Gene PTPN11 in Homo sapiens

Synonym: BPTP3, CFC, NS1, PTP-1D, PTP2C, SH-PTP2, SH-PTP3, SHP2, PTPN11

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN6
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP085_AA protein Get Run
HsapP085_AA_229-527 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
SH2 SH2 domain 6-81 1.3e-26 83.0 Pfam-A 1-77 (77) alignment 
Range on Protein: 6-81
Range on HMM: 1-77/77.0
WFHPNITGVEAENLLLTRGVDGSFLARPSKSNPGDFTLSVRRNGAVTHIKIQNTGDY-YDLYGGEKFATLAELVQYY
|.| .|.. |||.|||... ||.|| |.|.|.|||.||||...| |.|..||.. .  | . ..||| .|.|||..|
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddgkvkhyriqslengkyyitenekfsslqeLvehY
SH2 SH2 domain 112-197 2.1e-27 85.6 Pfam-A 1-77 (77) alignment 
Range on Protein: 112-197
Range on HMM: 1-77/77.0
WFHGHLSGKEAEKLLTEKGKHGSFLVRESQSHPGDFVLSVRTGDdkgesndgksKVTHVMIRCQELK-YDVGGGERFDSLTDLVEHY
|.||..|..|||.||.|..|.|.||||||.|.|||..|||.. .          ||.|. |...| . | . ..|.|.||..|||||
WyhgkisreeaerlLlegkkdGtFLvReSeskpGdytlsvvddg..........kvkhyriqslengkyyitenekfsslqeLvehY
0050432 (Phosphotyrosine protein) phosphatases II 215-530 1.5e-99 328.5 In-house 13-303 (308) alignment 
Range on Protein: 215-530
Range on HMM: 13-303/308.0
PLNTTRINAAEIESRVRELSKLAETtDKVKQGFWEEFETLQQQECklLYSRKEGQRQENKNKNRYKNILPFDHTRVVLhdgdpnEPVSDYINANIIMPEF
..  | |..  .. .| .| || |   . .....||||.|... .  |.... ....|||.|||||.|||.||.||.|      .. ||||||. ..  .
lfrdtsilvsslklsvldllkllek.aldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl......degsdYInAsyvdgys

etkcnnSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDE--YALKEYGVMRVRNVKESAAHDYTLRELKLSKVGqallq
      || .. .|||||.|.|||.||||||...|.||||| ||.||.|. || .|||.|     .||| ..|....|   .|||.|.|.|...|     
......sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg.....

GNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESimdaGPVVVHCSAGIGRTGTFIVIDILIDIIREKgvdCDIDVPKTIQMVRSQRSGMVQTE
.. .|||...|. .|||||||..|  .|||||.|......    ||.|||||||.|||||||..|.|.. ....   . .||.......|.|| |||||.
dgesrtvthfhytnWpdhgvPpspeilldflelvrkslpg....gpivVHCsaGvGRtGtfialdllleqleke...ggvdvfeavkklReqRpgmvqtp

AQYRFIYMAVQHYIETLQ
 ||.|.|.|...|.....
eqylflyralleylklkl
subfamily_PTPN6_pd Subfamily PTPN6 219-534 1.1e-145 479.3 In-house 2-304 (306) alignment 
Range on Protein: 219-534
Range on HMM: 2-304/306.0
TRINAAEIESRVRELSKlaETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHdgDPNEPVSDYINANIIMPEFETKC
|...|.|||.||.||.|  |.... |.||.||||.|||.|.| |.|||||...|||.|||||||||||||||.|.  .|. | |||||||.|. |.....
tsllakeieqrvselek..eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk..epsvpgsdyinanyikkevkgsd

nnskpkKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVgqalLQGNTERT
      ||||||||||..||.||||||.||||||||||||||||||.||..||||| . .|||...|.||.|....||.||||..||.     ....||.
......ksyiatqgclettvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk....kkkkeere

VWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIM--DAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYR
|.||||..|||||||.||| ||||||.|..|||...  .|||.||||||||||||||||||||...|..||.|.|||. |....||.||||.||||.||.
vfqyhfksWPdhgvpkdpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqyk

FIYMAVQHYIETlQRRIE
|.|.|...|||| ....|
fvykaikkyiet.kkkle
0051299 (Phosphotyrosine protein) phosphatases II 219-526 6.8e-96 316.4 In-house 3-286 (288) alignment 
Range on Protein: 219-526
Range on HMM: 3-286/288.0
TRINAAEIESRVRELSklaettDKVKQGFWEEFETLQQQECKllYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPnEPVSDYINANIImpefetkc
|.|.. |....|..|        . . |..||||.|... ..  .... ....||..||||..|||.||.||.|.. |. .. ||||||. |        
teisveellklvlkll......angltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldg.vegsdYinAsyi........

NNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDeYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQaLLQGNTERT
.  . |. .|||||.|.|||.||||||...|.||||| ||.||.|. || .|||.    ..|| ..|....|   .|||.|.|......  | .....||
dgynlkrkfIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseevlddytvrtlevtnldl.ldgdgesrt

VWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQEsiMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKgvdCDIDVPKTIQMVRSQRSGMVQTEAQYRFI
|...|. .|||||||..|  .||||..|.....   . ||||||||||.|||||||..|.|.. ....     .||.......|.|| |||||. ||||.
vthfhytnwpdhgvpdspellldflrlvrkala..sgggpvvVHCsaGvgRtgtfialdllleqleke...ggvdvleavkrlreqRpgmvqtpeqyrfv

YMAVQHYI
|.|. .|.
yealleyl
0045450 (Phosphotyrosine protein) phosphatases II 220-526 1.9e-102 338.3 In-house 2-304 (307) alignment 
Range on Protein: 220-526
Range on HMM: 2-304/307.0
RINAAEIESRVRELSKLAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFETKCN
...  ......  |. ..... . ..|...|||.|......||.........|||.|||||.|||.|||||.|.. |.. . ||||||. ... . . ..
dlplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllld

NSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVgqalLQGNTERTV
  . |. .|||||.|..||.|||||.......|||| |..||.|. ||..|||||   ..|| ..|....|.  ..||.| |...       . . .|||
gydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl....dgtgesrtv

WQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIY
...|. .|||||||...  .|||.|||.. .|.  . |||.||||||.|||||||....... ... |. .|.|........|.||.|.||.. ||||.|
thfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrfly

MAVQHYI
.|.....
eallell
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 221-538 5.2e-87 286.9 In-house 2-292 (318) alignment 
Range on Protein: 221-538
Range on HMM: 2-292/318.0
INAAEIESRVRELSKlaettdKVKQGFWEEFETLQQQECKLLYSRKegQRQENKNKNRYKNILPFDHTRVVLHDGdPNEPVSDYINANIImpefetkcNN
|.. ..||.||.| .      . .  . ||.| |...| .    .     . ||.|||| |||..||||| |..   .|. ||||||| |        . 
isvedleshvrrlre......sGelllseeyerlsrseetvtslks..lepvnkaknryanilaydhtrvkLqml.egeegsDyinanyi........dG

SKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYAlKEYGVMRVRNVKESAAHDYTLRELKLSKVGQallqgNTERTVW
 . ||.|||.|. | .|..||||||.. ||.|||| |.|.|||| |. .|||.. . ..|| ..|   .|    ||.|||.|... ..     . .|.| 
yrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgs.rsygklvvelkeevelsdyvlrefkvtrtee.....eesrqvr

QYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESiMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYM
|||. .|||.|||......||.. .|.. |..  .|||.|||||||.||||.||..|||.. |.. ..   .|| .|....|.||  ||||| || ||| 
qyhytsWpdegvpesgaslldlvrqvskaqqk.sgagpivvhCsaGvGrtGvfiavdillerikaeal...vDvfqtvkqlreqrnlmvqtedqyefiyd

AVQHYIETLQRRIEEEQK
... .... .  .. .. 
vllealasgdtevdasdl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 221-532 3.7e-78 257.8 In-house 5-296 (298) alignment 
Range on Protein: 221-532
Range on HMM: 5-296/298.0
INAAEIESRVRELSKLAETtdKVKQGFWEEFETLQQQECKLLYSR-KEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEpVSDYINANIIMpefetkcn
|.| ...  ...|..  ..  |   |. .||..|.. . ..     . ....|||.|||| .|...|..||||.. | .|  ||||||  .         
ieaedlkaalqklaavkkk..kkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedade.esdYiNAsflh........

NSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYAlKEYGVMRVRNVKESAAHDYTLRELKLSKVGQAllqgnTERTV
. | ....||||. |..||.|||||| .|.. .||| |. .| .| |. |||||| . ..|| ..|.  ..    |.. |.||.||  ..     .||.|
aykgrnafiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegk.etygeitvsllskeefadlivrklkvskkkee.....kerev

WQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESiMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIY
 | || .|||.|||.    |||.|..|. .|.      ||.|.||||.||.||||.|| ... .... |   .|| ......| .| |.||||.|| |||
rqlhftsWpdkgvpenatsvldllrkvrasqqq.agnkpvivqCsaGvgRsGtfiaidsvlervkkeqv...vDvfqvvkvlRkkrpgavqteeqYvfiy

MAVQHYIETLQRR
.||...... .  
eavlealdsfnde
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 223-536 1.4e-81 269.1 In-house 7-293 (319) alignment 
Range on Protein: 223-536
Range on HMM: 7-293/319.0
AAEIESRVRELSKlaettdKVKQGFWEEFETLQQQECKllySRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPnEPVSDYINANIImpefetkcNNSK
 .|...|...| .      . .... .||..|.. . .   . .. ...|||.||||.|||..|.||||| . |   . ||||||. |        .  .
vqeLkerlkalas......tgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldg.vegsdyinasfi........dgyq

PKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEyALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQgnteRTVWQY
 .. .||||. |.||..||||||..|.| ..|| || ||..| |. ||||.|   .||| . |   .|   .||  |.||| |  . .      |.| ..
erekfiatqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpee.nfeeyGrlivtleeeeeledyiirklklnkkssevet....Revkhf

HFRTWPDHGVPSDPGGVLDFLEEVHHKQESiMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV
..  ||||.|| .  ..||.|..... .|   ..||.|||||||.||||||||.|. .. ..| ||   .|| .|....| ||  |||...||.||| |.
qyteWpdhdvPekatslldllkrirksrek.tqsgPivvhCsaGvGRtGtfivldamlervkeegv...lDvfstvsrlRtqRnimvqrpeqYkfiyeal

QHYIETLQRRIEEE
 ...|. .  || .
leaveagdteievq
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 224-522 1.3e-68 226.7 In-house 14-287 (319) alignment 
Range on Protein: 224-522
Range on HMM: 14-287/319.0
AEIESRVRELSKLAETTDKvKQGFWEEFETLQQQECKLLySRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEpVSDYINANIImpefetkcNNSKP
 ...   ..||.  .  |. .. .. ||  . ..  .|   ..    ..||.|||. |||.||...| |.  .  |  ||||||  .        .  . 
pdfpayyqqlsnksdfddd.ltklevefrracklgvnla.dqtfanldqnkdknriinilafdknvvklerliGee.fsdyinasfv........tGyqr

KKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTkevergKSKCVKYWPDEYALKE-YGVMRVRNVKESAAhdYTLRELKLSKVGQAllqgNTERTVWQY
|. |||.|| |.||..|||||... |.  ||. |      | || .||| .   ||  . ..|  |.|.|   |..|...||. |.     .  | . |.
kdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetae..yvvrdielsedgke....kdirkitqf

HFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKgvdCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV
||. |||.|||  |  .. ... |.| ..   .  ..|||||||.||||..||.|.|.| ..|.     .|| .... .| ||. .||  .|| |||.|.
hflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysal
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 230-526 4.9e-80 263.7 In-house 6-279 (288) alignment 
Range on Protein: 230-526
Range on HMM: 6-279/288.0
VRELSKLAETTDKVKQGFWEEFETLQQQEckLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIImpefetkcNNSKPKKSYIA
.....| |..  . ..|| ||...| . |     | . |.. .|..||||.||||.|..|| |.... .|. .|||||. |        ...| || |||
ispvakvakksarnrtgfseeynsLaale..ktksvtagrlavnakknRyrnilpyDekrvklkkle.eeagaDYinasyi........dgekkkkkyia

TQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSkvgqallQGNTERTVWQYHFRTWPD
||| |..||||||..|.....  ||| |. ||.||.|| .||||.   |.|| . |  |..   .|..||.| |        . .||... ||.. .|||
tqgPladtvndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.......kkkteleitqyqylaWpd

HGVPSDPGGVLDFLEEVHHKQESimDAGPVVVHCSAGIGRTGTFIVIDILIDIIREkgvDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI
|||| .   .|..|. |.  ...  |.||..||||||.|||||||..| ||| ..|   .  |||  |.. .| ||  .|||. || ||| .. . |
hgvPeskapllellrqvkvanqa..dtgpiivhCsaGvGrtgtFialdalidavee...edyiDvagtvaklRkqRallvqtlkqYefiyevllsli
0043336 (Phosphotyrosine protein) phosphatases II 233-526 1.4e-87 288.9 In-house 8-277 (278) alignment 
Range on Protein: 233-526
Range on HMM: 8-277/278.0
LSKLAETTDKVKQGFWEEFETLQQQECkllYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDgDPNEPVSDYINANIImpefetkcNNSKPKKSYIATQG
|  |.|   ..|.....|||.|...     .... ....|||.|||||.|||.||.||.|.. ..... ||||||. .        .  . .. .|||||
lkallelllnlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsl.lggdldsdYinAsyv........dgynvprkfiatqg

CLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPdeYALKEYGVMRVRNVKESAAHDYTLRELKLSKvgqalLQGNTERTVWQYHFRTWPDHGV
.|..||.||||||.......||| |..||.|. ||..|||     ..|| ..|...||   .|||.| |....     |. . .|||..||.  ||||||
PlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeehlddytvrtlevtn.....lgdgesrtvthyhylgwpdhgv

PSDPGGVLDFLEEVHHKQEsiMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI
|...  .||||..|....|   . |||.||||||.|||||||....|.. ..  |    .|........|.|| |.|||. ||||.|.|...|.
peslsllldflkavreale..dsngpvlVHCsaGvgRTGtfialyllleqlekeg...gvdleeavkelreqRpgavqtpsqyrflyealleyl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 233-526 1.4e-52 173.6 In-house 7-279 (439) alignment 
Range on Protein: 233-526
Range on HMM: 7-279/439.0
LSKLAETTDKVKQG-FWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDgDPNEPVSDYINANIIMPEFEtkcnnskpKKSYIATQ
. .  |  || ||  | |.||...  . .         .. .. |||||.. .||||||.|..  |  | | ||||| |   ..        .| |||||
fqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqe.ipgvphshyinanyikGyyd........dklyiatq

GCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKskcvkYWPDEYALkEYGVMRVRNVKESAAHDYTLRELKLSkvgQALLQGNTERTVWQYHFRTWPDHG
|  ..|..||||.|.....  ||| |. ||  |     ||| .     || . ||  ..    .|..| .|.    .   ... |||| |.|. .|||. 
gpkkettddfwrlviekktvtivmltnlvesyk.....ywpsdaev.cygdiavrvdrnielpnyvirgfkvf...nerdttekertvlqfhyiawpdkn

VPSDPGGVLDFLEEVHHKQESiMDAGPVVVHCSAGIGRTGTFIVIDILIDIIRekgVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI
||..   |||||  .   ...  . ||||||||||.||||| | .|| .. ..   ..  .|.   ....| ||  |||. .|| ||| ||   |
vpaqashvldflrainsandk.eeygpvvvhcsagvGrtGtiialdialeqlk...lenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_PTPRG_pd Subfamily PTPRG 236-548 3.4e-76 251.6 In-house 10-310 (563) alignment 
Range on Protein: 236-548
Range on HMM: 10-310/563.0
LAETTDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPeFetkcnnsKPKKSYIATQGCLQ
.|.   . ..|| |||| ||..  .     .  |..|||.|||| ||...|..|| |..   ..   |||||| |.  .       . .| .||||| |.
vaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidG.y.......qkskafiatqgplk

NTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDeYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQG-NTERTVWQYHFRTWPDHGVPS
.|..|||||....|. .||| |. ||||. ||  |||     ..||...|. ..|     || |.|.. ..     .  .||..| |||. .|||||||.
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

DPGGVLDFLEEVhhKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIE
 .  || | .    ..    .|||.|||||||.|||||.||.| |.  |... .   ..| ......|.||  .|||| || |.. |..  | . .  . 
hslpvLifvkks..saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqena...vnvfgflkhiraqRnflvqteEqYiflhdalleaiasketell

EEQKSK-RKGHEYTN
.||  . ..   | .
aeqveelknctpyle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 236-528 7.6e-75 246.6 In-house 6-278 (281) alignment 
Range on Protein: 236-528
Range on HMM: 6-278/281.0
LAETTDKVKQGFWEEFETLQQQECKllYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQ
|...... ..|| ||.|.|.. . .   . .  ...||..||||.||  .|.|||.... . ..  .|||||| .        .  | .| |||||| . 
lkqlsqndnaGfieeyeklaaigvd..ntataskadenvlknrYsnivaYDatrvkvtpne.enkntDYinanfv........pgykgekeyiatqgPvP

NTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKvgqallQGNTERTVWQYHFRTWPDHGVPSD
.....||.||.... ..||| |.|.| || || .||||. .  .|| ..|....|.. . |  |..||..      ... .|.| | .. .|||||||..
aslvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkler......esgetreveqlaytaWPdhGvPat

PGGVLDFLEEVHHKQESIMDaGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIET
.  .|.| .||.. .|.  .  |.|.|||||.|||||.| .| |.. . ..    ..||  ... .| .|  |||| .||.|.| || .... 
tkellefrkevlkltekktk.aplvihCsaGvGrtGtyialDrlvkaveaele..eldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 237-522 1.7e-62 206.2 In-house 16-275 (315) alignment 
Range on Protein: 237-522
Range on HMM: 16-275/315.0
AETTDKVKQGFWEEFETLQQQECKLLysrKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIImPEFETkcnnskpKKSYIATQGCLQN
|.     |.|| ...|..   . . |   .  .. |||.|||| ||...|..|| |   . |.| |||.||| | . ..        |. |||.|| . .
aqkkastkngfkqdyesipggqlhpl...dvakkienkqknryiniiaydksrvqlplle.ndphsdyvnanfi.dGynk.......krryiaaqgpnva

TVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEyaLKEYGVMRVRNVKESAAHDYTLRELklskvgqALLQGNTERTVWQYHFRTWPDHGVPSDP
.|.||||.||.|.   ||| |. ||. |.|. |||||.     || . |  ..|    .|| | |       .   |.  |.| |.|. .||| |||   
svkdfwrlvfeedigkivmltnlvegekrkaekywpdk..kviyGkitvtrkseevnteytvrtl.......svvfgdnirevvqlhytswpdmgvpkyt

GGVLDFLEEVHHKQESIMdaGPVVVHCSAGIGRTGTFIVIDILIDIIRekgVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV
  ....   |.  ... .  |..|||||||.||||||| .| ..| .    ..  ||| . |. ||..| .|||. .||.||| |.
iplmnlirtvkqhhtnsv..gaivvhcsaGvGrtGtfitldavldqae...aenaidvynfitgvrqnrikmvqvaeqyqfiydal
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 237-530 1.2e-61 203.2 In-house 12-287 (290) alignment 
Range on Protein: 237-530
Range on HMM: 12-287/290.0
AETTDKVKQGFWEEFETLQQQECKllYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDG-DPNEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQ
|. . | ..|| ..|..|.. | .  .. . |  ..||..||..||.. |  |..|..  . ..   .||||  |        .. | ||.|||||| ..
anghakgnegfrnqfkmldsgese..htvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyi........kgykekkqyiatqgpvs

NTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEyALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQAllqgNTERTVWQYHFRTWPDHGVPSD
||. |||... ||.. .||| |...| || || .||||.   |.|| .... ..|.. ..|. |.|.. .  .|    .....| ||.. .|...|   .
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpds.dtkaygefsikllneetlneyierklevknknsa....gakqsvtqyqitnwdstgkvtn

PGGVLDFLEEVHHKQESIMdAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQ
| ..|  .||. ..|      ...|||||...||...|..... |.  . .||   ||| . ..  |.|. |.|||. ||..|.  | .|.....
pqtillvieemyktqrkrg.ntsivvHCSdtvgrsavfcaaattinkcktegv...idvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfe
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 237-531 3.6e-59 195.1 In-house 12-283 (287) alignment 
Range on Protein: 237-531
Range on HMM: 12-283/287.0
AETTDKVKQGFWEEFETLQQQECKLlYSRKEGQRQENKNKNRYKNILPFDHTRVVLHdgdpnEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQN
|. ..| ..|| . | .|.| . .   .   .  ..||.|||...||. |  ||.|.     .   |||||  |        .  | || .|.... . |
akghakgnegfknqftvleqvtqre.devthniasqnkdknRltqilvpdnyrvllk.....gehpdyinavfi........dgykekkafiiaesPmfn

TVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYAlKEYGVMRVRNVKESAAHDYTLRELKLSKVGQAllqgNTERTVWQYHFRTWPDHGVPSDP
|. .||... ..|  .||| ..| |  ...| .|||.| .   .|  ... ..|   ..|. |.|.. . ..|    .....| ||.. .|...|  ..|
tarnfWkliddrnvtaivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevknknka....gdkqqvkqyqitnWdstgkvtep

GGVLDFLEEVHHKQEsIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQR
  .|  .||  ..|      ...|||||...||...|. ... |.  .. ||   ||| . ..  | |. |.||| .||.||. .|..|... . 
qtillvieemyktqr.krgntsivvhCsdtvGrsamfcaaattinkckteGv...iDvfqvlksqriqkpgsvqtveqykfindivleyldsfet
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 237-529 3.2e-43 142.6 In-house 14-290 (305) alignment 
Range on Protein: 237-529
Range on HMM: 14-290/305.0
AETTDKVKQGFWEEFETLQQQ-ECKLLYSRKEGQrqeNKNKNRYKNILPFDHTRVVLHDGDPNepvsDYINANIImpefETKCNnskPkKSYIATQGCLQ
 .| .|. .|. .|| ....  . . . . || |   ...|||||..  .|. || |.   |     .|| || .     | .|   | | .| ||  |.
krtlekgpaglraefvamkrfndfekmkafkeaq...eagknrykdvgcldnnrvklegpwph....eyihanyv....stptn...p.krfictqaple

NTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDE----YALKEYGvmRVRNVKESAAHDYTLRELKLSKVGQALL----QGNTERTVWQYHFRTW
.|  ||| | .|..   | |  . .|.|  ||..|.. .      ..| |  .   ||  ... . .|.   .|| .. |     |.. | | .||.  |
ktcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekg..qkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidw

PDHGVPSDPGGVLDFLEEVHHKQesimdaGPVVVHCSAGIGRTGTFIVIDILIDIIREkGVDCDiDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIE
|| |||.    .|..||.    .      ||.||||||||||||. .... ..| . . |   . |  | .| .| ||   .||.||| |..  .  |..
pdrgvpaadlailellekarpsk......gpivvhcsagigrtgsvvmleyildqlla.gqiie.dtdkilqkireqrnnsiqtdaqylfvhqvilnyfr

TL
  
kk
subfamily_Ptp69D_pd Subfamily Ptp69D 238-528 1.3e-74 246.1 In-house 15-288 (307) alignment 
Range on Protein: 238-528
Range on HMM: 15-288/307.0
ETTDKVKQGFWEEFETLQQQecKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNT
    . ..|. .|.|.|...  .   | | ....||. ||||..| .||.|||.|.     .  ||||||. |        .  | ||..|| |. ...|
srkrdtdfglakeyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkin.gkedsdYinasfi........kgykekkkfiaaqdPveat

VNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEyALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDPG
..|||||. . .. .||| ... |  . || ||||.|   ..|| . |. |.|. ..||. |||..||...   . . .| | |||. .|.|  ||  . 
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevar

GVLDFLEEVHHKQE-SimdAGPVVVHCSAGIGRTGTFIVIDILIDIIREKgvdCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIET
|.|...|.|.. .. .    .|.||||||| ||.|.|. .|.|.. ...      .|. .|.. .||||. .||  .|| |.| |.  |.. 
gllklieqvrelykln...rsPivvhCsaGvgrsgifvaldsllqqlkae...dkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 238-534 3.6e-72 238.1 In-house 15-291 (305) alignment 
Range on Protein: 238-534
Range on HMM: 15-291/305.0
ETTDKVKQGFWEEFETLQQQECKLlysrKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEpVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNT
|.. . ..|. .....|...| ..    . |....||.|||.|.| ..|. |. |   . ..  ||||||. .        .  | ||.||..|| |.||
earvysdkgleaqykslyeeeesi....dvgkkeankaknrlkeitlldddriiltekesld.dsdyinasyv........dgykrkkkyivaqgPlknt

VNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYAL-KEYGVMRVRNVKESAAHDYTLRELKLSKVGQallqGNTERTVWQYHFRTWPDHGVPSDP
|.||||....|  ..||| || || ||.|| .|||.. .  ||.| . |    |..| ||. |.||.|.  .     . .||| ||.. .|||||||  .
vadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede....dkesrtvlqyqltdWPdhGvpqfa

GGVLDFLEEVHHKQESimDA-GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIE
. .|.....|...|..  |   |..||||||.||||.||..|| .. ... .|   .|| . .. .||.| .|||| .|| |.. |.. .|.. .  | 
tsllslikrvqkdqkk..dkgvpllVhCsagvgRtGvfiavdialerlkkEev...vdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsii
subfamily_PTPRB_pd Subfamily PTPRB 239-528 1.9e-84 278.2 In-house 19-287 (293) alignment 
Range on Protein: 239-528
Range on HMM: 19-287/293.0
TTDKVKQGFWEEFETLQQQECKLlySRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIImPEFETkcnnskpKKSYIATQGCLQNTV
.. . . .| ||.|.|.. . .   . |  ....|..||||.||||.||.|| |.. . .|. ||||||| | |....       .. .||||| | .||
mkadsdlrfseeyeelkavgkdq..avkaaelavnraknrytnilpydhsrvkLaalk.desgsDYinanyi.pgyns.......prefiatqGPlpetv

NDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKvgqallqGNTERTVWQYHFRTWPDHGVPSDPGG
.||||||....|..||| |. ||.|| || .|||...    || ..|  |.|.  .|...||||..|       ...||.| |||| .|||||||...  
ddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.......ekeerkvrqyhftsWpdhgvPektkt

VLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIET
.|||...|....|. ....|.|||||||.||||||| .| |.. |.|. .   .|.  ... .|..|  .||||.|| ||. .|......
lldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedy...vdifgivaelReeRnllvqtekqYifihqcvldllrk
subfamily_PTPRA_pd Subfamily PTPRA 239-526 1.6e-80 265.5 In-house 27-295 (330) alignment 
Range on Protein: 239-526
Range on HMM: 27-295/330.0
TTDKVKQgFWEEFETLQQqeCKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTV
..|  |. | |||..|    ...  . .  ...|||.|||. ||||.|..||.|   .  .. ||||||  |        .  | |...||.|| ...||
saddnkl.freefnalPa..gpiqatlelaskeenkeknrvvnilPydfsrvilsvke.Gveesdyinasfi........dGykekdkfiaaqGPkeetv

NDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYAlKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALlQGNTERTVWQYHFRTWPDHGVPSDPGG
.|||||... .|  ||| |.  || ..|| .||||| .   || .||   .|  . |||.|.. . ....|  . ...| | |.||..||| |||..| |
edfwrmiweqksativmltelkerkeekcaqywPdeGl.vtyGnirvevedetvlvdytvrkflvqqlpdat.rekksrlvrqfhftswPdvGvPfepiG

VLDFLEEVHHKQESimDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI
.|..|..|.....    |||.|||||||.||||||||.| ... .. ...   .|| .... .| ||. ||||. || ||| ....| 
mlkllkkvkklnqq..sagpivvhcsaGvGrtGtfivldavlervkaerk...vdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy
subfamily_PTPN9_pd Subfamily PTPN9 239-527 7.1e-73 240.2 In-house 10-291 (297) alignment 
Range on Protein: 239-527
Range on HMM: 10-291/297.0
TTDKVKQGFWEEFETLQQQECKLLYSRKegQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIimpefetkCNNSKPKKSYIATQGCLQNTV
  .| |.|  .|.. ..... .  . .   . . | .||||...| .|.|||||   | ... |||||||         ..  | ||..||||| |..||
vkekgkrGlskeyaeirnepveGtflas..klranleknrytdvlcydetrvvlakvd.edeasdyinanf........vdGykqkkafiatqGplkktv

NDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWP-DEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVgqallQGNTERTVWQYHFRTWPDHGVPSDPG
.||||||.... .||||||. ||||. || .||| .| . .|.| ..|.||.    .||. | |....|     . . .|.|  . | .|||.||||.  
sdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknv.....kteesrkvthfqflsWPdyGvPssaa

GVLDFLEEVHHKQESIMD-----------AGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI
 .||.||.| .|| ....             |.||||||||||||||| .|| .. ..|.|.   .|| .|....|.||. ..||. || | |.||  | 
slldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgt...vdvvetvkllrtqrafsiqtpeqyefcylavleya

E
 
l
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 239-532 3.4e-44 146.1 In-house 10-283 (307) alignment 
Range on Protein: 239-532
Range on HMM: 10-283/307.0
TTDKVKQGFWEEFETLQQQECKLLYSrkeGQRQENKNKNRYKNILPFDHTRVVLHDgdpNEPVSDYINANIImpefetkCNNSKPKKsYIATQGCLQNTV
| ||  | . .||. | ... . .        . | .||||...   |..|.|..    .   |||| || .           |||| .|..|| |.||.
tldkgvqalvdefrvlakktpegvtv...eafsantdknryqdvkcqdkgrivvkf...dglasdyihanyl.......giaikpkk.ficaqgplentq

NDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMR--VRNVKESAAHDYTLRELKLSKVGQALLQGNTERTVWQYHFRTWPDHGVPSDP
 .|| |. ||.   ..|  | .| .| || .||| |   |   . .    .|..  |.  .  |  .      .  ..  ||. .. .  |||.|||   
ysfwamaiqekvesvimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqin

GGVLDFLEEVHHKQEsimdagPVVVHCSAGIGRTGTFIVIDILIDIIReKGVDCdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRR
 . ...|| |. ...      |||||||||.||.|| . | .. | .  .|..|  |. | .. .||||   .|||||| ...  . .|   | . 
ltainlleavrydtn......pvvvhcsaGvGrsGtivaislvqdkmi.aGinc.kdmkklveelrsqrhyaiqteaqylylhrvlleyflelyke
subfamily_ptpA1_pd Subfamily ptpA1 239-480 6e-40 132.2 In-house 19-253 (418) alignment 
Range on Protein: 239-480
Range on HMM: 19-253/418.0
TTDKVKqgfwEEFETLQQQECKllYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEpVSDYINANIImpefetkcNNSKPkKSYIATQGCLQNTV
   |.|    |||  |..          ||... | .|||| |||| .|||| |.  . .|  ||||||| |        . . | | .|.||| | ||.
cihkik....eefrlleesvgp..setsegdkkhntsknrytnilpvnhtrvqlkkiqdke.gsdyinanyi........dgayp.kqfictqgplpnti

NDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRN-------VKESAAHDYTLRELKLSKVgQALLQGNTeRTVWQYHFRTWPDHG
 ||||||...  |.||| ..| |  . || .|||..   ... .    |       |.     .   ||.   .. .  ..|.| | . ||..  |||| 
adfwrmvwenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrni.rltfeget.rditqyqyegwpdhn

VPSDPGGVLDFLEEVHHKQESIMDA----GPVVVHCSAGIGRTGTFIVIDILI
.|     . ..|  .  .|. |. .     |..||||||.||||||    |..
ipdhtqpfrqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimm
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 239-311 8.3e-07 23.1 In-house 17-82 (95) alignment 
Range on Protein: 239-311
Range on HMM: 17-82/95.0
TTDKVKQGFWEEFETLQQQECKlLYsrKEGQRQENKNKNRYKNILPFDHTRVVLHDgdpnEPVSDYINANIIM
   .  | | .|| ...       |    |  . |  |||. ||.|.| |||||         |||||| .. 
mhsnsdqefdnefksismtsga.py..tvgsseanipknrflnifpydatrvvltt....krdsdyinacfvd
subfamily_PTPRD_pd Subfamily PTPRD 240-538 1.8e-96 319.0 In-house 18-293 (564) alignment 
Range on Protein: 240-538
Range on HMM: 18-293/564.0
TDKVKQGFWEEFETLQQQeckLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNePVSDYINANIImPEFETkcnnskpKKSYIATQGCLQNTVN
  . .. | ||.......      . .. . ..||.||||.||...||.||||.  . . . ||||||. |   ...       .|.|||||| |..|..
kansdlkfeeeykkieeg...qqftweaankpaNkaKNRyanivaYdhsRVvLskvegd.egsDYINAsfi.dgyrk.......rkayIAtqgPlaetie

DFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEyALKEYGVMRVRNVKESAAHDYTLRELKLSKVGqallqGNTERTVWQYHFRTWPDHGVPSDPGGV
||||||...||..||| || .|.|| || ||||..   ..|| . |  ..|    ||..|..||.|        .  |.| |.||  |||||||  . ..
dFWRmvweqnsstiVmltkleEkgkvkchkYWPek.gtetygeltVtleeeeeladyeirtfklkkkk.....ssesreVrqFhFtsWPdhgvpesatsl

LDFLEEVHHKQEsiMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREkgvDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQK
||....|.. .|   ||||.|||||||.||||||||||.... |.|   . ..|. ......|.||  ||||| || ||. |......  .  .| |. 
Ldlirkvralne..pdagPivVhCSaGVGRTGtfividamlerike...ektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenl
subfamily_PTPN23_pd Subfamily PTPN23 240-529 1.4e-60 199.5 In-house 10-283 (288) alignment 
Range on Protein: 240-529
Range on HMM: 10-283/288.0
TDKVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHdgdpnEPVSDYINANIImPEFETKCnnskPKksYIATQGCLQNTVN
. . | .. ..|. |.|.. |   .|     . . .|||...|||.||.||.|.     .   |||||  .  .  . |    |.  .||||. ||.|.|
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr.....gskDDYinAsfv.kdlspgc....Pd..fiatqaPlqstln

DFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEY-ALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQallqgNTERTVWQYHFRTWPDHGVPSDPGG
|||.||... |.|||| ... |.|| |. .||| .  . ...| ..|   ..  .. .  |.|||.  ..     .. ..|   .. .||..|||. |. 
DFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletlda.....davksvshlqltsWpelGvPasPet

VLDFLEEVHH--KQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIrEKGvDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL
.|.||.||..  ...      |.|||||||.||||.| ..   .  . ||| .  .|... .. .| ||  |||...|..| | || ....  
llqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrel.ekg.nglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrv
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 240-527 2.2e-52 172.6 In-house 10-294 (301) alignment 
Range on Protein: 240-527
Range on HMM: 10-294/301.0
TDKVKQGFWEEFETLQQQECKllySRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDP-NEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTV
. | ...| |....|...| |   | . | ..|||. ||.||| ..|. |..|.     .    .||||. |        .. . || .||.|| ...|.
aakhsnkfeeqykelkegedk...sctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyi........dgysekkkfiaaqgpmkktl

NDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPD-EYALKEYGVMRVRNVKESAAHDYTLRELKLSkVGQAL--------L---QGNTERTVWQYHFRT
 ||||...||    ||| |.. |. |||| .|||. |   .|.| . |  |.| .  |...|.|..  . ..         .   . .. ..| |..   
vdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvk.iqdgsnngyierkfkvksdksswdvlqlqvtd

WPDHGVPSDPGGVLDFLEEVHHKQESImDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI
||..||  .|  ||  ...| |.| .| . ||||||||....|.|... ..| ..  .  ||   .|| . .. || .. |.|.|  || .|| ... |.
WpqdGvvreprtvLqviddvihrqqki.gggpvvVHCSdtVsrsGvYcsvsiglEQckaegV...VdvfqvtkavrrskpgaVtTLeqytsiydvidmyl

E
.
q
0040438 (Phosphotyrosine protein) phosphatases II 242-534 6.5e-93 306.7 In-house 15-284 (317) alignment 
Range on Protein: 242-534
Range on HMM: 15-284/317.0
KVKQGFWEEFETLQQQeckL-LySRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPnEPVSDYINANIImpefetKCNNSKPKksYIATQGCLQNTVND
. .....||||.|...       ........|||.||||..|||.||.||.|.. ..  . ||||||. .      .. | |.|  .|||||.|.|||.|
sdftalleefedllsl...kld.tysvaelpenkdknrypdilpydhsRVkLsplgg.dldsdYInAsyv......dgpnlkrk..fIatqgPlpntved

FWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDeYALKEYGVMRVRNVKESAAHDYTLRELKLSKVgqallQGNTERTVWQYHFRTWPDHGVPSDPGGVL
|||||......|||| |...|.|. || .|||.    ..|| ..|....|   ...|||.|....      .....|||...|. .|||||||..|  .|
FwrmvweqgvtvivmLteleelgrekcaqYwpl.getltygdftvtllseeelagitlrtlevedl.....gdsesrtvthfhytgWpdhgvppspdlll

DFLEEVHHKQEsimD-AGPVVVHCSAGIGRTGTFIVIDILIDIIREKGvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIE
||||.|....|   |  |||.||||||.|||||||....... ....|   ..||.......|.||.|.|||..||||.|.|...|. .   ...
dfleavreale...dpggpvlVHCsaGvgRtGtfiaaylmleqlekeg...gvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlep
subfamily_PTPN12_pd Subfamily PTPN12 242-536 5.5e-82 269.9 In-house 5-287 (290) alignment 
Range on Protein: 242-536
Range on HMM: 5-287/290.0
KVKQGFWEEFETLQQQECKL----LYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEpVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNT
. .. | .||..|.... |.     ||...|...||..|||||.|||.|..||.|.  . .|  |||||||.|        .... |..|||.|| | .|
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeee.gsdYinanfi........kgvegkleyiaaqgPLpkt

VNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKE-YGVMRVRNVKESAAH-DYTLRELKLSKVgqallqgNTERTVWQYHFRTWPDHGVPSD
..|||||... | ...||  .||| || || .|||.|   .  .| ..| . .| | . |...| ||. .        ...|.| |.|.. |||||||| 
lddfWrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq.......kesrkvyqfhYtaWPDhgvPss

PGGVLDFLEEVHHKQEsiMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEE
.  .|...|.|.. ||   .. |.|||||||.||||| |.||.  ...... .. ..|| . .. .| ||. .|||. ||...|.|| .....  . |||
aksllelielvrelqe..sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleiiee

E
.
k
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 242-528 3.9e-54 178.4 In-house 7-279 (287) alignment 
Range on Protein: 242-528
Range on HMM: 7-279/287.0
KVKQGFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGdPnEPVSDYINANIImPEFETkcnnskpKKSYIATQGCLQNTVNDF
.||.   .|...|..      .  |. .   . .|||| ..||.|.|||.|    . |  ||||||| . . ..        ....||.|| .  ||.||
rvkddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsae.g.elGsdyinanyv.asytd.......deafiaaqgPiaatvrdf

WRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNV-KESAAHDYTLRELKLSKvgqalLQGNTERTVWQYHFRTWPDHGVPSDPGGVL
||.|....| .... |.||| .. || ||||.       |   |  . ..    .|. | |.| .     |...  | | |... .|||....    |..
wravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlid.....letrearvvkqldllswPdkvlaPtavgli

DFLEEVH---HKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIET
 |  .|.     . .  ..||.|||...||||.|... . .|..   . |    .|| ...  .| .| ..||.  |.|..| |.  | .|
rfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlG...rvdvaavvirlreyraalvqavvqlrllyealvtyykt
0036941 (Phosphotyrosine protein) phosphatases II 243-529 1e-95 315.8 In-house 11-280 (297) alignment 
Range on Protein: 243-529
Range on HMM: 11-280/297.0
VKQGFWEEFETLqqQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLhdgdpNEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFW
 ......|||.|  ....||.|.. ....||..|||||.|||.|||||.|     ... ||||||. .        .  . |. .|||||.|.|||.|||
flalllkefeel..lpllllgslsvallpenleknRykdilpydhtRVkl.....ddegsdYinAsyv........dgydlkrkfIatqgPlpntvedFW

RMVFQENSRVIVMTTKEVERGKSKCVKYWPDE-YALKEYGVMRVRNVKESA--AHDYTLRELKLSKVgqallQGNTERTVWQYHFRTWPDHGVPSDPGGV
|||...|..|||| |..||.|. || .|||.|    ..|| ..|......     |||||.|.....     ... .|||...|. .|||||||..|  .
rmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt.....gngesrtvthfhytgwpdhgvpespasl

LDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL
|||.|.|..... ... |||.||||||.||.||||..|.... ...|   . .|........|.|| |.|||. ||||.|.|..... . 
ldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkk
0047943 (Phosphotyrosine protein) phosphatases II 243-526 3.4e-93 307.3 In-house 10-272 (273) alignment 
Range on Protein: 243-526
Range on HMM: 10-272/273.0
VKQGFWEEFETLqqQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLhdgdpNEPVSDYINANIImpefetKCNNSKPKksYIATQGCLQNTVNDFW
 .....||||.|  ...| |.... ....|||.|||||.|||.||.||.|     ... ||||||. .      .. |.|.|  .||||| |.|||.|||
gltllleefell..lslkplltysvallpenkdknrykdilpydhsrvkl.....gdggsdyinAsyv......dgynlkrk..fiatqgPlpntvedfw

RMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYA--LKEYGVMRVRNVKESAAHDYTLRELKLSKVGqallqGNTERTVWQYHFRTWPDHGVPSDPGGVL
|||...|.||||| |..||.|. || .|||.|     ..|| ..|....|   .|||.|.|.|...|      . .|||...|. .|||||||...  .|
rmvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg.....tgesrtvthfhytgwpdhgvppslesll

DFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI
.|.|.|....|.... ||||||||||.|||||||..|.|.| ....|    .||.......|||| |||||. ||||.|.|. .|.
efielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeg...gvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 243-526 3.7e-59 195.5 In-house 21-288 (325) alignment 
Range on Protein: 243-526
Range on HMM: 21-288/325.0
VKQGFWEEFETLQQQECKllySRKEGQRQENKNKNRYKNILPFDHTRVVLHDgDPNEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFW
 ..||  ||. |  .. .   ..|   . |||.|||.||....|..||||     ..| ||||||. .        .. | |. ..|.|  | .|.||.|
dqdgfahefgllpsddgi...akkvamkpenkaknrfknvvaldksrvvlet.kkddpssdyinasyl........rddkkkdvflaaqaPltatindlW

RMVFQENSRVIVMTtKEVERGKSKCVKYWPDE-YALKEYGVMRVRNVKESAAHDYTLRELKLSKVGqallQGNTeRTVWQYHFRTWPDHGVPSDPGGVLD
|.|.. .. |.|..  |.. || .| .|||.|    |..| ..|. .      ||  | |.. .|     .|.| |.| |.....|.| ||.  |  .. 
rlvldWrcsvvvvl.neldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvk....kGet.rsvkqfqlqswddmGvqkrpatlis

FLEEVHHKQESIMD----AGPVVVHCSAGIGRTGTFIVIDILIDIIREkgvDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI
.|. |.. .| .      ..|..||||||.||||.|| .  ... . |   .  .|. . .. .| .|  ||.|  || .|| |.  ..
ilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvie...esrvdifgfvkklrkdrpsmvetvdqyiliyealveay
0039614 (Phosphotyrosine protein) phosphatases II 244-527 3.9e-90 297.6 In-house 31-290 (297) alignment 
Range on Protein: 244-527
Range on HMM: 31-290/297.0
KQGFWEEFETLQQQECkllySRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIImpefetkcNNSKP-KKSYIATQGCLQNTVNDFW
|.....|||.|... .    ........|||.|||||.|||.||.||.|.. |   . ||||||. .        .  .  .. .|||||.|..||.|||
ktllllefeellslkp....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv........dgydlltrkfIatqgPlpetvedFw

RMVFQENSRVIVMTTKEVERGKsKCVKYWPDEYAlkEYGVMRVRNVKESAAHDYTLRELKLSKvgqallqGNTERTVWQYHFRTWPDHGVPSDPGGVLDF
|||......|||| ||.||.|. ||..|||.|    .|| ..|...|.   ..||.|.|....       .. .|||.....  |||||||...  .|.|
rmvweqgvtvivmLtklvelgr.kcaqywpeegg..tygdftvtllkvehldgytvrtlevtn.......ngesrtvthfqytgwpdhgvppslelllef

LEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKgvdCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIE
||.|.. ...  . |||.||||||.|||||||....... ....   ...||.......|.||.|.|||. ||||.|.|..... 
lelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke...ggvdvleavkelreqRpgavqtpsqyrflydallellk
subfamily_PTPRK_pd Subfamily PTPRK 244-522 6.9e-74 243.5 In-house 21-273 (314) alignment 
Range on Protein: 244-522
Range on HMM: 21-273/314.0
KQGFWEEFETLQQQeckllysRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFWR
  || ||.|.| .            ...||..|||...||..|..||.|.  | ..| ||||||..|        .  |  . .|.||| ||.||.||||
gygfkeeyeslfeg.......wdaakkdenreknrsgdilaydrsrvflitid.gdpssdyinaali........dsykrpaafivtqgPlqetvkdfWr

MVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALkeYGVMRVRNVKESAAHDYTLRELKLSKVGQALlqgNTERTVWQYHFRTWPDHGVPSDPGGVLDFL
.|..||.  ||| |. || |. ||.||||..     || ..|  |. ..  ..  | ....|. ..    .  |.| |..| .||||.||    |.|...
lvydencasivmltelvevgrvkClkyWPedtev..ygdikvelvetellaelvvrifrveklargq...eeirevrqfqflgWpdhdvPvsatgllklv

EEVHHKQESimDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV
 .|...||   .||..||||||| |||||||.|||..|.|...||   .|| .... .||... ||.|| ||.||| ..
rrvkksqee..eaGrivvhCsaGaGrtGtfiaidivldmieregv...vdvfnavktlrsrkvnmveteeqykfiydvi
subfamily_PTPN1_pd Subfamily PTPN1 244-537 4.3e-72 237.3 In-house 4-282 (290) alignment 
Range on Protein: 244-537
Range on HMM: 4-282/290.0
KQGFWEEFETLQQQECKlLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPnepvsDYINANIImpEFEtkcnnsKPKKSYIATQGCLQNTVNDFWR
|. ...|. .  ..|..  .. .| ...||.|.|||... |.||.|..|...|      |||||...  |.|      . |.||| ||| | |||. ||.
kkrlykeiyldirkeas.dfptreaklpenrnlnryrdvspydhsrikleradn.....dyinaslv..ele......eakrsyiltqGPlpntvdhfWq

MVFQENSRVIVMTTKEVERGKSKCVKYWPDEYA---L-KEYGVMRVRNVKESAAHDYTLRELKLSKvgqalLQGNTERTVWQYHFRTWPDHGVPSDPGGV
||....|. .||  | ||... ||..||| .     |  |   ..|. ..|   . ||.| |.| .     |. .  |.. ..|. |||| |||. |.  
mvWeqkskavvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen.....lktqetreilhfhyttwpdfgvpespaaf

LDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQ
|.|| .| .      | ||.|.||||||||.|||...| ..  | .|.    .|. |..  .|..| |..||  | || |.|. . . ....    ..
lkflfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssvqk
0046845 (Phosphotyrosine protein) phosphatases II 246-529 1.1e-100 332.0 In-house 1-277 (284) alignment 
Range on Protein: 246-529
Range on HMM: 1-277/284.0
GFWEEFETLQQQECKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIImpefeT--KCNNSKPKKSYIATQGCLQNTVNDFWR
|..||||.|... .|||.|.. ....||..|||||.|||.||.||.|.  |.. . ||||||. .     .   .. .. || .||||| |.|||.||||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyv.....dgydldltyikkkfIatqgPlpntvedFwr

MVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQallqGNTERTVWQYHFRTWPDHGVPSDPGGVLDFL
||...|.||||| |..||.|. || .|||.|   ..|| ..|....|   .|||.|.|.|...|     .. .|||...|. .|||||||..|  .|.||
mvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy....tgesrtvthfhytswpdhgvppspedllefl

EEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL
..|.. .|.. . ||.|||||||.|||||||..|.|.. ....| .. .||.......|.|| |||||..||||.|.|...|. ..
rlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 246-524 1e-49 164.0 In-house 21-234 (392) alignment 
Range on Protein: 246-524
Range on HMM: 21-234/392.0
GFWEEFETLQQQEcklLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIImPEFETkcnnskpKKSYIATQGCLQNTVNDFWRMV
 | |||  | . .   .| .. .|.. |..|||||||||.| .||.|   | . | |||.||  | | |..       .|.|||.||    ...||||||
lffeefhdlpgpd...iypqtvaqkeinlkknryknilpydsarvklevid.dipdsdylnasyi.psfdn.......ekayiasqgpnaaslddfwrmv

FQENSRVIVMTTKEVERGkskcvkywpdeyalkeygvmrvrnvkesaahdytlrelklskvgqallQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEE
||||   |.| ||  |                                                  .|.  ||| |.||  |||..||     .| |..|
fqenvttiamvtklkegd................................................kgddartvaqfhftewPdkdvpkhtssllkfike

VHHKQESImdAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQH
|. .  .   . |...|||||.||||  | || ..   ..  .   .|| . .  .| .|  ||||. || ||| ||  
vkadfGqy..thpliihcsagvgrtgvvisidsvvahakktrm...vdvfnfvtnirrkrpymvqtkeqyafiygavle
DSPc_SM00195 247-526 6.9e-92 302.8 In-house 2-262 (263) alignment 
Range on Protein: 247-526
Range on HMM: 2-262/263.0
FWEEFETLQQQECKLlySRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNePVSDYINANIIMPEfetkcnnsKPKKSYIATQGCLQNTVNDFWRMVF
..||||.|.... .   . .|.....||.|||||||||.||||| |.. . . . |||||||.|  .        ..||.||||||.|..||.||||||.
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga........nkkkkyIatQgPlpstvedFWrmvw

QENSRVIVMTTKEVERGKSKCVKYWPDEY-ALKEYGVMRVRNVKESAAH-DYTLRELKLSKVGQallqgNTERTVWQYHFRTWPDHGVPSDPGGVLDFLE
.|....|||.|.|.|.|| || .|||.|    ...| ..| .|..     ...||.|.|.| |.     ...|.| ||....|||||||...  ||..|.
eekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.....eetrkvtqyqyknWpdhgvpdstksvlellr

EVHHKQESImdAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI
.|.......   ||.|||||||.||||||..|||... ..|.     .|. ......|.|| |||||..||.|||.|. .||
avkksksts..sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 247-526 6.9e-92 302.8 In-house 2-262 (263) alignment 
Range on Protein: 247-526
Range on HMM: 2-262/263.0
FWEEFETLQQQECKLlySRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNePVSDYINANIIMPEfetkcnnsKPKKSYIATQGCLQNTVNDFWRMVF
..||||.|.... .   . .|.....||.|||||||||.||||| |.. . . . |||||||.|  .        ..||.||||||.|..||.||||||.
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk.egsdYINAnyikga........nkkkkyIatQgPlpstvedFWrmvw

QENSRVIVMTTKEVERGKSKCVKYWPDEY-ALKEYGVMRVRNVKESAAH-DYTLRELKLSKVGQallqgNTERTVWQYHFRTWPDHGVPSDPGGVLDFLE
.|....|||.|.|.|.|| || .|||.|    ...| ..| .|..     ...||.|.|.| |.     ...|.| ||....|||||||...  ||..|.
eekvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk.....eetrkvtqyqyknWpdhgvpdstksvlellr

EVHHKQESImdAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI
.|.......   ||.|||||||.||||||..|||... ..|.     .|. ......|.|| |||||..||.|||.|. .||
avkksksts..sgpivVhCsaGvgRtgtfvtidiilskleeekk...vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN13_pd Subfamily PTPN13 247-529 1.2e-73 242.8 In-house 13-272 (273) alignment 
Range on Protein: 247-529
Range on HMM: 13-272/273.0
FWEEFETLQQqeCKLLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPnepvsdYINANIIMPEFetkcnnSKPKKSYIATQGCLQNTVNDFWRMVF
  |||..|..   | | . ..|...|||.||||.|.||.|.||| | |  .      ||||. |  .        | . .|||.|| | .||.|||.||.
Paeefkelre..lkpldtcevgkkkenkdknryrnvlPydetrvklgdegg......yinaslikvpv......gkdeyeyiacqGPlPetvkdfwqmvw

QENSRVIVMTTKEVERGKSKCVKYWPDEY--ALKEYGVMRVRNVKESAAHDYTLRELKLSKVgqallQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLE
. ...||.| |.|.|.|| || .|||..    || .. ..|...|    .....|.|.....     . .  | | . .| .|||||||| .  .| |. 
eqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkds.....esgesrevahlnfvkwPdhgvPssaaellqfva

EVHHKQEsimDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL
|| . |.   ||||.||||||||||.||.|.||.....|  .    ..|| .... .| || |.|||. || |.| |. . ...|
evrrlqt...dagPivvhcsaGiGrsGtlitidvvlglierdk...efdvkeivrklreqrqgvvqtkdqyifvykailevlksl
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 247-527 1.6e-66 219.5 In-house 20-277 (515) alignment 
Range on Protein: 247-527
Range on HMM: 20-277/515.0
FWEEFETLQQQEcklLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIiMPEFETkcnnskpKKSYIATQGCLQNTVNDFWRMVF
| |||  |   .   .| .   | . | .|||||||||.| .|| |   . ..| |||.||   .| |..        |.|||.|| .. .|.||||.|.
fseefhdlpgpn...iypqtvaqeeinfkknryknilPydsvrvklevin.dnPhsdyfnasy.ipsfdn.......dkayiasqgPnkasvddfWrlvl

QENSRVIVMTTKEVERGKSKCVKYWPDEYA-LKEYGVMRVRNVKESAAHDYTLRELKLskvgqalLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEE
|||   |.| ||  |  |.|| |||||  .   ..| ..|  |  .|  . . |.|..       |.|.  ||| |.||  |||.||| .   .| .. |
qenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltv.......lkgddsrtvtqfhfteWPdkGvpkhtssllklike

VHHKQESIMdaGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIE
|  ... .    |...|||||.|||| .| ||  .  ...  .   .|| .... .| .|  .|||. || ||| ||. .. 
vkadhgqyt..hpliihcsaGvGrtGvvisidsvvahakttrm...vdvfnfvtnirqkrpylvqtqeqyafiygavledll
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 247-527 4.1e-66 218.0 In-house 21-278 (315) alignment 
Range on Protein: 247-527
Range on HMM: 21-278/315.0
FWEEFETLQQQEcklLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIiMPEFETkcnnskpKKSYIATQGCLQNTVNDFWRMVF
| |||  | . .    | .. .. ..| .|||||||||.|..||.|   | ..| ||||||   .. ...        |.|||.|| |. .|.||||||.
fseefhdlpdPd...iyrqrvaretinfkknryknilPldsarvklevid.dsPdsdyinasy.iksvdd.......dkayiasqgPlkasvddfwrmvl

QENSRVIVMTTKEVERGKSKCVKYWPD-EYALKEYGVMRVRNVKESAAHDYTLRELKLSkvgqallQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEE
||.   ||| ||  |  | || .|||| .  . |.| ..|  .. .|  | . |.| .        .... ||| |..|. |||.||. . . .| .. |
qekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtr.......kseesrtvtqfqftewPdkGvdkqtssllklike

VHHKqeSIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIE
|  .    ..  ...||||||.|||| .| ||  .. |... .   .|| ......|..|  .|||| .| ||| ||. .. 
vkad..ngkkefsllvhcsaGvGrtGvvisidevvaqikrtrs...vdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN14_pd Subfamily PTPN14 247-527 1.9e-65 215.9 In-house 25-297 (300) alignment 
Range on Protein: 247-527
Range on HMM: 25-297/300.0
FWEEFETLQQQECKLLYSrkEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNepVSDYINANIImpefetKCNNSKPKKSYIATQGCLQNTVNDFWRMVF
 . |.| ..... . |.|   .. .||..|||.|..||....|| |     |   ..||||  |      |   .  ..|||..|| |..||.|||.||.
vfteyeripkkredalls..taklpenaeknrfkdvlPyednrvelsptken..stgyinassi......kvsvggkersyivaqgPleltvqdfWqmvW

QENSRVIVMTTKEVERGKSKCVKYWPDE---YALKEYGVMRVRNVKESAAHDYTLRELKLSKVgqallQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFL
... ..||| |.| | || |..||.|..       |.|  .| .   . .. .. . |||  .       . |||||   .  |||||||.|. | |..|
eqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl.....pskeertvwhlqytDWpdhgvPeDvkgflsyL

EEVH---HKQESIM----DAGPVVVHCSAGIGRTGTFIVIDILIDIIREkgvDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIE
|||.   .| .| .       ||.||||||.||||  |. |.||  .     . .||..|.....| ||  .||| |||.|.| .. .|..
eevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatleh...neeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_CG42327_pd Subfamily CG42327 248-450 2.5e-27 90.4 In-house 8-194 (319) alignment 
Range on Protein: 248-450
Range on HMM: 8-194/319.0
WEEFETLQqqecKlLYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDgDPNEPVSDYINANIIMPEFETKCnnskpkkSYIATQGCLQNTVNDFWRMVFQ
 |||. |     . | .| .      |.|.|. |..|. .|||||.   .... . |..|. .    ....       ||||.|  |...  ||||.|..
aeefrdlP....q.liaradevPvtskdksrvinvvPlPetrvvlqr.igdddkdeyldasyvrGyddapn.......syiaaqvsledsssdfwrtvwe

ENSRVIVMTTKEVERGKSKCVKYWPDEYALK---EYGVMRVRNVKESAAHDYTLRELKLSKVgqallQGNTERTVWQYHFrTWPDHGVPSDPGGVLDFLE
 .|||||  |.  | |  .| .|.| . .|.    || ..|   .  . . | .  | | .|     ...  | .  | .  |.. .||...  ..  | 
qqsrvivqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrv.....dkeesrelthywy.kwleaevPaeeaaliamll

EVHHKQ
||.   
evrssl
subfamily_PTPRN_pd Subfamily PTPRN 249-528 4.7e-60 197.8 In-house 33-294 (297) alignment 
Range on Protein: 249-528
Range on HMM: 33-294/297.0
EEFETLQQQECKLlYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDgDPNEPVSDYINANIIMpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMVFQE
.|.|.| . | .   ... .....| .|||.|..||.||.|| |.. . ..  |||||| .|.       ..   . .|||||| | .|| |||.||...
kewealcayeaep.stkevakaeknvkknrskavlpydhsrvklke.easaeksdyinasail.......dhdprapayiatqgplastvadfwqmvweq

NSRVIVMTTKEVERGKSKCVKYWPDEYAlKEYGVMRVRNVKESA-AHDYTLRELKLSKvgqalLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVH
 . |||. |.  | | ..| .||||| . . |..  |. | |   ..|| .| . |       || .  ||| |.|| .||..|||. .  .|.|   | 
GvvvivnltrleeegvkqckrywpdeGs.evyhiyevhlvsehiwcddylvrsfylkn.....lqtsetrtvtqfhflswpeegvPasaksllefrrkvn

HKQESimDAGPVVVHCSAGIGRTGTFIVIDILIDIIrEKGVDcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIET
        . |.|||||.| ||||..|.||.... .  |||  .||.  |.. .| ||.|.|.|..|..|...|| . ...
ksyrG..rscpivvhcsdGaGrtGvyilidlvlnrl.lkGvk.eidiaatlehlrdqrpglvktkdqfefaltavaeevna
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 249-311 1e-07 25.8 In-house 17-75 (244) alignment 
Range on Protein: 249-311
Range on HMM: 17-75/244.0
EEFETLQQQECKLLYSrkEGQRQENKNKNRYKNILPFDHTRVVLHDGDpnEPVSDYINANIIM
|||  | ..  ..| .  .     |  |||| ||||||.|||.|      .  ||||||| | 
eefvglsdhtreflqt..navlsanatknryinilpfdetrvilsssk..kegsdyinanyiq
subfamily_PTPN3_pd Subfamily PTPN3 250-523 4.1e-70 230.9 In-house 20-272 (280) alignment 
Range on Protein: 250-523
Range on HMM: 20-272/280.0
EFETLQQQECKLLYsrKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpnepVsDYINANIIMPEFETKCNnskpKKSYIATQGCLQNTVNDFWRMVFQEN
.||.| ... .|    .. .. || .||||..|||.|.||| |....    . |||||| .  | ....      . |||||| |..|..|||.||....
qfeqlyrkkpglai..saarkpenlsknryrdilpydatrvklkese....t.dyinanyvnmeipstgl....vnryiatqGPlaktatdfWqmvweqk

SRVIVMTTKEVERGKSKCVKYWPDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVgqallQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHK
|..||| |  ||||. || .|||..    ||| ..|.  ||.. . | |||| |..      . . ||.. |  .  |||||||.|.  .|.|.|.|...
sslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdk.....etkeerkilqlqylaWpdhgvPddsadflefvervrkl

QESimDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKgvdCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQ
...  .  |||||||||||||| .|.... . .| ..    .. ... ....| ||. .|||..||.|.  |. 
rsg..keePvvvhCsaGigrtGvlilletalalieaa...epvypldivrtmrdqramlvqtasqykfvCeail
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 259-534 8.3e-60 197.4 In-house 34-292 (297) alignment 
Range on Protein: 259-534
Range on HMM: 34-292/297.0
CKL---LYSRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIImpefetKCNNSkpkkSYIATQGCLQNTVNDFWRMVFQENSRVIVM
| .   ...    ... | .|.|||||||.|  || |.  . ..| |||.||  .      | |.      .|.||   ..||.|||.||..|.  .|||
clpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivn.ddpdsDyvnasfv......kgnkh....rlittqmPmkatvadfWamvldeqvstivm

TTKEVERGKsKCVKYWPDEyALKEYGVMRVRNVKESAAHDYTLRELKLSKVgqallQGNTERTVWQYHFRTWPDHGVPS--DPGGVLDFLEEVHHKQESI
 ... || | || .||.|. . ...| . |     |  . .  |||...|      .  ..| | ||.|  |||. |.   .   .|....||... .. 
lnddnerdk.kcaryWsdk.gvttfGdvsvvllsvsereGfikrelevtkg.....kakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqn

MDAgPVVVHCSAGIGRTGTFIVIDILIDIIREKGvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIE
 .. |..|||.||.|||| .. ||  .  ....    ..|. ......| .|  .|||. ||.|.| ||  .. . . ||.
aeg.PllvhclaGvGrtgvlltidsvvaeakrek...evdifglvkklrqerpylvqtkeqykfvyvavleallsedtriq
subfamily_eak_pd Subfamily eak 261-538 4.5e-25 82.7 In-house 40-317 (332) alignment 
Range on Protein: 261-538
Range on HMM: 40-317/332.0
LLYSRKEGQRQENKNKNrYKNILPFDHTRVVLHDGDPNEpvSDYINANIImpEFetkcnnSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEV
 | | .|..| |. |.|   .|.|.|.  | |     |.    |||| ..  ||      |.  . || |    .. |  ||.||....|  ||.  ..|
rllsisetarleavnrn.vvkivpydrylvrltssqlnr..lGyinasla..ef......sevGrkyiltGiasedkvfafwqmvleqkspaivqlledv

ERGKSKCVKYWPDEY-ALKEYGVMRVRNVKESAAHDYTLRELKLSK------VGQALLQGNTERTVWQYH-----FRTWPDHGVPSDPGGVLDFLEEVHH
| .  |  ||.||.     ..|.. |   .      .  | |.|||      |    . | || |. .|.     ...  . ||.       . |. . .
elkleksdkyfpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsstlk

KQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVDcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQK
|      .   .. .. |  |.|.|.|||.|| .| .|  .    | . |  |.|.|   | .. |. ||| .| .|. . . |... .|
kyihtppsfapiiqsarGsaraGvfvvidllirlidnkkkn.lysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdlkk
0045098 (Phosphotyrosine protein) phosphatases II 264-527 2.4e-80 265.1 In-house 24-273 (278) alignment 
Range on Protein: 264-527
Range on HMM: 24-273/278.0
SRKEGQRQENKNKNRYKNILPFDHTRVVlhdgdpnepvsDYINANIImpefetkcnNSKpKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERG
.  .... .|..|||||.|||.||.||.           |||||. |         ..  .| .|||||.|..||.|||||.......|||| |..||.|
eitpalylgnldknRykdilpydhsrVk...........dYINAsyi.........dgy.pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelg

KSKCVKYWPDeYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALlQGNTERTVWQYHFRTWPDHGVPSDP--GGVLDFLEEVHHKQES---------
. ||..|||.    ..|| ..|....|.  .||||| |..  .     .....|.|...|. .||||||||.|    .|..||.... ..          
rekcaqywpe.ggsltygdftvtllseevlddytlrtllvtnltver.edlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssl

--IMDAGPVVVHCSAGIGRTGTFIVIDILIDIIrekgvDCDIDVPKTIQMVRSQRSG-MVQTEAQYRFIYMAVQHYIE
  . . |||.||||||.|||||......... .     .. .|........|||| | .||.. ||||.|........
llldsggpvlVHCsaGvgRtGtlvaaylmlell.....eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 264-529 1.6e-73 242.2 In-house 19-271 (274) alignment 
Range on Protein: 264-529
Range on HMM: 19-271/274.0
SRKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIImpefetKCnNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERG
...| .   ...|||||.||| ...||.|.  ..... |.||||| |      |   .. .| |.|||| |.|||.|||||..||...||||.||  |. 
dqeeldvfgsqtknryktilPnensrvllesessededssyinanyi......kG.ydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkean

KSKCVKYWPDEYAL---KEYGVMRVRNVKESAAHDYTLRELKLSKVGQallqgntERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESI-MDAGPV
..||..|.||.  .   ..|| . ....|    .||..|.| |... .       ||.|  | .  |||| .| |.  .||...||....|.  . ..||
eqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler.......ersvkhywytdWPdhksPddantlldlvleveesreeenaklapv

VVHCSAGIGRTGTFIVIDILIDIIREkgvDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETL
|||||||||||| || |.| .  .||   .  .|| |..  .| .| |||||. ||..|. |. .| . |
vvhCsaGiGrtGcfiaisiavrqlre...eivvdvlkivcnlrldrGGmvqtseqyelihralclylkrl
0040439 (Phosphotyrosine protein) phosphatases II 265-526 9.3e-82 269.6 In-house 3-246 (249) alignment 
Range on Protein: 265-526
Range on HMM: 3-246/249.0
RKEGQRQENKNKNRYKNILPFDHTRVVLHDgDPNEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGK
.......|||.||||..|||.||.||.|..  |. . ||||||. |        . .. |. .|||||.|..||.|||||.......|||| |..||.|.
ysvallpenkdknrypdilpydhsrvklsi.lpglflsdyinAsyi........dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgr

SKCVKYWPDeYALKEYGVMRVRNVKESAAHDYTLRELKLSKVgqallQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCS
 || .|||.    .||| ..|.....   .|||.|.|.|...     . ...|||.....  |||||||...  .|||.|.|.. .|.. . |||.||||
ekcaqywpl.ggsleygdftvtllsvevkddytvrtleltnl.....ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCs

AGIGRTGTFIVIDILIDIIREKgvdCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI
||.|||||||....... ....   ...|.. .....||||.|.||.. ||||.|.|.....
aGvgRtGtfiaaylmleqleke...lgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 265-522 4.1e-43 142.1 In-house 48-279 (290) alignment 
Range on Protein: 265-522
Range on HMM: 48-279/290.0
RKEGQRQENKNKNRYKNILPFDHTRVVLHDGDPnepvSDYINANIImpefetkcNNSkpKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGK
||  ... . .|||||..   | |||.|.|| .     ||. || .        .    |  .| ||| |..|| |.|||| ||.  .|||  . .| ||
rkifdkntefkknrykdvvcndktrvilkdGyd....Gdyvhanyv........kGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGk

SKCVKYWPDEY-ALKEYGVMRVRNVKESAaHDYTLRELKLSKVGQallQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKqesimdAGPVVVHC
.|| .|.|..      .| . |   .|.  .|  .    ||   .   .   |  .  .. ..|||. |.     .|  |  . .       .|||||||
akceqyypekeGevltfGeitvlcseedd.kdaniikktlsvrdk...dsGkehklkhlkikswpdksvalstlallrtlrilrka......sGpvvvhc

SAGIGRTGTFIVIDILIDIIREkGVdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV
||||||||||. |.. ..|. . |   ..|. .... .|  | . || . ||  .  ..
saGiGrtGtfvaievglqilld.Gk..eldlldlvralrnsrlnsvqvdiqylalveil
subfamily_CG7180_pd Subfamily CG7180 266-526 7.1e-51 167.6 In-house 35-290 (296) alignment 
Range on Protein: 266-526
Range on HMM: 35-290/296.0
KEGQRQENKNKNRYKNILPFDHTRVVLHDGDPNEpVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKs
. | |.||..|||. ...|.|..||||.  | .|  ||||||  .        .    || || |..  ..||..|||.|..|..  .|. ||. .  | 
agglrkenreknrdvkvvPyDynRvvLekldGee.ksdYinavyv........dsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.

KCVKYWPDEYaLKEYGVMRVRNVKESAAHDYTLRELKLSKV----GQALLQG-NTERTVWQYHFRTWPD-HGVPSDPGGVLDFLEEVHHKQESI---MDA
.. .||| .   ..|| . |  |.|    . . |..|| |     ..   |    .|.| ......|.  . ||.   ....... |.  .| .    . 
mypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpee

GPVVVHCSAGIGRTGTFIVIDILIDIIREKGvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI
|||||..| | .|.| .. ||. .. .....    .|| . ....| .| ..|..  .|..||  .....
gPvvvvssdGasRsGvylaidanlelvekee...evdvFeavktlrrsRpqLvenveeYkyiYdvlleav
0049772 (Phosphotyrosine protein) phosphatases II 266-535 4.9e-46 153.2 In-house 39-289 (314) alignment 
Range on Protein: 266-535
Range on HMM: 39-289/314.0
KEGQRQENKNKNRYKNILPFDhTRVVLhDGDPNEPvSDYINANIIMPEfetkcnnskpkKSYIATQGCLQNTVNDF----------WRMVF--QENSRVI
. ..  .|..||||..|||.| .||.| .| |..  ||||||. .              ...||||| |..||.||          ||||.  . |.|.|
lvadlflnrdknryldilpad.nrvil.pglpvsg.sdyinasyvdgf...........lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdi

VM---------------------TTKEVERGkskcvkywpdeyalKEYGVMRVRNVKesaahdytlrE------LKlskvgqallqgntERTVWQYHFRT
||                      ..  ..|               |. .... . |          |      |              ||.. .|.   
vmsrdevladelsrLdaAlgKtpllildgng..............neptaadlellk..........eelydpelf.............erlgikylrip

WPDHGVPsDPGGVLDFLEEVHHKqesiMDAGPVVVHCSAGIGRTGTFIVIDILIDIIrekgvdcDIDVPKTIQMVRSQRS-----GMVQTEAQYRFIYMA
.||...| ..  ...||| ..       . |||.|||.||.||||||.|...|.          .... .....||..|.     |....  || ||..|
vpDgsap.lledfdeflefieea....dkggpvlvHCkaGkgRtgtfvvaaylmkll.......gvsleealedvrlkRpinpnpgfieqleqyefilea

VQHYIETLQRRIEE
...|...|.. .| 
lleylkflkkfyey
0042113 (Phosphotyrosine protein) phosphatases II 267-527 4.4e-80 263.9 In-house 3-244 (245) alignment 
Range on Protein: 267-527
Range on HMM: 3-244/245.0
EGQRQENKNKNRYKNILPFDHTRVVLHdGDPNEPVSDYINANIImpefetKCNNSKPKksYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSK
 ....|||.||||..|||.|||||.|   |.....||||||. .      .. . .||  .||||| |..||.|||||........||| |.|.|.|. |
vallpenkdknrysdilpydhtrvkls.pdggdldsdyinasyv......dgyritpk..fiatqgPlpetvedfwrmlwelgittivmLteeeelgrvk

CVKYWPDeYALKEYGVMRVRNVKESAAHDYTLRELKLSKVgqallQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESiMDAGPVVVHCSAG
| .|||.    ..|| ..|....|    |||.|.|.....     . . .|.|..||.  |||||||...  .|||||.|.. ...  . |||.||||||
caqywpl.gesltygdftvtllseehlddytvrtlevtnl.....gddesrevihyhylpwpdhgvpdllellldflefvrkalae.dsngpvlVHCsaG

IGRTGTFIVIDILIDIIREKgvdCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIE
.|||||||....... ...    ............||||.|.|||. ||||.|.|......
vgRtGtfiaaylmleqleke...lgvsleeavkelrsqRpgavqtpsqyrflyeallellk
0037934 (Phosphotyrosine protein) phosphatases II 268-526 4.2e-78 257.5 In-house 5-242 (243) alignment 
Range on Protein: 268-526
Range on HMM: 5-242/243.0
GQRQENKNKNRYKNILPFDHTRVVLhdgdpnEPvSDYINANIIMPEfetkcNnskpkkSYIATQGCLQNTVND----FWRMVFQENSRVIVMTTKEVERG
....||..||||..|||.||.||.|      |. ||||||| |.       .       .||||| |..||.|    ||||.......|||| |..||.|
allpenlsknrysdilpydhsrvkl......eg.sdyinanliyvt.....p......rliatqgPlpetveddlasfwrmlwelgitvivmltelvElg

KSKCVKYWPDEYalkEYGVMRVRNVKESAAHDYTLRELKLSKVGQALLQgnteRTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQES------IMDAG
. ||..|||.|.   .|| ..|....|.  .|||.|.|.|. ..   |.    |.|..||.  |||||||..|  .||||.||.  .|.      . . |
rekcaqywpgev...tygdftvtllseehlddytvrtlllenldlddlt....rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsgg

PVVVHCSAGIGRTGTFIVIDILIDIIrekgvdcDIDVPKTIQMVRSQRSG-MVQTEAQYRFIYMAVQHYI
||.||||||.|||||.|....... .       ..|. ......|.||.| .|||. ||||.|.|.....
pvlVHCsaGvgRtGtliaaylmllll.......gvdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 268-530 5.9e-73 240.1 In-house 4-246 (250) alignment 
Range on Protein: 268-530
Range on HMM: 4-246/250.0
GQRQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSkC
... .||.|||| .|...|..||||.  .  .  ||||||  .        .  . .|..||||| ||.|..||||||..|.| .||| |. .| .|  .
akkpqnkeknryadiialdssrvvLekek.gdkesdyinasfl........hgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.y

VKYWPDEYAlKEYGVMRVRNVKESAAHDYTLRELKLSKVGQAllqgnTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESiMDAGPVVVHCSAGI
 .||| | | ..|| ..|   ..    ||| |.|||||  .|      ||.| |.|| .||| |||     ||..|..|. .|.   ...||.|.||||.
hqywPveka.ekyGdvtvsllskeefadytkrklklskakka.....derivrqlhfvvWPdkgvPevatavLellkkvqasqqq.agnaPvivqCsaGv

GRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQ
||.|.||.|| ... .... |   .|| | |...| .| ..|....|| |.|...........
grsGafiaidavlerlkkekv...vdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 268-523 8.9e-44 144.5 In-house 28-292 (297) alignment 
Range on Protein: 268-523
Range on HMM: 28-292/297.0
GQRQENKNKNRYKNILPFDHTRVVLHDGDPNepvSDYINANIIMpeFEtkcNNSKpKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKC
 .|.    ||||..|| .| ||| |  . ..   .|||||. ..  |    .. . .  || .|| |..||.|||..|.... ||||| .|  | |..||
akrnsslrknryrdilatddtrvkllrvite...rdyinadyvv..fp...deea.dlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkc

VKYWPDEYALKEYGVMRVRNVKESAAHDYTlrELKLSKVgqALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDF--------------LE-------EV
. |||.    .      | .   | . ..    ..|...   |.  . .| |    | .|||||||||   .  |              |         |
apywpsvvqerlkagdvvveflsstsdefd..rviltel..qliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemftamv

HHKQESIMDAG----PVVVHCSAGIGRTGTFIVIDILIDIIREKGVDcdiDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQ
  . ||.  .     ...||||||.||.|  .  |......| | .    ||   ....|.||. .|||  |. ..| || 
flqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkrip...dvaailsilreqrarlvqtleqfellydavl
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 269-522 6.6e-50 164.6 In-house 29-262 (283) alignment 
Range on Protein: 269-522
Range on HMM: 29-262/283.0
QRQENKNKNRYKNILPFDHTRVVLHDGDPnepvsDYINANIIMPefetkCNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCV
  .|||.|||...|.| |  || |.   .     |||||  |.       .. | .| ||..|. |..|| |||.|||.|.   ||| ||  |  . || 
sadenkrknrnqeivpadqwrvelksesr.....dyinavfipv.....sksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCs

KYWPDEYAlKEYGVMRVRNVKESAAHDYTLRELKLSKVGQAllQGNTErtVWQYHFRTWpdhgVPSDPGGVLDFL---EEVHHKQESiMDAGPVVVHCSA
.||| . . ..|| . |   || . . .. .|| | . . |  . .    .  | .  |    .  ... ... |   . |  .|      ||.|||||.
qyWPkrGs.edyGeftvtlrkettsnsfiikelllrvnssa..kstll..lahyqvidW....leygeqaiinslvkfnkvislqte.skkgPivvhCst

GIGRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV
|||||..|| .   .. .. . |   .||.......| || ..|||  ||.... .|
giGrtavfiaasasvkdaltesv...vdvfavvkimreqrmmavqtldqyklvhelv
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 269-528 4.8e-34 112.6 In-house 29-261 (267) alignment 
Range on Protein: 269-528
Range on HMM: 29-261/267.0
QRQENKNKNRYKNILPFDHTRVVLHDGDPNepvsdYINANIImpefetKCnnSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEverGKSKCV
  ..|...||. . ||.|.|||.| . . .     ||||  .      ..   | |. .|.||. |.||. ||. .. ...  |||. ||    .. .  
iaeknqernrlddnlpyddtrvilrtkeee.....yinasyv......eg..yktknafivtqdplkntitdfltvihdqkvpvivlltkv...ftdnir

KYWPDE-YALKEYGVMRVRNVKESAAHDYTLRELKLSkvgqalLQGNTERTVWQYHFRTWPdhgVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGI
..|| .    |.|  . |    |    || .  |.|       .. .. . |  |... |    . ..    |  |  .  |..      |.||.||.|.
lfwPPkmgqakkyqdltvehslekeendyqiitlelk......fknesahnvtlyyykkwn...intnnkpylkplfgilaknqlengnrPlvvacsdGv

GRTGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIET
||.|||.|||  .. ... ||    |. . .. .|||| |.|.|  .| .|.  . .| | 
GrsGtflvidsqleraktegv...sdifdflrkirsqriglvdtkeryiyihellaeyaeg
subfamily_egg_pd Subfamily egg 269-528 5e-27 89.4 In-house 36-272 (307) alignment 
Range on Protein: 269-528
Range on HMM: 36-272/307.0
QRQENKNKNRYKNILPFDHTRVVLHDgDPNEPVSDYINANIImpefetkcnNSKP-KKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERgkSKC
  ..|..| | | .   | .|| |.       . |.| || .         . ||    .| .|  |.|||.|||||||||. . ||| |  .|    .|
asdnnlekarskrvhckdssrvklel.rrGqylddfihanrv.........kGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erc

VKYWPD---EYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQAllqgNTERTV--WQYHFRTWPDHGVPsdpggvLDFLEEVhhKQEsimdAGPVVVH
  |||    . .    | .|. |.|   . |  .|  ||  ||      . || .  ||. ..   |   |      |  |  .  ..     . ||||.
eyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd....deerflehwqgdvnnssdvysp......lrvlrkl..rnl....skpvvvq

CSAGIGRTGTFIVIDI-LIDIIREkgVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIET
.  |. ...|.. |.| |....|         | ......| .|   |..  .| |.|  |  ..  
dilGvskaatlvaieiallsllrG..pitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrd
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 270-522 3.1e-60 198.3 In-house 5-237 (239) alignment 
Range on Protein: 270-522
Range on HMM: 5-237/239.0
RQENKNKNRYKNILPFDHTRVVLHDgDPNEPVSDYINANIIMpEFetkcnNSKPkKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVK
.. || |||| ||. .||.||||     |.| ||||||. .  ..     .  | |.|||||||.. .  |||||..||   |||| |  .|  | || .
krvnkaknryanivtydhsrvvlek.lsndphsdyinasylr.dy.....dgsp.kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchq

YWPDEYalKEYGVMRVRNVKESAAHDYTLRELKLSKVGQAllqgnTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVhhKQESIMDAGPVVVHCSAGIGR
||||     .|  .||   |     || .| . .|.|||.      || |.||||  |||.|||     || .  ..   ..|.  | | |.|||||.||
ywpdst..skycnlrvtlrktevfadyiirtfvmsqvgqt.....eeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgr

TGTFIVIDILIdiiREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV
||.|.||| ..   |.   .  .|. . .. .| .|  ||||  || ||..||
tgaflvidaml...rqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 270-522 3.2e-60 198.2 In-house 4-236 (239) alignment 
Range on Protein: 270-522
Range on HMM: 4-236/239.0
RQENKNKNRYKNILPFDHTRVVLHDgDPNEPVSDYINANIIMpEFetkcnNSKPkKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVK
.. || |||| ||. .||.||||     |.| ||||||. .  ..     .  | |.|||||||.. .  |||||..||   |||| |  .|  | || .
krvnkaknryanivtydhsrvvlek.lsndphsdyinasylr.dy.....dgsp.kayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchq

YWPDEYalKEYGVMRVRNVKESAAHDYTLRELKLSKVGQAllqgnTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVhhKQESIMDAGPVVVHCSAGIGR
||||     .|  .||   |     || .| . .|.|||.      || |.||||  |||.|||     || .  ..   ..|.  | | |.|||||.||
ywpdst..skycnlrvtlrktevfadyiirtfvmsqvgqt.....eeryvyqyhftvwpdkgvpqyatavlglrrki..tkdslpgarpwvihcsagvgr

TGTFIVIDILIdiiREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV
||.|.||| ..   |.   .  .|. . .. .| .|  ||||  || ||..||
tgaflvidaml...rqakkqktvdifnyvkairedrphmvqtseqyvfihlav
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 270-527 2.6e-36 119.7 In-house 49-291 (310) alignment 
Range on Protein: 270-527
Range on HMM: 49-291/310.0
RQENKNKNRYKNILPFDHTRVVLHDGdpNEPVSDYINANIImpefetKCNNSkpKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVK
 ...  |||| ...  | .|| |.    .    ||| || .      | |    ....| .|| || |. |||||.||| .  |..  | .| |. ||| 
ykkymhknrysdvvcldtsrvklkid..ksryedyihanyv......ktnyl..rstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvg

YWPDEYALKEYGVMRVRNVKESAaHDYTLRELKLSKVGQALLQG----N-TERTVWQYHFRTWPDHGVPSDPGgvldflEEVHHKQESIMDAGPVVVHCS
|||     . ||..|| |. ||. ... . .| .. | . .       |  |  |   ..  ||| ||| .          |  .  . .  ||.|||||
ywpslgvtetygcirvtnlsess.eefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc......htvpqrllaqvrhgpcvvhcs

AGIGRTGTFIVIDILIDIIReKGVDcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIE
||..|... . ... || .. .|    .|. . .  .. .|   .||| || .| .    .  
agkdrlyvvvalklkidkld.rglk..vdaeevktellksraiciqtelqyliidrvriifar
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 270-310 7.3e-07 22.8 In-house 44-83 (440) alignment 
Range on Protein: 270-310
Range on HMM: 44-83/440.0
RQENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANII
  .|| ||||.||| .||.||.|..     | ||||||  |
lpnnkvknryrnilaydhsrvmleevk.gvpdsdyinasyi
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 271-531 4.9e-67 220.8 In-house 18-269 (270) alignment 
Range on Protein: 271-531
Range on HMM: 18-269/270.0
QENKNKNRYKNILPFDHTRVVLHDGDpNEPVSDYINANIIMpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKY
  .|. |||..|||  .|||.|.. . ..... ||||| .          .. ||.|||..| |..|...||||...|... |||||. .|.|..|| .|
argkklnRyadiLPsPatRvrleele.edsataYinAnyvr.......GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPDEYAL---KEYGVMRVRNVKESAAHDYTLRELKLSKvgqallQGNTERTVwQYHFRTWPDHGVPSDPG------GVLDFLEEVHHKQESIMDAGPVVV
|| |       |.| ..|....|. .. | |..|.| .      .|...| |  ... ||||||||....       .|  |..|.. ...  .|.|..|
Wpaepkekvkledgkikvlalseekeegyiltrlrlee......kgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllv

HCSAGIGRTGTFIVIDILIDIIREKGvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQR
|||||.|||||.|..|| . .. |..    .|| . |. .| .|  .||.  ||.|.| ||..|.|....
HcsaGvgRtGtlialDiavrlLeetk...kvdvlaiieelRkdRmalvqhpeqyeflykavveyaerrak
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 271-523 2.4e-66 219.1 In-house 23-252 (284) alignment 
Range on Protein: 271-523
Range on HMM: 23-252/284.0
QENKNKNRYKNILPFDHTRVVLHDGDPNEpVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTkevergKSKCVKY
..||.|||. .||.||...| |.  . .|  ||||||  |        .  . |. |||||| |.||..|||||... |.  ||. |      | || .|
dqnkdknrighilafdknvvklerliGee.fsdyinasfi........tGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqy

WPDEYALKE-YGVMRVRNVKESAAhdYTLRELKLSKVGQAllqgNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGR
|| .   ||  . ..|  |.||.   |..|...||. |.     .  |.. |.||. |||.|||  |  .. ... |.| ..   .  ..|||||||.||
wplkivikeerfkvkvdsveesee..yvvrdielsedgke....kdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgr

TGTFIVIDILIDIIREKgvdCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQ
||..||.|.|.| ..|.     .|| .... .| ||. .||  .|| |||.|. 
tgvyivldvlldrmkee...kqvdvynfvrdlrqqrntlvqdlvqykfiysall
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 271-526 1.3e-39 130.6 In-house 53-289 (305) alignment 
Range on Protein: 271-526
Range on HMM: 53-289/305.0
QENKNKNRYKNILPFDHTRVVLHDgdPNepVSDYINANIImpefetKCNnSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKY
. .. ||||...   |.. | |..  |.   |||| || .       |    |.| .|..|| |..|...|| || |..   |||  | || || || .|
diaitknryqdvpcqdqsavkldk..ps..psdyihanyv......gcp.mipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqy

WPDEYALKE--YGVMRVRNVKESAAHDYTlRELKLSKVgQALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQesiMdagPVVVHCSAGIG
||     |    . . | ||  |   .    |.... . .    |. . .| . ..  ||| |||      |..|  .   .   .   |.|||||||||
wpaaqgeklelksgivvenvsgskpmerd.aeiqitll.nltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk...v...pivvhcsagig

RTGTFIVIDILIDIIREKGvDCDiDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI
|||| . |. ... | |.  .|   .|. .. .| ||.  .|.. || ||.  .  |.
rtgtivaieyilekiaenk.pcp.pmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 271-525 4.4e-34 112.4 In-house 35-268 (281) alignment 
Range on Protein: 271-525
Range on HMM: 35-268/281.0
QENKNKNRYKNILPFDHTRVVLHDGDPNEPVSDYINANIIMPEFEtkcnnskpKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKY
  |..|||| ||  .| .|| |.   ||.  .||| || |   |         |. || |||  ..|  |||||..|||.  |||  . .|  . || .|
pvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspfl........krgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaey

WPDE-YALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQAllqgnteRTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKqesimdAGPVVVHCSAGIGR
.| . ..  ..  . |     .  .      |.||  |..       | . .. .. |||  ||     .|  | ... .      . | |.|||||.||
fprnahcclqfdklsvsyedstvnkslvttrlnlsyeget.......rlithwlwkewpdwqvpessevmlkilrkirar......stppvihcsagvgr

TGTFIVIDILIDIIREKGVDCDIDvpKTIQMVR-SQRSGMVQTEAQYRFIYMAVQHY
.||.. ..| .. |. .    ||   . .  .| . |.  |||  || .|.  .  .
sgtlmaveialqsihshftlpdik..qivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 271-538 5.9e-22 72.4 In-house 49-297 (302) alignment 
Range on Protein: 271-538
Range on HMM: 49-297/302.0
QENKNKNRYKNILPFDHTRVVLHdgdpNEPvSDYIN-ANIIMPEFetkcnnskpKKSYIATQGCLQN---TVNDFWRMVFQENSRVIVMTTKEVERGKsK
..| .||. ...   |...| |.    .||  .|.| ... .||.         ..| | .|   ..    |..||||||||.   .|.  .| |  |  
kknlkknqsedvpildsnlvkle....aep.dsyvnaskvevPel.........trsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.t

CVKYWP-DEYALKEYGVMRVRNVKESAAHDYTlRELKLSKVGqallQGNTERTVW-QYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDagPVVVHCS
  ...|    . |||| |.| | | . |.. .  .. .  .     .| ..  .   |..  |... ||   . .    ..|..|...  .  ..|.   
lselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlP....egcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikade..ntvivSk

AGIGRTGTFIVIDILIDIIREKgvdCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQK
 |.|| |.|..  . .. . ..    .  .  ... .||||. .|..  || ..|.|.  || .  .. ||..|
nGaGRagafltlavaveklqkg...kepnikeivksiRsqRpravdslkQyvslyialllyikkkvtkpeekkk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 271-526 4.9e-18 59.8 In-house 45-279 (303) alignment 
Range on Protein: 271-526
Range on HMM: 45-279/303.0
QENKNKNRYKNILPFDHTRVVLHDgdpnepvSDYINANIImpEFETKcnnskpkKSYIATQGCLQNTVNDFWRMVFQENSRV--IVMTTKEVERGKSKCV
 .| .|||. ... .||..| | |       | || |. .  |....       |  | ||  |. |  |||.|. ... ..  ...|  | ..   . |
vknmdknrfvdvicldhskvklsd.......ssyihasyl..eldss.......kkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsv

KYWPDEYALKEYGVMRVRNVKESAAHDYtlRELKLSKVGqallQGNTERTVWQYHFRTWPDHGVPSD-PGGVLDFLEEVHHKQESIMDAGPVVVHCSAGI
    ...   |  ..|| . |.    |     ||.  |     .|.    .  .|...||   .|||    ..  . ..        |. | |    .| 
fprnqdflkfeersirvgefkrvelgdg..wvlkvlsvs....ngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgc

GRTGTFIVIDILIDIIreKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI
||.||| ...     .  .  .  .|. | ...||  |   ||  .|. ..|  .  ..
gragtfalfetahlsl..hseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 272-522 1.8e-60 199.1 In-house 2-235 (237) alignment 
Range on Protein: 272-522
Range on HMM: 2-235/237.0
ENKNKNRYKNILPFDHTRVVLHDGDPNepvSDYINANIIMpEFEtkcnnSKPkKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYW
||| |||| ||  .||.||||.    .   ||||||. .  .|.       | |.|||.|| |... .|||.||.||.  |||| |  .|. . || |||
enkiknrygnivaydhsrvvlkgagsg...sdyinatylk.gfd.....gtp.kkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkyw

PDEYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQALlqgnTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTG
|.    . |||. |   |. .  |||.| | ||| ..        | ..||.| .|||.|||     .| |  .. .. . . ..|| ..|||||.||||
pstdqpaaygvltvslkkkeefsdytvrslllskrltlk....evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtg

TFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV
 |.||| ..   .|| |   .|. . .. .  .|  ..||. || ||. ..
iflvidamlrqakekkv...vdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 272-526 1.5e-27 91.3 In-house 34-270 (285) alignment 
Range on Protein: 272-526
Range on HMM: 34-270/285.0
ENKNKNRYKNILPFDHTRVVLHDGDpnepvSDYINANII-MPefetkcnnSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKY
 | . ||| ..   . |||||.. |      ||| |. . ||         | . .||.||| | .|..|||.|..||.   ..|    .| |  ||  |
anpdlnryadvrcieetrvvlknhd.....rdyihaswmrmp........gkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WPDEYA-LKEYGVM--RVRNVKESAAHDYTLRELKLSKVGQALLQGNTertVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQesiMDAGPVVVHCSAGI
.|..   . ..|     . ..|| |     |  | . .  .|  .      . . .   |||.  | |   .... . |.. .       |..||||||.
ypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseply...mnhvqvpwwpdqlapedarpmielykwvkkvn...pkekpicvhcsagv

GRTGTFIVIDILIDIIREkgvDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYI
||| ||. ||     | |   . .|..   .. .|. |   ||.  |. |.|. .  |.
grtatfvgidyatirime...npniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 272-353 1e-09 32.4 In-house 36-113 (347) alignment 
Range on Protein: 272-353
Range on HMM: 36-113/347.0
ENKNKNRYKNILPFDHTRVVLHDGD----PNEPVSDYINANIImpefetKCNNSkpKKSYIATQGCLQNTVNDFWRMVFQENSRVI
 . .||| |.    | |||||   .    . ..|  ||||  |      | .|.  .| || ||  | .|| |||.||.  .   .
kslsknrskdvklidatrvvlspeksknsraddvetyinashi......kfdna..skeyiltqyplpdtvrdfwkmvsvtkvtqv
Y_phosphatase Protein-tyrosine phosphatase 273-523 2e-83 274.8 Pfam-A 1-234 (235) alignment 
Range on Protein: 273-523
Range on HMM: 1-234/235.0
NKNKNRYKNILPFDHTRVVLhdgDPNEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWP
||.|||||.|||.|.||| |   . .|  |||||||..        .. | ||..|||||.|..|..||||||.||...|||| |...|.|. || .|||
nkkknRykdilpydktrvkl...kgsegpsdYInAnyv........kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp

-DEYALKEYGVMRVRNV-KES-AAHDYTLRELKLSKVGQALlqgnTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQesIMDAGPVVVHCSAGIGR
 .|   ..|| ..|... ||. . ..||||.|.|.| ..       .|.|.|.|. .|||||||..| ..||....|....    . ||||||||||.||
eeeeesltygdikvelkekekedekeytlrklelkkkkees....ekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgR

TGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQ
||||...|||.. .....    .|| ......|.|| ||||...|| |.|.|..
tgtfvaldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 273-523 2e-83 274.8 In-house 1-234 (235) alignment 
Range on Protein: 273-523
Range on HMM: 1-234/235.0
NKNKNRYKNILPFDHTRVVLhdgDPNEPVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWP
||.|||||.|||.|.||| |   . .|  |||||||..        .. | ||..|||||.|..|..||||||.||...|||| |...|.|. || .|||
nkkknRykdilpydktrvkl...kgsegpsdYInAnyv........kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwp

-DEYALKEYGVMRVRNV-KES-AAHDYTLRELKLSKVGQALlqgnTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQesIMDAGPVVVHCSAGIGR
 .|   ..|| ..|... ||. . ..||||.|.|.| ..       .|.|.|.|. .|||||||..| ..||....|....    . ||||||||||.||
eeeeesltygdikvelkekekedekeytlrklelkkkkees....ekrevkqlhytnWpdhgvpespkslldlirkveksk..eaksgpvvVhCsaGvgR

TGTFIVIDILIDIIREKGVdcdIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQ
||||...|||.. .....    .|| ......|.|| ||||...|| |.|.|..
tgtfvaldilleqleaeee...vdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 273-527 1.4e-54 179.7 In-house 1-172 (182) alignment 
Range on Protein: 273-527
Range on HMM: 1-172/182.0
NKNKNRYKNILPFDHTRvvlhdgdpnepVSDYINANIIMpefetkcnNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTkevergkskCVKYWP
|..||||..|||.||.|           ..||||||...         | | . .||||| |..||.||.||. ... ..||. |         .. |||
nldknrysdilpydhsr...........dldyInanlyl........gslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp

DEYalkeygvmrvrnvkesaahdytlrelklskvgqallqgntERTVWQYHFRTWPDHGVPSdPGGVLDFLEEVHHkqesimDAGPVVVHCSAGIGRTGT
...                                        ||...||..  |||||||. .  .|||.|||..      . |||.||||||.|||||
ell........................................erlgiqylylpwpDhgvpd.ldelldfieevle......eggpvlVHCsaGvgRtgt

FIVIDILIDIirekgvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIE
........          ..........|||.|.|||.|. ||.|...|. ....
lvaaylmkkl........gvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 273-527 1.7e-36 120.8 In-house 43-272 (288) alignment 
Range on Protein: 273-527
Range on HMM: 43-272/288.0
NKNKNRYKNILPFDHTRVVLHDgDPNepvsDYINANIIMpefetkcnNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWP
|  ..||.|.   | ||| |.| ||.     ||.||..          .| |.  | .|  |. |.. .|.|..... . ||| .. .|.|| |  .|.|
nptrdryenlprcditrvklsd.dpd....fyiaanvvs........sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfP

DEYALKEYGVMRVRNVKESAahDYTLRELKLSKVGQAlLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVhhkqESIMDagPVVVHCSAGIGRTGT
 .   |         ||..   .   . .|.| .     .|...  | . |.. |.|.||| .    | .|| .    .|.    |.|||.|||.|||||
sklGekarigrlctvvkkkr..adidklvkvsllris.kegeekvivkilhlleWdddgvPenylsplrllevl....kslqk..PivvhssaGvGrtgt

FIVIDILIDIIRekgVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIE
.|.| | .. .|   .| .. ... ..  | .|   .||| || ...  | ... 
lililialeslr...lddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 273-391 3.9e-25 83.3 In-house 47-168 (350) alignment 
Range on Protein: 273-391
Range on HMM: 47-168/350.0
NKNKNRYKNILPFDHTRVVLHDGD-------PNEPVSDYINANIIM-PEFETKCNNSKpkkSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGK
   |||||||||..|.|| |. .             .|||||| .  . |  . | .     |||||. |..||.||...... . .||.. |..|| . 
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdf...kYiatqaPlpstvddfykvillnkvkvilsltsdvelnl

SKCVKYWPDEyALKEYGVmRVRNVKES
 || .||..  . ... | .. . .|.
ekcyrYWqeg.sydditv.klaskwen
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 273-545 3.4e-22 73.9 In-house 19-279 (290) alignment 
Range on Protein: 273-545
Range on HMM: 19-279/290.0
NKNKNRYKNILpFDHTRVVLHDGDpNEPVSDYINANIIM-PEFETKCNNSKPKKSYIATQgclQNTVNDFWRMVFQENSRVIVMTTKEVERGKS----KC
.. ..|... | . .|||||..   .  ..||| || .  |.       . |..  . ..   . |...|| |. ||... .||. .  |. .      |
hemdqRlevpL.veatrvvLkgyg.krfnddyiHAnrvtcpnglrliltqsPqekitekr...nStiekfwwmakqEkvkqvVmlcefeeksantslfaC

VKYWPDEYA--LKeYGVMRVRNVKESAAHDYTLRELKLSkvgqalLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQesimdaGPVVVHCSA
 || |..    || .. . |.  .  .  |   ||| .        ... | ||  . .. | .  |. |.  .|. .. |. ..       ||.|||  
akYvpesvgeelk.fkgltvkCkskekeddvetRelvvk......fddeeeftvtHsllkgWnklnvqedtktllsliqkvkask......tpvivHcvd

GIGRTGTFIVIDILIDIIREKGVdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKS-KRKGHE
|| |  ..  |..    | |.    .. . . ....|.||  ..... .. |.  ..  ..   .....||..  | | .|
GiSrsAalaaiilgyQkiaetsg..svkledvlkalrkqralaitsalelafvdagivllaievldqfaeeetekkakaee
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 273-373 5.7e-15 49.5 In-house 48-155 (349) alignment 
Range on Protein: 273-373
Range on HMM: 48-155/349.0
NKNKNRYKNILPFDHTRVVLHDGDPNEPV-------------SDYINANII-MPEFETKCnnskpkkSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTK
   |||||.|||..|.||.|. .  .  |              |||||| . .......         |||||  |  ||.||....  .. ....  ..
lfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvek.......kyiatqaPlPstvddfykvillngvklvlsLnd

EVERGKSKCVKYWPD
. | .  || .|| .
dkelslekcdiywqe
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 274-520 1.4e-29 97.8 In-house 51-275 (301) alignment 
Range on Protein: 274-520
Range on HMM: 51-275/301.0
KNKNRYKNILPFDHTRV-VLHDGDPNePvsdyINANIIMPEfetkcnnSKPKKsYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWP
|.|.||...    .| | |. ||    |    | || |  .        .|.. .||||| |.|| .||| |. | .   ||| ...||. ..|| .| |
kdkhryptvPckPstavevivdGkrv.P....ihanwipts.......Ghphr.fiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylp

DEYAlKEYGVM----RVRNVKESAAHDYTLRELKLSKVGQALlqgnTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQEsimdagPVVVHCSAGIG
 . . ..  .     ...| .    .. . |.|..    . .    . |||  | . .|.|.|||     . |..| | . ..      |.|||||||||
vkis.ekldigrfkikiknkelilnkkiskrtlevedstgkf....atrtvthyqysewtdrgvPkshaelfdlmelvkksek......PivvhcsaGiG

RTGTFIVIDILIdiiREKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYM
|. .||  ..|    ||   |  |.. .... .| .|   |||. |  .. .
rsvafigteyla...reveadptieltealkhlrehrwngvqtnsqlywmtl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 274-550 5.5e-28 92.6 In-house 44-300 (312) alignment 
Range on Protein: 274-550
Range on HMM: 44-300/312.0
KNKNRYKNILPFDHTRVVLHdGDPNEpvsdYINANIImpefeTKCnnSKPKKsYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPD
|. ||| ||  .|  |  |  || |     || ||..       |  .||.. ...||| |.||.  ||....   |  |.. .  || |  ||.||  |
kdlnrypniqcwdrgrftla.gdenf....yihanfv.....kic..tkper.fvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisd

EYALKEYGVMRVRNVK-------ESAAHDYTLRELKLskVGQAllqGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHkqesimDAGPVVVHCSAG
  .. .    ||             .    | | ||.  | .|      |  . .| . .|||||.|      | .|  |..      |  ||. |||||
ivgfvdledhrvyteycteieiggkskdkithrvlkv..vvka...tgqesklnhyqwaswpdhgmpdscdtalrllsavkk......dkkpviahcsag

IGRTGTFIVIDILIDIIREKGvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKSKRKGHEYTNIK
.|||||...|. .|  .|        .| ..  ..| .|.  |.. .|| .   .| ... .      .||.  .  . |..||
vgrtgtlaliesmiaalrhpr...kqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskglykrneqewtkfketyakik
0044763 (Phosphotyrosine protein) phosphatases II 284-525 1.9e-36 120.7 In-house 1-170 (178) alignment 
Range on Protein: 284-525
Range on HMM: 1-170/178.0
PFDHTRVVLHDGdPNEPVSDYINANIIMPEfetkcnnskpkkSYIATQGClqntvNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYAlkeygvm
|.|.|||.|.   .... ||||||. |.|              |......      |..... ... ..||. |.|.|.|. || .|||.|.        
pldrtrvllsnl.eglersdyinaseilpg............lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.......

rvrnvkesaahdytlrelklskvgqallqgntertvWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQEsiMDAGPVVVHCSAGIGRTGTFIVIDILIDIi
                                    .||..  .||||||. .  .|.|.| ... ..   . |||.||||||.||.||........   
....................................iqylhipipDhgvpdllehflefvefieeald..ekggpvlVHCsaGvgRsgtlvaaylmkkl.

rekgvdcDIDVPKTIQMVRSQRSgMVQTEAQYRFIYMAVQHY
       ...... |..||..|. .|... |.|..|.  ...
.......glsleeaielvrerRp.ivpnpgqlrqLyefelrl
0046846 (Phosphotyrosine protein) phosphatases II 299-526 2.9e-45 149.5 In-house 9-173 (176) alignment 
Range on Protein: 299-526
Range on HMM: 9-173/176.0
EPVSDYINANIIMPEFetkcnnskpkksYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDeyaLKEYGVmrvrnvkesaahdytl
.. .||||||.|.  .            .||||| | .|. ||..|..... ...|. |.||| |. ||  |||.   |...|.                
dldldyinanlilgsr............piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe...leklgi................

relklskvgqallqgntertvwQYHFRTWPDHGVPSDpGGVLDFLEEVHHKQESimdAGPVVVHCSAGIGRTGTFIVIDILIDiirekgvDCDIDVPKTI
                      ||..  |||||||..   .|..||...  ...    |||.||||||||||||......|.        .....| ...
......................qylhlpwpDhgvpdl.elllellefirealke...ggpvlVHCsaGigRtgtlvaayllel.......ekglsveeal

QMVRSQRS-GMVQTEAQYRFIYMAVQHYI
..||.||. |.|||..||||.|.......
alvreqRplgavqtpeQyrflyefellll
0051429 (Phosphotyrosine protein) phosphatases II 300-530 1.3e-53 177.7 In-house 2-229 (272) alignment 
Range on Protein: 300-530
Range on HMM: 2-229/272.0
PVSDYINANIIMPEfetkcNNSKPKKSYIATQGCLQNTVNDFWRMvFQENSRVIVMTTKEVERGKSKCVKYWP-----------DEYALKEYGVMRVRNV
|.|.||||. .        ..   .. .....|.|..|..||||.  ... ..||. ..|.|||. || .|||           |..   .|| .||...
plsgyiNardvggy.....grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtll

KESAAHDYTLRELKLSKVGQALLQgnteRTVWQYHFRTWPDHGVPSDPggVLDFLEEVHHkqesimdAGPVVVHCSAGIGRTGTFIVIDILIdiiREKGV
.|.  .||.|||| |... .|       |.|...|.. |||||||...  .|..||....        |||.||||||..||||......|.   .  . 
seellldyilrellltlllsagea....revmhlhytdwpdhgvpqea..llellellld.......ggpvlvHCsaGkdRTGtvvalllll...lgvsl

DCDID--------VPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQ
.. .|        . ......|.|| |.||||.||.|.|.|.......|.
etivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsll
0043147 (Phosphotyrosine protein) phosphatases II 300-522 1.7e-45 150.2 In-house 3-157 (172) alignment 
Range on Protein: 300-522
Range on HMM: 3-157/172.0
PVSDYINANIImpefetkcNNSKPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEvergkskcvkywpdeyalkeygvmrvrnvkesaahdytlr
. ||||||. .        . .   ...|||||.|.||..|||||. ... ..||. |..                                        
egsdyinasyl........dlyyipdrfiatqgplrntladfwrmlkelgithivnltel........................................

elklskvgqALLQGNTERTVWQYHFRTWPDHGVPsDPGGVLDFLEEVHHKQeSIMDAGPVVVHCSAGIGRTGTFIVIDILIdiirekgvdCDIDVPKTIQ
          ..  . ||...||..  ||||||| ..  .|.||| .....  . . |||.||||||.|||||........         ..... ....
.........lydpellerlgiqylylpwpDhgvp.llellleflefidell.alspggpvlVHCsaGvgRtgtlvaaylml.........lglsleeava

MVRSQRSGMVQTEAQYRFIYMAV
.||..|.|.||.. ||||.|.  
lvrekRpgavqnpsqyrflyyfe
0051082 (Phosphotyrosine protein) phosphatases II 300-521 2.6e-34 113.4 In-house 1-148 (151) alignment 
Range on Protein: 300-521
Range on HMM: 1-148/151.0
PVSDYINANIIMPEfetkcnnskpkksYIATQGCLQntvnDFWRMVFQENSRVIVMTTKEVERGksKCVKYWPDEYalkeygvmrvrnvkesaahdytlr
|.|||||.. . .              .....| |.    ||.... ... ..||. ..|.|||  .| .|.|..                         
plsdyinfsyvtgg.............lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg........................

elklskvgqallqgnteRTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHkqesiMDAGPVVVHCSAGIGRTGTFIVIDILIdiIRekgvdcdIDVPKTIQ
                 ..|.....  |||.|.|  .  ||.|||.. .     .. |||.||||||.|||||........   .       ... ....
.................ievlhipildwpdpglplsfdavleflellld.....kkngpvlvHCsaGkgRTGtlvalylml..lg.......vsleeale

MVRSQRSGMVQTEAQYRFIYMA
..|..| |.||.. |..|...|
eyrlkrpgvvqpnqqflfqlfa
0036282 (Phosphotyrosine protein) phosphatases II 302-519 5.4e-44 145.3 In-house 2-163 (174) alignment 
Range on Protein: 302-519
Range on HMM: 2-163/174.0
SDYINANIIMPEFETKcnnskpkkSYIATQGCLQntvndFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDeyalkeygvmrvrnvkesaahdytlrel
||||||. .     |.         .||.||.|.     ||.|.........|| ..|.|.|. ||  |||.                            
sdyinaspldlsyitp........rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe............................

klskvgqalLQGNTERTVWQYHFRTWPDHGVPSDPGgVLDFLEEVHHKQESiMDAGPVVVHCSAGIGRTGTFIVIDILIDIIRekgvDCDIDVPKTIQMV
         |.   ||...||..  |||||||...  .|.|...|.. ...  . |||.||||||.|||||........  ..       .|. ......
.........lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealse.dpggpvlVHCsaGvgRtGtlvaaylmlrgll....eslvdaldlvrel

RSQRSGMVQTEAQYRFIY
|.||.|||||. ||||.|
RlqrpgmvqtpsQyrfly
subfamily_hpo-7_pd Subfamily hpo-7 321-529 6.4e-20 66.1 In-house 34-230 (263) alignment 
Range on Protein: 321-529
Range on HMM: 34-230/263.0
SKPKKSYIAtqgcLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEYgVMRVRNVKESAAHDYTLRELKLSKVgqaLLQGNTERTVW
 | |..|.     | .|.. |.... | .. |.|| .   | |. || .|.| |   |   .  |  .   . .|  |. |.| ..   | .  . .|| 
kkrknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqk.lanvnvcttkvqsdvllktlellst...lgeKkkthtvk

QYHFRTWPDHGVPSDPGGVLDFLEEVHHKQesimdagPVVVHCSAGIGRTGTFIVIDILID-IIR--EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRF
.| .. |...  | ..  .|  |. . . .       ..|||||.||||.  | |....   .||  ..    ..|  . .. .||.|.. ..|  |  |
hysykgWiekndpelareilnilkvarnsk.......slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLaf

IYMAVQHYIETL
  . |  ..   
silmvLdfvlnn
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 322-520 2.2e-24 80.7 In-house 2-198 (199) alignment 
Range on Protein: 322-520
Range on HMM: 2-198/199.0
KPKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPD-EYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQAllqGNTERTVW
| .. |||||  |..|. |||.||..  |  |||   .    ..    |||  | .  .|| . |     ..  |||.  | |..   |     . | . 
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntta...ppstreis

QYHFRTWPDHGVPSDP--GGVLDFLEEVHHKQESIMDAgPVVVHCSAGIGRTGTFIVIDILIDIIrEKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFI
.| | .| ..  |      | .    || .| |   || ||.|||| | | || |. .|| .    |.     .|. .  . .|  | |.. .  .| ||
hyqftswkekttpnvalfvgfvvasrevskkyeqekda.pvivhcsdgqgftgvfvaldigvrsh.eesktsvvdlfevakrlrqarcgiisslqhynfi

YM
| 
yq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 322-542 3.6e-23 77.0 In-house 32-236 (255) alignment 
Range on Protein: 322-542
Range on HMM: 32-236/255.0
KPKKSYIAtqgclqnTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYALKEY-GVMRVRNVKesAAHDYTLRELKLSkvgQALLQGNTERTVW
| |..|.        ||. |.... | .. |.|| .   | |. || .|.| |   |     . |   |  .. |  || |..      | .    .|| 
krknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleit...stlgekkkthtvk

QYHFRTWPDHGVPSDPGGVLDFLEEVHhkqesimDAGPVVVHCSAGIGRTGTFIVIDILID-IIR--EKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRF
 |... |...  | ..  .|  |  |.       |. .||||||.||||. .|......   .||  ..    ..|  . .. .||.|.. ..|  |  |
hysykGWieknaPelareilnilkvvr.......dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlaf

IYMAVQHYIeTLQRRIEEEQKSKRK
  . |  ..   .  .|.. .  ||
silmvldlv.fpkgeleakyqeirk
0049260 (Phosphotyrosine protein) phosphatases II 323-519 1.3e-42 140.4 In-house 7-143 (152) alignment 
Range on Protein: 323-519
Range on HMM: 7-143/152.0
PKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWpdeyalkeygvmrvrnvkesaahdytlrelklskvgqallqgntertvwQY
... .|||||.. ||..|||||. . . ..||| |...|.|| || .|.                                                 ||
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.................................................qy

HFRTWPDHGVPSDPGGVLDFLEEVHHKqeSIMDAGPVVVHCSAGIGRTGTFIVIDILIdiirekgvdCDIDVPKTIQMVRSQRSGMVQTEAQYRFIY
..  |||||||...  .|..|. ...    . . |||.||||||.|||||........         ..... .....||..|.|.|... |.||.|
lhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml.........lgvsleeavalvrekRpgavpnpgqlrfly
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 323-381 1.3e-06 22.0 In-house 234-289 (440) alignment 
Range on Protein: 323-381
Range on HMM: 234-289/440.0
PKKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERgksKCVKYWPDEYALKEYG
 |...||||  |. || ||||.| . .   |.|  .  ..    |  ||| .     .|
kknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfg
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 324-520 2.7e-24 80.4 In-house 3-197 (198) alignment 
Range on Protein: 324-520
Range on HMM: 3-197/198.0
KKSYIATQGCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPD-EYALKEYGVMRVRNVKESAAHDYTLRELKLSKVGQAllqGNTERTVWQY
.. |||||  |..|. |||.||..  |  |||   .    ..    |||  | .  .|| . |     ..  |||.  | |..   |     . | . .|
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntta...ppstreishy

HFRTWPDHGVPSDP--GGVLDFLEEVHHKQESIMDAgPVVVHCSAGIGRTGTFIVIDILIDIIrEKGVDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYM
 | .| ..  |      | .    || .| |   || ||.|||| | | || |. .|| .    |.     .|. .  . .|  | |.. .  .| ||| 
qftswkekttpnvalfvgfvvasrevskkyeqekda.pvivhcsdgqgftgvfvaldigvrsh.eesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 332-522 1.8e-22 74.2 In-house 98-284 (302) alignment 
Range on Protein: 332-522
Range on HMM: 98-284/302.0
GCLQNTVNDFWRMVFQENSRVIVMTTKEVERGKSKCVKYWPDEYA----LKEYGVMrVRNVKESAAHDYTLRELKLSKVGQ--ALLQGNTERTVWQYHFR
   ..|.. .| .. | |  ..|  .. || .. || .|. |.      ...| |    .||.  ..    ...|| .|       . ....||   .| 
vpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvk.tvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

TWPDHGVPSDPGGVLDFLEEVhhkqESIMDAgpVVVHCSAGIGRTGTFIVIDILIDIIREKGVDcdiDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV
.||||| | ..   || |       ||   .  |.||||||.|||||.. |   |..  .| |    |. . .. ||. | | ||.| |  .. . |
awpdhGapkeaytaldilkfc....esykkn..vlvhcsaGvGrtGtlvaikyGiqlcskkkvt...dllsivlpvrqcryGavqdeqqliylllcv
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 336-527 1.3e-10 34.5 In-house 129-310 (346) alignment 
Range on Protein: 336-527
Range on HMM: 129-310/346.0
NTVNDFWRMVFQENSRVIVMTTKEvERGKSKCVKYWPDEYALKEY-GVMRVRNVKESAAHDYtlRELKLskvgQALLQGNTERTVWQYHFRT-WPDHGVP
  |.||| |..||. ... .   . .. |      . ||    .| | | . | .   . |   .|  .    . | .||..  . | |  . |     |
sfvedfwymiyqeqihlvylmvpd.dklkntttslfndenggyqytgkmfinnrradvsgdp..keyti....evlpegnsdsvicqvhhhapwkhlqqp

SDPGGVLDFLEEVHhKQESIMDAGPVVVhCSAGIGRTGTFIVIDILIDIIrEKGVDCDIdvPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIE
     .. .. . .  .. . .||  ||    | ||. .||     |. . . |.. .|   . .. .. || | |.. |||  ||  |  || 
pktlpiikmihqfl.sekqvqnagvcvv.slfgcgracsfigalyainql.nngiepni..ceimknikqqrpggvesfaqyasiyaivfdyia
0048076 (Phosphotyrosine protein) phosphatases II 373-525 3.1e-31 103.4 In-house 21-142 (145) alignment 
Range on Protein: 373-525
Range on HMM: 21-142/145.0
DEYALKEYGVMRVRNVkesaahdytlrelklskvgqALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESimdAGPVVVHCSAGIGRTGT
|   ||..|. .| |.                    .  . . ||...||..  |||||||...  .|.||| ... ...    |||.||||||.|||||
dlellkdlgittvlnl....................tselellerlgiqylylpwpDhgvpdllellleflefieealke...ggpvlVHCsaGvgRtgt

FIVIDILIDiirekgvdCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHY
........         ...........|||||.|.|... |.||.|......
lvaaylmll........lgvsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 373-520 3.1e-29 96.9 In-house 21-139 (144) alignment 
Range on Protein: 373-520
Range on HMM: 21-139/144.0
DEYALKEYGVMRVRNVKESAAHDYTLRElklskvgqallqgntertVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQEsimDAGPVVVHCSAGIGRTGT
|   ||..|.  | |. |.  ...  ||                  ..||..  |||||||...  .|.||| ... .|   . |||.||||||.|||||
dlellkklgittvinlteeyepeflere..................giqylhlpwpDhgvpdllellleflefieeale...eggpvlVHCsaGvgRtgt

FIVIDILIdiirekgvDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYM
........         ..... .....|||.|.|.|... |.||...
lvaaylmk........klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_PTPDC1_pd Subfamily PTPDC1 377-522 9e-11 36.5 In-house 42-172 (182) alignment 
Range on Protein: 377-522
Range on HMM: 42-172/182.0
LKEYGVMRVRNVKESAAHDYTLRELKlsKVGQALLQGNTERTVWQYHFRTWPDHGVPSdPGGVLDFLEEVhhkqESIMDAGPVVVHCSAGIGRTGTFIVI
.|| |.  | |..|.  |      |.  . | .  . .  ..   ..  .|.|.||.|    .||    |    .. .. | | ||| || ||||  |  
fkesgikavinLqekgehasCGagle..esGfsYdlealmeqgiyvynfgwkDygvas.leriLdivkvv....afalqegkvavhChaGlGrtGvliac

dILIdiiREKgvdcDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV
 .|.     |    ...  |.|..|||.|.  .||  | ...    
.ylv...yak....rltaekaiklvrskrpksiqtreqvelvkefa
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 409-538 2.6e-23 77.1 In-house 81-206 (440) alignment 
Range on Protein: 409-538
Range on HMM: 81-206/440.0
ALLQGNTERTVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESImDAGPVVVHCSAGIGRTGTFIVIDiliDIIREKGVDCDIDVPKTIQMVRSQRSGM
. ..|   ||. |||.. |||.|||   | || ....| . ||     ||..|||||| ||||  |..|    |.||     .||.   |. .|..|  |
syingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqeka.gngpllvhcsagagrtgviiavd...silreakrsdqidifsfinsmrnnrpqm

VQTEAQYRFIYMAVQHYIETLQRRIEEEQK
|||  || |.. || . . . .  | |.. 
vqtpeqyafvheavlegllcgdtlileddi
subfamily_CDKN3_pd Subfamily CDKN3 409-519 8e-06 19.6 In-house 90-189 (202) alignment 
Range on Protein: 409-519
Range on HMM: 90-189/202.0
ALLQGNTERTVWQYHFrTWPDHGVPsDPGGVLDFLEEVHHKQESimdAGPVVVHCSAGIGRTGtfIVIDILIDIirekgVDCDIDVPKTIQMVRSQR-SG
 ||.  ..  .  .|.   .| .|| |.   |..|||..   ..       .|||  |.||.   .||  |. .     .|  |.  ..|. .|  . |.
rlldlyqqaglivhhy.piadglvp.diasclkileelrinlka...yrktlvhcygglgrss..lviacllly.....lddtiepkdaidklrdlkgsr

MVQTEAQYRFIY
 .||  || .. 
aiqtvkqynyls
PTPc_DSPc_SM00012 418-523 7.8e-37 121.1 In-house 1-104 (105) alignment 
Range on Protein: 418-523
Range on HMM: 1-104/105.0
TVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGvdCDIDVPKTIQMVRSQRSGMVQTEAQYRF
|| .||. .|||||||...  .|..|..|..... . ...|||||||||.||||||...|||.. ....     .|. ......|.||.||||||.|| |
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleket..kevdifqivkelrkqRpgmvqteeqylf

IYMAVQ
.|.|..
lyrall
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 418-527 4.6e-18 60.1 In-house 216-345 (350) alignment 
Range on Protein: 418-527
Range on HMM: 216-345/350.0
TVWQYHFRTWPDHGVPSDPGGVLDFLE--------EVHHKQESIMDAGPVVVHCSAGIGRTGTFIVIDILID------IIREKGVDCDID------VPKT
 |.| ... |.| ..  .|  .|  ||         . ..      . |..||||||.|||||.. .| |.        .... .  |        .  .
vvyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisii

IQMVRSQRSGMVQTEAQYRFIYMAVQHYIE
.. .|.||  |||.  |. ||| |...| .
vnelrkqrismvqnldqfifiYeallfyfa
0038934 (Phosphotyrosine protein) phosphatases II 418-527 4.4e-13 44.8 In-house 78-178 (194) alignment 
Range on Protein: 418-527
Range on HMM: 78-178/194.0
TVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHKQESiMDAGPVVVHCSAGIGRTGTFIVIDILIDiirekgvdCDIDVPKTIQMVRSQRSGMVQTEAQYRF
   .|.   .||.|.. .   .|.||. |... .     | |.||| ||.|||||...  ..          ..... . |...|. | |....  ... 
agieylklpfpddgtvPsleillrfldlvdeflne.dpggvvaVHCkaGlgRtGtlvaaYLiyr........lgmsaeeAialfrekRpgaipnqdylea

IYMAVQHYIE
... ......
llkrykelrk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 418-526 1.3e-11 38.4 In-house 219-344 (349) alignment 
Range on Protein: 418-526
Range on HMM: 219-344/349.0
TVWQYHFRTWPDHGVPSDPGGVLDFLEEVHHK--------QESIMDAGPVVVHCSAGIGRTGTFIVIDILIDIIREKGVD-CDIDVPK--------TIQM
 ..|  .. |.| ..  .|  .|  ||   .              .  ...|||||| ||||... .|.|..|.     .   |...         ..  
ellqlqvknwldlslllnPisilqalevkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivne

VRSQRSGMVQTEAQYRFIYMAVQHYI
.| ||  |||  ||. .|| |. .|.
lrkqrismvqnlaqfiaiyealLkyf
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 421-527 1.3e-07 25.5 In-house 231-339 (347) alignment 
Range on Protein: 421-527
Range on HMM: 231-339/347.0
QYHFRTWPDHGVPSDPGGVLDFLEEVH-HKQES----IMDAGPVVVHCSAGIGRTGTFIVIDILID-IIREKGVDCDidvpKTIQMVRSQRSGMVQTEAQ
 |   ||| .  | |   || ..     .   |    .    |||| |  |. |. | ..  |.|. ..  |  |||    . .. .| ||.|.      
vyncttwpwkkypddekkvlalvrapvkesstslianleklapvvvmcdlgldrsatvvltsiiieqvldgktpdcd....dlfkkmrdqragvftmsif

YRFIYMAVQHYIE
| .   |   |. 
ytyairaalfylk
PTEN_1 422-519 3.7e-08 28.4 In-house 97-186 (196) alignment 
Range on Protein: 422-519
Range on HMM: 97-186/196.0
YHFRTWPDHGVPSDpGGVLDFLEEVHHKQESIMDAGPVVVHCSAGIGRTGTfIVIDILIdiirEKGVdcdIDVPKTIQMVRSQR-SGMVQTEAQYRFIY
|. . ..|||.||    ..|.......   |  . . |.||| ||.||.|| .|.  |.    .||     .. .....||..|  |....  | |...
ylhfpieDhgapsl.selfdicksfiewllsdpngnvVlVHCkaGlgRsGt.vvaayLm....ykgk...ltadeAlelvrekRppgapnspsqerlle
0048567 (Phosphotyrosine protein) phosphatases II 422-474 7.1e-06 20.5 In-house 40-95 (157) alignment 
Range on Protein: 422-474
Range on HMM: 40-95/157.0
YHFRTWPDHGvPSDPGGVLDFLEEVHHKQESIM-DAGPVVVHCSAGI---GRTGTFI
...  . |.| | . . . .|   .... ...    ....|||.||    |||.|.|
vyedfffdfG.PlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLi
PTPc_motif_SM00404 439-508 1.5e-06 23.1 In-house 69-124 (140) alignment 
Range on Protein: 439-508
Range on HMM: 69-124/140.0
VLDFLEEVhhkqesIMDAGPVVVHCSAGIGRTGTFIVIDIlidiIREKGvdcdIDVPKTIQMVRSQRSGM
||||.|..      . . | |.||| ||. |..|.|.  .    .|...    ... . ...|...|. .
vldfiena......ekkggkvlVHCqaGvSRSatliiaYl....mryrq....lslaeayefvkerRpii
subfamily_CDC14_pd Subfamily CDC14 453-519 1.6e-06 22.2 In-house 262-317 (328) alignment 
Range on Protein: 453-519
Range on HMM: 262-317/328.0
ImdAGPVVVHCSAGIGRTGTFIVIDILidiiREkgvdCDIDVPKTIQMVRSQRSGMVQTEaQYRFIY
.   | ..||| ||.|||||.|   ..    ..      .  . .|  .|  | |.| .  | .|..
a..eGaiavhCkaGLGrtGtLiacylm....kh....yrftaaeaiawlricrPGsvigp.qqkfle
DSPc Dual specificity phosphatase, catalytic domain 453-515 5.1e-06 21.4 Pfam-A 70-124 (133) alignment 
Range on Protein: 453-515
Range on HMM: 70-124/133.0
IMDAGPVVVHCSAGIGRTGTFIVIDilidIIREKGVdcdiDVPKTIQMVRSQRSGMVQTEAQY
. . . |.||| ||| |..|.|.      ....|..    .. . ...|...|| ..... . 
eqkgkkvlVHCqaGisRSatliiaY....lmktknl....slneAyefvkerrskispnagfl
DSPc Dual specificity phosphatase, catalytic domain 453-515 5.1e-06 21.4 In-house 70-124 (133) alignment 
Range on Protein: 453-515
Range on HMM: 70-124/133.0
IMDAGPVVVHCSAGIGRTGTFIVIDilidIIREKGVdcdiDVPKTIQMVRSQRSGMVQTEAQY
. . . |.||| ||| |..|.|.      ....|..    .. . ...|...|| ..... . 
eqkgkkvlVHCqaGisRSatliiaY....lmktknl....slneAyefvkerrskispnagfl
subfamily_DSP23_pd Subfamily DSP23 454-520 5.1e-06 21.2 In-house 82-140 (148) alignment 
Range on Protein: 454-520
Range on HMM: 82-140/148.0
MDAGPVVVHCSAGIGRTGTFIVIdiliDIIREKGVDcdidVPKTIQMVRSQRSGMVQTEAQYRFIYM
  .  | |||  | |||||..       ...|...       ..|  || .| | |.|  | . .. 
ekneavsvhcllgrgrtgtmlac....ylvkerkla....aaeaiaevrrlrpgsvetveqeklvrd
subfamily_CG42327_pd Subfamily CG42327 455-528 1.2e-17 58.5 In-house 246-317 (319) alignment 
Range on Protein: 455-528
Range on HMM: 246-317/319.0
DAGPVVVHCSAGIGRTGTFIVIDILIDIIREKgvDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIET
. ||.||||| |.||||. |  || |  . |      .|.|.... || .|.  |.|  || |||  .. | . 
sqGPlvvhcsdGvGrtGlviasdiairslees..krsvdiPqlvssvrrdrasavltkeqyefiykvlseyakk
subfamily_PTEN_pd Subfamily PTEN 457-521 3.5e-06 22.1 In-house 115-175 (184) alignment 
Range on Protein: 457-521
Range on HMM: 115-175/184.0
GPVVVHCSAGIGRTGTFIVIDILIDIIREKGVdcdiDVPKTIQMVRSQRSGMVQTEAQYRFIYMA
  ||||| || ||||. ||  .|   . ||      .. .  . .|.. .  |.  .| |...  
nvvvvHCkaGkGRtGvlivayllkslllekae....ealelfaeaRtknkkgvtiPsqrRYveYy
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 460-522 2.4e-11 37.8 In-house 2-61 (69) alignment 
Range on Protein: 460-522
Range on HMM: 2-61/69.0
VVHCSAGIGRTGTFIVIdiLIDIIREKGvDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV
|||||.| ||||||| |  .... | |  .  .|.   .| .|  |  ||  | .| ||. |.
vvhcssgtgrtgtfiai..mvemariks.eklvdifnnvqymrkcrpmmvmneieyifihdal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 460-522 3.1e-11 37.5 In-house 1-60 (69) alignment 
Range on Protein: 460-522
Range on HMM: 1-60/69.0
VVHCSAGIGRTGTFIVIdiLIDIIREKGvDCDIDVPKTIQMVRSQRSGMVQTEAQYRFIYMAV
|||||.| ||||||| |  .... | |  .  .|.   .| .|  |  ||  | .| ||. |.
vvhcssGtGrtGtfiai..mvemariks.eklvdifnnvqymrkcrpmmvmneneymfihdal
DUF1092 Protein of unknown function (DUF1092) 492-565 5.1e-06 11.9 Pfam-A 58-132 (270) alignment 
Range on Protein: 492-565
Range on HMM: 58-132/270.0
IDVPKTIQMVRSQRSGMVQTEAQYRFIYMAVQHYIETLQRRIEEEQKS-KRKGHEYTNIKYSLADQTSGDQSPLP
 . |..|.. ||| . ..|. |.   | .. .  . .|....|| ...   . ..|.. ...  .... .  |||
eekPerirvfRsqmktliqkaaeelgievepsRrtyaLkewleereeevYpqeegykalappsvalektppqpLP