||||| 
kkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid....gyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltk

LTERGRTKCHQYWPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSA
| |.|..|||.|||.  .  ..|..... ..|     |. |.. ...... | ..|.. ....|||||||.   ..|.... ||.|.  |..|..|||||
leEkgkvkchkYWPek.gtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCSa

GIGRTGVLVTMETAMC--LTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAILRV
|.||||. ....  .    .|... ||   .|...| || .|||| .|| |. ||||  
GVGRTGtfividamlerikeektvDiy..qyvkalrkqRnamVqteeQYiFiheailea
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 662-912 7.5e-59 194.6 In-house 41-292 (319) alignment 
Range on Protein: 662-912
Range on HMM: 41-292/319.0
EQLYRK-KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ---GNE--DYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLT
 .. ..  ..   ||| |.|| ||||. ..|..| ..| |.   | |  ||||||.|.         .||||.||||. | | ||...|... | ||.||
rracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvt....GyqrkdkyiaaqGPldntladfWrmiweyncstivllt

tltergRTKCHQYWPDPPDvMNHGGFHIQCQSEDCTIAYVSREMLVTN-TQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV---DSEPVLV
      . || ||||   . .... |... .| . |  || |.. ... ..  .   .|   .  |||.|||| .||.. .|. || |.    . ....|
......kdkcsqywplkiv.ikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivv

HCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR--V
|||||.||||| ..... .   ...  .   ..|| .|.||  .||   ||||.  |.|   .
hcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 662-841 9.5e-38 124.7 In-house 14-195 (297) alignment 
Range on Protein: 662-841
Range on HMM: 14-195/297.0
EQLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG---NEDYINASYVNMeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLT
. |.... | . . || .  | ||||.|.| .|.||| |..   ..||||| || .  |  .   ||| .||||  |  .||..|..| .  |||.. | 
dllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvf..pdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklq

ERGRTKCHQYWPDPPDVMNH-GGF---HIQCQSEDCTIAYVsREMLVTNTqtGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS
| || ||  |||.  .   . | .   ..   |..    ..  |. .      |.  |.| |...||||||| |  |   |   | |
edGrdkcapywpsvvqerlkagdvvveflsstsdefdrvil.telqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcs
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 663-916 2.2e-50 166.6 In-house 30-291 (325) alignment 
Range on Protein: 663-916
Range on HMM: 30-291/325.0
QLYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ-----GNEDYINASYVNMEIPAanlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTL
.|   . | | . | .|.| .|||.|.|...| .|| |.     .. |||||||.. ..      . ..|.| ||..|   .|..| | . |..|.|  |
gllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk....dvflaaqaPltatindlWrlvldWrcsvvvvlnel

tERGRTKCHQYWPDP-PDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS----LRV---DSEPV
 . |  .| .|||.   .  . ||.... .. .    || | . | ... ||  .|  .|. .|.| ||.   . .. ... |      ..     | |.
.dlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpi

LVHCSAGIGRTGVLVTMETAM--CLTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEG
|||||||.|||||.... .|.   ..| .. |.  . |.|.| .|  ||.|  || .. ||.  .|  |
lvhcsaGvGrtGvfislysalakvieesrvdif..gfvkklrkdrpsmvetvdqyiliyealveaymsg
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 664-910 1.6e-33 110.6 In-house 20-266 (281) alignment 
Range on Protein: 664-910
Range on HMM: 20-266/281.0
LYRKKPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG------NEDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTL
|    |    |  . | |  |||| ..   | .|| |.         ||| | |.     .  |   || ||||   | |.||...|... . ||||  .
lpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyir....spflkrgyiltqgpkketradfwrmiwqenttaivmlcqf

TERGRTKCHQYWPDPPDVMNHgGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEfvnYVRSLRVDSEPVLVHCSAGI
.|  | || .|.|    .  .   ..  . || |.        .  .  || . .||  .  |||  ||. |  .|.    .| .|  | | ..|||||.
letnrekcaeyfprnahcclq.fdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlk...ilrkirarstppvihcsagv

GRTGVLVTMETAMCLTERNLPIYPL-DIVRKMR-DQRAMMVQTSSQYKFVCEAIL
||.| |...| |.      . .  . .|| ..|   ||  |||  || .. . .|
grsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
subfamily_eak_pd Subfamily eak 664-840 1.9e-16 54.4 In-house 35-208 (332) alignment 
Range on Protein: 664-840
Range on HMM: 35-208/332.0
LYRKKPGLAITFAKLPQNLDKNRYKdVLPYDTTRVLLQG----NEDYINASYvnMEIPaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTE
| .... |.|. ..  .....| .| ..|||   | |      .. |||||   .| .  .. .||| |  .       |||.| .||   ||.|    |
lddyqrllsisetarleavnrnvvk.ivpydrylvrltssqlnrlGyinasl..aefs..evGrkyiltGiasedkvfafwqmvleqkspaivqlledve

RGRTKCHQYWPDPP-DVMNHGGFHIQCQSEDCTIAYVSREMLVTntQTGEEHTVTHLQYVAWPDHGVPDdSSDFLEFVNYVR
 .  |  .|.||   .....| .......      .  | . ..  .  | | | | ..  | .  .|    ||| . . ..
lkleksdkyfpdktreelkfGildverkefvkrniletrllels..kGnethrvlhykvfGwtettlpk.yedflalrkvmk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 668-915 3.4e-62 205.3 In-house 36-285 (319) alignment 
Range on Protein: 668-915
Range on HMM: 36-285/319.0
KPGlAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE-----DYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGR
..   .. |. ..| .||||...|.|| ||| |.  .     ||||||...    . .  .|.||||.|| .|   ||..||... | .|||| |.|...
vnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfid....gyqerekfiatqaPlentiedfWrmvWeeessivvmltklveklk

TKCHQYWPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVtNTQTGEE--HTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR--VDSEPVLVHCSAGIG
 |...|||.  .... | . .. ..|. .  |. |.. . |....|    .|.| || .||||.||...   |.... .|  |   .| |. ||||||.|
vklkkywpee.nfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvG

RTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE
|||  .... ..   ...  .    .|...| || .|||. .||||. ||.| . | 
RtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 668-912 3.7e-58 192.3 In-house 12-256 (284) alignment 
Range on Protein: 668-912
Range on HMM: 12-256/284.0
KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ---GNE--DYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTtltergR
 .|   ||| |.|| ||||. ..|..| ..| |.   |.|  ||||||...         .|||||||||. | | ||...|... | ||.||      .
vngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfit....GyqrkdkyiatqGPldntladfWrmiweyncstivllt......k

TKCHQYWPDPPDvMNHGGFHIQCQSEDCTIAYVSREMLVTN-TQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV---DSEPVLVHCSAGIG
 || ||||   . .... |... .| . .  || |.. ... ..  .  ...   .  |||.|||| .||.. .|. || |.    . ....||||||.|
dkcsqywplkiv.ikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvg

RTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR--V
|||| ..... .   ...  .   ..||..|.||  .||   ||||.  |.|   .
rtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 668-911 1.5e-51 170.0 In-house 20-264 (283) alignment 
Range on Protein: 668-911
Range on HMM: 20-264/283.0
KPGLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-NEDYINASYVNMEIPAANlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCH
 | |  . |   .|  |||.....|.|  || |.  ..|||||... ..    .  .|||..|.|| .|   ||..|.|.| . ||||| | |  | || 
vpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsksykq.dkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

QYWPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVTNT-QTGEEHTVTHLQYVAWPDHGvPDDSSDFLEFVNYVRSLRVDS--EPVLVHCSAGIGRTGVL
||||     ...| | .  . |    ... .|.|. .   . ..  ..| |.. | . | ..   . |  .| |.||. .|   |..||||.|||||.|.
qyWPkr.GsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleyg.eqaiinslvkfnkvislqteskkgPivvhCstgiGrtavf

VTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
... ...     .  .    .|. || || |.|||  |||.| |..| 
iaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 669-911 8.7e-59 194.0 In-house 28-274 (515) alignment 
Range on Protein: 669-911
Range on HMM: 28-274/515.0
PGLAI---TFAKLPQNLDKNRYKDVLPYDTTRVLL-----QGNEDYINASYvnmeIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTER
||  |   | |.   |  |||||..||||..|| |     . ..||.||||    ||. .  . |||.|||.. .   ||..|.... . |.|.| | | 
pgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasy....ipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkeg

GRTKCHQYWPD-PPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTgeEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD-SEPVLVHCSAGIG
 . || .|||| | | .. | ....  | ..    . |.. |.  .    .|||  ..  |||.||| ..| .| ..  |.. .   . |...|||||.|
dkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvG

RTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
||||.....  .   .    .  ...|...|..|  .|||  || |. .|.| 
rtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavle
0049772 (Phosphotyrosine protein) phosphatases II 669-910 7.7e-42 139.5 In-house 34-277 (314) alignment 
Range on Protein: 669-910
Range on HMM: 34-277/314.0
PGLAITFAKLPQNLDKNRYKDVLPYDtTRVLLQG----NEDYINASYVNMEipaanlvNKYIATQGPLPHTCAQF----------WQVV--WDQKLSLIV
| | |..|.|. | |||||.|.||.| .|| |.|    . ||||||||.         .|.|||||||..|.  |          |..|  .|...  ||
peltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdiv

M---------------------LTTLTERGrtkchqywpdppdvmnhggfhiqCQSEDCTIAYVSremL-------VtntqtgeEHTVTHLQYVAWPDHG
|                     |..|...|                       ..   .....             .       |... .. .. .||..
msrdevladelsrLdaAlgKtpllildgng.......................neptaadlellk...eelydpelf.......erlgikylripvpDgs

VPdDSSDFLEFVNYVRSLrVDSEPVLVHCSAGIGRTGV-LVtmeTAMCLTERNLpiYPLDIVRKMRDQRA-----MMVQTSSQYKFVCEAIL
.| ...||.||.......  . .||||||.||.||||. .|   .|...  ...   . .... .| .|       ....  || |. ||.|
ap.lledfdeflefieea.dkggpvlvHCkaGkgRtgtfvv...aaylmkllgv..sleealedvrlkRpinpnpgfieqleqyefileall
subfamily_PTPN23_pd Subfamily PTPN23 670-913 3e-66 218.2 In-house 34-280 (288) alignment 
Range on Protein: 670-913
Range on HMM: 34-280/288.0
GLAITFAKLpqNLDKNRYKDVLPYDTTRVLLQGN-EDYINASYVNMEIPAAnlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQY
. .|. |||  . .|||..|.|||| .|| |.|. .||||||.|.   | .    ..||||.||. | . ||..|..|| |.||||.. .|.|..|...|
krsiaiakl..yseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgc...PdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrY

WPDPPD-VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS-----LRVDSEPVLVHCSAGIGRTGV
||   .  ...| ... ..|.  |  .| |.. ..  .. . ..|.|||. .||..|||.  ...|.|.. |.|      |    |..||||||.|||||
wPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgv

LVTMETAMCLTE-RNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
.  . .|.  .| .|  .  ...|...| ||  |||...|.||. ||.|.  
falvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_PTPN1_pd Subfamily PTPN1 670-911 4.1e-65 214.4 In-house 21-269 (290) alignment 
Range on Protein: 670-911
Range on HMM: 21-269/290.0
GLAITFAKLPQNLDKNRYKDVLPYDTTRVLLQ-GNEDYINASYVNMEipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQY
 . .. ||||.| ..|||.|| ||| .|. |. .. |||||| |..|    ..  .|| ||||||.|.. |||.||.||   .|||  . |....||.||
dfptreaklpenrnlnryrdvspydhsrikleradndyinaslvele....eakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPDPPD----VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVR---SLRVDSEPVLVHCSAGIGRTG
||   .    ....  ....  ||. .  |. | . ..| .| | ....|  |..||| |||.  . ||.|.  ||   ||  |  |...||||||||.|
wPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsG

VLVTMETAMCLTERNLPIYPLDIVR---KMRDQRAMMVQTSSQYKFVCEAILR
 .. ..| . | |..  .  .|| .   ..| .|  ..||  | .|   ||| 
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 671-914 8.6e-57 187.3 In-house 37-279 (287) alignment 
Range on Protein: 671-914
Range on HMM: 37-279/287.0
LAITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN-EDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYW
  .| .  .|| ||||....|..|  ||||.|. .|||||....    . .  ...|....|. .|  .||....|.. . ||||. ..|  . .|.|||
devthniasqnkdknRltqilvpdnyrvllkgehpdyinavfid....gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyW

PDPPDvMNHGGFHIQCQSEDCTIAYVSREMLVTNTQ-TGEEHTVTHLQYVAWPDHG-VPDDSSDFLEFVNYVRSLRV-DSEPVLVHCSAGIGRTGVLVTM
|.    .  | ..|.  .|. .  |. |.. |.|.. .|....|.  |. .|...| |..  . .| . . ... |     ...||||...||..... .
peeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaa

ETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE
.|..  ....  |  .......| |.  .||| .||||.....|   .
attinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 672-916 1.6e-75 248.9 In-house 38-283 (288) alignment 
Range on Protein: 672-916
Range on HMM: 38-283/288.0
AITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVNMEipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCH
. | ..|..| .||||...|||| .|| |..     ..|||||||.. |    .  .|||||||||..|  .||..|...| | ||||| | |.|.|||.
svtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge....kkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkCe

QYWPDPPDVMNHGGFHIQCQSEDCTIAYVSREMLVTntQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSAGIGRTGVLVT
.||||  .  |.| . .. ...  .  .| |..|.   ....| ..|..|| ||||||||... ..||... |      |..|..||||||.||||. ..
eYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFia

METAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE-EG
.....   |..  |  ...| |.| |||..||| .|| |. |..| . | .|
ldalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedg
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 672-913 2.2e-67 222.4 In-house 47-290 (298) alignment 
Range on Protein: 672-913
Range on HMM: 47-290/298.0
AITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCH
  . |. |.| .|||| |....| .||.|.      . ||||||...    |..  | .||||.||..| ..||..|.... . |||||.|.| ..||.|
ekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh....aykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyh

QYWPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE--PVLVHCSAGIGRTGVLV
.||||     ..| .... .|..    ...|.. |..... .|..| .|... |||.|||  ..  |.... ||  . ..   ||.|.||||.||.|  .
kywPde.gketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfi

TMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVY
 ... .   ...  .  ...|. .| .|. .||| .||.|. ||.|.. 
aidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 672-914 2e-53 176.0 In-house 27-278 (287) alignment 
Range on Protein: 672-914
Range on HMM: 27-278/287.0
AITF--AKLPQNLDKNRYKDVLPYDTTRVLLQGN----EDYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKC
..||  |.   .  |||| ||||.| |||||  .     ||||| ||    .. .  ...||.|||.. |  .||..|.... . ....|   | .| ||
tatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyv....asytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkc

HQYWPDPPDVMNHGGFHIQCQSEDCT-IAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYV----RSLRVD--SEPVLVHCSAGIG
..|||..   |  ||. .   . |     |  | . . . .| | . |  |....|||....  .  .. ||  |       |      |..||...|||
ykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiG

RTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE
|.|.|... . .   |    . .  .| ..| .|| .||.  |.....||.   |.
rsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 672-753 2.9e-09 30.9 In-house 28-115 (347) alignment 
Range on Protein: 672-753
Range on HMM: 28-115/347.0
AITFAKLPQNLDKNRYKDVLPYDTTRVLLQGN----------EDYINASYVNMEipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVM
 .|...  ..|.||| |||   |.|||.|  .          | |||||.....    |  ..|| || |||.|  .||..|   |.. .| 
kftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfd....naskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 672-764 4.1e-07 23.8 In-house 25-117 (332) alignment 
Range on Protein: 672-764
Range on HMM: 25-117/332.0
AITFAKLPQNLDKNRYKDVLPYDTTRVLL---QGNEDYINASYVNMEipaaNLVNKYIATQGPL-PHTCAQFWQVVWDQKLSLIVMLTTLTERGRTK
  |. |. .|.| ||   .  .| .|| |   .|..|. |||.|.      .  . || .| |.  ||   ||..| ..| |.|...  . |. . |
pntydkflnnmdmnriphlycfdhsrvelapqdgkddfynaswvdgy....skksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 673-911 5.1e-60 197.9 In-house 36-275 (315) alignment 
Range on Protein: 673-911
Range on HMM: 36-275/315.0
ITFAKLPQNLDKNRYKDVLPYDTTRVLL-----QGNEDYINASYvnmeIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQ
 . |. ..|  |||||..||.|..|| |     . ..|||||||    |.. .  . |||.||||. .   ||..|...| . |||.| . |  . || |
qrvaretinfkknryknilPldsarvkleviddsPdsdyinasy....iksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPD-PPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNtqTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSAGIGRTGVLVT
||||   | .. | ....  | . .   | |.. . .  . | .|||  |.  |||.||. ..| .|...  |.. .  .  ..|||||||.|||||...
ywPdrkadsvefGsikvellsleadtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvis

METAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
..  .   .|.  .  ...|...|..|  .|||  .| |. .|.| 
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle
subfamily_PTPRN_pd Subfamily PTPRN 673-910 4.7e-54 178.1 In-house 48-289 (297) alignment 
Range on Protein: 673-910
Range on HMM: 48-289/297.0
ITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVNMEIPAAnlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQ
 . || ..|..|||.|.||||| .|| |.      ..|||||| .  . | |     ||||||||..| |.|||.||.|   .||.||.|.| | ..|..
kevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdpra...payiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckr

YWPDPPDVMnHGGFHIQCQSEDCTI-AYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYV-RSLRVDSEPVLVHCSAGIGRTGVLVT
||||    . .. . ..  ||      |. | . . | || |  ||| . ...||..|||  .  .|||   | .| |  | |..||||.| ||||| . 
ywpdeGsev.yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyil

MEtaMCLTERNLPIYPLDI---VRKMRDQRAMMVQTSSQYKFVCEAIL
..  . |.  .  .  .||   . ..||||. .|.| .|..|.  |. 
id..lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 673-912 5.8e-43 141.9 In-house 27-269 (285) alignment 
Range on Protein: 673-912
Range on HMM: 27-269/285.0
ITFAKLPQNLDKNRYKDVLPYDTTRVLLQG-NEDYINASYVNMeiPAANlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD
 |..    | | ||| ||   . |||.|.  . ||| ||.. |  |  .  . ||.|||||| | ..||......|.. ..|| || | |  ||  |.|.
ctytayeanpdlnryadvrcieetrvvlknhdrdyihaswmrm..pgkd.qstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

P-PDVMNHGGFHIQ---CQSEdCTIAYVSREMLVTNTQ--TGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVT
   .|.. | . |    |. | .    .   . |.||.  . |   . |.|   |||.  |.|.  ..|. ..|. .    .|. ||||||.|||  .| 
klgevvkfgkyeitlteckee.aiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkekpicvhcsagvgrtatfvg

METAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV
.. |      |  |  |||||.||  |   ||.  |. |.   ..  
idyatirimenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 673-911 1.7e-42 140.2 In-house 37-234 (392) alignment 
Range on Protein: 673-911
Range on HMM: 37-234/392.0
ITFAKLPQNLDKNRYKDVLPYDTTRVLL-----QGNEDYINASYvnmeIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGrtkchq
 | |. . || |||||..||||..|| |       ..||.||||    ||. .  . |||.||| . .  .||..|.... . |.|.| | |        
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasy....ipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd......

ywpdppdvmnhggfhiqcqsedctiayvsremlvtntQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD-SEPVLVHCSAGIGRTGVLVTM
                                     .  . .||.  ... |||..||  .| .|.|.. |..   . . |...|||||.|||||....
.....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisi

ETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
.. .. ...   .  ...| ..| .| .||||  || |.  |.| 
dsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 673-730 2e-07 25.1 In-house 40-95 (95) alignment 
Range on Protein: 673-730
Range on HMM: 40-95/95.0
ITFAKLPQNLDKNRYKDVLPYDTTRVLLQG--NEDYINASYVNMEipaaNLVNKYIATQG
 |      |. |||. ...|||.||| |    . ||||| .|.         | |||.||
ytvgsseanipknrflnifpydatrvvlttkrdsdyinacfvdgy....arkncyiaaqg
0042113 (Phosphotyrosine protein) phosphatases II 674-911 2.9e-80 264.5 In-house 2-241 (245) alignment 
Range on Protein: 674-911
Range on HMM: 2-241/245.0
TFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE-----DYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQY
..|.|| | |||||.|.|||| ||| |.  .     ||||||||    .  .  .|.||||||||.|.. ||. .|..... |||||...|.|| ||.||
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyv....dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqy

WPDpPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV--DSEPVLVHCSAGIGRTGVLVTM
||.  .....|.|.... ||.    |. |.. |||....|...|.|..|. ||||||||.....|.|...||. .   ...|||||||||.||||.....
wpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa

ETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
 ..... |..| . . ..|...|.|| ..||| |||.|. ||.| 
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
0040439 (Phosphotyrosine protein) phosphatases II 674-911 8.4e-79 259.9 In-house 4-244 (249) alignment 
Range on Protein: 674-911
Range on HMM: 4-244/249.0
TFAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQY
..|.|| |.|||||.|.|||| .|| |.        |||||||.    .  .  ...||||||||.|.. ||. .|... . |||||.|.|.|| ||.||
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi....dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqy

WPDpPDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRV---DSEPVLVHCSAGIGRTGVLVT
||.  .....|.|.... |..    |. |.. .||...||..||.|.||. |||||||.. .|.|.|...||. .    ...|||||||||.||||....
wpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfia

METAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
. ..... |..| . ....|...|.|| ..||. .||.|..||.|.
aylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyealle
0037934 (Phosphotyrosine protein) phosphatases II 674-910 6.5e-76 250.3 In-house 3-239 (243) alignment 
Range on Protein: 674-910
Range on HMM: 3-239/243.0
TFAKLPQNLDKNRYKDVLPYDTTRVLLQGnEDYINASYVNMEiPaanlvnKYIATQGPLPHTCAQ----FWQVVWDQKLSLIVMLTTLTERGRTKCHQYW
..|.||.||.||||.|.|||| .|| |.| .|||||.....  |      ..||||||||.|...    ||. .|... . |||||.|.|.|| ||.|||
siallpenlsknrysdilpydhsrvkleg.sdyinanliyvt.p......rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqyw

PdpPDVmNHGGFHIQCQSEDCTIAYVSREMLVTNTQ-TGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS---------LRVDSEPVLVHCSAGIGR
|   .| ..|.|.... ||  .  |. |..|..|.. ......|.|..|..||||||||. .|.|.|...||.          . ...|||||||||.||
p..gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGVLVTMETAMCLTernlPIYPLDIVRKMRDQRAM-MVQTSSQYKFVCEAIL
||.|... . . |      . ....|...|.|| . .||| |||.|. ||.|
tGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_PTPRK_pd Subfamily PTPRK 674-911 5.8e-60 197.7 In-house 36-275 (314) alignment 
Range on Protein: 674-911
Range on HMM: 36-275/314.0
TFAKLPQNLDKNRYKDVLPYDTTRVLLQGNE-----DYINASYVnmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQY
  ||  .| .|||..|.|.|| .|| |.  .     |||||...     . .  ...|.|||||..| . ||..|.|.. . ||||| |.| || || .|
daakkdenreknrsgdilaydrsrvflitidgdpssdyinaali....dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClky

WPDPPDVmnHGGFHIQCQSEDCTIAYVSREMLVTN--TQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSE-PVLVHCSAGIGRTGVLVT
||.  .|  .| ..... . .    .|.| . |..   .  | ..| ..|...||||.||     .|..|  | . . ... ...|||||| ||||. ..
WPedtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfia

METAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
... . . ||.  .    .|...|...  ||.|  ||||. ..|| 
idivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 674-911 1.4e-57 190.1 In-house 44-282 (297) alignment 
Range on Protein: 674-911
Range on HMM: 44-282/297.0
TFAKLPQNLDKNRYKDVLPYDTTRVLLQG--NE---DYINASYVNMEIPaanlvnKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRtKCHQY
| |.   |..|.|||..||||. || |.   ..   ||.|||.|.          ..|.|| | . | | ||..|.|.. | ||||. . || . || .|
tvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh......rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcary

WPDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPD--DSSDFLEFVNYVRSL-RVDSE-PVLVHCSAGIGRTGVLV
|.|   |.. |   .. .| .    .. ||. ||. ..  .. |   |.| |||. |.   . | .|.... ||      .| |.||||.||.||||||.
Wsdk.gvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvll

TMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
|..  ..  .|.  .  ...|.|.|..|  .|||  ||||| .|.| 
tidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavle
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 674-773 4e-10 33.7 In-house 89-182 (244) alignment 
Range on Protein: 674-773
Range on HMM: 89-182/244.0
TFAKLPQNLDKNRYKDVLPYDTTRVLLQG---NEDYINASYVNMEIPAAnlvnKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERgrtkcHQYWP
  |  |.|  |||    ||.|  || |      . |||||.|     .|    .|| || ||  |  .||... .... ..|.| .. |       .|||
kdafnpnnswknregaglpfdfnrvplskgsmgntyinasfvgclgrta....eyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywp

DPP
|  
dse
subfamily_PTPRA_pd Subfamily PTPRA 675-916 2.5e-62 205.7 In-house 52-298 (330) alignment 
Range on Protein: 675-916
Range on HMM: 52-298/330.0
FAKLPQNLDKNRYKDVLPYDTTRVLLQ---G--NEDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYW
 |.  .| .|||. ..|||| .|| |.   |  . ||||||...      .  .|.||.|||. .|   ||...|.|| . ||||| | || ..||.|||
laskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfid....GykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PDPpDVMNHGGFHIQCQSEDCTIAYVSREMLVT----NTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSAGIGRTGVLV
||   .. .|  ... . |  ...|  |..||.    .|.  ..  |. . . .||| ||| ..   |.... |..|. . ..|. ||||||.|||| ..
Pde.GlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfi

TMETAM--CLTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEEG
.... .    .|| . ..  ..|...| ||. ||||  ||.|. ...|  |  |
vldavlervkaerkvdvf..efvkrlrlqrpqmvqtdeqyefiykvlleyylyg
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 675-713 6.8e-06 19.7 In-house 41-84 (440) alignment 
Range on Protein: 675-713
Range on HMM: 41-84/440.0
FAKLPQNLDKNRYKDVLPYDTTRVLLQG-----NEDYINASYVN
 | ||.|  ||||...| || .||.|.      ..|||||||.|
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 676-912 4.7e-62 204.4 In-house 4-241 (250) alignment 
Range on Protein: 676-912
Range on HMM: 4-241/250.0
AKLPQNLDKNRYKDVLPYDTTRVLLQGNE-----DYINASYVNMEIPAanlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTkCHQYWP
|| |||..|||| |....| .||.|. ..     ||||||...         . .|||||||..|  .||..|...| . |||||.|.| ..| .|||||
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder....kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywP

-DPPdvMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR--VDSEPVLVHCSAGIGRTGVLVTME
 . .   ..|. ...  |..    |..|.. .....  .| .| .|..|.||| |||.     ||... |.. .  ... ||.|.||||.||.|  ....
veka..ekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaid

TAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV
. .   ...  .   ......| .|  .|.. .|| || |.||. 
avlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 676-915 4e-36 119.3 In-house 47-284 (301) alignment 
Range on Protein: 676-915
Range on HMM: 47-284/301.0
AKLPQnlDKNRYKDV--LPYDTTRVLLQGNEDYINASYVNMEipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP-DP
| ||.  ||.||. |   |  . .|. .|.   | | ... .       ...|||||||. |.  || ..   ..  ||||.   |.  .||..| | ..
aylpk..dkhryptvPckPstavevivdGkrvPihanwipts....GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvki

PDVMNHGGFHIQCQSEDCTIA--YVSREMLVTNT-QTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSlrvDSEPVLVHCSAGIGRTGVLVTMETA
.. .. | |.|. ....  .    . |.. |... .  . .|||| ||. |.|.|||    .  .... |.      .|..|||||||||.  ... |  
sekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk...sekPivvhcsaGiGrsvafigteyl

MCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFV-CEAILRVYEE
    | .  |   . ....|..|   ||| ||  ..   .. |.  |
areveadptieltealkhlrehrwngvqtnsqlywmtlGtvyrlike
subfamily_egg_pd Subfamily egg 676-913 1.9e-31 103.9 In-house 35-270 (307) alignment 
Range on Protein: 676-913
Range on HMM: 35-270/307.0
AKLPQNLDKNRYKDVLPYDTTRVLLQGN-----EDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERgrTKCHQYWP
|    ||.| | | |   |..|| |. .     .|.| | .|.       |.|..| .| ||  |  .||..|. ..   |||||.  |    .|. |||
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvk....Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

DPP-D--VMNHGGFHIQCQSEDCT---IAYVSREMLVTNTqtGEEHTVTHLQYvawpDHgvpDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLV
  . |  |.  |...|..   | .   .  |..  ||      ||  . | |.    |    . |||    .. .| ||  |.||.|..  |. ....||
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqg....dv...nnssdvysplrvlrklrnlskpvvvqdilGvskaatlv

TMETAMCLTERNlPIYPLDIVRK---MRDQRAMMVQTSSQYKFVCEAILRVY
..|.|..   |  ||.   . |    .| .| . |..  .| ||   .| ..
aieiallsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 677-911 8.5e-62 203.7 In-house 24-266 (274) alignment 
Range on Protein: 677-911
Range on HMM: 24-266/274.0
KLPQNLDKNRYKDVLPYDTTRVLLQG------NEDYINASYVNMeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP
... .  |||||..|| ...||||.       . .|||| |.       .  . |.|||||||.| |.||.... .. ..||||| |.|. ..||..|.|
dvfgsqtknryktilPnensrvllesessededssyinanyikG...ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

DPPDV---MNHGGFHIQCQSEDCTIAYVSREMLVTNTQTgeEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDS----EPVLVHCSAGIGRTGVL
|  |.    ..|...|. ..   .  |  |.... ...   |..|.|  | .|||| .||| . .|..|. |.. | ..     ||.|||||||||||. 
daedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcf

VTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
.... |.   ...  .  | || ..| .|  |||||.||... .|.  
iaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 677-915 1e-41 137.7 In-house 44-289 (305) alignment 
Range on Protein: 677-915
Range on HMM: 44-289/305.0
KLPQNLDKNRYKDVLPYDTTRVLLQGN--EDYINASYVNMeiPAAnlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPD-PP
|  |. .|||||||   |  || |.|    .|| | ||    |.    ...| || || .|||.|| . ...|.  | ||  | |.|  ||..|..    
keaqeagknrykdvgcldnnrvklegpwpheyihanyvst..ptn..pkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdk

DVMN--HGGFHIQCQSE--------DCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRslrVDSEPVLVHCSAGIGRTGVL
||..   .| .|. . |        . . | |.. .|| .   .. . |||  .. ||| |||      ||...  |   .   |. ||||||||||| .
dvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekar...pskgpivvhcsagigrtgsv

VTMETAMC-LTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYEE
| .|  .  | . .       |..|.|.||   .||  || || . ||  ...
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 678-910 1e-40 134.4 In-house 5-238 (239) alignment 
Range on Protein: 678-910
Range on HMM: 5-238/239.0
LPQNLDKNRYKDVLPYDTTRVLLQ-----GNEDYINASYVNMEIPAanlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDP
   |  |||| ... || .||.|.        |||||||.     .    . |||||| .  .. .||...|...  .||||| | |  . |||||||| 
krvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgs...pkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

pdVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS-LRVDSEPVLVHCSAGIGRTGVLVTMETAMC
    ..  ...  .  .    |. | .....    ||. | . ..  |||.|||. ..  | .   .       . | ..|||||.|||| .. ... . 
..tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlr

LTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL
 ....  .  .. |. .|..|  ||||| || |.  |.|
qakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_CG7180_pd Subfamily CG7180 679-912 4e-42 138.9 In-house 40-289 (296) alignment 
Range on Protein: 679-912
Range on HMM: 40-289/296.0
PQNLDKNRYKDVLPYDTTRVLLQ---G--NEDYINASYVNMEIPAanlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRtKCHQYWPDPP
 .|..|||. .|.||| .||.|.   |  ..|||||.||.  .      ..|| |..|  .|  .||..|.|.. | .|.||  ..  . ....|||   
kenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkk....keyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnks

dVMNHGGFHIQCQSEDCTIAYVSREMLVTNT----------QTGEEHTVTHLQYVAWPD-HGVPDDSSDFLEFVNYVRSLRVDS------EPVLVHCSAG
   ..| . ..  .|.   . ..|.. .| .           . |. .|...|.  |.  . ||  .. ..|... ||..|         .||.|..| |
.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdG

IGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILRV
 .|.|| .... .. | |..  .   . |...| .|  .|..  .||.. . .|  
asRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 679-910 8.6e-41 134.6 In-house 5-237 (239) alignment 
Range on Protein: 679-910
Range on HMM: 5-237/239.0
PQNLDKNRYKDVLPYDTTRVLLQ-----GNEDYINASYVNMEIPAanlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPp
  |  |||| ... || .||.|.        |||||||.     .    . |||||| .  .. .||...|...  .||||| | |  . ||||||||  
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgs...pkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.

dVMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRS-LRVDSEPVLVHCSAGIGRTGVLVTMETAMCL
   ..  ...  .  .    |. | .....    ||. | . ..  |||.|||. ..  | .   .       . | ..|||||.|||| .. ... .  
.tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

TERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL
....  .  .. |. .|..|  ||||| || |.  |.|
akkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 680-910 7.4e-50 164.4 In-house 2-236 (237) alignment 
Range on Protein: 680-910
Range on HMM: 2-236/237.0
QNLDKNRYKDVLPYDTTRVLLQG---NEDYINASYVNMeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVM
.|  |||| ..  || .||.|.|   . |||||.|..         .||||.||||  .| .|||.||..| |.||||| | |. . |||.|||.  .  
enkiknrygnivaydhsrvvlkgagsgsdyinatylkg...fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa

NHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTV-THLQYVAWPDHGVPDDSSDFLEFVNYV--RSLR-VDSEPVLVHCSAGIGRTGVLVTMETAMCL
 .| . .  . ..    |  | .|... .| .|  .    |. .|||.|||. .. .| |   .  ||    .| | ..|||||.||||... ... .  
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

TERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL
.. .  .   . |  . ..|  ..||  || |. ..||
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 680-910 1.6e-33 111.0 In-house 42-268 (288) alignment 
Range on Protein: 680-910
Range on HMM: 42-268/288.0
QNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVnmeIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDP-PDVMNH
.|  ..||...   |.||| |. . |.  |. |   ...|.  .. | .| ||  |  ..|... .. .  ||||. | |.|. |  .|.|    . .  
anptrdryenlprcditrvklsddpdfyiaanv...vssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

GGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHT-VTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLrvdSEPVLVHCSAGIGRTGVLV--TMETAMCLTER
| .  . . .   |  . .  |. ....|||.  | .| .  |.|.|||..   .| ... ..||    .|..||.|||.|||| |.   .   .   . 
grlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlksl...qkPivvhssaGvGrtgtlililialeslrldd

NLPIYPLdiVRKMRDQRAMMVQTSSQYKFVCEAIL
.| | .|  . |.|..|   .||  || .|   .|
flgirsl..laklreerfkaiqtemqylyvhrcvl
subfamily_ptpA1_pd Subfamily ptpA1 680-868 2.7e-32 107.0 In-house 46-251 (418) alignment 
Range on Protein: 680-868
Range on HMM: 46-251/418.0
QNLDKNRYKDVLPYDTTRVLLQGNEDYINASYVNMEIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPD-----
.|  |||| ..|| . ||| |.  .|   . |.| .       ...|.|||||| | |.||..||...  .||||.  .|  | || .|||.        
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfs

VMNHGGFHIQCQSED--CTIAYVSREMLVTN---TQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR---V----DSEPVLVHCSAGIGRTGV
.   |   .   | .    |    ||..  |   |  || . .|. ||  |||| .|| .  | ...  .   .   .       |..||||||.|||| 
iygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgt

LVTMET
..|   
fctavi
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 680-919 4.5e-30 99.6 In-house 32-264 (267) alignment 
Range on Protein: 680-919
Range on HMM: 32-264/267.0
QNLDKNRYKDVLPYDTTRVLLQG-NEDYINASYVNmeipAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLterGRTKCHQYWPDP-PDVMN
.| ..||. |.|||| ||| |.  .|.|||||||.    . .  |..|.||.||  | ..|..|. |||.. ||.||.    .  . ...||    .  .
knqernrlddnlpyddtrvilrtkeeeyinasyve....gyktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnirlfwPPkmgqakk

HGGFHIQCQ--SEDCTIAYVSREMLVTNTqtgEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMC--LT
.  . ..     |.     .. |. . |      | ||   |  |            |  .     |   . |..|.||.|.||.| ...... .    |
yqdltvehslekeendyqiitlelkfkne...sahnvtlyyykkwnintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflvidsqlerakt

ERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAiLRVYEEGLVQ
|  . |.  | .||.|.||  .|.|  .| .. |  |  | || ..
egvsdif..dflrkirsqriglvdtkeryiyihel.laeyaegrlk
Y_phosphatase Protein-tyrosine phosphatase 681-910 6e-81 266.7 Pfam-A 1-234 (235) alignment 
Range on Protein: 681-910
Range on HMM: 1-234/235.0
NLDKNRYKDVLPYDTTRVLL---QGNEDYINASYVNMEIPaanlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP-DPPDVM
|..||||||.|||| ||| |   .|..|||||.||..        .|.|||||||..|...||..||..| ..|||||.|.|.||.||.|||| .  . .
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke....kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

NHGGFHIQCQ--SEDCTIAYVSREMLVTNTQTG-EEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSAGIGRTGVLVTMETAMCL
..| ......  ... . .|. |.. ......  |...|..|.| .|||||||......|.... |.. .  .|.||.||||||.||||..|....... 
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

TERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL
 |..  .  |.||...| ||..|||. .||.|...|||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 681-910 6e-81 266.7 In-house 1-234 (235) alignment 
Range on Protein: 681-910
Range on HMM: 1-234/235.0
NLDKNRYKDVLPYDTTRVLL---QGNEDYINASYVNMEIPaanlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWP-DPPDVM
|..||||||.|||| ||| |   .|..|||||.||..        .|.|||||||..|...||..||..| ..|||||.|.|.||.||.|||| .  . .
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyke....kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

NHGGFHIQCQ--SEDCTIAYVSREMLVTNTQTG-EEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSAGIGRTGVLVTMETAMCL
..| ......  ... . .|. |.. ......  |...|..|.| .|||||||......|.... |.. .  .|.||.||||||.||||..|....... 
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

TERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL
 |..  .  |.||...| ||..|||. .||.|...|||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 681-911 8.5e-61 200.3 In-house 20-262 (270) alignment 
Range on Protein: 681-911
Range on HMM: 20-262/270.0
NLDKNRYKDVLPYDTTRVLLQGN-----EDYINASYVNmeiPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDV
.   |||.|.||  .||| |.         |||| ||.    . .  .||||..|||| |  .||...|..| . |||.| |.|.||.|| .|||  |. 
gkklnRyadiLPsPatRvrleeleedsataYinAnyvr...GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepke

---MNHGGFHIQCQSEDCTIAYVSREMLVTntQTGEEHTVTHLQYVAWPDHGVPDDSS------DFLEFVNYVRSLRVDS---EPVLVHCSAGIGRTGVL
   ...|  ..  .||  .  |. ... ..  ..|||. ..| .|..||||||| ..       . |. .. ||  . .    ||.|||||||.||||.|
kvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

VTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
.....|..| |..  . .| |....| .|  .||.. ||.|. .|.. 
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 681-911 4.2e-52 171.6 In-house 56-281 (290) alignment 
Range on Protein: 681-911
Range on HMM: 56-281/290.0
NLDKNRYKDVLPYDTTRVLLQ--GNEDYINASYVNmeipaaNLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDP-PDVMN
.. |||||||   | |||.|.  .. ||. | ||.       |   .| |||.|  |  ..|..| ..| . ||||  | | |..||.||.|.   .|. 
efkknrykdvvcndktrvilkdGydGdyvhanyvk......GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

HGGFHIQCQSEDCTIAYVSREML-VTNTQTGEEHTVTHLQYVAWPDHGVPDDSsdfLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAM-CLTEr
 | . . |  ||   | . . .| | . ..| || . ||. ..|||. |.  .   | ..  .|.||  | || ||||||||||| .|..|... .|.. 
fGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalst...lallrtlrilrkasGpvvvhcsaGiGrtGtfvaievglqilld.

NLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
   . .||.|| .|. |.  ||   ||  . |..| 
Gkeldlldlvralrnsrlnsvqvdiqylalveilld
0041856 (Phosphotyrosine protein) phosphatases II 681-914 1.1e-51 170.4 In-house 1-172 (182) alignment 
Range on Protein: 681-914
Range on HMM: 1-172/182.0
NLDKNRYKDVLPYDTTRvllqgNEDYINASYVNMEIPAANlvnkYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTtltergrtkCHQYWPdppdvmnhgg
|||||||.|.|||| .|     . |||||... .  || .    .|||||||..|.|.|.. ..... ..||.||         ...|||          
nldknrysdilpydhsr.....dldyInanlylgslpatr....fiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

fhiqcqsedctiayvsremlvtntqTGEEHTVTHLQYVAWPDHGVPDdSSDFLEFVNYVRSlrvDSEPVLVHCSAGIGRTGVLVTMETAMCLternlPIY
                         . .|.......|. ||||||||  ...|.|.. |..   ...|||||||||.||||.|| .   ..|      . 
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle...eggpvlVHCsaGvgRtgtlvaaylmkkl.....gvs

PLDIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE
. ..|. .| .| .||.| .|| |.  |.| ...
leeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 681-914 5.6e-40 131.9 In-house 55-290 (305) alignment 
Range on Protein: 681-914
Range on HMM: 55-290/305.0
NLDKNRYKDVLPYDTTRVLLQG--NEDYINASYVNMEIPAAnlvNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPP--DVM
.  ||||.||   | . |.|.     ||| | ||   .      ...|..|||| .|  .|| .| ..|.  ||||    | |. || ||||      . 
aitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipe...krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

NHGGFHIQCQSEDCTIAY---VSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVdsePVLVHCSAGIGRTGVLVTMETAMCLT
 ..|  ..  |    .     .   .|  .   ... .| |||.  ||| |||      ||..  .|  .|   |..||||||||||| .|..|  .   
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgskv...pivvhcsagigrtgtivaieyileki

ERNLPIYPL-DIVRKMRDQRAMMVQTSSQYKFVCEAILRVYE
  | |  |. ..|. .|||||. .|.  || |.   .|  . 
aenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_CG42327_pd Subfamily CG42327 681-840 8e-23 75.6 In-house 28-191 (319) alignment 
Range on Protein: 681-840
Range on HMM: 28-191/319.0
NLDKNRYKDVLPYDTTRVLLQGN-----EDYINASYVNMEIPAanlVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDV
  ||.|. .|.|   ||| ||       . |..||||     |    | |||.| .|  . ..||..||.|.   || || | | |  .| .|.|     
skdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGydda...pnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketl

M---NHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYvAWPDHGVPDDSSDFLEFVNYVR
     .| . .  .  .    |.   .|. . .  |   .||  |  |.. .|| . . ..  .  ||
dntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 682-771 5.9e-26 86.0 In-house 48-152 (350) alignment 
Range on Protein: 682-771
Range on HMM: 48-152/350.0
LDKNRYKDVLPYDTTRVLLQ-------------GNEDYINASYVNMEIPAANLVN--KYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCH
  |||||..|||. .|| |.               .|||||.|.... .. .     ||||||.||| |  .|..|.   |  .|..||.. | .. ||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPD
.||..
rYWqe
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 683-917 3.5e-32 106.4 In-house 45-281 (312) alignment 
Range on Protein: 683-917
Range on HMM: 45-281/312.0
DKNRYKDVLPYDTTRVLLQGNED-YINASYVNMeipaANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVMNHGGF
| ||| ..  .|  |  | |.|. || | .|..        .....|||||  ||..|||..     . |..|... | |  || .|  |    ..    
dlnrypniqcwdrgrftlagdenfyihanfvki....ctkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

HIQcqSEDCT---IAY------VSREMLVTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNyvrSLRVDSEPVLVHCSAGIGRTGVLVTMETAMCL
 .   .| ||   |          | . |    ||.|  . | |. .|||||.||     | ..    ... |  ||. |||||.|||| |. .|. .. 
rvy..teycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrlls...avkkdkkpviahcsagvgrtgtlaliesmiaa

TERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR-VYEEGL
          |.   .| .||  |..  || ..  ..|  .| .||
lrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 691-825 6.2e-09 30.3 In-house 3-126 (130) alignment 
Range on Protein: 691-825
Range on HMM: 3-126/130.0
LPYDTTRVLlqgNEDYINASYVNMeipaANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERgrtkcHQYWPDPPDVMNHGGFHIQCQSEDC
|... .|.    ...|||||.| .     .  ..|. || ||  |. .||... .. . ..|.| .. |       .||||   .  .    |   ..  
lefevsrlq...gntyinasfvGl....lgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrd

TIAYVSREMLVTNTQTGEEH-TVTHLQYVAWPDHGV
   ..  . |  . .  | | ..| .|   ||  | 
efknikasnleiesdlneshqaltmfqisnwpsdgt
0044763 (Phosphotyrosine protein) phosphatases II 692-914 3.8e-36 119.8 In-house 1-172 (178) alignment 
Range on Protein: 692-914
Range on HMM: 1-172/178.0
PYDTTRVLLQGNED-----YINASYVNmeipaANlvnKYIATQGPlphtcAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDvmnhggfhiqcq
|.| |||||.  |.     |||||..       .    |.....|     |.... ........||.||. .|.|. ||..|||.  .            
pldrtrvllsnleglersdyinaseil.....pg...lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag............

sedctiayvsremlvtntqtgeehtvTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLR-VDSEPVLVHCSAGIGRTGVLVTMETAMCLternlPIYPLDIV
                           . ... .||||||| .. |||||.......  . .|||||||||.||.|.|| .   ..|      . . ...
..........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeai

RKMRDQRAmMVQTSSQYKFVCEAILRVYE
. .| .|  .|.. .|.....|  ||...
elvrerRp.ivpnpgqlrqLyefelrllk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 696-910 5.2e-27 89.7 In-house 33-256 (290) alignment 
Range on Protein: 696-910
Range on HMM: 33-256/290.0
TRVLLQG-----NEDYINASYVNMeiPaANLvnKYIATQGPLPHT-------CAQFWQVVWDQKLSLIVMLTTLTERGRT----KCHQYWPDPPD-VMNH
||| |.|     |.||| |..| .  |  .|  . |.|| |. ..         .|| .. . |   .|||   .|. .      | .| |.  .  .. 
trvvLkgygkrfnddyiHAnrvtc..p.ngl..rliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkf

GGFHIQCQSEDCTIAYVSREMLVTnTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRslrVDSEPVLVHCSAGIGRTGVLVTMETAMCLT-ERNL
.|. ..|.|         ||..|.  . .||.|||| ... | .  |..|.  .|. ...|.       ||.|||  || |  .| ... .. .  | . 
kgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvk...asktpvivHcvdGiSrsAalaaiilgyQkiaetsg

PIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAIL
 .   |.. ..| |||.....  .. ||  .|.
svkledvlkalrkqralaitsalelafvdagiv
0046846 (Phosphotyrosine protein) phosphatases II 700-912 5.9e-46 151.7 In-house 8-172 (176) alignment 
Range on Protein: 700-912
Range on HMM: 8-172/176.0
LQGNEDYINASYVNMEipaanlvnKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDppdVMNHGGfhiqcqsedctiayvsrem
|... |||||... .         ..||||||||.|.|.|.. ..... ...|.||...| || ||..|||.   ....|                    
ldldldyinanlilgs........rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi...................

lvtntqtgeehtvtHLQYVAWPDHGVPDDsSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMEtamcLTERNLPIYPLDIVRKMRDQRA-MMVQT
              . ... ||||||||. ...||.....|. . . .||||||||||||||.|| .     | |..  . ........|.||  ..|||
..............qylhlpwpDhgvpdl.elllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqt

SSQYKFVCEAILRV
 .||.|. |..|..
peQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 703-906 5.7e-46 151.7 In-house 4-154 (172) alignment 
Range on Protein: 703-906
Range on HMM: 4-154/172.0
NEDYINASYVNMEIpaanLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLtergrtkchqywpdppdvmnhggfhiqcqsedctiayvsremlvT
..|||||||... .      ...|||||||..|.|.||. ..... ..||.||.|                                            .
gsdyinasyldlyy....ipdrfiatqgplrntladfwrmlkelgithivnltel............................................l

NTQTGEEHTVTHLQYVAWPDHGVPdDSSDFLEFVNYVRS--LRVDSEPVLVHCSAGIGRTGVLVTMETAMclternLPIYPLDIVRKMRDQRAMMVQTSS
.. ...|... ...|. ||||||| ... .|||......  .. ...|||||||||.||||.|| .   .      | . ....|. .|..| ..||. |
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYKFVC
||.|..
qyrfly
0051429 (Phosphotyrosine protein) phosphatases II 704-914 1.9e-53 177.2 In-house 4-226 (272) alignment 
Range on Protein: 704-914
Range on HMM: 4-226/272.0
EDYINASYVNMEiPAANLVNKYIATQGPLPHTCAQFWQVvWDQKLSLIVMLTTLTERGRTKCHQYWP-----------DPPDVMNHGGFHIQCQSEDCTI
..||||..|..      . .......||||.|.|.||.  ...... ||.|....|||| ||..|||           | .  ...| ... ..|| .. 
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

AYVSREMLVTNT-QTGEEHTVTHLQYVAWPDHGVPDDSsdFLEFVNYVRSlrvdSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIY--------PLD
 |. ||.|.|.. ..|| ..|.||.| .|||||||...  .||.......    ..|||||||||..|||..| .   .   ...  .         ...
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlylee

IVRKMRDQRAMMVQTSSQYKFVCEAILRVYE
.|...|.||. .|||  ||.|..||.| ...
aveelraqrpgavqteeqylflyeallellr
0036282 (Phosphotyrosine protein) phosphatases II 704-906 5.3e-47 155.0 In-house 2-163 (174) alignment 
Range on Protein: 704-906
Range on HMM: 2-163/174.0
EDYINASYVNMEIPAAnlvnKYIATQGPLPhtcaqFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDppdvmnhggfhiqcqsedctiayvsremlvtn
.||||||.... .       ..||.||||.     ||. ....... .|||... |.|..||..|||.                                
sdyinaspldlsyitp....rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................

TQTGEEHTVTHLQYVAWPDHGVPDDSSdFLEFVNYVRSLRVD--SEPVLVHCSAGIGRTGVLVTMETAMCLTErNLPIYPLDIVRKMRDQRAMMVQTSSQ
... .|... ...|. ||||||||.|  .||||..|.. . .  . |||||||||.||||.|| .   ... . . ..  ||.||..| || .|||| ||
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YKFVC
|.|. 
yrfly
0051082 (Phosphotyrosine protein) phosphatases II 704-908 2.3e-33 110.3 In-house 3-148 (151) alignment 
Range on Protein: 704-908
Range on HMM: 3-148/151.0
EDYINASYVNmeiPAanlvnkYIATQGPLPhtcaQFWQVVWDQKLSLIVMLTTLTERGrtKCHQYWPDPPdvmnhggfhiqcqsedctiayvsremlvtn
.||||.|||    .       .....|||.    .|.. ....... ||.|....|||  .|..|.|.                                
sdyinfsyvt...gg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..............................

tqtgeeHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSlrVDSEPVLVHCSAGIGRTGVLVTMETAMcLTernlpIYPLDIVRKMRDQRAMMVQTSSQYK
      ..|.|.... |||.|.|.    .|||......   .. |||||||||.||||.|| .   . |      . . .... .| .| ..||.. |. 
......ievlhipildwpdpglplsfdavleflellld..kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqqfl

FVCEA
|.  |
fqlfa
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 704-795 3.7e-14 46.8 In-house 90-175 (349) alignment 
Range on Protein: 704-795
Range on HMM: 90-175/349.0
EDYINASYVNmeIPAANLVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDppdvMNHGGFHIQCQSEDCTIAYV
.||||| |..  ..  .  .|||||| ||| |   |..|.  ... |.. |.   | .  ||..|| .    ... ..... |     || |
ddyinanylk..ltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe....lsysnitvklqnsslyianv
0049260 (Phosphotyrosine protein) phosphatases II 721-906 1.6e-41 136.8 In-house 7-143 (152) alignment 
Range on Protein: 721-906
Range on HMM: 7-143/152.0
LVNKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWpdppdvmnhggfhiqcqsedctiayvsremlvtntqtgeehtvtHLQYVAW
  ...||||||.|.|.|.||. ..... . |||||.|.|.|. ||.||.                                            . ... |
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpw

PDHGVPDDSSDFLEFVNYVRS-LRVDSEPVLVHCSAGIGRTGVLVTMETAMclternLPIYPLDIVRKMRDQRAMMVQTSSQYKFVC
|||||||.|  .|...  ..  .. ...|||||||||.||||.|| .   .      | . ....|. .| .| ..|.. .|..|. 
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 723-905 2.6e-17 57.6 In-house 4-195 (198) alignment 
Range on Protein: 723-905
Range on HMM: 4-195/198.0
NKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPD-VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEH--TVTHLQYVA
 .||||| || .| |.|||.||.     |||.        .    |||     . ..| . . ...  .   |.   ...||  |       ..| |. .
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDdSSDFLEFVNYVRSLRVD-----SEPVLVHCSAGIGRTGVLVTMETAMCLTERN-LP-IYPLDIVRKMRDQRAMMVQTSSQYKFV
| ..  |.  . |. ||   | .          ||.|||| | | |||.|...  .   |      .  ... ...|. |  .. .  .|.|.
wkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 723-905 2.7e-17 57.6 In-house 5-196 (199) alignment 
Range on Protein: 723-905
Range on HMM: 5-196/199.0
NKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPD-VMNHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEH--TVTHLQYVA
 .||||| || .| |.|||.||.     |||.        .    |||     . ..| . . ...  .   |.   ...||  |       ..| |. .
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPDdSSDFLEFVNYVRSLRVD-----SEPVLVHCSAGIGRTGVLVTMETAMCLTERN-LP-IYPLDIVRKMRDQRAMMVQTSSQYKFV
| ..  |.  . |. ||   | .          ||.|||| | | |||.|...  .   |      .  ... ...|. |  .. .  .|.|.
wkekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 723-783 2.2e-08 27.8 In-house 236-293 (440) alignment 
Range on Protein: 723-783
Range on HMM: 236-293/440.0
NKYIATQGPLPHTCAQFWQVVWDQKLSLIVMLTTLTERgrtKCHQYWPDPPDVMNHGGFHI
| .|||| ||  |  .||..| | ..| |.||  | ..    |  |||     .  | | .
nafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 727-907 6.8e-21 69.5 In-house 39-215 (255) alignment 
Range on Protein: 727-907
Range on HMM: 39-215/255.0
AtqgplphTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVM-NHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGV
        | ..|.|..  .| . .|||. ..| |. ||..|.|   |         . .      .    .|.. | ..  . |||.| .|  |...  
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWiekna

PDDSSDFLEFVNYVRslrvDSEPVLVHCSAGIGRTGVLVTMETAMC---LTER---NLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCE
|... . |. .  ||    || .|.||||.||||.  .| .| .     .. .      .  | .....| .|.  ..|  |  |   
Pelareilnilkvvr....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsil
subfamily_hpo-7_pd Subfamily hpo-7 727-905 8.5e-18 59.2 In-house 42-219 (263) alignment 
Range on Protein: 727-905
Range on HMM: 42-219/263.0
AtqgpLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDPPDVM-NHGGFHIQCQSEDCTIAYVSREMLVTNTQTGEEHTVTHLQYVAWPDHGV
     |  | ..|.| .  .| . .|||.  .| |. || .|.|   |         . .      .   ..|.| |  .  . |||.| .|. |...  
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWieknd

PDDSSDFLEFVNYVRslrvDSEPVLVHCSAGIGRTGVLVTMETAMCLTER------NLPIYPLDIVRKMRDQRAMMVQTSSQYKFV
| .. . |. .. .|    .| .. ||||.||||.   . .|..     |         .  | .....| .|.  ..|  |  | 
pelareilnilkvar....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafs
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 730-906 8.4e-23 75.3 In-house 98-281 (302) alignment 
Range on Protein: 730-906
Range on HMM: 98-281/302.0
GPLPHTCAQFWQVVWDQKLSLIVMLTTLTERGRTKCHQYWPDP-PDVMNHGGFHIQCQSEDCTIAYVS-------REMLVTNT--QTGEEHTVTHLQYVA
 |   |. ..| .. . . ...| |... | .  || .|. |   .... | . ..  | .  ..  .         . ..|.  ..  ..||  |.. |
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsa

WPDHGVPDDSSDFLEFVNYVRSLRVDsepVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVC
||||| |...   |. ...  | . .   ||||||||.|||| ||..   . |  ..     |.||  .|. |   ||. .|  .. 
wpdhGapkeaytaldilkfcesykkn...vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
0048179 (Phosphotyrosine protein) phosphatases II 781-907 9.7e-26 85.6 In-house 31-139 (144) alignment 
Range on Protein: 781-907
Range on HMM: 31-139/144.0
FHIQCQSEDCTIAYVSREmlvtntqtgeehtVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMcltERNlpIY
 .. . .|..  ... ||             ....... ||||||||.....|||........ ...|||||||||.||||.||..   .   ...  . 
ttvinlteeyepeflere.............giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk...klg..ls

PLDIVRKMRDQRAMMVQTSSQYKFVCE
. .... .| .| ..|.. .|..|..|
leealalvrsrrpgavpnpgqlrfLle
0048076 (Phosphotyrosine protein) phosphatases II 795-911 4.1e-28 93.3 In-house 36-141 (145) alignment 
Range on Protein: 795-911
Range on HMM: 36-141/145.0
VsremlvTNTQTGEEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMClternLPIYPLDIVRKMRDQRAM
.      |......|.......|. ||||||||.....|||........ . .|||||||||.||||.|| .   ..     | . . ......| || .
l......tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpg

MVQTSSQYKFVCEAILR
.|.. .|..|..|..|.
avpnpgqlrflyefele
subfamily_PTPMT1_pd Subfamily PTPMT1 799-892 8.4e-07 23.6 In-house 61-151 (171) alignment 
Range on Protein: 799-892
Range on HMM: 61-151/171.0
MLVTNTQTGEEHTVTHLQYvAWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTmetAM-CLTERNLPIYPLDIVRKMRDQR
.|. .|.. ... |..||. | .|.    |  . .. |..... . . . | ||| || ||.. ||.   .   ..|.  |   |....| |.. 
alansteewkklgveqlql.atvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlva...cylmkkeklspeeAlkalkkkRkii
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 801-912 9.7e-13 42.5 In-house 207-343 (350) alignment 
Range on Protein: 801-912
Range on HMM: 207-343/350.0
VTNTQTgEEHTVTHLQYVAWPDHGVPDDSSDFLEFVN-----------YVRSLRVDSEPVLVHCSAGIGRTGVLVTMETAMC-------LTERNLPIY--
.| . . . . | .||.  |.| ..  .  ..|. ..              .    |.|.|||||||.||||.|||..  .        ||..   .   
itlaas.dPyvvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldva

--P----LDIVRKMRDQRAMMVQTSSQYKFVCEAILRV
         || ..| ||  |||.  |. |. ||.|  
aktrDlisiivnelrkqrismvqnldqfifiYeallfy
PTPc_motif_SM00404 807-878 5.4e-07 24.6 In-house 42-109 (140) alignment 
Range on Protein: 807-878
Range on HMM: 42-109/140.0
GEEHTVTHLQYVaWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTMEtamCLTERNLP
 |.  ...||.    |... . | .. . ...... . . . ||||| ||. |.. |....   ....|.| 
kensgfqilqip.lddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY...lmryrqls
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 808-912 1.6e-17 58.0 In-house 87-193 (440) alignment 
Range on Protein: 808-912
Range on HMM: 87-193/440.0
EEHTVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSL--RVDSEPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFV
| .|. . .| .|||.|||  ..  |.... |     .. . |.||||||| |||||...... .  ..|.  |  . ..  ||..|  ||||  || ||
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

CEAILRV
 ||.|  
heavleg
DSPc Dual specificity phosphatase, catalytic domain 809-865 9.1e-08 27.0 Pfam-A 37-92 (133) alignment 
Range on Protein: 809-865
Range on HMM: 37-92/133.0
EHTVTHLQYVaWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVT
.   ..|..    |.   . |... | |....... . . ||||| ||| |.. |..
kseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii
DSPc Dual specificity phosphatase, catalytic domain 809-865 9.1e-08 27.0 In-house 37-92 (133) alignment 
Range on Protein: 809-865
Range on HMM: 37-92/133.0
EHTVTHLQYVaWPDHGVPDDSSDFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVT
.   ..|..    |.   . |... | |....... . . ||||| ||| |.. |..
kseieylrip.vedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii
PTPc_DSPc_SM00012 811-910 1e-32 107.8 In-house 1-104 (105) alignment 
Range on Protein: 811-910
Range on HMM: 1-104/105.0
TVTHLQYVAWPDHGVPDDSSDFLEFVNYVRSLRVDS---EPVLVHCSAGIGRTGVLVTMETAMCLTERN-LPIYPLDIVRKMRDQRAMMVQTSSQYKFVC
||.|..| .|||||||..|...||....|.. . .|   .||.||||||.||||..|.......  |..   .  ..||...|.||. ||||  || |..
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

EAIL
.|.|
rall
PTEN_1 812-903 3.6e-11 38.2 In-house 92-183 (196) alignment 
Range on Protein: 812-903
Range on HMM: 92-183/196.0
VTHLQ--YVAWPDHGVPDDSSDFLEFVNYVRSLRVDS--EPVLVHCSAGIGRTGVLVtmetAMCLTERNLpIYPLDIVRKMRDQR-AMMVQTSSQYK
  ...   . ..|||.|. |. | . ..   .|. |.  . ||||| ||.||.|..|    |..| ...    . . .. .|..| .......|| .
ksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv....aayLmykgk.ltadeAlelvrekRppgapnspsqer
subfamily_PTPDC1_pd Subfamily PTPDC1 812-907 8e-10 33.4 In-house 83-170 (182) alignment 
Range on Protein: 812-907
Range on HMM: 83-170/182.0
VTHLQyVAWPDHGVPDdSSDFLEFVNYVrSLRVDSEPVLVHCSAGIGRTGVLVTmeTAMCLTERnlpIYPLDIVRKMRDQRAMMVQTSSQYKFVCE
... . ..|.|.||.      |. |  | .  .. . | ||| || ||||||..  . .  ..|   . . . ....|..|.  .|| .| ..| |
iyvyn.fgwkDygvas.leriLdivkvv.afalqegkvavhChaGlGrtGvlia..cylvyakr...ltaekaiklvrskrpksiqtreqvelvke
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 812-911 3.7e-09 30.4 In-house 220-342 (349) alignment 
Range on Protein: 812-911
Range on HMM: 220-342/349.0
VTHLQYVAWPDHGVPDDSSDFLEFVNyVRSL------------RVDSEPVLVHCSAGIGRTGVLVTMETAMCL----TER----NLPIYPLD----IVRK
.  ||.  |.| ..  .   .|. .. |..               .. ..||||||| ||||||||..  . .    ..     .|.    |    || .
llqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

MRDQRAMMVQTSSQYKFVCEAILR
.| ||  |||  .|. .. ||.|.
lrkqrismvqnlaqfiaiyealLk
0038934 (Phosphotyrosine protein) phosphatases II 815-905 7.5e-10 34.3 In-house 82-169 (194) alignment 
Range on Protein: 815-905
Range on HMM: 82-169/194.0
LQYVAWPDHGVPDDSSDFLEFVNYVRSLRVD--SEPVLVHCSAGIGRTGVLVtmetAMCLTERnLPIYPLDIVRKMRDQRAMMVQTSSQYKFV
     .||.|.. . .  |.|.. |     .  .. |.||| ||.||||.||    |  | .| | . . . .. .|. |  .... .... .
ylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlv....aaYLiyr.lgmsaeeAialfrekRpgaipnqdyleal
subfamily_CDKN3_pd Subfamily CDKN3 817-907 4e-06 20.5 In-house 104-190 (202) alignment 
Range on Protein: 817-907
Range on HMM: 104-190/202.0
YVAWPDHGVPDDSSdFLEFVNYVRSLRVDSEPVLVHCSAGIGRTGVLVTmETAMCLTERNLPIYPLDIVRKMRDQRAmmVQTSSQYKFVCE
.   .| .||| .|  |.... .|    .    ||||  |.||. ....    . | .   |   .| .|...  ||  .||  || .. |
hypiadglvpdias.clkileelrinlkayrktlvhcygglgrsslvia.clllylddtiepkdaidklrdlkgsra..iqtvkqynylse
PTPlike_phytase Inositol hexakisphosphate 818-866 3.8e-06 21.6 Pfam-A 98-144 (149) alignment 
Range on Protein: 818-866
Range on HMM: 98-144/149.0
VAWPDHGVPDDsSDFLEFVNYVRSLrVDSEPVLVHCSAGIGRTGVLVTM
.. .|.  |.. .|. .||....||  ... ....|.|| ||| . ...
ipitdeqapee.edvDafvrliksl.prdtalvfnCqaGrgRTTtamvi
PTPlike_phytase Inositol hexakisphosphate 818-866 3.8e-06 21.6 In-house 98-144 (149) alignment 
Range on Protein: 818-866
Range on HMM: 98-144/149.0
VAWPDHGVPDDsSDFLEFVNYVRSLrVDSEPVLVHCSAGIGRTGVLVTM
.. .|.  |.. .|. .||....||  ... ....|.|| ||| . ...
ipitdeqapee.edvDafvrliksl.prdtalvfnCqaGrgRTTtamvi
subfamily_CG42327_pd Subfamily CG42327 844-908 4.7e-10 33.6 In-house 245-310 (319) alignment 
Range on Protein: 844-908
Range on HMM: 245-310/319.0
VDSEPVLVHCSAGIGRTGVLVTMETAMCLTERN-LPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEA
 .  |. |||| |.||||.... . |.   | .   .   ..|  .| .||  |.|  ||.|.   
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 847-911 1.4e-14 48.6 In-house 229-293 (297) alignment 
Range on Protein: 847-911
Range on HMM: 229-293/297.0
EPVLVHCSAGIGRTGVLVTMETAMCLTERNLPIYPLDIVRKMRDQRAMMVQTSSQYKFVCEAILR
 ..|||||||.||.||.|  .. .  . ..       |....|.|||..|||  |.... .|.|.
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 850-910 5.9e-08 27.0 In-house 2-62 (69) alignment 
Range on Protein: 850-910
Range on HMM: 2-62/69.0
LVHCSAGIGRTGVLVTMET--AMCLTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAIL
.||||.| |||| ....    |   .|. . |.  . |. ||  | |||    .| |. .|. 
vvhcssgtgrtgtfiaimvemarikseklvdif..nnvqymrkcrpmmvmneieyifihdalv
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 851-910 8.2e-08 26.5 In-house 2-61 (69) alignment 
Range on Protein: 851-910
Range on HMM: 2-61/69.0
VHCSAGIGRTGVLVTM--ETAMCLTERNLPIYplDIVRKMRDQRAMMVQTSSQYKFVCEAIL
||||.| |||| ....  | |   .|. . |.  . |. ||  | |||    .| |. .|. 
vhcssGtGrtGtfiaimvemarikseklvdif..nnvqymrkcrpmmvmneneymfihdalv