Gene PTPN9 in Homo sapiens

Synonym: MEG2, PTPMEG2, PTPN9

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPN9
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP087_AA protein Get Run
HsapP087_AA_285-576 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
CRAL_TRIO_N CRAL/TRIO, N-terminal domain 20-68 1.4e-08 22.8 Pfam-A 1-55 (55) alignment 
Range on Protein: 20-68
Range on HMM: 1-55/55.0
EQATKQFLEEINKWT------VQYNVSPLSWNVAVKFLMARKFDVLRAIELFHSY
... |..|. . ...        ..  .|. .   .||.|||||| .||......
keklkellkalpdiikkkeevddkekekltDellLRFLRARkfdvekAikmLedt
CRAL_TRIO CRAL/TRIO domain 90-237 1.4e-33 104.3 Pfam-A 2-158 (159) alignment 
Range on Protein: 90-237
Range on HMM: 2-158/159.0
EILSGKFTILNVRDPTGASIALFTARLHHPHKSVQHVVLQALFYLLDRAVDSFET--QRNGLVFIYDMCGSNYANFE---LDLGKKVLNLLKGAFPARLK
|||.|.....  ||  |  . .. .... |.|. .. ....|...|.|.... |.  |..|.....|| | ......   ..| ||.|..|.  .| ||.
eileggkvgihgrDkngrpvlylrlgrfdpkklseeelvrllllvlerllklleedgqiegvtvviDmkglslskmlwkpisllkkilkilqdnyperlg

KVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKTS----EVTQHLPRECLPENLGG
|.||| || .|.| ..... .|..|.||.|.....|    ..... ..|.||..|||
kilivnaPklfkvafklvkpfldektreKikfvspsntpatlekyidpeqlpkelGG
CRAL_TRIO_2 Divergent CRAL/TRIO domain 100-240 5.2e-15 44.3 Pfam-A 7-145 (149) alignment 
Range on Protein: 100-240
Range on HMM: 7-145/149.0
NVRDPTGASIALFTARLHhphKSVQhVVLQALFYLLDRAVDSFETQRngLVFIYDMCGS-NYANFELDLGKKVLNLLKGAFPARLKKVLIVGAPIWFRVP
  .| .|  . .| |.     .| .  .   |.|||..  | ....    | .|...|  .  ...| ..||....|  ... .||||..| . ....  
ggkdregrpvvvfiakyl...pstd.dydkllkyllhtledeivgkp..yvlVyfhtglssenkpslswlkklyktlprrykknlkkvylvhpstflksi

Y-SIISLLLKDKV-RER-IQILKTSEVTQHLPRECLPENLGGYVK
.  . ||..  |. .   | | . || .... .. |.. |.| ..
lstllslfvskkflkkkviyisslseLseyiditqlkkslpgvys
subfamily_PTPN9_pd Subfamily PTPN9 286-580 1.2e-157 518.6 In-house 1-296 (297) alignment 
Range on Protein: 286-580
Range on HMM: 1-296/297.0
MTIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRD
..|.|||.||....|.|...||..||.|...|||..|....||||||| || |.|.|||.|.|.......|||||.|.||||||.|.|.|||||..|..|
keieelvayvkekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsd

FWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLR
||.|||||.|||||||||..| ||.|||||||||..|...||.|.|.|. ||....||...|||.|......|.|||||||||||||||||||||.|.|.
fWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvle

VVRNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFA-EKEGM
.||..|.|||...|...||.. .|||||||||||||||||..|||||..|||.||..|..||...||||||||||||||.|||.|.||.| |....
kvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalelkal
0043336 (Phosphotyrosine protein) phosphatases II 286-574 3.8e-97 320.3 In-house 5-276 (278) alignment 
Range on Protein: 286-574
Range on HMM: 5-276/278.0
MTIQELVDYVNARQKQGIYEEYEDIRRENPvGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRD
....... ....  |.....|.|.... .. .|. ....| | .|||| |....|..||||.  .|.  .||||||..|||......| |||||..|. |
kdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved

FWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPlekDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLR
|| ||||..| .||| |...| || || ||||   .. ...| .|||.|..| ...|. .|||..|. . ..|.|||...|.|||.|||.| ..|.|||.
FwrmvwelgvttivmLtelvelgrvkcaqYwp...ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflk

VVRNQQslavsnmgarskgQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF
.||...             . .. |..||||||.||||||. |...| |||  |.......|...|.||. ..|||.||.|.|.|.||.
avreal.............edsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 286-577 1.1e-87 289.1 In-house 5-285 (319) alignment 
Range on Protein: 286-577
Range on HMM: 5-285/319.0
MTIQELVDYVNARQ---KQGIYEEYEDIRRENPVgTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENT
. .||| ....| .   .... .|.....  ... ||. .  . | .|||| ..   |.|||.|..  |  ..|||||||.|||......| ||.|||||
ievqeLkerlkalastgetllekefkllkeavnd.tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

YRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKdsRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEE-RQKRQVTHFQFLSWPDYGVPSSAASLI
  ||| ||||... ..|| |.  | .. |. .||| |.    ..| |.|| .  |....| .  |....  .  . |.|.|||...||| .|| .| ||.
iedfWrmvWeeessivvmltklveklkvklkkywpeen..feeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatsll

DFLRVVRNQQSlavsnmgarskgQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEK
|.|. .|. ..            .  . |||||||||.||||||. ||. | ...| |.|.||.||||.|||| . .|.|||| |.|.|.||..| 
dllkrirksre............ktqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 286-575 4.8e-78 257.4 In-house 12-290 (298) alignment 
Range on Protein: 286-575
Range on HMM: 12-290/298.0
MTIQELVDYVNARQKQGIYEEYEDIRRENP---VGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENT
...|.|..  .. .  |  .|.. ... .      . . . .| | .|||| |.  ||..|| |.| ..  ..|||||||...||..||.| ||.||..|
aalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltet

YRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSriRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLID
  ||| ||.|... .||| |  || .. |. .||| |.    ..| .||. |  |..  . ...|......|...|.| ...| |||| |||. | |..|
vedFWrmvteedigtiVmltnleeldktkyhkywPdegke..tygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvld

FLRVVRNQQSlavsnmgarskgQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFA
.|| || .|.            |. . |..|.||||.||.|||. .|  | ....  .. |||.| ..|..|. ..|| ||| |.|.|.||. 
llrkvrasqq............qagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleal
subfamily_PTPRD_pd Subfamily PTPRD 287-576 3e-104 344.7 In-house 9-282 (564) alignment 
Range on Protein: 287-576
Range on HMM: 9-282/564.0
TIQELVDYVNARQKQGIYEEYEDIRREnPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDF
...| |  ..| ... . |||..|... .  |.. .  | | .|||| ..   |..||.|.|  |. ..|||||||.|||....||| |||||..| .||
elkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedF

WLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEkDsRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRV
| |||||.. .||| |. || |. || .||| . . . ..| ||||    |....|  .|...........|.|..|.| |||| ||| ||.||.|..| 
WRmvweqnsstiVmltkleEkgkvkchkYWPek.g.tetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirk

VRNQQSlavsnmgarskgqCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE
||. ..             . . |||||||||.||||||. .|..| ...| .|....|.|...|.|| . .||.||| |...||||. .
vralne.............pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheaileala
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 287-575 1.2e-62 206.9 In-house 6-288 (325) alignment 
Range on Protein: 287-575
Range on HMM: 6-288/325.0
TIQELV---DYVNARQKQGIYEEYEDIRRENPVgTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTY
.. .||   .  .|....|.  |.. .  .... ... .| | | .|||. .|  ||..|| |  .   ...||||||..  .|.|. .. .| || .| 
avvnlvehvekkkaqdqdgfahefgllpsddgi.akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltati

RDFWLMVWEQKVLVIVMTTRFEEgGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDF
 |.| .| . .  |.|..  ... |  .| .||| |     .|| | |    .|..  | .  |.. .... . | |  ||. ||.| ||.   |.|| .
ndlWrlvldWrcsvvvvlneldl.gkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisi

LRVVRNQQSlavsNMGARSKGQCpepPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFA
|..| . .      . | .|.     ||.||||||.||||.| ||   ||.. |   ...|. | ..| .|   ..| .|| ..|.|. |. 
lqlvkavse....rvtantkast...pilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 287-365 5.6e-07 23.2 In-house 7-85 (440) alignment 
Range on Protein: 287-365
Range on HMM: 7-85/440.0
TIQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDG
 . ...|||.  ..   .|.   .     .   . .  | |  |||| .. . |..|| | .  |  ..||||||...|
ivadfadyvqnnrrsrafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasying
0051299 (Phosphotyrosine protein) phosphatases II 288-575 2.1e-104 344.3 In-house 10-286 (288) alignment 
Range on Protein: 288-575
Range on HMM: 10-286/288.0
IQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFW
. .|| .. |... |..||.|.... .| .|..... | ||||||| |....|..||||.  .|.  .||||||..|||..|...| |||||.||. |||
llklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpntvedFW

LMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLekDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNT----EERQKRQVTHFQFLSWPDYGVPSSAASLIDF
 |||||.| |||| |...| ||.|| |||||  .. . .| .|||.| .| ...|...|||. |.     . ..|.||||....|||.|||.|. .|.||
rmvweqnvrvIvmltklvelgrekcaqYwpl..ggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldf

LRVVRNQQSlavsnmgarskgqCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFA
|| ||....              ...|.|||||||.||||||. ||..| |||. |...|...| |.|.|| ...||||||.|.|.|.||..
lrlvrkala.............sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
0040438 (Phosphotyrosine protein) phosphatases II 288-580 9.6e-102 335.7 In-house 5-281 (317) alignment 
Range on Protein: 288-580
Range on HMM: 5-281/317.0
IQELVDYVNARQKQGIYEEYEDIRRENPVgTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFW
. ... ...........||.||... ..  |. ... | | .|||| |....|..||||.  .|.  .||||||..||...|...| |||||.||. |||
lllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

LMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLekDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVV
 |||||.| |||| |..|| ||.|| |||||  .. . .| .|||.|..| ..... .|||. .... ..|.||||....|||.|||.|  .|.|||. |
rmvweqgvtvivmLteleelgrekcaqYwpl..getltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleav

RNQQslavsnmgarskgQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGM
|...             . |. |..||||||.||||||. ....| |||. |...|...| ..| ||. ..||||||.|.|.|.||.  . ..
real.............edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrklt
subfamily_PTPRB_pd Subfamily PTPRB 288-578 1.6e-83 275.1 In-house 12-288 (293) alignment 
Range on Protein: 288-578
Range on HMM: 12-288/293.0
IQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFW
..| |. ..|... .. ||||...  .   . ... .. | .|||| ..   |..||||.. ......|||||....||.... .| ||||| .|  |||
feehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfW

LMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSrIRFGFLTVTNLGVENMNHYKKTTLEIHNteERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVV
 ||||.|. .||| |.  |.|. || .||| .... . .| ..|| .  |.....   .|.|..  |...|.|....|.||||.|||.....|.||.| |
rmvwekkssiivmltqlvekgkvkCeeYWPadeep.vlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtv

RNQQSlavsnmgarskGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKE
|....            .. . |||||||||.|||||| .||  | ..||  ....| .|...|..|.. .|| .|| | ....|.. .|.
reaie...........ktaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 288-574 2.5e-66 218.7 In-house 8-278 (315) alignment 
Range on Protein: 288-574
Range on HMM: 8-278/315.0
IQELVDYV---NARQKQGIYEEYEDIRRENpVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYR
...|. ||   .|  |.|. ..|| |   . .  .. .    | .|||| ..   |..||.|     . ..||.||.|.|||..|. ||..|||. .. .
ldqlityvaqkkastkngfkqdyesipggq.lhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvk

DFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEkdsRIRFGFLTVTNLGVENMNHYKKTTLeiHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFL
||| .|.|...  ||| |   || .||. .||| .   .. .| .|||    |  ..|   ||    . . . |.|  ... |||| ||| .. .|... 
dfwrlvfeedigkivmltnlvegekrkaekywpdk...kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnli

RVVRNQQSLAVsnmgarskgqcpePPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF
| |.  .  .|              .||||||||.||||||..||  | |.|    ..|.. . ..| .|   .|. ||| | |.|.|| 
rtvkqhhtnsv.............gaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 288-573 1.9e-48 160.0 In-house 7-277 (439) alignment 
Range on Protein: 288-573
Range on HMM: 7-277/439.0
IQELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNL--EKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRD
.|| |. ..  ... . |..| |   .|  .  .|.   .    |||| ||  .| ||| | .  |  .. |||| ...|| ... || |||| ..|  |
fqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettdd

FWLMVWEQKVLVIVMTTRFEEGGRrkcgqYWPLEKDsrIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQK--RQVTHFQFLSWPDYGVPSSAASLIDF
|| .|.|.|.  ||| | . |  .     ||| ...  . .| ..|      .. .|    . . |  .. .  | | .|....|||  ||. |. ..||
fwrlviekktvtivmltnlvesyk.....ywpsdae..vcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldf

LRVVRNqqslavsnmgARSKGQCPepPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
|| .            |  | ..   |.|||||||.|||||  .|||.| ||     ...   |. .| ||   .|.  || | |.|.||
lrains..........andkeeyg..pvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle
subfamily_PTPN6_pd Subfamily PTPN6 289-578 3e-71 234.9 In-house 14-300 (306) alignment 
Range on Protein: 289-578
Range on HMM: 14-300/306.0
QELVDYVNARQKQGIYEEYEDIRRENPVGTFH--CSMSPGNLEKNRYGDVPCLDQTRVKLTkRSGHTQTDYINASFMDG--YKQKNAYIGTQGPLENTYR
.||    .  .|.|. ||.|....|.   ...   .  | | |||||  .   |.|||.|. ... ...|||||.....   .....|| ||| ||.|  
selekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvs

DFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIrFGFLTVTNLGVENMNHYKKTTLEI-HNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDF
||| |||...  ||||||.  | |. || .||| |....  .| ..|||.  .....|.  .| . ........|.| ...| |||| |||..   ..||
dFWrmvwqensrvivmttkevErgkekCarYWPdeeekee.yGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdf

LRVVRNQQSLAVsnmgarskgQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT---LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKE
|. |...|.            .  . ||||||||||||||||  .|| | ..|. |.   ... ..|  .|.||   .|| .|| | |||| .. |..
ledvnrkqeele.........eaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 289-576 2.2e-62 205.6 In-house 8-279 (287) alignment 
Range on Protein: 289-576
Range on HMM: 8-279/287.0
QELVDYVNARQKQGIYEEYEDIRR-ENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTkrsgHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFW
 |.|.  .|. ..|  . .  . . ..       .... | .|||. ..   |. || |      .. |||||.|.||||.|.|.| ...|. || |.||
gefvakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfW

LMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDsrIRFGFLTVTNLGVENMNHYKKTTLEIHNTE-ERQKRQVTHFQFLSWPDYG-VPSSAASLIDFLR
 ......| .||| .. .|  ...| |||| ||   . .|  ... |  | ...| . .||..|.. . .|.||. .|. .|.. | |.. ...|. . .
kliddrnvtaivmlcqekendeevcyqyWpeeks..vvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillviee

VVRNQQslavsnmgarSKGQCpepPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE
 ...|.           .|.    .||||||...||...||. .. . . .. |...||| . ..| |.  |.|| ||| | ....||. .
myktqr..........krgnt...sivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 289-582 6.9e-46 151.4 In-house 10-294 (305) alignment 
Range on Protein: 289-582
Range on HMM: 10-294/305.0
QELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHtqtDYINASFMDGYKQKNAYIGTQGPLENTYRDFWL
 ..|. .  .. .|. .|.  ..| | .  ...     . .|||| || |||. ||||     |   .|| | ..    . . .| || |||.|  ||| 
lkfvkrtlekgpaglraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvklegpwph...eyihanyvstptnpkrfictqaplektcadfwy

MVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFG----FLTVTNLGVENMNHYKKTTLEIHNTE------ERQKRQVTHFQFLSWPDYGVPSSAA
| ...||  | |   . | | .|| .|.. ...  . |      ..|     ....  |..  .. .|.        ..|.|||. .  ||| |||..  
mclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadl

SLIDFLRVVRNqqslavsnmgarSKGqcpepPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVF-QTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEK
.....|   |             |||     ||||||||||||||.   |.  | || .   ..   . . ..| ||  |||| .|| | .. ||.. .|
ailellekarp............skg.....pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrk

EGMVS
.... 
kklld
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 289-473 9.1e-20 65.3 In-house 63-235 (244) alignment 
Range on Protein: 289-473
Range on HMM: 63-235/244.0
QELVDYVNARQKQGIyeeyEDIRRENPVgTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSghTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWL
.|  ||.||   ||     ..| | .|   .. ...| |  ||| |    .|  || |.| |      ||||||.    .   || || || .|  ||| 
kegsdyinanyiqgs....qniirpdps.vmkdafnpnnswknregaglpfdfnrvplskgs..mgntyinasfvgclgrtaeyiltqhpladtsmdfwk

MVWEQKVLVIVMTTRFEEGgrrkcGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGV
|. |..| |.|.    ||       .|||  .        .|||    ...   | . |||    .  .. .| ||   ||  | 
mmlerhvnvlvvlgsveee.....deywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt
0050432 (Phosphotyrosine protein) phosphatases II 290-576 1.9e-106 351.1 In-house 31-300 (308) alignment 
Range on Protein: 290-576
Range on HMM: 31-300/308.0
ELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLtkrsgHTQTDYINASFMDGY--KQKNAYIGTQGPLENTYRDFW
 |  . .| ......||.|....  |.... ... | | .|||| |....|..||||     .  .||||||..|||  |.....| |||||.||. |||
llkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedFw

LMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKD-SRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRV
 |||||.| |||| |...| || || |||||| . . ...| .|||.| .|....|...|||. |... . |.||||....|||.|||.|...|.|||. 
rmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflel

VRNQQslavsnmgarskgqcPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE
||...               |..|||||||||.||||||. ||..| |||. |...||..| ..|.||....||||||.|.|.|.||...
vrksl...............pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylk
0045450 (Phosphotyrosine protein) phosphatases II 290-574 1e-95 316.3 In-house 16-303 (307) alignment 
Range on Protein: 290-574
Range on HMM: 16-303/307.0
ELVDYVNARQKQGIYEEYEDIRRENP--VGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGH-TQTDYINASFM--------DGYKQKNAYIGTQGP
 || .  .  ..|...|.|.......  .|.. ....| | .|||| |....|.|||||.  .|.   .||||||..        |||..|...| ||||
llvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgP

LENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEkDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNT-EERQKRQVTHFQFLSWPDYGVPSSA
|..|. ||| |.|||.| |||| |...| ||.|| ||||.| .. . .| .|||.|..| ...|. .|||.... .. . |.||||....|||.|||.| 
lpetvedFwrmlweqgvtvivmltelvelgrekcaqywPde.geeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsf

ASLIDFLRVVRNQQSLavsnmgarskgqC-PEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT---LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
..|.||.. ||. ..             . .. |..||||||.||||||. ....| |||. ||   ......|...| ||  ..|.||||.|.|.|.||
eelldfieevrkalee............lpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

F
.
l
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 290-580 2e-80 264.9 In-house 10-284 (288) alignment 
Range on Protein: 290-580
Range on HMM: 10-284/288.0
ELVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLM
. |   .||...|. |||. .   .   . . .  . | .|||| ..  .|..||||.|    ...||||||..||.|.|..|| ||||| .|  ||| .
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

VWEQKVLVIVMTTRFEEGGRRKCGQYWPlEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHntEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRN
|.|.|.  ||| | . |||..||..||| ..|   ..| .||| ......... . .|...   . .....|..|.|.||| ||| |.| |...|| | .
vyenktstivmltelveggktkCeeYWP.dadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkv

QQSLAvsnmgarskgqcpEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGM
...                 ||.||||||.|||||| .||  . ..||  ...|. ||...| |||. .|| .|| |.|...|. .|..|.
anqad.............tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieedgv
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 290-576 6.5e-78 256.9 In-house 8-284 (305) alignment 
Range on Protein: 290-576
Range on HMM: 8-284/305.0
ELVD---YVNARQKQGIYEEYEDIRREnpVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDF
.|      ... ...|. ..|. . .|    ...   .  | .|||. ..  ||. |..||... . ..||||||..||||.|..|| .||||.|| .||
dlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadf

WLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHN-TEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLR
| ...| || .||| |.  |||. || |||| .|  . .|| ..|.    .... | .  |.| .  |....|.|...|. .||| ||| .|.||.....
WrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslik

VVRNQQSlavsnmgaRSKGQcpepPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE
 |...|.        ..||.    |..||||||.||||.|...|| | .|.. ....||. . ..|..|   .|| .|| |.. |. |  .
rvqkdqk........kdkgv....pllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelit
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 291-577 8.6e-79 259.5 In-house 5-278 (281) alignment 
Range on Protein: 291-577
Range on HMM: 5-278/281.0
LVDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMV
 ..  .. ...|  ||||...  .   | . | .. | .|||| ..   |.||||.|. . ...||||||.|..|||....|| ||||. ..  .|| ||
hlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmv

WEQKVLVIVMTTRFEEGGRRKCGQYWPlEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIhNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQ
||||| .||| ||  |.|. || .||| ...|....| .||...  |. ..| . .... ..|. ..|.|.......||| |||.... |..| . |.. 
weqkvsaivmvtreieagklkChrYWP.ddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkl

QSLAVSnmgarskgqcpePPIVVHCSAGIGRTGTFCSLDICLAQL-EELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEK
..                 |.|.|||||.|||||. .||  . .. .|| .|.| ..|  .| .| . .||  || | |||.|.  .|
tekktk............aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 291-574 1.3e-49 163.6 In-house 5-292 (301) alignment 
Range on Protein: 291-574
Range on HMM: 5-292/301.0
LVDYVNARQKQGIYEEYEDIRRENPVGTfHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSG--HTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWL
|  .| | ..... |.|........  . . ..|  | . ||. ..  .|. |. |.. .    .|..|||||..|||..|...| .|||...| .||| 
lgthvaakhsnkfeeqykelkegedksc.tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWr

MVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNH---------------YKKTTLEIHNTEERQKRQVTHFQFLSWPDYGV
..|..|.  ||| |  .|| . || ||||  . .. .||..|||     ..                  ...  ... ..... ..|. .|  .||. ||
liwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGv

-PSSAASLIDFLRVVRNQQSLavsnmgarSKGqcpepPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAIL
 .  .  |     |.  ||.         ..|     |.|||||....|.|..||..| | |    |  .||| . ..| ..   ..| ||| . |..| 
vreprtvLqviddvihrqqki........ggg.....pvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvid

EF
..
my
subfamily_PTPRG_pd Subfamily PTPRG 292-577 4.6e-79 261.1 In-house 10-290 (563) alignment 
Range on Protein: 292-577
Range on HMM: 10-290/563.0
VDYVNARQKQGIYEEYEDIRRENPVGTFHC--SMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQT-DYINASFMDGYKQKNAYIGTQGPLENTYRDFWL
|  . | ...|. ||.|.. .|    ....  |  | | .|||| ..   |..||||.. .|. .. |||||...|||....|.|.|||||..|  ||| 
vaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWr

MVWEQKVLVIVMTTRFEEGGRRKCGQYWPLekDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQ------KRQVTHFQFLSWPDYGVPSSAASLID
|.|||.| .||| | ..| ||||| .|||   |  ...| |.||    | .  | . || |.|.. ..      ...|..... .||| |||....  . 
miWeqnvaiivmitnlvergrrkcdvYWPk..desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLi

FlrVVRNqqslavsnmgarS--K----GqcpepPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE
|  |...            |  .    |     |||||||||.|||||.. ||  | |...  . |||... ..|.|| | .|| |||.| ..|.||   
f..vkks............saankaeaG.....PivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaia

-K
 |
sk
subfamily_PTPRA_pd Subfamily PTPRA 292-575 4.9e-77 254.0 In-house 23-298 (330) alignment 
Range on Protein: 292-575
Range on HMM: 23-298/330.0
VDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVW
..   | . . . ||.. .   .  .|.  .    | ||||. ..   | .|| |....|. ..|||||||.||||.|. .| .|||.|.|  ||| |.|
irirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiw

EQKVLVIVMTTRFEEGGRRKCGQYWPleKDSRIRFGFLTVTNLGVENMNHYKKTTLEIH----NTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVV
|||   ||| | ..|  . || ||||  ..  . .| ..|.   .. ...|    . ..    .|.|...|.|. | | |||| |||. .  ....|. |
eqksativmltelkerkeekcaqywP..deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkv

RNQQSlavsnmgarskgQCPEpPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF---A
....             |  . |||||||||.||||||. ||  |....  . ..||..|.|.|.||.  .|| ||| |.||..||.   .
kklnq............qsag.pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylyg
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 292-574 1.7e-65 216.0 In-house 9-276 (315) alignment 
Range on Protein: 292-574
Range on HMM: 9-276/315.0
VDYVNARQKQGIY-EEYEDIRrENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMV
  .||  ..  .. ||. |.  . ..   . .  . | .||||...  ||..||||     . . ||||||.. .... .||| .||||. .  ||| ||
pafvnknrhtalfseefhdlp.dPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmv

WEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEErqKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQ
...||  ||| |  .|| . || |||| .|   ..|| . |. | .|      .  | . ..||  .|.|| |||  ||| ||.  ..||. ... |. .
lqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssllklikevkad

QslavsnmgA-RskgqcpEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF
.          .      | ...||||||.|||| ..|.| ..||...  ...||..|  .|..| . .|| |.| | | |.|| 
n........gkk......efsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavled
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 292-577 2.4e-65 215.3 In-house 11-285 (290) alignment 
Range on Protein: 292-577
Range on HMM: 11-285/290.0
VDYVNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHT--QTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLM
|   .|....|  .... .   .   | .  ... | ..||. ..   |. |. | . |||   . .||||....|||.|..|| ||||..|| .||| .
vanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkl

VWEQKVLVIVMTTRFEEGGRRKCGQYWPLEkDSRIrFGFLTVTNLGVENMNHYKKTTLEIHNTEE-RQKRQVTHFQFLSWPDYG-VPSSAASLIDFLRVV
.|..|| .||| |   | |. || |||| . |..  .|  ... |  |..|.| ...||..|...  .|..||..|. .|.. | |.  ...|. . ...
iwqekvtiivmltniieegkvkCqqYWpds.dtka.ygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemy

RNQqslavsnmgaRSKGqcpEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEK
..|          | .|   . .||||||...||...||.... . . .  |  .||| . ..|.|.  |.|| .|| . .. .|.  ..
ktq..........rkrg...ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_CG7180_pd Subfamily CG7180 292-574 5e-56 184.5 In-house 6-289 (296) alignment 
Range on Protein: 292-574
Range on HMM: 6-289/296.0
VDYVNARQKQGI-YEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMV
...|. |.|  . |.    .  .   |.  . .   |.||||. .|   |..|| |.|  |. ..|||||...|.. .|..|| |..| ..|  .|| .|
lklvdkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlv

WEQKVLVIVMTTRFEEGGRrKCGQYWPLEKdsRIRFGFLTVTNLGVENMNHYKKTTLEIHNT----------EERQKRQVTHFQFLSWPD-YGVPSSAAS
.....  .|. |.  .  . .. .||| .   . ..| . |  . .... . |. |. .  .          .. ..| |..||.  |.    ||.|...
ydeeisavvvLtktfdfak.mypsywpnks..keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstna

LIDFLRVVRNQQSLAvsnmgarsKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF
||...| ||  .  .        . .  | |.||..| | .|.| ....|..| ..|. . ..||. | ..| .|   ... |.| ..|  .||.
lielrrrvrlwrekv........dedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 294-578 5.8e-24 79.0 In-house 19-288 (302) alignment 
Range on Protein: 294-578
Range on HMM: 19-288/302.0
YVNARQKQGIYEEYEDIRReNPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTkrsgHTQTDYINASFMDGYKQKNAYIGTQGPLENTY---RDFWLMV
.|.  ... . .|.. |     | . .|..   ||.||.  |||.||...|||.    ... .|.||| ..  . ..  | .| |  ..     .|| ||
lvksldtaevkkefkkidt.mkvdlekCkafkknlkknqsedvpildsnlvkle....aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmv

WEQKVLVIVMTTRFEEGGRrKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYK-KTTLEI--HNTEERQKRQVTHFQFlsWPDYGVPSSAASLIDFLRVV
...|.  .|.  . ||  .    ...|.. ..   .| . | |  ||...  | . ..|.  ..  .    .|.....  |..  || . |.||     |
fqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltn..Wkqkkvpvkyaeliktaakv

rnqqslavsnmgARSKGQCPEpPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKE
              .| .. | ..|.    |.|| |.| .| . . .|..    |. ..|  .|.||. .... .|| . | |.| .  |.
............fakkikade.ntvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk
0036941 (Phosphotyrosine protein) phosphatases II 295-579 1.7e-103 341.3 In-house 7-281 (297) alignment 
Range on Protein: 295-579
Range on HMM: 7-281/297.0
VNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLtkrsGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQK
 .. .......|.|.. .  . |.. ....|.||||||| |....|.|||||    ..  .||||||..|||..|...| |||||.||. ||| |||||.
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

VLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVEN--MNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQS
| |||| |...| || || ||||||... . .| .|||.|.||    ..|. .|||. .|.. ..|.||||....|||.|||.|.|||.||.. ||....
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlk

LAvsnmgarskgqCPEPPIVVHCSAGIGRTGTFCSLDICLAQLE---ELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEG
|.           ....|..||||||.||.|||. .|..| |||   . |.......|  .|.||....||.|||.|.| |.||.  |  
ll...........psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0039614 (Phosphotyrosine protein) phosphatases II 295-575 5.8e-94 310.1 In-house 26-289 (297) alignment 
Range on Protein: 295-575
Range on HMM: 26-289/297.0
VNARQKQGIYEEYEDIRRENPvGtFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGH-TQTDYINASFMDGYKQ-KNAYIGTQGPLENTYRDFWLMVWE
 .| .|.....|.|.. . .|   . ....| | .|||| |....|..||||.   |.   .||||||..|||.. ....| |||||..|. ||| ||||
ekansktllllefeellslkp.d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmvwe

QKVLVIVMTTRFEEGGRrKCGQYWPLEKDsriRFGFLTVTNLGVENMNHYKKTTLEIHNteERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQS
|.| |||| |...| || || |||| | .   ..| .|||.|.||  ..|. .|||. |  . . |.|||||...|||.|||.|...|..||. ||....
qgvtvivmLtklvelgr.kcaqywpeegg...tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvreala

LAvsnmgarskgqCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFA
 .            .. |..||||||.||||||. ....| |||. |...|...|...| ||  ..|||.||.|.|.|.||. 
el...........pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_Ptp69D_pd Subfamily Ptp69D 295-577 5.3e-78 257.2 In-house 16-288 (307) alignment 
Range on Protein: 295-577
Range on HMM: 16-288/307.0
VNARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQK
 .   ..|. .||| . ...   . . |    |. |||| |.   |.|||||.|  |. ..|||||||. |||.|. .|  |.|.|.|  ||| |..||.
rkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqe

VLVIVMTTRFEEGGRRKCGQYWPLEkdSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTE-----ERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRN
| .||| .  .|  |.|| .||| |    ...| . |.    |....| . .|.. ...     . ..|.|. .....|.|. || .| .|..... ||.
vtlivmlsnlteknrkkcakYWpie..devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvre

QQSLAvsnmgarskgqcpEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEK
 ..|              . ||||||||| ||.|.| .||. | ||..  ....|.||  .| || . .|  ||| |.|.|.|.. ..
lykln.............rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssy
subfamily_PTPRK_pd Subfamily PTPRK 295-573 2e-69 228.8 In-house 16-275 (314) alignment 
Range on Protein: 295-573
Range on HMM: 16-275/314.0
VNARQKQGIYEEYEDIRREnpvgtFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQK
... .  |. |||| .        . ..    | ||||.||.   |..||.|.   | ...|||||...|.||. .|.| |||||..| .||| .|....
lkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvyden

VLVIVMTTRFEEGGRRKCGQYWPleKDSRIrFGFLTVTNLGVENMNHYKKTTLEIHN--TEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQS
   ||| | . | || || .|||  .|... .| . |. . .|  . . . .. ...      ..|.| .||||.|||..|| || .|....| | ..| 
casivmltelvevgrvkClkyWP..edtev.ygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqe

LavsnmgarskgqcPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
               . .|||||||| ||||||. .|| |  .|. |...||..|  .|...   ..| ||| |.| .|||
e.............eaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 295-573 3.8e-46 152.2 In-house 13-234 (392) alignment 
Range on Protein: 295-573
Range on HMM: 13-234/392.0
VN-ARQKQGIYEEYEDIRrENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQ
|.  |.   ..||. |.  . ..    ..  . ||.||||...  .|..||||      ...||.|||.........||| .|||   .  ||| ||...
veknrhsalffeefhdlp.gpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqe

KVLVIVMTTRFEEGGrrkcgqywplekdsrirfgfltvtnlgvenmnhykkttleihntEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQqsl
.|  |.| |...||                                                ..| |. |.|  ||| .||  ..||. |.. |. .   
nvttiamvtklkegd............................................kgddartvaqfhftewPdkdvpkhtssllkfikevkad...

avsnMgarskGQCPEpPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
          ||    |...|||||.||||   |.|  .|. ..   ..||. |. .| .| . .|| ||| | | |.||
....f.....Gqyth.pliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 295-573 1.6e-35 117.6 In-house 13-269 (288) alignment 
Range on Protein: 295-573
Range on HMM: 13-269/288.0
VNARQKQGIYEEYEDIRRENPVGTFHCSMspGNLEKNRYGDVPCLDQTRVKLTkrsgHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQK
|     .|.  ||.|   |... . .  .  .|  ..|| ..|. | |||||.         ||.|  .   | |.  | .| ||. |   .| |. |. 
vlqiaveglkkeyrdspneasidiidsfi..anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesd

VLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFG-FLTVTNLGVENMNHYKKTTLeIHNTEERQKRQ-VTHFQFLSWPDYGVPSSAASLIDFLRVVrnqqs
|  ||| ... | |..|  .|.|...  ..|.| . ||.    .....  | .| .....| .... | .  .| |.| ||| .  | . .| |.     
veyivmlcellekGkeksaeyfPsklGekarigrlctvvkkkradidklvkvsl.lriskegeekvivkilhlleWdddgvPenylsplrllevl.....

lavsnmgaR---SkgqcpepPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
        .           |||||.|||.|||||.    | | .|     | . . ....| .|  .|||  || . .. .||
........kslqk.......PivvhssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvle
0047943 (Phosphotyrosine protein) phosphatases II 296-574 8.5e-102 335.5 In-house 7-271 (273) alignment 
Range on Protein: 296-574
Range on HMM: 7-271/273.0
NARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLtkrsGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKV
.. ......||.|....  |..|. ... | |..|||| |....|..||||    |.  .||||||..|||..|...| |||||.||. ||| |||||.|
kllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnv

LVIVMTTRFEEGGRRKCGQYWPLEKDS-RIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLA
 |||| |...| ||.|| |||||| ..  ...| .|||.|..|. ..|...|||. |..  ..|.||||....|||.|||.| .||..|...||.... .
rviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkaleal

VSNmgarskgqcpePPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF
.||           .|.|||||||.||||||. ||..| |||. |...|...| ..|.||  ..||||||.|.|.|.||.
psn...........gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 296-574 1.3e-58 193.1 In-house 5-276 (287) alignment 
Range on Protein: 296-574
Range on HMM: 5-276/287.0
NARQKQGIYEEYEDIRREN--PVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRsGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQ
. | |. . .|.. ....      ||. .    . .||||.||  .|.||| |..  |.  .||||| .. .|....|.| .|||.  | |||| .|.|.
errvkddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsae.gelGsdyinanyvasytddeafiaaqgPiaatvrdfwravlet

KVLVIVMTTRFEEGGRRKCGQYWPlEKDSRIRFGFLTVTNLGVENMN-HYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQS
.. .... ||  | .| || .||| |..  .| |  .|. |  .... .|   .| . . | |. | |  ...||||| ... .| .|| |   |...  
rsasvitmtreveearlkcykywP.erevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhie

LAVSNMGArskGqcpepPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF
|| .  ..   |     |.|||...||||.|.. .. ... .||.|| ..| ..| |.| .||  .|.. |. . |.|.  .
lardasev...G.....PlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 297-576 4.1e-87 287.2 In-house 16-281 (318) alignment 
Range on Protein: 297-576
Range on HMM: 16-281/318.0
ARQKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVL
.  .  . |||| . |..   | . |..| |  |||| ..   |.|||||....|....|||||...|||..|.||| .|.|| .| .||| |||||.  
esGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsa

VIVMTTRFEEGGRRKCGQYWPLEKdsRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSlavs
|||| |. || |..|. .||| ..   . .| |.|.     ....|   ......||| ..|||  ... |||| |||.|.|||.|..| |.. |     
vivmltqeeergkakvhryWPskg..srsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqq....

nmgarskgQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE
        .. . |||||||||.||||.|. .|| | .... ....|||||...|.||   .|| .|| |.|...||. .
........ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvlleala
subfamily_PTPRN_pd Subfamily PTPRN 298-573 2.2e-52 172.6 In-house 26-290 (297) alignment 
Range on Protein: 298-573
Range on HMM: 26-290/297.0
RQKQGIYEEYEDIRR-ENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASF-MDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKV
..|. . .|.| . . |.   | . . .. |..|||. .|   |..||||.... ....||||||. .|   .. ||| ||||| .|  ||| ||||| |
knkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGv

LVIVMTTRFEEGGRRKCGQYWPLEKDSrIrFGFLTVtNLGVEN--MNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNqqsl
 |||. || || | ..| .||| |  . . ...  | .|  |    . |   .. . | . .. | || | |||||. |||.|| ||..| | |      
vvivnltrleeegvkqckrywpdeGse.v.yhiyev.hlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnk....

avSNMGaRSkgqCpepPIVVHCSAGIGRTGTFCSLDICLAQLEE-LGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
  |  | ||   |   |||||||.| ||||... .|. |..|   .  ...  |.  .| ||.  ..| .|. |...|. |
..syrG.rs...c...pivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPN13_pd Subfamily PTPN13 299-574 4.7e-70 231.0 In-house 9-268 (273) alignment 
Range on Protein: 299-574
Range on HMM: 9-268/273.0
QKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGhtqtdYINASFMDGY--KQKNAYIGTQGPLENTYRDFWLMVWEQKVL
..|   ||....|   |. | . . .  | .|||| .|   |.||||| . .|     |||||..     |..  || .|||| .| .|||.||||||. 
dqqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkae

VIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGF-LTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSlav
||.| |   |.|. || .||| .|....     |.|..|.|.... ..  .|.....| .. |.|.|..| .|||.|||||||.|. |.. ||. |.   
viamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt...

SNMgarskgqcpepPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF
..            ||||||||||||.||. ..|. |  .|    ..| ..| ..| ||   .|| .|| |.|||||| 
dag...........PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 299-573 1.2e-55 183.4 In-house 5-293 (297) alignment 
Range on Protein: 299-573
Range on HMM: 5-293/297.0
QKQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLtkRSGHTQTDYINASFMDG--YKQKNAYIGTQGPLENTYRDFWLMVWEQKVL
... . .|.. . .|.  ..|  .  .. | |||| |.   |.|||||  . . |..||||| ..     ...  || .||||..|  ||| .|.|| | 
drkeleaekdllldeargesfssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvr

VIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNhYKKTT-LEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDF-L----RVVRNQ
|||| ....|.|| ||  |||  .. | . | . |  |     . ...    |..     ..|.|.| |||||||.||||    |  |       ..   
vivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsde.fdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavp

QSLAVSN---------MGArSKGQCPE-PPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
  ||. .         . .  . . |   ...||||||.||.|     |. ||.|      .|   .| .| |||  .|| ||. ..|.|.|.
mmlalvemftamvflqles.lraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 299-577 2.1e-42 140.0 In-house 4-261 (267) alignment 
Range on Protein: 299-577
Range on HMM: 4-261/267.0
QKQGIYEEYEDIRRENPV-GTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKrsghTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLV
... | .|.| |..  .   |  .|..  | |.||. |.   |.||| | .    .. .|||||...|||.|||.| ||.||.||  ||. .. .||| |
eeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrt....keeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpv

IVMTTRFEEGgrrKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERqKRQVTHFQFLSWpdyGVPSSAASLIDFLrvvrnqqslavSN
||. |.  ..   .  ..|| .     ..  |||     .. | |.  |||..  .|   ..|| . .  |    . .     .  |             
ivlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfknes.ahnvtlyyykkw...nintnnkpylkpl...........fg

MGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEK
. |. . .  ..|.||.||.|.||.|||  .|  | .. . |....|. . ..| ||   ..| |.| .... . |.|| 
ilaknqlengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyaeg
subfamily_PTPN14_pd Subfamily PTPN14 300-575 1.9e-68 225.7 In-house 22-296 (300) alignment 
Range on Protein: 300-575
Range on HMM: 22-296/300.0
KQGIYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKrSGHTQTDYINASFMDG--YKQKNAYIGTQGPLENTYRDFWLMVWEQKVLV
.  .. ||| | ...  ......  | | ||||. ||   ...||.|.  . ...|.||||| .      ..  || .|||||.| .||| |||||.| .
egkvfteyeripkkredallstaklpenaeknrfkdvlPyednrvelsp.tkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvql

IVMTTRFEEGGRRKCGQYWPLE--KDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVrnqQSLAV
||| |. ||.|. |. .|.| .  | ....||   ||.  .|. . .  |.|...    ...|.| |.|.  ||| |||.   . ...|. |   ||.  
ivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeev...qsvrr

SNMGARSKgQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFA
     ..  .  .||..||||||.||||     |. .| ||   .... ....|.|.|| . .||  || | ||..... 
ktnseves.keskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 300-574 2e-47 156.7 In-house 15-276 (307) alignment 
Range on Protein: 300-574
Range on HMM: 15-276/307.0
KQGIYEEYEDIRRENPVGTFHCSMSpGNLEKNRYGDVPCLDQTRVKLTKrSGhTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIV
 | . .|.. . . .| |    ..|  | .|||| ||.| |..|. ..  .|   .||| | ..    . . .| .|||||||  .|| |. ..||  ..
vqalvdefrvlakktpegvtveafs.antdknryqdvkcqdkgrivvkf.dg.lasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvi

MTTRFEEGGRRKCGQYWPLEKDSRIRFG----FLTVTNLGVENMNHY----KKTTLEIHNTeeRQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQ
|  .  | .. || ||||||.  .  ||     ..|.|||....       . |||..  .  .. | ..|.|.  ||| |||    . |..|  || ..
mlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwa..qksrtiqhlqwenwpdrgvpqinltainlleavrydt

SlavsnmgarskgqcpepPIVVHCSAGIGRTGTFCSLDICLAQ-LEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF
                  |.|||||||.||.||  .. .   . ..     .. . |  .|.|| ..|||  || . .. .||.
n.................pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_CG42327_pd Subfamily CG42327 300-491 5.2e-37 122.2 In-house 4-195 (319) alignment 
Range on Protein: 300-491
Range on HMM: 4-195/319.0
KQGIYEEYEDIRrenPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQ-KNAYIGTQGPLENTYRDFWLMVWEQKVLVI
.. ..||..|.     . .    . ..  .|.|. .|  | .||| | . . . .. |..||.. ||.. .| ||..| .||..  ||| .||||.  ||
redvaeefrdlP...qliaradevPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvi

VMTTRFEEGGRRKCGQYWPLEK--DSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFlSWPDYGVPSSAASLIDFLRVVRNQ-Q
|  |   | | ..| .|.| ..  |..  .| . ||  | |  ..|  .|| ... .. . |..||. .  |.. .||.. |.||  |  ||.  .
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevrsslk
0046845 (Phosphotyrosine protein) phosphatases II 302-576 2.5e-100 330.8 In-house 1-275 (284) alignment 
Range on Protein: 302-576
Range on HMM: 1-275/284.0
GIYEEYEDIRRENPVG--TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGH-TQTDYINASFMDGY-----KQKNAYIGTQGPLENTYRDFWLMVWEQ
|..||.| ... ..    ...... | ||.|||| |....|..||||.  .|.   .||||||..|||     ..|...| |||||.||. ||| |||||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KVLVIVMTTRFEEGGRRKCGQYWPLEkDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTE-ERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQS
.| |||| |...| || || |||||| .. ...| .|||.| .|....|...|||. |.. . . |.||||...||||.|||.|...|..||| ||....
nvrvIVmltelvengrekcaqYwple.gevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrelle

LavsnmgarskgQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELG---TLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE
              ...|||||||||.||||||. ||..| |||. |   ...|...|.|.|.|| ...||.|||.|.|.|.||.. 
n...........lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
DSPc_SM00195 303-575 4.7e-94 309.9 In-house 2-262 (263) alignment 
Range on Protein: 303-575
Range on HMM: 2-262/263.0
IYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTT
. ||.|.......  .....  . | .|||| .... |.|||||.|. .....|||||....|...|..|| |||||..| .||| ||||.|| .|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMN-HYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAvsnmgar
..|| |..|| .||| |...  .|| ..|..  ||... .....|||. .......|.||..|. .||| |||.|. |....||.|....|         
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......

skgqcpEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFA
      ..|||||||||.||||||...||.| .|||  ....|..|...|.||. ..|| ||| |.|.||||..
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 303-575 4.7e-94 309.9 In-house 2-262 (263) alignment 
Range on Protein: 303-575
Range on HMM: 2-262/263.0
IYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTT
. ||.|.......  .....  . | .|||| .... |.|||||.|. .....|||||....|...|..|| |||||..| .||| ||||.|| .|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

RFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMN-HYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAvsnmgar
..|| |..|| .||| |...  .|| ..|..  ||... .....|||. .......|.||..|. .||| |||.|. |....||.|....|         
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.......

skgqcpEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFA
      ..|||||||||.||||||...||.| .|||  ....|..|...|.||. ..|| ||| |.|.||||..
......sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
0045098 (Phosphotyrosine protein) phosphatases II 303-575 6.3e-88 290.0 In-house 9-272 (278) alignment 
Range on Protein: 303-575
Range on HMM: 9-272/278.0
IYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKltkrsghtqtDYINASFMDGYkqKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTT
.. |.| ... ...... ... .|||.|||| |....|..|||          ||||||..|||  ....| |||||..|  ||| |.||... |||| |
lllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmlt

RFEEGGRRKCGQYWPlEkDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNT----EERQKRQVTHFQFLSWPDYGVPSSA--ASLIDFLRVVRNQQSLAVS
...|.|| || |||| | .. ...| .|||.| .|....| ..||...|.    |. ..| |||...|.|||.||||.   .|....|. .|. ..|..|
elvelgrekcaqywp.e.ggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllas

NMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLeElGTLNVFQTVSRMRTQRAF-SIQTPEQYYFCYKAILEFA
 .. .   . .. |..||||||.|||||.. ....| .| | |.......|. .|.|| . ..|..|||.|.|...||. 
lllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell.e.ggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_PTPN3_pd Subfamily PTPN3 303-577 7.5e-74 243.1 In-house 17-277 (280) alignment 
Range on Protein: 303-577
Range on HMM: 17-277/280.0
IYEEYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKrsghTQTDYINASFM----DGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVI
.  ..| . | .|  . ...  | ||.|||| |.   |.|||||..    ..||||||...    .. .. | || |||||..|  ||| ||||||. .|
vlaqfeqlyrkkpglaisaarkpenlsknryrdilpydatrvklke....setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssli

VMTTRFEEGGRRKCGQYWPLEKDsRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQslavsnm
|| |   | || || |||| ..| ....| ..|.    .. . |    | ....|....|.....|.|.||| |||...|....|.. ||...       
vmlttlverGrvkChqyWPeted.eleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr.......

garskgQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEK
      .  | |.|||||||||||| .  |...|| .|.   ... . |..|| |||  .||..|| |  .|||.  |.
......sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_PTPN1_pd Subfamily PTPN1 303-576 8.4e-68 223.2 In-house 7-272 (290) alignment 
Range on Protein: 303-576
Range on HMM: 7-272/290.0
IYE-EYEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKrsghTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMT
 |.  |.|||.|    . . .  | | ..||| ||   | .|.|| .    ...||||||...  . |  || ||||| ||   ||.||||||   .|| 
lykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikler....adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvml

TRFEEGGRRKCGQYWPLEKD-SRIRFG--FLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAvSNM
 .. | .. || |||| ... . . .    |.|. .  |. ..|.  .||..| . .. |...|| ...|||.|||.| |....||  ||.  ||. |..
nkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsls.sdv

GarskgqcpepPIVVHCSAGIGRTGTFCSLDICLAQLEELGT---LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE
|          | |.||||||||.|||| .| ||...|. .    ... ...  .| .|   |||..|  | | |||| | 
G..........pavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 303-578 1.6e-50 166.4 In-house 29-286 (290) alignment 
Range on Protein: 303-578
Range on HMM: 29-286/290.0
IYEEY-EDIRRENPVGTFHCSMSPGNL--EKNRYGDVPCLDQTRVKLTKrsGhTQTDYINASFMDGYKqkNAYIGTQGPLENTYRDFWLMVWEQKVLVIV
.  || | ..   ||. .  ..   |   .|||| ||.| |.||| |    |  . ||. | ...| |    .| |||.|..|  |.| || ..|| .||
lakeyleklkpylpvqylerkifdkntefkknrykdvvcndktrvilkd..G.ydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaiv

MTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTN-LGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQslavsnm
|     | |. || ||.| ..   . || .||.  .  .. .. .| || . . .. .. .. |..  ||||  |. |. .|.  ||..|.         
mlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrkas.......

GarskgqcpepPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKE
|          |.|||||||||||||| .....|  | .   |.. ..|  .|  |. |.|   ||    ...|..  . 
G..........pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdf
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 304-377 9.7e-12 38.9 In-house 26-95 (95) alignment 
Range on Protein: 304-377
Range on HMM: 26-95/95.0
YEEYEDIRRENPvGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSghtQTDYINASFMDGYKQKNAYIGTQG
 .|.  |       .. .  |  |. |||. ..   | ||| || .    ..||||| |.||| .||.|| .||
dnefksismtsg.apytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 307-575 3.1e-44 145.7 In-house 17-269 (281) alignment 
Range on Protein: 307-575
Range on HMM: 17-269/281.0
YEDIRRENPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTK-RSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFE
. ..  . |     .   | | .|||| ..|||| .||.|      .  |||| | ..     |  || |||| ..|  ||| |.|...   |||  .| 
fsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfl

EGGRRKCGQYWPLEKDSRIRFGFLTVTNLGvENMNHYKKTTlEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRnqqslavsnmgARSKgq
|  | || .|.| .    ..|  |.|.      .|.   ||  .  . | . | .||. .  |||. || |.  ..  || .|           |||   
etnrekcaeyfprnahcclqfdklsvsyed.stvnkslvtt.rlnlsyegetrlithwlwkewpdwqvpessevmlkilrkir...........arst..

cpePPiVVHCSAGIGRTGTFCSLDICLAQLEELGTL-NVFQTVSRMR-TQRAFSIQTPEQYYFCYKAILEFA
   || |.|||||.||.||. ...|.|  .    || .. | ||..| | || |.|| .|| . .| .|.| 
...pp.vihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfg
subfamily_eak_pd Subfamily eak 309-575 1.7e-22 74.3 In-house 34-305 (332) alignment 
Range on Protein: 309-575
Range on HMM: 34-305/332.0
DIRRENPVGTFHCSMSPGNLEKNRYGDVPClDQTRVKLTKrSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGG
|. . ... . . .    ....| .. ||  |.  |.||  |   .  ||||| ..  .  . || |  . |.    || || |||   ||.     | .
dlddyqrllsisetarleavnrnvvkivpy.drylvrlts.sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelk

RRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERqkRQVTHFQFLSWPDYGVPSSAaSLIDFLRVVRNQQSLAVSNMGAR---S--K
  |  .|.| .    ..||.| |.     . | ..   ||..  .|    .| |...  | .. .|     .. . .|...   | . .| .    |  |
leksdkyfpdktreelkfGildverkefvkrniletrllelskGnet..hrvlhykvfGwtettlpkye.dflalrkvmkevGvlllivmksallsstlk

G---QCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEEL--GTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFA
      |    .. .. |  |.|.|  .|. .  ...    .  | . . .....|  |. .  |. | |...|.. 
kyihtppsfapiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyl
subfamily_PTPN12_pd Subfamily PTPN12 311-578 7.2e-71 233.4 In-house 25-280 (290) alignment 
Range on Protein: 311-578
Range on HMM: 25-280/290.0
RRENPVGTfHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRR
..|. . | ... .. | .|||| |.   |..||.|.| ... . |||||.|. | ..| .|| .|||| .|  ||| |.||..| ..||  |  | |. 
kaekvyst.eagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkk

KCGQYWPLEKDSRIRFGFLTVTNLGVENMN-HYKKTTLEIHNTeeRQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSlavsnmgarskgqCPEP
|| .||| |......|| ..||.   ....  .   ||....   ...|.|. |.. .||| |||||| ||..... ||. |.               . 
kCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe.............seda

PIVVHCSAGIGRTGTFCSLDICLAQLEELGT---LNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKE
|.|||||||.||||| ...|.   .|..  .   |.||. | ..|.|||  .|| ||| . |||..|. .||
PlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 314-573 3.7e-66 218.6 In-house 48-289 (319) alignment 
Range on Protein: 314-573
Range on HMM: 48-289/319.0
NPVGTFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTrfeeggRRKCG
 .  .   .  . | .|||....   |...||| .  |   .|||||||..||..|. || .||||.||  ||| |.||...  ||. |      . || 
vnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcs

QYWPLEKDSRIRFGFLTVTnlGVENMNHYKKTTLEIHN-TEERQKRQVTHFQFLSWPDYGVPSSAaslIDFLRVVRNQQSLAvsnmgarSKGQCPEpPIV
|||||. . .   . . |.   ||. . |    .|. . ..|...|..| | || |||.||| ..   .|..|.|.. . |        || . .. .||
qywplkivikeerfkvkvd..sveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdyp...sdlmrlvkkvrhlt.......skenhra.niv

VHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
||||||.||||..  ||. | ...|   ..|...|  .| ||   .|   ||.|.| |.||
vhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
0040439 (Phosphotyrosine protein) phosphatases II 318-574 5.8e-88 289.9 In-house 2-245 (249) alignment 
Range on Protein: 318-574
Range on HMM: 2-245/249.0
TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWP
.. ... | |..|||| |....|..||||.  .|.  .||||||..|||..|...| |||||..|. ||| |.||... |||| |...| || || ||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

LekDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAvsnmgarskgqCPEPPIVVHCSA
|  .. . .| .|||.| || ...|. .|||..|... ..|.|.|.|...|||.|||.| ..|.||.. ||. .. .            .. |..|||||
l..ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleel...........pkggpvlVHCsa

GIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF
|.||||||. ....| |||. ........|. .|.||  ..|.||||.|.|.|.||.
GvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel
subfamily_PTPN23_pd Subfamily PTPN23 318-577 3.8e-69 227.7 In-house 34-282 (288) alignment 
Range on Protein: 318-577
Range on HMM: 34-282/288.0
TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTkrsgHTQTDYINASFMDGYKQK-NAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYW
 . ....  . ||||. |.   |..||||      .. |||||||. .       .| ||.||..|  ||||||.|||. |||| .  || |. |. .||
krsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdrYw

PLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGArskgqcpepPIVVHCS
| .|.   .|| |.||   |...... . .|...  .......|.| |. |||..|||.|  .|..|| .|... .    .. .         |.|||||
PedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrkskt.........PlvvhCs

AGIGRTGTFCSLDICLAQLE-ELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEK
||.||||.|. .   ...|| . | |.. | |||.|.|| |..|. ||. |.|.|.|| |..
aGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarr
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 318-575 5.6e-55 181.2 In-house 24-266 (283) alignment 
Range on Protein: 318-575
Range on HMM: 24-266/283.0
TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGhtqtDYINASFMD---GYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQ
   ....  | .|||. ..   || ||.|   |     |||||.|.     |||.. || .|.||..| .||| ||...|.  ||| |.. |. | || |
dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsq

YWPleKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNT-EERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQslavsnmgarskgQCPEPPIVV
|||  |.  . .| .|||       | . .  | ...    ...  ..|.|.  | .||  .   ||. | .|. .|.             . .. ||||
yWP..krGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqt.............eskkgPivv

HCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFA
|||.|||||..|...   . ..     ..||..|  || ||   .|| .|| . ....|| |
hCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqa
subfamily_egg_pd Subfamily egg 318-575 1.8e-36 120.4 In-house 31-270 (307) alignment 
Range on Protein: 318-575
Range on HMM: 31-270/307.0
TFHCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGgrRKCGQYWP
... ..|  |||| |   |.| | .||||  | |    |.| |  ..|    | .| .| || ||  ||| ||....|  ||| |   |    .|  |||
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

LEKDSRIRF--GFLTVTNLGVENMN--HYKKTTLEIhNTEERQKRQVTHFQFlswpDYGVPSSAASLIDFLRVVRNQqslavSNmgarskgqcpepPIVV
  ..  ...  | | ..||.|..     .. | | .    ....| . |.|     |.   |   | .  || .||      |.            |.||
kaesdslvtvpGslrienlkvdskadplfrvtklkl.vGgddeerflehwqg....dvnnssdvysplrvlrklrnl.....sk............pvvv

HCSAGIGRTGTFCSLDICLAQLEEL--GTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFA
..  |. ...|. ...| | .|         | ..|  .| .| .|.... .| | |. .| | 
qdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfff
0037934 (Phosphotyrosine protein) phosphatases II 319-574 1.3e-77 255.9 In-house 2-241 (243) alignment 
Range on Protein: 319-574
Range on HMM: 2-241/243.0
FHCSMSPGNLEKNRYGDVPCLDQTRVKLtkrSGhtqTDYINASFMDGYKQknaYIGTQGPLENTYRD----FWLMVWEQKVLVIVMTTRFEEGGRRKCGQ
|.....| ||.|||| |....|..||||   .|   .|||||........   .| |||||..|. |    || |.||... |||| |...| || || |
fsiallpenlsknrysdilpydhsrvkl...eg...sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPlekDSRiRFGFLTVTNLGVENMNHYKKTTLEIHNTE-ERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMgarskGQCPEPPIVV
|||   ..  ..| .|||.|..|....|. .||.. |.. . ..|.|.|...|.|||.|||.| ..|.|||. ||. .. ..| .        .. |..|
ywp...gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsll.....aldsggpvlV

HCSAGIGRTGTFCSLDICLAQLeelgTLNVFQTVSRMRTQRAF-SIQTPEQYYFCYKAILEF
|||||.|||||.. ....| .|    .......| ..|.|| . ..|||.||.|.|.|.||.
HCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
0042113 (Phosphotyrosine protein) phosphatases II 320-574 1.4e-86 285.1 In-house 2-242 (245) alignment 
Range on Protein: 320-574
Range on HMM: 2-242/245.0
HCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLe
 ... | | .|||| |....|.|||||.  .|.  .||||||..|||.... .| |||||..|. ||| |.||... .||| |..|| || || ||||| 
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.

kDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLavsnmgarskgqCPEPPIVVHCSAGI
 .. ...| .|||.|..|....|. .|||..|. . ..|.|.|...|.|||.|||.. ..|.|||. ||....             ... |..||||||.
.gesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalae............dsngpvlVHCsaGv

GRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF
||||||. ....| |||..........| ..| ||  ..|||.||.|.|.|.||.
gRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 320-573 2.7e-65 215.7 In-house 18-253 (284) alignment 
Range on Protein: 320-573
Range on HMM: 18-253/284.0
HCSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTrfeeggRRKCGQYWPLE
  .  . | .|||.|..   |...||| .  |   .|||||||. ||..|. || |||||.||  ||| |.||...  ||. |      . || |||||.
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywplk

KDSRIRFGFLTVTnlGVENMNHYKKTTLEIHN-TEERQKRQVTHFQFLSWPDYGVPSSAaslIDFLRVVRNQQSLAvsnmgarSKGQCPEpPIVVHCSAG
 . .   . . |.   ||. . |    .|. . ..|...|... | || |||.||| ..   .|..|.|.. . |        || . .. .||||||||
ivikeerfkvkvd..sveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdyp...sdlmrlvkkvrhlt.......skenhra.nivvhcsag

IGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
.||||..  ||. | ...|   ..|...|  .| ||   .|   ||.|.| |.||
vgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 321-577 2.4e-69 228.5 In-house 22-270 (274) alignment 
Range on Protein: 321-577
Range on HMM: 22-270/274.0
CSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQ-TDYINASFMDGYKQ-KNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPL
  . .|. .|||| ..   ...|| |...|.. . ..|||| .. ||.. ..||. ||||| ||  |||.|.....| ||||.|...|  ..|| .|.| 
eldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPd

EKDSR--IRFGFLTVTNLGVENMNHYKKTTLEIHNTEErqKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMGARskgqcpeppiVVHCS
..| .   |.| . ... .. . |.|. ..| ....|.  .|.|.|. . .|||  .| .| .|.|... |..... .  ....           |||||
aedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapv..........vvhCs

AGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEK
||||||| | . .|.. ||.| ....|...|. .| .|   .|| ||| . ..|. .....
aGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylkr
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 321-574 8.1e-65 213.8 In-house 37-275 (515) alignment 
Range on Protein: 321-574
Range on HMM: 37-275/515.0
CSMSPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEK
 .    | .||||...  .|..||||       . ||.|||.. ...  .||| .|||.. .  ||| .|....|  |.| |. .|| . |||.|||   
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkp

DSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEErqKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNqqslavsnmgarSKGQCPePPIVVHCSAGIG
   ..|| . |  . .|      | .|..   ..   | || |.|  ||| |||  . ||. ... |.             ..||    |...|||||.|
gdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevka............dhgqyt.hpliihcsaGvG

RTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF
||| ..|.| ..|. ..  ...||..|  .| .| . .|| ||| | | |.|| 
rtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavled
0049772 (Phosphotyrosine protein) phosphatases II 323-576 1.8e-48 161.2 In-house 42-281 (314) alignment 
Range on Protein: 323-576
Range on HMM: 42-281/314.0
MSPGNLEKNRYGDVPCLDqTRVKLtKRSGHTQTDYINASFMDGYkqkNAYIGTQGPLENTYRDF----------WLMV--WEQKVLVIVM----------
  . | .|||| |... | .||.| .. ..  .||||||..||.   ...| ||||||.|. ||          | ||  ....| .|||          
dlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladel

-----------TTRFEEGGrrkcgqywplekdsrirfGFLTVTNLGVENmnhykkttlEIHNTEERQKRQVTHFQFLSWPDYGVPsSAASLIDFLRVVRN
            ... ..|                  ...|. .|   .         |...  |. .|.. ..  . .||...| . . . .||.....
srLdaAlgKtpllildgng..................neptaadlellk.........eelydpelferlgikylripvpDgsap.lledfdeflefiee

QqSlavsnmgarskgqcPEPPIVVHCSAGIGRTGTFCSLDICLAQLeelgTLNVFQTVSRMRTQRA-----FSIQTPEQYYFCYKAILEFAE
  .              .. |..|||.||.||||||. ..... .|     ... ......| .|       .|...|||.|...|.||. .
a.d..............kggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 324-575 1.3e-71 235.8 In-house 6-242 (250) alignment 
Range on Protein: 324-575
Range on HMM: 6-242/250.0
SPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRkCGQYWPLEKDSr
 | |.||||| |.  ||..|| | | .|  ..|||||||..||....|.| |||||..|  ||| ||.|.|. .||| | ..| ..  . |||| ||   
kpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae.

iRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSlavsnmgarskgQCPEPPIVVHCSAGIGRTG
 ..| .||. |  |..  |.|..| . .... ..|.| ...|..||| |||  | . ...|. |. .|             |. . |..|.||||.||.|
.kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqq............qagnaPvivqCsaGvgrsG

TFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFA
.|. .|  | .|..  ...||. . ..|..|  .... ||| |.|..||.. 
afiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 325-583 3.3e-33 109.6 In-house 50-298 (310) alignment 
Range on Protein: 325-583
Range on HMM: 50-298/310.0
PGNLEKNRYGDVPCLDQTRVKLTKRSGhTQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKdSRI
  .. |||| || |||..||||.        ||| | ..     ....| .||||. |  ||| |.....   |..  .  | || ||  |||       
kkymhknrysdvvcldtsrvklkidks.ryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslg.vte

RFGFLTVTNLGvENMNHYKKTTLEIH----NT--E----ERQKRQVTHFQFLSWPDYGVPSSAASLIdflrvvrNQQSLAvsnmgarskgQCPEPPIVVH
 .| . ||||. |  . ..   | .     |   .    . .. .|.  ..  ||| |||      .        |. ||          |    | |||
tygcirvtnls.esseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtv.......pqrlla..........qvrhgpcvvh

CSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSS
||||..|... ..|.. . .|..   ... . .. .. .||  |||. || .  .  . ||  |  |. 
csagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifargetevae
subfamily_ptpA1_pd Subfamily ptpA1 326-536 2.3e-39 130.3 In-house 46-257 (418) alignment 
Range on Protein: 326-536
Range on HMM: 46-257/418.0
GNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQKNaYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKD----
 |  |||| ..  ...|||.| |   .  .||||| ..||   |. .| ||||| ||  ||| ||||... .||| .|  |  | || .||| .      
hntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqiggeqf

-----SRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNMgARskgqcpEPPIVVHCS
         ||  .|  . | .    .  | .|. | | . |..|..|.  |||. .|  .  . ..|. . |.|   . .   |      . ||.||||
siygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipss.dr......nvpiivhcs

AGIGRTGTFCSLDICLAQLE
||.|||||||.  | . .|.
agvgrtgtfctavimmkkld
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 326-583 3.9e-39 129.3 In-house 34-278 (285) alignment 
Range on Protein: 326-583
Range on HMM: 34-278/285.0
GNLEKNRYGDVPCLDQTRVKLTKrsgHtQTDYINASFMD-GYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRI
 | . ||| || |...||| | .   | . ||| ||.|    |....|| ||||| .|  ||| |....|.  ..|   . |||  ||  |.| .    .
anpdlnryadvrcieetrvvlkn...h.drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

RFGF--LTVTNLGVENMNHYKKTTLEIHNTEERQKR--QVTHFQFLSWPDYGVPSSAASLIDFLRVVRnqqslavsnmgarsKGQCPEPPIVVHCSAGIG
.||   .|.|.   | .      .| . |||.       . | |   |||   |  |  .|.. . |.              | .  | ||.||||||.|
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvk..............kvnpkekpicvhcsagvg

RTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVSS
|| ||  .| .  .. |   ..... |  ||. |  ..|.  |. | |  ..|.   ||.|  
rtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegvver
Y_phosphatase Protein-tyrosine phosphatase 327-573 1.7e-86 284.8 Pfam-A 1-235 (235) alignment 
Range on Protein: 327-573
Range on HMM: 1-235/235.0
NLEKNRYGDVPCLDQTRVKLTKRSGHTQtdYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRF
|..|||| |... |.|||||....|...  ||||....|||.|...| |||||..|  ||| |||..|| |||| |. || ||.|| |||| |..   ..
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GFLTVTNL-GVE-NMNHYKKTTLEIHNTEERQ-KRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQslavsnmgarskgQCPEPPIVVHCSAGIGRTG
| ..|..   .. ....|  ..||.....|.. ||.|..... .|||.|||.|. ||.|..| |....             .  . |.|||||||.||||
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.............eaksgpvvVhCsaGvgRtg

TFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
||..|||.| |||. ....|.|.|...|.||. ..|. |||.|.||||||
tfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 327-573 1.7e-86 284.8 In-house 1-235 (235) alignment 
Range on Protein: 327-573
Range on HMM: 1-235/235.0
NLEKNRYGDVPCLDQTRVKLTKRSGHTQtdYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRF
|..|||| |... |.|||||....|...  ||||....|||.|...| |||||..|  ||| |||..|| |||| |. || ||.|| |||| |..   ..
nkkknRykdilpydktrvklkgsegpsd..YInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GFLTVTNL-GVE-NMNHYKKTTLEIHNTEERQ-KRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQslavsnmgarskgQCPEPPIVVHCSAGIGRTG
| ..|..   .. ....|  ..||.....|.. ||.|..... .|||.|||.|. ||.|..| |....             .  . |.|||||||.||||
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.............eaksgpvvVhCsaGvgRtg

TFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
||..|||.| |||. ....|.|.|...|.||. ..|. |||.|.||||||
tfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 327-575 2.3e-62 205.8 In-house 51-284 (297) alignment 
Range on Protein: 327-575
Range on HMM: 51-284/297.0
NLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQknAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRrKCGQYWPleKDSRIRF
|.||.|| ..   |. ||||  .  . . ||.||||. |.|.   .| || | ..|  ||| ||....| .||| .  .|. . || .||.  ...   |
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWs..dkgvttf

GFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPS--SAASLIDFLRVVRNQQSlavsnmgarskgQCPEPPIVVHCSAGIGRTGT
| ..|. | |.. . . | .||. . . ...| |  .||..|||  |.   ||.||....  ||.. |            |  | |..|||.||.|||| 
GdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfs............qnaegPllvhclaGvGrtgv

FCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFA
....| ..|. ..  ....|..|...| .| . .|| ||| | |.|.||. 
lltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleal
0041856 (Phosphotyrosine protein) phosphatases II 327-576 9.8e-52 170.5 In-house 1-172 (182) alignment 
Range on Protein: 327-576
Range on HMM: 1-172/182.0
NLEKNRYGDVPCLDQTRvkltkrsghtQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTrfeeggrrkCGQYWPlekdsrirf
||.|||| |... |..|            |||||....|.   . .| ||||| .|. ||. |..|... .||. |         . .|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

gfltvtnlgvenmnhykkttleihnteERQKRQVTHFQFLSWPDYGVPSsAASLIDFLRVVRNqqslavsnmgarskgqcPEPPIVVHCSAGIGRTGTFC
                           |. .|.......|.|||.|||.   .|.||.. |..                 .. |..||||||.|||||..
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.................eggpvlVHCsaGvgRtgtlv

SLDICLAQleelgTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE
 ..... .      ......|. .| .|  ...||.||.|.. |.||. .
aaylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 327-573 1.2e-50 167.0 In-house 3-237 (237) alignment 
Range on Protein: 327-573
Range on HMM: 3-237/237.0
NLEKNRYGDVPCLDQTRVKLTKRSGHtqTDYINASFMDGYKQ-KNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPlEKDSRIR
|  |||||.. . |..|| |    .   .|||||....|.    . || .|||||..  ||| |||..|  |||| | . || . || .||| . |    
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywp.stdqpaa

FGFLTVTNLGVENMNHYKKTTLEIHN-TEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQqSLAVSNMGarskgqcpepPIVVHCSAGIGRTGT
.| |||.    |..  |   .| . . .. .. | .  .|| |||| |||  .|.|. | . . |. |  ||. |          | ..|||||.|||| 
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinr.sphvsesg..........pwiihcsagvgrtgi

FCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
|  .|  | | .|   ..... |  .  .| . ||| .|| | ...|||
flvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 327-573 3e-47 155.8 In-house 7-238 (239) alignment 
Range on Protein: 327-573
Range on HMM: 7-238/239.0
NLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQ-KNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPlekDSRIR
|  |||| ..   |..|| | | |   ..||||||..  |    .||| ||| .| .  ||| |.|...  |||| | . || ..|| ||||   ||  .
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstsk

FGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRnQQSLAvsnmGARskgqcpepPIVVHCSAGIGRTGTF
.  | ||    | .  |   |. . .  . ..| | ...|  ||| |||  |.... . | .  ..||     |||        | |.|||||.||||.|
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslp....gar........pwvihcsagvgrtgaf

CSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
  .|  | | ..  |...|. |  .| .| . .|| ||| | . |.||
lvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 327-573 3.9e-47 155.4 In-house 8-239 (239) alignment 
Range on Protein: 327-573
Range on HMM: 8-239/239.0
NLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQ-KNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPlekDSRIR
|  |||| ..   |..|| | | |   ..||||||..  |    .||| ||| .| .  ||| |.|...  |||| | . || ..|| ||||   ||  .
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp...dstsk

FGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRnQQSLAvsnmGARskgqcpepPIVVHCSAGIGRTGTF
.  | ||    | .  |   |. . .  . ..| | ...|  ||| |||  |.... . | .  ..||     |||        | |.|||||.||||.|
ycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkit.kdslp....gar........pwvihcsagvgrtgaf

CSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
  .|  | | ..  |...|. |  .| .| . .|| ||| | . |.||
lvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 327-574 1e-42 140.8 In-house 55-288 (305) alignment 
Range on Protein: 327-574
Range on HMM: 55-288/305.0
NLEKNRYGDVPCLDQTRVKLTKRSghtQTDYINASFMDGY-KQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSR--
.  |||| |||| ||. ||| | |    .||| | ..      .. .| .||||..|  .|| || ..||  |||  .  | |. || ||||. .  .  
aitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgekle

IRFGFLTVTNLGVENMNHYKK---TTLEIHNTeERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRnqqslavsnmG--ArskgqcpepPIVVHCSAG
.. | .     |   |.   .   |.|..  .   ||  | |.|.  ||| |||    . ...|  .|          |            |||||||||
lksgivvenvsgskpmerdaeiqitllnltys.gdqkmsvrhlqwtewpdrgvppckltslellsair..........gskv.........pivvhcsag

IGRTGTFCSLDICLAQLEELGTL-NVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF
||||||  ...  | .. |      . . |  .| |||||||.  || | .. .|..
igrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 327-580 2.4e-23 77.2 In-house 47-284 (303) alignment 
Range on Protein: 327-580
Range on HMM: 47-284/303.0
NLEKNRYGDVPCLDQTRVKLTKRSghtqtdYINASFMDGYKQKNAyIGTQGPLENTYRDFWLMVWEQKVLVIVM---TTRFEEGGrrkCGQYWPLEKDS-
|..|||. || |||...|||.  |      || ||...   .|.| | || ||  |  ||| |. |||| ....    . ... |       .| ..|  
nmdknrfvdvicldhskvklsdss......yihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklg...gdsvfprnqdfl

RIRFGFLTVTNL-GVENMNHYKKTTLEIHNTEERQKRQVTHFQflSWPDYGVPSSAASliDFLRVVRNQQSLAvsnmgaRsKgQCPEPPIVVHCSAGIGR
..   .. | ..  || .. ..   | . | . .   .| |..  .||   .|| ...   |.. . . ||.       | |  ..  | |    .| ||
kfeersirvgefkrvelgdgwvlkvlsvsngdyksflhvhhyk..awphnsipsdgsp..kfvkqiwqlqsvl......r.k.ysdstptvymslsgcgr

TGTFCSLDICL-AQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGM
.|||. .. .  .  .|  .|.. . .  .|  |  ..|   |. . |  . |   ..|.
agtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldngi
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 327-412 7.8e-13 42.6 In-house 34-118 (332) alignment 
Range on Protein: 327-412
Range on HMM: 34-118/332.0
NLEKNRYGDVPCLDQTRVKLTKRSGhtQTDYINASFMDGYKQKNAYIGTQGPLEN-TYRDFWLMVWEQKVLVIVMTTRFEEGGRRKC
|.. ||   . |.|..||.|. . |  . |. |||..||| .|.||| .| |... |   || || |.|  .|..    .|  .||.
nmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrka
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 327-400 1.2e-10 35.4 In-house 37-115 (347) alignment 
Range on Protein: 327-400
Range on HMM: 37-115/347.0
NLEKNRYGDVPCLDQTRVKLTKR-SGHTQT----DYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVM
.|.|||  ||   |.||| |.   |  ...     ||||| .   . .. || || || .| |||| ||   ||  .| 
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvt
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 329-577 6.8e-68 223.6 In-house 22-266 (270) alignment 
Range on Protein: 329-577
Range on HMM: 22-266/270.0
EKNRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDGYKQ-KNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDS--RIR
. ||| |.    .|||.| . .   .| |||| .. |... |..|| ..|||..| ..|| |.||.||  ||||| .|| ||.|| .||| |...  ...
klnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvkle

FGFLTVTNLGVENMNHYKKTTLEIHntEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSNmgARSKGQcpEpPIVVHCSAGIGRTGTF
.|...|..|  |... | .| |...  |. ..|...||.. .||| |||... | ..   ...  . .  |.   . . .  | |..||||||.|||||.
dgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrse..keldka..e.PllvHcsaGvgRtGtl

CSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEK
  |||..  ||| . ..| . ....| .|   .|.|||| | |||..|.||.
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 329-566 5.9e-38 125.3 In-house 52-272 (301) alignment 
Range on Protein: 329-566
Range on HMM: 52-272/301.0
EKNRYGDVPCLDQTRVKLTKRsGhtQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGF
.|.||  |||  .| |.. .  |  .   | | ...   . . .| |||||.||  ||| |.   .|  ||| ... |   .|| .| |..  .... | 
dkhryptvPckPstavevivd.G..krvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

LTVTNLGVENM--NHYKKTTLEIHN-TEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNqqslavSnmgarskgqcpEPPIVVHCSAGIGRTGTF
 ...    | .  .. .| |||... |.. . | |||.|. .|.|.||| | | | |.. .|..      |           | ||||||||||||. .|
fkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkk......s...........ekPivvhcsaGiGrsvaf

CSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYF
 . ..   ..|   |... ... ..| .|  ..|| .| |.
igteylareveadptieltealkhlrehrwngvqtnsqlyw
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 329-581 9.7e-29 95.0 In-house 45-282 (312) alignment 
Range on Protein: 329-581
Range on HMM: 45-282/312.0
EKNRYGDVPCLDQTRVKLTkrsGHtQTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPL------EKDS
. ||| .. | |. |  |.   |  .  || | |.    . . .. ||||||||   || ..       |.. . | | |  || .|          .| 
dlnrypniqcwdrgrftla...gd.enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

RIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSlavsnmgarskgqcpepPIVVHCSAGIGRT
|.   . |  ..|    ..  .  | .      |. .. |.|. ||||.|.| |  .   .|  |....                  |.. |||||.|||
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.................pviahcsagvgrt

GTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMV
||.. ..  .| |      || ..   .| .|| |...  || .. ...|||   .|. 
gtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 329-426 8.1e-19 62.5 In-house 49-162 (350) alignment 
Range on Protein: 329-426
Range on HMM: 49-162/350.0
EKNRYGDVPCLDQTRVKLT--------KRSGHTQTDYINASFMDGY----KQKNA--YIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQ
 |||| ..   ...||||         |.  .   |||||...       ...    || ||.|| .|. ||. .. . || ||.. |   | ...|| .
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPLEKDS--RIRF
||.  . .   ...
YWqegsydditvkl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 334-577 1.8e-23 78.1 In-house 25-261 (290) alignment 
Range on Protein: 334-577
Range on HMM: 25-261/290.0
GDVPCLDQTRVKLTKRSGHTQTDYINASFMDgYKQKNAYIGTQGPLENT-------YRDFWLMVWEQKVLVIVMTTRFEEGGRR----KCGQYWPLEKDS
 .|| . .||| |     . . ||| |...  . .  . | || |.|..         .|| |. . ||  .||.  |||  .      | .| | . . 
levpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvge

RIRFGFLTVTNLGVENMNHYKKTTLEIHNtEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSlavsnmgarskgqcpepPIVVHCSAGIGRT
 ..|. |||     |. .  .. .|...  ..... .||| .. .| .  |. .  .|.. .. |.....                 |..|||  || | 
elkfkgltvkCkskekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvkaskt.................pvivHcvdGiSrs

GTFCSLDICLAQLE-ELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEK
 .. ....    .    | ... . .. .| |||  |...... |   .|.  | .
AalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagivllaie
0044763 (Phosphotyrosine protein) phosphatases II 338-573 2.9e-35 116.9 In-house 1-169 (178) alignment 
Range on Protein: 338-573
Range on HMM: 1-169/178.0
CLDQTRVKLTKRSGHTQTDYINASFMDGYkqknAYIGTQGPlentyRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDsrirfgfltvtnlgve
.|| |||.|....|.  .||||||.....     |.|...|      |.. ...|... .||. |   |.|. || .||| | .                
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

nmnhykkttleihnteerqkrqvTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQslavsnmgarskgQCPEPPIVVHCSAGIGRTGTFCSLDICLAQlee
                        ..... .||.|||.. . . .|.. ... .             . .. |..||||||.||.||.. ..... .   
.......................iqylhipipDhgvpdllehflefvefieeal.............dekggpvlVHCsaGvgRsgtlvaaylmkkl...

lgTLNVFQTVSRMRTQRAfSIQTPEQYYFCYKAILE
   |.... ....| .|   ...|.|....|.  |.
..glsleeaielvrerRp.ivpnpgqlrqLyefelr
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 348-417 1e-08 28.9 In-house 83-154 (349) alignment 
Range on Protein: 348-417
Range on HMM: 83-154/349.0
KRSGHTQTDYINASFMDG--YKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWP
.  .    ||||| ..    .. .. || || ||  |  ||. ..  ..| ...  .  .| . .|| .|| 
esdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywq
0046846 (Phosphotyrosine protein) phosphatases II 353-575 5.4e-42 138.8 In-house 10-173 (176) alignment 
Range on Protein: 353-575
Range on HMM: 10-173/176.0
TQTDYINASFMDGYKqknaYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIrfgfltvtnlgvenmnhykkttleihnt
   |||||....|..    .| |||||..|. ||. |..|... ..|. |   | || || .|||....  |                            
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

eerqkrqvtHFQFLSWPDYGVPSSaASLIDFLRVVRNQQslavsnmgarSKGqcpePPIVVHCSAGIGRTGTFCSLDiclaqLEEL-GTLNVFQTVSRMR
         ....| |||.|||.. . |...|. .|...          ..|     |..||||||||||||.. ..     | ||   |.|.......|
.........qylhlpwpDhgvpdl.elllellefireal..........keg....gpvlVHCsaGigRtgtlvaay.....llelekglsveealalvr

TQRA-FSIQTPEQYYFCYKAILEFA
 ||  ...||||||.|.|...|.. 
eqRplgavqtpeQyrflyefellll
0043147 (Phosphotyrosine protein) phosphatases II 354-568 4.9e-44 145.4 In-house 4-154 (172) alignment 
Range on Protein: 354-568
Range on HMM: 4-154/172.0
QTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFeeggrrkcgqywplekdsrirfgfltvtnlgvenmnhykkttleiHNTE
 .||||||..|.|   . .| ||||| ||. ||| |..|... .||. |..                                              .. 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.............................................lydp

ERQKRQVTHFQFLSWPDYGVPsSAASLIDFLRVVRNQQ--SLavsnmgarskgqcpEPPIVVHCSAGIGRTGTFCSLDICLaqleelGTLNVFQTVSRMR
|  .|.. ....|.|||.||| ... |..||. ... .  |               . |..||||||.|||||.. ....|        |.....|. .|
ellerlgiqylylpwpDhgvp.llellleflefidellalsp..............ggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvr

TQRAFSIQTPEQYYFCY
..|  ..|.|.||.|.|
ekRpgavqnpsqyrfly
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 354-473 2.3e-11 38.1 In-house 12-126 (130) alignment 
Range on Protein: 354-473
Range on HMM: 12-126/130.0
QTDYINASFMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGgrrkcGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTE
. .||||||.    . . |. || || .|  ||| |. |. | |.|.    ||       .|||  .        ..||    ..... | . |||..  
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdrdefknikasnleiesdl

ERQKRQVTHFQFLSWPDYGV
 . .. .| ||   ||  | 
neshqaltmfqisnwpsdgt
0051429 (Phosphotyrosine protein) phosphatases II 355-576 4.1e-52 172.8 In-house 4-226 (272) alignment 
Range on Protein: 355-576
Range on HMM: 4-226/272.0
TDYINASFMDGYKQ---KNAYIGTQGPLENTYRDFWLMvWEQKVLVIVMTTRFEEGGRRKCGQYWP----------LEKDSRIRFGFLTVTNLGVENMNH
..||||....|| .   ..... ..|||..| .||| . .|... .||. .. || || || .|||           . . .|..|.|.||.| .|....
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YKKTTLEIHNT-EERQKRQVTHFQFLSWPDYGVPSSAasLIDFLRVVRNqqslavsnmgarskgqcpEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT
|  ..|.....    . |.|.|.....|||.|||..|  |...|.....                  . |..||||||..||||.. |...|.....   
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld..................ggpvlvHCsaGkdRTGtvvallllllgvsleti

LN--------VFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAE
..        ....|...| ||. ..||.|||.|.|.|.||...
vddYlltnlyleeaveelraqrpgavqteeqylflyeallellr
0036282 (Phosphotyrosine protein) phosphatases II 355-569 5.7e-48 158.2 In-house 2-164 (174) alignment 
Range on Protein: 355-569
Range on HMM: 2-164/174.0
TDYINASFMDGYKQKNAYIGTQGPLEntyrdFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLekdsrirfgfltvtnlgvenmnhykkttleihnTEE
.||||||..|..   . .| .||||.     || |..|... ..|| .. .| |. || .|||                                  . |
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

RQKRQVTHFQFLSWPDYGVPSSAAsLIDFLRVVRNQQslavsnmgarskGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEeLGTLNVFQTVSRMRTQR
  .| . ....| |||.|||...  |..|.. |.. .             ..|. |..||||||.|||||.. ....| .|.  .. .....| ..|.||
dlerlgiqylylpwpDhgvpdlsi.llefvkfveeal............sedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqr

AFSIQTPEQYYFCYK
  ..|||.||.|.|.
pgmvqtpsQyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 355-572 1.1e-35 117.8 In-house 3-150 (151) alignment 
Range on Protein: 355-572
Range on HMM: 3-150/151.0
TDYINASFMDGYkqknaYIGTQGPLEntyrDFWLMVWEQKVLVIVMTTRFEEGGrrKCGQYWPLEKdsrirfgfltvtnlgvenmnhykkttleihntee
.||||.|...|.     .. ..|||.    ||. ...|... .||. .  || |  .| .|.| .                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg..................................

rqkRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNqqslavsnmgarskgqCPEPPIVVHCSAGIGRTGTFCSLDICLAQleelgtLNVFQTVSRMRTQR
   ..|.|...|.|||.|.| | .....||.....                ... |..||||||.|||||.. |...| .      ........ .| .|
...ievlhipildwpdpglplsfdavleflellld................kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkr

AFSIQTPEQYYFCYKAIL
  ..|...|..|...|.|
pgvvqpnqqflfqlfall
0049260 (Phosphotyrosine protein) phosphatases II 362-569 5.2e-41 135.2 In-house 1-144 (152) alignment 
Range on Protein: 362-569
Range on HMM: 1-144/152.0
FMDGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWplekdsrirfgfltvtnlgvenmnhykkttleihnteerqkrqvt
|.|||......|.||||..||. ||| |..|... .||| |...| |. || ||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

HFQFLSWPDYGVPSSAASLIDFLRVVRNQqslAV---SnmgarskgqcpepPIVVHCSAGIGRTGTFCSLDICLaqleelGTLNVFQTVSRMRTQRAFSI
....| |||.|||...  |...|....     |                  |..||||||.|||||.. ....|        ......|...|..|  ..
qylhlpwpDhgvpdlsqlllflllfiekl...aldkgg.............pvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgav

QTPEQYYFCYK
..|.|..|.|.
pnpgqlrflye
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 362-566 1.2e-18 61.6 In-house 82-279 (302) alignment 
Range on Protein: 362-566
Range on HMM: 82-279/302.0
FMDGYKQKNAYIG-TQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVEN-MNHY------KKTTLEIHNTE
 ||| ..|.        |  .|   .| .. . .| ..|  . | |.. .|| .|.  . . ...||  ||. . |.. ....      |  |.||.|..
pmdGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknek

E--RQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSlavSnmgarskgqcpeppIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMR
   ..|. |  ..| .|||.| |  | . .| |.     .    .              ..||||||.|||||. ..   .    .  . .. . |  .|
kkkkvkktvdilafsawpdhGapkeaytaldilkfcesykk...n..............vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvr

TQRAFSIQTPEQYYF
. |  ..|. .|  .
qcryGavqdeqqliy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 364-571 2.2e-35 116.8 In-house 230-434 (440) alignment 
Range on Protein: 364-571
Range on HMM: 230-434/440.0
DGYKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEggrRKCGQYWPLEKDSrIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQkrQVTHF
.|| .|||.| || ||. |  ||| .| . ..  |.|  ....   . |  |||..  | . || .||   | ||||  |  |||..  || .  ..  |
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrs.vtfgpftvghkgsenmnrvkvrtlelkykeevh..eirqf

QFLSWPDY----GVPSSAASLIDFLRVVRNQQSLAVSNMGARSKGqCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQ
.  .|| .    || |    .   |...   .   .     .|.     |||.||| .||  .| ||..  || ||.. |...||| .  .|  |   . 
evqtwptwiqsdgvqsqeqcmdavlqlmdylrkceiqrsteqsrp.gdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvp

TPEQYYFCYKAI
|  .| .||| .
tltdyllcykll
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 367-569 5.9e-25 82.6 In-house 2-198 (199) alignment 
Range on Protein: 367-569
Range on HMM: 2-198/199.0
KQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHN--TEERQKRQVTHFQ
| .  || || || .|  ||| ||||     |||    .         |||  . .  ..| |.||   .     |  |.| . |  |     |...|.|
kgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyq

FLSWPDYGVPSSAaSLIDFLRVVRNqqslaVSNmgarSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT--LNVFQTVSRMRTQRAFSIQTPE
| || .   |  |  .. |.   |.     ||.       |  . |..|||| | | || | .||| .   ||  |  ...|.   |.|  |   | . .
ftswkekttpnva.lfvgfvvasre.....vsk....kyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslq

QYYFCYK
.| | |.
hynfiyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 367-575 6.2e-22 72.9 In-house 32-221 (255) alignment 
Range on Protein: 367-575
Range on HMM: 32-221/255.0
KQKNAYIGtqgplenTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFL
|.|| |.        |   |. ..  .|  |.|| . |.| |. || .|.||||| . ..  ..||     .    .  ..  . .| .. ..|.|... 
krknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysyk

SWPDYGVPSSAASLIDFLRVVRNQQSlavsnmgarskgqcpeppIVVHCSAGIGRTGTFCSLDICLA----QL--EELGTLNVFQTVSRMRTQRAFSIQT
 |..   |  |  .   |.|||. .|                  .|||||.||||. .|   ..       .|   | . |.  . .  .| .|. .|.|
GWieknaPelareilnilkvvrdsks..................vvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraiht

PEQYYFCYKAILEFA
| |  |.   .|.. 
Plqlafsilmvldlv
subfamily_hpo-7_pd Subfamily hpo-7 367-496 2.9e-17 57.4 In-house 35-160 (263) alignment 
Range on Protein: 367-496
Range on HMM: 35-160/263.0
KQKNAYIGtqgpLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENmnHYKKTTLEIHNTE--ERQKRQVTHFQ
|.|| |.     | .|   |. ..  .|  |.|| . |.| |. || .|.||||| . ..  ..|.   | .     . |||. .|    .. ..|.|..
krknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhys

FLSWPDYGVPSSAASLIDFLRVVRNQQSLAVS
.  |..   |  | . .  |.|.|| .|| | 
ykgWiekndpelareilnilkvarnskslvvh
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 369-569 8.5e-25 82.1 In-house 3-197 (198) alignment 
Range on Protein: 369-569
Range on HMM: 3-197/198.0
KNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIRFGFLTVTNLGVENMNHYKKTTLEIHN--TEERQKRQVTHFQFL
.  || || || .|  ||| ||||     |||    .         |||  . .  ..| |.||   .     |  |.| . |  |     |...|.|| 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

SWPDYGVPSSAaSLIDFLRVVRNqqslaVSNmgarSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGT--LNVFQTVSRMRTQRAFSIQTPEQY
|| .   |  |  .. |.   |.     ||.       |  . |..|||| | | || | .||| .   ||  |  ...|.   |.|  |   | . ..|
swkekttpnva.lfvgfvvasre.....vsk....kyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhy

YFCYK
 | |.
nfiyq
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 411-582 2.9e-09 30.9 In-house 149-309 (332) alignment 
Range on Protein: 411-582
Range on HMM: 149-309/332.0
KCGQYWPlEKDSRIRFGFLTVTNLGVENMNHYKktTLEIHNTEERQKRQVTHFQFLSWPDygvpssAASLIDFLRVVRNQQSLAVSNmGARSKGQCPePP
 | ..|| || |.  |  |..      .  | |  |...  ||..| .|   ..|  | |      |. | ...  .|    |      ..  | |   |
icrkfwp.ekrskkdfpalsiqasddhsethmk..tfnltvtekkqdhqtvlmhfyewad......asklpeymldmrasiklqyir.sskktgvci.gp

IVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEKEGMVS
|.. |..|. .   ....|| .... |   . . .|.| .. ||   ..|   |  . . ...||   |.| 
imlvcatgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpystacemlmkfavttgvvh
0048076 (Phosphotyrosine protein) phosphatases II 414-573 9.5e-28 92.1 In-house 1-141 (145) alignment 
Range on Protein: 414-573
Range on HMM: 1-141/145.0
QYWPLEKDSRIRFGFLTvTNLGVENMNHYKKTT-LEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLavsnmgarskgqcpEPPIV
.||| | . .. .| |. | | .|.. ... || | . ...|  .|.......|.|||.|||.... |..||. ... ..               . |..
pywpseilpglylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealke..............ggpvl

VHCSAGIGRTGTFCSLDICLAqleeLGtLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
||||||.|||||.. ....|     || ....... ..|.|| .....|.|..|.|...||
VHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpgqlrflyefele
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 439-574 7.1e-18 59.4 In-house 199-343 (350) alignment 
Range on Protein: 439-574
Range on HMM: 199-343/350.0
MNHYKKTTLEIHNTEERQkrqVTHFQFLSWPDYGVPSSAASLIDFLRvvrNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEEL
 .... | ...  ..      | ..|.  |.| ..     |..  |     .. |  ...      .   .||.||||||.|||||...||  | ..| |
kdnnsltaitlaasdPyv...vyqlqvknWkDlslllnPesilqale...vkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeil

GTL---------------NVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEF
 .|                ....| ..| ||   .|. .|. |.|.|.| .
enltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfy
0048179 (Phosphotyrosine protein) phosphatases II 450-569 5e-25 83.3 In-house 39-139 (144) alignment 
Range on Protein: 450-569
Range on HMM: 39-139/144.0
HNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQqslavsnmgarskgQCPEPPIVVHCSAGIGRTGTFCSLDICLaqleELGtLNVFQTVSR
.   |  .|.......|.|||.|||.... |..||. ...               . .. |..||||||.|||||.. .....    .|| |...... .
eyepefleregiqylhlpwpDhgvpdllellleflefieea..............leeggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealal

MRTQRAFSIQTPEQYYFCYK
.|..| .....|.|..|...
vrsrrpgavpnpgqlrfLle
0038934 (Phosphotyrosine protein) phosphatases II 450-568 1.1e-08 30.5 In-house 70-170 (194) alignment 
Range on Protein: 450-568
Range on HMM: 70-170/194.0
HNTEERQKRQVtHFQFLSWPDYGVPSSAASLIDFLRVVRNQQslavsnmgarskGQCPEPPIVVHCSAGIGRTGTfcsldICLAQLEELGTLNVFQTVSR
 ..|| .|. . ..  | .||.|.. | . | .||..|                 ..|.  ..||| ||.|||||     .. | | .   ... . . .
Ydpeefekagi.eylklpfpddgtvPsleillrfldlvdefl............nedpggvvaVHCkaGlgRtGt.....lvaaYLiyrlgmsaeeAial

MRTQRAFSIQTPEQYYFCY
.|  |  .|......   .
frekRpgaipnqdyleall
subfamily_PTPDC1_pd Subfamily PTPDC1 452-568 3.3e-08 28.2 In-house 75-169 (182) alignment 
Range on Protein: 452-568
Range on HMM: 75-169/182.0
TEERQKRQVTHFQFlSWPDYGVPSSaASLIDFLRVVRNqqslAVSNmGaRskgqcpeppIVVHCSAGIGRTGTFCSLDICLAQleelgTLNVFQTVSRMR
.|. .........| .|.||||.|   ...|  .||      |... | .         . ||| || ||||   .  .  |.      |.  .... .|
lealmeqgiyvynf.gwkDygvasl.eriLdivkvvaf....alqe.g.k.........vavhChaGlGrtGvliacylvyak.....rltaekaiklvr

TQRAFSIQTPEQYYFCY
 .|. |||| ||  .. 
skrpksiqtreqvelvk
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 455-575 5.3e-12 39.7 In-house 215-344 (349) alignment 
Range on Protein: 455-575
Range on HMM: 215-344/349.0
RQKRQVTHFQFLSWPDYGVPSSAASLIDFLRvvrNQQSLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQL------------EELGTLN
..  ..  .|.  |.| ..     |..  |     .. |  ...      .   ....|||||| ||||... ||. |. |            . |    
ekPyellqlqvknwldlslllnPisilqale...vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDl

VFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFA
.. .|  .| ||   .|   |. ..|.|.|.. 
isiivnelrkqrismvqnlaqfiaiyealLkyf
PTPc_DSPc_SM00012 459-573 7.2e-36 117.9 In-house 1-105 (105) alignment 
Range on Protein: 459-573
Range on HMM: 1-105/105.0
QVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQSLAVSnmgarskgqcpEPPIVVHCSAGIGRTGTFCSLDICLAQLEEL-GTLNVFQTVSRMRTQRAFS
.|.|.....||| |||... |....|| |..... . |           ..|.|||||||.||||||. |||.| |||.  .....||.|...|.||. .
tvkhyhytgwpdhgvPeesdsilellravkknknkses...........skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgm

IQTPEQYYFCYKAILE
.|| ||| |.|.|.||
vqteeqylflyralle
subfamily_CG42327_pd Subfamily CG42327 496-577 7.5e-19 62.5 In-house 235-317 (319) alignment 
Range on Protein: 496-577
Range on HMM: 235-317/319.0
SNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEEL-GTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILEFAEK
.|. .||  .    |.||||| |.||||.  . || . .|||   .... |.|| .| .|| ...| ||| | || . |.|.|
gnissrsgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseyakk
PTEN_1 509-566 5.7e-06 21.3 In-house 131-184 (196) alignment 
Range on Protein: 509-566
Range on HMM: 131-184/196.0
PPIVVHCSAGIGRTGTfcsldICLAQLEELGTLNVFQTVSRMRTQR-AFSIQTPEQYYF
  ..||| ||.||.||     .. | | ..| |.. ......| .| . ....|.|  .
nvVlVHCkaGlgRsGt.....vvaayLmykgkltadeAlelvrekRppgapnspsqerl
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 511-573 1.3e-09 32.3 In-house 1-63 (69) alignment 
Range on Protein: 511-573
Range on HMM: 1-63/69.0
IVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
.|||||.| |||||| .. . .|..     ...|  |  ||  |   .    .| | . |. |
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 512-573 1.8e-09 31.8 In-house 1-62 (69) alignment 
Range on Protein: 512-573
Range on HMM: 1-62/69.0
VVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE
|||||.| |||||| .. . .|..     ...|  |  ||  |   .   ..| | . |. |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve