Gene PTPN4 in Homo sapiens

Synonym: MEG, PTPMEG, PTPMEG1, PTPN4

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN3
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP081_AA protein Get Run
HsapP081_AA_637-913 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
FERM_N FERM N-terminal domain 33-111 3.1e-25 78.3 Pfam-A 1-80 (80) alignment 
Range on Protein: 33-111
Range on HMM: 1-80/80.0
ILLLDNTVQAFKVNKHDQGQVLLDVVFKHLDLTEQDYFGLQLADDSTDNPRWLDPNKPIRKQLKR-GSPYSLNFRVKFFV
. |||.||  ..|.... |.|||. |.|.| ||| .||||.  .|. .. .|||..| .|.|... | |. | .||||.|
VrlLDgtvkevtvddsktgavlletVckrlglteteyFgLafkedkknesnwLdhdktlreqgveegkpttlllrvkfyv
FERM_M FERM central domain 113-222 3.5e-27 85.2 Pfam-A 1-126 (126) alignment 
Range on Protein: 113-222
Range on HMM: 1-126/126.0
DPNKLQEEYTRYQYFLQIKQDILTGRLPCPSNTAALLASFAVQSELGDYD-QSENLSGYLSD---YS----FIP--------NQPQDFEKEIAKLHQQHI
|||....| .......|.|.|.|..||.|. ..|.|||. ..| |.||.. .... |..| .   ..    ..|        .. ...|..|.. |... 
dpnpkydevrinllYeQakwdlleerldcteeeallLAALqlqiekgdseeeekasssdlekeeeeaeseqllpvsprllkkekskqleqrileahknva

GLSPAEAEFNYLNTARTLELYGVEFH
|||.|||. .||..|..|. |||...
glslaeaklkylqaaqslpdyGvslF
FERM_C FERM C-terminal PH-like domain 226-313 7.4e-28 87.0 Pfam-A 1-87 (90) alignment 
Range on Protein: 226-313
Range on HMM: 1-87/90.0
DQSNNEIMIGVMSGGILIYKNRVRM--NTFPWLKIVKISFKCKQFFIQLRKelhESRETLLGFNMVNYRACKNLWKACVEHHTFFRLDRP
.........|| . |.|||... ..  ..||| .| |.||| |.|.|.||.   |.....| |.. ..|..|.|.| |.|.|..||  |.
nkkgtdllLGvdakGlliyeknsklsnksFpWseirklsfkekkftiklrd...ekkkdvlkFyssqlrvnklllklcienhdlfrrrrk
FA FERM adjacent (FA) 323-364 1.6e-18 55.3 Pfam-A 2-43 (47) alignment 
Range on Protein: 323-364
Range on HMM: 2-43/47.0
HYFTLGSKFRYCGRTEVQSVQYGKEKANKDRVFARSPSKPLA
..|.|||||||.|||| |.... .|.  |.. |.|||||  .
kffslGSkFRYSGRTekQvieesreigrkppsfeRspskryl
PDZ PDZ domain (Also known as DHR or GLGF) 518-601 1e-22 70.3 Pfam-A 2-80 (81) alignment 
Range on Protein: 518-601
Range on HMM: 2-80/81.0
IRMKPDENGRFGFNVKGGYDQK-MPVIVSRVAPGtPADLCVPrLNEGDQVVLINGRDIAEHTHDQVVLFIKASCErhsgELMLLV
........|..||..||| |.. ....||.| || .|. . . |.|||... .||.|.....||..|..|| ...    |. |..
vslekekrgglGfslkggsdkrdkgifvsevvpg.gaaeadg.lkeGDkIlsvNgvdvenvshdeavqaikgkkg....evtLti
0050432 (Phosphotyrosine protein) phosphatases II 622-913 1.2e-100 332.1 In-house 11-300 (308) alignment 
Range on Protein: 622-913
Range on HMM: 11-300/308.0
YIPEKAPLDSVHQDDHSLRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIpsSSIIN
... . .  .|.  ..|. . . .| . | .| . ..| .|...|| ...|.|.||.|..||||.|| ||| .||.|... |||||.|... .  | . .
lllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgys..sklpr

QYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEP--TGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWP
..||.|||||.|. |||.| |||.....||||. ||.||.||.||||.    ||  || ..||. ||| .  |. |...| | ...||| .|...|..||
kfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWp

DHGVPDDSSDFLDFVCHVRNKRagKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYE
|||||.. ...|||. .||...  ...|.|||||||.||||..|.........|... | ....|...| ||..|.|||.||.|...|.|. ..
dhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
subfamily_PTPN3_pd Subfamily PTPN3 639-917 6.8e-154 505.7 In-house 1-280 (280) alignment 
Range on Protein: 639-917
Range on HMM: 1-280/280.0
LRESMIQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNE-DYINANYINMEIPSSSIINQYIACQGPLPHTCTDF
||||...|.||| .|.||.||.||||||||...|.|..|.|.||||||||.|||||||.|| .| |||||||.||||||....|.|||.||||..|.|||
lresllllkeglesGavlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklkesetdyinanyvnmeipstglvnryiatqGPlaktatdf

WQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHV
|||.||| ||..|||||.||||||||||||||.. ...||...|.|..|. ...|..|...| ..|..|.|...|.||.|||||||||||.|||.||..|
WqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefverv

RNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFV
|..|.|||||||||||||||||||||..|||..|||...|||||||||||||||||..||.|||.||||||||||||..|
rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyeeilv
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 639-913 4.1e-71 234.6 In-house 10-284 (319) alignment 
Range on Protein: 639-913
Range on HMM: 10-284/319.0
LRESMIQLAEgliTG--TVLTQFDQLYRKKPGmTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINME-IPSSSIINQYIACQGPLPHTCT
|.| . .||.   ||  ..  .| .|   ..  |.. |. ..| .||||..| .|| |||.|.  ..  ...||| . | .    ...|| |.|| .|  
Lkerlkalas...tgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentie

DFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTgSSSYGCYQVTCHSEEGNTAYIFRKMTLfNQEKNES--RPLTQIQYIAWPDHGVPDDSSDFLDF
|||.| ||..||.|||||  ||...||...|||| .   .|| . ||  .||    || ||..| |. ..|   | ... || .||||.||...   ||.
dfWrmvWeeessivvmltklveklkvklkkywpeen.feeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPekatslldl

VCHVRNKRAG-KEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYE
. ..|. | . .. |.|||||||.||||  |... ..  .. .. .    .|...| || .|.|.|.||.|. ||.|.. |
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleave
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 643-909 4.2e-25 82.8 In-house 16-282 (302) alignment 
Range on Protein: 643-909
Range on HMM: 16-282/302.0
MIQLAEGLITGTVLTQFDQLYRKKPGMTMsCAKLPQNISKNRYRDISPYDATRVILK-GNEDYINANYINmeIPSSSiiNQYIACQGP---LPHTCTDFW
 ..| . | |..| ..|...   |  . . |    .|..||.  |.  .|...|.|.  ...|.||  ..  .|. .  .. |  | |    ..   .||
akklvksldtaevkkefkkidtmkvdlek.Ckafkknlkknqsedvpildsnlvkleaepdsyvnaskve..vPelt..rsiilaQlpkvdsedsveeFW

QMTWEQGSSMVVMLTTQVERGRvKCHQYWPEPTGS-SSYGCYQVTCHSEEGNTAYI-FRKMTLFNQEKNESrPLTQIQYI-AWPDHGVPDDSSDFLDFVC
.| ...   .||.|  . |  .   ....|. .|. . ||   |     |   .      . .. ..  .| .|.... .  |... ||.  ..    . 
rmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsns.vlanvyvltnWkqkkvpvkyaeliktaa

HVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAIL
.| .| .  .|..|.    |.|| |...|. .|.. .. .. .   .||...| ||. .... .|| ..  |.|
kvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyiall
subfamily_PTPN14_pd Subfamily PTPN14 644-911 3.1e-73 241.4 In-house 14-295 (300) alignment 
Range on Protein: 644-911
Range on HMM: 14-295/300.0
IQLAEGLITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKG----NEDYINANYINMEIpsSSIINQYIACQGPLPHTCTDFWQ
 .| . |  | | |..... .|.   ..|.||||.| .|||..|. ||. .|| |.     ...||||  |.. .  ..   .||..||||..|..||||
kilekkleegkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsv..ggkersyivaqgPleltvqdfWq

MTWEQGSSMVVMLTTQVERGRVKCHQYWPEP---TGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCH
| |||| ...|||| . | |. |...|.|.      .  .| ..|| .  |  ...| ....|     .| | .  .||. |||||||.| ..||... .
mvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLee

V---RNKRAGKE------EPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV
|   |.|   .        ||.||||||.|||||||. .  .  .|.|. .    .....| || ...|| .||.|| ....| 
vqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 645-906 9.3e-37 121.2 In-house 19-284 (310) alignment 
Range on Protein: 645-906
Range on HMM: 19-284/310.0
QLAEGLITGTVLTQFDQLYRKK-PGMTMscAKLPQNISKNRYRDISPYDATRVILKG----NEDYINANYINMEIpsssIINQYIACQGPLPHTCTDFWQ
  .| |    .  |. .|  |. . .|.      ... |||| |.   |..|| ||      |||| |||.. .     . . .| .|||| ||  |||.
iateklgieglvkqyrkldakqdsslty..eaykkymhknrysdvvcldtsrvklkidksryedyihanyvktny....lrstficsqgplqhtiidfwr

MTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKM--------TLFNQEKN-ESRPLTQIQYIAWPDHGVPDDSSDF
| ... .  ...|   .| || ||  |||    . .||| .||  ||  .   |             . .|  | .   .. |..  ||| ||||.    
mifqeraesilllckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekcht

LDfvchVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCE
.      |     .  |.|||||||..|..|..... ..  ..  . |   ...  .. .||. |||. || ..  
vp....qrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidr
0036941 (Phosphotyrosine protein) phosphatases II 650-918 8.3e-93 306.2 In-house 10-283 (297) alignment 
Range on Protein: 650-918
Range on HMM: 10-283/297.0
LITGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNE-DYINANYInmeiPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSM
| .  .|..|..|.. .. ...|.|.||.|..||||.|| ||| |||.|.... |||||.|.    .  .. ...||.|||||.|. |||.| |||....
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyv....dgydlkrkfIatqgPlpntvedFWrmvweqnvtv

VVMLTTQVERGRVKCHQYWPEP-TGSSSYGCYQVTCHSEEG--NTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRA--G
.||||. ||.||.||.||||.   .|  || ..||. |.|   .. |. |.... . ...||| .|...|. |||||||.. ...|||.  ||....   
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllp

KEEPVVVHCSAGIGRTGVLITMETAMCLIE---CNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFVK
...||.||||||.||.|..|.........|    .. | .|..|...|.||....||..||||..||.|. .  . .|
sggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
0047943 (Phosphotyrosine protein) phosphatases II 652-910 1.2e-89 295.7 In-house 11-270 (273) alignment 
Range on Protein: 652-910
Range on HMM: 11-270/273.0
TGTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVIL-KGNEDYINANYInmeiPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVV
....| .|..|.. || .|.|.|.||.|..||||.|| ||| .||.|  |. |||||.|.    .   . ...||.|||||.|. |||.| |||.....|
ltllleefelllslkplltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyv....dgynlkrkfiatqgPlpntvedfwrmvweqnvrviV

MLTTQVERGRVKCHQYWPEPTG--SSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAG--KEE
|||. ||.||.||.||||.  |  |  || ..||. ||| .  |. |...| | . .|||  |...|  |||||||.. ...|.|. .||....   ...
mLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsng

PVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
|||||||||.||||..|.........|... | .|..|. .|.|| .|.|||.||||..||.|.
pvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0051299 (Phosphotyrosine protein) phosphatases II 653-911 2.6e-95 314.4 In-house 23-285 (288) alignment 
Range on Protein: 653-911
Range on HMM: 23-285/288.0
GTVLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILK-----GNEDYINANYInmeiPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSS
 ..| .|..|....| .|.|.|.||.|..||||.|| ||| .||.|.     .. |||||.||    .   . ...||.|||||.|. |||.| |||...
tglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi....dgynlkrkfIatqgPlpntvedFWrmvweqnvr

MVVMLTTQVERGRVKCHQYWPEpTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQ----EKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAG
..||||. ||.||.||.||||.  ||  || ..||. ||| .  |. |.... |      ..|||  |...|..||||||||. ...|||. .||...| 
vIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalas

KEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV
.. |||||||||.||||..|.........|... | .|..|...| || .|.|||.|||||.||.|  
gggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0043336 (Phosphotyrosine protein) phosphatases II 653-910 1.3e-88 292.4 In-house 20-275 (278) alignment 
Range on Protein: 653-910
Range on HMM: 20-275/278.0
GTVLTQFDQLYRKKPgMTMSCAKLPQNISKNRYRDISPYDATRVILKG-----NEDYINANYInmeiPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSS
 ..| .| .|.. |. .|.|.|.||.|..||||.|| ||| .||.|.      . |||||.|.    .  .. ...||.|||||.|. |||.| ||.|..
tllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv....dgynvprkfiatqgPlpetvedFwrmvwelgvt

MVVMLTTQVERGRVKCHQYWPepTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEP
..||||. ||.|||||.||||   ||  || ..||. .|| .  |. |.... |  ..|||  |...|..|||||||.. |..|||.  ||.... ...|
tivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavrealedsngp

VVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
|.||||||.||||..|.........| .. | ....|...| ||....||||||||..||.| 
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0039614 (Phosphotyrosine protein) phosphatases II 653-912 8.3e-87 286.7 In-house 32-289 (297) alignment 
Range on Protein: 653-912
Range on HMM: 32-289/297.0
GTVLTQFDQLYRKKPGmtMSCAKLPQNISKNRYRDISPYDATRVILKGNED------YINANYInmeiPSSSI-INQYIACQGPLPHTCTDFWQMTWEQG
...|..| .|.. ||   .|.|.||.|..||||.|| ||| .||.||....      ||||.|.    .  ..  ...||.|||||.|. |||.| ||||
tllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv....dgydlltrkfIatqgPlpetvedFwrmvweqg

SSMVVMLTTQVERGRvKCHQYWPEPTGssSYGCYQVTCHSEEGNTAYIFRKMTLFNqeKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAG--
....||||. ||.|| ||.||||| .|   || ..||. ..| .  |. |.... |  ..||| .|..||. |||||||......|.|.  ||. .|   
vtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvrealaelp

KEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY
|..||.||||||.||||..|.. ......|... | .|..|...| || ...||||||||...|.|. .
kggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 653-913 5e-59 194.4 In-house 10-278 (287) alignment 
Range on Protein: 653-913
Range on HMM: 10-278/287.0
GTVLTQFDQLYRKKPGMTM--SCAKLPQNISKNRYRDISPYDATRVILKGN----EDYINANYInmeiPSSSIINQYIACQGPLPHTCTDFWQMTWEQGS
  |  ..|.| .   ..|.    |.   ...|||| |. |.| |||.|  .     |||||||.    .|    ...||.|||.. |  |||.. .|. |
ddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyv....asytddeafiaaqgPiaatvrdfwravletrs

SMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEG-NTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHV----RNKR
. |...| .|| .| ||..||||.      | | |.  . .  .  |  | . | . | .|.| . |.....|||....  .  .. ||  |      .|
asvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielar

AGKE-EPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYE
 ..|  |.|||...||||.|.|... . .   |    | .  .|  .| .|| ..|.. |.|...||.   |.
dasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
0040438 (Phosphotyrosine protein) phosphatases II 654-917 2.4e-91 301.6 In-house 19-281 (317) alignment 
Range on Protein: 654-917
Range on HMM: 19-281/317.0
TVLTQFDQLYRKKPGmTMSCAKLPQNISKNRYRDISPYDATRVILKG-----NEDYINANYInmeiPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSM
 .| .| .|.. |.  |.|.|.||.|..||||.|| |||..||.|.      . |||||.|.    .  .. ...||.|||||.|. |||.| ||||...
alleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv....dgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

VVMLTTQVERGRVKCHQYWPEpTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPV
.||||. .|.||.||.||||.  ..  || ..||. ||| .  .. |.... . ...||| .|...|..|||||||.. ...|||.  ||........||
ivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpv

VVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGFV
.||||||.||||..|.........| .. | . ..|...| ||....|||.||||...|.|. .  . .
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
0045450 (Phosphotyrosine protein) phosphatases II 654-912 7e-88 290.6 In-house 28-304 (307) alignment 
Range on Protein: 654-912
Range on HMM: 28-304/307.0
TVLTQFDQLYRKKP--GMTMSCAKLPQNISKNRYRDISPYDATRVILK------GNEDYINANYINMEI----PSSSIINQYIACQGPLPHTCTDFWQMT
 .| .| .|.. ..   ...|.|.||.|..||||.|| ||| |||.|.      .. |||||.|... .    ..  . ...||.|||||.|. |||.| 
gllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetvedFwrml

WEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQ-EKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNK
||||....||||. ||.||.||.||||.  ..  || ..||. |||    |. |.... .  ...||| .|...|..|||||||.. ...|||.  ||. 
weqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrka

RAG--KEEPVVVHCSAGIGRTGVLITMETAMCLIECNQP---VYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY
..   |..||.||||||.||||..|.. ......| ..    | .|..|...|.||  ..|.|.||||..||.|. .
leelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0045098 (Phosphotyrosine protein) phosphatases II 655-913 7.1e-83 273.4 In-house 9-273 (278) alignment 
Range on Protein: 655-913
Range on HMM: 9-273/278.0
VLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVIlkgneDYINANYINMEiPsssiiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTT
.|..|..|..  .  ....| .. |..||||.|| ||| .||.     |||||.||..  |     ...||.|||||.|. |||.| ||.|.. .||||.
lllefefllllgipseitpalylgnldknRykdilpydhsrVk.....dYINAsyidgy.p.....kkfIatqgPlpstvadfwrmlwelgitvivmlte

QVERGRVKCHQYWPEpTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQ----EKNESRPLTQIQYIAWPDHGVPDDS--SDFLDFVCHVRNKRA------
 ||.||.||.|||||  ||  || ..||. ||| .  |. |.... |     | .||| .|...|. |||||||...  . ||...  .|. ..      
lvelgrekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasll

-------GKEEPVVVHCSAGIGRTGVLITMETAMCLIecNQPVYPLDIVRTMRDQRAM-MIQTPSQYRFVCEAILKVYE
       ....||.||||||.||||.|. . . ..|.  .. | .|..|...| || . ..|...||||..|..|....
lsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 655-911 1.2e-77 256.1 In-house 22-279 (318) alignment 
Range on Protein: 655-911
Range on HMM: 22-279/318.0
VLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNE-----DYINANYInmeiPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMV
. .....| |..  .|   .  | |  |||| .| .|| ||| |.  |     ||||||||    .     ..|||.|.|||.|..|||.| |||.|...
lseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyi....dGyrrkkayiaaqaPlpetieDfWrmvWeqnsavi

VMLTTQVERGRVKCHQYWPEpTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKR-AGKEEPV
|||| ..|||..|.|.|||.  || |||  .|. ..|   . |. |.... ..|..|||   | .| .|||.|||......||.| .|..     ...|.
vmltqeeergkakvhryWPs.kgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpi

VVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV
|||||||.||||| |.... .  |. .. |  ...|...|.|| .|.|| .|| |. ...|. 
vvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllea
subfamily_PTPN9_pd Subfamily PTPN9 655-910 4.7e-68 224.4 In-house 18-288 (297) alignment 
Range on Protein: 655-910
Range on HMM: 18-288/297.0
VLTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNE-----DYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMV
.  .. .. ....  |. ..||. |..|||| |.  || ||| |.  .     ||||||...         . .|| ||||..|..|||.| |||   ..
lskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvd....GykqkkafiatqGplkktvsdfWrmvWeqevlvi

VMLTTQVERGRVKCHQYWP-EPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAG-----
|| |  |||||.|| |||| |   |...| ..|.  . | . .| .|.... | ...||| .|  |...|||.|||......||.. .||.|.|      
vmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkel

--------KEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
        .. |.|||||||||||| .||.. ..  .|  . |   . |...| ||| .|||| || |   |.| 
gdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_PTPN13_pd Subfamily PTPN13 656-912 1.2e-82 272.3 In-house 14-269 (273) alignment 
Range on Protein: 656-912
Range on HMM: 14-269/273.0
LTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIpsSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQ
  .|..|   ||  | . .|  .| .|||||.. |||.|||.|...  ||||..|....       .|||||||||.|..||||| ||| .....|.|..
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdeggyinaslikvpv..gkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtle

VERGRVKCHQYWPEPTGSSS--YGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAgKEEPVVVHCS
.|.|.||||.|||| ....   .. ..|.    .   ..  |.... ..| .||| ........|||||||  . ..| ||..||. .  .. |.|||||
kekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcs

AGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY
|||||.|.|||..... ||| ....   .|||..|.||  ..||  || || .|||.| 
aGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 656-912 1.5e-81 268.6 In-house 18-276 (281) alignment 
Range on Protein: 656-912
Range on HMM: 18-276/281.0
LTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINME-IPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTT
 .....|.    . | . .| ..|. ||||..|. |||||| .. ||.  |..||| . .|. .  ..|||.|||.|.....|||| |||  |..||.| 
ieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtr

QVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLfNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHV-RNKRAGKEEPVVVHCS
..| |..|||.|||... . .|| ..|. ..|| .. || ||..| ..|..|.| ..|..|.||||||||......|.|   | . ..  .. |.|.|||
eieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktkaplvihCs

AGIGRTGVLITMETAMCLIECN-QPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY
||.||||. |......  .| . ... . ..|. .| .| .|.||  ||.||  |.|.. 
aGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_PTPN6_pd Subfamily PTPN6 656-912 5.3e-78 257.1 In-house 29-297 (306) alignment 
Range on Protein: 656-912
Range on HMM: 29-297/306.0
LTQFDQLYRKKPG--MTMSCAKLPQNISKNRYRDISPYDATRVILK----GNEDYINANYINMEIPSSSiiNQYIACQGPLPHTCTDFWQMTWEQGSSMV
  .|..| ...    .. . .. |.| .||||. | |.| ||||||     ..||||||||. |...|.  ..||| || |..| .|||.| |.. | ..
eeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsd..ksyiatqgclettvsdFWrmvwqensrvi

VMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLF-NQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKE---
||.|..||||. || .|||. . ...|| ..||. ||. ...||.|....  ...|.|.| . | .. .||||||| | . .|||. .|..|.   |   
vmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeae

-EPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDI---VRTMRDQRAMMIQTPSQYRFVCEAILKVY
  |.|||||||||||| .| ... . ||| .   ...||   |...|.||  ..|| .||.|| .|| |  
agpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_Ptp69D_pd Subfamily Ptp69D 656-913 1.4e-60 200.0 In-house 25-287 (307) alignment 
Range on Protein: 656-913
Range on HMM: 25-287/307.0
LTQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGN-----EDYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVV
.  ...| ...   . . ..   |  |||| || ..| |||.||        |||||..|.    .    ...|| |.|.  |  |||.| .|| . ..|
akeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik....gykekkkfiaaqdPveatigDfWRmiaeqevtliv

MLTTQVERGRVKCHQYWPEPtGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQE-----KNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKE
||.   |  | ||..|||.      ||   |.. |||  . || |.. . ...      ..|| ..| .| .|.|  ||. .   |... .||.    ..
mlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnr

EPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYE
 |.||||||| ||.|......  .  .. .. |   ..|. .| || ...|   || |.  |.|.  .
sPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
0046845 (Phosphotyrosine protein) phosphatases II 657-913 1.6e-92 305.2 In-house 4-275 (284) alignment 
Range on Protein: 657-913
Range on HMM: 4-275/284.0
TQFDQLYRKKPGM--TMSCAKLPQNISKNRYRDISPYDATRVILK------GNEDYINANYINME-IPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSS
 .| .|.. .. .  ..|.|.||.|.|||||.|| ||| .||.||      .. |||||.|...  .. . | ...||.|||||.|. |||.| |||...
eefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqnvr

MVVMLTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQE-KNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRA--GK
..||||. ||.||.||.||||.  ..  || ..||. ||| .  |. |...| | . ..||| .|...|..|||||||....|.|.|.  ||. .   ..
vIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpg

EEPVVVHCSAGIGRTGVLITMETAMCLIECNQ---PVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYE
..|.|||||||.||||..|.........| ..    | .|..|. .|.|| .|.||..|||||.||.|  . 
ggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
DSPc_SM00195 657-912 3e-85 281.1 In-house 4-262 (263) alignment 
Range on Protein: 657-912
Range on HMM: 4-262/263.0
TQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGN-----EDYINANYINMEipssSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVM
..|..| ....  ....|. ..| |||||..| ||| |||.|| .     .||||||||...    .  ..|||.|||||.|. |||.| ||......||
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivm

LTTQVERGRVKCHQYWPEP-TGSSSYGCYQVTCHSEEGNT-AYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVV
|| ..|.|. ||..||||   |.. .| ..|.. ..|     .| |...| ...|.|.| .||.|| .||||||||. ...|...  |....  ...|.|
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY
||||||.||||...|.....  .| .. |   .||. .|.||..|.||  ||.|..||||...
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 657-912 3e-85 281.1 In-house 4-262 (263) alignment 
Range on Protein: 657-912
Range on HMM: 4-262/263.0
TQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGN-----EDYINANYINMEipssSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVM
..|..| ....  ....|. ..| |||||..| ||| |||.|| .     .||||||||...    .  ..|||.|||||.|. |||.| ||......||
eefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga....nkkkkyIatQgPlpstvedFWrmvweekvkiivm

LTTQVERGRVKCHQYWPEP-TGSSSYGCYQVTCHSEEGNT-AYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVV
|| ..|.|. ||..||||   |.. .| ..|.. ..|     .| |...| ...|.|.| .||.|| .||||||||. ...|...  |....  ...|.|
lteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpiv

VHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY
||||||.||||...|.....  .| .. |   .||. .|.||..|.||  ||.|..||||...
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPRB_pd Subfamily PTPRB 657-914 6.5e-82 269.9 In-house 29-287 (293) alignment 
Range on Protein: 657-914
Range on HMM: 29-287/293.0
TQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVIL-----KGNEDYINANYInmeiPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVM
 ....|   .  .....|.|..| .||||..| |||..|| |     . ..||||||||    |  .  ...||.|||||.|  |||.|.||. ||..||
eeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyi....pgynsprefiatqGPlpetvddfWrmvwekkssiivm

LTTQVERGRVKCHQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNqeKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKR--AGKEEPVV
||  ||.|.|||..|||. . .  ||  .||  .||  . .. |.... .  ..|.| ..| ....|||||||.... .|||| .||..   . ...|.|
ltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiektaskrPiv

VHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEE
||||||.||||..|.... .  || .. |  . ||  .| .|....|| .|| |. ...|.. ..
vhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_PTPN12_pd Subfamily PTPN12 657-914 2.9e-74 244.6 In-house 18-279 (290) alignment 
Range on Protein: 657-914
Range on HMM: 18-279/290.0
TQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKG-----NEDYINANYINMeiPSSSiiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVM
 .  . |...  .. .... ..|. ||||.|| ||| .|| |.      ..||||||.|.   ....   .||| |||||.| .|||.| ||.  ..|||
kklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikg..vegk..leyiaaqgPLpktlddfWrmiweknveivvm

LTTQVERGRVKCHQYWPEPTGSSS-YGCYQVTCHSEEGNT-AYIFRKMTLFNQekNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVV
.  .|| |. ||..|||| ....  .| ..||...|.  .  .. | ... .|  .||| ..|..| ||||||||   .. |... .||. .  ...|.|
aCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlv

VHCSAGIGRTGVLITMETAMCLIECNQP---VYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEE
||||||.||||..|... .  |.. ..    .   |.|...| ||| ..||  ||..| .|.... ..
vhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 657-910 1e-62 207.0 In-house 26-281 (305) alignment 
Range on Protein: 657-910
Range on HMM: 26-281/305.0
TQFDQLYRKkpGMTMSCAKLPQNISKNRYRDISPYDATRVILKGNE-----DYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVM
.|...||..  . ..   |  .| .|||...| ..|  |.||. .|     |||||.|..    . .  ..||. ||||..| .|||.. .|   | .||
aqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvd....gykrkkkyivaqgPlkntvadfWrliveekvstivm

LTTQVERGRVKCHQYWPEPTGS-SSYGCYQVTCHSEEGNTAYIFRKMTLFN-QEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRA-GKEEPV
||  || |. ||.||||| ..    .| ..|. .||.  . || ||... . .|..||| ..| |   |||||||. .. .|... .|....  .|. |.
ltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdkgvpl

VVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
.||||||.||||| |... |.  ..  . |   ......| .|  |.||  || |. .|. .
lVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdalde
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 657-913 1.6e-58 192.9 In-house 24-284 (290) alignment 
Range on Protein: 657-913
Range on HMM: 24-284/290.0
TQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILK---GNED----YINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMV
.|| .|   .   |.  .  ..|  .||...| .||  |..|.   |..|    |||| ||.      .  .|||| |||...|  |||.. |.. ....
nqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik....gykekkqyiatqgpvsntlvdFWkliwqekvtii

VMLTTQVERGRVKCHQYWPEPtGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEK-NESRPLTQIQYIAWPDHG-VPDDSSDFLDFVCHVRNKRAGKEEP
||||. .| |.|||.||||.  ....|| .... ..||  . || ||. . |... .... .|| |  .|...| |.. ..  | .   ....|   ...
vmltniieegkvkCqqYWpds.dtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrgnts

VVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYE
.|||||...||..|.....|..   . .. .  .......| |.  ..||  ||..... .|.  .
ivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 657-914 2.6e-40 133.3 In-house 20-279 (307) alignment 
Range on Protein: 657-914
Range on HMM: 20-279/307.0
TQFDQLYRKKPGmTMSCAKLPQNISKNRYRDISPYDATRVILKGN---EDYINANYINMEIPSssiiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLT
 .| .| .|.|  ...   .  |  ||||.|.   | .|...| .    ||| |||. . |      ...|..||||  |  .|| |. ..    |.|| 
defrvlakktpe.gvtveafsantdknryqdvkcqdkgrivvkfdglasdyihanylgiaikp....kkficaqgplentqysfwamaiqekvesvimlc

TQVERGRVKCHQYWPEPTGSS-SYGCYQVTCHSEEGNTA------YIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRnkraGKEE
  .| ...||.||||   |    .|    |   ..  .        .    ||  .  ..|| ....|.  |||.|||.     ....  ||    ....
kvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavr....ydtn

PVVVHCSAGIGRTGVLITMETAMC-LIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEE
|||||||||.||.| ....   .  .|.        ..|. .|.||   |||  || ..   .|. . |
pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyfle
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 657-910 2e-39 130.1 In-house 19-291 (301) alignment 
Range on Protein: 657-910
Range on HMM: 19-291/301.0
TQFDQLYRKKPGMTmSCAKLPQNISKNRYRDISPYDATRVILKGNED-------YINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMV
 |...|.....  . .     .|   ||...|..||  |.||| ...       ||||.||.    . |  ...|| |||. .| .|||.. |..  . .
eqykelkegedksc.tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyid....gysekkkfiaaqgpmkktlvdfWrliwqekpvsi

VMLTTQVERGRVKCHQYWPEPTG-SSSYGCYQVTCHSEEGNTAYIFRKMTLF--------------N-QEKNESRPLTQIQYIAWPDHGVPDDSSD---F
||.| . |. . ||.||||. .  |...|  .|| ..|     .. |....               . .....|. ..|.| . ||..||  .       
vmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqv

LDFVCHVRNKRAGkeEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
.| | | ..|  |   |||||||....|.|| .... ..     .  |   ......| ..  ...|  || .. ..| .
iddvihrqqkigg..gpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 657-744 2.2e-08 28.0 In-house 15-108 (347) alignment 
Range on Protein: 657-744
Range on HMM: 15-108/347.0
TQFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGN----------EDYINANYINMEipssSIINQYIACQGPLPHTCTDFWQMTWEQ
| ||.   .     .. ..  ...|||| .|    |||||.|  .          | |||| .|...       ..||  | |||.|  |||.|    
tyfdenlanyspskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfd....naskeyiltqyplpdtvrdfwkmvsvt
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 658-912 1.8e-56 186.2 In-house 28-278 (287) alignment 
Range on Protein: 658-912
Range on HMM: 28-278/287.0
QFDQLYRKKPGMTMSCAklPQNISKNRYRDISPYDATRVILKGN-EDYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQV
 ..|. ...  .|.. |  .||  |||...| ..|  ||.|||. .||||| .|.    . .  ...|....|. .|  .||.. ...  . .|||. . 
vleqvtqredevthnia..sqnkdknRltqilvpdnyrvllkgehpdyinavfid....gykekkafiiaesPmfntarnfWkliddrnvtaivmlcqek

ERGRVKCHQYWPEPTGsSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNE-SRPLTQIQYIAWPDHG-VPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSA
|  . .|.||||| .   ..| |...  .|| |. || ||. . |..|..  . ..| |. .|...| |..  . .| .   ....|   . ..|||||.
endeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsivvhCsd

GIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY
..||..... ..|..   . .  .  ..... .| |.  ..|| .||.|.....|.  
tvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 658-835 8.7e-40 131.4 In-house 12-194 (297) alignment 
Range on Protein: 658-835
Range on HMM: 12-194/297.0
QFDQLYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKG---NEDYINANYINMeiPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTT
. | |.... | ..| || .  . |||||||  .| ||| |..   ..|||||.|. .  |      .||  ||||  |  |||.. .||.  ..||.. 
ekdllldeargesfssakrnsslrknryrdilatddtrvkllrviterdyinadyvvf..pdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvak

QVERGRVKCHQYWPEPTGSSS----YGCYQVTCHSEEGNTAYIfRKMTLFNQekNESRPLTQIQYIAWPDHGVPDDSSDFLDF---VC
  | || ||  |||.  .       .    ..  |.| .. ..  ...|. .  .||| .. .|...||||||| |  |   |   ||
lqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrvil.telqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvc
subfamily_PTPRD_pd Subfamily PTPRD 659-911 3.7e-87 288.3 In-house 29-280 (564) alignment 
Range on Protein: 659-911
Range on HMM: 29-280/564.0
FDQLYRKkPGMTMSCAKLPQNISKNRYRDISPYDATRVILK-----GNEDYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLT
. .. .. . .|.. |. |.| .|||| .| .||..||.|.      . |||||..|.    .    ..||| ||||..|. |||.| ||| ||..||||
ykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfid....gyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmlt

TQVERGRVKCHQYWPEPTgSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCS
  .|.|.||||.|||| . . .|| ..|| ..||  . |..|...| .....|||  .| ....|||||||.   ..||.. .||. .  ...|.|||||
kleEkgkvkchkYWPekg.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagPivVhCS

AGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV
||.||||. |...  .  |. .. |    .|...| || .|.||..|| |. ||||. 
aGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailea
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 659-912 1.6e-54 180.0 In-house 26-279 (315) alignment 
Range on Protein: 659-912
Range on HMM: 26-279/315.0
FDQLYRKKPGMT---MSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINME-IPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTT
| | |   ||     .  ||  .|  |||| .| .|| .|| |   |   ...|.| . |.  .  ..|||.|||.. .  |||.. .|.  . .|||| 
fkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltn

QVERGRVKCHQYWPEPtgSSSYGCYQVTCHSEEGNTAYIFRKMTLFnqEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSA
 ||. . |. .|||.      || . ||  ||| || |  | ..     ... | . |..| .||| |||  .  ..... .|.  .  .  ..||||||
lvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtlsvv..fgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsa

GIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY
|.|||| .||... .  .| .. .   .... .|..|  |.|.  ||.|. .|.|. .
GvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 659-909 3.6e-32 106.1 In-house 13-266 (281) alignment 
Range on Protein: 659-909
Range on HMM: 13-266/281.0
FDQLYRK----KPGMTMSCAKLPQNISKNRYRDISPYDATRVILKG------NEDYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSM
| | . .     |    .. . | |  |||| .|   | .|| ||         ||| ||||     |  .   ||  |||   | .|||.| |.. .. 
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyir....spflkrgyiltqgpkketradfwrmiwqentta

VVMLTTQVERGRVKCHQYWPEPTGS-SSYGCYQVTCHSEEGNTAYIFRKMTLfnQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNkragKEEP
.|||   .|  | || .|.|  .     .  . |.      | . .  .. |    . |.| .|.  .  |||  ||. |  .|  . ..|     .  |
ivmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnl..syegetrlithwlwkewpdwqvpessevmlkilrkira....rstp

VVVHCSAGIGRTGVLITMETAMCLIECNQPVYPL-DIVRTMR-DQRAMMIQTPSQYRFVCEAIL
 |.|||||.||.| |...| |.  | .   .  . .||  .|   ||  .||  || .. . .|
pvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvll
subfamily_eak_pd Subfamily eak 661-834 4.2e-16 53.3 In-house 34-204 (332) alignment 
Range on Protein: 661-834
Range on HMM: 34-204/332.0
QLYRKKPGMTMSCAKLPQNISKNrYRDISPYDATRVILKGNEDyINANYINMEIPS-SSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERG
.| .... ...| ..  ... .|   .| |||   | |       .  |||  .   | . ..||    .       ||||  || |  .|.|  .|| .
dlddyqrllsisetarleavnrn.vvkivpydrylvrltssql.nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelk

RVKCHQYWPEPT-GSSSYGCYQVTCHSEEGNTAYIFRKMTLfnQEKNESRPLTQIQYIAWPDHGVPDdSSDFLDFV
  |  .|.|. |    ..| ..|.. .   .  . .|.. |  .  ||.  .   ..  | .  .|    ||| . 
leksdkyfpdktreelkfGildverkefvkrniletrllel..skGnethrvlhykvfGwtettlpk.yedflalr
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 662-915 1.7e-49 163.7 In-house 31-291 (325) alignment 
Range on Protein: 662-915
Range on HMM: 31-291/325.0
LYRKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILK-----GNEDYINANYINMEIPSssiiNQYIACQGPLPHTCTDFWQMT--WEqgsSMVVMLTT
|   . |...  | .|.|..|||.... ..| .||.|.     .. |||||.|.. ..      . ..|.| ||..|  |.|..   |.   . ||... 
llpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkk....dvflaaqaPltatindlWrlvldWr...csvvvvln

QVERGRVKCHQYWPEPTG-SSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSS---DFLDFVCHVRNKRAG---KEEP
... |  .| .|||.  | |  .|  .|   . |  . |. |.. . . .| |.| . | |. .|.| ||.   .    .|. | .| ..         |
eldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastp

VVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEG
..||||||.|||||.|.. .|.  .  .  |  .. |. .| .|  |..|  || .. ||. ..|  |
ilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsg
subfamily_PTPRN_pd Subfamily PTPRN 664-909 8.8e-57 187.1 In-house 42-289 (297) alignment 
Range on Protein: 664-909
Range on HMM: 42-289/297.0
RKKPgMTMSCAKLPQNISKNRYRDISPYDATRVILKGN-----EDYINANYINMEIPSSsiiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVER
. .|  | . || ..|..|||.... ||| .|| || .     .|||||  |  . | .     |||.||||..| .||||| ||||. ..|.||.  | 
eaep.stkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdpra...payiatqgplastvadfwqmvweqGvvvivnltrleee

GRVKCHQYWPEpTGSSSYGCYQVTCHSEEG-NTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIG
|  .|..|||. .||. |. |.|   ||      |. | . | | ...|.| .||  ...||..|||  .  .|.|   |     |.  |.|||||.| |
gvkqckrywpd.eGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaG

RTGVLITMEtaMCLIECNQPVYPLDIVRT---MRDQRAMMIQTPSQYRFVCEAIL
|||| | ..  . |   .. |  .||. |   .||||. ...| .|..|.  |. 
rtGvyilid..lvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 664-913 3.1e-37 123.0 In-house 33-288 (305) alignment 
Range on Protein: 664-913
Range on HMM: 33-288/305.0
RKKPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGN--EDYINANYINmeIPSSSiiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRV
| .    | . |  |.  ||||.|.   |  || |.|    .|| |||.    |. .  ...| .| || .||.||| | ...   .. ||   .|.|  
rfndfekmkafkeaqeagknrykdvgcldnnrvklegpwpheyihanyvs..tptnp..krfictqaplektcadfwymclqdkveaifmlcnllekgak

KCHQYWPEPTGS---SSYGCYQVTCHSEEGnTAYIFRKM---------TLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRagkeEPVV
||..|..   .     . .  ... . |   ... |||           . .   ...|  |.  .| ||| |||      |... . |  .     |.|
kcleyfaskdkdvlefeekgqkisvkfess.vtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailellekarpsk....gpiv

VHCSAGIGRTGVLITMETAMCLI-ECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYE
||||||||||| .. .|  .  . . ..      |.. .|.||   |||  || || . ||. ..
vhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_PTPRG_pd Subfamily PTPRG 665-911 6.7e-60 197.9 In-house 33-286 (563) alignment 
Range on Protein: 665-911
Range on HMM: 33-286/563.0
KKPGMTMSCAKLPQNISKNRYRDISPYDATRVILK------GNEDYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVER
..  .... .. |.|  |||| .| .|| .|| |.      .. ||||||||.         ...|| ||||..|. |||.| ||| ....||.|  |||
iskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyid....GyqkskafiatqgplkdtfddFWrmiWeqnvaiivmitnlver

GRVKCHQYWPEpTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFN------QEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHC
|| ||..|||.  .|  ||  |||  .||  . |  |.... |      ..... .  .| .|  |||||||. |   | || .    .  .  |.||||
grrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankaeaGPivvHc

SAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV
|||.||||..| ..| .  |. .. |  .......| || ...||  || |. .|.|..
saGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdallea
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 665-910 2e-57 189.9 In-house 47-289 (319) alignment 
Range on Protein: 665-910
Range on HMM: 47-289/319.0
KKPGMTMSCAKLPQNISKNRYRDISPYDATRVILK---GNE--DYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTtqverg
  .. ... | |.||  |||. .| ..| ..| |.   | |  ||||| ...         ..|||.||||. |  |||.| ||. .| .|.||      
gvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvt....GyqrkdkyiaaqGPldntladfWrmiweyncstivllt......

RVKCHQYWPEpTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFN-QEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRN--KRAGKEEPVVVHCSAGI
. || ||||   .   .. ..|  .| |    |. |.. | .  .... | .||  .  |||.|||| .||.. .| .||   ..  .....|||||||.
kdkcsqywpl.kivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGv

GRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
||||| |.... .  .. .. |   ..|| .|.||  ..|   || |.  |.|.
GrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 666-912 3.8e-68 224.9 In-house 43-290 (298) alignment 
Range on Protein: 666-912
Range on HMM: 43-290/298.0
KPGMTMSCAKLPQNISKNRYRDISPYDATRVILKG-----NEDYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGR
 .  ... |. |.| .|||| || ..| .||.|.      . ||||| ...    . .  | .||.|.||..| .|||.| .|. .. .||||. .| ..
ieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh....aykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldk

VKCHQYWPEpTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNK-RAGKEEPVVVHCSAGIGRT
.|.|.|||. .|.  ||  .|. .|.|  . .| ||... .......| . |.... |||.|||  ..  ||.. .|| . .  ...||.|.||||.||.
tkyhkywPd.egketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagnkpvivqCsaGvgRs

GVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVY
|  | ... .  .. .| |  ...|...| .|. ..|| .|| |. ||.|.. 
GtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 666-911 9.6e-57 187.6 In-house 12-254 (284) alignment 
Range on Protein: 666-911
Range on HMM: 12-254/284.0
KPGMTMSCAKLPQNISKNRYRDISPYDATRVILK---GNE--DYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTtqvergR
 .| ... | |.||  |||. .| ..| ..| |.   |.|  ||||| .|.         ..|||.||||. |  |||.| ||. .| .|.||      .
vngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfit....GyqrkdkyiatqGPldntladfWrmiweyncstivllt......k

VKCHQYWPEpTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFN-QEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRN--KRAGKEEPVVVHCSAGIG
 || ||||   .   .. ..|  .| |    |. |.. | .  .... | ..|  .  |||.|||| .||.. .| .||   ..  .....|||||||.|
dkcsqywpl.kivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvg

RTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV
|||| |.... .  .. .. |   ..|| .|.||  ..|   || |.  |.|. 
rtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 666-910 1.4e-52 173.3 In-house 20-264 (283) alignment 
Range on Protein: 666-910
Range on HMM: 20-264/283.0
KPGMTMSCAKLPQNISKNRYRDISPYDATRVILKGN-EDYINANYINMEIpSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCH
 | .   .|   .|  |||...| |.|  || || . .||||| .| ..  |    ..||..|.|| .|  |||.| ...  . .||||   |  |.|| 
vpdldadiasadenkrknrnqeivpadqwrvelksesrdyinavfipvsk.sykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

QYWPEpTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQ--EKNESRpLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVL
||||.  ||  || . || . | .. ..| ....| ..   |..   |.  |.| | . |       .. |   . ...  |. |.|||||.|||||.|.
qyWPk.rGsedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavf

ITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
|.. ...  .  .  |    .|. || || |..||  ||..| |..|.
iaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 666-904 1.2e-35 117.7 In-house 39-273 (301) alignment 
Range on Protein: 666-904
Range on HMM: 39-273/301.0
KPGMTMSCAKLPQNisKNRYRD--ISPYDATRVILKGNEDYINANYINMEipssSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKC
|  .| | | ||..  |.||      |  | .|| .|.   | ||.|. .       ...|| ||||. |. ||| |        .|||. .||.   ||
kdhitesyaylpkd..khryptvPckPstavevivdGkrvPihanwipts....GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekc

HQYWPEPTGSS-SYGCYQVTCHSEEG--NTAYIFRKMTLFNQ-EKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNkragKEEPVVVHCSAGIGRT
..| |  ....   | .... ...|   |   . |.. . .  .| ..| .|  ||  |.|.|||    .  |..  |..     |.|.||||||||||.
eeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk....sekPivvhcsaGiGrs

GVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFV
  .|. |     .| .. .   . .. .|..|   .|| ||  ..
vafigteylareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_PTPN23_pd Subfamily PTPN23 667-911 1.4e-65 216.0 In-house 31-279 (288) alignment 
Range on Protein: 667-911
Range on HMM: 31-279/288.0
PGMTMSCAKLPQNISKNRYRDISPYDATRVILKGN-EDYINANYINMEIPSSsiiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQ
    .|.|    . .|||.||| ||| .|| |.|. .||||| ...   | .    ..|| |.||. |  |||.| .|| ||..|||... |.|. |...
earkrsiaiaklyseknrsrdilPyDhnRvklrgskDDYinAsfvkdlspgc...PdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdr

YWPEPTGS-SSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRN----KRAGKEEPVVVHCSAGIGRTG
|||| .|   ..| ..||..|..    .. |...|  ..... . .. .|. .||..|||.  ...|.|.  |..    ..   . |.|||||||.||||
YwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtg

VLITMETAMCLIECNQPVYP-LDIVRTMRDQRAMMIQTPSQYRFVCEAILKV
|.  . .|.  .| .. .   ...|...| ||  |.|. .|..|. ||.|. 
vfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
0049772 (Phosphotyrosine protein) phosphatases II 667-910 1.2e-40 135.6 In-house 34-278 (314) alignment 
Range on Protein: 667-910
Range on HMM: 34-278/314.0
PGMTMSCAKLPQNISKNRYRDISPYDaTRVILKG----NEDYINANYINMEipsssiiNQYIACQGPLPHTCTDF----------WQMT--WEQGSSMVV
| .|.  |.|. |..|||| || |.| .||||.|    . |||||.|..         ...||.||||..|. ||          |.|.  ... . ..|
peltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf.......lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdiv

M---------------------LTTQVERGrvkchqywpeptgsssygC----------YqvtchseegntayifrkmtlfnQ----EKNESRPLTQIQY
|                     |..  ..|                  .                                 .     .  .|.  .  .
msrdevladelsrLdaAlgKtpllildgng..................neptaadlellk......................eelydpelferlgikylr

IAWPDHGVPdDSSDFLDFVCHVRNKraGKEEPVVVHCSAGIGRTGVLITmeTAMCLIECnqPVYPLDIVRTMRDQRA-----MMIQTPSQYRFVCEAILK
| .||...| ...||..|. ....    |..||.|||.||.||||....  .|.... .   | . .... .| .|       .|... || |. ||.|.
ipvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvv..aaylmkll..gvsleealedvrlkRpinpnpgfieqleqyefilealle
subfamily_PTPN1_pd Subfamily PTPN1 668-910 1.7e-67 222.2 In-house 21-269 (290) alignment 
Range on Protein: 668-910
Range on HMM: 21-269/290.0
GMTMSCAKLPQNISKNRYRDISPYDATRVILK-GNEDYINANYINMEipssSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQY
 .... ||||.| ..|||||.|||| .|..|. .. |||||. ...|     .  .||  |||||.|.. |||| ||| |  ||||   ||....||.||
dfptreaklpenrnlnryrdvspydhsrikleradndyinaslvele....eakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WPEPTG--SSSYG--CYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGK--EEPVVVHCSAGIGRTG
||.     .  .    ..|.  ||| .  |. |.. | |.. .|.| ...  |..||| |||.  . ||.|. .||.  . .    |.|.||||||||.|
wPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsG

VLITMETAMCLIECNQPVYPLDIVR---TMRDQRAMMIQTPSQYRFVCEAILK
 .. ..| . ||| .. .  .|| .    .| .|  .|||. | ||   |||.
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_PTPRA_pd Subfamily PTPRA 668-914 6.3e-64 210.9 In-house 47-297 (330) alignment 
Range on Protein: 668-914
Range on HMM: 47-297/330.0
GMTMSCAKLPQNISKNRYRDISPYDATRVILKGN-----EDYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVK
  |.  |.  .|  |||. .| ||| .||||         ||||| .|.         ...||.|||. .|  |||.| ||| |. .||||   || . |
qatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfid....GykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeek

CHQYWPEpTGSSSYGCYQVTCHSEEGNTAYIFRKMTLF----NQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGR
|.||||.  |. .||  .|. . |.   .|  ||. .     ......|| ..|. . .||| ||| ..   |... .|....  . .|.|||||||.||
caqywPd.eGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGr

TGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEE
|| .|.... .  ..... |   ..|. .| ||. |.||  || |. ...|. |  
tGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyyly
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 669-915 5.9e-72 237.1 In-house 37-282 (288) alignment 
Range on Protein: 669-915
Range on HMM: 37-282/288.0
MTMSCAKLPQNISKNRYRDISPYDATRVILKG-----NEDYINANYINMEipssSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKC
 . . ..|..| .|||||.| ||| .|| ||.     ..|||||.||. |       ..||| ||||..|  |||.. .|. .| .||||  ||.|. ||
ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidge....kkkkkyiatqgPladtvndfWelvyenktstivmltelveggktkC

HQYWPEPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFnqEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLI
..|||.      ||  .||  ...  . .. ||. |    |.. . .|| || ||||||||... ..|...  | .    . .|..||||||.||||. |
eeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqadtgpiivhCsaGvGrtgtFi

TMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEG
......  .| .. .  ...|  .| |||...|| .|| |. |..|.. || 
aldalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieed
0040439 (Phosphotyrosine protein) phosphatases II 670-911 5.9e-80 263.7 In-house 2-245 (249) alignment 
Range on Protein: 670-911
Range on HMM: 2-245/249.0
TMSCAKLPQNISKNRYRDISPYDATRVILKG-----NEDYINANYInmeiPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCH
..|.|.|| |..||||.|| ||| .||.|.        |||||.||    . . | ...||.|||||.|. |||.| ||.|....||||. ||.||.||.
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi....dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekca

QYWPEpTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRA--GKEEPVVVHCSAGIGRTGVL
||||.  ||  || ..||. |.| .  |. |...| | ...|||  ..|||. |||||||.. .|.|||.  ||. ..  .|..||.||||||.||||..
qywpl.ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf

ITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV
|.. ......| .. | ....|...|.|| ...|.|.||||..||.|. 
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 670-910 8e-62 203.9 In-house 35-275 (315) alignment 
Range on Protein: 670-910
Range on HMM: 35-275/315.0
TMSCAKLPQNISKNRYRDISPYDATRVILK-----GNEDYINANYinmeIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCH
    |. ..| .||||..| |.| .||.|.      ..||||| |    |.|    . ||| ||||. .  |||.| ...  . .||.| . |  ..|| 
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasy....iksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcr

QYWPE-PTGSSSYGCYQVTCHSEEGNTAYIFRKMtlFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLI
||||.  . |  .| ..|.  | | .|  . ||.    .. .||| .|| |.  |||.||. ..| .| ..  |. ..  || ...||||||.|||||.|
qywPdrkadsvefGsikvellsleadtdgvarkl..vtrkseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvi

TMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
...  .  |. .. |  ...|...|..|  ..||  .| |. .|.|.
sidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 670-917 2.7e-30 100.3 In-house 24-263 (267) alignment 
Range on Protein: 670-917
Range on HMM: 24-263/267.0
TMSCAKLPQNISKNRYRDISPYDATRVILKGN-EDYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTqVERGRVkcHQYWP
|.|.    .|  .||. |  ||| |||||. . |.|||| |..    .    |..|. |.||  | |||...  .|. ...|.||. |  . .  ...||
tisqsiaeknqernrlddnlpyddtrvilrtkeeeyinasyve....gyktknafivtqdplkntitdfltvihdqkvpvivlltk.vftdni..rlfwP

EPTGSS-SYGCYQVTcHSEEGNTaYIFRKMTLFNQEKNESRPL-TQIQYIAWpdhGVPDDSSDFLD--FVCHVRNKRAGKEEPVVVHCSAGIGRTGVLIT
   | .  |    |  || | .    .. .||  . ||||    |   |  |    .  .   .|   |    .|.    . |.||.||.|.||.| ...
Pkmgqakkyqdltve.hslekee.ndyqiitlelkfknesahnvtlyyykkw...nintnnkpylkplfgilaknqlengnrPlvvacsdGvGrsGtflv

METAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAiLKVYEEGFV
... .  .  .. .   | .| .|.||  ...|  .| .. |  |  | || .
idsqleraktegvsdifdflrkirsqriglvdtkeryiyihel.laeyaegrl
0042113 (Phosphotyrosine protein) phosphatases II 671-911 5e-81 267.0 In-house 1-242 (245) alignment 
Range on Protein: 671-911
Range on HMM: 1-242/245.0
MSCAKLPQNISKNRYRDISPYDATRVILKGNE-----DYINANYInmeiPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQ
.|.|.|| |..||||.|| ||| |||.|.  .     |||||.|.    . . | ...||.|||||.|. |||.| ||.|....||||. .|.|||||.|
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyv....dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaq

YWPEpTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRA-GKEEPVVVHCSAGIGRTGVLIT
|||.  .|  || ..||. ||| .  |. |.... |  ..|||  ....|. ||||||||.....|||.  ||. .| ....||.||||||.||||..|.
ywpl.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfia

METAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV
. ......| .. | . ..|. .|.|| ...||||||||. ||.|. 
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0037934 (Phosphotyrosine protein) phosphatases II 671-910 5.6e-78 257.1 In-house 2-240 (243) alignment 
Range on Protein: 671-910
Range on HMM: 2-240/243.0
MSCAKLPQNISKNRYRDISPYDATRVILKGnEDYINANYINMEiPsssiinQYIACQGPLPHTCTD----FWQMTWEQGSSMVVMLTTQVERGRVKCHQY
.|.|.||.|.|||||.|| ||| .||.|.| .||||||.|..  |      ..||.|||||.|. |    ||.| ||.|....||||. ||.||.||.||
fsiallpenlsknrysdilpydhsrvkleg.sdyinanliyvt.p......rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPeptGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQE-KNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNK--------RAGKEEPVVVHCSAGIG
||   |.  || ..||. |||    |. |...| | . ....|  ....|..||||||||. .|.|||. .||.          . ...||.||||||.|
wp...gevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGVLITMETAMCLIecnqPVYPLDIVRTMRDQRAM-MIQTPSQYRFVCEAILK
|||.||.. . . |.     | ....|...|.|| . ..||||||||. ||.|.
RtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPRK_pd Subfamily PTPRK 671-910 3.4e-65 215.0 In-house 35-275 (314) alignment 
Range on Protein: 671-910
Range on HMM: 35-275/314.0
MSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINME-IPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPE
  .||  .| .|||. || .|| .||.|.  ..  ...||| . | |    ...|. ||||..| .|||.. ...... .||||  || ||||| .||||
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

PTGSssYGCYQVTCHSEEGNTAYIFRKMTLFN--QEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMET
 |    ||  .|.. . | .. .. | ... .  . ..| | . |.|...||||.||     .|..| .| .... .. ..||||||| ||||. |....
dtev..ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidi

AMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
 . .||... |    .|.|.|...  |..|  ||.|. ..|| 
vldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 671-910 4e-41 135.7 In-house 37-234 (392) alignment 
Range on Protein: 671-910
Range on HMM: 37-234/392.0
MSCAKLPQNISKNRYRDISPYDATRVILKGNEDYINANYINM-EIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGrvkchqywpe
 ..|. . |. ||||..| |||..||.|.  .|  . .|.|   |||    . |||.||| . .  |||.| ...  . ..|.|   |            
qtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd..........

ptgsssygcyqvtchseegntayifrkmtlfnqEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAM
                                   .. |  .| ..  |||..||  .| .| |.  |. .      |...|||||.|||||.|.... .
.................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvv

CLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
.  .  . |  ...|  .| .| .|.||  || |.  |.|.
ahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 671-918 2.8e-19 63.9 In-house 39-286 (303) alignment 
Range on Protein: 671-918
Range on HMM: 39-286/303.0
MSCAKLPQNISKNRYRDISPYDATRVILKgNEDYINANYINMEIPSSSIInqyiaCQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEP
.|  .. .|. |||. |.   | ..| |  .  || |.|....    .|.      | ||.||..|||||  ||    |..| |. |  ..  .  .|. 
vsknqfvknmdknrfvdvicldhskvkls.dssyihasyleldsskkail.....tqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn

TGSSSYGCYQVTC---HSEEGNTAYIFRKMTLFNQEKNEsrPLTQIQYIAWPDHGVPDD-SSDFLDFVCHVRN--KRAGKEEPVVVHCSAGIGRTGVLIT
     .    .     .  |    . .. ... | . .    |   .| |||   .| | |. |.  .  ..   ..  . .| |    .| ||.| .  
qdflkfeersirvgefkrvelgdgwvlkvlsvsngdyks..flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfal

METAMCLIECNQPVYPL-DIVRTMRDQRAMMIQTPSQYRFVCEAIL-KVYEEGFVK
.|||   .  .|.   |   . ..|. |   .|  ||. .|   .  .| ..|..|
fetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngick
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 672-911 5.1e-61 201.0 In-house 2-241 (250) alignment 
Range on Protein: 672-911
Range on HMM: 2-241/250.0
SCAKLPQNISKNRYRDISPYDATRVILKGNE-----DYINANYINMEIPSssiiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVkCHQY
| || |||  |||| || ..| .||.|. ..     ||||| ...    .    . .|| ||||..|  |||.| .|. |. .||||. .| ... .|||
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder....kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqy

WPEpTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAG-KEEPVVVHCSAGIGRTGVLITM
||   ..  ||  .|. .|.|  . |. ||. | ...|...| . |.....||| |||.     |... .|. ..   .. ||.|.||||.||.|  |..
wPv.ekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiai

ETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV
.. .  .. .. |   ......| .|  .... .|| || |.||| 
davlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 672-909 2.1e-31 104.1 In-house 36-268 (288) alignment 
Range on Protein: 672-909
Range on HMM: 36-268/288.0
SCAKLPQNISKNRYRDISPYDATRVILKGNEDY-INANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEP
.  .  .| ...||...   |.||| |. . |. |.|| .     |.   .. | .| ||  |   .|.|  |..   .|||.  .|.|. |  .|.|  
iidsfianptrdryenlprcditrvklsddpdfyiaanvvs....sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsk

TGSSSYGCYQvtCHSEEGNTAYIFR--KMTLFNQEKNESRP--LTQIQYIAWPDHGVPDDSSDFLDFVCHVrnkrAGKEEPVVVHCSAGIGRTGVLITME
 | .        |     . | | .  |..|.. .|.   .  . .. .  |.|.|||..   .| ..  .       ..|.|||.|||.|||| || . 
lGekarigrl..ctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlilil

TAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAIL
 |.  .  .  .    ..  .|..|   |||  || .|   .|
ialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvl
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 672-711 3.8e-06 20.7 In-house 32-75 (244) alignment 
Range on Protein: 672-711
Range on HMM: 32-75/244.0
SCAKLPQNISKNRYRDISPYDATRVILK----GNEDYINANYIN
. | |  | .|||| .| |.| |||||        ||||||||.
tnavlsanatknryinilpfdetrvilssskkegsdyinanyiq
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 673-910 1.6e-61 202.8 In-house 22-266 (274) alignment 
Range on Protein: 673-910
Range on HMM: 22-266/274.0
CAKLPQNISKNRYRDISPYDATRVILKG------NEDYINANYINMeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQY
  ... . .||||..| | . .||.|.       . .|||||||      .   . |.| |||||.| .|||.| ... ....||||   |. . ||..|
eldvfgsqtknryktilPnensrvllesessededssyinanyikG...ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavy

WPEPTGS---SSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKneSRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEE---PVVVHCSAGIGRTG
.|. ..      ||  ... ..   .  |  ||..| ..|.  .| .. . | .|||| .||| . .||.| .|...|  ...   ||||||||||||||
fPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtG

VLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
. |... |.  .. .. |  | ||  .| .|  |.|| .||... .|. .
cfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_CG7180_pd Subfamily CG7180 673-911 1e-39 130.9 In-house 36-289 (296) alignment 
Range on Protein: 673-911
Range on HMM: 36-289/296.0
CAKLPQNISKNRYRDISPYDATRVILKGN-----EDYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRvKCHQYW
..   .|. |||. .. ||| .||.|.       .||||| |..    |    ..||  ..|  .|  .||.. .....| ||.|| . .  . ....||
gglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvd....sflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsyw

PEPTgSSSYGCYQVTCHSEEGNTAYIFRKMTLFN----------QEKNESRPLTQIQYIAWPD-HGVPDDSSDFLDFVCHVRNKRA-----GKEEPVVVH
|. .    ||   |   .|.  ..   |.. |            |.| | | ....|.  |.  . ||  .. .....  ||  |       .|.||||.
pnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvv

CSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV
.| | .|.|| .... .. |.| .. |   . |.|.| .|  ....  .|... . .|. 
ssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 673-712 5.3e-06 20.0 In-house 41-86 (440) alignment 
Range on Protein: 673-712
Range on HMM: 41-86/440.0
CAKLPQNISKNRYRDISPYDATRVILKG-----NEDYINANYIN-M
 | ||.|  |||||.|  || .||.|.      ..||||| ||| .
iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 674-910 4.2e-61 201.6 In-house 38-274 (515) alignment 
Range on Protein: 674-910
Range on HMM: 38-274/515.0
AKLPQNISKNRYRDISPYDATRVILK-----GNEDYINANYinmeIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWP
|.   | .||||..| ||| .||.|.      ..||.|| |    |||    . ||| |||.. .  |||.. ...  . ..|.| . |  ..|| .|||
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasy....ipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWP

E-PTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKneSRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMET
. |. |  .| ..|   | |  |  | ||.|.  ...  || .|| ..  |||.||| ..| .| ..  |. ..   . |...|||||.|||||.|... 
dkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisids

AMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
 .  ..  . |  ...|. .|..|  ..||  || |. .|.| 
vvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 674-910 1.2e-55 183.8 In-house 46-282 (297) alignment 
Range on Protein: 674-910
Range on HMM: 46-282/297.0
AKLPQNISKNRYRDISPYDATRVILKGNE-----DYINANYINmeipssSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRvKCHQYWP
|.   |..|.||..| |||  ||.|.  .     ||.|| ...      .. ...|. | | . |  |||.| ...  |..|||. . || . || .||.
aekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvk......gnkhrlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs

EpTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPD--DSSDFLDFVCHVRNKRAGKEE-PVVVHCSAGIGRTGVLITM
. .|....|   |. .| .  . .| |.... ...    | . | |.. |||. |.   . | .|...  ||..  ...| |..|||.||.||||||.|.
d.kgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGvGrtgvllti

ETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
.  .. .. .. |  ...|. .|..|  ..||  ||.|| .|.|.
dsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 674-909 6.5e-44 144.9 In-house 3-238 (239) alignment 
Range on Protein: 674-909
Range on HMM: 3-238/239.0
AKLPQNISKNRYRDISPYDATRVILKG-----NEDYINANYINMEIPSSsiiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWP
||   | .|||| .|  || .||.|.        |||||.|.     |    . ||| || .  .. |||.| |..   ..||||  .|  . |||||||
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgsp...kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp

EPTgsSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETA
. |  | |   .|| .  |  . || | . . .  . | | . | ..  |||.|||. ..  | .  .. .       | |.|||||.|||| .. ... 
dst..skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam

MCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAIL
.   . .. |  .. |...|..|  |.||  || |.  |.|
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 675-910 5.7e-44 145.0 In-house 3-238 (239) alignment 
Range on Protein: 675-910
Range on HMM: 3-238/239.0
KLPQNISKNRYRDISPYDATRVILKG-----NEDYINANYINMEIPSSsiiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPE
|   | .|||| .|  || .||.|.        |||||.|.     |    . ||| || .  .. |||.| |..   ..||||  .|  . |||||||.
kkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgsp...kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

PTgsSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAM
 |  | |   .|| .  |  . || | . . .  . | | . | ..  |||.|||. ..  | .  .. .       | |.|||||.|||| .. ... .
st..skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml

CLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
   . .. |  .. |...|..|  |.||  || |.  |.|.
rqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 676-728 2.7e-08 27.9 In-house 45-95 (95) alignment 
Range on Protein: 676-728
Range on HMM: 45-95/95.0
LPQNISKNRYRDISPYDATRVIL--KGNEDYINANYINmeipSSSIINQYIACQG
   || |||. .| |||||||.|  | . ||||| ...      .  | |||.||
seanipknrflnifpydatrvvlttkrdsdyinacfvd....gyarkncyiaaqg
subfamily_ptpA1_pd Subfamily ptpA1 677-869 1.3e-37 124.6 In-house 45-253 (418) alignment 
Range on Protein: 677-869
Range on HMM: 45-253/418.0
PQNISKNRYRDISPYDATRVILKGNEDYINANYINMEIPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSY
 .| ||||| .| | . ||| ||  .|   ..||| .    .  .|.|. ||||| | .|||.| ||.   ..|||. . |  |.|| .||||  |   .
khntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

----------GCYQVTCH--SEEGNTAYIFRKMTLFNqeKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKR------AGKEEPVVVHCSAGIGR
          | | |      .. .   | |.. |    . |.| .|| ||  |||| .|| .  | ...  . |..      . .. |..||||||.||
siygngnevfgtysvelveviqdpereiitrnirltf..egetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgr

TGVLITMETAM
|| . |    |
tgtfctavimm
subfamily_CG42327_pd Subfamily CG42327 677-840 4.7e-30 99.4 In-house 25-193 (319) alignment 
Range on Protein: 677-840
Range on HMM: 25-193/319.0
PQN-ISKNRYRDISPYDATRVILKG-----NEDYINANYINMeiPsSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEP
|     |.|. .. |   |||.|.      .. |..|.|.    .  .  |.|||.| .|  . .|||.. ||| | ..| ||   | |  .| .|.|  
PvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrG..y.ddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtk

T---GSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYiAWPDHGVPDDSSDFLDFVCHVRNK
    . |.|| ..||    | .  |.   . | . .|.|||.||   |  |.. .|| . . ..  . .||. 
etldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 678-910 1.8e-58 192.7 In-house 19-262 (270) alignment 
Range on Protein: 678-910
Range on HMM: 19-262/270.0
QNISKNRYRDISPYDATRVILKGN-----EDYINANYINmeiPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTG
..   |||.|| |  ||||.|.         ||||||..     ..  ..||| .|||| | ..||.| ||. .. .||.|  .|.|| || .|||. ..
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvr...GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepk

S---SSYGCYQVTCHSEEGNTAYIFRKMTLFnqEKNESRPLTQIQYIAWPDHGVPDDSS------DFLDFVCHVRNKRAG--KEEPVVVHCSAGIGRTGV
.    ..|  .|.  ||| .. ||.....|   || |.| |.  .| .||||||| ..       . |  . .||. .    |.||..||||||.||||.
ekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGt

LITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
||....|..|.| .. | .| |.. .| .|  ..|.| ||.|. .|...
lialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 678-909 1.1e-54 180.2 In-house 2-236 (237) alignment 
Range on Protein: 678-909
Range on HMM: 2-236/237.0
QNISKNRYRDISPYDATRVILKG---NEDYINANYINMeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSS
.|  |||| .|  || .||.|||   . |||||.|..         ..|||.||||  .| ||||| |..  |..||||  .|. ..|||.|||.    .
enkiknrygnivaydhsrvvlkgagsgsdyinatylkg...fdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpa

SYGCYQVTCHSEEGNTAYIFRKMTLFNQE-KNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAG--KEEPVVVHCSAGIGRTGVLITMETAMCL
.|| . |. . .|  . |  | ..|...  ..| | . | |. .|||.|||. .. .| |  .. |.     .  | ..|||||.||||... ... .  
aygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrq

IECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAIL
 . .. |   . | .. ..|  .|||  || |. ..||
akekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 678-911 1.6e-48 159.8 In-house 53-282 (290) alignment 
Range on Protein: 678-911
Range on HMM: 53-282/290.0
QN--ISKNRYRDISPYDATRVILK--GNEDYINANYINmeipssSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGS
.|  . ||||.|.   | ||||||  .. ||. |||..       .   .|  ||.|  |  |.|.|  ... ...|||   .| |. ||.||.||  | 
kntefkknrykdvvcndktrvilkdGydGdyvhanyvk......GlkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe

S-SYGCYQVTCHSEEGNTAYIFRKM-TLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKrAGkeePVVVHCSAGIGRTGVLITMETAMCL
  ..| . |.|  |. . | | .|. .. ....  .  |  .. ..|||. |.  .  .|  .  .|.  .|   |||||||||||||| ....|... .
vltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka.sG...pvvvhcsaGiGrtGtfvaievglqi

IECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV
.   . . .||.||..|. |.  .|   ||  . |..|..
lldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 678-911 9.9e-42 137.8 In-house 34-269 (285) alignment 
Range on Protein: 678-911
Range on HMM: 34-269/285.0
QNISKNRYRDISPYDATRVILKGN-EDYINANYINMEIPSSSiinQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSS-S
 |   ||| |.   . |||.||    ||| |... |     |    ||. ||||| | .|||.| ...  . |.|| | .| |  ||  |.||  |    
anpdlnryadvrcieetrvvlknhdrdyihaswmrmpgkdqs...tyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvk

YGCYQVTCH--SEEGNTAYIFRKMTLFNQEKNESRPL--TQIQYIAWPDHGVPDDSSDFLDFVCHVRnKRAGKEEPVVVHCSAGIGRTGVLITMETAMCL
.| |..|     ||  .  |.  .|. | |   | ||   ..|   |||.  |.|.  ....   |. |   ||.|..||||||.|||  .. .. |   
fgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvk.kvnpkekpicvhcsagvgrtatfvgidyatir

IECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV
|  |  .  ||||| ||  |   .|.  |. |.   ... 
imenpniemldivremramrfqavqshmqflflyvvlmey
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 678-915 2.3e-39 129.8 In-house 54-292 (305) alignment 
Range on Protein: 678-915
Range on HMM: 54-292/305.0
QNISKNRYRDISPYDATRVILKG--NEDYINANYINMEI-PSssiiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSS
 .|.||||.|.   | . | |.     ||| |||.   . |     ...|..|||| .|  .|| |  ..    .|||   || |..|| ||||   |  
iaitknryqdvpcqdqsavkldkpspsdyihanyvgcpmipe....krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgek

S---YGCY--QVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRnkraGKEEPVVVHCSAGIGRTGVLITMETAM
     |.   .|.        | |   .  ..   ...  . ..|.  ||| |||      |...  .|    | . |.|||||||||||| ....|  .
lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair....gskvpivvhcsagigrtgtivaieyil

CLIECNQPVYPL-DIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEG
  |  |.|. |. ..|...|||||. ||.  || |.   .|. . | 
ekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek
subfamily_egg_pd Subfamily egg 678-912 7.9e-26 85.4 In-house 39-270 (307) alignment 
Range on Protein: 678-912
Range on HMM: 39-270/307.0
QNISKNRYRDISPYDATRVILKG-----NEDYINANYINmeipSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERgrVKCHQYWPEPT-
 |  | | . .   | .|| |.       .|.| ||...       ..|..| .| ||  |  |||.| ...    .||||...|    .|. |||    
nnlekarskrvhckdssrvklelrrGqylddfihanrvk....Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkaes

GSSSY--GCYQVTCHSEEGNTAYIFR--KMTLFNQEkNESRPLTQIQyiaWpDHgvpDDSSDFLDFVCHVRNKRAgKEEPVVVHCSAGIGRTGVLITMET
 |  .  | .....   . ..  .||  |. |   . .| | |   |   . |    . |||    .  .|  |    .||||..  |. ....|...|.
dslvtvpGslrienlkvdskadplfrvtklklvGgd.deerflehwq...g.dv...nnssdvysplrvlrklrn.lskpvvvqdilGvskaatlvaiei

AMCLIECNqPVYPLDIVR---TMRDQRAMMIQTPSQYRFVCEAILKVY
|.. .    |..   . |    .| .| . .... .| ||   .| ..
allsllrG.pitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
Y_phosphatase Protein-tyrosine phosphatase 679-909 5.6e-80 263.5 Pfam-A 1-234 (235) alignment 
Range on Protein: 679-909
Range on HMM: 1-234/235.0
NISKNRYRDISPYDATRVIL---KGNEDYINANYINMEIpSssiINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWP-EPTGSS
| .||||.|| ||| ||| |   .|..|||||||...   .    ...||.||||..|. |||.| |.. ....||||. .|.||.||.|||| |  .| 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.e...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

SYGCYQVTCH-SEE-GNTAYIFRKMTLFNQEKN-ESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCL
.|| ..|..  .|.  ...|..||..| ..... |.| ..|..| .|||||||......||..  |..... |..|||||||||.||||.......... 
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

IECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAIL
.| .. |  |.||...| ||..|.|. .|| |...|||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 679-909 5.6e-80 263.5 In-house 1-234 (235) alignment 
Range on Protein: 679-909
Range on HMM: 1-234/235.0
NISKNRYRDISPYDATRVIL---KGNEDYINANYINMEIpSssiINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWP-EPTGSS
| .||||.|| ||| ||| |   .|..|||||||...   .    ...||.||||..|. |||.| |.. ....||||. .|.||.||.|||| |  .| 
nkkknRykdilpydktrvklkgsegpsdYInAnyvkgyk.e...kkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

SYGCYQVTCH-SEE-GNTAYIFRKMTLFNQEKN-ESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCL
.|| ..|..  .|.  ...|..||..| ..... |.| ..|..| .|||||||......||..  |..... |..|||||||||.||||.......... 
tygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

IECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAIL
.| .. |  |.||...| ||..|.|. .|| |...|||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 679-913 1.7e-52 173.0 In-house 1-172 (182) alignment 
Range on Protein: 679-913
Range on HMM: 1-172/182.0
NISKNRYRDISPYDATRvilkgNEDYINANYINMEIPSSSiinqYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTtqvergrvkCHQYWPeptgsssygc
|..||||.|| ||| .|     . ||||||.. .  |..     .||.||||..|. ||..| .|.| ...|.||         ...|||          
nldknrysdilpydhsr.....dldyInanlylgslpatr....fiatqgpllstvadflrmlkelgittivnlt.........eelywp..........

yqvtchseegntayifrkmtlfnqeKNESRPLTQIQYIAWPDHGVPDdSSDFLDFVCHVRNkragKEEPVVVHCSAGIGRTGVLITMEtamcLIECNQpV
                         ... |  .|..|. ||||||||  ...|||.  |..    ...||.||||||.||||.|. .     |..... |
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaay....lmkklg.v

YPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYE
 . ..|...| .| .|..||.||.|.  |.| ...
sleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 679-910 2.3e-44 146.6 In-house 48-277 (439) alignment 
Range on Protein: 679-910
Range on HMM: 48-277/439.0
NISKNRYRDISPYDATRVILK-----GNEDYINANYINMEIPSssiiNQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRvkchqYWPEpTGS
. .||||.|....| |||.|.         |||||||.         . |||.|||  .|. |||.. .|. .. .||||  ||  .     |||   . 
dqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyydd....klyiatqgpkkettddfwrlviekktvtivmltnlvesyk.....ywps.dae

SSYGCYQVTCHSEEGNTAYIFRKMTLFNQEK--NESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKE-EPVVVHCSAGIGRTGVLITMETAMC
  ||   | .  .     |. | . .||.    .  | . |..||||||. || ..|  |||.  .      .|  |||||||||.|||| .|... |. 
vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdiale

LIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
 .  .. |    ||. .|.||  |.|.  || |. .|.|.
qlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 679-771 4.1e-26 86.5 In-house 47-154 (350) alignment 
Range on Protein: 679-771
Range on HMM: 47-154/350.0
NISKNRYRDISPYDATRVILK-------------GNEDYINANYINMEIPSSSIINQY--IACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKC
  .||||..| ||. .||.||               .|||||||.... .| .|  ..  || |.||| |  ||...  . .  ....||..|| .. ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

HQYWPEPT
..||.| .
yrYWqegs
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 679-771 1.2e-14 48.4 In-house 48-157 (349) alignment 
Range on Protein: 679-771
Range on HMM: 48-157/349.0
NISKNRYRDISPYDATRVILKG-------------------NEDYINANYINMeiPSSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERG
  .||||.|| ||. .||.||                     .|||||||...  .  |. ..||| | ||| |  ||...   .|  .|. |. . | .
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkl..trisvekkyiatqaPlPstvddfykvillngvklvlsLnddkels

RVKCHQYWPEPT
  ||..|| | .
lekcdiywqels
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 681-916 1.9e-30 100.6 In-house 45-281 (312) alignment 
Range on Protein: 681-916
Range on HMM: 45-281/312.0
SKNRYRDISPYDATRVILKGNED-YINANYINMeipsSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSY---
  ||| .|  .|  |  | |.|. || ||....     .  ......||||  ||| |||..   ||. ...|.. || |  || .|  .  |       
dlnrypniqcwdrgrftlagdenfyihanfvki....ctkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

GCYQVTCHSEE-G---NTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRagkeEPVVVHCSAGIGRTGVLITMETAMCLI
  |   |   | |   .     | . .  .   .   | . |. .|||||.||     | ..  |.. .     ||. |||||.|||| |. .|. .. .
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvgrtgtlaliesmiaal

ECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILKV-YEEGF
   .     |.   .| .||  ...  || ..  ..|.. | .|.
rhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 688-909 3e-25 84.0 In-house 27-256 (290) alignment 
Range on Protein: 688-909
Range on HMM: 27-256/290.0
ISPYDATRVILKGNEDYINANYINMEIPSSSIINQYIACQGPLPH-------TCTDFWQMTWEQGSSMVVMLTTQVERGRV----KCHQYWPEPTG-SSS
..   ||||.|||    .| .||  .  . .   . |. | |. .       |  .|| |  .  .  ||||    |. .      | .| ||  | .  
vpLveatrvvLkgygkrfnddyiHAnrvtcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelk

YGCYQVTCHSEEGNTAYIFRKMTLfNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAgkeePVVVHCSAGIGRTGVLITMETAMCLIE-C
..  .| | | | .   . |.... . ...|   .|  ..  | .  |..|.  .|. . .|.....    ||.|||  || |  .| ... .. .|   
fkgltvkCkskekeddvetRelvv.kfddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt....pvivHcvdGiSrsAalaaiilgyQkiaet

NQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAIL
.. |   |.. ..| |||..|... .. ||  .|.
sgsvkledvlkalrkqralaitsalelafvdagiv
0044763 (Phosphotyrosine protein) phosphatases II 690-914 4.2e-37 122.8 In-house 1-173 (178) alignment 
Range on Protein: 690-914
Range on HMM: 1-173/178.0
PYDATRVILKGNED-----YINANYINmeiPSssiinQYIACQGPlphtcTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGsssygcyqvtch
|.| |||.|   |.     ||||..|    |       |.....|      |.... .|.| ...|.||. .|.|..||..|||| .|            
pldrtrvllsnleglersdyinaseil...pg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag............

seegntayifrkmtlfnqeknesrplTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLItmetA----MCLiecnqPVYP
                           | ..| .||||||| .. ||.||  ... .. |..||.||||||.||.|.|.    |    ..|      . .
..........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlv....aaylmkkl.....glsl

LDIVRTMRDQRAmMIQTPSQYRFVCEAILKVYEE
 .... .| .|  ....|.|.|...|  |....|
eeaielvrerRp.ivpnpgqlrqLyefelrllke
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 690-823 1.1e-07 26.2 In-house 4-126 (130) alignment 
Range on Protein: 690-823
Range on HMM: 4-126/130.0
PYDATRVIlkgNEDYINANYINMeipsSSIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTqVERGrvkcHQYWPEPTGSSSYGCYQVTCHSEEGN
... .|.    ...||||... .    .   ..|.  | ||  |..|||.|  |.   ..|.| . ||       .|||.      |    .   ..  .
efevsrlq...gntyinasfvGl....lgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs.veee....deywpdsePlewyeediivtltdrde

TAYIFRKMTLFNQEKNE-SRPLTQIQYIAWPDHGV
  .|  .    ... ||  . || .|   ||  | 
fknikasnleiesdlneshqaltmfqisnwpsdgt
0046846 (Phosphotyrosine protein) phosphatases II 698-911 9.8e-48 157.5 In-house 8-172 (176) alignment 
Range on Protein: 698-911
Range on HMM: 8-172/176.0
LKGNEDYINANYINMEIpsssiinqYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPTGSSSygcyqvtchseegntayifrkm
| .. ||||||.| .          .||.|||||.|. ||..| .|.| ..||.||. || ||.||..|||| .. .                       
ldldldyinanlilgsr........piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi......................

tlfnqeknesrpltQIQYIAWPDHGVPDDsSDFLDFVCHVRNKRAGKeEPVVVHCSAGIGRTGVLITMEtamcLIECNQPVYPLDIVRTMRDQRA-MMIQ
              |.... ||||||||. ...|...  .|. .  . .||.|||||||||||.|. .     |.|... . ........|.||  ...|
..............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq

TPSQYRFVCEAILKV
||.||||. |..|..
tpeQyrflyefelll
0043147 (Phosphotyrosine protein) phosphatases II 701-905 4.3e-45 148.8 In-house 4-154 (172) alignment 
Range on Protein: 701-905
Range on HMM: 4-154/172.0
NEDYINANYINMEIpsssIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQvergrvkchqywpeptgsssygcyqvtchseegntayifrkmtlF
..|||||.|... .    |....||.||||..|. |||.| .|.| ...|.||.                                             .
gsdyinasyldlyy....ipdrfiatqgplrntladfwrmlkelgithivnltel............................................l

NQEKNESRPLTQIQYIAWPDHGVPdDSSDFLDFVCHVRN-KRAGKEEPVVVHCSAGIGRTGVLITMETAMcliecnQPVYPLDIVRTMRDQRAMMIQTPS
.  ....|   |..|. ||||||| ... .|.|.  ...     ...||.||||||.||||.|. .   .      . . ....|...|..| ...|.||
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYRFVC
||||..
qyrfly
0051429 (Phosphotyrosine protein) phosphatases II 702-913 4.2e-54 179.3 In-house 4-226 (272) alignment 
Range on Protein: 702-913
Range on HMM: 4-226/272.0
EDYINANYINMEiPSSSIINQYIACQGPLPHTCTDFWQMtWEQGSSMVVMLTTQVERGRVKCHQYWP-----------EPTGSSSYGCYQVTCHSEEGNT
..||||.....   .  . . .....||||.|. |||.. .|.| ...|.|.. .||||.||..|||           . . . .||.. ||..|||  .
sgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

AYIFRKMTLFNQ-EKNESRPLTQIQYIAWPDHGVPDDSsdFLDFVCHVRNkragkEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVY--------PL
 || |...| ..   .|.| .....|..|||||||...  .|... ....     ..||.||||||..|||... .   .  .. .. |         ..
dyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

DIVRTMRDQRAMMIQTPSQYRFVCEAILKVYE
..|. .|.||. ..||. ||.|..||.|....
eaveelraqrpgavqteeqylflyeallellr
0036282 (Phosphotyrosine protein) phosphatases II 702-905 2e-49 162.9 In-house 2-163 (174) alignment 
Range on Protein: 702-905
Range on HMM: 2-163/174.0
EDYINANYINMEIPSSsiinQYIACQGPLPhtctdFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEptgsssygcyqvtchseegntayifrkmtlfn
.|||||..... . ..     .||.||||.     ||.| .|.|...||||.. .|.|..||..||||                                
sdyinaspldlsyitp....rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................

QEKNESRPLTQIQYIAWPDHGVPDDSSdFLDFVCHVRNKRAG-KEEPVVVHCSAGIGRTGVLITMETAMCLIEcNQPVYPLDIVRTMRDQRAMMIQTPSQ
  . ..|   |..|. ||||||||.|  .|.||. |.. ..  .. ||.||||||.||||.|. .   ..... . .|  ||.||..| || .|.|||||
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YRFVC
|||. 
yrfly
0051082 (Phosphotyrosine protein) phosphatases II 702-908 4.5e-33 109.3 In-house 3-149 (151) alignment 
Range on Protein: 702-908
Range on HMM: 3-149/151.0
EDYINANYINmeiPSssiinqYIACQGPLPhtctDFWQMTWEQGSSMVVMLTTQVERGrvKCHQYWPEPTgsssygcyqvtchseegntayifrkmtlfn
.||||..|.    .       .....|||.    ||... .|.| ...|.|.. .|||  .|..|.||                                
sdyinfsyvt...gg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..............................

qeknesRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNkraGKEEPVVVHCSAGIGRTGVLItmetAMCLIECNqpVYPLDIVRTMRDQRAMMIQTPSQY
      . ...|... |||.|.|.    .|.|. ....    |. ||.||||||.||||.|.    |. |. ..  | . .... .| .| ...|.. |.
......ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlv....alylmllg..vsleealeeyrlkrpgvvqpnqqf

RFVCEAI
.|.  |.
lfqlfal
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 718-788 1.8e-07 24.8 In-house 233-300 (440) alignment 
Range on Protein: 718-788
Range on HMM: 233-300/440.0
SIINQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERgrvKCHQYWPEPTGSSSYGCYQVTCHSEEG
|  | .|| | ||  |  |||..  .   | ..||    ..    |  |||  | | ..| . |  .  | 
skknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsen
0049260 (Phosphotyrosine protein) phosphatases II 720-905 6.4e-43 141.4 In-house 8-143 (152) alignment 
Range on Protein: 720-905
Range on HMM: 8-143/152.0
INQYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWpeptgsssygcyqvtchseegntayifrkmtlfnqeknesrpltQIQYIAWP
 ...||.|||.|.|. |||.| .|.| . .||||. .|.|..||.||.                                            |.... ||
pfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpwp

DHGVPDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMcliecnQPVYPLDIVRTMRDQRAMMIQTPSQYRFVC
||||||.|  .|...  ..  .  |..||.||||||.||||.|. .   .      . | ....|. .| .| .....|.|.||. 
DhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 722-904 9e-22 72.2 In-house 5-195 (198) alignment 
Range on Protein: 722-904
Range on HMM: 5-195/198.0
QYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEP-TGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEK--NESRPLTQIQYIAW
.|||.| || .| .||||| || ||  .||.  .     .    |||   .|.. ||.  ||...   .  |    . | |.      .| ... |. .|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVPDdSSDFLDFVCHVRNK----RAGKEEPVVVHCSAGIGRTGVLITMETAMCLIEC-NQPVY-PLDIVRTMRDQRAMMIQTPSQYRFV
 ..  |.  . |. ||   |.        |. ||.|||| | | |||.....  .   |  .  |   ... . .|. |  .| .  .| |.
kekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 722-904 9.2e-22 72.2 In-house 6-196 (199) alignment 
Range on Protein: 722-904
Range on HMM: 6-196/199.0
QYIACQGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEP-TGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEK--NESRPLTQIQYIAW
.|||.| || .| .||||| || ||  .||.  .     .    |||   .|.. ||.  ||...   .  |    . | |.      .| ... |. .|
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVPDdSSDFLDFVCHVRNK----RAGKEEPVVVHCSAGIGRTGVLITMETAMCLIEC-NQPVY-PLDIVRTMRDQRAMMIQTPSQYRFV
 ..  |.  . |. ||   |.        |. ||.|||| | | |||.....  .   |  .  |   ... . .|. |  .| .  .| |.
kekttpn.valfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 727-910 8.1e-19 62.2 In-house 97-286 (302) alignment 
Range on Protein: 727-910
Range on HMM: 97-286/302.0
QGPLPHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWPEPT-GSSSYGCYQVTCHSEEGNTAYIFRK--MTLFN-----QEKNE--SRPLTQIQYI
  |   |.  .| .  .   ..|| |.. || .  || .|. .   |   .| | |.  | . . .    |  ..|..     ..|..   ...  ... 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

AWPDHGVPDDSSDFLDFVCHVRNKRagkeEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
|||||| |...   || . .    .    . |.||||||.|||| |...   . |   ..    |.||  .|. |   .|. .|  ..   . |
awpdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtk
subfamily_hpo-7_pd Subfamily hpo-7 731-916 1.7e-16 54.9 In-house 44-231 (263) alignment 
Range on Protein: 731-916
Range on HMM: 44-231/263.0
PHTCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWP-EPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSD
  |   |.|.   .... ||||.   | |..|| .|.| |  .   .   .|..     ..    ....   .|| . . ... .|  |...  | .. .
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpelare

FLDFVCHVRNKRagkeePVVVHCSAGIGRTGVLITMETAMC--LIECNQ-PVYP---LDIVRTMRDQRAMMIQTPSQYRFVCEAILKVYEEGF
 |  .  .|| .     ..|||||.||||.     .|..    .   .. .      | ... .| .|.  |.|| |  |    .|..  . |
ilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 733-911 6.7e-19 63.0 In-house 40-220 (255) alignment 
Range on Protein: 733-911
Range on HMM: 40-220/255.0
TCTDFWQMTWEQGSSMVVMLTTQVERGRVKCHQYWP-EPTGSSSYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFL
|   |.|.   .... ||||.   | |..||..|.| |  .   .   .||.     .     ...|.   || . . ..  .|  |...  |... . |
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

DFVCHVRNKRagkeePVVVHCSAGIGRTGVLITMETAMC--LIECNQ-PVYP---LDIVRTMRDQRAMMIQTPSQYRFVCEAILKV
  .  ||. .     .||||||.||||.  .. .| .    .   .. .      | ... .| .|.  |.|| |  |    .|..
nilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
0048076 (Phosphotyrosine protein) phosphatases II 775-909 2.3e-28 94.1 In-house 12-140 (145) alignment 
Range on Protein: 775-909
Range on HMM: 12-140/145.0
SYGCYQVTCHSEEGNTAYIFRKMTLFNQEKNESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKeEPVVVHCSAGIGRTGVLItmetAMCLIEC
 .|.. .... |.     | .  .| . .....|  .|..|. ||||||||.....|.|.  ... .. . .||.||||||.||||.|.    |..|. .
ylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlv....aaylmll

NQpVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAIL
.. | . .... .| || .....|.|.||..|..|
lg.vsleealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 804-906 5.4e-25 83.2 In-house 48-139 (144) alignment 
Range on Protein: 804-906
Range on HMM: 48-139/144.0
KnesrpLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAgKEEPVVVHCSAGIGRTGVLITMEtamcLIECNQpVYPLDIVRTMRDQRAMMIQTPSQYRF
       .|.... ||||||||.....|.|.  ... .. ...||.||||||.||||.|...     |. ... . . .... .| .| .....|.|.||
e.....giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleealalvrsrrpgavpnpgqlrf

VCE
..|
Lle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 805-911 3.6e-19 63.4 In-house 86-193 (440) alignment 
Range on Protein: 805-911
Range on HMM: 86-193/440.0
NESRPLTQIQYIAWPDHGVPDDSSDFLDFVCHVRNKR-AGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRF
 ||| | | .| .|||.|||  ..  | ..  | . .    . |..|||||| |||||.|.... .   . .. .  . .. .||..|  |.||| || |
iesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

VCEAILKV
| ||.|. 
vheavleg
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 810-908 3.1e-08 27.3 In-house 220-340 (349) alignment 
Range on Protein: 810-908
Range on HMM: 220-340/349.0
LTQIQYIAWPDHGVPDDSSDFLDFV----------CHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMCLIECNQ-PVYPLD-----------IVRTM
| |.|.  |.| ..  .   .|  .                 . .  ...|||||| ||||||.|..  . ..|  |     ..           || ..
llqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnel

RDQRAMMIQTPSQYRFVCEAI
| ||  |.|  .|. .. ||.
rkqrismvqnlaqfiaiyeal
PTPc_DSPc_SM00012 811-909 3.8e-32 106.0 In-house 3-104 (105) alignment 
Range on Protein: 811-909
Range on HMM: 3-104/105.0
TQIQYIAWPDHGVPDDSSDFLDFVCHVRNKRAGKE--EPVVVHCSAGIGRTGVLITMETAMCLIECN-QPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEA
....| .|||||||..|...|... .|....  .|  .|||||||||.||||.......... .| . . |  ..||. .|.||. |.||  || |...|
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra

IL
.|
ll
subfamily_VSP_pd Subfamily VSP 811-905 3.1e-06 21.2 In-house 94-192 (212) alignment 
Range on Protein: 811-905
Range on HMM: 94-192/212.0
TQIQYIAWPDHGVPDdSSDFLDFVCHVRNKRAGKEEP-VVVHCSAGIGRTGVLITME--TAMCLIECNQPVYPLDIVRTMRDQRAM--MIQTPSQYRFVC
 ... |   || ||   ...| |  .|..  .  ..  ...||  | |||| ..     ..  . . .. .. .   || ...  .   .|||||.|.| 
nrvkriliddhnvpk.leellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfgerrtdktegekfqGvqtpsqkryvg
PTEN_1 812-904 1.3e-12 42.9 In-house 94-185 (196) alignment 
Range on Protein: 812-904
Range on HMM: 94-185/196.0
QIQ--YIAWPDHGVPDDSSDFlDFVCHVRNKRA-GK-EEPVVVHCSAGIGRTGVLItmetAMCLIECNQpVYPLDIVRTMRDQR-AMMIQTPSQYRFV
...   . ..|||.|. |. | |... . . .   . .. |.||| ||.||.|...    |..|.....   . . .. .|..| ......||| |..
gveylhfpieDhgapslself.dicksfiewllsdpngnvVlVHCkaGlgRsGtvv....aayLmykgk.ltadeAlelvrekRppgapnspsqerll
0038934 (Phosphotyrosine protein) phosphatases II 813-905 1.3e-11 40.0 In-house 80-170 (194) alignment 
Range on Protein: 813-905
Range on HMM: 80-170/194.0
I--QYIAWPDHGVPDDSSDFLDFVCHVRNKR-AGKEEPVVVHCSAGIGRTGVLItmetAMCLIECNQPvYPLDIVRTMRDQRAMMIQTPSQYRFVC
|    . .||.|.. . .  |.|.  |  .  . ... |.||| ||.||||.|.    |  ||....   . . ....|. |  .|....... ..
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlv....aaYLiyrlgm.saeeAialfrekRpgaipnqdyleall
subfamily_PTPDC1_pd Subfamily PTPDC1 815-906 3.7e-10 34.5 In-house 87-170 (182) alignment 
Range on Protein: 815-906
Range on HMM: 87-170/182.0
YIAWPDHGVPDdSSDFLDFVCHVrnKRAGKEEPVVVHCSAGIGRTGVLITmetamCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCE
 ..|.|.||.      || |  |  . | .|. | ||| || |||||||.     | .  .. . . . ....|..|.  ||| .| ..| |
nfgwkDygvas.leriLdivkvv..afalqegkvavhChaGlGrtGvlia.....cylvyakrltaekaiklvrskrpksiqtreqvelvke
0048567 (Phosphotyrosine protein) phosphatases II 819-864 5.6e-06 20.8 In-house 46-96 (157) alignment 
Range on Protein: 819-864
Range on HMM: 46-96/157.0
PDHGvPDDSSDFLDFVCHVRNKR---AGKEEPVVVHCSAGI---GRTGVLIT
 |.| | . . . .|.... ..      .. ...|||.||    |||..|| 
fdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLig
DSPc Dual specificity phosphatase, catalytic domain 824-864 7.5e-06 20.8 Pfam-A 52-92 (133) alignment 
Range on Protein: 824-864
Range on HMM: 52-92/133.0
PDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLIT
 .. |..|. .  . .| . |.. |.||| ||| |.. ||.
etkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii
DSPc Dual specificity phosphatase, catalytic domain 824-864 7.5e-06 20.8 In-house 52-92 (133) alignment 
Range on Protein: 824-864
Range on HMM: 52-92/133.0
PDDSSDFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLIT
 .. |..|. .  . .| . |.. |.||| ||| |.. ||.
etkiskeleeavefiekaeqkgkkvlVHCqaGisRSatlii
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 829-911 1.1e-10 35.8 In-house 246-343 (350) alignment 
Range on Protein: 829-911
Range on HMM: 246-343/350.0
DFLDFVCHVRNKRAGKEEPVVVHCSAGIGRTGVLITMETAMC---LIE-C-------NQPVYPL----DIVRTMRDQRAMMIQTPSQYRFVCEAILKV
|..|  .        . .|..||||||.||||.|.|..  .     .|         ...         ||  .| ||  |.|.  |. |. ||.|  
dliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy
subfamily_PTEN_pd Subfamily PTEN 841-904 2.7e-08 29.0 In-house 110-172 (184) alignment 
Range on Protein: 841-904
Range on HMM: 110-172/184.0
RAGKEEPVVVHCSAGIGRTGVLITMeTAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFV
 . |.. ||||| || |||||||.    .    ....   |..  ..| . .  .. ||| |.|
eedkknvvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYv
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 844-910 5.7e-13 43.4 In-house 227-293 (297) alignment 
Range on Protein: 844-910
Range on HMM: 227-293/297.0
KEEPVVVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
.. ...||||||.||.||..  .. .  .  ..      |.. .|.|||...||  |. .. .|.||
rnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_CG42327_pd Subfamily CG42327 844-907 1.1e-11 39.0 In-house 246-310 (319) alignment 
Range on Protein: 844-907
Range on HMM: 246-310/319.0
KEEPVVVHCSAGIGRTGVLITMETAMCLIECN-QPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEA
.  |.||||| |.||||..|. . |.  .| . . |   ..|  .| .||  ..|  || |.   
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 849-910 7.2e-10 33.1 In-house 2-63 (69) alignment 
Range on Protein: 849-910
Range on HMM: 2-63/69.0
VVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
|||||.| |||| .|..   |  |  .. |  .. |. ||  | ||.    .| |. .|. .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 849-910 1.4e-09 32.1 In-house 1-62 (69) alignment 
Range on Protein: 849-910
Range on HMM: 1-62/69.0
VVHCSAGIGRTGVLITMETAMCLIECNQPVYPLDIVRTMRDQRAMMIQTPSQYRFVCEAILK
|||||.| |||| .|..   |  |  .. |  .. |. ||  | ||.    .| |. .|. .
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve