Gene PTPN5 in Homo sapiens

Synonym: PTPSTEP, STEP, PTPN5

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN5_RR
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP082_AA protein Get Run
HsapP082_AA_282-555 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0039614 (Phosphotyrosine protein) phosphatases II 269-557 1.8e-87 288.8 In-house 3-290 (297) alignment 
Range on Protein: 269-557
Range on HMM: 3-290/297.0
PREESAREYLLSASRVLQAEELHEKALDPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGGEEKV
|..... |. .   .|| .  |.|||... ||..||.|.. ...| ...  |  . ||||| |||..||||.|...|  |. |.||||.|. ||    . 
plrdallesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrk

YIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRA
.||||||  .||.|||||||......|||.|. .|.. || .|||||.  |... .|. ||.| ..| .| .... . |.| ..|...|.||| ..|. .
fIatqgPlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppsl

PPLLHLVREVEEAAQQEgPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEK
  ||.....|.|| ..  |   |..||||||.||||.|||  ....||. || ||.|.. ..||. |.|..|| .||.|.....  . |
ellleflelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
0050432 (Phosphotyrosine protein) phosphatases II 282-557 2e-86 285.4 In-house 26-300 (308) alignment 
Range on Protein: 282-557
Range on HMM: 26-300/308.0
SRVLQAEELHEKALDPFLLQAEFFEIPMNFVDPK--EYDIPGLVRKNRYKTILPNPHSRVCLtspdpdDPLSSYINANYIRGYG-GEEKVYIATQGPIVS
 .||.  .|.|||||. ||..||.|.........   .  |  . ||||| |||. ||||.|      |. |.||||.|..||  . .. .||||||  .
lsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl......degsdYInAsyvdgyssklprkfIatqgPlpn

TVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWPE----EQVAYDGVEITVQKVIHTEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPL
||.|||||||......|||.|...|.. ||| .|||.    . . |... .|. .. . .|| .| . |.   . |.| ..|...|.|||...|. . .|
tvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeil

LHLVREVEEAAQQegphcAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEK
|.....|..  ..      ||.||||||.||||.|||  ....||..|| ||.... ..||. | ||.|| |||.|.....  | |
ldflelvrkslpg.....gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0047943 (Phosphotyrosine protein) phosphatases II 290-555 5.3e-80 264.1 In-house 4-271 (273) alignment 
Range on Protein: 290-555
Range on HMM: 4-271/273.0
LHEKALDPFLLQAEFFEIPMNFVDP--KEYDIPGLVRKNRYKTILPNPHSRVCLtspdpDDPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMV
| ||.|.. ||..|| ... ....   . .  |    ||||| |||. ||||.|     .|. |.||||.|..||  . | .||||||  .||.||||||
llekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyvdgynlkrk.fiatqgPlpntvedfwrmv

WQEHTPIIVMITNIEEM-NEKCTEYWPEE----QVAYDGVEITVQKVIHTEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEE
|......|||.|...|. .|||  |||.|     . |. . .|. .. . .|| .| . |..    |.|  .|...|.|||...|.   .||.....|..
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrk

AAQQEGPHcAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
| ..   .  |..||||||.||||.|||  ....||. || ||.|.. ..||. | ||.|| |||.|.....  |
alealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0036941 (Phosphotyrosine protein) phosphatases II 292-556 1.6e-79 262.6 In-house 7-277 (297) alignment 
Range on Protein: 292-556
Range on HMM: 7-277/297.0
EKALDPFLLQAEFFEIPMNFVDPK--EYDIPGLVRKNRYKTILPNPHSRVCLtspdpDDPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQ
||.|.. ||. || |.. ......   .  |. . ||||| |||..|.||.|     ||. |.||||.|. ||. . | .||||||  .||.|||||||.
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl.....ddegsdYinAsyvdgydlkrk.fIatqgPlpntvedFWrmvwe

EHTPIIVMITNIEEMNE-KCTEYWP---EEQVAYDGVEITVQKVIH--TEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEA
.....|||.|. .|..  || .|||   .| . |... .|...| .   .|| || . ..   . |.| ..|...|.||| ..|. . .||.....|...
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

AQQEGPHcAPIIVHCSAGIGRTGCFIATSICCQQLR---QEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYE
 ..  ..  |..||||||.||.|.|||  ...|||.    || ||||.. ..||. | |..|| |||.|.....  . 
lkllpsg.gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0051299 (Phosphotyrosine protein) phosphatases II 294-555 6.3e-83 273.8 In-house 19-285 (288) alignment 
Range on Protein: 294-555
Range on HMM: 19-285/288.0
ALDPFLLQAEFFEIPMNFVDP--KEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPdDPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEH
| .. .|..|| |.. ...|.  . .  |  . ||||. |||. ||||.|...|. .. |.||||.||.||  . | .||||||  .||.|||||||...
angltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyidgynlkrk.fIatqgPlpntvedFWrmvweqn

TPIIVMITNIEEMN-EKCTEYWP-EEQVAYDGVEITVQKVIHTEDYRLRLISLK------SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQ
...|||.|...|.. |||  ||| .. . |. . .|  .. . .|| .| . ..       . |.|  .|...|.|||. .|| . .||...|.| .| .
vrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkala

qegPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
   ..  |..||||||.||||.|||  ....||..||.||.|.. ..||. | ||.|| |||.||....  |
...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0040438 (Phosphotyrosine protein) phosphatases II 294-556 2.3e-79 262.2 In-house 14-276 (317) alignment 
Range on Protein: 294-556
Range on HMM: 14-276/317.0
ALDPFLLQAEFFEIPMNFVDP-KEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPdDPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHT
..|  .|. ||.... ...|. ...  |    ||||. |||..||||.|..... |. |.||||.|. |.    | .||||||  .||.|||||||....
ksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyvdgpnlkrk.fIatqgPlpntvedFwrmvweqgv

PIIVMITNIEEMN-EKCTEYWP-EEQVAYDGVEITVQKVIHTEDYRLRLISLK--SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqegPH
 .|||.|. ||.. ||| .||| .| . |... .|...... ... || . ..   . |.| ..|...|.|||...|.   .||.....|.|| .   ..
tvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale...dp

CAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYE
  |..||||||.||||.|||  ....||..|| ||. .. ..||. |.|..|| |||.|.. ..  | 
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0043336 (Phosphotyrosine protein) phosphatases II 296-555 1.2e-75 249.8 In-house 18-276 (278) alignment 
Range on Protein: 296-555
Range on HMM: 18-276/278.0
DPFLLQAEFFEIPMNFVDPKEY-DIPGLVRKNRYKTILPNPHSRVCLTSPdPDDPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHTPI
.. ||..||.|.. ...|....   |  . ||||| |||..||||.|..  . |. |.||||.|. ||   .| .||||||  .||.|||||||......
lktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsll.ggdldsdYinAsyvdgynvprk.fiatqgPlpetvedFwrmvwelgvtt

IVMITNIEEMN-EKCTEYWPEEQVAYDGVEITVQKVIHTEDYRLRLISLK--SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqegPHCAP
|||.|. .|.. .|| .|||.. . |... .|..|..| .|| .| . ..     |.|   ||....|||...|.   .||.....| || .   .   |
ivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavreale...dsngp

IIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
..||||||.||||.|||  ....||. || ||.... ..||. |.|..|| .||.|.....  |
vlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
0045098 (Phosphotyrosine protein) phosphatases II 296-557 7.8e-73 240.5 In-house 7-273 (278) alignment 
Range on Protein: 296-557
Range on HMM: 7-273/278.0
DPFLLQAEFFEIPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCltspdpddplsSYINANYIRGYggeEKVYIATQGPIVSTVADFWRMVWQEHTPII
 ..||. ||. .. .. .  ..  .| . ||||| |||..||||.            ||||.||.||    | .||||||  |||||||||.|......|
ldlllefefllllgipseitpalylgnldknRykdilpydhsrVk...........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvi

VMITNIEEM-NEKCTEYWPEEQ-VAYDGVEITVQKVIHTEDYRLRLISLK------SGTEERGLKHYWFTSWPDQKTPDRA--PPLLHLVREVEEAAQQ-
||.|. .|. .||| .||||.. . |.....|.... ...|| || . .       .. |.||..|.....|||  .|.     ..|.|.....|| .. 
vmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkll

---------EGPHCAPIIVHCSAGIGRTGCFIATSICCQQLrqEGVVDILKTTCQLRQDRGG-MIQTCEQYQFVHHVMSLYEK
           ..  |..||||||.||||...|  .....|  ||.||.|.. ..||. |.| ..|. |||.|..... .. .
aslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 298-559 3.4e-129 424.8 In-house 5-271 (274) alignment 
Range on Protein: 298-559
Range on HMM: 5-271/274.0
FLLQAEFFEIPMNFvDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVM
  |..||.|.|.|| |..|.|..|  .||||||||||..|||.|.| ...|..|||||||||.||..|.|.|.|||||...||||||||..||....|||
kdlekeflelPlnf.dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivm

ITNIEEMNE-KCTEYWPEEQVA-----YDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAP
.|...|.|| ||..|.|... .     |..|||.|.|.....||..| ..||. ..|| .||||.|.|||.|.||.| .||.||.||||....|  ..||
ltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkylerersvkhywytdWPdhksPddantlldlvleveesreeenaklap

IIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQL
..|||||||||||||||.||...|||.|.|||.||..|.||.|||||.||.|||...|....||.|.|
vvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 298-550 7.1e-46 151.3 In-house 20-230 (392) alignment 
Range on Protein: 298-550
Range on HMM: 20-230/392.0
FLLQAEFFEIPMNFVDPKEYD-IPGLVRKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIV
 |.  ||...|   . |.     .  ..||||| |||   .|| |   | | | | |.|| ||...   || |||.||| .... ||||||.||..  |.
alffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvklevid.dipdsdylnasyipsfd.nekayiasqgpnaaslddfwrmvfqenvttia

MITNIEEMNekcteywpeeqvaydgveitvqkvihtedyrlrlislkSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEeaaQQEGPHCAPIIVHC
|.|...| .                                       | . |    . || |||.  | ..  ||....||.    . | .  |.|.||
mvtklkegd......................................kgddartvaqfhftewPdkdvpkhtssllkfikevk...adfGqythpliihc

SAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHH
|||.||||  |.      . ..  .||...   ..|. |  |.|| ||| |.. 
sagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiyg
0045450 (Phosphotyrosine protein) phosphatases II 299-555 1.3e-76 253.6 In-house 28-303 (307) alignment 
Range on Protein: 299-555
Range on HMM: 28-303/307.0
LLQAEFFEIPMNFV----DPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYI--------RGYGGeEKVYIATQGPIVSTVADFWRM
.|..|| ...   |    . ...  |    ||||| |||..|.||.|.|.|.... |.||||.|.         ||    . .||||||  .||.|||||
gllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl.krkfIatqgPlpetvedFwrm

VWQEHTPIIVMITNIEEMN-EKCTEYWPEE--QVAYDGVEITVQKVIHTEDYRLRLISLK---SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEE
.|.... .|||.|. .|.. ||| .|||.|  .. |. . .|. .. | ..| .| . ..      |.| ..|...|.|||...|.   .||....||..
lweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrk

AAQQEgPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGV---VDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
| ..  |   |..||||||.||||.|||  ....||..||.   ||.|.. ..||. |.|..|. |||.|.....  .
aleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallel
0046845 (Phosphotyrosine protein) phosphatases II 300-557 1.6e-84 279.0 In-house 2-275 (284) alignment 
Range on Protein: 300-557
Range on HMM: 2-275/284.0
LQAEFFEIPMNFV----DPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYG----GEEKVYIATQGPIVSTVADFWRMVWQEH
|..|| |.....|    . . .  |  . ||||| |||. ||||.|.|.|.|.. |.||||.|..||.      .| .||||||  .||.|||||||...
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TPIIVMITNIEEMN-EKCTEYWP--EEQVAYDGVEITVQKVIHTEDYRLRLISLKS---GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQe
...|||.|...|.. |||  |||  .| . |... .|. .. . .|| .| ..|.    . |.| ..|...|||||...|. . .||...|.|.|. .. 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen.

GPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEG---VVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEK
 |   ||.||||||.||||.|||  ....||..||   .||.|.. ..||. | ||.|| |||.||....  | |
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
subfamily_CG42327_pd Subfamily CG42327 303-481 5.9e-31 102.3 In-house 10-193 (319) alignment 
Range on Protein: 303-481
Range on HMM: 10-193/319.0
EFFEIPmNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSpDPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIE
|| ..| ...   .   ..   |.|.  ..| |..|| | .  .||. . |..|.|.|||   .  |||.| .  .. .||||.||.  . .|| .|.. 
efrdlP.qliaradevPvtskdksrvinvvPlPetrvvlqr.igdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdls

EMN-EKCTEYWPEE-----QVAYDGVEITVQKVIHTEDYRLRLISLKS--GTEERGLKHYWFtSWPDQKTPDRAPPLLHLVREVEEA
|   ..|.||.| .     . .|  . .|...    . | .  . ||   . | | | |||.  |.. . |    .|. .. ||...
elGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrss
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 307-552 4.4e-42 138.7 In-house 41-279 (290) alignment 
Range on Protein: 307-552
Range on HMM: 41-279/290.0
IPMNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDplssYINANYIRGYggeEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMN
.| .... | .|    ..||||| .  |  .|| |    . |    |. |||..|    . ..| |||.. .|| |.|||| ||..  |||. . ||. .
lpvqylerkifdkntefkknrykdvvcndktrvilkdGydGd....yvhanyvkGl...kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGk

EKCTEYWPEEQV-AYDGVEITVQKVIHT-ED--YRLRLI---SLKSGTeERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAqqeGphcaPIIVHCSA
 || .|.||..  .    ||||    .. .|    ....     .||  |  |||.   ||||.  .  .  || ..| . .|.   |    |..|||||
akceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGk.ehklkhlkikswpdksvalstlallrtlrilrkas...G....pvvvhcsa

GIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
|||||| |.|  .. | | .   .|.|..   ||. | . .|   ||  . ...
GiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveil
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 309-552 5.9e-61 201.5 In-house 48-287 (319) alignment 
Range on Protein: 309-552
Range on HMM: 48-287/319.0
MNFVDPKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDpLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHTPIIVMITnieemNEKC
.|  | .  ...    |||.  ||.  ...| |   .  .  | |||| .. ||  ..| |||.|||   |.||||||.|. ..  ||..|     ..||
vnladqtfanldqnkdknriinilafdknvvklerliGee.fsdyinasfvtGyqrkdk.yiaaqGPldntladfWrmiweyncstivllt.....kdkc

TEYWPEEQV-AYDGVEITVQKVIHTEDYRLRLISLKS---GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgPHCAPIIVHCSAGIGRTG
..||| . |  ..  .. |. |  |..| .| | |      .. | .. . |  |||.  || . .|. ||. |.   ..|  | |.|.||||||.||||
sqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltske.nhranivvhcsaGvGrtG

CFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
 .|.  .  .....|  ||. ..  .|||.|  ..|   ||.|..  .
vyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
DSPc_SM00195 314-555 9.6e-80 263.0 In-house 18-261 (263) alignment 
Range on Protein: 314-555
Range on HMM: 18-261/263.0
PKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDdPLSSYINANYIRGYgGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEE-MNEKCTEYW
 .| ...  ..||||| |||. |.|| |.... . . |.|||||||.|.  ..| |||||||  |||.|||||||.|...||||.|. ||  .|||..||
tteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PEE---QVAYDGVEITVQKVIHTE-DYRLRLISLKSGT--EERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgphCAPIIVHCSAGIGRTGCF
|||   .  .. .......|.... .. || ..|.  .  |.| ...|....|||...|| . ..|.|.|.|..  ...    .||.||||||.||||.|
peesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtf

IATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
....|....|..|  ||| .. ..||. | ||.|| |||.|.....  |
vtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 314-555 9.6e-80 263.0 In-house 18-261 (263) alignment 
Range on Protein: 314-555
Range on HMM: 18-261/263.0
PKEYDIPGLVRKNRYKTILPNPHSRVCLTSPDPDdPLSSYINANYIRGYgGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEE-MNEKCTEYW
 .| ...  ..||||| |||. |.|| |.... . . |.|||||||.|.  ..| |||||||  |||.|||||||.|...||||.|. ||  .|||..||
tteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivmlteeeengkekcdryw

PEE---QVAYDGVEITVQKVIHTE-DYRLRLISLKSGT--EERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgphCAPIIVHCSAGIGRTGCF
|||   .  .. .......|.... .. || ..|.  .  |.| ...|....|||...|| . ..|.|.|.|..  ...    .||.||||||.||||.|
peesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts...sgpivVhCsaGvgRtgtf

IATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
....|....|..|  ||| .. ..||. | ||.|| |||.|.....  |
vtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 316-559 9.2e-74 242.8 In-house 11-267 (270) alignment 
Range on Protein: 316-559
Range on HMM: 11-267/270.0
EYDIPGLVRK---NRYKTILPNPHSRVCLtSPDPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEY
| |.|  .|.   |||. |||.|..||.| ..  .|. . ||||||.||. ||.| |||..||  .|. .||||.|.|... |||.|..|| . .||  |
esdlpeaargkklnRyadiLPsPatRvrl.eeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPEEQVA---YD--GVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAP------PLLHLVREVEEAAQQEGPHCaPIIVHCSAGI
||.|.     .    .......  ..| |.|. . |..  ||| | |.|...|||.  | ..        ||...|.| .  ..      |..||||||.
WpaepkekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGv

GRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQL
||||..||. |... | ... ||.|.   .||.||  ..|. |||.|.......| ...
gRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerr
0049772 (Phosphotyrosine protein) phosphatases II 316-557 2.1e-40 134.8 In-house 40-281 (314) alignment 
Range on Protein: 316-557
Range on HMM: 40-281/314.0
EYDIPGLVRKNRYKTILPNPhSRVCLTSPDPDDplSSYINANYIRGYggeeKVYIATQGPIVSTVADF----------WRMV--WQEHTPIIVM------
 .|..    ||||. ||| . .||.| . . ..  |.||||.|..|.    . .||||||   || ||          ||||  .. .. .|||      
vadlflnrdknryldilpad.nrvilpglpvsg..sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------ITNIEEM-NEKCTEYWPEEQvaydgveitvqkvihtedyrlRL------IslksgtEERGLKHYWFtSWPDqKTPDRAPPLLHLV
               .... .  || . ..... .                     .              |..|.|....  .||  ...    .....
adelsrLdaAlgKtpllildgngneptaadlellk.....................eelydpelf......erlgikylri.pvpD.gsaplledfdefl

REVEEAaqqegPHCAPIIVHCSAGIGRTGCFIATSICCQQLrqeGVvDILKTTCQLRQDRG-----GMIQTCEQYQFVHHVMSLYEK
. .|||     .   |..|||.||.||||.|... ... .|   || .. ..  ..|. |      |.|.. |||.|.....  | |
efieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 317-552 2.7e-60 199.3 In-house 20-251 (284) alignment 
Range on Protein: 317-552
Range on HMM: 20-251/284.0
YDIPGLVRKNRYKTILPNPHSRVCLTSPDPDDpLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHTPIIVMITnieemNEKCTEYWPEEQ
 ...    |||.  ||.  ...| |   .  .  | |||| .| ||  ..| |||||||   |.||||||.|. ..  ||..|     ..||..||| . 
anldqnkdknrighilafdknvvklerliGee.fsdyinasfitGyqrkdk.yiatqGPldntladfWrmiweyncstivllt.....kdkcsqywplki

V-AYDGVEITVQKVIHTEDYRLRLISLKS---GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgPHCAPIIVHCSAGIGRTGCFIATSIC
|  ..  .. |. |  .|.| .| | |      .. | .. . |  |||.  || . .|. ||. |.   ..|  | |.|.||||||.|||| .|.  . 
vikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltske.nhranivvhcsagvgrtgvyivldvl

CQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
 .....|  ||. ..  .|||.|  ..|   ||.|..  .
ldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 319-555 9.7e-69 226.9 In-house 45-282 (319) alignment 
Range on Protein: 319-555
Range on HMM: 45-282/319.0
IPGLVRKNRYKTILPNPHSRVCLTSPdPDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWPEEQ-
 .   .||||. ||.  ..|| |..  .. . | ||||..| ||  |.. .||||.|.  |. |||||||.|.. |.||.|.. |  . |. .|||||. 
keenkkknryqnilaydrtrvvlsel.dgvegsdyinasfidgyq.erekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenf

VAYDGVEITVQKVIHTEDYRLRLISLKSGT---EERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQegPHCAPIIVHCSAGIGRTGCFIATSICC
. |  . .|...  ..|||  | ..|.  .   | | .||. .|.|||.. |..|  ||.|....... ..  ..  ||.||||||.|||| ||. ..  
eeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksrek..tqsgPivvhCsaGvGRtGtfivldaml

QQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
.....|||.|. .|  .||  |  |.|. |||.|.....  .
ervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyeallea
subfamily_PTPN9_pd Subfamily PTPN9 319-556 1.1e-65 216.6 In-house 39-290 (297) alignment 
Range on Protein: 319-556
Range on HMM: 39-290/297.0
IPGLVRKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWP-EEQ
... ..||||. .|   ..|| |.. | .|. | |||||.. ||  ..| .||||||.  || |||||||.... .|||.| ..|.   ||..||| ||.
lranleknrytdvlcydetrvvlakvd.edeasdyinanfvdGyk.qkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleee

VAYDGVEITVQKV--IHTEDYRLRLISLK--SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAA----------QQEGPHCAPIIVHCSAGIGR
 . . ....|..|   ..|||. | . .|     |.| . |. |.||||  .|. |  ||.....| |.           ..  |.  ||.|||||||||
ssaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGr

TGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYE
|| ||.  || ..|...|.||. .|  .||. |  .||| |||.| .  .  | 
tGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_PTPN14_pd Subfamily PTPN14 319-555 6e-50 164.9 In-house 46-295 (300) alignment 
Range on Protein: 319-555
Range on HMM: 46-295/300.0
IPGLVRKNRYKTILPNPHSRVCLTSPDPDdpLSSYINANYIRG-YGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPEE-
 |  ..|||.| .||  ..|| |..   .   . ||||  |.   ||.|. ||..|||.  || |||.|||.... .|||.|.. |. .||. .|.|.. 
lpenaeknrfkdvlPyednrvelsptken..stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkle

----QVAYDGVEITVQKVIHTEDYRLRLISLK--SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHC------APIIVHCSAGIGRT
    .| ..  ..| . . ... .  . . ||     ||| . |  .| |||.. |.   . |. ..||.   ..   .        |..||||||.|||
skkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrt

GCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
|  | . .  . | .. ..|| |.  .||. |  ..||  ||.||..|.  |
GvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 320-554 2.5e-58 192.8 In-house 46-286 (325) alignment 
Range on Protein: 320-554
Range on HMM: 46-286/325.0
PGLVRKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGGeEKVYIATQGPIVSTVADFWRMV--WQehTPIIVMITNIEEMNEKCTEYWPEE--
|  . |||.| ...  .|||.| . . ||| | ||||.|.| . .  .|..|.| |  .|. |.||.|  |.  ....|..  ... ...|. |||.|  
penkaknrfknvvaldksrvvletkk.ddpssdyinasylrddkk.kdvflaaqaPltatindlWrlvldWr..csvvvvlneldlgkdrcavywpkemg

-QVAYDGVEITVQKVIHTEDYRLRLISLKS--GTEERGLKHYWFTSWP---DQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIAT
  . . |.|. .. . .  ||  | . .|   . | | .| . . ||.    || |    ..|.|| .|.|  . .    .||.||||||.|||| ||. 
ksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfisl

SICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSL
    ... .|  |||..   .||.||  |..| .|| .... .  
ysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealve
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 320-551 1.2e-37 124.4 In-house 31-290 (297) alignment 
Range on Protein: 320-551
Range on HMM: 31-290/297.0
PGLVRKNRYKTILPNPHSRVCLTSPDPDdplSSYINANYIRGYGGEEK-VYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEE-MNEKCTEYWPEE-Q
.. .|||||. ||    .|| |    ..   . ||||.|.     |..  || .|||. .|| |||..|...   .|||.....|   .||. |||.  |
nsslrknryrdilatddtrvkllrvite...rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvvq

VAYDGVEITVQKVIHTED-Y-R--LRLISLKSGTEERGLKHYWFTSWPDQKTP------DRA-----------PPLLHLVR-------EVEEAAQQEGPH
      .. |. . .| | . |  |  . |   .|.| ..|  | ||||   |      .|            | .| ||           |. . | | 
erlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamvflqleslraempr

CAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHV
 |...||||||.||.|  . . .  ..||.. . |.     .||. |  ..|| ||.......
nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellyda
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 320-552 1.4e-35 117.3 In-house 35-265 (281) alignment 
Range on Protein: 320-552
Range on HMM: 35-265/281.0
PGLVRKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWPEEQ--
|   .||||  |     ||| |    |.   . || |||||     .. || ||||   | ||||||.||| |  |||. .. | | |||.||.| .   
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprnahc

-VAYDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEaaqqegpHCAPIIVHCSAGIGRTGCFIATSICCQQ
 . .| . .. .     .      . |    | | . |. .  ||| . |. .  .|...|..         . .| ..|||||.||.| ..|  |. | 
clqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira.......rstppvihcsagvgrsgtlmaveialqs

LRQE-GVVDILKTTCQLRQ-DRGGMIQTCEQYQFVHHVM
..    . || .   .||   |   .|| .|| .. .|.
ihshftlpdikqivshlrvtgraasvqtlqqymliwkvl
subfamily_PTPRN_pd Subfamily PTPRN 321-551 1.4e-49 163.4 In-house 55-287 (297) alignment 
Range on Protein: 321-551
Range on HMM: 55-287/297.0
GLVRKNRYKTILPNPHSRVCLTSPDPdDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEE-MNEKCTEYWPEEQV-A
  |.|||.|..||  |||| |..    .  | ||||  |      . .|||||||. |||||||.|||.. . .||..|..||   ..|..|||.|    
knvkknrskavlpydhsrvklkeeas.aeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsev

YDGVEIT-VQKVIHTEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqeGpHCAPIIVHCSAGIGRTGCFIATSICCQQ
|.  |.  | . | ..|| .| . ||    .| | .  . | |||.. .|  | .||.. | |. . .  |  ..||.||||.| ||||..|.  . ...
yhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr..G.rscpivvhcsdGaGrtGvyilidlvlnr

LRQ-EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHV
| .    .||  |   ||..| |...| .|..|.  .
llkGvkeidiaatlehlrdqrpglvktkdqfefalta
0040439 (Phosphotyrosine protein) phosphatases II 322-555 2.7e-69 228.8 In-house 11-245 (249) alignment 
Range on Protein: 322-555
Range on HMM: 11-245/249.0
LVRKNRYKTILPNPHSRVCLTsPDPDDPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWP-EEQVAY
 . ||||. |||..||||.|. . |. .||.||||.|| ||    . .||||||  .||.|||||.|...  .|||.|. .|. .||| .||| .. . |
nkdknrypdilpydhsrvkls.ilpglflsdyinAsyidgyyikrr.fiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsley

DGVEITVQKVIHTEDYRLRLISLK--SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgPHCAPIIVHCSAGIGRTGCFIATSICCQQLR
... .|. .|.. .|| .| . |.     |.|  .|...|.|||...|.  ..|| ....|..| ..  |   |..||||||.||||.|||  ....||.
gdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmleqle

QEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
 |. ||.. . ..||. |.|..|. |||.|.. ..  .
kelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 322-552 8.2e-59 194.0 In-house 44-273 (315) alignment 
Range on Protein: 322-552
Range on HMM: 44-273/315.0
LVRKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWPE---EQV
  .||||| |||  ..|| |   | |.| | |||| ||...  ..| |||.|||  ..| ||||||.||..  |||.|. .| .  ||  |||.   . |
nfkknryknilPldsarvklevid.dsPdsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsv

AYDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAaqqEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLR
 .  ..... ..  . |   | . .. . | | .  . || |||. .. ..  ||.|..||      .|..  ...||||||.|||| .|.   . .|..
efGsikvellsleadtdgvarklvtrkseesrtvtqfqftewPdkGvdkqtssllklikevkad...ngkkefsllvhcsaGvGrtGvvisidevvaqik

QEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
.. .||....  .||..|  ..|| |.| |.. ..
rtrsvdvfnfvknlrakrpylvqteeeyafiydav
subfamily_PTPN3_pd Subfamily PTPN3 322-557 7.9e-56 184.0 In-house 41-277 (280) alignment 
Range on Protein: 322-557
Range on HMM: 41-277/280.0
LVRKNRYKTILPNPHSRVCLTSPDPDdplssYINANYIR-GYGGEEKV--YIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPE--E
 . ||||. |||  . || |.. . |     ||||||.     ... |  |||||||. .|..|||.|||.... .|||.|. .|.   || .||||  .
nlsknryrdilpydatrvklkesetd.....yinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkChqyWPeted

QVAYDGVEITVQKVIHTEDYRLRLISLKSGT--EERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQegpHCAPIIVHCSAGIGRTGCFIATSICC
.. | . .....|  .|. | || . ||  .  ||| . .  ...|||.. || .  .|..|..|... .    .  |..||||||||||| .|.  .. 
eleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsg...keePvvvhCsaGigrtGvlilletal

QQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVH-HVMSLYEK
. . ..  | .|.   ..|. |. ..|| .||.||   .. .||.
alieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_PTPRD_pd Subfamily PTPRD 323-552 2.1e-88 292.4 In-house 49-277 (564) alignment 
Range on Protein: 323-552
Range on HMM: 49-277/564.0
VRKNRYKTILPNPHSRVCLTSPDPDdPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWPEE-QVAYD
 .||||. |..  ||||.|.. . | . | ||||..| ||  ..| |||||||. .|..|||||||.... .|||.|..||... || .||||. .  |.
kaKNRyanivaYdhsRVvLskvegd.egsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetyg

GVEITVQKVIHTEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqegPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQ
....|...  . .|| .| ..||     | |  ... ||||||.  |. | .||.|.|.|.....   |.  ||.||||||.||||.||. ... .....
eltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralne...pdagPivVhCSaGVGRTGtfividamlerike

EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
|..||| ..  .||..|  |.|| |||.|.|...
ektvDiyqyvkalrkqRnamVqteeQYiFiheai
subfamily_PTPN6_pd Subfamily PTPN6 323-558 3.1e-71 234.9 In-house 55-299 (306) alignment 
Range on Protein: 323-558
Range on HMM: 55-299/306.0
VRKNRYKTILPNPHSRVCLTspDPDDPLSSYINANYIR-GYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWPEEQVAYD
 .|||||.|||  |.|| |.  .|. | | |||||||.    |..| |||||| . .||.|||||||||.. .|||.|.  |  .|||. |||.|.   .
keknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekee

GVEITVQKVI--HTEDYRLRLISL---KSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEG-PHCAPIIVHCSAGIGRTGCFIATSICCQ
  .|.|..|   ...|| || .|.   |...||| . .| |.||||. .|     .|.....|.. ...    .  ||.||||||||||| || . |  .
yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillk

QLRQEGV---VDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQ
.....|.   .|| |.  ..|. | |..|| .||.||..... | ..
liekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
0042113 (Phosphotyrosine protein) phosphatases II 323-555 3e-69 228.4 In-house 10-242 (245) alignment 
Range on Protein: 323-555
Range on HMM: 10-242/245.0
VRKNRYKTILPNPHSRVCLTsPDPDDPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWP-EEQVAYD
. ||||. |||..|.||.|. ||. |. |.||||.|. ||   .| .||||||  .||.|||||.|...  .|||.|. ||.. .|| .||| .| . |.
kdknrysdilpydhtrvkls.pdggdldsdyinasyvdgyritpk.fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltyg

GVEITVQKVIHTEDYRLRLISLK--SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQegPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQ
.. .|. .. | .|| .| ....     |.|   ||....|||...||    || ....|..| ..  .   |..||||||.||||.|||  ....||. 
dftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfiaaylmleqlek

EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
|. |.. ..  .||. |.|..|| .||.|.....  .
elgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 323-555 3.4e-68 225.0 In-house 47-282 (305) alignment 
Range on Protein: 323-555
Range on HMM: 47-282/305.0
VRKNRYKTILPNPHSRVCLTSPDPDDpLSSYINANYIRGYGGeEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPEEQVA---
..|||.| | . ...|. ||  . .|  | ||||.|. || . .| ||..|||. .|||||||....|..  |||.|.. |. ..||  ||||..     
kaknrlkeitlldddriiltekesld.dsdyinasyvdgykr.kkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekke

YDGVEITVQKVIHTEDYRLRLISLKS---GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgpHCAPIIVHCSAGIGRTGCFIATSICCQQ
.. ......   ...||  | ...       |.| . .| .|.|||.  |. |  ||.|...|... ...  .  |..||||||.|||| ||| .|  ..
fgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkd..kgvpllVhCsagvgRtGvfiavdialer

LRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
|..|.|||. . . |||. | .|.|| .||.|.| .. ..
lkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldel
subfamily_PTPN12_pd Subfamily PTPN12 323-560 4.4e-67 221.0 In-house 41-282 (290) alignment 
Range on Protein: 323-560
Range on HMM: 41-282/290.0
VRKNRYKTILPNPHSRVCLTSPDPDDpLSSYINANYIRGYGGeEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWPEE---QVA
|.||||| |||  .||| |.  . ..  |.|||||.|.|  | .. |||.|||.  |. |||||.|. .. |.||. .. |..  ||  |||||   .. 
vkknrykDilPydksrvelskieeee.gsdYinanfikgveg.kleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeele

YDGVEITVQKV-IHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqegPHCAPIIVHCSAGIGRTGCFIATSICCQQLR
.. .|.|...    ..|. .| . ..   |.| .. . .|.|||. .| .| .||.|...|.|  .    . ||..||||||.||||  ||  .  ..|.
fgefevtleeekavdddflirtLkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelqe...sedaPlvvhCsaGvGrtGtiiaidyvrellk

QEGV---VDILKTTCQLRQDRGGMIQTCEQYQFVHH-VMSLYEKQLS
.| .   .|. .   .||..|  ..|| |||..|.. |..| .|.|.
aekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkele
0037934 (Phosphotyrosine protein) phosphatases II 323-554 1.4e-65 216.6 In-house 11-240 (243) alignment 
Range on Protein: 323-554
Range on HMM: 11-240/243.0
VRKNRYKTILPNPHSRVCLtspdpDDplSSYINANYIRGYGGeekvYIATQGPIVSTVAD----FWRMVWQEHTPIIVMITNIEEM-NEKCTEYWPEEQv
. ||||..|||..||||.|     ..  |.|||||.|.....    .||||||  .||.|    ||||.|.... .|||.|. .|.  ||| .|||.|. 
lsknrysdilpydhsrvkl.....eg..sdyinanliyvtpr....liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgev.

AYDGVEITVQKVIHTEDYRLRLISLKS---GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQ-----EGPHCAPIIVHCSAGIGRTGCFIAT
 |.....|. .. |..|| .| ..|.    . ..|   ||....|||...||   .|| ...|| |  ..       ..  |..||||||.||||..|| 
tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaa

SICCQQLrqeGvVDILKTTCQLRQDRGG-MIQTCEQYQFVHHVMSL
 .....|   | ||.... ..||. |.| ..|| .||.|.....  
ylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_PTPRA_pd Subfamily PTPRA 323-555 7.2e-65 214.0 In-house 59-294 (330) alignment 
Range on Protein: 323-555
Range on HMM: 59-294/330.0
VRKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWPEE-QVAYD
 .|||.  |||. .||| |.  .   . | |||| .| ||  | . .||.|||   || |||||.|. ..  |||.|...|  .|||. |||.|  |.| 
keknrvvnilPydfsrvilsvke.GveesdyinasfidGyk.ekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyG

GVEITVQKVIHTEDYRLRLISLK---SGT---EERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPhcaPIIVHCSAGIGRTGCFIATSICCQ
 . ..|...  ..|| .| . ..    .|   ..| .. . ||||||   |  .  .|.|...|..  ||..    ||.||||||.|||| ||. .   .
nirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag...pivvhcsaGvGrtGtfivldavle

QLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
... |..||. ..  .||. |  |.|| |||.|...|.  |
rvkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 323-552 1e-61 203.6 In-house 50-275 (315) alignment 
Range on Protein: 323-552
Range on HMM: 50-275/315.0
VRKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTE-YWPEEQVAYDG
..||||  |..  .||| |   .  || | |.|||.| ||   .. |||.||| |..| ||||.|..|.   |||.||. | ... .| |||...| |  
kqknryiniiaydksrvqlplle.ndphsdyvnanfidGyn.kkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGk

VEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGphcAPIIVHCSAGIGRTGCFIATSICCQQLRQEGV
. .| ..  . ..|  | .|  .| . | .  . .||||| . |  . ||..|.| |    ...    ..|.||||||.|||| ||. .   .|.  | .
itvtrkseevnteytvrtlsvvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitldavldqaeaena

VDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
.|. .   ..|| | .|.|. |||||.. ..
idvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 323-553 3.4e-61 201.8 In-house 42-273 (281) alignment 
Range on Protein: 323-553
Range on HMM: 42-273/281.0
VRKNRYKTILPNPHSRVCLTsPDPDDPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPEEQ--VAY
| ||||. |    ..|| .| |. ..  . |||||.. || ||.. |||||||. .....||.|||...  .|||.|. ||. . ||  |||...  . |
vlknrYsnivaYDatrvkvt.pneenkntDYinanfvpgykgeke.yiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselky

DGVEITVQKVIHTEDYRLRLISL-KSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPhcAPIIVHCSAGIGRTGCFIATSICCQQL-R
  | .. ..  ... |  | ..| ....|.| ...  .|.|||.  |. .  ||.  .||... ...    ||...|||||.||||..||    .... .
gdvtvkstaeeekatyierkfkleresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk..aplvihCsaGvGrtGtyialDrlvkavea

QEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMS
..  .|.  .  .||..|  |.||  ||.||.... 
eleeldvkavvaelrkernlmvqtvvqyefvykavl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 323-552 3.7e-57 188.6 In-house 44-272 (515) alignment 
Range on Protein: 323-552
Range on HMM: 44-272/515.0
VRKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWPE---EQVA
 .||||| |||   .|| |   . |.| | |.|| ||...   .| |||.|||  ..| ||||.|.||..  |.|.|. .| .  ||..|||.   . | 
fkknryknilPydsvrvklevin.dnPhsdyfnasyipsfd.ndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

YDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGphcAPIIVHCSAGIGRTGCFIATSICCQQLRQ
.  ... .  .    .   | . .  | . | .  . || |||. .| ..  || |..||    .|      |.|.|||||.|||| .|.   .  . ..
fGsikvelvsleactggikrkltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt...hpliihcsaGvGrtGvvisidsvvahakt

EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
  .||....  ..||.|  ..|| ||| |.. ..
trmvdvfnfvtnirqkrpylvqtqeqyafiygav
subfamily_PTPN23_pd Subfamily PTPN23 323-554 9.8e-54 177.1 In-house 44-278 (288) alignment 
Range on Protein: 323-554
Range on HMM: 44-278/288.0
VRKNRYKTILPNPHSRVCLTsPDPDDplssYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEK-CTEYWPEE---QVA
. |||.. |||  |.||.|     ||    |||| ....       .||||.|. ||..|||.||.......|||... ||.... . .||||.    | 
seknrsrdilPyDhnRvklr.gskDD....YinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvk

YDGVEITVQKVIHTEDYRLRLISLKSG--TEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEE-AAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQ
.. ...|...| .|| .  | ..|.     . . ..|  .||||.   |.    ||... |||.   ... .  .|..||||||.|||| |       ..
fgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavre

L-RQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSL
| ...|..||..   .||..|  |.|. ||..|. ...  
lekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavle
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 323-557 1.2e-51 170.3 In-house 39-278 (287) alignment 
Range on Protein: 323-557
Range on HMM: 39-278/287.0
VRKNRYKTILPNPHSRVCLtSPDPDDpLSSYINANYIRGYGGEEkVYIATQGPIVSTVADFWRMVWQEHTPIIVMI-TNIEEMNEKCTEYWPEEQVAY--
|.||||  .||  ..|| | | ...   |.||||||. .|  .|  .||.|||| .|| ||||.|.....  ....  ..||   || .|||| .|    
vkknryadvlPiddtrvll.saegel.Gsdyinanyvasytdde.afiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrv

DGVEITV-QKVIHTEDYRLRLISLK--SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREV--EEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQ
 |  ... .. |   .|  | . |    . | | .| . . ||||.  .  |  |. .| .|     .....    |..||...||||.| ..|| .. .
GGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvs

QLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEK
.| . | ||. ..  .||. | ...|.  |....   .  | |
rledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
subfamily_ptpA1_pd Subfamily ptpA1 323-516 7.5e-36 118.8 In-house 48-256 (418) alignment 
Range on Protein: 323-516
Range on HMM: 48-256/418.0
VRKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGygGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPE----EQV
  ||||  |||  |.|| |   . |   | ||||||| |     | .|.||||.  |.||||||||...  ||||..   |.   ||  ||||    ||.
tsknrytnilpvnhtrvqlkkiq.dkegsdyinanyidg..aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

AY--DGVEI------TVQKVIHTEDY--RLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPH---CAPIIVHCSAGIGRTG
.   .| |.       . .||.  .     | | |    | | . .| .  |||.. ||.. |. .|.. . .  .|  |      |||||||||.||||
siygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtg

CFIATSICCQQL
 | .. |  ..|
tfctavimmkkl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 323-555 6.8e-30 98.7 In-house 56-288 (305) alignment 
Range on Protein: 323-555
Range on HMM: 56-288/305.0
VRKNRYKTILPNPHSRVCLTSPDPddplSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEE-MNEKCTEYWPEEQVAYDG
. ||||. .  . .| | |  | |    | || |||.      || .|..|||.  |. .|| || |..   |||. .  |  . ||..|||  |     
itknryqdvpcqdqsavkldkpsp....sdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

VE--ITVQKVIHT----EDYRLRLISL--K-SGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEeaaqqeGPHcAPIIVHCSAGIGRTGCFIATSIC
.   | |..|  .     |  ...  |    || ..  ..|  .| |||.  |      | |.  .       | .  ||.|||||||||||  .|    
lksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsair......gsk.vpivvhcsagigrtgtivaieyi

CQQLRQEGVV-DILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
 ... ..  .  . .    ||..|   ||.  || |.| ||  |
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 323-427 1.1e-23 78.5 In-house 48-163 (350) alignment 
Range on Protein: 323-427
Range on HMM: 48-163/350.0
VRKNRYKTILPNPHSRVCLT-SPDPDDP------LSSYINANYIRGY----GGEEKV-YIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCT
  ||||| |||  |||| |  |. . |        . ||||||..        . .  |||||.|. ||| ||.... . . ..|...|.  |.| ||| 
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

EYWPEEQvaYDGVEITVQ
.||.| .  ||.. . ..
rYWqegs..ydditvkla
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 323-428 2.5e-16 53.9 In-house 49-167 (349) alignment 
Range on Protein: 323-428
Range on HMM: 49-167/349.0
VRKNRYKTILPNPHSRVCLT-SPDPDD------------PLSSYINANYIRGY-GGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EK
  ||||| |||  |||| |  |. .               |  ||||||..      || ||||| |. ||| ||....  .  .... ... .| . ||
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CTEYWPEeqVAYDGVEITVQK
|  || |   .|..... .| 
cdiywqe..lsysnitvklqn
subfamily_eak_pd Subfamily eak 323-466 3.8e-16 53.4 In-house 53-196 (332) alignment 
Range on Protein: 323-466
Range on HMM: 53-196/332.0
VRKNRYKtILPNPHSRVCLTSPDPDdPlSSYINANYIrGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMI-TNIEEMNEKCTEYWPEEQ---VA
|..| .| |.|. .  | |||   . .   ||||  .  .    . || |  .  . |  ||.|| ....| ||..  ..|.  ||   |.|..    . 
vnrnvvk.ivpydrylvrltssqln.r.lGyinasla.efsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelk

YDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPD
.  .... .. .. . .. ||. |. | |   ..|| .  | . ..| 
fGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 323-552 4.2e-16 53.4 In-house 48-275 (303) alignment 
Range on Protein: 323-552
Range on HMM: 48-275/303.0
VRKNRYKTILPNPHSRVCLTSpdpddplSSYINANYIRGygGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTE-YWPEEQ--VAY
. |||.  ..   ||.| |.        |||| |.|.      .|  | || |.  | ||||.|. ...   ....    |...   .  .|..|  . .
mdknrfvdvicldhskvklsd.......ssyihasylel..dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

DGVEITV---QKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDR-APPLLHLVREVEEAAQQEGPHCaPIIVHCSAGIGRTGCFIATSICCQQ
.   | |   ..|  .. . |...|.  |.    |. . . .|| .. |   .| ... . ...   ..  .   | .    .| ||.| |     .   
eersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdst.ptvymslsgcgragtfalfetahls

LRQE-GVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
| .|   .|..|   ..|. |   .|   |. .|. ..
lhseqasldlvkclenvrngrlhavqnlsqfsvvytll
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 323-418 1.8e-15 51.3 In-house 53-146 (310) alignment 
Range on Protein: 323-418
Range on HMM: 53-146/310.0
VRKNRYKTILPNPHSRVCLTSPDpdDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPEEQVA
. ||||  ..    ||| |.          || |||..      . .| .|||.  |. |||||..|| .  |... .  ||   ||  |||   |.
mhknrysdvvcldtsrvklkidk..sryedyihanyvktny.lrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvt
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 323-405 2.3e-10 34.5 In-house 38-121 (347) alignment 
Range on Protein: 323-405
Range on HMM: 38-121/347.0
VRKNRYKTILPNPHSRVCLTsP-----DPDDPLSSYINANYIRgYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMItnIEEMN
. ||| |    .  .|| |. |      . |.  .|||| .|. .   .| || || |. .|| |||.||   .   .| |  .| ..
lsknrskdvklidatrvvls.peksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti..fepik
Y_phosphatase Protein-tyrosine phosphatase 324-552 6e-77 253.6 Pfam-A 3-233 (235) alignment 
Range on Protein: 324-552
Range on HMM: 3-233/235.0
RKNRYKTILPNPHSRVCL-TSPDPDDplssYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWP---EEQVA
.|||||.|||  ..|| |  |..| |    ||||||..||  |.| .||||||. ||..|||||||||.. .|||.|. ||. .||| .|||   ||.. 
kknRykdilpydktrvklkgsegpsd....YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YDGVEITVQ-KVI-HTEDYRLRLISLKSGTEE---RGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAqqeGPHCAPIIVHCSAGIGRTGCFIATSICC
|. ...... |.  ....| || ..||. .||   | .|....|.|||...|. . .||.|.|.||.      .. .|..||||||.||||.|.| .|..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldill

QQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
.||..|. ||.|.. ..||. | ||.|..|||.|.....
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
Y_phosphatase Protein-tyrosine phosphatase 324-552 6e-77 253.6 In-house 3-233 (235) alignment 
Range on Protein: 324-552
Range on HMM: 3-233/235.0
RKNRYKTILPNPHSRVCL-TSPDPDDplssYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWP---EEQVA
.|||||.|||  ..|| |  |..| |    ||||||..||  |.| .||||||. ||..|||||||||.. .|||.|. ||. .||| .|||   ||.. 
kknRykdilpydktrvklkgsegpsd....YInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YDGVEITVQ-KVI-HTEDYRLRLISLKSGTEE---RGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAqqeGPHCAPIIVHCSAGIGRTGCFIATSICC
|. ...... |.  ....| || ..||. .||   | .|....|.|||...|. . .||.|.|.||.      .. .|..||||||.||||.|.| .|..
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldill

QQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
.||..|. ||.|.. ..||. | ||.|..|||.|.....
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykai
subfamily_PTPRB_pd Subfamily PTPRB 324-556 2.9e-76 251.3 In-house 53-286 (293) alignment 
Range on Protein: 324-556
Range on HMM: 53-286/293.0
RKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGGeEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPEE--QVAYD
 ||||. |||  |||| |.. . |.. | |||||||.||   .. .||||||. .|| |||||||.... ||||.|.. |.  .|| ||||..  .|.| 
aknrytnilpydhsrvkLaalk.desgsDYinanyipgyns.prefiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyG

GVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEG
 ...|...  ..||. .| .... ..||| ...| ||||||   |... .||..||.|.||.. .  . .||.||||||.|||| |||     |....| 
dikvtlvaeeeledwvirelkiekekeerkvrqyhftsWpdhgvPektktlldfvrtvreaie.ktaskrPivvhCsaGvGRtGtfialdrllqaieeed

VVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM-SLYE
.|||. . ..||..|  ..|| .|| |.|... .| .
yvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 324-553 4.7e-76 250.9 In-house 48-277 (318) alignment 
Range on Protein: 324-553
Range on HMM: 48-277/318.0
RKNRYKTILPNPHSRVCLTsPDPDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWPEEQ-VAYDG
.||||  ||.  |.|| |. .  ... | ||||||| ||  ..| |||.|.|.  |. |||||||. .. .|||.|..||   .|.  |||...  .|. 
aknryanilaydhtrvkLq.mlegeegsDyinanyidGyr.rkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygk

VEITVQKVIHTEDYRLRLISLKSG--TEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPHcaPIIVHCSAGIGRTGCFIATSICCQQLRQE
. ..... ....|| || ....     |.|  . | .|||||. .|. .  ||.|||.|..| |..| .  ||.||||||.|||| ||| .|  .....|
lvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgag..pivvhCsaGvGrtGvfiavdillerikae

GVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMS
..||...|  |||. |  |.|| .||.|...|. 
alvDvfqtvkqlreqrnlmvqtedqyefiydvll
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 324-553 7e-70 230.6 In-house 58-287 (298) alignment 
Range on Protein: 324-553
Range on HMM: 58-287/298.0
RKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGGEEkVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWPE-EQVAYDG
.||||  |..  .||| |.. | .|  | |||| .. .| |..  .||||.|...||.||||||..|.   |||.||.||... |...|||. ..  |. 
kkNRyadiialdssRvvLeked.adeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketyge

VEITVQKVIHTEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPhcAPIIVHCSAGIGRTGCFIATSICCQQLRQE
.......  .  |.  | . ...   ..|| ...  ||||||. .|  |  .|.|.|.|.   || |   .|.||.||||.||.| ||| .   .....|
itvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvrasqqqagn..kpvivqCsaGvgRsGtfiaidsvlervkke

GVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMS
 |||....   ||..| |..|| ||| |..... 
qvvDvfqvvkvlRkkrpgavqteeqYvfiyeavl
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 324-554 2.3e-69 228.6 In-house 49-277 (288) alignment 
Range on Protein: 324-554
Range on HMM: 49-277/288.0
RKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGGeEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPEEQV--AYD
.||||. |||  . || |.  . . . . ||||.|| |... .|.|||||||. .|| |||..|....|  |||.|.. |. ..|| ||||...    | 
kknRyrnilpyDekrvklkkle.eeagaDYinasyidgekk.kkkyiatqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyG

GVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgphCAPIIVHCSAGIGRTGCFIATSICCQQLRQEG
 |..|.... ..||. || . |.  ..|. ...| ...|||.. |. . |||.|.| |. | |..     |||||||||.|||| |||     .....| 
svtvtlveskeledfvlrklllekkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad...tgpiivhCsaGvGrtgtFialdalidaveeed

VVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSL
..|.. | ..||. |  ..|| .||.|...|.  
yiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_PTPRK_pd Subfamily PTPRK 324-552 3.1e-68 224.9 In-house 45-273 (314) alignment 
Range on Protein: 324-552
Range on HMM: 45-273/314.0
RKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWPEEQVAYDGV
.|||.. ||.  .||| |.. | .|| | ||||..| .|    . .|.||||. .||.||||.|..|..  |||.|.. |    ||..||||.   |. .
eknrsgdilaydrsrvflitid.gdpssdyinaalidsyk.rpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdi

EITVQKVIHTEDYRLRLISLKS----GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQegpHCAPIIVHCSAGIGRTGCFIATSICCQQLRQ
.... ..   ...  |. ...       | | .... |..||| ..|  |  ||.|||.|..  ..   .  .|.|||||| ||||.||| .| .. ...
kvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivldmier

EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
|||||. ..  .||. .  |..| |||.|.. |.
egvvdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 324-555 7.2e-68 223.5 In-house 11-241 (250) alignment 
Range on Protein: 324-555
Range on HMM: 11-241/250.0
RKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGGEeKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWP-EEQVAYDGV
 ||||  |..  .||| | . .  |  | |||| .. || .. | .||||||...|. ||||||..|..  |||.||..|.......||| |.   | .|
eknryadiialdssrvvLekek.gdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekaekyGdv

EITVQKVIHTEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgpHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEG
 ... .  .  ||  | . | .   ..|| .... |..|||.  |. |   |.|...|.   ||   . ||.||.||||.||.|.||| .   ..|..| 
tvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqa..gnaPvivqCsaGvgrsGafiaidavlerlkkek

VVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
|||. |   .||.|| ..... ||| ||....  .
vvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Ptp69D_pd Subfamily Ptp69D 324-555 7.2e-67 220.7 In-house 50-285 (307) alignment 
Range on Protein: 324-555
Range on HMM: 50-285/307.0
RKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWP-EEQVAYDG
 ||||. | .  . || |.     .  |.||||..|.||  |.| .|| |.|. .|. |||||... .  .|||..|..|.|. ||  ||| |..| |. 
lknRyedikafDktRvkLkkin.gkedsdYinasfikgyk.ekkkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygd

VEITVQKVIHTEDYRLRLISLKSGT-------EERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgphCAPIIVHCSAGIGRTGCFIATSICCQ
. ... .  ...||  | ...           ..| .  | .|.|.| | |. |  ||.|...|.|  ...    .||.|||||| ||.| |.| ..  |
ilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelykln...rsPivvhCsaGvgrsgifvaldsllq

QLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
||..|  ||| .|...||..|  ..|  |||.|... .  |
qlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_PTPRG_pd Subfamily PTPRG 324-552 7.1e-65 214.3 In-house 49-283 (563) alignment 
Range on Protein: 324-552
Range on HMM: 49-283/563.0
RKNRYKTILPNPHSRVCLTSPDPDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPEEQV-AYDG
|||||  |..  .||| |..    .    ||||||| ||   .| .||||||. .|. |||||.|.... |||||||  |....||  |||....  |. 
rKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetyga

VEITVQKVIHTEDYRLRLISLKS-----GTE---ERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgphCAPIIVHCSAGIGRTGCFIATSICC
...| ..  ..  |  | ...|      . .   |.  ..| .|.|||. .|. . | |  |.  . | ..|     ||.||||||.|||| .|. .   
lqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaankae...aGPivvHcsaGvgrtGtyivldtll

QQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
.|..|| .|.....  ..|  |  ..|| |||.|.| ..
kqiqqenavnvfgflkhiraqRnflvqteEqYiflhdal
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 324-552 1.9e-61 202.8 In-house 53-280 (297) alignment 
Range on Protein: 324-552
Range on HMM: 53-280/297.0
RKNRYKTILPNPHSRVCLTSPDpDDPLSSYINANYIRGYGGeekVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVA-YDGV
 |.||| |||   ||| | . . ||| | |.|| ...|.      .|.|| |  .||||||.||..|.. .|||... .| ..||. ||... |. .  |
eksRYkniLPydssRvkLaivn.ddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdv

EITVQKVIHTEDYRLRLISLKSGT--EERGLKHYWFTSWPDQKTPD--RAPPLLHLVREVEEAAQQEGPHcaPIIVHCSAGIGRTGCFIATSICCQQLRQ
 .... | . | .  | .... |    .| .| | |..|||.. .   .|. ||.|. ||..  .|.     |..|||.||.|||| ...   .  . ..
svvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg..PllvhclaGvGrtgvlltidsvvaeakr

EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
|  |||...  .|||.|  ..|| |||.||. ..
ekevdifglvkklrqerpylvqtkeqykfvyvav
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 324-561 3.2e-59 195.2 In-house 48-288 (290) alignment 
Range on Protein: 324-561
Range on HMM: 48-288/290.0
RKNRYKTILPNPHSRVCLT-SPDPDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWPEEQV-AYD
..||...|...   |. |   ..  |   .|||| || ||  |.| |||||||. .|..|||...|||...||||.||| |... ||  |||.... ||.
llnRfanivvyddnritLrpisghkDCtneyinAcyikgyk.ekkqyiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkayg

GVEITVQKVIHTEDYRLRLISLKSGTE---ERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGphCAPIIVHCSAGIGRTGCFIATSICCQQLR
 ..|....  ....|. | ...|. ..   .. ...| .|.|...         |....|...   ..|    .|.||||...||.. |.|. .  .. .
efsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg..ntsivvHCSdtvgrsavfcaaattinkck

QEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQLSH
.|||.|...   ..|. . |..|| .|||......  | .... 
tegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfet
subfamily_PTPN13_pd Subfamily PTPN13 324-552 6.3e-55 181.4 In-house 39-265 (273) alignment 
Range on Protein: 324-552
Range on HMM: 39-265/273.0
RKNRYKTILPNPHSRVCLTSPDPddplssYINANYIRGYGGEE-KVYIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPEEQ----V
.||||. .||  ..|| | .  .      ||||..|.   |..  .|||.|||.  ||.|||.|||. .. .|.|.|.  |. . ||  ||||..    .
dknryrnvlPydetrvklgdegg......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkchrywPesknkklk

AYDGVEITVQKVIHTEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqegpHCAPIIVHCSAGIGRTGCFIATSICCQQ
... .|... || . ... .| . .|    .| | . |  |..||| ..|  | .||..|.|| . ..    . .||.|||||||||.| .|.  .  . 
vsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt....dagPivvhcsaGiGrsGtlitidvvlgl

LRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
. ..  .|. ..  .||. | |..|| .|| ||....
ierdkefdvkeivrklreqrqgvvqtkdqyifvykai
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 324-552 3.4e-51 168.8 In-house 35-262 (283) alignment 
Range on Protein: 324-552
Range on HMM: 35-262/283.0
RKNRYKTILPNPHSRVCLTSPDPddplsSYINANYIR--GYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIE-EMNEKCTEYWPEE-QVAY
||||.. |.|    || | |  .     .|||| .|       ..| ||..|.|.  || |||.||..|.   |||.|..  ....||. |||..  . |
rknrnqeivpadqwrvelksesr.....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyWPkrGsedy

DGVEITVQKVIHTEDYRLRLISLKSG---TEERGLKHYWFTSWpdqKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQL
    .|..|    . .  ... |.      ..  | || .  |      .  ...  ||.     ..|   . .||.||||.|||||. ||| |   ...
GeftvtlrkettsnsfiikelllrvnssakstlllahyqvidW...leygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasasvkda

RQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
. | |||. ..   .|..| ...|| .||..||...
ltesvvdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 324-551 1.8e-49 163.4 In-house 50-274 (439) alignment 
Range on Protein: 324-551
Range on HMM: 50-274/439.0
RKNRYKTILPNPHSRVCLTSpDPDDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEkcteYWPE-EQVAYDGV
 ||||| . .  |.|| |    |  | | |||||||.||  ..|.|||||||   |. ||||.|....|  |||.||. |       |||  ..| |  .
tknrykdvgafdhtrvtlqe.ipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlviekktvtivmltnlvesyk....ywpsdaevcygdi

EITVQKVIHTEDYRLRLISL----KSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgpHCAPIIVHCSAGIGRTGCFIATSICCQQLRQ
 . |.. |   .| .| . .     ..  || . .. ...|||.. | .|  .|...| .. | ..|   . |..||||||.||||  ||  |. .||. 
avrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandke..eygpvvvhcsagvGrtGtiialdialeqlkl

EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHV
|  |||      ||..|  |.|.  || |..  
enkvdikgivkvlrkqrkqmvqalcqyvfiyna
subfamily_PTPN1_pd Subfamily PTPN1 324-550 7.2e-48 157.8 In-house 34-265 (290) alignment 
Range on Protein: 324-550
Range on HMM: 34-265/290.0
RKNRYKTILPNPHSRVCLTSPDPddplsSYINANYIRgYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPE----EQVA
 .|||. . |  |||. | . |       ||||. .      .. || ||||...||. ||.|||....  .||. .. |. . ||..|||.    ... 
nlnryrdvspydhsrikleradn.....dyinaslve.leeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeeekell

YDGVEITVQKVI--HTEDYRLRLISLKS--GTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgPHCAPIIVHCSAGIGRTGCFIATSICCQ
.. ....|. .   ... |..||. |.     | | . |. .|.|||   |.    .|... .| |.     ..  | ..||||||||.| |.    |  
ledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsls.sdvGpavihcsaGiGrsGtfclvdtclv

QLRQEGV---VDILKTTCQLRQDRGGMIQTCEQYQFVHH
.. ...    ||| |. ..||. | |.||| .| .| . 
liekkddlssvdikkvllelrkyrlGliqtadqlrfsyl
0041856 (Phosphotyrosine protein) phosphatases II 324-555 6.5e-46 151.5 In-house 3-170 (182) alignment 
Range on Protein: 324-555
Range on HMM: 3-170/182.0
RKNRYKTILPNPHSRvcltspdpddpLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHTPIIVMITnieemnekCTEYWPEEQvaydgve
 ||||. |||..|||            ..|||||...|.    . .||||||  ||||||.||.....  .||..|        .  ||||.        
dknrysdilpydhsr...........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt........eelywpell.......

itvqkvihtedyrlrlislksgteERGLKHYWFTSWPDQKTPDrAPPLLHLVREVEEaaqqegpHCAPIIVHCSAGIGRTGCFIATSICCQQlrqeGvVD
                        ||   .|....|||  .||  . ||....||.|       .  |..||||||.||||...|  .....    | |.
........................erlgiqylylpwpDhgvpd.ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vs

ILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
. .. ...|. | ||..| .||.|.. .. ..
leeavklvrsrRpgmvitpnqyfflqlallel
subfamily_CG7180_pd Subfamily CG7180 324-553 3e-45 149.1 In-house 44-287 (296) alignment 
Range on Protein: 324-553
Range on HMM: 44-287/296.0
RKNRYKTILPNPHSRVCLTSPDPDDPlSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEE-QVAYDGV
 |||. ...|  . || |.. | ..  | |||| |. ..   .| || |..|  .|| .|||.|..|..  .|..|.  ...... .|||.. .  |  .
eknrdvkvvPyDynRvvLekldGeek.sdYinavyvdsfl.kkkeyivteapkketvdefWrlvydeeisavvvLtktfdfakmypsywpnkskeqygei

EITVQKVI---HTEDYRLRLISL---------KSGTEERGLKHYWFTSWPD-QKTPDRAPPLLHLVREVEEAAQQE--GPHCAPIIVHCSAGIGRTGCFI
.. . ..    . . . ..|            .  .|.| .|.. .| |.  .| |  .  |..|.| |.   ..    |. .|..|..| | .|.| ..
fveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdGasRsGvyl

ATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMS
|  .. .....|. ||. .   .||..| ..... |.|...  |..
aidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvll
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 324-555 3.6e-33 109.9 In-house 43-276 (307) alignment 
Range on Protein: 324-555
Range on HMM: 43-276/307.0
RKNRYKTILPNPHSRVCLTSPDpddPLSSYINANYIrGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPEEQV---AY
 ||||. .    ..|. .. .      | || |||. |   . | .|..|||  .|. .|| |. ||.   ..|. .. |  . || .||| |.    ..
dknryqdvkcqdkgrivvkfdg...lasdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqywpleegqklvf

--DGVEITVQK----VIHTEDYRLRLI--SLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEaaqqEgphCAPIIVHCSAGIGRTGCFIATSI
   .  |.|..     .  ..  . .    .. . . | ..|. .. |||. .|.     . |.  |.     .     |..||||||.||.|  .| |.
geapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....d...tnpvvvhcsaGvGrsGtivaisl

CCQQL-RQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
  ... . .   |. |   .||..|   |||  || ..| |.  |
vqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 324-556 5.8e-33 108.9 In-house 50-287 (305) alignment 
Range on Protein: 324-556
Range on HMM: 50-287/305.0
RKNRYKTILPNPHSRVCLTSPDPDDplssYINANYIRGyGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWPEEQVA---Y
 ||||| .    . || | .| | .    || |||.     . | .| || |.  | |||| | .|..   | |. |. |   .||.||.. ..     .
gknrykdvgcldnnrvklegpwphe....yihanyvst.ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlef

--DGVEITVQkVIHTEDY-----------RLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVrevEEAAqqegPHCAPIIVHCSAGIGRTGCF
  .|  |.|. .  .. .           .  |.   .|.. |  .|| .  |||.  |     .| |.   |.|     |   ||.|||||||||||  
eekgqkisvk.fessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailell...ekar....pskgpivvhcsagigrtgsv

IATSICCQQLRQEGV-VDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYE
.     ..|| .  .  |  |   ..|..|   ||| .|| ||| |.  | 
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 325-550 3.4e-56 185.0 In-house 10-234 (239) alignment 
Range on Protein: 325-550
Range on HMM: 10-234/239.0
KNRYKTILPNPHSRVCLTSPdPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPEEQVAYDGVE
||||  |.   |||| |     .|| | ||||.|.| | |  | |||||| .  .  |||||.|||.  .|||.|  ||  ..|| .|||.    |  . 
knryanivtydhsrvvlekl.sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlr

ITVQKVIHTEDYRLRL--ISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEeaaQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGV
.|..|     || .|   .|    |||| . .| || |||.  |. |  .| | |..    ..  | . | ..|||||.||||.|.      .| ...  
vtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit...kdslpgarpwvihcsagvgrtgaflvidamlrqakkqkt

VDILKTTCQLRQDRGGMIQTCEQYQFVHH
|||..    .|.||  |.|| ||| |.| 
vdifnyvkairedrphmvqtseqyvfihl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 325-550 3.5e-56 185.0 In-house 11-235 (239) alignment 
Range on Protein: 325-550
Range on HMM: 11-235/239.0
KNRYKTILPNPHSRVCLTSPdPDDPLSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITN-IEEMNEKCTEYWPEEQVAYDGVE
||||  |.   |||| |     .|| | ||||.|.| | |  | |||||| .  .  |||||.|||.  .|||.|  ||  ..|| .|||.    |  . 
knryanivtydhsrvvlekl.sndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdstskycnlr

ITVQKVIHTEDYRLRL--ISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEeaaQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGV
.|..|     || .|   .|    |||| . .| || |||.  |. |  .| | |..    ..  | . | ..|||||.||||.|.      .| ...  
vtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit...kdslpgarpwvihcsagvgrtgaflvidamlrqakkqkt

VDILKTTCQLRQDRGGMIQTCEQYQFVHH
|||..    .|.||  |.|| ||| |.| 
vdifnyvkairedrphmvqtseqyvfihl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 325-555 4.2e-54 178.5 In-house 50-277 (287) alignment 
Range on Protein: 325-555
Range on HMM: 50-277/287.0
KNRYKTILPNPHSRVCLTspdpdDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPEEQ-VAYDGV
|||.. ||.    || |      .    |||| .| ||  |.| .|....|...|. .||....... ..|||...  |. .|.| .|||||. | .   
knRltqilvpdnyrvllk.....gehpdyinavfidgyk.ekkafiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGey

EITVQKVIHTEDYRLRLISLKSG---TEERGLKHYWFTSWPDQK-TPDRAPPLLHLVREVEeaaQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQ
.|.. .  ....|  | . .|     .... .| | .|.|...   .. .  || . . .    .|  .  ..|.||||...||.. |.|  .  .. ..
niellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyk...tqrkrgntsivvhCsdtvGrsamfcaaattinkckt

EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
|||.|...   . |. . |..|| |||.|. ...  |
eGviDvfqvlksqriqkpgsvqtveqykfindivley
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 325-551 1.6e-53 176.3 In-house 6-234 (237) alignment 
Range on Protein: 325-551
Range on HMM: 6-234/237.0
KNRYKTILPNPHSRVCLTSPDPDdplSSYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEE-MNEKCTEYWPEE--QVAYDG
||||  |    |||| |  .  .   | ||||.|..|. |  | |||.|||. |.  |||.|||||.  .|||.| . |  ..|| .|||.     ||  
knrygnivaydhsrvvlkgagsg...sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaaygv

VEITVQKVIHTEDYRLRLISLKSGTEERG---LKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQ
. ....|  .  || .| . |   .. ..   .. | ||||||.  |...  || . ... . ..   ....| |.|||||.|||| |.      .| ..
ltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsp.hvsesgpwiihcsagvgrtgiflvidamlrqake

EGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHV
. |||| .    . .||  .||| .|| |.|..
kkvvdiynyvysieedrpyiiqtkdqyvfihqt
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 325-555 1e-45 150.8 In-house 43-292 (301) alignment 
Range on Protein: 325-555
Range on HMM: 43-292/301.0
KNRYKTILPNPHSRVCLTSPDP-DDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWPEE---QVAY
 ||.| | . .. |. |.     |    .||||.|| ||  |.| .||.|||. .|..||||..|||..  |||.|| .|  ..||..|||.    .  .
lnrfknitvyddnriilkpkpnldlcqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseef

DGVEITVQKVIHTEDYRLRLIS-----------------LKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQegPHCAPIIVHCSAGIGR
  ...|...     |. .| ..                  ||  . . .  .  |.||..         |. . .|  . |.  .  .|..||||....|
gpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtvLqviddvihrqqk..igggpvvVHCSdtVsr

TGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
.| ... ||   | . |||||. . |  .|. . |...| ||| ... |.. |
sGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 325-556 4.9e-35 115.8 In-house 36-259 (267) alignment 
Range on Protein: 325-556
Range on HMM: 36-259/267.0
KNRYKTILPNPHSRVCLTSPDPDdplssYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNekCTEYWPEE-QVAYDGVE
.||.   ||  ..|| |   . .     |||| |. ||   .. .|.||.|.  |..||. .. ... |.||..|.. . |     .|| .   |    .
rnrlddnlpyddtrvilrtkeee.....yinasyvegyk.tknafivtqdplkntitdfltvihdqkvpvivlltkvftdn..irlfwPPkmgqakkyqd

ITVQKVIHTE--DYRLRLISLKSGTEE-RGLKHYWFTSWPDQkTpDRApPLLHLVREVEEAAQQEgPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEG
.||.. .  |  ||..  . ||   |  . .  |..  |  . | .   | |. .  .    | |     |..|.||.|.||.| |.      .....||
ltvehslekeendyqiitlelkfknesahnvtlyyykkwnin.t.nnk.pylkplfgilaknqle.ngnrPlvvacsdGvGrsGtflvidsqlerakteg

VVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYE
|.|| .   ..|. | |...| |.| ..|.... | 
vsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 325-548 3.8e-31 102.9 In-house 53-273 (301) alignment 
Range on Protein: 325-548
Range on HMM: 53-273/301.0
KNRYKTILPNPHSRVCLTSpdpdDPLSSYINANYIRGYgGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMIT-NIEEMNEKCTEYWPE---EQVAYD
|.||.|.  .|.. | . .    |     | ||.|    |. . .||||||. .|  ||| |. | .   |||.. ..|...|||.|| |    |..  .
khryptvPckPstaveviv....dGkrvPihanwipts.GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig

GVEI--TVQKVIHTEDYRLRLISLKSGTE---ERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqegphcaPIIVHCSAGIGRTGCFIATSICCQQ
  .|  . ...|  ..   | . ..  |.    | . || ...|.|. .|     | .|.  | .. .       ||.|||||||||. .||.| .  ..
rfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek.......PivvhcsaGiGrsvafigteylare

LRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFV
.  .  ... ..  .||..|   .|| .|  ..
veadptieltealkhlrehrwngvqtnsqlywm
subfamily_egg_pd Subfamily egg 325-556 2.9e-28 93.4 In-house 43-270 (307) alignment 
Range on Protein: 325-556
Range on HMM: 43-270/307.0
KNRYKTILPNPHSRVCLTSPDPdDPLSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMnEKCTEYWPE---EQVAY--
| | | .  .  ||| |  .     |  .| ||...|       .| .| |.  || ||||||.||. . |||.|   |  |.|  |||    . . .  
karskrvhckdssrvklelrrG.qylddfihanrvkGkp.llnefilaqaplkntvddfwrmvfqeevqyivmltsrkes.erceyywpkaesdslvtvp

DGVEITVQKVIHTEDYRLRLISLKS---GTEERGLKHyWftSWPDQKTPDRAPPLlHLVREVEEAAQqegphcaPIIVHCSAGIGRTGCFIATSIC-CQQ
 ...|.  || .. |  .|.  ||      ||| |.| |   .  ... |   || ...| . ....       |..|..  |. ......|  |  .. 
GslrienlkvdskadplfrvtklklvGgddeerfleh.w..qgdvnnssdvyspl.rvlrklrnlsk.......pvvvqdilGvskaatlvaieiallsl

LRQEGVVD-ILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYE
||   .   .|..   ||. |   ...  .| ||. .. .. 
lrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 325-553 2.7e-27 90.6 In-house 46-268 (288) alignment 
Range on Protein: 325-553
Range on HMM: 46-268/288.0
KNRYKTILPNPHSRVCLTspdpDDPlSSYINANYIRGYGgEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPEE--QVAYDG
..||. .     .|| |.    |||   ||.|| .      ..  | .| |. .|.  .|.|. ..    |||.... |   ||  ||.| .  . |  |
rdryenlprcditrvkls....ddp.dfyiaanvvssak.ykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarig

VEITVQKVIHTEDYRLRLISL----KSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVeeaaqqeGPHCAPIIVHCSAGIGRTGCFIATSICCQQLR
   || |. ...  .|  .||    | | |.  .|.  .  |.|.  |.   . |.|.  .         .  ||.||.|||.|||| .| . |  ..||
rlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.......kslqkPivvhssaGvGrtgtlililialeslr

QEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMS
 .  . | .   .||..|   |||. || .|| .. 
lddflgirsllaklreerfkaiqtemqylyvhrcvl
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 326-554 6.5e-29 95.8 In-house 39-268 (285) alignment 
Range on Protein: 326-554
Range on HMM: 39-268/285.0
NRYKTILPNPHSRVCLTSPDPDdplssYINANYIRGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMI-TNIEEMNEKCTEYWPE---EQVAYDG
|||  .     .|| |   | |     || |...|  | ..  ||.||||.  |..|||.|..||.   ..|. | .|   |||. |.||   | | .  
nryadvrcieetrvvlknhdrd.....yihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevvkfgk

VEITVQKV-----IHTEDYRLRLISLKSGTE-ERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgphcAPIIVHCSAGIGRTGCFIATSICCQQ
 |||. ..       |    | .|  .  .     ..|     |||| .|. | |.. | . |..   .|     || ||||||.|||  |.    .  .
yeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpke....kpicvhcsagvgrtatfvgidyatir

LRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSL
. ..  ...|    ..|  |   .|.  |. |.. |.  
imenpniemldivremramrfqavqshmqflflyvvlme
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 326-411 3e-06 20.9 In-house 38-120 (332) alignment 
Range on Protein: 326-411
Range on HMM: 38-120/332.0
NRYKTILPNPHSRVCLTspdPDDPLSSYINANYIRGYGgEEKVYIATQGPIVS-TVADFWRMVWQEHTPIIVMITNIEEMNEKCTEY
||   .    |||| |.   |.|    . ||... ||  ..  || .| |.   |   ||||| . .  .|... .|.| ... . |
nriphlycfdhsrvela...pqdgkddfynaswvdgys.kksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapy
0044763 (Phosphotyrosine protein) phosphatases II 334-553 6.6e-32 106.0 In-house 2-168 (178) alignment 
Range on Protein: 334-553
Range on HMM: 2-168/178.0
NPHSRVCLTSPdPDDPLSSYINANYIRGYggeekVYIATQGPivstvADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWPEEQVaydgveitvqkviht
 ...||.|... .. . | ||||..| ..     .|.....|     ||.........   ||..|.  |.. .|| .|||||                 
ldrtrvllsnl.eglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

edyrlrlislksgteerglKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGphcAPIIVHCSAGIGRTGCFIATSICCQQlrqeGVvDILKTTCQLR
                    .| .. .|| ..||    .| .|. .||| ...|    |..||||||.||.|...|  .....    |. .. .   ..|
...................iqylhipipDhgvpdllehflefvefieealdekg...gpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvr

QDRGgMIQTCEQYQFVHHVMS
. |  .... .|..... . .
erRp.ivpnpgqlrqLyefel
0046846 (Phosphotyrosine protein) phosphatases II 345-557 5.1e-42 138.9 In-house 6-174 (176) alignment 
Range on Protein: 345-557
Range on HMM: 6-174/176.0
DPDDPLSSYINANYIRGYggeekVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWPEeqvaY----Dgveitvqkvihtedyrlrl
. .|. ..|||||.| |.      .||||||...|.|||..|.....  ..|..|.  |..  ||. ||||    .                        
lgldldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe....leklgi...................

islksgteerglkHYWFTSWPDQKTPDRaPPLLHLVREVEEAAQQEgphcAPIIVHCSAGIGRTGCFIAtsicCQQLRQEGVVDILKTTCQLRQDRG-GM
             .|... |||  .||    ||.|.....|| ..      |..|||||||||||...|    .  |. |  ...... ...|. |  |.
.............qylhlpwpDhgvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlva....ayllelekglsveealalvreqRplga

IQTCEQYQFVHHVMSLYEK
.|| |||.|..... |. |
vqtpeQyrflyefellllk
0043147 (Phosphotyrosine protein) phosphatases II 348-550 1.4e-37 124.4 In-house 2-155 (172) alignment 
Range on Protein: 348-550
Range on HMM: 2-155/172.0
DPLSSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIeemnekcteywpeeqvaydgveitvqkvihtedyrlrliSLKSGTE
|. | ||||.|. .|    . .||||||  .|.||||||.....  .||..|.                                         .    .
degsdyinasyldlyyipdr.fiatqgplrntladfwrmlkelgithivnltel.......................................lydpell

ERGLKHYWFTSWPDQKTPdRAPPLLHLVREVEEAAQQEGPhcAPIIVHCSAGIGRTGCFIATSICCqqlrqeG-VvDILKTTCQLRQDRGGMIQTCEQYQ
||   .|....|||. .|  .  ||.... ..|.....     |..||||||.||||...|  ...        . ..... ...|. |.|..|. .||.
erlgiqylylpwpDhgvp.llellleflefidellalspg..gpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqyr

FVHH
|...
flyy
0051429 (Phosphotyrosine protein) phosphatases II 349-555 1.9e-45 151.0 In-house 2-224 (272) alignment 
Range on Protein: 349-555
Range on HMM: 2-224/272.0
PLSSYINANYIRGYgGE---EKVYIATQGPIVSTVADFWRMvWQEHTPIIVMITNIEEMN-EKCTEYWP-------------EEQVAYDGVEITVQKVIH
|||.||||... || |    ........||   |.|||||. ....   ||.... ||.. .||  |||             .... |  . .|......
plsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseel

TEDYRLRLISLK---SGTEERGLKHYWFTSWPDQKTPDRAppLLHLVREVEEaaqqegphCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVD-----
..|| || . |.   | .| | . |...|.|||  .|. |  ||.|.... .          |..||||||..|||...|  .. ...  | .||     
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---ILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
   ....  .||. | |..|| |||.|.....  .
nlyleeaveelraqrpgavqteeqylflyeallel
0051082 (Phosphotyrosine protein) phosphatases II 349-551 2.6e-34 113.3 In-house 1-148 (151) alignment 
Range on Protein: 349-551
Range on HMM: 1-148/151.0
PLSSYINANYIRGYggeekvYIATQGPivstVADFWRMVWQEHTPIIVMITNIEEMNeKCTEYWPEEQvaydgveitvqkvihtedyrlrlislksgtee
|||.|||..|. |.      .....||     |||........   ||.... ||.. .|.||.||..                                
plsdyinfsyvtgg......lyrsggp....ladflellkelgiktivnlrseeerg.ycpeylpelg................................

RGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEaaqqegPHCAPIIVHCSAGIGRTGCFIATSICCQQlrqegvVDILKTTCQLRQDRGGMIQTCEQYQFV
. ..|.....|||...|.  . .|........      .   |..||||||.||||...|  .....      |.. ..  ..|. |.|..|. .|..|.
ievlhipildwpdpglplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfq

HHV
...
lfa
0036282 (Phosphotyrosine protein) phosphatases II 351-550 2.1e-41 136.9 In-house 2-164 (174) alignment 
Range on Protein: 351-550
Range on HMM: 2-164/174.0
SSYINANYIRGYGGEEkVYIATQGPIVstvadFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWPEeqvaydgveitvqkvihtedyrlrlislKSGTEER
|.||||... ..   .  .||.|||       ||.|.....  ..|| .. .|.. .||  ||||                            ..  .||
sdyinaspldlsyitp.rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe............................lredler

GLKHYWFTSWPDQKTPDRAPpLLHLVREVEEAAQQegPHCAPIIVHCSAGIGRTGCFIATSICCQQLRqEGVVDILKTTCQLRQDRGGMIQTCEQYQFVH
   .|... |||  .|| .  ||..|..|||| ..  ..  |..||||||.||||...|  .....|. |..||.|..  .||. |.||.|| .||.|..
lgiqylylpwpDhgvpdlsi.llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

H
 
y
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 351-557 6.8e-21 69.3 In-house 67-279 (312) alignment 
Range on Protein: 351-557
Range on HMM: 67-279/312.0
SSYINANYIRGYGGEEKvYIATQGPIVSTVADFWRMVWQ-EHTPIIVMITNIEEMNEKCTEYWPEE--------QVAYD--GVEITVQ-KVIHTEDYRLR
  || ||...     |. ...||||. .|.. ||...     | ||.... .|. .|||..|  .         .  |     || .  |      .|. 
nfyihanfvkictkper.fvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvl

LISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQqegphcaPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGM
 . .|.  .|  |.|| ..||||.  ||     | |.  |    .       |.| |||||.|||| ..        ||.    .. ..   ||.||   
kvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.......pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrars

IQTCEQYQFVHHVM--SLYEK
...  || .. ...   || |
vrvfpqyvyalrcvleflysk
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 352-561 1.5e-25 85.0 In-house 47-264 (290) alignment 
Range on Protein: 352-561
Range on HMM: 47-264/290.0
SYINANYIRGYGGeeKVYIATQGPI-------VSTVADFWRMVWQEHTPIIVMITNIEEMNEK-----CTEYWPE---EQVAYDGVEITVQKVIHTEDYR
 || ||..    |     |.|| |         ||. .|| |. ||.   .||. . || ...     |..| ||   |.. ..|...  .. .. .|  
dyiHAnrvtcpng..lrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

LRLISLKSG-TEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEeaA-QqegphcAPIIVHCSAGIGRTGCFIATSICCQQLR-QEGVVDILKTTCQLRQ
 | . .| .  ||  ..|... .| . ....    ||.|.. |.  | .      .|.||||  || |  .. |  . .| .  ..| | . .   .||.
tRelvvkfddeeeftvtHsllkgWnklnvqedtktllsliqkvk..ask......tpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

DRGGMIQTCEQYQFVHHVMSLYEKQLSH
 |  .|.. ... ||  .. |. ..  .
qralaitsalelafvdagivllaievld
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 352-427 2.6e-09 31.5 In-house 14-85 (130) alignment 
Range on Protein: 352-427
Range on HMM: 14-85/130.0
SYINANYIrGYGGEEKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNekctEYWPEEQ-VAYDGVEITVQ
 ||||... |  |  . |. || |.  |  |||.|. . .  ..|..  .|| .    ||||. . . .   .|.| 
tyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed....eywpdsePlewyeediivt
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 366-413 7.8e-09 29.3 In-house 235-280 (440) alignment 
Range on Protein: 366-413
Range on HMM: 235-280/440.0
EKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEmnEKCTEYWP
 . .|||| |. ||| ||||.| . .   |.|. ....    |. |||
knafiatqmpldstvldfwrlvhdyristiimlnqlnd..ktcsiywp
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 366-426 4e-08 27.2 In-house 136-193 (244) alignment 
Range on Protein: 366-426
Range on HMM: 136-193/244.0
EKVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNekctEYWPE-EQVAYDGVEITV
   || || |.  |  |||.|. . |  ..|..  .|| .    ||||. | . .   .|||
taeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed....eywpdseplewyeeditv
0049260 (Phosphotyrosine protein) phosphatases II 367-550 7.9e-34 111.9 In-house 9-144 (152) alignment 
Range on Protein: 367-550
Range on HMM: 9-144/152.0
KVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMN-EKCTEYWpeeqvaydgveitvqkvihtedyrlrlislksgteerglkHYWFTSWPDQKTP
. .||||||   |.||||||... .  .|||.|. .|.. .|| .|.                                        .| .. |||  .|
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi........................................qylhlpwpDhgvp

DRAPPLLHLVREVEEAAQQEGPhcaPIIVHCSAGIGRTGCFIATSICCqqlrqeGVVDILKTTCQLRQDRGGMIQTCEQYQFVHH
| .  || |.. .|..|...|    |..||||||.||||...|  ...        |.....  ..|. | |.... .|..|.. 
dlsqlllflllfieklaldkgg...pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 367-550 1.2e-30 101.2 In-house 5-198 (199) alignment 
Range on Protein: 367-550
Range on HMM: 5-198/199.0
KVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWPEEQV---AYDGVEITVQKVIHTEDYRLRLISLKSGT----EERGLKHYWFTS
. ||||| |.  |.||||.|||.  .  |||. . .  .|     |||  .     |  . .|.. .    || .  . | . |      | . || |||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQL--RQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHH
| .. ||. |  .  .|   | . . |  . ||.||||| | | || |.|  |  .     .  |||... . .||| | |.| . ..|.|.. 
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 367-550 1.2e-30 101.2 In-house 4-197 (198) alignment 
Range on Protein: 367-550
Range on HMM: 4-197/198.0
KVYIATQGPIVSTVADFWRMVWQEHTPIIVMITNIEEMNE-KCTEYWPEEQV---AYDGVEITVQKVIHTEDYRLRLISLKSGT----EERGLKHYWFTS
. ||||| |.  |.||||.|||.  .  |||. . .  .|     |||  .     |  . .|.. .    || .  . | . |      | . || |||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDQKTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQL--RQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHH
| .. ||. |  .  .|   | . . |  . ||.||||| | | || |.|  |  .     .  |||... . .||| | |.| . ..|.|.. 
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 369-558 2e-20 67.4 In-house 92-287 (302) alignment 
Range on Protein: 369-558
Range on HMM: 92-287/302.0
YIATQGPIVSTV---ADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWP---EEQVAYDGVEITVQKVIHTEDYR--LRLISLKSGTEERGLKH-YWFTSW
 | .| |.|...   ..|||||.||.   .|..   ||...   |..|   .. . |. . . ..|| ..|. .  . .  |  |  .  |   | .| |
iilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnW

PDQKTPDRAPPLLHLVREVeeaAQQEGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQ
...| |..   | . . .|    ... .  .....    |.|| | |..  .  ..| ..  . |  .  ..|..|  ......|| ... .. || |.
kqkkvpvkyaeliktaakv...fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikk
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 372-548 3.8e-14 46.8 In-house 96-280 (302) alignment 
Range on Protein: 372-548
Range on HMM: 96-280/302.0
TQGPIVSTVADFWRMVWQEHTPIIVMITNI-EEMNEKCTEYWPEE---QVAYD-------GVEITVQKVIHTEDYRLRLISLKSGTE----ERGLKHYWF
   |  ||.  .| .. | .. |.| .... |. ..||.||. ..   .. .         |.  ...    ....|  . .|        .. ..   |
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilaf

TSWPDQKTPDRAPPLLHLVREVEEAAQQegphcapIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFV
..|||  .|. | . |....  |   ..       ..||||||.|||| ..|     |   .. | |.|.  . .|| | | .|. .|  ..
sawpdhGapkeaytaldilkfcesykkn.......vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_hpo-7_pd Subfamily hpo-7 376-548 1.2e-18 62.0 In-house 43-219 (263) alignment 
Range on Protein: 376-548
Range on HMM: 43-219/263.0
IVSTVADFWRMVWQEHTPIIVMITNIEEM-NEKCTEYWPEE---QVAYDGVEITVQKVIHteDYRLRLISLKSG----TEERGLKHYWFTSWPDQKTPDR
.| |.. |.... |  |  .||... .|   ||| .|.| |   .  .  |.... ||..  |  |. . | |      . ...||| .. |.... |  
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

APPLLHLVREVEEAaQqegphcaPIIVHCSAGIGRTGCFIATSICCQ----QLRQEGV--VDILKTTCQLRQDRGGMIQTCEQYQFV
|   |.... . .  .       ...||||.||||.  |  . .  |    .|..     .| |.   .||. | . |.|  |  | 
areilnilkvarns.k.......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafs
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 376-551 4.9e-07 22.7 In-house 127-304 (346) alignment 
Range on Protein: 376-551
Range on HMM: 127-304/346.0
IVSTVADFWRMVWQEHTPIIVMITNIEEMNEKCTEYWPEEQVAYDGV---EITVQKVIHTEDYRLRL-ISLKSGTEERGL-KHYWFTSWPDQKTPDRAPP
  | | ||| |..||.  .. ..   . ...  |  . .|.  |.      |  ..   . | .      |  |  .  . . .  . |   . | .. |
nesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlp

LLHLVREVEEAAQQegpHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHV
..... .     |    . | . |    | ||. .|| .    .|| .    .|..   ...|.| | ...  ||  .. .
iikmihqflsekqv...qnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyai
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 379-548 6.6e-20 66.3 In-house 40-213 (255) alignment 
Range on Protein: 379-548
Range on HMM: 40-213/255.0
TVADFWRMVWQEHTPIIVMITNIEE-MNEKCTEYWPEE---QVAYDGVEITVQKVIHTEDYRLRLISLKSG--TEERGLKHYWFTSWPDQKTPDRAPPLL
||. |.... |  |  .||... .|   ||| .|.| |   .  .  |..|. | .     | . | .. |   . . .||| .. |.....|. |  .|
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelareil

HLVREVEEAaQqegphcaPIIVHCSAGIGRTGCFIATSICCQ----QLRQEG--VVDILKTTCQLRQDRGGMIQTCEQYQFV
.... | .. .       ...||||.||||.  |. . .  |    .|..     .| |.   .||. | . |.|  |  | 
nilkvvrds.k.......svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafs
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 417-551 7.5e-23 75.5 In-house 57-189 (440) alignment 
Range on Protein: 417-551
Range on HMM: 57-189/440.0
VAYDGVEITVQKVIHTEDYRLRLISLKSGTEERGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGphCAPIIVHCSAGIGRTGCFIATSICCQQL
.|||   . ...|    |      |  .| | | ||.| . .|||.  |  | |.|.....|.|. .. |   .|..|||||| ||||  ||     .. 
laydhsrvmleevkgvpdsdyinasyingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekag..ngpllvhcsagagrtgviiavdsilrea

RQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHV
..   .||.     .|..|  |.|| ||| |||..
krsdqidifsfinsmrnnrpqmvqtpeqyafvhea
0048076 (Phosphotyrosine protein) phosphatases II 440-552 2.8e-22 74.4 In-house 37-139 (145) alignment 
Range on Protein: 440-552
Range on HMM: 37-139/145.0
ISLKSGTEeRGLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgphcAPIIVHCSAGIGRTGCFIatsiCCQQLRQEGvVDILKTTCQLRQDRGGMI
 | ... | |   .|....|||  .|| .  ||.... .||| ...     |..||||||.||||...    ..  ....| |.. ..  ..|. | |..
tselelle.rlgiqylylpwpDhgvpdllellleflefieealkeg....gpvlVHCsaGvgRtgtlv....aaylmlllg.vsleealelvrsqrpgav

QTCEQYQFVHHVM
.. .|..|.. . 
pnpgqlrflyefe
subfamily_PTPDC1_pd Subfamily PTPDC1 449-552 8.1e-08 26.9 In-house 81-172 (182) alignment 
Range on Protein: 449-552
Range on HMM: 81-172/182.0
RGLKHYWFtSWPDQKTPDRaPPLLHLVREVEEAAqQEGphcaPIIVHCSAGIGRTGCFIATSICC-QQLRQEGVVDilkttcQLRQDRGGMIQTCEQYQF
.|. .| | .|.| ...     .| .|. |. |  |||     . ||| || ||||  ||. .   ..|  |  ..       .|. |   ||| || ..
qgiyvynf.gwkDygvasl.eriLdivkvvafal.qeg....kvavhChaGlGrtGvliacylvyakrltaekaik......lvrskrpksiqtreqvel

VHHVM
|.. .
vkefa
0048179 (Phosphotyrosine protein) phosphatases II 450-550 5.4e-21 70.3 In-house 48-139 (144) alignment 
Range on Protein: 450-550
Range on HMM: 48-139/144.0
GLKHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEgphcAPIIVHCSAGIGRTGCFIATSICCqqlrQEGvVDILKTTCQLRQDRGGMIQTCEQYQFVH
   .|....|||  .|| .  ||.... .||| ...     |..||||||.||||...|  ..      .| ... ..  ..|. | |.... .|..|..
egiqylhlpwpDhgvpdllellleflefieealeeg....gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlrfLl

H
 
e
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 450-548 3.9e-07 23.9 In-house 228-330 (347) alignment 
Range on Protein: 450-548
Range on HMM: 228-330/347.0
GLKHYWFTSWPDQKTPDRAPPLLHLVRE-VEEAAQQ---EGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQY
  | |  |.|| .| ||    .| |||  | |...    .  . ||..| |  |. |.   . |||  .|. .    |  .   ..|..| |..     |
fakvyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcddlfkkmrdqragvftmsify

QFV
 . 
tya
PTPc_DSPc_SM00012 452-552 3.1e-34 112.7 In-house 3-103 (105) alignment 
Range on Protein: 452-552
Range on HMM: 3-103/105.0
KHYWFTSWPDQKTPDRAPPLLHLVREVEEAAQQEGPhCAPIIVHCSAGIGRTGCFIATSICCQQLRQE-GVVDILKTTCQLRQDRGGMIQTCEQYQFVHH
|||..|.|||...|... ..|.|.|.|..  ....   .|..||||||.||||.|.| .|..|||..| . |||... ..||. | ||.||.|||.|...
khyhytgwpdhgvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VM
..
al
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 456-557 1.6e-10 35.0 In-house 197-291 (310) alignment 
Range on Protein: 456-557
Range on HMM: 197-291/310.0
FTSWPDQKTPDRApplLHLVREVEEAAQQEGphcaPIIVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLY
.  |||.  ||      | | .   |  . |    | .||||||..|... .|  .  ..|..   ||. .   .|...|   |||  || ....|. ..
wpnwpdrgvpdek...chtvpqrllaqvrhg....pcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif

EK
 .
ar
0038934 (Phosphotyrosine protein) phosphatases II 459-553 7.3e-08 27.8 In-house 87-174 (194) alignment 
Range on Protein: 459-553
Range on HMM: 87-174/194.0
WPDQKTPDRAPPLLHLVREVEEAAQQEGPHcaPIIVHCSAGIGRTGCFIATSICCQqlrqeGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMS
.||. |.     ||. .. |.|  ..  ..   . ||| ||.||||...|  . .         .  .    .|. |.|.|.. .... ..  ..
fpddgtvPsleillrfldlvdeflnedpgg..vvaVHCkaGlgRtGtlvaaYLiyr.....lgmsaeeAialfrekRpgaipnqdyleallkryk
subfamily_CDKN3_pd Subfamily CDKN3 459-560 2.9e-07 24.3 In-house 107-200 (202) alignment 
Range on Protein: 459-560
Range on HMM: 107-200/202.0
WPDQKTPDRAPpLLHLVREVEEAAQQegphCAPIIVHCSAGIGRTgCFIATsicCQQLRQEGVVDILKTTCQLRQDRG-GMIQTCEQYQFVHHVMSLYEK
 .|  .|| |   |... |.  . ..        .|||  |.||. .....   |  |  . ...  ..  .||. .| . |||  ||.....     |.
iadglvpdias.clkileelrinlka....yrktlvhcygglgrs.slvia...clllylddtiepkdaidklrdlkgsraiqtvkqynylsefrdklee

QLS
 ||
yls
subfamily_DSP23_pd Subfamily DSP23 463-557 2.3e-07 25.6 In-house 58-147 (148) alignment 
Range on Protein: 463-557
Range on HMM: 58-147/148.0
KTPDRAPPLLHLVREVEEAAQQEGPHCAPIIVHCSAGIGRTGCFIAtsicCQQLRQEGVvDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEK
. .|  || |. | |  .  ..   .   . |||  | |||| ..|    |  ......    ..  ..|. | | ..| || . |..  ....|
riddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmla....cylvkerkl.aaaeaiaevrrlrpgsvetveqeklvrdyetfink
subfamily_PTEN_pd Subfamily PTEN 465-558 6.8e-07 24.4 In-house 88-182 (184) alignment 
Range on Protein: 465-558
Range on HMM: 88-182/184.0
PDRAPPLLHLVREVEEAAQQ--EGPHCAPIIVHCSAGIGRTGCFIATSICCQQLRqEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQ
 |  || |.|..|. | ...  |  .   ..||| || ||||  |.. .  ..|  |   ..|.   . |   .  ..   |  .|... .|.|..
dDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslll.ekaeealelfaeaRtknkkgvtiPsqrRYveYyeklleee
PTEN_1 467-508 2.1e-06 22.7 In-house 106-149 (196) alignment 
Range on Protein: 467-508
Range on HMM: 106-149/196.0
RAPPLLHLVREVEEAAQQEG--PHCAPIIVHCSAGIGRTGCFIA
 ||.| .| .........    |.   ..||| ||.||.|. .|
gapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 483-556 8.2e-09 29.6 In-house 256-344 (350) alignment 
Range on Protein: 483-556
Range on HMM: 256-344/350.0
QQEGPHCAPIIVHCSAGIGRTGCFIATSICCQ------QLRQE--------GVVD-ILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYE
  .  . .||.||||||.|||| ...     .      .|..|         . | |  .  .||. |  |.|. .|. |... .  | 
hldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_CG42327_pd Subfamily CG42327 490-559 8.9e-19 62.3 In-house 248-318 (319) alignment 
Range on Protein: 490-559
Range on HMM: 248-318/319.0
APIIVHCSAGIGRTGCFIATSICCQQLRQE-GVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVMSLYEKQL
 |..|||| |.||||  ||. |  ..| .    ||| ..  ..|.||.  ..| |||.|...|.| | |.|
GPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakkl
subfamily_CDC14_pd Subfamily CDC14 490-551 4.3e-06 20.8 In-house 264-320 (328) alignment 
Range on Protein: 490-551
Range on HMM: 264-320/328.0
APIIVHCSAGIGRTGCFIATSICCQqLRqegvVDILKTTCQLRQDRGGMIQTCEQYQFVHHV
  |.||| ||.||||..||. .  .  |    .    .   ||  | |.. .  |  .... 
GaiavhCkaGLGrtGtLiacylmkh.yr....ftaaeaiawlricrPGsvigpqqkfleekq
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 493-551 8.4e-11 36.1 In-house 2-60 (69) alignment 
Range on Protein: 493-551
Range on HMM: 2-60/69.0
IVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHV
.||||.| |||| |||  .   ... | .|||.     .|. |  |.    .| |.|  
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihda
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 493-552 8.6e-11 36.0 In-house 1-60 (69) alignment 
Range on Protein: 493-552
Range on HMM: 1-60/69.0
IVHCSAGIGRTGCFIATSICCQQLRQEGVVDILKTTCQLRQDRGGMIQTCEQYQFVHHVM
.||||.| |||| |||  .   ... | .|||.     .|. |  |.   ..| |.|  .
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdal