Gene PTPRA in Homo sapiens

Synonym: HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, R-PTP-alpha, RPTPA, RP4-534B8.1, PTPRA

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRA
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP088_AA protein Get Run
HsapP088_AA_223-503 phosphatase_domain Get Run
HsapP088_AA_515-793 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
DUF3357 Domain of unknown function (DUF3357) 130-200 6.9e-06 12.4 Pfam-A 10-73 (107) alignment
Range on Protein: 130-200
Range on HMM: 10-73/107.0
TTPETFPPSGNSdS-KDRRdetPIIAVMVALSSLLVIVFIIIVLymlrFKKYKQAGSHSNSFRLSNGRTEDV
  ||. ...... | . ||   |.  ... |||||........|     .. .|. ..... . |. .....
pLpegdesasep.sarrrr...plkvllavlsslllllllvall....vvskgqspdgdeaasssseespes

0050432 (Phosphotyrosine protein) phosphatases II 207-507 7.5e-107 352.4 In-house 12-304 (308) alignment
Range on Protein: 207-507
Range on HMM: 12-304/308.0
LLARSPSTNRKYPPLPVDKLEEEINRrmADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLtpveGvPDSDYINASFINGY--
|| |..|.. .. .|.|..| . ...  |.|..|..|||..|.....  ....|...|||.||||..|||||||||.|    . ..|||||||...||  
llfrdtsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyss

QEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ---GCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGdmtnRKPQRLIT
  ..||||.|||...||.|||||.||||. .|||.|.| |..  |||||||.    |...||...| . ...|| |||||..... .|     .. | .|
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg....dgesrtvt

QFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQyaGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
.||.|.|||.|||  |  .|.||..|. ..|.  | |||||||||||||||...| .|.....|..|||.. | ..| ||..|||| .||.|.|.||||.
hfhytnWpdhgvPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralley

YLYGDT
...  |
lklklt

subfamily_PTPRA_pd Subfamily PTPRA 209-537 4.7e-203 668.2 In-house 2-330 (330) alignment
Range on Protein: 209-537
Range on HMM: 2-330/330.0
ARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKN
|||.|.|.||.||||.||||||..|.||||||||||||||||.|||||.|.|||||||||||.|||||||.|||.|...|||..|||||||||.||.||.
arsrsgnkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekd

KFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSW
|||||||||||||.|||||||||..|||||.|.||||||.||||||||.|..|||||||.|||.|||||||||||..||..|.|..|..||..|||||||
kfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftsw

PDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTE
||.||||.||||||.|||||..|.|.||.|||||||||||||||.|.||.|.....||||||..||.|.|.||.||||||.||.|||..|||.|||||||
PdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdte

LEVTSLETHLQKIYNKIPGTSNNGLEEEF
|.|.|||.||||.||||.||...||||||
ldvsslekhlqklynkitgtdkigleeef

0039614 (Phosphotyrosine protein) phosphatases II 214-507 9.2e-100 329.2 In-house 7-294 (297) alignment
Range on Protein: 214-507
Range on HMM: 7-294/297.0
TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQatCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGV-PDSDYINASFINGYQE-KNKFI
.  ...| |.. |.  . .. |... |...||  |. ...   .. | ..|||.||||..|||||||||.|.|..|| .||||||||...||   ..|||
allesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfI

AAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKEcKCAQYWPDQGCwTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmtnRKPQRLITQFHFTSWPDF
|.||| .|||.|||||.|||.. .|||.|.|.|..  |||||||. |  |||...| . .|..| .||||.....        .. | .|.|..|.|||.
atqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn......ngesrtvthfqytgwpdh

GVPFTPIGMLKFLKKVKACNPQ--YAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDT
||| ..  .|.||..|. .. .    | ..|||||||||||||.... ||.....|..|||.  |...| ||...|||. ||.|.|.||||......|
gvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt

0045450 (Phosphotyrosine protein) phosphatases II 218-502 3.9e-97 320.9 In-house 6-304 (307) alignment
Range on Protein: 218-502
Range on HMM: 6-304/307.0
YPPLPVDKLEEEINRRMADDNKLFREEFNALPACPI--QATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGV-PDSDYINASFI--------NGYQE
...... ||. .......|.. ....||. |. . .    ....|...|||.||||..||||||.||.|....|  .||||||||..        .||  
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

KNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCW-TYGNIRVSVEDVTVLVDYTVRKFCIQQVgdmTNRKPQRLITQFHF
|.||||.|||..|||.|||||.|||.. .|||.|.|.|..  |||||||| | . ||||..| . ....| .||||.....        .. | .|.||.
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl...dgtgesrtvthfhy

TSWPDFGVPFTPIGMLKFLKKVKACNPQ--YAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERK---VDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
|.|||.||| ..  .|.|...|.... .    | ..|||||||||||||.... ||.....| .   ||..  |...|.||...||.  ||.|.|.||||
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

HY
..
ll

subfamily_PTPRD_pd Subfamily PTPRD 219-545 4e-136 449.9 In-house 3-325 (564) alignment
Range on Protein: 219-545
Range on HMM: 3-325/564.0
PPLPVDKLEEEINRRMADDNKLFREEFNALPACpIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKE
.|.||..|.| ...  |...  | ||.. .     | |.|||.|..||.|||| ||..|||||| |..|||...|||||||||.||......||.|||..
kpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGdmtnRKPQRLITQFHFTSWPDFGVPFTPI
||..|||||.||||..||||.|.|.|... ||..|||..|  |||.. |..|. . | ||..|.| ...      .. .| ..||||||||| ||| .. 
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk....ssesreVrqFhFtsWPdhgvpesat

GMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL
..|....||.|.|.. || |||||||||||||||.||||||. ...|..||.|..|...|.||  ||||  ||.||..|.||    |.||.|. .|..||
slLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhl

QKIYNKIPGTSNNGLEEEFKKLT-SIKI
||. .. ..|.  ||| ||..|. . .|
qkLaeveedtemtgleleFqrLatakei

0051299 (Phosphotyrosine protein) phosphatases II 219-502 3.6e-111 366.5 In-house 3-286 (288) alignment
Range on Protein: 219-502
Range on HMM: 3-286/288.0
PPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKE
 ...|..|.. .....|.......|||..|... .. |. ||...||.|||||..|||||||||.|....||..|||||||.|.||. |.||||.|||..
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

ETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPI
.||.|||||.||||. .|||.|.| |..  |||||||..|..|||.|.|   ...|| |||||..... .. ..  .  | .|.||.|.|||.||| .| 
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

GMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY
 .|.||..|. ....  | .||||||||||||||...| .|.....|..|||...| |.| ||..|||| .||.|.|.||||..
llldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 219-524 5.9e-103 339.5 In-house 14-313 (319) alignment
Range on Protein: 219-524
Range on HMM: 14-313/319.0
PPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQAT-CEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPK
|..|. ...  ... . || . .. ||....  ... .  . |  ..||.|||..|||..|...| | ...|.  ||||||||..||| |.|.||||||.
pdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPl

EETVNDFWRMIWEQNTATIVMVTnlkerkECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNrkpQRLITQFHFTSWPDFGVPFTP
..|..||||||||.|..|||..|      . ||.|||| ..  ....  |.|. |.   .|.||.. . . | ...   .| ||||||  ||| |||  |
dntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekd...irkitqfhflGwpdvGvpdyp

IGMLKFLKKVKACN--PQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLE
. .....|||.  .   .    |||||||||||||...|.|..||.|. |..|||| ||  .| || ..||  .|| ||| ||||..|.| ... .  . 
sdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfp

THLQKIYNK
..|..  ||
ayleelsnk

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 219-535 3.8e-92 303.6 In-house 4-312 (315) alignment
Range on Protein: 219-535
Range on HMM: 4-312/315.0
PPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQAtCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKE
 |.|.|.|   . .. |  .. |.......|   ..   . | | |||.||||.||..||.|||.|  .|  |.|||.||.||.||. |...||||||. 
qpipldqlityvaqkkastkngfkqdyesipggqlhp.ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQgCWTYGNIRVSVEDVTVLVDYTVRKFciqqvgDMTNRKPQRLITQFHFTSWPDFGVPFTPI
..|.||||...|.. ..|||.||| |... |. .||||.   .||.| |.  .  |  .|||| .       .. ..  | . |.|.||||| |||   |
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl......svvfgdnirevvqlhytswpdmgvpkyti

GMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL
 .... ..||  . . .|||||||||||||||||. .||.|| ...|. .||| |. ..|..| .|||.  || |||.|||| .. ||| .       . 
plmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqry

QKIYNKIPGTSNNGLEE
. .    | | .  |.|
dsllapspdtgstllqe

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 220-538 9.3e-113 371.5 In-house 4-319 (319) alignment
Range on Protein: 220-538
Range on HMM: 4-319/319.0
PLPVDKLEEEINRRMADDNKLFREEFNALPAcPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEE
...|..|.|....  .  ..|...||. |   . . | . |||||||.|||| |||.||..|| |....||..|||||||||.||||..||||.|.|.|.
eievqeLkerlkalastgetllekefkllke.avndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen

TVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRkpqRLITQFHFTSWPDFGVPFTPIG
|..|||||.||... ..||.|.|.|. . |. .|||..  ..||.. | .|.   | || .||.....  .  .    | ...|..|.||| .|| .  .
tiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevet...RevkhfqyteWpdhdvPekats

MLKFLKKVKACNPQ-YAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL
.|..||...    .  .| |||||||||||||||.|.||||. .. |  .||. .|||.|.||  |||.  || |||.||||    ||||.||  |.. |
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrl

QKIYNKIPGTSNNGLEEEFK
... .|...| . ||| ||.
kqlaekvadtgetglerefq

subfamily_Ptp69D_pd Subfamily Ptp69D 220-521 3.3e-101 333.5 In-house 3-305 (307) alignment
Range on Protein: 220-521
Range on HMM: 3-305/307.0
PLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEE
....|.|||... |  | . .. .|.. |.|  |. ..... |.||. |||| .| ..|. || |....|  ||||||||||.||.||.||||||.| |.
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMT-NRKPQRLITQFHFTSWPDFGVPFTPI
|..||||||.||.  .|||..||.| .. |||.|||..    ||.| | . .     ||. |.. . .... . . . .| ..|.|.|.|.|. || .. 
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevar

GMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL
|.||....|.  . .  . |||||||||||.|.|| .| .|. ...| |||.. .|  .| ||  .||   ||||.|.|||..  ||||. .| .|| ..
gllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledai

QKI
...
erl

subfamily_PTPRB_pd Subfamily PTPRB 220-501 7.8e-101 332.0 In-house 6-284 (293) alignment
Range on Protein: 220-501
Range on HMM: 6-284/293.0
PLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEE
|. ..|.|| ...  ||..  | ||.. | |   . ...||....|..|||| ||||||||||.|..... ..||||||..|.||. ...|||.|||  |
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ-GCWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmtnRKPQRLITQFHFTSWPDFGVPFTPI
||.|||||.||... .|||.|.| |.   || .|||..    .||.|.|..   ..| |...|.. |..      .| .| ..|.|||||||.||| .. 
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek......ekeerkvrqyhftsWpdhgvPektk

GMLKFLKKVKACN--PQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
 .|.|...|.      . .. |||||||||||||||. .| .|. ...|  ||..|.|...| .|...|||  ||.||.|..|. 
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 220-539 7.1e-89 292.7 In-house 2-314 (315) alignment
Range on Protein: 220-539
Range on HMM: 2-314/315.0
PLPVDKLEEEINRRMadDNKLFREEFNALPACPIQATCeAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEE
|.|| ..   .|.       || |||. ||  .|  .  .| ...| .|||| ||||.|..|| |  ..  |||||||||.|..... . .||.|||.. 
pipvaqfpafvnknr..htalfseefhdlpdPdiyrqr.varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlka

TVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD--QGCWTYGNIRVSVEDVTVLVDYTVRKFcIqqvgdMTNRKPQRLITQFHFTSWPDFGVPFTP
.|.|||||.......||||||...|    ||.|||||       .|.|.|.. ..    | ..||. .     . . . .| .|||.|| ||| ||.   
svddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.v.....trkseesrtvtqfqftewPdkGvdkqt

IGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETH
  .||..|.||| | ..  ...||||||||||| .. || ... .. .| |||. ||  .||.| ..|||. .| |||.|.||. |. .| . |  .  |
ssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdh

LQKIYNKIPGTSNNGLEEEFKK
|| ..    |.  . . .||..
lqdlhtsvdgsgrskmtkefet

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 220-512 4.9e-81 267.1 In-house 9-294 (297) alignment
Range on Protein: 220-512
Range on HMM: 9-294/297.0
PLPVDKLEEEINRRMadDNKLFREEFNALPACPIQATCEAaSKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEknKFIAAQGPKEE
|.|. ..   ... .  . ..|.|||. ||.  ||..  |  |  | ||.|| |||||| |||.|  |.  |||||.||||..|...  ..|. | |...
piplsdfatlvqknr..htdvfseeflclpeaniqpqtva.ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

TVNDFWRMIWEQNTATIVMVTNLKERKEcKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmTNRKPQRLITQFHFTSWPDFGVPF--TP
||.|||.|.......||||.....||.. |||.||.|.|  |.|.. | .. |.    .  |.. ...     . | .|.. |..|..|||  |.   . 
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtk....gkakarrvvkqyqfveWPdkaverkdsa

IGMLKFLKKVKACNPQYAG-AIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVT
  .||... |.    | |   ..|||.||||||| .. || ..  .. | .||..|.|...| .| ..|||. || |.|.|.||  |  ||.....
ssllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 220-540 2e-74 245.3 In-house 3-274 (392) alignment
Range on Protein: 220-540
Range on HMM: 3-274/392.0
PLPVDKLEEEINRRmaDDNKLFREEFNALPACPIQATcEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEE
|.|| ..   ...     . || |||  ||  .|  .  .| || |..|||| |||||| .||.|  .. .|||||.|||.|.... .. .||.|||.  
pipvaqfpafvekn..rhsalffeefhdlpgpdiypq.tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaa

TVNDFWRMIWEQNTATIVMVTNLKERKeckcaqywpdqgcwtygnirvsvedvtvlvdytvrkfciqqvgdmtNRKPQRLITQFHFTSWPDFGVPFTPIG
...|||||....|..||.|||.|||                                                . . .| ..||||| ||| .||     
slddfwrmvfqenvttiamvtklkegd..............................................kgddartvaqfhftewPdkdvpkhtss

MLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQ
.|||.|.|||   ||.  ...||||||||||  . ||...   .. | |||. ||. || .|  ||||. || ||| |.||  |. .| . |  .  |||
llkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlq

KIYNKIPGTSNNGLEEEFKKL
..     |  .     ||..|
dlstssdGdvrskqlkefrsl

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 221-540 8.5e-113 371.6 In-house 2-318 (318) alignment
Range on Protein: 221-540
Range on HMM: 2-318/318.0
LPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEET
..|..||. ..| ... . |. ||...|  .. ..|   . .. || ||||.|||.|||.||.|...||...||||||..|.||..|...||||.|  ||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

VNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmTNRKPQRLITQFHFTSWPDFGVPFTPIGM
..|||||.||||.|.|||.|...||   |...|||..|  .||...| ... . | ||..|.| ...    |. . .| . |.|.||||| |||  . ..
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr....teeeesrqvrqyhytsWpdegvpesgasl

LKFLKKVKACN-PQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQ
|.....|.. . .. ||.|||||||||||||.|...|..|. .. |  |||...|...| ||  ||||. ||.|||..|||    |||| . . | ....
ldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrir

KIYNKIPGTSNNGLEEEFKKL
.. .. | . .  .. ||..|
elreqdpesgttemdaefqrl

0043336 (Phosphotyrosine protein) phosphatases II 221-501 7.4e-100 329.2 In-house 2-276 (278) alignment
Range on Protein: 221-501
Range on HMM: 2-276/278.0
LPVDKLEEEINRRMADDNKLFREEFNALPACPIqATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEET
..| .|.. ..........|...||  |. ...  |.. | ..|||.||||..|||||||||.|....|..||||||||...||. ..||||.||| .||
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

VNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPdQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmTNRKPQRLITQFHFTSWPDFGVPFTPIGM
|.|||||.||... ||||.|.|.|.. .||||||| .| .|||...| . ....| |||||....      .  .. | .|..|...|||.||| ..  .
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn....lgdgesrtvthyhylgwpdhgvpeslsll

LKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
|.|||.|. ...   |...|||||||||||||.... .|.....|..||..  |...| ||...|||..||.|.|.||||.
ldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 221-503 2.6e-72 238.2 In-house 2-279 (287) alignment
Range on Protein: 221-503
Range on HMM: 2-279/287.0
LPVDKLEEEINRRMADDNKLFREEFNALPA---CPIQATCEAASkeENKEKNRYVNILPYDHSRVHLTpvegVPDSDYINASFINGYQEKNKFIAAQGPK
.||.|. | ...  |  |. |.. |  |      . . | . ||  .||.|||. .||..|  || |       . |||||.||.||.||..||.|..| 
ipvekfgefvakghakgnegfknqftvleqvtqredevthnias..qnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPm

EETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGdmtNRKPQRLITQFHFTSWPDFG-VPFT
 .|. .||..|...|  .|||....|| .| .| ||||.. . ..|. .... . .|  .|..||. ... .   . .... ..|...|.|.. | |.  
fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknkn...kagdkqqvkqyqitnWdstgkvtep

PIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYL
   .| . ...|.   .  ..||||||..|||...|. ..  ..  .||  .||.  . . | |. ..|||  || ||....||.  
qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld

subfamily_PTPRG_pd Subfamily PTPRG 222-516 1.4e-107 355.3 In-house 2-301 (563) alignment
Range on Protein: 222-516
Range on HMM: 2-301/563.0
PVDKLEEEINRRMADDNKLFREEFNALPACPIQA--TCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDS-DYINASFINGYQEKNKFIAAQGPKE
||..... .    ||... | |||.||  . |.   ..|...|.|||.||||.||..||.|||.|.|. |. .. |||||..|.||| ...|||.||| .
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

ETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQ--VGDMTNRKPQRLITQFHFTSWPDFGVPFT
.|..||||||||||.|.|||.|||.||.  || .||| ..  |||...|  ..  ||. ||||.. |..  . .  ... ..|..|.|.|.||| |||  
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

PIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLET
..  |.| || .| |.. || ||||||||||||||..|.|..|  ...| .|.|.||. .|||||  .|||  ||.|...||||  . ..|||  . .| 
slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee





subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 222-521 1.9e-89 294.8 In-house 5-302 (305) alignment
Range on Protein: 222-521
Range on HMM: 5-302/305.0
PVDKLEEEINRRMADDNKLFREEFNALPACpiQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETV
 .|.|.. |.   ....| . .....|.    . ...  .||.||.|||...| ..|..|..||. | ..||||||||...||..|.|.|.|||| ..||
alddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

NDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCW--TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDmtnRKPQRLITQFHFTSWPDFGVPFTPIG
.||||.|.|  . ||||.|.|.| .. || ||||..      .|.. | ... .   ||. ||..| .  .    | .| ..|...|.||| ||| ..  
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede...dkesrtvlqyqltdWPdhGvpqfats

MLKFLKKVKACNPQYAG-AIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL
.|...|.|.    .  | ...|||||||||||.|...| .|. ...|  |||.. . ..| .| .||||  ||||...|| |    |||.. .  |. ..
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarv

QKI
.|.
nkl

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 222-501 1.9e-76 251.7 In-house 3-282 (290) alignment
Range on Protein: 222-501
Range on HMM: 3-282/290.0
PVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPD--SDYINASFINGYQEKNKFIAAQGPKEE
||||. | .    |  |. ||..|..| .   . | . .  ..||..||. ||..||  |. | |. | .|   .||||..|.||.||...||.||| ..
pvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn

TVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVgdMTNrKPQRLITQFHFTSWPDFG-VPFTPI
|. |||..||..... |||.|| .| .. || |||||..  .||.... . . ..| .|. ||. ...    .. .... .||...|.|.. | |. .  
tlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknk..nsa.gakqsvtqyqitnwdstgkvtnpqt

GMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
 .| . . .|    .  ..||||||..|||...|....  .. ..||  .||.  . . | |. ..|||  || .|.| .|. 
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty

subfamily_PTPRK_pd Subfamily PTPRK 223-538 1e-98 325.1 In-house 6-313 (314) alignment
Range on Protein: 223-538
Range on HMM: 6-313/314.0
VDKLEEEINRRMADDNKLFREEFNALPACpiqatCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVN
|. | ..|.   . ..  |.||...|.        .|| |.||.||||. .||.||.||| |....| |.||||||..|..|.  ..||..|||..|||.
vadllqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvk

DFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWtYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMtnRKPQRLITQFHFTSWPDFGVPFTPIGMLK
||||.....|.|.|||.|.|.|    || .|||...   ||.|.| . ....| .. || | ....      . .|.. ||.|..|||..||    |.||
dfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklarg..qeeirevrqfqflgWpdhdvPvsatgllk

FLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIY
....||. ... || |||||||| ||||||..|| .|||...|. |||.  |  .|...  ||.|  ||.|||...||  | |.| . |. ...   .. 
lvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesi

NKIPGTSNNGLEEEFK
.  | |    |.|||.
rldpqtnssqlkeefq

subfamily_PTPN14_pd Subfamily PTPN14 223-500 7.5e-64 210.6 In-house 9-294 (300) alignment
Range on Protein: 223-500
Range on HMM: 9-294/300.0
VDKLEEEINRRMAdDNKLFReEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVpDSDYINASFINGY--QEKNKFIAAQGPKEET
 ||. . .....  . |.|  |.. .|    .|....|. .||.||||. ..|||...||.|.| .   ...||||| |.     .. ..|.|||| | |
kdkrakilekkle.egkvft.eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPlelt

VNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ----GCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVgdmtNRKPQRLITQFHFTSWPDFGVPFT
|.|||.|.|||... |||.|. .|    |. .|.|..       ..|. .|. . ..    .. ... .. .      | .| .  . .| ||| |||  
vqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl....pskeertvwhlqytDWpdhgvPeD

PIGMLKFLKKVKACNPQYA---------GAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
. |.|..|..|..   .             ..|||||||||||  .. | ..  .......|.   ..|.| ||  .|||  || |.|..|..
vkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 224-538 1.2e-83 275.9 In-house 8-324 (325) alignment
Range on Protein: 224-538
Range on HMM: 8-324/325.0
DKLEEEINRRMADDNKLFREEFNALPACPIQATcEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVND
 .| | .... |.|.  |  ||. ||.   .|  ..| | |||.|||. |....|.||| |   .  |.|||||||... ...|. |.||| |. .|.||
vnlvehvekkkaqdqdgfahefgllpsddgiak.kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatind

FWRMI--WEqntATIVMVTNLKERKECKCAQYWPDQ--GCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTnrkpQRLITQFHFTSWPDFGVPFTPIG
.||..  |.   ...|.|.|  . .. .||.|||..     |.| ..|..  .  . ||  |.. ..|| .       | . ||.. ||.|.||.  |  
lWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGe....trsvkqfqlqswddmGvqkrpat

MLKFLKKVKAC------NPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTS
.. .|. |||       | . .. |.|||||||||||.|. . ..|. . .| .||..||| ..|..| .||.|  ||..||.|| | |. |.|.. |.|
lisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvss

LETHLQKIYNKIPGTSNNGLEEEFK
.|..|  . .. | | .  .|.||.
feaklsslqernpltqklniekefe

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 224-516 2.4e-77 255.3 In-house 5-293 (439) alignment
Range on Protein: 224-516
Range on HMM: 5-293/439.0
DKLEEEINRRMADDNKLFREEFNALPACPIQATCEA--ASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETV
|...| ...   .....|.|.|. . .   . .|.|  |..| .. |||| .. ..||.|| |  . ||| | |||| .|.|| ... .||.||||.||.
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

NDFWRMIWEQNTATIVMVTNLKERKEckcaqYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRkpQRLITQFHFTSWPDFGVPFTPIGML
.||||...|..|.||||.||| |        ||| ..   ||.| | |.    | .|..| | . .  | |..  .| . |||...|||  ||     .|
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttek..ertvlqfhyiawpdknvpaqashvl

KFLKKVKACNP-QYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLET
.||. ....|  .  | .||||||||||||| . .|  |. ...| |||. | |. .| || ||||.  ||||||.|.||   |||. . .  .. 
dflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk

0040438 (Phosphotyrosine protein) phosphatases II 226-541 1.1e-108 358.6 In-house 5-315 (317) alignment
Range on Protein: 226-541
Range on HMM: 5-315/317.0
LEEEINRRMADDNKLFREEFNALPACPIQaTCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFW
|.. ...... |.....|||. |. ...  |.. |...|||.||||..|||||||||.|.|..|..||||||||...|...|.||||.|||...||.|||
lllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLK
||.|||.. .|||.|.|.|..  |||||||... .|||...| . ....| ..|.|.....      . ...| .|.||.|.|||.||| .|  .|.||.
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl....gdsesrtvthfhytgWpdhgvppspdllldfle

KVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKI
.|......  | ..|||||||||||||.... ||.....|..|||.  | ..|.||...||| .||.|.|.||||......|  ....| ..|.|.....
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllipl

PGTSNNGLEEEFKKLT
....  . |.|.| |.
alddvklkekelklll

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 226-500 6.4e-84 276.4 In-house 2-274 (281) alignment
Range on Protein: 226-500
Range on HMM: 2-274/281.0
LEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFW
|....... ..||. | ||...| |  .. | .|. ..||..||||.||  ||..||..|| |   ..|||||.|..||......||.|||  .....||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMIWEQNTATIVMVTNLKERKECKCAQYWPDQG-CWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFL
.|.|||.  .|||||.  |    || .||||.    .||...|. .  .    |  ||| ...     .  ..| ..|...|.||| ||| |.  .|.| 
qmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkler.....esgetreveqlaytaWPdhGvPattkellefr

KKV-KACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTE-RKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
|.| |. ...   ..|.|||||||||||.. .| ... ...| ...||   |  .| .|  |||| .|| |.|.|.|.
kevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld

subfamily_PTPN23_pd Subfamily PTPN23 226-501 2.1e-64 212.1 In-house 2-279 (288) alignment
Range on Protein: 226-501
Range on HMM: 2-279/288.0
LEEEINRRMADDNKLFREEFNALPACPIQATC--EAASKEENKEKNRYVNILPYDHSRVHLTpvegVPDSDYINASFINGYQEK-NKFIAAQGPKEETVN
|.||..|.| |..  . ..|. |     . .     |  . . ||||. .||||||.||.|         |||||||...      .|||.|.|...|.|
lveelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstln

DFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQG--CWTYGNIRVSVEDVTVLVDYTVRKFCIQqvgdMTNRKPQRLITQFHFTSWPDFGVPFTPIGM
|||.|..|| . .|||... .|... |...||| .     ..|...|....|. .  .  |.. ..    . . .  . ..  ..||||..||| .|  .
DFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkle....tldadavksvshlqltsWpelGvPasPetl

LKFLKKVKAC----NPQYAGAIVVHCSAGVGRTGTFVVIDAMLD-MMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
|.||..|...    . .    .||||||||||||.| .. | .  . . .  .|.   |||.|.||  |||.  |. | |.| ||.
lqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 227-306 9.8e-09 29.2 In-house 3-79 (244) alignment
Range on Protein: 227-306
Range on HMM: 3-79/244.0
EEEINRrmADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEgVPDSDYINASFINGYQE
| |..|   .|... .||| .|     .     |    |  ||||.||||.|..|| |.  .    ||||||..|.| |.
eyevsr..lqdeevakeefvglsdhtreflqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgsqn

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 228-500 2e-95 314.1 In-house 10-277 (288) alignment
Range on Protein: 228-500
Range on HMM: 10-277/288.0
EEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRM
. ...  |.... | ||.|.|.|   . . .|... .|..|||| ||||||. ||.|. .| ....||||||.|.|...|.|.||.|||  .||||||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

IWEQNTATIVMVTNLKERKECKCAQYWPDQGC-WTYGNIRVSVEDVTVLVDYTVRKFCIQqvgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKK
..|..| ||||.|.| |. . || .||||..    ||.. | . ..  | |...||. ..       .| .. |||.....||| |||     .|..|..
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle......kkkteleitqyqylaWpdhgvPeskapllellrq

VKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
||  |.. .| |.|||||||||||||...||..|....| ..|| |.|...| || ..|||  ||.|||..||.
vkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls

subfamily_PTPN6_pd Subfamily PTPN6 229-503 1e-85 282.5 In-house 15-297 (306) alignment
Range on Protein: 229-503
Range on HMM: 15-297/306.0
EINRRMAD-DNKLFREEFNALP--ACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTpVEGVPDSDYINASFINGYQ--EKNKFIAAQGPKEETVND
|...   . ... | |||..|   ..  . . . ..| |||||||| ||||.||.|| |.  ..||.||||||..|.. .  .....||.||  |.||.|
elekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsd

FWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCW-TYGNIRVSVEDVTVLVDYTVRKFCIQQVgdmTNRKPQRLITQFHFTSWPDFGVPFTPIGMLK
||||.|..|.  |||.|.  || . |||.||||.    .||.|.|.  . . | ||..|.. ....   .. | .| . |.||.|||| |||  |  .|.
FWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk...kkkkeerevfqyhfksWPdhgvpkdpgavLd

FLKKVKACNPQYA----GAIVVHCSAGVGRTGTFVVIDAMLDMMHT---ERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALlEHYL
||..|.. . . .    |.||||||||.||||||.|||..|.....   . ..|.. .|  .|.|| ..|||. || |.|.|. ..|.
fledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai.kkyi

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 235-514 4.5e-68 224.2 In-house 5-278 (283) alignment
Range on Protein: 235-514
Range on HMM: 5-278/283.0
ADDNKLFREEFNALPACPIQATCEAAskEENKEKNRYVNILPYDHSRVHLTPVEGvpdsDYINASFIN---GYQEKNKFIAAQGPKEETVNDFWRMIWEQ
...|||||| .. |   . .|....|  .|||.|||. .|.|.|  ||.| .       |||||.||     |....|.|.||.| ..|| |||.|....
vnnnklfrevlkrlsvpdldadiasa..denkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfde

NTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVgdmTNRKPQRLITQFHFTSWPDFGvPFTPIGML-KFLKKVKAC
. ..|||.|.|.| .. ||.|||| .|   ||.  |.... |    ...... ...    .  | . |.. . .  | ..| . ..|  | || | .   
kitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn...ssakstlllahyqvidWleyg.eqaiinslvkfnkvislq

NPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSL
. .  | ||||||.|.|||..|. . | .. . ||  |||.  |  .| ||  .|||  || ..... ||. | |||..    |
teskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdl

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 235-503 1e-22 75.1 In-house 18-280 (303) alignment
Range on Protein: 235-503
Range on HMM: 18-280/303.0
ADDNKLFREEFNALPACpIQATCEAASKEENKEKNRYVNILPYDHSRVHLTpvegvpDSDYINASFINGyQEKNKFIAAQGPKEETVNDFWRMIWEQNTA
 .| ..  .||. . .  .  .       .| .|||.|...  |||.|.|.      || || ||...  . ..| | .| |   |  |||.|| ||.  
dedaniavnefekvvsy.lppsvsknqfvknmdknrfvdvicldhskvkls......dssyihasylel.dsskkailtqlplshtaadfwqmiieqkvk

TIVMVTNLKERKECKCAQYWPD-QGCWTYGNIRVSVEDVTvlvDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFT-PIGMLKFLKKVKACNP
 ....    | ..      .|  |    . .  . | .        . .    .|  ..| . . ..   |. .||   .|      ..| . ....   
cvlllltdseydklggdsvfprnqdflkfeersirvgefk...rvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlr

QYAGA--IVVHCSAGVGRTGTFVVIDAMLDMMHTER-KVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYL
.|. .   |    .|.||.||| ....    .|.|.  .|.   .  .|  | . ||   |. ..|  | || |
kysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 235-315 2.5e-17 56.8 In-house 19-95 (95) alignment
Range on Protein: 235-315
Range on HMM: 19-95/95.0
ADDNKLFREEFNALPACPiQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEgvpDSDYINASFINGYQEKNKFIAAQG
.. .. | .||....     |.  . | | |  |||..||.||| .|| ||      ||||||| |..||  || .|||||
snsdqefdnefksismts.gapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg

0036941 (Phosphotyrosine protein) phosphatases II 236-511 1.5e-99 328.3 In-house 10-286 (297) alignment
Range on Protein: 236-511
Range on HMM: 10-286/297.0
DDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLtpveGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT
... |...||  |. . .. ....|...||.||||| .||||||.||.|    . ..|||||||...||. |.||||.|||...||.|||||.||||. .
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

IVMVTNLKERKECKCAQYWPDQ--GCWTYGNIRVSVEDVTV--LVDYTVRKFCIQQVgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACN
|||.|.| |.   |||||||.   . .|||...| . .|.|  | |||.|..... .    . ...| .|.||.|.|||.||| .|  .|.|...|. ..
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt....gngesrtvthfhytgwpdhgvpespaslldfielvrkvl

PQ--YAGAIVVHCSAGVGRTGTFVVIDAMLDMMH---TERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEV
..    | ..|||||||||.|||...| ||....   .|..||.. .|  .| ||...||| .||.|.|.||||......| ...
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepl

0047943 (Phosphotyrosine protein) phosphatases II 236-501 6.1e-99 326.2 In-house 9-271 (273) alignment
Range on Protein: 236-501
Range on HMM: 9-271/273.0
DDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLtpveGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT
....|..|||..|. .... |...|...|||.|||| .|||||||||.|    | ..|||||||...||. |.||||.|||...||.|||||.||||. .
lgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMVTNLKERKECKCAQYWPDQG---CWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGdmtnRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNP
|||.|.| |..  |||||||. |    .|||...| . ....  |||||..... .|     .  | .|.||.|.|||.||| ..  .|.|...|. .. 
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg....tgesrtvthfhytgwpdhgvppslesllefielvrkale

Q--YAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
.    | .||||||||||||||...| .||....|..|||.  | ..| ||. ||||  ||.|.|.||||.
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley

0045098 (Phosphotyrosine protein) phosphatases II 236-506 8.1e-92 302.8 In-house 4-276 (278) alignment
Range on Protein: 236-506
Range on HMM: 4-276/278.0
DDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHltpvegvpdsDYINASFINGYqeKNKFIAAQGPKEETVNDFWRMIWEQNTAT
...  .. ||  |....|  ... | ...|..||||..|||||||||.          ||||||.|.||  ..||||.|||...||.|||||.||... .
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitv

IVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTP--IGMLKFLKKVKACNPQ
|||.|.|.|.. .|||||||..|..|||...| .....|| |||.|.. .. .  . .  ..| .|..|...|||.||| .|    .|..|. ..... .
ivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkl

-------------YAGAIVVHCSAGVGRTGTFVVIDAMLDMMhtERKVDVYGFVSRIRAQRCQ-MVQTDMQYVFIYQALLEHYLYGD
               | ..||||||||||||.|... ||...  |..||..  |. .| ||.. .||. .||.|.|..|||..|.|.
laslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 236-545 6.4e-91 300.0 In-house 15-319 (515) alignment
Range on Protein: 236-545
Range on HMM: 15-319/515.0
DDNKLFREEFNALPACPIQATCeAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT
    || |||. ||   |      | .| | .|||| |||||| .|| |  ..  |.|||.|||.|....  . .||.|||.. .|.||||.....|..|
rhttlfseefhdlpgpniypqt.vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvtt

IVMVTNLKERKECKCAQYWPD--QGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmtNRKpQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQ
|.|||.|||    ||..||||       .|.|.|..  .    . . ||. . .     . .  | .|||||| ||| |||     .||..|.||| . |
iamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlk.....gdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgq

YAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGL
|. ....|||||||||| .. || ..  ..| | |||. ||  ||..| ..|||. || |||.|.||. |. .| . |  .  ||| ..    |     .
ythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskm

EEEFKKLTSIKI
 .||. | |.  
tkefqtlkslcp

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 236-500 9.2e-60 196.9 In-house 13-291 (301) alignment
Range on Protein: 236-500
Range on HMM: 13-291/301.0
DDNKlFREEFNALPAcPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEG--VPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNT
  || | |....|     . .|.   .||||. ||. || .||. |. |.| .   .   .|||||.|.||.||.|||||||| ..|. ||||.||.. .
hsnk.feeqykelke.gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

ATIVMVTNLKERKECKCAQYWPDQG--CWTYGNIRVSVEDVTVLVDYTVRKFCI--QQVGD---------MTNRKPQRLITQFHFTSWPDFGVPFTPIGM
..|||||||||... || ||||.      ..|.. | . . .|. |...|....  |.. .         ....|  . ..|.. |.||. ||   |  .
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

LKFLKKVK-ACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
|. . .|  . .    | .|||||..|.|.|... ..  |.    |  |||.. . ..| ..  .|.|  ||..||... .
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 236-502 5.4e-46 151.7 In-house 3-259 (267) alignment
Range on Protein: 236-502
Range on HMM: 3-259/267.0
DDNKLFREEFNALPA-CPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEgvpdSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTA
|... ...||. .    ....|.     |.|.|.||. . ||||..|| |   |     .|||||...||. ||.||. |.| . |. ||. .| .|. .
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvp

TIVMVTNLKERkecKCAQYWPDQ--GCWTYGNIRVSVEDVTVLVDYTVRKFCIQqvgdMTNrKPQRLITQFHFTSWPdFGVPFTPigMLKFLKKVKACNP
.||..|.  .    .  ..|| .   .  | .. |         || .  . ..    . | .  . .| ...  |    .   |   || |  . | | 
vivlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelk....fkn.esahnvtlyyykkwn.intnnkp..ylkplfgilaknq

QYAG--AIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY
   |   .||.||.||||.|||.|||..|. . ||  .|.. |. .|| ||  .|.|  .|..|.. | |. 
lengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 236-500 1.6e-25 84.2 In-house 22-283 (302) alignment
Range on Protein: 236-500
Range on HMM: 22-283/302.0
D-DNKLFREEFNALPACPIQAT-CEAAskEENKEKNRYVNILPYDHSRVHLTpveGVPDsDYINASFINGYQEKNKFIAAQGPKEETV---NDFWRMIWE
  |.   ..||... .  ...  |.|    .| .||.  ..  .|. .| |.   . || .|.||| ..  . ... | || || ...   ..||||...
sldtaevkkefkkidtmkvdlekCkaf..kknlkknqsedvpildsnlvkle...aepd.syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfq

QNTATIVMVTNLKERKEcKCAQYWP-DQGCW-TYGNIRVSVEDVTVLVDYTvRKFCIQQVGDMTNRKPqrLITQFHFTSWPDFGVPFTPIGMLKFLKKVK
.. ...|..   .| |.    ...|  .| . .||...| .  |   .. .  ...|  . .     .  |..  ..| |..  ||     . |  .|| 
ekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsv..lanvyvltnWkqkkvpvkyaeliktaakvf

ACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
| . .    .|.    |.|| |.|..  . .. .... .. .   |  ||.||...|..  |||..| ||| 
akkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialll

subfamily_PTPN9_pd Subfamily PTPN9 238-504 2e-80 265.0 In-house 15-292 (297) alignment
Range on Protein: 238-504
Range on HMM: 15-292/297.0
NKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIV
..  ..|. .. . |.. | .|. .  | ||||| ..| ||..||.|. |.. . ||||||.|..||..|. |||.||| ..||.|||||.|||.. .||
krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv

MVTNLKERKECKCAQYWP--DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACN---P
|.| . ||.  ||.||||  .. .  .|...||. .| .  ||.||.. |..|    . . .| .| | |.||||.||| .   .|..|.||.       
mttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknv....kteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalav

QYA----------GAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLY
..             ||||||||.||||||. .|  |. .... .|||   |...|.||  ..||. ||.| |.|.||. |.
kelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale

subfamily_PTPN13_pd Subfamily PTPN13 238-500 2.8e-73 241.5 In-house 10-267 (273) alignment
Range on Protein: 238-500
Range on HMM: 10-267/273.0
NKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGvpdsdYINASFINGYQEKNK--FIAAQGPKEETVNDFWRMIWEQNTAT
..   |||. |     . ||| . |.|||.|||| |.||||..||.|    |     |||||.|.   .|..  .||.|||  |||.|||.|.|||..  
qqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaev

IVMVTNLKERKECKCAQYWPDQG---CWTYGNIRVSVEDVTVLVDYTVRKFCIQqvgDMTNRKpQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNP
|.|||. ||... || .|||..       .. ..|....|. | ...||.. ..   |.  ..  | .....|..||| ||| ..  .|.|...|.  . 
iamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavk...dsesge.srevahlnfvkwPdhgvPssaaellqfvaevrrlqt

qYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
  || ||||||||.||.||...||..|.... ....||   | ..| ||  .|||. ||.|.|.|.||
.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile

subfamily_CG7180_pd Subfamily CG7180 238-505 3.5e-68 224.4 In-house 16-293 (296) alignment
Range on Protein: 238-505
Range on HMM: 16-293/296.0
NKLFREEFNALPACPIqATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIV
. ... |..  |   |  .| .. ..||.||||.|...|||. || |. ..|  .||||||......  |...|  ..||.|||..|||....... ..|
rveyklelkltprlei.gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavv

MVTNLKERKEcKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQV----GD--MTNRKPQRLITQFHFTSWPD-FGVPFTPIGMLKFLKKVKAC
..|.  . .. .. .||| ..   ||.| | .  .  . . . |.| ...     ..       ..|....|..| |.    ||.   ........|.  
vLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlw

NPQY-----AGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYG
  .       | .||..| |..|.| .. ||| |.... | .|||...| ..| .| |.|..  .| .||. |||..| .
rekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn

subfamily_PTPRN_pd Subfamily PTPRN 238-500 2.5e-65 215.1 In-house 29-290 (297) alignment
Range on Protein: 238-500
Range on HMM: 29-290/297.0
NKLfREEFNALPACPIQ-ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKN-KFIAAQGPKEETVNDFWRMIWEQNTAT
..| ..|..|| |   . .|.|.|..|.| .|||. ..||||||||.|.      .|||||||.|   . ..  .||.|||  .|| |||.|.||| .. 
drl.ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvv

IVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDV-TVLVDYTVRKFCIQQVgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQY
||..|.|.|    .|..||||.|  .|.   | .        || || | ....    . .  | .||||| |||. ||| ..  .|.| .||  .    
ivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknl....qtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGr

AGAIVVHCSAGVGRTGTFVVIDAMLD-MMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
. .||||||.|.||||....|| .|. ...  ...|.   .  .| || ..|.|  |. |...|. |
scpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 238-501 1.8e-51 169.5 In-house 12-268 (281) alignment
Range on Protein: 238-501
Range on HMM: 12-268/281.0
NklFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTP-VEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATI
.  |..||  ||  |    | .  .  |..||||.||   | |||.|   .     .||| | .|     |  .| .||||.||  |||||||..||..|
d..fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

VMVTNLKERKECKCAQYWPDQ--GCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDmtnrkpQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACnpqy
||. .. | .  |||.|.| .   |  . .. || || ||       .. .   |.       ||||.. .  |||. || .   ||| |.|..|     
vmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyege......trlithwlwkewpdwqvpessevmlkilrkirar....

AGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERK-VDVYGFVSRIRA-QRCQMVQTDMQYVFIYQALLEH
.   |.||||||||.||.. ..  |. .|.     |.   ||..|   |.  |||  ||..|.. ||. 
stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

0049772 (Phosphotyrosine protein) phosphatases II 238-509 2.9e-51 170.4 In-house 19-287 (314) alignment
Range on Protein: 238-509
Range on HMM: 19-287/314.0
NKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDhSRVHLtPVEGVPDSDYINASFINGYqekNKFIAAQGPKEETVNDF----------WRM
.||. .  .  .  .   |. .|....|..|||| .|||.| .||.| | ..| .|||||||...|.   .||||.|||.|.||.||          |||
lklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrm

I--WEQNTATIVM---------------------VTNLKERKeckcaqywpdqgcwtY----------GnirvsvedvtvlvdytvrkfciqqvgDMT--
.  ...|. .|||                      ..| ..                                                      . .  
vlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...............neptaadlellk..........................eelyd

NRKPQRLITQFHFTSWPDFGVPfTPIGMLKFLKKVKACnpQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMhterKVDVYGFVSRIRAQRC-----QMVQT
. ...||. ... . .||...| ..  ...||. ....  .  |...|||.||.||||||||.. ..  .    .|..   ....|..|       ....
pelferlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieq

DMQYVFIYQALLEHYLYGDTEL
 .||.||..||||.. .  .. 
leqyefilealleylkflkkfy

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 238-304 3.4e-16 53.6 In-house 21-86 (440) alignment
Range on Protein: 238-304
Range on HMM: 21-86/440.0
NKLFREEFNALPACpIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGY
 . | .|.. ||.  ..  .. ||  .|| |||| ||| |||||| |  |.|||||||||||.||| 
srafedewsllpsg.lsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 239-508 1.2e-96 318.5 In-house 27-296 (298) alignment
Range on Protein: 239-508
Range on HMM: 27-296/298.0
KLFREEFNALPACPI---QATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT
  . .||. | .      ... |.|.|.|||.|||| .|...|.||| |. ...  .||||||||...|...| |||.|.| .|||.|||||..|.. .|
tgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigt

IVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKAcNPQYA
|||.|||.| .. |. .||||.|  |||.|.||.    .  |..|||. ...    .... .| . |.||||||| ||| .   .|..|.||.| ..| |
iVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvsk....kkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqa

G--AIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTE
|  ...|.|||||||.|||..||..|. ...|..|||.  | ..|..|...|||  ||||||.| ||    ...|
gnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 239-501 2.9e-73 241.3 In-house 5-267 (274) alignment
Range on Protein: 239-501
Range on HMM: 5-267/274.0
KLFREEFNALPACPiqaTCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGV-PDSDYINASFINGYQEKNK-FIAAQGPKEETVNDFWRMIWEQNTATI
| ...||  ||.     . |  .   ...|||| .||| ..||| |.. ..  .||.|||| .| ||.|..| ..|.|||  .||.||||||.....  |
kdlekeflelPlnf...dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi

VMVTNLKERKECKCAQYWPDQGCW----TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDmtN-RkpqrlITQFHFTSWPDFGVPFTPIGMLKFLKKVKACN
||.|.|||..| |||.|.||.       .||.. . ||...   ||.|||. .... .  . .     .. . .|.|||  .|  .  .|.....|.  .
vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ers.....vkhywytdWPdhksPddantlldlvleveesr

PQ---YAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
 .    ....|||||||.|||| |. |.  .  .. | .||| . |. .| .|  ||||. || .|..|| ..
eeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcly

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 240-503 1.2e-41 137.5 In-house 23-288 (305) alignment
Range on Protein: 240-503
Range on HMM: 23-288/305.0
LFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLtpvEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMV
 .|.||.|.         .|  . ....|||| ..   |. ||.|   ||    .|| | ..    . ..|| .| | |.|  ||| | ....  .| |.
glraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifml

TNLKERKECKCAQYWPDQGCW----TYGNIRVSVE-DVTVLVDYTVR-KFCIQQvGDMT---NRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKAC
 ||.|.   ||..|.. .         .. ..||  . .| ....   |  ...   ..     . .| .|..|.  ||| ||| . . .|..|.| .. 
cnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvte.tvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps

NpqyaGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVD-VYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYL
     | ||||||||.||||. |... .|| . . ....     . .|| || . .||| ||.|..| .|....
k....gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr

0046845 (Phosphotyrosine protein) phosphatases II 241-509 3.4e-100 330.3 In-house 2-281 (284) alignment
Range on Protein: 241-509
Range on HMM: 2-281/284.0
FREEFNALPACPIQA--TCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGV-PDSDYINASFINGY-----QEKNKFIAAQGPKEETVNDFWRMIWEQN
..||| .|. . .    ....| ..||..||||..|||||||||.|....|  .||||||||...||       |.||||.|||...||.|||||.||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TATIVMVTNLKERKECKCAQYWPDQG-CWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDmtnRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACN
. .|||.|.| |..  |||||||. | ..|||...| . ...|  |||||..... .|     .. | .|.||.|||||.||| .|  .|.||..|. ..
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy...tgesrtvthfhytswpdhgvppspedlleflrlvrell

P--QYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTER---KVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTEL
.   . | |||||||||||||||...| .|.....|.   .|||.. |.|.| ||..|||| .||.|.|.||||..... | |
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll

DSPc_SM00195 241-501 2.3e-92 304.4 In-house 2-261 (263) alignment
Range on Protein: 241-501
Range on HMM: 2-261/263.0
FREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVT
..|||. | .   . ... | |..||.|||| |||||||.||.|.. |. ..||||||..|.|...|.|.||.|||...||.|||||.||... .|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLKERKECKCAQYWPDQ--GCWTYGNIRVSVEDVTVLV-DYTVRKFCIQQVGDmtnrKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA
. .|... ||..|||..  | .|.|.|.| . .|.    ....|.. ... |.    . .| .||.....||| ||| ..  .|..|..|| .. .  | 
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk....eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

IVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
||||||||||||||||.|| .|. ...| |||.   |...| ||..||||..|| |||.|.|| 
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

PTPc_SM00194 241-501 2.3e-92 304.4 In-house 2-261 (263) alignment
Range on Protein: 241-501
Range on HMM: 2-261/263.0
FREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVT
..|||. | .   . ... | |..||.|||| |||||||.||.|.. |. ..||||||..|.|...|.|.||.|||...||.|||||.||... .|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLKERKECKCAQYWPDQ--GCWTYGNIRVSVEDVTVLV-DYTVRKFCIQQVGDmtnrKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA
. .|... ||..|||..  | .|.|.|.| . .|.    ....|.. ... |.    . .| .||.....||| ||| ..  .|..|..|| .. .  | 
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk....eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

IVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
||||||||||||||||.|| .|. ...| |||.   |...| ||..||||..|| |||.|.|| 
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 241-505 1.1e-46 154.3 In-house 18-280 (307) alignment
Range on Protein: 241-505
Range on HMM: 18-280/307.0
FREEFNALPAC-PIQATCEAASkeENKEKNRYVNILPYDHSRVHLTpVEGVpDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMV
...||. |    |   | || |   | .|||| ..   |..|. .. ..|.  |||| | ..    . .|||.||||.|.|. .|| |. ...  ...|.
lvdefrvlakktpegvtveafs..antdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

TNLKERKECKCAQYWPDQGC--WTYGNI--RVSVEDVTVLVdYTVRKFCIQ-QVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKAcnpQy
 .. |  . || |||| .     ..|.    .||... .    .  . .|.    ..   .  | |... .. ||| ||| . .. . .|. |.    . 
ckvielakikceqywpleegqklvfgeapntisvanlgakk.lapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry...d.

AGAIVVHCSAGVGRTGTFVVIDAMLD-MMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYG
   .||||||||||.|| | |  . | |.  .   |.  .|  .|.||   .||..||..... |||..|  
tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflel

subfamily_ptpA1_pd Subfamily ptpA1 242-461 5.5e-39 129.1 In-house 24-255 (418) alignment
Range on Protein: 242-461
Range on HMM: 24-255/418.0
REEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKnKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTN
.|||  |      .      |. |  |||| |||| .|.||.|  ..    |||||| .|.|   | .||..|||  .|. |||||.||.    |||.. 
keefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsr

LKERKECKCAQYWPDQGC----WTYGNI-----RVSVEDVTVLVDYTvRKFcIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNP
  |    || .|||.|        |||        ||| | |. |   |.  | .   .|     | |||...  |||. .|     . ..|. .   . 
esencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpe.rei.itrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

QY------AGAIVVHCSAGVGRTGTFVVIDAMLDM
|          |.|||||||||||||.    |.  
qiipssdrnvpiivhcsagvgrtgtfctavimmkk

subfamily_CG42327_pd Subfamily CG42327 242-430 1.6e-32 107.5 In-house 8-193 (319) alignment
Range on Protein: 242-430
Range on HMM: 8-193/319.0
REEFNALPacPIQATCEaASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQE-KNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVT
 |||. ||   . | .. .     |.|.|..|..|  ..|| |  .   . . |..||.. ||.. .| .|||| . |..  ||||..|||.. .|| .|
aeefrdlP..qliarad.evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

NLKERKECKCAQYWPDQ----GCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKpqrlITQFHFtSWPDFGVPFTPIGMLKFLKKVKAC
.| |    .||.|.| .    .  .||.|.|.. .  |   | .  . ...| .   |.    .| . .  |.. .||  .  ..  | .|.. 
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesre....lthywy.kwleaevPaeeaaliamllevrss

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 244-524 1.8e-98 324.6 In-house 3-277 (284) alignment
Range on Protein: 244-524
Range on HMM: 3-277/284.0
EFNALPACPIQA-TCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTnl
||....  .... . . |  ..||.|||...||..|...| | .. |.  |||||||||.||| |.|.||.|||...|..||||||||.|..|||..|  
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..

kerkECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNrkpQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACN--PQYAGAIVV
    . ||.|||| ..  .... .|.|. |.   .|.||.. . . | ...   .| |.||||  ||| |||  |. .....|||.  .   .    |||
....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekd...irkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivv

HCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNK
||||||||||...|.|..||.|. |..|||| ||  .| || ..||  .|| ||| ||||..|.| ... .  . ..|..  ||
hcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnk

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 244-524 1.3e-31 104.5 In-house 24-298 (312) alignment
Range on Protein: 244-524
Range on HMM: 24-298/312.0
EFNALPACPIQATCEAASKeeNKEKNRYVNILPYDHSRVHLTPVEGVpdsdYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLK
|..|.     .. | |  |   |. ||| ||  .|  |  |.  |      || | |..     ..|...||| |.|.  ||..     ...|.... . 
eykavgnivsdsectaflk..fkdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfv

ERKECKCAQYWPDQ-GCWTYGNIRVSVEDVTVLVDYTV-----RKFCIQQVGDMTNRKpqRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNpqyaGA
|    |||.|  |  |     . ||  | .| .           .  .. |   | ..    . .. ..|||| |.| .    |..|  ||  .      
edgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqe..sklnhyqwaswpdhgmpdscdtalrllsavkkdk....kp

IVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEhYLYGDTELEVTSLE-THLQKIYNK
.. |||||||||||...|..|.  .   || .|      .| .|.. |..  |||.  ...|| .||  .  .    | |.... | |
viahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvle.flyskglykrneqewtkfketyak

subfamily_PTPN3_pd Subfamily PTPN3 254-502 8.3e-68 223.3 In-house 30-275 (280) alignment
Range on Protein: 254-502
Range on HMM: 30-275/280.0
QATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEgvpdSDYINASFIN----GYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECK
. ...|| | || .|||| .|||||. ||.|.  |    .|||||...|    . .  |..||.||| ..|..|||.|.|||.. .|||.|.| ||   |
glaisaarkpenlsknryrdilpydatrvklkese....tdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

CAQYWPDQG-CWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGR
| ||||...  ..||...| .|       | .|......    .. | .| |.|. ...||| |||  .  .|.|...|...       .|||||||.||
ChqyWPetedeleygefsvkcekedetksyvlrelvlkd....ketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigr

TGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY
|| .....  | .. ....| .   |...| ||  .|||  || |. .|.|. |
tGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy

subfamily_PTPN1_pd Subfamily PTPN1 254-509 4.2e-65 214.3 In-house 21-280 (290) alignment
Range on Protein: 254-509
Range on HMM: 21-280/290.0
QATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGvpdsDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQY
. ....| ..||...||| .. ||||||..|   .     ||||||...  . | ..| .|||  .||. ||.|.|||.. ..||. .. |... |||||
dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WP-DQ--GCWTYGNIRVSVEDVTV--LVDYTVRKFCIQQvgdmTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKA--CNPQYAGAIVVHCSAGV
|| ..   . .. .....|. ..      ||||.. ...     . .  | |..||.|.||||||| .|  .|||| ||.   .  .  |  |.|||||.
wPqgeeekellledtklkvkliseerksyytvrllelen....lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

GRTGTFVVIDAMLDMMHTERK---VDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE--HYLYGDTEL
||.|||...|..|  .. . .   ||.   .  .| .|  ..||  |  | |.|.||  . . ||. .
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 254-502 9.2e-58 190.3 In-house 27-277 (287) alignment
Range on Protein: 254-502
Range on HMM: 27-277/287.0
QATCEAASKEENKEKNRYVNILPYDHSRVHLTpVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQY
 ||  || .  . .|||| ..||.|..|| |.  ||   |||||| .. .|.....|||||||   ||.||||...|...|.....|   |    || .|
tatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcyky

WPDQGC-WTYGNIRVSVEDVTVL-VDYTVRKFCIQQVgdmTNrKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKV-----KACNPQYAGAIVVHCSAGV
||..      |   | . | ...  .|.|| . . ..      .  |.. |... |||| ... | .|...|  .|      | . . .| .|||...|.
wPerevPmrvGGysvvlldydikePeygvralrlidl...et.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGi

GRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY
||.|... . ......    .|||   | |.| .|  .||. .|. ..|.||  .|
GrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 255-512 4.6e-36 119.2 In-house 25-279 (285) alignment
Range on Protein: 255-512
Range on HMM: 25-279/285.0
ATCEAASKEENKEKNRYVNILPYDHSRVHLTpvegVPDSDYINASFING-YQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQY
  |  .. | | . ||| ..   . .|| |       | ||| ||..    .... .|..|||  ||..|||.||.... | ..|.  | |    ||| |
pnctytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WPDQG--CWTYGNIRVSVEDVT--VLVDYTVRKFCIQQVGDMTNrKPQrLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAgAIVVHCSAGVGRT
.|..      .|.  ... ..    .    .  . . .  | .. .|   . . .   |||   |     |... | ||  ||.    |.||||||||||
ypeklgevvkfgkyeitlteckeeaiagtilnaltvintedass.epl.ymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrt

GTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEhYLYGDTELEVT
 ||| ||     .  . ....   |  .|| | | ||. ||..|.|  |.| |. |.  .| |
atfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlme.yfigegvvert

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 255-339 2.1e-09 31.3 In-house 27-116 (347) alignment
Range on Protein: 255-339
Range on HMM: 27-116/347.0
ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEG-----VPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMV
. . ..  | . .|||  .    | .|| |.| .       .   ||||| |.  . ....| .| |  .|| |||.|.   . . .| .
skftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti

0040439 (Phosphotyrosine protein) phosphatases II 256-502 5.2e-90 296.6 In-house 2-246 (249) alignment
Range on Protein: 256-502
Range on HMM: 2-246/249.0
TCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWP
... |...|||.||||..|||||||||.|....|...|||||||.|.||. |..|||.||| .|||.|||||.||..  .|||.|.|.|.. .|||||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQ--YAGAIVVHCSAGVGRTGTFV
..| ..||...| . .|.|. |||||..... .      .. | ......|.|||.||| ..  .|.|...|. .. .    | ..|||||||||||||.
lggsleygdftvtllsvevkddytvrtleltnl....ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

VIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY
... ||.....|..||..  |. .| ||...||.. ||.|.|.||||..
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_PTPN12_pd Subfamily PTPN12 256-500 6e-77 253.4 In-house 31-275 (290) alignment
Range on Protein: 256-500
Range on HMM: 31-275/290.0
TCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWP
. ||..||||..|||| .|||||.|||.|.  |....||||||.||.| ..| ..||||||  .|..||||||||.|.  .||. .. | .  ||..|||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

DQG--CWTYGNIRVSVEDVTVLV-DYTVRKFCIQQVgdmtnrKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTF
..|    ..|...|..|.   .  |...| . ...       | .| ..|||.|.||| ||| ..  .|.....|.  . . .  .||||||||||||| 
eegeeelefgefevtleeekavdddflirtLkveaq......kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGti

VVIDAMLDMMHTERK---VDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
..|| . .....|.    .||.  | ..| ||  .|||  ||...|.|..|
iaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae

0042113 (Phosphotyrosine protein) phosphatases II 257-501 5.6e-88 289.7 In-house 1-242 (245) alignment
Range on Protein: 257-501
Range on HMM: 1-242/245.0
CEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD
.. |...|||.||||..||||||.||.|.|..| .||||||||...||. ..||||.||| .|||.|||||.||..  ||||.|.. |.. .|||||||.
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

QGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNP-QYAGAIVVHCSAGVGRTGTFVVI
.. .|||...| . ....| |||||..... .      ...| ....|...|||.||| ..  .|.||. |. .      | ..|||||||||||||...
gesltygdftvtllseehlddytvrtlevtnl....gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa

DAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
. ||.....|..|...  | ..| ||...|||. ||.|.|.||||.
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel

0037934 (Phosphotyrosine protein) phosphatases II 257-501 6.1e-80 263.5 In-house 2-241 (243) alignment
Range on Protein: 257-501
Range on HMM: 2-241/243.0
CEAASKEENKEKNRYVNILPYDHSRVHLtpvegvPDSDYINASFINGYqekNKFIAAQGPKEETVND----FWRMIWEQNTATIVMVTNLKERKECKCAQ
.  |...||..|||| .|||||||||.|      ..||||||..|...   ...|| ||| .|||.|    ||||.||... .|||.|.|.|.. .||||
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPDQGcwTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmTN-RKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKAC--------NPQYAGAIVVHCS
|||..   |||...| . ....| |||||.....     ..  ...||....|...|||.||| .|  .|.||..|...        .    | ..||||
ywpgev..tygdftvtllseehlddytvrtlllen....ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs

AGVGRTGTFVVIDAMLDMMhterKVDVYGFVSRIRAQRCQ-MVQTDMQYVFIYQALLEH
||||||||..... ||...    .||..  | ..|.||.. .|||  ||.|.|.||||.
aGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 258-500 9.9e-70 229.4 In-house 1-239 (239) alignment
Range on Protein: 258-500
Range on HMM: 1-239/239.0
EAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNK-FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD
||| |  || |||| ||. |||||| |  .   | |||||||..  |.   | .||.||  | .  |||||.|..  . |||.| | | .. || |||||
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

QGCwTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTnrkpQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVID
     | |.||..    |. || .| | . |||.      .| . |.||| ||| |||     .| . .|.   .   |   |.||||||||||.|.|||
sts.kycnlrvtlrktevfadyiirtfvmsqvgqte....eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid

AMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
|||   . .. ||.. .|  || .| .||||  |||||. |.||
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_egg_pd Subfamily egg 258-511 5e-29 95.9 In-house 33-282 (307) alignment
Range on Protein: 258-511
Range on HMM: 33-282/307.0
EAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERkeCKCAQYWPDQ
. | ...|.|| |   .   | |||.|   .|    |.| |  ..|    |.|| || |  .||.|||||.....   |||.|  ||    .|  |||  
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka

G----CWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMtnrKPQRLITQFhFTSWPDFGVPFTPIGMLKFLKKVkaCNPqyagaIVVHCSAGVGRTGTFV
         |..|.   .|    |   |   .. ||     . .| .  .    .   .  ..|. .|. |...   .|     .||..  || ...|.|
esdslvtvpGslrienlkvdskadplfrvtklklvGgd...deerflehw.qgdvnnssdvysplrvlrklrnl..skp.....vvvqdilGvskaatlv

VID-AMLDMMHT-ERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALL---EHYLYGDTELEV
 |. |.|...     |  |   |  .| .|   |.. ..|.|.|. .|      .    ||.|
aieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldv

subfamily_eak_pd Subfamily eak 258-414 1.5e-18 61.3 In-house 45-195 (332) alignment
Range on Protein: 258-414
Range on HMM: 45-195/332.0
EAASKEENKEKNrYVNILPYDHSRVHLTPVEGVPDsDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ
. ... |. ..|  |.|.|||.  |.||.    ..  ||||| ..  .  .|.| .  ..|. |  ||.|. ||.. .||.. .  | |  |  .|.||.
setarleavnrn.vvkivpydrylvrltssqlnrl.GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

G--CWTYGNIRVSVEDVTVLVDYTVRKFCIqQVGDMTNRkpqrlITQFHFTSWPDFGVP
.   . .| . |   .      . .|.. . ..|. | |     .  ...  | .. .|
treelkfGildverkefvkrniletrllel.skGnethr.....vlhykvfGwtettlp

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 259-500 3.1e-69 227.8 In-house 1-238 (239) alignment
Range on Protein: 259-500
Range on HMM: 1-238/239.0
AASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNK-FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ
|| |  || |||| ||. |||||| |  .   | |||||||..  |.   | .||.||  | .  |||||.|..  . |||.| | | .. || ||||| 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

GCwTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTnrkpQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDA
    | |.||..    |. || .| | . |||.      .| . |.||| ||| |||     .| . .|.   .   |   |.||||||||||.|.||||
ts.kycnlrvtlrktevfadyiirtfvmsqvgqte....eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida

MLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
||   . .. ||.. .|  || .| .||||  |||||. |.||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 259-503 1.6e-39 130.3 In-house 49-290 (305) alignment
Range on Protein: 259-503
Range on HMM: 49-290/305.0
AASKEENKEKNRYVNILPYDHSRVHLTpveGVPDSDYINASFINGY-QEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD-
  | . .. |||| ..   |.| |.|      . |||| | ..      ...||.|||| ..|...|| |. ...   |||. .  |    |||||||  
nqsadiaitknryqdvpcqdqsavkld...kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaa

QGCWTYGNIRVSVEDVTVLVDYtVRKFCIQQ-VGDMTNRKPQRL-ITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNpqyaGAIVVHCSAGVGRTGTFVV
||     .  . ||.|.       |   ||  . ..|    |.. . ....| ||| |||   .  |..|  ..  .      ||||||||.||||| | 
qgeklelksgivvenvsgskpm.erdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtiva

IDAMLDMMHTERKVD-VYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYL
|. .|. .  ....  .  .|  .| ||.  .|.|.||.||.. .|...|
ieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 260-501 2.3e-90 297.2 In-house 4-241 (250) alignment
Range on Protein: 260-501
Range on HMM: 4-241/250.0
ASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECkCAQYWPDQGC
| | .||||||| .|...|.||| | ...|  .||||||||..||.|.. |||.||| ..|..|||||..|....||||.||||| ..  . |||| .. 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

WTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQ-YAGAIVVHCSAGVGRTGTFVVIDAM
 .||...||. .  .  |||.||. . .    .... .|.. |.||..||| ||| .   .|..||||.| ..|  .. ..|.|||||||.|.|..|||.
ekyGdvtvsllskeefadytkrklklsk....akkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

LDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
|. ...|..|||. .. ..|..| ..|..  ||||.|...|. 
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 261-430 1.4e-36 120.9 In-house 29-196 (297) alignment
Range on Protein: 261-430
Range on HMM: 29-196/297.0
SKEENKEKNRYVNILPYDHSRVHLTpvEGVPDSDYINASFINGYQEKN--KFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQG
 ..    |||| .|| .| .||.|    .....||||| ..   .|..  |.| |||| ..||.|||....||.  .||||..|.|    ||| |||.  
krnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

CWTYGNIRVSVEDVTVLVDYtVRKFCIQQVgDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKAC
        | || ..   |    .  . ..  .  |. .| ..   | |||| |||     . .|  .| .|
qerlkagdvvveflsstsde.fdrviltel.qliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcsc

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 262-500 3.1e-48 158.9 In-house 53-281 (290) alignment
Range on Protein: 262-500
Range on HMM: 53-281/290.0
KEENKEKNRYVNILPYDHSRVHLTpvEGVpDSDYINASFINGYqeKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQG--C
|. . .|||| ..   | .|| |   .|  | ||. | ...|   |  || .||. ..|| |.|||. ....|.|||. .| |    ||.||.|..    
kntefkknrykdvvcndktrvilk..dGy.dGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

WTYGNIRVSVEDVTVLVDYTVRKfcIQQVGDMTNRKPQRLiTQFHFTSWPDFGVPFTPIGMLKFLKKVKACnpqyAGAIVVHCSAGVGRTGTFVVIDAML
 |.|.| |     .   . ...|  .  | |. . |  .|   ..  ||||  |. . . .|. |. ..      .| .|||||||.||||||| |.. |
ltfGeitvlcseeddkdaniikk..tlsvrdkdsGkehkl.khlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievgl

DMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
...   ...|. . |  .|  | . || |.||. . ..||.
qilldGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 263-501 9.2e-65 213.3 In-house 18-263 (270) alignment
Range on Protein: 263-501
Range on HMM: 18-263/270.0
EENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQE-KNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDqgcWT
  .|. ||| .|||  ..|| | ..|  . . |||| ...|... |.|.|||.||.. |...|||||||... .|||.|.|.|.   ||..|||     .
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa...ep

YGNIRVSVEDVTVLVDYTV-RKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPI------GMLKFLKKVKACNPQYA--GAIVVHCSAGVGRTGTF
  .....  ...||.  .. ... |..   ....  .| .. |....||| ||| ..        .|| |..|.. . . .  . ..||||||||||||.
kekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

VVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
...| .. ......||||   ....| .|...||.  || |.|.|..|.
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 263-500 3e-33 109.7 In-house 50-288 (310) alignment
Range on Protein: 263-500
Range on HMM: 50-288/310.0
EENKEKNRYVNILPYDHSRVHLTpVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGC-WT
...  |||| ...  | |||.|. ..     ||| | ...    .. || .||| . |. ||||||... . .|... .  |    ||  |||  |   |
kkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

YGNIRVSVEDVtVLVDYTVRKFCIQQVGDMT--NRKPQRL----ITQFHFTSWPDFGVPFTPIGMLKflKKVKACnpQYAGAIVVHCSAGVGRTGTFVVI
|| |||.        .. . ....  | |    . .|  |    ..  ..  ||| |||      .   ... |      |  |||||||..|... | .
ygcirvtnlse.sseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrllaq..vrhgpcvvhcsagkdrlyvvval

DAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
.  .| ..   |||.   .. .. .| . .||..||..| .  . 
klkidkldrglkvdaeevktellksraiciqtelqyliidrvrii

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 264-500 1e-68 226.1 In-house 2-237 (237) alignment
Range on Protein: 264-500
Range on HMM: 2-237/237.0
ENKEKNRYVNILPYDHSRVHLTPVEGVpdSDYINASFINGYQEK-NKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQG-CWT
||| |||| ||  |||||| |    .   ||||||....|..   .|.|||||| | . .|||.|.|... . |||.| | |..| || .|||.     .
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGNIRVSVEDVTVLVDYTVRKFCIQQVGDmtnRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQ--YAGAIVVHCSAGVGRTGTFVVIDAML
|| . ||.     . ||||| . ... .     |  ||| |..|||||| |||     .|.| |..   .|    .|  ..|||||||||| |.||||||
ygvltvslkkkeefsdytvrslllskrlt...lkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

DMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
   . .. ||.| .|  |  .|  ..||  |||||.|..||
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 264-503 3.1e-36 119.9 In-house 42-272 (288) alignment
Range on Protein: 264-503
Range on HMM: 42-272/288.0
ENKEKNRYVNILPYDHSRVHLTpvegvPDSD-YINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTY
.|  ..|| |.   | .||.|.      |.| ||.|  .   . |...| || | . |.. .|.|. |..   |||...| |.   | |.|.| .   . 
anptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

gNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNpqyaGAIVVHCSAGVGRTGTFVVIDAMLDMM
  |.    .| .  .   .   .  .    . . . .. . |.  |.| |||   .  |..|. .|...      ||||.|||||||||...|  .|...
.rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililialesl

HTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYL
  .  . .  .... |..| . .|| |||..... .||. |
rlddflgirsllaklreerfkaiqtemqylyvhrcvleell

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 264-369 5.5e-14 46.2 In-house 47-165 (349) alignment
Range on Protein: 264-369
Range on HMM: 47-165/349.0
ENKEKNRYVNILPYDHSRVHLTP----V----------EGVPDSDYINASFING--YQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKE
|   |||| .||||.|||| |                 ..    ||||| ...   .. ..|.|| | |   ||.||...|  ..   .. ... ||   
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

CKCAQYWPDQgcwTYGNIRVSV
 || .|| .    .| ||.| .
ekcdiywqel...sysnitvkl

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 264-420 9.3e-10 31.7 In-house 26-161 (169) alignment
Range on Protein: 264-420
Range on HMM: 26-161/169.0
ENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINAsfingyqeknkfiaaqgpkeetvndfwRMIWEQNTATIVMVTNLKERK----ECKCAQYWPD--Q
 |. |||    |   | ||.|  |     ||||||                           ||||| |.. ||.. .  ..     | .  |  |    
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavil

GCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGM
| |    . |  . |.....     | .  |    ...    .. .|...||. ||| .|. .
gewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhv

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 264-422 6.2e-09 28.9 In-house 25-162 (169) alignment
Range on Protein: 264-422
Range on HMM: 25-162/169.0
ENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINAsfingyqeknkfiaaqgpkeetvndfwRMIWEQNTATIVMVTNLKERK----ECKCAQYWPD--Q
 |. |||    |   | ||.|  |     ||||||                           ||||| |.. ||.. .  ..     | .  |  |    
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpavil

GCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLK
| |    . |  . |.  .      | .. | .  ...  . .. .|...||. ||| .|. . .
Gewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvgh

Y_phosphatase Protein-tyrosine phosphatase 265-500 1.1e-85 282.2 Pfam-A 1-235 (235) alignment
Range on Protein: 265-500
Range on HMM: 1-235/235.0
NKEKNRYVNILPYDHSRVHLtpvEGVPD-SDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWP--DQGCWT
||.|||| .|||||..||.|   .| .. ||||||....||.||.||||.||| ..|..|||||.|.... .|||.|.|.|... |||||||  ...  |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGNIRVSVE-DVT-VLVDYTVRKFCIQQVGDMTnrkPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAML
||.|.| .. ...    .||.||. ... .. .    .| ..|.|.|.||| ||| .| ..|....||.  . .  | .|||||||||||||||..|..|
ygdikvelkekekedekeytlrklelkkkkees...ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

DMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
.....|..|||. .|...|.||..|||.  ||.|.|.|.||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 265-500 1.1e-85 282.2 In-house 1-235 (235) alignment
Range on Protein: 265-500
Range on HMM: 1-235/235.0
NKEKNRYVNILPYDHSRVHLtpvEGVPD-SDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWP--DQGCWT
||.|||| .|||||..||.|   .| .. ||||||....||.||.||||.||| ..|..|||||.|.... .|||.|.|.|... |||||||  ...  |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGNIRVSVE-DVT-VLVDYTVRKFCIQQVGDMTnrkPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAML
||.|.| .. ...    .||.||. ... .. .    .| ..|.|.|.||| ||| .| ..|....||.  . .  | .|||||||||||||||..|..|
ygdikvelkekekedekeytlrklelkkkkees...ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

DMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
.....|..|||. .|...|.||..|||.  ||.|.|.|.||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

0041856 (Phosphotyrosine protein) phosphatases II 265-508 1.7e-56 186.0 In-house 1-177 (182) alignment
Range on Protein: 265-508
Range on HMM: 1-177/182.0
NKEKNRYVNILPYDHSRvhltpvegvpDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTnlkerkeckCAQYWPdqgcwtygn
|..||||..||||||||          |.|||||... |..  ..|||.|||  .||.||.||..|..  |||..|         . .|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

irvsvedvtvlvdytvrkfciqqvgdmtnRKPQRLITQFHFTSWPDFGVPFtPIGMLKFLKKVKAcnpqYAGAIVVHCSAGVGRTGTFVVIDAMLDMmht
                              . .||..|.....|||.|||  .  .|.|...|..      |...||||||||||||.|... |. .   
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl...

erKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTE
  .|...  |. .| .|..||.|  ||.|...||||..|...|.
..gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 265-493 1e-31 104.8 In-house 50-272 (301) alignment
Range on Protein: 265-493
Range on HMM: 50-272/301.0
NKEKNRYVNIlPYDHSrvhlTPVEGVPDSD--YINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGC--W
.|.|.|| .. | . |    | || . |     | | .|.   . ..|||.||| ..| .||| |.   .  .|||...  |..| ||..| | .     
pkdkhryptv.PckPs....tavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekl

TYGNIRVSVEDVTVLVDYTVRKFCIqQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNpqyaGAIVVHCSAGVGRTGTFVVIDAMLD
  |  .. ...  ....  . |  . .| | |.. . | .| . ...|.| ||| . . . .... ||  .      ||||||||.||. .|.  . .  
digrfkikiknkelilnkkiskrtl.evedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylar

MMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVF
 .........   . ..| .| . |||  |  .
eveadptieltealkhlrehrwngvqtnsqlyw

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 265-358 1.6e-24 81.3 In-house 47-154 (350) alignment
Range on Protein: 265-358
Range on HMM: 47-154/350.0
NKEKNRYVNILPYDHSRVHLT----PVEG----VPDSDYINASFINGY----QEKNK--FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKC
   ||||.|||||.||||.|     . ..    .  .|||||....      . . .  .||.|.|  .||.||...| . .   |...|.. |    ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

AQYWPDQG
 .||.. .
yrYWqegs

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 265-356 8e-14 45.8 In-house 34-124 (332) alignment
Range on Protein: 265-356
Range on HMM: 34-124/332.0
NKEKNRYVNILPYDHSRVHLTPVEGvpDSDYINASFINGYQEKNKFIAAQGPKEE-TVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD
| . ||   .  .||||| |.| .|    |. |||...|| .|. .| || | .. |   ||||. |.. . |... .. |... |.     |
nmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisd

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 269-503 5.9e-22 73.1 In-house 23-257 (290) alignment
Range on Protein: 269-503
Range on HMM: 23-257/290.0
NRYVNILpYDHSRVHLTPVEGVPDSDYINASFINgYQEKNKFIAAQGPKEET-------VNDFWRMIWEQNTATIVMVTNLKERKEC----KCAQYWPDQ
.|. . |   ..|| |        .||| |...  . .  ..|. | |.|..       ...|| |. . .   .||. . .|...      ||.| |..
qRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

G--CWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKaCnpqYAGAIVVHCSAGVGRTGTFVVI
     ..... |.  .     |  .|. ...      . . .  .|   . .| .  |. ... .|. ..||| .   .  ...|||  |. |  ..  |
vgeelkfkgltvkCkskekeddvetRelvvkf.....ddeeeftvtHsllkgWnklnvqedtktllsliqkvk.a...sktpvivHcvdGiSrsAalaai

DAMLDMMH-TERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLehyL
.    ..  |. .| .   .. .| || ......... |.  ...   |
ilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv...l

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 275-412 2e-10 35.1 In-house 3-125 (130) alignment
Range on Protein: 275-412
Range on HMM: 3-125/130.0
LPYDHSRVHltpvegvpDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKEckcaqYWPDQGCWTYGNIRVSVEDVTV
|... ||..        . .||||||.   .  .... .| |  .|  |||.|. |.    .|..  ..|  |     ||||     . . .. |     
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdr

LVDYTVRKFCIQQVGDMTNrKPQrLITQFHFTSWPDFG
     ..   ..   |. .   |  .| |. . ||  |
defknikasnleiesdlne.shq.altmfqisnwpsdg

0044763 (Phosphotyrosine protein) phosphatases II 276-506 1.9e-42 140.3 In-house 1-175 (178) alignment
Range on Protein: 276-506
Range on HMM: 1-175/178.0
PYDHSRVHLTPVEGVPDSDYINASFINGYqeknKFIAAQGPkeetvNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCwtygnirvsvedvtvl
|.|..||.|...||.. |||||||.| ..     ......|      |......|..  .||..|. .|.  .|| .|||..                  
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

vdytvrkfciqqvgdmtnrkpqrliTQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMmhterKVDVYGFVS
                          |.... .||.|||  .  .|.|.. .... ..  |...|||||||||.||.|... |. .     .....  ..
.........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

RIRAQRCqMVQTDMQYVFIYQALLEHYLYGD
..|..|. .|... |. ..|.  |... ..|
lvrerRp.ivpnpgqlrqLyefelrllkesd

0046846 (Phosphotyrosine protein) phosphatases II 285-500 6.6e-46 151.6 In-house 4-171 (176) alignment
Range on Protein: 285-500
Range on HMM: 4-171/176.0
TPVEGVPDSDYINASFINGYqeknKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDqgCWTYGNirvsvedvtvlvdytvrkfc
..    .|.|||||..| |.    ..|| ||| ..|. ||..|..|..  ..|..|...| . .||..|||.  ....|                     
rllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi....................

iqqvgdmtnrkpqrlitQFHFTSWPDFGVPFTpIGMLKFLKKVKACNPQYaGAIVVHCSAGVGRTGTFVVIDamldMMHTERKVDVYGFVSRIRAQRC-Q
                 |.... |||.|||     .|..|. .. .  .  | ..||||||.|||||.|...    ....|. ..|.  ....|.||. .
.................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplg

MVQTDMQYVFIYQALLE
.|||. || |.|...|.
avqtpeQyrflyefell

0051429 (Phosphotyrosine protein) phosphatases II 291-524 6.1e-57 188.6 In-house 2-246 (272) alignment
Range on Protein: 291-524
Range on HMM: 2-246/272.0
PDSDYINASFINGYQE---KNKFIAAQGPKEETVNDFWRMiWEQNTATIVMVTNLKERKECKCAQYWP------------DQGCWTYGNIRVSVEDVTVL
| |.||||....||     ........|| . |..||||. .|..  |||..... ||. .|| .|||            .    .||..|| .  ...|
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

VDYTVRKFCIQQVGDMTNRkpqRLITQFHFTSWPDFGVPFTPigMLKFLKKVKAcnpqyAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVD------
 ||..|....  . ....    | ....|.|.|||.|||  .  .|..|. . .      |...||||||..||||.|... .|  .. |  ||      
ldyilrellltlllsagea...revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--VYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHyLYGDTELEVTSLETHLQKIYNK
  ....|...|||| ..|||..||.|.|.||||  |.. .. ..  |...|. | ..
lyleeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaidee

0043147 (Phosphotyrosine protein) phosphatases II 291-496 8.7e-47 154.3 In-house 3-155 (172) alignment
Range on Protein: 291-496
Range on HMM: 3-155/172.0
PDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLkerkeckcaqywpdqgcwtygnirvsvedvtvlvdytvrkfciqqvgD
..|||||||....|   ..||| |||  .|..|||||..|..  .||..|.|                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................l

MTNRKPQRLITQFHFTSWPDFGVPfTPIGMLKFLKKVKA-CNPQYAGAIVVHCSAGVGRTGTFVVIDAMLdmmhteRKVDVYGFVSRIRAQRCQMVQTDM
 .  . .||. |.....|||.||| ..  .|.||. ..  .. .  |...||||||||||||.|... ||      ......  |. .|..|...||.. 
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYVFIYQ
|| |.|.
qyrflyy

0051082 (Phosphotyrosine protein) phosphatases II 291-499 2.8e-38 126.2 In-house 1-150 (151) alignment
Range on Protein: 291-499
Range on HMM: 1-150/151.0
PDSDYINASFINGYqeknkFIAAQGPkeetVNDFWRMIWEQNTATIVMVTNLKERKecKCAQYWPDQGcwtygnirvsvedvtvlvdytvrkfciqqvgd
| |||||.|.. |.     ... .||     .||.....|..  |||......||.  .|..|.|..|                                
plsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

mtnrkpqRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKAcnpQYAGAIVVHCSAGVGRTGTFVVIDAMLdMMhterkVDVYGFVSRIRAQRCQMVQTDMQ
       . ........|||.|.| ..  .|.||... .   .  | ..||||||.|||||.|... || ..     |...  .. .|..|. .||. .|
.......ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqq

YVFIYQALL
..|...|||
flfqlfall

0036282 (Phosphotyrosine protein) phosphatases II 293-496 9e-51 167.3 In-house 2-164 (174) alignment
Range on Protein: 293-496
Range on HMM: 2-164/174.0
SDYINASFINGYQEKNKFIAAQGPKEetvndFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDqgcwtygnirvsvedvtvlvdytvrkfciqqvgdmT
|||||||.....   ...|| ||| .     ||.|..|..  |.||....||.. .|| .|||.                                   .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................l

NRKPQRLITQFHFTSWPDFGVPFTPIgMLKFLKKVKACNPQ-YAGAIVVHCSAGVGRTGTFVVIDAMLDMMHtERKVDVYGFVSRIRAQRCQMVQTDMQY
   . ||. |.... |||.||| ..| .|.|.| |. .  .   | ..||||||||||||.|... || ... |. ||.. .| ..| ||..||||. ||
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

VFIYQ
 |.|.
rflyy

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 293-412 5.8e-10 33.2 In-house 122-234 (244) alignment
Range on Protein: 293-412
Range on HMM: 122-234/244.0
SDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKEckcaqYWPDQGC--WTYGNIRVSVEDVTVLVDYTVRKFCIQqvGD
  ||||||.       ..| .| |  .|  |||.|. |.    .|..  ..|  |     ||||     |   .| |.. |   . .    .. |.   |
ntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdseplewyeeditvtltdrdefknikasnleie..sd

MTNrKPQrLITQFHFTSWPDFG
| .   |  .| |  . ||  |
mne.shq.altmfqisnwpsdg

0049260 (Phosphotyrosine protein) phosphatases II 300-496 1.3e-43 143.6 In-house 1-144 (152) alignment
Range on Protein: 300-496
Range on HMM: 1-144/152.0
FINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWpdqgcwtygnirvsvedvtvlvdytvrkfciqqvgdmtnrkpqrl
||.||  ...|||.||| ..|..|||||..|..  ||||.|.| |....||.||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

itQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLdmmhteRKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQ
  |.... |||.|||  .. .| .|. .. .. .  | ..||||||||||||.|... ||      ..|... .|...|..| ..|..  |. |.|.
..qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 302-366 1.3e-11 38.5 In-house 230-292 (440) alignment
Range on Protein: 302-366
Range on HMM: 230-292/440.0
NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERkecKCAQYWPDQ-GCWTYGNIR
.||  || |||.| | . || ||||.. . . .||.|. .|...    |. ||| .    |.| . 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpft

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 305-500 2.5e-07 23.6 In-house 112-307 (346) alignment
Range on Protein: 305-500
Range on HMM: 112-307/346.0
QEKNKFIAAQGPK---EETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNiRVSVEDVTVLVDYTVRKFCIQQVGDMtNrkPQRLIT
| ..|.| || |.   |  |.||| ||....   . ..      |.   . .  ..| . |   .. ...    |    ... |. . .  |   . .| 
qfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytg.kmfinnrradvsgdpkeytievlpeg.n..sdsvic

QF-HFTSWPDFGVPFTPIGMLKFLKKVKACNP-QYAGAIVVhCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALL
|  | . |  .  |   . ..|.... .. .  | ||  ||    | ||. .|.     .. .    . ...  .  |. ||   |..  ||  ||  ..
qvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivf

E
.
d

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 306-494 1.9e-28 93.8 In-house 88-280 (302) alignment
Range on Protein: 306-494
Range on HMM: 88-280/302.0
EKNKFI-AAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ--GCWTYGNIRVSVEDVT-VLVDYTVRK-F---CIQQVGDMTNRKPQ
.|.|       || .|.. .| .| . |.| .| .....| .| |||.|. |.  |  ..|.  |   .|   | ..| .| |    ..   . ...| .
kkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvk

RLITQFHFTSWPDFGVPFTPIGMLKFLkkvKACNpQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFI
. .  ..|..||| | |  .   |. |   | |.  |  ...||||||||||||.| |   ...  ...  |.   |  .|. |   ||.. | ...
ktvdilafsawpdhGapkeaytaldil...kfce.sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 307-496 4.6e-29 96.0 In-house 4-198 (199) alignment
Range on Protein: 307-496
Range on HMM: 4-198/199.0
KNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD--QGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgDMTNRKPQRLITQFH
. ..||.| |  ||. |||.|.||  .  |||| . .  ||.  . |||    |.  ||.. |... .|.  |||.  . . .  . |     | |... 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltn..nttappstreishyq

FTSWPDFGVPFTP--IGMLKFLKKVKACNPQY-AGAIVVHCSAGVGRTGTFVVIDAMLDmMHTERK---VDVYGFVSRIRAQRCQMVQTDMQYVFIYQ
|||| .   |     .|..   ..|     |     ..|||| | | || || .|  .   | | |   ||..    |.|  || .. .  .| ||||
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvr.sheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 307-496 4.8e-29 95.9 In-house 3-197 (198) alignment
Range on Protein: 307-496
Range on HMM: 3-197/198.0
KNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD--QGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgDMTNRKPQRLITQFH
. ..||.| |  ||. |||.|.||  .  |||| . .  ||.  . |||    |.  ||.. |... .|.  |||.  . . .  . |     | |... 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltn..nttappstreishyq

FTSWPDFGVPFTP--IGMLKFLKKVKACNPQY-AGAIVVHCSAGVGRTGTFVVIDAMLDmMHTERK---VDVYGFVSRIRAQRCQMVQTDMQYVFIYQ
|||| .   |     .|..   ..|     |     ..|||| | | || || .|  .   | | |   ||..    |.|  || .. .  .| ||||
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvr.sheesktsvvdlfevakrlrqarcgiisslqhynfiyq

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 312-511 1.2e-19 65.4 In-house 39-229 (255) alignment
Range on Protein: 312-511
Range on HMM: 39-229/255.0
AaqgpkeeTVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD--QGCWTYGNIRVSVEDvtVLVDYTVRKFCIqqVGDMTNRKPQRLITQFHFTSWP
        ||. |...|  ..| ..||.....| .  || .|.|   ..   . .. |.. .     |  .|   |  .  ....|  . .. .... |.
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtlei..tstlgekkkthtvkhysykGWi

DFGVPFTPIGMLKFLKKVKACNPqyagaIVVHCSAGVGRTGTFVVIDAMLD----MMHTER--KVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYl
.   |  .  .|. || |.   .     .|||||.|.||. .||... .       ..|    ..|   ..  .| .| . ..| .|  |    .|. . 
eknaPelareilnilkvvrdsks.....vvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv.

YGDTELEV
.  .||| 
fpkgelea

subfamily_hpo-7_pd Subfamily hpo-7 319-512 6.9e-17 56.2 In-house 45-237 (263) alignment
Range on Protein: 319-512
Range on HMM: 45-237/263.0
ETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD--QGCWTYGNIRVSVEDVTVlvDYTVRKfcIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFT
.|.. |...|  ..| ..||... .|    || .|.|    .   . |. |.. .|    |  ..   .. .  . ..|  . .... .. |..   |  
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllkt..lellstlgeKkkthtvkhysykgWiekndpel

PIGMLKFLKKVKACNpqyagAIVVHCSAGVGRTGTFVVIDAMLD----MMHTER--KVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELE
.. .|. || ..         .|||||.|.||.  |.|.. .       ..|    ..|   ..  .| .| . ..| ||  |    .|.  |   .. |
areilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakge

VT
. 
le

0048076 (Phosphotyrosine protein) phosphatases II 353-500 5.9e-27 89.5 In-house 2-141 (145) alignment
Range on Protein: 353-500
Range on HMM: 2-141/145.0
YWPDQ--GCWTYGNIRvSVEDVTVLVDYTVRK-FCIqqvgDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYaGAIVVHCSAGVGRT
|||..  . . .|..  ...|.  | |. ..  ...     .. . . ||..|.....|||.|||  .  .|.||. .... ..  | ..||||||||||
ywpseilpglylgslp.taldlellkdlgittvlnl....tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRt

GTFVVIDAMLDmmhteRKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
||.|... ||      ..|...  . ..|.|| ..|... |. |.|...||
gtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefele

0048179 (Phosphotyrosine protein) phosphatases II 362-496 6.8e-26 86.1 In-house 13-139 (144) alignment
Range on Protein: 362-496
Range on HMM: 13-139/144.0
YGNIRvSVEDVTVLVDYTVrKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYaGAIVVHCSAGVGRTGTFVVIDAMLdm
.|..  ...|.  | .. . .  |  . .  .  . | ..|.....|||.|||  .  .|.||. .... ..  | ..||||||||||||.|... |.  
lgslp.taldlellkklgi.ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk..

mhtERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQ
   .......  . ..|..|...|... |. |...
...klglsleealalvrsrrpgavpnpgqlrfLle

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 391-501 7.4e-14 45.8 In-house 212-343 (349) alignment
Range on Protein: 391-501
Range on HMM: 212-343/349.0
MTNRKPQRLiTQFHFTSWPDFGVPFTPIGMLKFLKkVKA-----------CNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTE----RKVDVY----
....||  |  |. .  |.| .. . || .|. |. ||             . .   ...|||||| ||||..| .| .|....       |...     
lavekPyel.lqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallk

----GFVSRIRAQRCQMVQTDMQYVFIYQALLEH
      |  .| || .|||   |...||.|||..
DlisiivnelrkqrismvqnlaqfiaiyealLky

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 397-539 1.6e-25 84.3 In-house 88-231 (440) alignment
Range on Protein: 397-539
Range on HMM: 88-231/440.0
QRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQ-YAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIY
 | . |.|. .||| |||     .||... |. .. .   | ..||||||.||||  ...|..|   .   ..|.. |.. .| .| |||||  ||.|..
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

QALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKK
.|.||  | ||| .    .  ....|    | | .. |..||. 
eavlegllcgdtliledditerveqiqwpnphtdksplqqefeg

PTPc_DSPc_SM00012 400-500 5.3e-36 118.4 In-house 2-105 (105) alignment
Range on Protein: 400-500
Range on HMM: 2-105/105.0
ITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYA--GAIVVHCSAGVGRTGTFVVIDAMLDMMHTE-RKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQ
....|.|.|||.||| ..  .|..|..|| .. . .  . .|||||||||||||||..| .|.....| ..||.. .|...| || .||||..||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 400-501 3.9e-18 60.3 In-house 217-343 (350) alignment
Range on Protein: 400-501
Range on HMM: 217-343/350.0
ITQFHFTSWPDFGVPFTPIGMLKFLK-KVK----AC-----NPQYAGAIVVHCSAGVGRTGTFVVIDAMLD---M----MHTERKVDVY--------GFV
. |...  |.| .. . |. .|. |. | .     .     . . . .|.||||||||||||.| .| .|    .     .  ||.||           |
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

SRIRAQRCQMVQTDMQYVFIYQALLEH
 ..| || .|||.  |..|||.||| .
nelrkqrismvqnldqfifiYeallfy

subfamily_PTPDC1_pd Subfamily PTPDC1 402-494 4.2e-09 31.1 In-house 84-168 (182) alignment
Range on Protein: 402-494
Range on HMM: 84-168/182.0
QFHFTSWPDFGVPfTPIGMLKFLKKVKACnPQyAGAIVVHCSAGVGRTGtfVVIDAMLdmMHTeRKVDVYGFVSRIRAQRCQMVQTDMQYVFI
 ..  .|.|.||. .   .|   | |. .  |  |.. ||| || ||||  |.| ..|  ... ....    .. .|..| . .||  |  ..
yvynfgwkDygva.sleriLdivkvvafa.lq.egkvavhChaGlGrtG..vliacyl..vya.krltaekaiklvrskrpksiqtreqvelv

0038934 (Phosphotyrosine protein) phosphatases II 403-455 1.8e-08 29.8 In-house 82-135 (194) alignment
Range on Protein: 403-455
Range on HMM: 82-135/194.0
FHFTSWPDFGVPFTPIGMLKFLKKVKACNPQY-AGAIVVHCSAGVGRTGTFVVI
..   .||.|.. .   .|.||. |.  . .   |...||| ||.|||||.|. 
ylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa

subfamily_DSP23_pd Subfamily DSP23 404-496 3.5e-06 21.7 In-house 55-140 (148) alignment
Range on Protein: 404-496
Range on HMM: 55-140/148.0
HFTSWPDFgVPFTPIGMLKFLKKVKACNPQyAGAIVVHCSAGVGRTGTFVVIdamldMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQ
.    .|.  | ..  . .|.. |.  . . . |. |||  | |||||..        .  |||.     .. .| .|   |.|  |   ...
vrlriddy.hppaleqvvefvrvveeaeek.neavsvhcllgrgrtgtmlac.....ylvkerklaaaeaiaevrrlrpgsvetveqeklvrd

PTEN_1 407-454 8e-07 24.1 In-house 101-149 (196) alignment
Range on Protein: 407-454
Range on HMM: 101-149/196.0
SWPDFGVPfTPIGMLKFLKKVKACNPQ--YAGAIVVHCSAGVGRTGTFVV
...|.|.| .   .....|... .  .    ....||| ||.||.|| | 
pieDhgap.slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva

subfamily_CDC14_pd Subfamily CDC14 420-464 7.7e-07 23.3 In-house 252-292 (328) alignment
Range on Protein: 420-464
Range on HMM: 252-292/328.0
MLKFLKKVKACnpqyAGAIVVHCSAGVGRTGTFVVIDAMLDMMHT
. |||. .. .     |||.||| ||.|||||..    | .   |
vkkfleiaeka....eGaiavhCkaGLGrtGtLiacylmkhyrft

subfamily_eak_pd Subfamily eak 421-505 3.5e-10 33.8 In-house 224-308 (332) alignment
Range on Protein: 421-505
Range on HMM: 224-308/332.0
LKFLKKVKACNPQYAGaiVVHCSAGVGRTGTFVVIDAMLDMMHTERK--VDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYG
  .||| .   | .|   .. .. |  |.|.||||| .. ..   .|    |  .. ... .|   | ...|. |||...|.. |  
sstlkkyihtppsfap..iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrr

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 424-500 9e-16 52.6 In-house 218-293 (297) alignment
Range on Protein: 424-500
Range on HMM: 218-293/297.0
LKKVKACNPQYAgAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
|. ..|  |. |  ..|||||||||.|  |  |..|...  .|  ||  ..| .| || ..|||  |. ..|.| |.
leslraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk

PTPc_motif_SM00404 427-487 3.2e-06 22.1 In-house 73-126 (140) alignment
Range on Protein: 427-487
Range on HMM: 73-126/140.0
VKACnPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTerKVDVYGFVsriRAQRcQMVQT
....  .  |...||| ||| |..|...   |  .  .    ..| ||   . .| .... 
iena.ekkggkvlVHCqaGvSRSatliiaYlmryrqls..laeayefv...kerR.piisp

subfamily_CG42327_pd Subfamily CG42327 435-500 9e-16 52.4 In-house 247-313 (319) alignment
Range on Protein: 435-500
Range on HMM: 247-313/319.0
AGAIVVHCSAGVGRTGTFVVIDAMLDMMHTE-RKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
 | .||||| ||||||. .  |  .  . .  | ||.   || .| .|.. |.|  || |||. | |
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse

subfamily_PTEN_pd Subfamily PTEN 437-501 3.3e-06 22.2 In-house 116-181 (184) alignment
Range on Protein: 437-501
Range on HMM: 116-181/184.0
AIVVHCSAGVGRTGTFVVIdAMLDMMHTERKVDVYGFVSRIRAQRCQMVQ--TDMQYVFIYQALLEH
 .|||| || ||||. .|   .| ....|.. ..  . ...|..  . |.    . ||  |..|||.
vvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyekllee

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 438-501 7.6e-15 49.1 In-house 1-64 (69) alignment
Range on Protein: 438-501
Range on HMM: 1-64/69.0
IVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
.|||||.| ||||||. |   .  . .|. ||..  |  .|  |  ||  ...|.||. || | 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 439-501 9.1e-14 45.6 In-house 1-63 (69) alignment
Range on Protein: 439-501
Range on HMM: 1-63/69.0
VVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
|||||.| ||||||. |   .  . .|. ||..  |  .|  |  ||  . .|.||..|| | 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 505-799 9.3e-107 351.7 In-house 1-297 (298) alignment
Range on Protein: 505-799
Range on HMM: 1-297/298.0
GDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIK--IQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDS
|.||.|...|...|||. .. . ..  |...||..|.|..  |...... .. |.| ||||  .||.... ||..  . ..|..||.||||...|.....
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGI
.||.|.|| .|.||||||..| .. .|||||.||| .. |. .|||..|   ||.|||.|...||   ..|| | |....|.|.|..||.||  ||. |.
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA
|.  . .. ... |...|||.||.|..|.|||| ||.|||.|...||||||.|  .||||.|| || .||..||| ||| |.|..|.|..|.|.|..
penatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

0051299 (Phosphotyrosine protein) phosphatases II 506-792 5.5e-105 346.2 In-house 2-286 (288) alignment
Range on Protein: 506-792
Range on HMM: 2-286/288.0
DTELEVTSLETHLQKIYnkipGTSNNGLEEEFKKLTSIKIQnDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIA
|||..|..|. ...|..     ....||.|||..|.|....  ......||.|..|||   |.||. .||.. |  |.|..||.|||.||||..|  .||
dteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIa

SQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNT----RENKSRQIRQFHFHGWPEVG
 |||| .|.||||||.||...  |||||.|.|.|.||||||||..| . ||||||.|..||....|||| | |||.     ...||....||...||. |
tqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhg

IPSDGKGMISIIAAVQKQQQqSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
.|.. . ..... .|.|... ||..|. |||||| ||||||.|| ..||....|| .||...|| || |||.||||.|||.|.|... ||.
vpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_PTPRG_pd Subfamily PTPRG 514-794 8.7e-87 286.6 In-house 6-289 (563) alignment
Range on Protein: 514-794
Range on HMM: 6-289/563.0
LETHLQKIYNkipgTSNNGLEEEFKKLTSIKIQN-DKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENT-DYVNASFIDGYRQKDSYIASQGPLL
.. |. ...      .. |..|||..|.|  |..  .. . . | | .||| |.|..|.  || .    |.... ||.||..||||.... .||.|||| 
fakhvaslha....dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

HTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRE------NKSRQIRQFHFHGWPEVGIPSD
.|..|||||||| ..  |||.|.|.|||..|| .|||.|. . || ..| |..||   .|||| | . |..       .. ...||.|.  ||..| |. 
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

GKGMISIIAAVQKqQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA
    .. .   ..  ...   ||.||||||.|||||...|.|.|.....| . .||...| .|.||...||| ||| | .....| | .
slpvLifvkkssa.ankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias

0039614 (Phosphotyrosine protein) phosphatases II 516-795 4.8e-96 316.9 In-house 17-292 (297) alignment
Range on Protein: 516-795
Range on HMM: 17-292/297.0
THLQKIYNKIPGTSNNGLEEEFKKLTSIKIqnDkMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGE-ENTDYVNASFIDGYRQ-KDSYIASQGPLLHT
..|  .. ... .|...|..||..| |.|.  | .....||.|..|||   |.||...||.. ...|  ...||.|||..|||.. .. .||.|||| .|
svldlllllekansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

IEDFWRMIWEWKSCSIVMLTELEERGQeKCAQYWPSDGLvSYGDITVELKKEEECESYTVRDLLVTNtrENKSRQIRQFHFHGWPEVGIPSDGKGMISII
.||||||.||... .|||||.|.|.|. |||||||..|   |||.||.|.|.|... |||| | |||  ...||....|...|||. |.|.. . .....
vedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefl

AAVQKQQQQS-GNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF
 .|....... ...|. |||||| ||||||.|. ..||... || .||...|| || |||..|||..||.|.|....|..  .
elvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

subfamily_PTPN6_pd Subfamily PTPN6 516-794 3.8e-78 257.6 In-house 11-299 (306) alignment
Range on Protein: 516-794
Range on HMM: 11-299/306.0
THLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKM-RTGNLPANMKKNRVLQIIPYEFNRVIIPvKRGEENTDYVNASFIDGY--RQKDSYIASQGPLLH
 . ... ..   ....|.||||..|   . ..    . |. | |..|||   |.|.. .|||.  . .  ..||.||..|..    .. ||||.|| | .
qrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclet

TIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGL-VSYGDITVELKKEEECESYTVRDLLVT-NTRENKSRQIRQFHFHGWPEVGIPSDGKGMI
|..|||||.|. .|  |||.|.  |||.||||.|||.     .||.|.|.  .|.. ..|..|.|.|. .......|...|.||. ||. |.|.| . ..
tvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavL

SIIAAVQKQQQQSG---NHPITVHCSAGAGRTGTFCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA
. .  |...|...    . || |||||| ||||||  . ..|. .. .|.   .|. ..|||.| ||  .||| .|| | ||....||..
dfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet

0043336 (Phosphotyrosine protein) phosphatases II 517-792 1.7e-98 324.7 In-house 6-277 (278) alignment
Range on Protein: 517-792
Range on HMM: 6-277/278.0
HLQKIYNKIPGTSNNGLEEEFKKLTSIKIqnDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIED
.|.| ....  ... .|..||..|.|.|.  | .....||.|..|||   |.||...||.. .  |....||.|||..|||.... .||.|||| .|.||
dllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved

FWRMIWEWKSCSIVMLTELEERGQEKCAQYWPsDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV
||||.||... .|||||||.|.|..||||||| .| . |||.||.|.|||... ||||.| |||.....||.....|..|||. |.|.. . ..... ||
FwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

QKQQQqSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
..... . |.|. |||||| ||||||.|| ..||... || .|....|| || |||..|||..||.|.|....||.
reale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl

0045450 (Phosphotyrosine protein) phosphatases II 517-792 4.6e-95 314.1 In-house 13-304 (307) alignment
Range on Protein: 517-792
Range on HMM: 13-304/307.0
HLQKIYNKIPGTSNNGLEEEFKKLTSIKIQ-NDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGE-ENTDYVNASFI--------DGYRQKDSYIAS
.| ..... . ....||..||.|| |.... ........||.|..|||   |.||. .||.. .  |. |..||.|||..        |||..|. .|| 
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLV-SYGDITVELKKEEECESYTVRDLLVTNT-RENKSRQIRQFHFHGWPEVGIPS
|||| .|.||||||.||...  |||||||.|.|.||||||||..| .  ||..||.|..||....|||| | ||..  ...||....||..|||. |.|.
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp

DGKGMISIIAAVQKQQQQS-GNHPITVHCSAGAGRTGTFCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
. . ....| .|.| .... ...|. |||||| ||||||.|. ..|.....||.   .|....|| || |||..||..|||.|.|....|..
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

subfamily_PTPRB_pd Subfamily PTPRB 517-793 6.3e-89 292.9 In-house 11-286 (293) alignment
Range on Protein: 517-793
Range on HMM: 11-286/293.0
HLQKIYNKIPGTSNNGLEEEFKKLTSIKIQnDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIED
.... ..|.   |. .. ||...| ... .  .. . .|..| .|||  .|.||. .|| .   ..|...||.||..|.||...  .||.|||| .|..|
kfeehvkkmkadsdlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvdd

FWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD-GLVSYGDITVELKKEEECESYTVRDLLVTNtrENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAA
||||.|| ||  |||||.| |.|..|| .|||.|   | ||||.|.|..||| | ...|.|....  |...|..||.||  ||. |.|.. | ..... .
fWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrt

VQKQQ-QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
|.... ... ..||.|||||| |||||| || ..|.... | ..|.| .| .|| .| ..||| .|| | ...|.... 
vreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr

subfamily_PTPN9_pd Subfamily PTPN9 518-792 5.4e-84 276.7 In-house 3-290 (297) alignment
Range on Protein: 518-792
Range on HMM: 3-290/297.0
LQKIYNKIPGTSNNGLEEEFKKLTSIKIQnDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDF
.... . .  . ..|| .|.... . ...  .. . .|.||..|||   .. |.  || .. . ..|..||.||.|.|||.||...|| |||| .|..||
ieelvayvkekgkrGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMIWEWKSCSIVMLTELEERGQEKCAQYWP--SDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAA
|||.|| .   ||| | ..|||. ||.||||  ..   ..||..|.  . || | |.|| | ..|.....||..  | | .||. |.||... .. .. .
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

VQKQQQQS------------GNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
|...| ..             . || |||||| ||||||..|   |.|.. .| .||..||| || || ...|| |||||||. | || 
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

0050432 (Phosphotyrosine protein) phosphatases II 520-799 6.2e-105 346.2 In-house 34-306 (308) alignment
Range on Protein: 520-799
Range on HMM: 34-306/308.0
KIYNkipGTSNNGLEEEFKKLTSIKIqNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIpvkrgEENTDYVNASFIDGY--RQKDSYIASQGPLLHTIEDF
....    ... .|||||..|.|.|. . ......||.|..|||   |.||. .||..     .|..||.|||..|||  ...  .|| |||| .|.|||
llek...aldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedF

WRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD---GLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIA
|||.||...  |||||.|.|.|.||||||||..   | . ||..||.|..||....|||| | .||.....||....||...||. |.|.. . ..... 
wrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfle

AVQKQQqqsGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA
.|.|..   ...|| |||||| ||||||.|| ..||....|| .|||..|| || |||.||||.|||.|.|....||.  .  ..
lvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkl

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 520-796 4.2e-101 333.2 In-house 12-287 (319) alignment
Range on Protein: 520-796
Range on HMM: 12-287/319.0
KIYNKIPGTSNNGLEEEFKKLTSIkiQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWR
. ....  |....||.|||.|     .||.... . . | ||||  .|..|.  ||...   | |..||.||||||||.... .|| |.|| .|||||||
erlkalastgetllekefkllkea..vndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWr

MIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTREN-KSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK
|.|| .|  .||||.| |... |. .|||.   ..|| ..|.|..||| | | .|.| . .  .. ..|.. .|..  ||. ..| ...... ..  ..|
mvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirk

QQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFS
 .... . ||.||||||.||||||..|. .||||| ||.||||.||. ||.||. |||. |||.|.|... |...|..
srektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 520-788 1.4e-32 107.5 In-house 13-286 (310) alignment
Range on Protein: 520-788
Range on HMM: 13-286/310.0
KIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRT-GNLPANMKKNRVLQIIPYEFNRVIIPVKRGEeNTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFW
 . | |  | . |.|   |.   .  ..|   |      .|.|||  ...  .  || . . .     ||. | ..     ....| ||||| ||| |||
alenfiiateklgieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfw

RMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLV-SYGDITVElKKEEECESYTVRDLLVTNTREN----------KSRQIRQFHFHGWPEVGIPSDgK
|||.. .. ||..|    | |. ||  |||| |.  .|| | |  .  |  | . . .| ||   .|          |  ..   ..  ||. |.| . |
rmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde.k

gmisIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVV
      .  |.   |    |  |||||| .|... .||   .....    .|. . .  |. .|   .||  || .  .| 
....chtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 522-801 1.7e-82 271.6 In-house 11-287 (287) alignment
Range on Protein: 522-801
Range on HMM: 11-287/287.0
YNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPvkrgEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMI
 .| . ..|.| .. |. | ... ..|..  .  . | .|||. ||.... .||..     .|. ||.||.|||||..|  .|....|. .|. .||..|
vakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkli

WEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTR-ENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQ
.. .   ||||....|  .|.| ||||..  |..|. ..|| .||  ..|..|.| |.|.  ... .|..|...  |.. |  .. . .. .|    |.|
ddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq

QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANF
...|| .| ||||.. ||...|||  | ....| ||..|||| .|| | |.|..||| |||.| ...|.||.|.|. |..|
rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 523-793 6.3e-88 289.5 In-house 13-280 (288) alignment
Range on Protein: 523-793
Range on HMM: 13-280/288.0
NKIPGTSNNGLEEEFKKLTSIKiQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIW
.|   ....|..||...|.... ....  .|.|. | ||||  .|.||...|| .     |...||.|||.|||...|  |||.|||| .|..|||....
akksarnrtgfseeynsLaale.ktksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvy

EWKSCSIVMLTELEERGQEKCAQYWPSDGL-VSYGDITVELKKEEECESYTVRDLLVTntRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ
| |.  ||||||| |.|..|| .|||...  . ||..||.|....| |....| ||.   .... ..| |... .||. |.| . . .. ..  |. ..|
enktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanq

QSgNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
.    ||.|||||| |||||| || .....|..|  .||. ||. || ||. .||||.||||.|.|. . |.
ad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslie

0036941 (Phosphotyrosine protein) phosphatases II 524-792 6.1e-98 323.0 In-house 6-277 (297) alignment
Range on Protein: 524-792
Range on HMM: 6-277/297.0
KIPGTSNNGLEEEFKKLTSIKIqNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIpvkrGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWE
... .....|..||..|..... . ......||.|..|||   |.||...||..    ..|..||.|||..|||..|  .|| |||| .|.||||||.||
lekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

WKSCSIVMLTELEERGQEKCAQYWPSD--GLVSYGDITVELKKEEE--CESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQ
... .|||||||.|.| ||||||||..  . . |||.||.|...|.  ...||.| | ||.|....||....||..|||. |.|.. . ....| .|.|.
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

QQQS-GNHPITVHCSAGAGRTGTFCALSTVLERVK---AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
.... ...|. |||||| ||.|||.|. ..|....    || .|....||.|| |||..|||||||.|.| ...|..
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell

subfamily_Ptp69D_pd Subfamily Ptp69D 524-793 2.8e-88 291.0 In-house 15-287 (307) alignment
Range on Protein: 524-793
Range on HMM: 15-287/307.0
KIPGTSNNGLEEEFKKLTSIKIQNDkMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWE
.  . .. ||..|..|| . .|. .  ....   |  |||  .|.... .||....  |.|..||.||||| ||..| ..||.|.|.  ||.||||||.|
srkrdtdfglakeyekLeareidks.tkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiae

WKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTR-----ENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK
 ..  ||||..|.|  ..|||.||| .  | |||| |.| .||... |. |.| |...      ...||.. |.|. ||... .|   .|.. .|  |..
qevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvre

QQQQSgNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
 .... . ||.||||||.||.|.| ||. .|...|||  .|.|.||| || ||. .|| ||||.|.|. . .|..
lykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 527-794 2.5e-81 267.9 In-house 11-278 (281) alignment
Range on Protein: 527-794
Range on HMM: 11-278/281.0
GTSNNGLEEEFKKLTSIKIQNDKmRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKS
  .|.|. ||..||..| ..|   .  . ..|..|||   |. |.  || .  .  ..||||.||.|..||...  |||.|||. .....||.|.|| | 
qndnaGfieeyeklaaigvdnta.taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkv

CSIVMLTELEERGQEKCAQYWPSDG-LVSYGDITVELKKEEECESYTVRDLLVtNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGN
. |||.|.  | |. || .||| |   ..|||.||. ..||| ..|  | . . .......|...|...  ||. |.|.. | ...  ..|.| .... .
saivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk

HPITVHCSAGAGRTGTFCALSTVLERVKAE-GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA
.|. .||||| |||||. || .....|.||   ||| ..|..|| .|  ||||. |||| ||.| ...| 
aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk

0047943 (Phosphotyrosine protein) phosphatases II 528-792 2.1e-98 324.4 In-house 9-272 (273) alignment
Range on Protein: 528-792
Range on HMM: 9-272/273.0
TSNNGLEEEFKKLTSIKIqNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIpvkrGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSC
.....|.|||..|.|.|. . ......||.|..|||   |.||. .||..    |....||.|||..|||..|  .|| |||| .|.||||||.||... 
lgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

SIVMLTELEERGQEKCAQYWPSDG---LVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQS-
 |||||||.|.|.||||||||..|    . ||..||.|..||....|||| | .||.  ..||....||..|||. |.|.. . ....| .|.|..... 
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

GNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
.|.|. |||||| ||||||.|| ..|.....|| .||...|| || |||.||||.|||.|.|... ||.
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 528-795 4.1e-91 300.3 In-house 19-286 (305) alignment
Range on Protein: 528-795
Range on HMM: 19-286/305.0
TSNNGLEEEFKKLTSIkiqNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSC
.|..|||...|.|..    ....  |.  || .|||. .|......|.|.  |  ....||.|||..|||..|..||..|||| .|..||||.|.| |  
ysdkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvs

SIVMLTELEERGQEKCAQYWPSDGLV--SYGDITVELKKEEECESYTVRDLLVTN-TRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG
.|||||.| | |..|| ||||        .|...|||| |.. . |. |.| ...   ...||.. |...  ||. |.|     ..|.|  |||.|... 
tivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk

NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF
. |..|||||| ||||.|.|..  |||.|.|...|||. .| || .|. |||||.|| |.. ...|.| ..
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 528-798 1.7e-81 268.3 In-house 17-289 (290) alignment
Range on Protein: 528-798
Range on HMM: 17-289/290.0
TSNNGLEEEFKKLTSiKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEEN--TDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWK
. |.| ...||.| |   .. .. .|. . | ..||  .|..|. ||...  . |...   .|.||..|.||..| .||| |||. .|. |||..||. |
kgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqek

SCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRE-NKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG
.. |||||.  | |..|| ||||. .  .|| ....| .||....|. | | |.|... ...... |...  |.. |   . ......|. ..|.| ..|
vtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg

NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDY
|..| ||||.. ||...|||. | ....| ||  |||| .||.| |.| .||| .||.. ...| .|.| |. |
ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 528-800 6.2e-69 227.0 In-house 12-301 (301) alignment
Range on Protein: 528-800
Range on HMM: 12-301/301.0
TSNNGLEEEFKKLTSIKiqNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRG--EENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWK
. .|..||..|.|.. .  ....  |   .| . ||  .| .|. ||.|.  |.     ...|.|||.||||..|  .||.|||. .|. ||||.||. |
khsnkfeeqykelkege..dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

SCSIVMLTELEERGQEKCAQYWPSDGL--VSYGDITVELKKEEECESYTVRDLLVT-----N----------TRENKSRQIRQFHFHGWPEVGIPSDGKG
  ||||.|.|.|. ..|| ||||.      ..| .||.|..|    ....|.| |.     |          .....|... |..   ||. |.  . . 
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

MISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYAN
.. .|  | ..||. |  |. ||||.. .|.|..|..|  || .||||. |||| .|..| ..| .|.||||| . |.|...|.   | |||
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 528-792 2.5e-57 189.3 In-house 17-279 (439) alignment
Range on Protein: 528-792
Range on HMM: 17-279/439.0
TSNNGLEEEFKKLTSIKIQNDKMRT-GNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKS
  .. ..|.|.|. |.. .   . .      .  |||  .. .... ||..    |   . |.|| .|.|| ... |||.|||  .| .||||...| |.
nkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekkt

CSIVMLTELEERGQekcaqYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRE--NKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG
  |||||.| |  .     |||||. | ||||.|   .. |   |..| . | | |.  .| | . |||.  ||.  .|..   ..  . |..  ...  
vtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkee

NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
  |. |||||| |||||  ||   ||..|.|  .|.   || || || .|||.| || | |. | | |
ygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 528-608 4e-15 49.8 In-house 20-95 (95) alignment
Range on Protein: 528-608
Range on HMM: 20-95/95.0
TSNNGLEEEFKKLTSIkiQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRgeeNTDYVNASFIDGYRQKDSYIASQG
 |.. ...||| ..          .|   ||. |||.|.|.||.  ||..  ||   ..||.|| |.||| .|. |||.||
nsdqefdnefksismt..sgapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg

0040438 (Phosphotyrosine protein) phosphatases II 529-792 2.3e-99 327.9 In-house 16-276 (317) alignment
Range on Protein: 529-792
Range on HMM: 16-276/317.0
SNNGLEEEFKKLTSIKIQndKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCS
....|.|||..| |.|.    .....||.|..|||   |.||...||.. .  | ...||.|||..||...|. .|| |||| .|.||||||.||.....
dftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

IVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQqSGNHPI
|||||||||.|.||||||||... . |||.||.|..|||....|.| | |.......||....||..|||. |.|.. . ..... ||..... ....|.
ivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpv

TVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
 |||||| ||||||.|. ..||... || .||...|| || |||..|||.|||.|.|....||.
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 529-790 8.2e-77 253.2 In-house 22-277 (315) alignment
Range on Protein: 529-790
Range on HMM: 22-277/315.0
SNNGLEEEFKKLTSIkiQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCS
..||...... .     |   ... .   | .|||  .||.|.  || .|.   ....|||||.||||| .|. |||.|||.  ...||||...| .   
tkngfkqdyesipgg..qlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigk

IVMLTELEERGQEKCAQYWPSDgLVSYGDITVELKKEEECESYTVRDLlvTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGnHPI
|||||.| |. ..|. .||| .  | || ||| .|.||  . |||| |  . . ... |.. |.|.  ||..|.|     .. .|  |.. ...|   .|
ivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gai

TVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE
 |||||| ||||||..|..||....|| ..||.. .. .| .| .|||..|||.| |... |
vvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 529-790 5.4e-68 223.9 In-house 4-264 (283) alignment
Range on Protein: 529-790
Range on HMM: 4-264/283.0
SNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPvkrgEENTDYVNASFID---GYRQKDSYIASQGPLLHTIEDFWRMIWEWK
..|. .  ...|  . . . .        | .|||  .|.|.. .|| .      |. ||.||.||     |.|.  ||..|.|| .|. |||.|... |
rvnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelk....sesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdek

SCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSR-QIRQFHFHGWPEVGIPSDGKGMISiIAAVQKQQQQSG
 ..|||||.| |  ..||.||||..| . ||. || |.||   .|.... ||. .    ||   .  . . .| |.|  .    ..  .  |. .|..| 
itaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvk.fnkvislqtesk

NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE
. || ||||.| |||..|.|.|. .. ...| ..|||..|| .| ||. .||||.|| . ...| |
kgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 529-792 1.1e-31 104.8 In-house 20-287 (305) alignment
Range on Protein: 529-792
Range on HMM: 20-287/305.0
SNNGLEEEFKKLTSIKiQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIpvkRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCS
. .|| .||. .  .. . .||..     . .|||  ..   . ||| .   .|    .|. | ..    .   .| .| || .|  ||| | .. |  .
gpaglraefvamkrfn.dfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkvea

IVMLTELEERGQEKCAQYWPSDG--LVSYG--D--ITV------ELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIaav
| || .| |.| .||..|..|.    ...   .  |.|      .|| ......   .  || .   .|.|.. ..|.  ||. |.|.    .. ..   
ifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailell...

QKQQQQSGnhPITVHCSAGAGRTGTFCALSTVLERVKAEGILD-VFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
.| .   |  ||.|||||| ||||.   |  .|... |  |..   . .. .| ||   .|| .|| | ..|. .|.
ekarpskg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf

subfamily_PTPN12_pd Subfamily PTPN12 530-793 1.3e-79 262.1 In-house 7-278 (290) alignment
Range on Protein: 530-793
Range on HMM: 7-278/290.0
NNGLEEEFKKLTS--IKIQNDK---MRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEW
.. ...||.|| .   | ...|     .|. . |.||||   |.||...|| .  ...||. ||.||.|| |  .| .|||.|||| .|..|||||||| 
eeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwek

KSCSIVMLTELEERGQEKCAQYWPSDG--LVSYGDITVELKKEEECE-SYTVRDLLVTNTreNKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ
.   .||. .. | |. ||..|||. |   . .|...|.|..|. ..  ...| | |..   ..||...|||.. ||. |.||  | ....|..|.. |.
nveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe

qSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
 | ..|. |||||| ||||| .|.  | | .||| |   ||||. | .|| ||. .||| ||||. || | |.. 
.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq

subfamily_PTPN23_pd Subfamily PTPN23 530-793 8e-67 220.1 In-house 14-281 (288) alignment
Range on Protein: 530-793
Range on HMM: 14-281/288.0
NNGLEEEFKKLTSIKIQNDK-MRTGNLPANMKKNRVLQIIPYEFNRVIIPvkrgEENTDYVNASFIDGYRQ-KDSYIASQGPLLHTIEDFWRMIWEWKSC
. .|...||.|.. . .. . . .     . .|||   |.||. ||| .     ... ||.||||. .      ..||.|.||  |. |||.|..| || 
ktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkss

SIVMLTELEERGQEKCAQYWPSD--GLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK---QQQQ
 ||||.. ||.|..|...|||.|    |..||..| ||...| | .  |.| ..  .... ....  ... |||.|.|.  . .. .. .|..   ..|.
viVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqr

SGNHPITVHCSAGAGRTGTFCALSTVLERVK-AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
  . |. |||||| ||||.|. . .... ..  .|.||. | |. || || .|||. ||..|.|..| |.. 
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar

subfamily_PTPRN_pd Subfamily PTPRN 530-794 1.2e-64 212.9 In-house 28-294 (297) alignment
Range on Protein: 530-794
Range on HMM: 28-294/297.0
NNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFI-DGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCS
.. ||.|.. |.. . ..    ... . |.||||. ...||. .|| .  .  .|..||.|||.| |   .. .|||.|||| .|. |||.|.||  .. 
kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvv

IVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEE-ECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQsGNHP
||.||.||| | ..|..||| .|   |.   |.|  |   |. | || . . | . ...| . ||||  ||| |.|.  | ..     |.|  .     |
ivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscp

ITVHCSAGAGRTGTFCALSTVLERVK-AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA
| ||||.||||||.....  ||.|..     .|.  |.. || |||..|.| .|.||....| | ..|
ivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevna

0049772 (Phosphotyrosine protein) phosphatases II 530-795 2.9e-47 157.3 In-house 18-283 (314) alignment
Range on Protein: 530-795
Range on HMM: 18-283/314.0
NNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEfNRVIIPvKRGEENTDYVNASFIDGYrqkDSYIASQGPLLHTIEDF----------WR
 ..|. ... .. . ...  . ...|..|..||| |.|.|.. ||||.| . . ...|| |||..||.    ..||.|||| .|..||          ||
llklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilp.glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwr

MI--WEWKSCSIVM---------------------LTELEERGqekcaQYWPSDGLVSYGditvelkkeeecesytvrdlLVTNTRENKSRQIRQFHFHG
|.  .....  |||                     |..| ..|      ...   |  .                      ... .|  .|.. ... . 
mvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk....................eelydpelferlgikylrip

WPEvGIPSDGKGMISIIAAVQKQqqqSGNHPITVHCSAGAGRTGTFCALSTVLERVkaeGIlDVFQTVKSLRLQRP-----HMVQTLEQYEFCYKVVQEY
.|  | . . . . ........    . ..|. |||.|| ||||||...  .. .    |. .. .... .||.||     .....||||||......||
vpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealley

IDAF
.. .
lkfl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 530-792 4.9e-28 92.4 In-house 25-285 (302) alignment
Range on Protein: 530-792
Range on HMM: 25-285/302.0
NNGLEEEFKKLTSIKIQNDKmrTGNLPANMKKNRVLQIIPYEFNRViipvKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTI---EDFWRMIWEWKS
.  ...||||. ..|.. .|       .|.|||.  ..  .. |.|    | ..|. .||||| ..    . | | .| | . .    |.||||... | 
taevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlv....kleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqeki

CSIVMLTELEERGQeKCAQYWP--SDGLVSYGDITVELKKEEECESYTvR----DLLVTNTREnkSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVqKQQ
 |.|.|   ||  .    ...|  |.  . ||.. |  .| |. |  .      ..|  .  .  |  .   ... |..  .|     .|  .| |  ..
vsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsn..svlanvyvltnWkqkkvpvkyaeliktaakv.fak

QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
........ .    |||| |.| .| ...|.....    . ..|||.| |||..|..|.|| . | ..  ||
kikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 531-793 1.8e-50 166.4 In-house 6-260 (267) alignment
Range on Protein: 531-793
Range on HMM: 6-260/267.0
NGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEentdYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIV
  .|.||.... |  .. .. .     | ..||. . .||. .|||.  |  |    |.|||...||..|  .|. |.||  || ||. .| . |   ||
ceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpviv

MLTEleeRGQEKCAQYWPSD--GLVSYGDITVELKKEEECESYTVRDLLVTnTRENKSRQIRQFHFHGWpevGIPSDGKGMI-SIIAAVQKQQQQSGNHP
.||     ....  ..||        | |.|||   |.| . | .  | .   ... ....  .... |    | .. |  .  ... . |.| . ||.|
lltk...vftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelk.fknesahnvtlyyykkw...nintnnkpylkplfgilaknqlengnrP

ITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
. |.||.| ||.|||  . . |||.| ||..|.|. .. .| ||. .|.|.|.| ...... || .
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 532-800 2.2e-108 357.1 In-house 21-288 (318) alignment
Range on Protein: 532-800
Range on HMM: 21-288/318.0
GLEEEFKKLTSIKIQNDKMRTgNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVM
 |.||...|.  . .  .... . |.| .|||   |..|.  || .  . |||..||.||..|||||.| .|||.|.|| .||||||||.|| .|. |||
llseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivm

LTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVH
||..||||..|...||||.|  |||...||||.| |...|..| . ||.| |..|||.||.|.  ||. |.|..| ......  |.| ||.||..||.||
ltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvh

CSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYAN
|||| ||||.|.|....|||.|||...||||||| || ||. |||| .||||.|.|..|.. ..  ...
CsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd

0046845 (Phosphotyrosine protein) phosphatases II 532-799 1.4e-100 331.6 In-house 1-281 (284) alignment
Range on Protein: 532-799
Range on HMM: 1-281/284.0
GLEEEFKKLTSIKIQND-KMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGE-ENTDYVNASFIDGY-----RQKDSYIASQGPLLHTIEDFWRMIWEW
||||||..|.|...    ......||.|..|||  .|.||. .||.. .  |. |..||.|||..|||     ..|  .|| |||| .|.||||||.||.
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KSCSIVMLTELEERGQEKCAQYWPSDG-LVSYGDITVELKKEEECESYTVRDLLVTNTR-ENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQ
..  |||||||.|.|.||||||||..|  . |||.||.|..||....|||| | .||.  ...||....||...||. |.|.. . ..... .|......
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-SGNHPITVHCSAGAGRTGTFCALSTVLERVKAEG---ILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA
 .|..|| |||||| ||||||.|| ..||....||    .||...|| || |||.||||||||.|.|....||.  .  ..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 532-799 1.5e-89 295.5 In-house 35-299 (319) alignment
Range on Protein: 532-799
Range on HMM: 35-299/319.0
GLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVM
 || ||.... . ..  ..   ||. |  |||. .|.... |.| .    ||| .||.||||..||..|| |||.||||  |..||||||||.....||.
klevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivl

LTeleergQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTN-TRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK-QQQQSGNHPIT
||      ..||.|||| .. . ..   |...  ||.. |.|||. ... ..|.  |.|.|||| |||.|| |  .  .. ..  |.. .... ....| 
lt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhraniv

VHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE-YIDAFSDYA
||||||.||||.. .| ..|.|.| |  .||...|. || ||...|| | || |.|  . | .. ..|| |
vhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 532-792 1e-69 230.2 In-house 24-288 (325) alignment
Range on Protein: 532-792
Range on HMM: 24-288/325.0
GLEEEFKKLTSIKIQNdkMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKsCSIVM
|.  ||. | |   .   ...  .|.|..|||   ..... .||..  |. . ..||.|||..  ...|| ..|.| || .||.|.||.. .|. ||.|.
gfahefgllpsddgia..kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvv

LTELEERGQEKCAQYWPSD--GLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ-----QSG
...  . |...||.||| .    . .| . |.|.  ||   |  | | | .... ..| ..||.. .|...| .     .|||.  |.. ..       .
vlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantka

NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
  || |||||| ||||.| .| ..|..|  |  .|.|. || || .|| ||.| .|| ..|. . |..
stpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 532-792 1e-37 124.8 In-house 17-277 (307) alignment
Range on Protein: 532-792
Range on HMM: 17-277/307.0
GLEEEFKKLTsiKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKrgEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVM
 | .||..|.  | . . . .  . || .|||  ..   . .|... ..     .||. | ..    .   .|..||||  |. .|| |. . |  |..|
alvdefrvla..kktpegvtveafsantdknryqdvkcqdkgrivvkfd..glasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvim

LTELEERGQEKCAQYWPSD-G-LVSYGD----ITVE------LKKEEECesYTVRDLLVtnTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQ
| .. | .. || |||| . |    .|.    |.|.      |  .|..    | .| |     .||| |... .. ||. |.|    . | .. ||. .
lckvielakikceqywpleegqklvfgeapntisvanlgakklapdedl..invttlkv..dwaqksrtiqhlqwenwpdrgvpqinltainlleavryd

QqqsgnHPITVHCSAGAGRTGTFCALSTVLERV-KAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
.      |. |||||| ||.||  |.| | ... . .   |. . |. || ||.. .||  || . ..|. || 
t.....npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf

DSPc_SM00195 533-792 2.6e-93 307.5 In-house 2-262 (263) alignment
Range on Protein: 533-792
Range on HMM: 2-262/263.0
LEEEFKKLTSIKIQNdKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVML
|.|||.|| . . .. ...... ..|..|||  .|.||. .||... . ..|..||.||..|.|...| .||| |||| .|.||||||.|| |.  ||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TELEERGQEKCAQYWPSD--GLVSYGDITVELKKEEECE-SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSgNHPIT
|| ||.|.|||..|||..  |   .|.|.|.|...|... ....|.| .|.. ....|...|.....||. |.|.. | ..... ||.|....| ..|| 
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
|||||| ||||||......|.....|  .|.|..||.|| |||.|||||||| |.|... |||
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 533-792 2.6e-93 307.5 In-house 2-262 (263) alignment
Range on Protein: 533-792
Range on HMM: 2-262/263.0
LEEEFKKLTSIKIQNdKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVML
|.|||.|| . . .. ...... ..|..|||  .|.||. .||... . ..|..||.||..|.|...| .||| |||| .|.||||||.|| |.  ||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TELEERGQEKCAQYWPSD--GLVSYGDITVELKKEEECE-SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSgNHPIT
|| ||.|.|||..|||..  |   .|.|.|.|...|... ....|.| .|.. ....|...|.....||. |.|.. | ..... ||.|....| ..|| 
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
|||||| ||||||......|.....|  .|.|..||.|| |||.|||||||| |.|... |||
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 533-793 5.9e-70 230.5 In-house 7-269 (274) alignment
Range on Protein: 533-793
Range on HMM: 7-269/274.0
LEEEFKKLTSIKiqndKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEEN-TDYVNASFIDGYRQK-DSYIASQGPLLHTIEDFWRMIWEWKSCSIV
||.|| .| .      ...  ... . .|||  .|.| |  ||..  . .|.. ..|.|| .| ||...   |.| |||| .|..||||||.. ..  ||
lekeflelPlnf....dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MLTELEERGQEKCAQYWPSDGLV----SYGDITVELKKEEECESYTVRDLLVTNTREnkSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNH
|||.|.|. ..|||.|.| .  .     |||. .. .|  |.. |.|| |.. .. .  .|..  . .  ||.   | | . ...... |....... ..
mltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenak

--PITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
  |. |||||| |||| | | |  . ....|...||...|  |||.|  |||| ||||. .... .|  
lapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk

subfamily_CG42327_pd Subfamily CG42327 533-717 1.1e-39 131.0 In-house 7-191 (319) alignment
Range on Protein: 533-717
Range on HMM: 7-191/319.0
LEEEFKKLTSIKIQNDkmrtgNLPA-NMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQK-DSYIASQGPLLHTIEDFWRMIWEWKSCSIV
. |||..|  .  . |     ..|.   .|.||....|    ||. . .  .... |..||.. ||..   ||||.| .|  .  ||||..|| .|  ||
vaeefrdlPqliarad.....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrviv

MLTELEERGQEKCAQYWPS----DGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFhGWPEVGIPSDGKGMISIIAAVQ
 ||.| | | ..||.|.|.    |.  .|||| | ||. |  . | .  ||. .  ...||..  . .  |.| ..|.. . .|...  |.
qltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr

subfamily_ptpA1_pd Subfamily ptpA1 533-750 5.3e-36 119.2 In-house 23-254 (418) alignment
Range on Protein: 533-750
Range on HMM: 23-254/418.0
LEEEFKKLTSiKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDsYIASQGPLLHTIEDFWRMIWEWKSCSIVML
..|||. |    .   .   |.   |  |||  .|.| .. || .   . .| .||.|| .|||   |. .|..||||  || |||||.|| .   ||||
ikeefrllee.svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivml

TELEERGQEKCAQYWPSD-----------GLVSYGDITVELKKEEEcesYTVRDLLV---TNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK
.   |  . || .||| .           |   .|  .||| .  .      |...      | | ..|.| |... |||.  ||   . .  .. .. .
sresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviq...dpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitn

QQQQ-----SGNHPITVHCSAGAGRTGTFCALSTVLE
.|.|       | || |||||| |||||||.   ...
rqnqiipssdrnvpiivhcsagvgrtgtfctavimmk

subfamily_PTPN13_pd Subfamily PTPN13 534-791 1.8e-66 219.3 In-house 14-268 (273) alignment
Range on Protein: 534-791
Range on HMM: 14-268/273.0
EEEFKKLTSIKIQnDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGeentdYVNASFIDGYRQKDS--YIASQGPLLHTIEDFWRMIWEWKSCSIVM
.||||.|  .| . |. ..|.  .|..|||  ...||.  ||..  . |     |.|||.|    .||   |||.|||| .|..|||.|.|| |.  |.|
aeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

LTELEERGQEKCAQYWPSD---GLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQqsGNHPI
.|   |.|. || .|||.     |. .. ..||| | .. ....||.| |.... ..||.. ...|  ||. |.||  . .. ..| |.. |.   . ||
vtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPi

TVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY
 |||||| ||.||. .. .||. .. .  .|| ..|..|| ||  .||| .|| |.||.. | 
vvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 534-789 6.2e-51 168.0 In-house 23-233 (392) alignment
Range on Protein: 534-789
Range on HMM: 23-233/392.0
EEEFKKLTSIKIQNDkmRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLT
 |||. | . .| ..  .... . |.||||  .|.||. .||.. |     ..||.|||.|... .. .|||||||   ...|||||... . ..|.|.|
feefhdlpgpdiypq..tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvt

ELEERGqekcaqywpsdglvsygditvelkkeeecesytvrdllvtntRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQsGNHPITVHCS
.|.|                                            . .. | . ||||  ||. ..|     .. .|  |. .  |   ||. .|||
klkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGq.ythpliihcs

AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQ
|| ||||   .. .|. . |   ..|||. |  .| .||.|||| ||| | |  | 
agvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl

subfamily_PTPRA_pd Subfamily PTPRA 535-792 6.5e-138 454.1 In-house 36-302 (330) alignment
Range on Protein: 535-792
Range on HMM: 36-302/330.0
EEFKKLTSIKIQNdKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTE
|||. | . .||.  . . .   |..||||..|.||.|.|||..||.|.|..||.||||||||..||..||.|||. .|.|||||||||.||..||||||
eefnalPagpiqa.tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlte

LEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVT----NTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNhPITV
|.|| .||||||||..|||.||.|.||...|.....||||..||.    .|||.|||..|||||..||.||.|....||......|.|..|||.. ||.|
lkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivv

HCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY-------I
|||||.||||||..|..||||||||...|||..||.||||||.||||.|||||.|||..||       .
hcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdtel

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 535-799 8.7e-88 289.5 In-house 2-263 (284) alignment
Range on Protein: 535-799
Range on HMM: 2-263/284.0
EEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTe
 ||.... . ..  ..   ||. |  |||. .|.... |.| .    ||| .||.||||| ||..|| |||.||||  |..|||||||| ....||.|| 
vefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.

leergQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTN-TRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK-QQQQSGNHPITVHC
     ..||.|||| .. . ..   |...  ||.| |.|||. ... ..|.. |.|||||| |||.|| |  .  .. ..  |.. .... ....| |||
.....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

SAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE-YIDAFSDYA
|||.||||.. .| ..|.|.| |  .||...|. || ||...|| | || |.|  . | .. ..|| |
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 535-792 3.9e-74 244.3 In-house 23-277 (315) alignment
Range on Protein: 535-792
Range on HMM: 23-277/315.0
EEFKKLTSIKIQndKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTE
|||. |   .|   . |..  . |.||||   |.|.. .||.. |   . . ||.|||.| .. .  .||||||||  ...|||||... |  .|||.|.
eefhdlpdPdiy..rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtk

LEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTVRDLlVTnTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQqQQSGNHPITVHC
..|  . ||.||||     .| .| | ||| . | .   ..| | ||  . ..||.. ||.|..||. |.. .   .. .| .|. . ... .... |||
kqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vt.rkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhc

SAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
|||.|||| ....  |....| .  .|||..|| || .||..||| |.| | | .|.|..
saGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 535-793 4.2e-71 234.5 In-house 30-285 (297) alignment
Range on Protein: 535-793
Range on HMM: 30-285/297.0
EEFKKLTSIKIQNDKMRTGnlPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQkdSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTE
|||. | . .||.. .       |..|.|   |.||...||.. .   . . |||||||. |...   .|..| |   |..|||.|... .   ||||..
eeflclpeaniqpqtvaek..kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnd

LEERGQeKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPS--DGKGMISIIAAVQKQQQQSGNHPITVHC
..|| . |||.||. .| ...||..|.|.  .|.| .  |.| ||. .  . | ..|..|  ||.  ..   . . .. .|  |.|. .|  . |. |||
dnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhc

SAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
.|| |||| ....  |. ..| |  .|.|..|| || .||..||| |||.| |..| |.. 
laGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall

subfamily_PTPN14_pd Subfamily PTPN14 535-793 1.7e-60 199.5 In-house 27-297 (300) alignment
Range on Protein: 535-793
Range on HMM: 27-297/300.0
EEFKKLTSIKIqNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEeNTDYVNASFIDGY--RQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVML
 |. ...  .  . .. |..|| | .|||. ...||| ||| .   . . .|.|.||| |      .. |||..|||| .|..|||.|.|| .   ||||
teyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TELEERGQEKCAQYWPSD----GLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK---QQQ----
|| || |.||. .|.|..      | .|   |  |  |. .|.. . | .     .. |..  . .  ||. |.|.| ||..| .  ||    . .    
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

-QSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
 .. . |. ||||||.||||       ... .. .  .|. .... || || ..|||| ||.| |||. .|..
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk

subfamily_CG7180_pd Subfamily CG7180 541-795 2.6e-64 211.7 In-house 25-293 (296) alignment
Range on Protein: 541-795
Range on HMM: 25-293/296.0
TSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQ
.  ...... ..|    |..|||  ...||..|||...   |||..||.||...|.. .|  ||  ..|  .|...|||.... .. ..|.||.  .  .
ltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak

eKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNT----------RENKSRQIRQFHFHGWPE-VGIPSDGKGMISIIAAVQKQQQQS----GN
 .. .||| ..   ||.| ||. .|..    . | . .| .           . . | ...|..  |.    .|.  ...| ..  |.. ...      .
.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpee

HPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF
 |. |..| ||.|.| ..|.   || |. |. .|||. || || .||..|.. |.| ..| |..|.. ..
gPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn

subfamily_PTPN3_pd Subfamily PTPN3 544-793 1.3e-66 219.4 In-house 27-277 (280) alignment
Range on Protein: 544-793
Range on HMM: 27-277/280.0
KIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIpvkrGEENTDYVNASFI----DGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERG
| .. .. . ..|.|..|||   |.||.  ||..     |..|||.||...    ..  .   |||.|||| .| .|||.|.|| ||  |||||.| |||
kkpglaisaarkpenlsknryrdilpydatrvkl....kesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverG

QEKCAQYWPSD-GLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQqQSGNHPITVHCSAGAGR
. || ||||.    ..||...|...||.| .|| .|.|..........|.| |. .  ||. |.|.| . .....  |.|.. .. ..|. |||||| ||
rvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr.sgkeePvvvhCsaGigr

TGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEF-CYKVVQEYID
|| . .| | |  . |.  . . . |. .| ||  .||| .||.| |  ... | .
tGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 544-788 8.2e-22 72.7 In-house 5-255 (290) alignment
Range on Protein: 544-788
Range on HMM: 5-255/290.0
KIQNDKMRTGNLPANMKKNRVlQIIPYEFNRVIIPVKRGEENTDYVNASFIDgYRQKDSYIASQGPLLHT-------IEDFWRMIWEWKSCSIVMLTELE
. ... ..|  .  . ...|. ..   | .||.. .     | ||. |...  . .    |..| |. ..       ||.|| |. . |. ..||| | |
estavllktdyvkkhemdqRl.evpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefe

ERGQE----KCAQYWPS--DGLVSYGDITVELKKEEECESYTVRDLLVTNTrENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQqqsgnHPITV
|. ..     ||.| |   .. . ....||. |. |. .   .| |.|.   ...  ..    ..|| .. .. | | ..|.|  |....      |. |
eksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvkask.....tpviv

HCSAGAGRTGTFCALSTVLERVK-AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVV
||  |  |  .. |.      .   .| . . . .|.|| || ..... ... |   ..
HcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagi

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 545-702 1.2e-17 58.4 In-house 83-235 (244) alignment
Range on Protein: 545-702
Range on HMM: 83-235/244.0
IQNDKMRTGNLPANMKKNRVLQIIPYEFNRViiPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERgqekcA
 .   |.    | |  |||    .|..||||  |. .|     |.||||.    .   || .| ||  |  |||.|. | .   .|.|  .||       
pdpsvmkdafnpnnswknregaglpfdfnrv..plskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....d

QYWP-SDGLVSY-GDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGI
.||| |. |  |  |||| |   .|       .| .    ..  . .  |    ||  | 
eywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt

subfamily_PTPRD_pd Subfamily PTPRD 546-798 8.5e-115 379.5 In-house 36-287 (564) alignment
Range on Protein: 546-798
Range on HMM: 36-287/564.0
QNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQ
|. .... | ||| .|||. .|..|. .||..   .|.|..||.|||||||||.. .|||.|||| .||||||||.|| .|..|||||.|||.|..||..
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQqQSGNHPITVHCSAGAGRTGTFCAL
|||..|  .||..||.|..||| . |..|.. ........||..|||||  ||. |.|  .......|  |.. . .....||.|||||| ||||||...
YWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivi

STVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDY
. .|||.|.|. .|..|.|| || ||..|||| ||| |......|....... 
damlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte

0045098 (Phosphotyrosine protein) phosphatases II 546-792 2.4e-87 288.1 In-house 21-272 (278) alignment
Range on Protein: 546-792
Range on HMM: 21-272/278.0
QNDKMRTGNLPANMKKNRVLQIIPYEFNRVIipvkrgeentDYVNASFIDGYrqKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQ
..... ..... |..|||  .|.||...||.          ||.|||.||||  .. .|| |||| .|..|||||.||... .|||||||.|.|.|||||
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNT----RENKSRQIRQFHFHGWPEVGIPSDG--KGMISIIAAVQKQQQ------------QSGNHP
|||..| . |||.||.|..||... ||.|.|||||.     ...|| ....|...||. |.||.   | .....  ... ..            .....|
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

ITVHCSAGAGRTGTFCALSTVLERVkaEGILDVFQTVKSLRLQRPH-MVQTLEQYEFCYKVVQEYI
. |||||| |||||..|. ..||..  || .|....|| || |||. .||.||||.|.|....|..
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 546-795 6.1e-38 125.1 In-house 25-272 (281) alignment
Range on Protein: 546-795
Range on HMM: 25-272/281.0
QNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEE-NTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCA
  |   . | | | |||| |.|   .  || . ||  ..  |||. | .|     |  || .|||   |  |||||||. .. .|||| .. |  .||||
psdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekca

QYWPSDGLVS--YGDITVELKKEEECESYTVRDLlvTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQqqqSgnHPITVHCSAGAGRTGTF
.|.| .  .   .  ..|. .     .|     |    . | ..| | .. .. ||.  .|   . |. |.  .. .   |   |  .||||| ||.||.
eyfprnahcclqfdklsvsyedstvnkslvttrl..nlsyegetrlithwlwkewpdwqvpessevmlkilrkirar...s..tppvihcsagvgrsgtl

CALSTVLERVKAEGIL-DVFQTVKSLRLQ-RPHMVQTLEQYEFCYKVVQEYIDAF
 |.   |. ...   | |. | |  ||.  |   ||||.|| . .||. ..  |.
maveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvay

subfamily_PTPN1_pd Subfamily PTPN1 548-791 6.6e-57 187.4 In-house 22-270 (290) alignment
Range on Protein: 548-791
Range on HMM: 22-270/290.0
DKMRTGNLPANMKKNRVLQIIPYEFNRVIIpvKRGEEntDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYW
 ..|. .||.| ..||   . ||.  |...  .|..   ||.|||...  . | ||| .|||| .|.. ||.|.|| || ..||| .. |..| ||||||
fptreaklpenrnlnryrdvspydhsrikl..eradn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PSDGL---VSYG--DITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNH-PITVHCSAGAGRTGT
|..     . .    ..|.| .||. . |||| | ..| . ...|.| .||.  ||. |.|.    ... .  |..    | .. |  .||||| ||.||
PqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY
|| . |.| ......    .|. ...  || .|  ..|| .| .| |  . | 
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 548-710 4.8e-29 96.2 In-house 23-187 (297) alignment
Range on Protein: 548-710
Range on HMM: 23-187/297.0
DKMRTGNLPANMKKNRVLQIIPYEFNRVIipVKRGEENTDYVNASFIDGYRQ--KDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQ
... . . .. ..|||  .|. .. .||   ..|.  ..||.|| ..    .  .  || .||||  |..|||....|     |||...|.| |..||| 
esfssakrnsslrknryrdilatddtrvk..llrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcap

YWPS--DGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMI
||||  ..    ||. ||   .   |  .|    ..    ..||..|   | .||. |.||| . . 
ywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlv

0040439 (Phosphotyrosine protein) phosphatases II 549-792 4e-89 293.7 In-house 2-246 (249) alignment
Range on Protein: 549-792
Range on HMM: 2-246/249.0
KMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWP
......||.|..|||   |.||...||.. . .| . .||.|||.||||..|. .|| |||| .|.||||||.||... .|||||.|.|.|.||||||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

SDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQS-GNHPITVHCSAGAGRTGTFCALST
..| . |||.||.|...|....|||| | .||. ...||.........||. |.|.. . ....| ||.| ...   ..|. |||||| ||||||.|. .
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

VLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
.||... |. .|....|| || |||..||..|||.|.|....|..
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 549-794 5.4e-63 207.5 In-house 8-266 (270) alignment
Range on Protein: 549-794
Range on HMM: 8-266/270.0
KMRTGNLP---ANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQ-KDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCA
.. . .||    . | ||  .|.|    ||...  . ...| |.|| .. |. . | .|||..|||  |...||||||| |. .|||.|.|||.|..||.
etsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCe

QYWPSDG----LVSYGDITVELKKEEECESYTVRDLLVTntRENKSRQIRQFHFHGWPEVGIPSDGK------GMISIIAAVQKQQQQSGN-HPITVHCS
.|||..      ...|.|.|   .||  | | .. | ..  .. ..|..  |... ||. |.|..         ......||......  . .|. ||||
rYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcs

AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA
|| |||||. || .... .. .. .|| . .. || .|. .||. ||||| ||.|.||.. 
aGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 549-793 4.1e-54 178.3 In-house 29-278 (287) alignment
Range on Protein: 549-793
Range on HMM: 29-278/287.0
KMRTGNLPANMKKNRVLQIIPYEFNRVIIpVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWP
 ... .  |..||||  ...|.. .||.. .. ||  .||.|| .. .|......||.|||.  |. ||||...| .|.|....|   | .. || .|||
tfkaaeelaavkknryadvlPiddtrvll.saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP

SDGL-VSY-GDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV----QKQQQQSGNHPITVHCSAGAGRTGTF
     .   |   | |...     |.|| | . .   ...| ..|...  ||. ...    |.|  .  |    . ... |.  |. ||...|.||.|..
erevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGil

CALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
 |. ....| .  | .|| ..|  || .|  .||.  |. . |. .  |  
latlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

0037934 (Phosphotyrosine protein) phosphatases II 550-792 4.5e-79 260.7 In-house 2-242 (243) alignment
Range on Protein: 550-792
Range on HMM: 2-242/243.0
MRTGNLPANMKKNRVLQIIPYEFNRVIIpvkrgeENTDYVNASFIDGYrqkDSYIASQGPLLHTIED----FWRMIWEWKSCSIVMLTELEERGQEKCAQ
.....||.|..|||.  |.||...||..      |..||.||..|...   . .||.|||| .|.||    ||||.||... .|||||||.|.|.|||||
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPsDGLvSYGDITVELKKEEECESYTVRDLLVTNTR-ENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQ-------SGNHPITVHCSAGAG
||| ..   |||.||.|..||....|||| ||..|.  .. .|.....|...||. |.|.. . ..... .|.. ...       ....|. |||||| |
ywp.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGTFCALSTVLERVkaeGiLDVFQTVKSLRLQRPH-MVQTLEQYEFCYKVVQEYI
||||..|. ..|...   | .|....|| || |||. .|||..||.|.|....|..
RtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell

0042113 (Phosphotyrosine protein) phosphatases II 551-792 2.1e-89 294.4 In-house 2-243 (245) alignment
Range on Protein: 551-792
Range on HMM: 2-243/245.0
RTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD
....||.|..|||  .|.||...||....  |.. .||.|||..||||... .||.|||| .|.||||||.||... .||||||.||.|..|||||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLE
. . |||.||.|..|| ...|||| | |||.....||.....|...||. |.|.. . ..... .|.|......|.|. |||||| ||||||.|. ..||
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
....|. ......|| || |||..|||..||.|.|....|..
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell

subfamily_egg_pd Subfamily egg 551-791 1.4e-24 81.3 In-house 33-269 (307) alignment
Range on Protein: 551-791
Range on HMM: 33-269/307.0
RTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERgqEKCAQYWP--
.|     |..| |  ..   .. || . ..||    |.. |  ..|    . .| .| ||  | .|||||... .   |||||   |   |.|  |||  
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka

-SDGLVS-YGDITVELKKEE-EC-ESYTVRDLLVTNTRenksrqIRQFHFHGW-PEVGIPSDgkgMISIIAAVQKQQQQSgnHPITVHCSAGAGRTGTFC
 || ||   | . .|  | . .    ..|  | .  .         . .   |  .|   ||   . | .  ..| .. |  .|. |..  |  ...|. 
esdslvtvpGslrienlkvdskadplfrvtklklvGgd......deerflehwqgdvnnssd...vysplrvlrklrnls..kpvvvqdilGvskaatlv

ALSTVLERVKAEGIL--DVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY
|. . |  .    |    | ..|. |||.|.  |..  .| | |..|  .
aieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff

subfamily_eak_pd Subfamily eak 551-704 2.1e-19 64.1 In-house 45-196 (332) alignment
Range on Protein: 551-704
Range on HMM: 45-196/332.0
RTGNLPANMKKNrVLQIIPYEFNRVIIPVKRgEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD
. ..   ....| |..|.||... | .   .  ..  |.||| ..       || .  .    .  ||.|. | || .||.| |  | . ||  .|.| .
setarleavnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

G--LVSYGDITVELKKEEECESYTVRDLLVTNtrENKSRQIRQFHFHGWPEVGIPS
.   ...| . || |.  . . . .| | ..    |.. ..  ....|| |. .| 
treelkfGildverkefvkrniletrllelsk..GnethrvlhykvfGwtettlpk

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 552-792 4.3e-23 76.4 In-house 41-279 (303) alignment
Range on Protein: 552-792
Range on HMM: 41-279/303.0
TGNLPANMKKNRVLQIIPYEFNRVIIpvkrgeENTDYVNASFIDGYRQKDSyIASQGPLLHTIEDFWRMIWEWK-SCSIVMLTELEERGQEKCAQYWPSD
  ..  ||.|||  ..|  .  .| .       .. |. ||...   .| . | .| || ||  |||.|| | |  | ...||. |         .   .
knqfvknmdknrfvdvicldhskvkl......sdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnq

GLVSYGDITV---ELKKEEECESYTVRDLLVTNTReNKSrQIRQFHFHGWPEVGIPSDGK-GMISIIAAVQKQQ-QQSGNHPITVHCSAGAGRTGTFCAL
 .. . . ..   |.|. |  . .... | |.|    ||  .   |.. ||   |||||   ..  |  .|    . | ..|      .| ||.|||. .
dflkfeersirvgefkrvelgdgwvlkvlsvsngd.yks.flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalf

STVLERVKAE-GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
 |    ...|   ||. . .. .|  | | || | |. . | .. |..
etahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 554-800 5.5e-95 312.3 In-house 5-250 (250) alignment
Range on Protein: 554-800
Range on HMM: 5-250/250.0
NLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEkCAQYWPSDGLV
. |.| .|||  .||...  ||..  ..|....||.||||..||......||.|||| .||||||||..| || .|||||.|.| ... . |||| ..  
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae

SYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVK
 |||.||.|...||   ||.| | .........|..||.||  ||. |.|   . .. ..  ||..|||.|| |. |.|||| ||.|.|.|...||||.|
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYAN
 | ..|||. .| || .|||.|..|||| |.|.......|...|||.
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar

subfamily_PTPRK_pd Subfamily PTPRK 557-790 2.6e-81 267.9 In-house 42-275 (314) alignment
Range on Protein: 557-790
Range on HMM: 42-275/314.0
ANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVsYG
 | .|||. .|..|.  ||.. .  |. ..||.||..||.|..   .|. |||| .|..||||.... ...|||||||| | |. || .||| |. | ||
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.yg

DITVELKKEEECESYTVRDLLVTN--TRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQsGNHPITVHCSAGAGRTGTFCALSTVLERVKA
|| ||| . |  . . || . |..     .. |..|||.| |||. ..|   .|...... |.|.|.. .. .| |||||||||||||.|...||. .. 
dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmier

EGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE
||..|||..||.|| ... ||.| ||| |.| |. |
egvvdvfnavktlrsrkvnmveteeqykfiydvile

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 557-795 5.8e-41 135.0 In-house 53-286 (290) alignment
Range on Protein: 557-795
Range on HMM: 53-286/290.0
AN--MKKNRVLQIIPYEFNRVIIpvKRGEeNTDYVNASFIDGYrqKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD--GL
.|  .||||  ...  .  |||.  | |  . ||| | ...|   |  .| .||.|  |. |.|||. . |   |||| || | |. ||.||.|      
kntefkknrykdvvcndktrvil..kdGy.dGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

VSYGDITVELKKEEECESYTV-RDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKqqqQSGnhPITVHCSAGAGRTGTFCALSTVLER
...|.|||   .|.. .. .. . | | .  . |. ... ..   ||.  ..     .. .. ...|    ||  |..|||||| |||||| |. . |. 
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk...asG..pvvvhcsaGiGrtGtfvaievglqi

VKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF
.     ||. ..|..||  |   ||   ||    ... ..  .|
lldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdf

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 557-792 2.9e-34 113.4 In-house 34-270 (285) alignment
Range on Protein: 557-792
Range on HMM: 34-270/285.0
ANMKKNRVLQIIPYEFNRVIIpvKrgEENTDYVNASFIDG-YRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD--GLV
||   ||  ..   |  ||..  |  . . ||. ||..    ... .||..||||  |. |||.||.. | . ..||  | | | |||| |.|     .|
anpdlnryadvrcieetrvvl..k..nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

SYGD--ITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHF--HGWPEVGIPSDGKGMISIIAAVQKQQQQsgNHPITVHCSAGAGRTGTFCALSTVL
 .|   ||.   |||      .  | |.|| .  |  .   |     ||.   | | . || .   |.| . .  ..|| |||||| ||| ||  .    
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyat

ERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
 |.  .  ..... |. .|  | . ||.  |. | | |. ||.
irimenpniemldivremramrfqavqshmqflflyvvlmeyf

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 557-792 1.4e-32 107.9 In-house 42-271 (288) alignment
Range on Protein: 557-792
Range on HMM: 42-271/288.0
ANMKKNRVLQIIPYEFNRVIIPvkrgEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD--GLVS
||  ..|  ..   .. || .     ..   |..|  .   . |   | .| ||  ||| .|.|. |     ||||.|| |.|.|| |.|.||     . 
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGDITVELKKEEECESYTVRDLLVTNTRENKSRQ-IRQFHFHGWPEVGIPSDGKGMISIIAAVqkqqqQSGNHPITVHCSAGAGRTGTFCALSTVLERVK
.| .    ||. .    .|.  |. ...| . .. ... |.. |.. |.| . .  . ..  .     .| ..|| ||.|||.|||||.     .|| ..
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslr

AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
 .  | . . ...|| .| . .||  || . ...| |..
lddflgirsllaklreerfkaiqtemqylyvhrcvleel

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 557-792 1.6e-32 107.4 In-house 52-289 (305) alignment
Range on Protein: 557-792
Range on HMM: 52-289/305.0
A--NMKKNRVLQIiPYEfNRVIIPVKRGEeNTDYVNASFIDGYR-QKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS---D
|  .. |||  .. | . .. .. ...    .||. | ..      .  .|..|||| .||..|| |. . |   ||||    | |. |||||||    .
adiaitknryqdv.pcq.dqsavkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

GLVSYGDITVELK---KEEECE-SYTVRDLLVTNTrENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQqqsgnHPITVHCSAGAGRTGTFCALS
 |   . | ||     |  | .    .  | .| .  ...  .|....  ||. |.|      . ...|..  .      || |||||| |||||  |. 
klelksgivvenvsgskpmerdaeiqitllnltys.gdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagigrtgtivaie

TVLERVKAE-GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
 .||..  .     . . ||.|| || . .|.  || | ..|. .|.
yilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 557-650 7.8e-13 42.6 In-house 33-124 (332) alignment
Range on Protein: 557-650
Range on HMM: 33-124/332.0
ANMKKNRVLQIIPYEFNRVIIPVKRGEEntDYVNASFIDGYRQKDSYIASQGPLL-HTIEDFWRMIWEWKSCSIVMLTELEERGQEKcAQYWPSD
 ||  ||. ..  ....|| .  . |..  |. |||..||| .| .|| .| |.  ||   ||||. | |   |... ...|. . | | |  ||
nnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk.apydisd

Y_phosphatase Protein-tyrosine phosphatase 558-790 3.1e-89 293.8 Pfam-A 1-235 (235) alignment
Range on Protein: 558-790
Range on HMM: 1-235/235.0
NMKKNRVLQIIPYEFNRVIIpvKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWP--SDGLVSY
|.||||  .|.||...|| .  |  |...||.||....||..| ..||.|||| .||||||||.|. |. .|||||.|||.|.||||||||  ... ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDITVELK-KEE-ECESYTVRDLLVTNTRENK-SRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQqQSGNHPITVHCSAGAGRTGTFCALSTVLERV
|||.|||| ||. ....||.|.| .... |.. .|...|.|...||. |.|.. |.....| .|.|.. .. ..|..||||||.||||||.||...||..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE
.||. .||.|.||.|| |||.|||.||||.|.||...|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

Y_phosphatase Protein-tyrosine phosphatase 558-790 3.1e-89 293.8 In-house 1-235 (235) alignment
Range on Protein: 558-790
Range on HMM: 1-235/235.0
NMKKNRVLQIIPYEFNRVIIpvKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWP--SDGLVSY
|.||||  .|.||...|| .  |  |...||.||....||..| ..||.|||| .||||||||.|. |. .|||||.|||.|.||||||||  ... ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDITVELK-KEE-ECESYTVRDLLVTNTRENK-SRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQqQSGNHPITVHCSAGAGRTGTFCALSTVLERV
|||.|||| ||. ....||.|.| .... |.. .|...|.|...||. |.|.. |.....| .|.|.. .. ..|..||||||.||||||.||...||..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE
.||. .||.|.||.|| |||.|||.||||.|.||...|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 558-792 2.9e-72 238.4 In-house 43-276 (515) alignment
Range on Protein: 558-792
Range on HMM: 43-276/515.0
NMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSY
| ||||   |.||. .||.. |   . . ||.|||.| ..    .|||||||.  ...||||.... .   |.|.|.|.|  . ||..|||      | .
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

GDITVELKKEEECESYTVRDLLVtnTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGnHPITVHCSAGAGRTGTFCALSTVLERVKAE
| | |||   | |   . | | |  .....|| . ||||..||. |.| . . .. .| .|. ...|   ||. .|||||.|||| ....  |. ..|  
Gsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahaktt

GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
 ..|||..|. .| .||..||| ||| | | .|.|..
rmvdvfnfvtnirqkrpylvqtqeqyafiygavledl

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 558-788 8.1e-56 183.9 In-house 3-235 (237) alignment
Range on Protein: 558-788
Range on HMM: 3-235/237.0
NMKKNRVLQIIPYEFNRVIIpvKRGEENTDYVNASFIDGYRQ-KDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS-DGLVSY
|  |||  .|. |. .||..  |    ..||.||....|.     .|||.||||  . .|||.|.|. |   ||||| | |. ..|| .|||| |   .|
nkiknrygnivaydhsrvvl..kgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GDITVELKKEEECESYTVRDLLVTNTRENK-SRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQ-SGNHPITVHCSAGAGRTGTFCALSTVLERVK
| .|| |||.||   |||| ||...  . |  | | |..|  ||. |.|     .. .   . .. .  |   |  .||||| |||| |  . ..| . |
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVV
 . ..|... |.|.  .||...|| .|| | ....
ekkvvdiynyvysieedrpyiiqtkdqyvfihqti

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 558-789 2.4e-53 175.8 In-house 7-237 (239) alignment
Range on Protein: 558-789
Range on HMM: 7-237/239.0
NMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQ-KDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPsDGLVSYG
|  |||  .|. |...||..     .  .||.|||..  |     .|||.|| .  .  |||||.|. . | ||||| | |  ..|| |||| |    | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstskyc

DITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQqQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEG
.. | |.| |    | .| .....  . . | . |.||  ||. |.|     .. .   . |.    | .|  .||||| ||||.|  . ..| . | . 
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrtgaflvidamlrqakkqk

ILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQ
 .|.|. ||..| .||||||| ||| | .  | 
tvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 558-788 2.7e-53 175.6 In-house 8-237 (239) alignment
Range on Protein: 558-788
Range on HMM: 8-237/239.0
NMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQ-KDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPsDGLVSYG
|  |||  .|. |...||..     .  .||.|||..  |     .|||.|| .  .  |||||.|. . | ||||| | |  ..|| |||| |    | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstskyc

DITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQqQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEG
.. | |.| |    | .| .....  . . | . |.||  ||. |.|     .. .   . |.    | .|  .||||| ||||.|  . ..| . | . 
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrtgaflvidamlrqakkqk

ILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVV
 .|.|. ||..| .||||||| ||| | .  |
tvdifnyvkairedrphmvqtseqyvfihlav

0041856 (Phosphotyrosine protein) phosphatases II 558-792 2.4e-50 166.0 In-house 1-171 (182) alignment
Range on Protein: 558-792
Range on HMM: 1-171/182.0
NMKKNRVLQIIPYEFNRviipvkrgeeNTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTeleergqekCAQYWPsdglvsygd
|..|||.  |.||...|          . ||.||....|..  . .|| |||||.|..||.||..|..  .||.||         . .|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

itvelkkeeecesytvrdllvtntrENKSRQIRQFHFHGWPEVGIPSdGKGMISIIAAVQKqqqqsGNHPITVHCSAGAGRTGTFCALSTVLERvkaeGi
                         |.  |.. |.....||  |.|.    ....| .|..      ..|. |||||| |||||..|.  ....    | 
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.

LDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
......|| .| .||.||.|..|| |.. .. |..
vsleeavklvrsrRpgmvitpnqyfflqlallell

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 558-667 9.2e-23 75.5 In-house 47-167 (350) alignment
Range on Protein: 558-667
Range on HMM: 47-167/350.0
NMKKNRVLQIIPYEFNRVIIP--------VKRGEENTDYVNASFIDGY----RQKDSY--IASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKC
 . |||  .|.||| .||...        .|   .  ||.||...       ... ..  || |.||  |..||...| . |   |..||.. | . |||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

AQYWPSdglVSYGDITVELKKEEE
 .||.     || |||| |.   |
yrYWqe...gsydditvklaskwe

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 558-634 8.8e-08 26.0 In-house 37-118 (347) alignment
Range on Protein: 558-634
Range on HMM: 37-118/347.0
NMKKNRVLQIIPYEFNRVIIPV-----KRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTE
...|||  .    .  ||..        | ..   |.||| |     .  || .| || .|. |||.|.   |   .| . |
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 559-666 1.8e-11 38.0 In-house 49-169 (349) alignment
Range on Protein: 559-666
Range on HMM: 49-169/349.0
MKKNRVLQIIPYEFNRVIIPVK--------------RGEENTDYVNASFIDGYR--QKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEK
. |||  .|.|||  ||...                 .    ||.|| ..   |   .  ||| | ||  |..||...|   .   .. |.. .| . ||
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CAQYWPSdglVSYGDITVELKKEE
| .||      || .||| |.   
cdiywqe...lsysnitvklqnss

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 568-701 1.8e-10 35.2 In-house 3-125 (130) alignment
Range on Protein: 568-701
Range on HMM: 3-125/130.0
IPYEFNRVIipvkrgeeNTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERgqekcAQYWPSDGLVS-Y-GDITVELKKE
...|..|.         . .|.||||.    .   |. .| ||  |  |||.|. |     .|.|  .||       .|||    .  |  ||.| | . 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdr

EECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVG
.| .      | . .   .  . .  |.   ||  |
defknikasnleiesdlneshqaltmfqisnwpsdg

0044763 (Phosphotyrosine protein) phosphatases II 569-791 1.9e-36 120.7 In-house 1-170 (178) alignment
Range on Protein: 569-791
Range on HMM: 1-170/178.0
PYEFNRVIIPVKRGEENTDYVNASFIDGYrqkdSYIASQGPllhtiEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLvsygditvelkkeeec
|....||...  .|.| .|| |||.|...     |..|..|     .|......|..  .||.|||  |.|..|| .|||..                  
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

esytvrdllvtntrenksrqiRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQqSGNHPITVHCSAGAGRTGTFCALSTVLERvkaeGIlDVFQTVKSLR
                      |... ..|  | |.  . .  ....... .. . ..|. |||||| ||.||..|.  ....    |. .... .. .|
.....................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvr

LQRPhMVQTLEQYEFCYKVVQEY
 .|| .|.. .|....|.. ...
erRp.ivpnpgqlrqLyefelrl

0046846 (Phosphotyrosine protein) phosphatases II 580-792 1.4e-44 147.2 In-house 6-173 (176) alignment
Range on Protein: 580-792
Range on HMM: 6-173/176.0
KRGEENTDYVNASFIDGYRqkdsYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSdgLVSYGDitvelkkeeecesytvrdllvt
   ... ||.||..|.|.|    .|| |||| .|..||..|..|..   .|.|||. | |. ||..|||   | ..|                       
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi......................

ntrenksrqirQFHFHGWPEVGIPSDgKGMISIIAAVQKQQQQSgnHPITVHCSAGAGRTGTFCALStvleRVKAEGILDVFQTVKSLRLQRP-HMVQTL
           |.....||. |.|.. . ..............   .|. |||||| |||||..|.      .. |  |.|..... .| ||| ..||| 
...........qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

EQYEFCYKVVQEYI
|||.|.|.......
eQyrflyefellll

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 581-794 1.9e-23 77.7 In-house 63-278 (312) alignment
Range on Protein: 581-794
Range on HMM: 63-278/312.0
RGEENTdYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS-DGLVSYGDITVELKKEEECE-------SYT
 |.||  |. | |.    . . ....||||  |.  ||..     |.||..|. . | | ||||.|     |.|   |  |  .   | |         |
agdenf.yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkit

VRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQqsgnhPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRP
 | | |      .  .. .. .  ||. |.|        ...||.|...     |.  ||||| |||||.. . ...  ..     .| ..   || .| 
hrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdra

HMVQTLEQYEFCYKVVQEYIDA
  |... || .. ..| |.. .
rsvrvfpqyvyalrcvleflys

0043147 (Phosphotyrosine protein) phosphatases II 582-786 1.4e-44 147.2 In-house 1-155 (172) alignment
Range on Protein: 582-786
Range on HMM: 1-155/172.0
GEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELeergqekcaqywpsdglvsygditvelkkeeecesytvrdllvTNT
|.|..||.|||..|.|.  |..|| |||| .|..|||||..|..   ||.||||                                           ...
gdegsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lyd

RENKSRQIRQFHFHGWPEVGIPsDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLervkaEGIlDVFQTVKSLRLQRPHMVQTLEQY
.|. .|.. |.....||  | | . . .....  ... ...| ..|. |||||| |||||..|.  .|     .|. .....|. .| .||..||. .||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqy

EFCYK
 |.|.
rflyy

0051429 (Phosphotyrosine protein) phosphatases II 586-795 7.6e-59 194.8 In-house 4-228 (272) alignment
Range on Protein: 586-795
Range on HMM: 4-228/272.0
TDYVNASFIDGYRQ---KDSYIASQGPLLHTIEDFWRMiWEWKSCSIVMLTELEERGQEKCAQYWP------------SDGLVSYGDITVELKKEEECES
..|.||....|| .   .. ...|.||| .|..||||. .|..  .||.|...||||..|| .|||            |.  ..||...| | .|| .. 
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YTVRDLLVTNT-RENKSRQIRQFHFHGWPEVGIPSDGkgMISIIAAVQKqqqqsgNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILD--------VF
|..| ||.|..   ...|.....|...||  |.|..   ..........      ..|. |||||| .||||..||  .|..| .| |.|        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

QTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF
..|. || |||..||| |||.|.|....|.....
eaveelraqrpgavqteeqylflyeallellrsl

0036282 (Phosphotyrosine protein) phosphatases II 586-786 3.9e-51 168.5 In-house 2-164 (174) alignment
Range on Protein: 586-786
Range on HMM: 2-164/174.0
TDYVNASFIDGYRQKDSYIASQGPLLhtiedFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSdglvsygditvelkkeeecesytvrdllvtnTRENK
.|| |||..|...  . .||.||||      ||.|..|... ..|||.|..|.| .|| .|||.                               .||  
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

SRQIRQFHFHGWPEVGIPSDGKgMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKaEGILDVFQTVKSLRLQRPHMVQTLEQYEFCY
.| . |... .||  | |.. . ..... .|.. .......|. |||||| |||||..|.  .| . . |.  |....|..||||||.|||| .||.|.|
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

K
.
y

0051082 (Phosphotyrosine protein) phosphatases II 586-788 1.7e-38 126.9 In-house 3-149 (151) alignment
Range on Protein: 586-788
Range on HMM: 3-149/151.0
TDYVNASFIDGYrqkdsYIASQGPllhtIEDFWRMIWEWKSCSIVMLTELEERGqeKCAQYWPSDGlvsygditvelkkeeecesytvrdllvtntrenk
.|| |.|...|.     ...|.||     .||.....|..  .||.|...||||  .|..|.|. |                                  
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg..................................

sRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKqqqqSGNHPITVHCSAGAGRTGTFCALSTVLERvkaegiLDVFQTVKSLRLQRPHMVQTLEQYEFCY
 ..........||. |.|   . ..... ....     .|.|. |||||| |||||..||  .|..      ........ .||.||..||. .|. |..
.ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

KVV
...
fal

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 588-781 2.6e-28 93.6 In-house 77-270 (301) alignment
Range on Protein: 588-781
Range on HMM: 77-270/301.0
YVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDG--LVSYGDITVELKKEEEC--ESYTVRDLLVTNT-R
 . | .|.   . . .||.||||  | |||| |.  ..   ||||..  |. .|||..| |..    .  |  ....|..|    .. . | | |... .
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

ENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQqqqsgNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQY
. ..| .  . .. |.. |.|     .  ..  |.|      ..|| |||||| ||. .| .   .  .|.|.  ... ...| || .| . ||| .| 
kfatrtvthyqysewtdrgvPkshaelfdlmelvkks.....ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql

0049260 (Phosphotyrosine protein) phosphatases II 593-786 5.9e-41 135.0 In-house 1-144 (152) alignment
Range on Protein: 593-786
Range on HMM: 1-144/152.0
FIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWpsdglvsygditvelkkeeecesytvrdllvtntrenksrqirQF
|||||...  .|| |||. .|..|||||..|..   |||||||.|.| .||.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

HFHGWPEVGIPSDGKGMISIIAAVQKQqQQSGNHPITVHCSAGAGRTGTFCALSTVLervkaeGILDVFQTVKSLRLQRPHMVQTLEQYEFCYK
... ||  | |..   .. .. ...|  ... ..|. |||||| |||||..|.  .|        ......|. .| .||..|.. .|..|.|.
lhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 595-678 4.9e-13 43.2 In-house 230-311 (440) alignment
Range on Protein: 595-678
Range on HMM: 230-311/440.0
DGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERgqeKCAQYWPSDG-LVSYGDITVELKKEEECESYTVRDLLV
.|| .|...||.| ||  |. ||||.. ...  .|.|| .|...    |. ||| .   |..| .||  |  |. .   || | .
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlel

subfamily_hpo-7_pd Subfamily hpo-7 598-788 6.4e-19 62.9 In-house 35-223 (263) alignment
Range on Protein: 598-788
Range on HMM: 35-223/263.0
RQKDSYIAsqgpLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEEceSYTVRDLLVTNTRE--NKSRQIRQFH
..|..|.     |. ||. |...|   |.  .|||.. .| |.||| .|.|   |.   . ...|   |  .     .. | ...| .   | ...... 
krknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhys

FHGWPEVGIPSDGKGMISIIAAVQKqqqqSgnHPITVHCSAGAGRTGTFCALSTVLE------RVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKV
. ||.|.  | . . .. |. ....    |  ... ||||.| ||.  |    .|        .    . ||  . .. || .|.  ..|  |  |   .
ykgWiekndpelareilnilkvarn....s..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilm

V
|
v

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 599-791 1.3e-19 65.3 In-house 33-220 (255) alignment
Range on Protein: 599-791
Range on HMM: 33-220/255.0
QKDSYIAsqgpllhTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHG
.|..|.        |.. |...|   |.  .|||....| |.||| .|.|   |.   . |..|   |         .... | ..  | .... ....|
rknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykG

WPEVGIPSDGKGMISIIAAVQKqqqqSgnHPITVHCSAGAGRTGTFCALSTVLE------RVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE
|.|   | . . .  |. .|..    |  ... ||||.| ||. .|     |        .    . ||  . .. || .|.  ..|  |  |.  .| .
WieknaPelareilnilkvvrd....s..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld

Y
.
l

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 600-787 2.4e-27 90.4 In-house 4-199 (199) alignment
Range on Protein: 600-787
Range on HMM: 4-199/199.0
KDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTVRDLLVTN--TRENKSRQIRQFHFH
.  |||.| || .|. |||.|.||  |  |||. . .   .   . |||.   |   || ..|  |       ||.  |..||  |    .|.| .. | 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

GWPEVGIPSDGK--GMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLE---RVKaEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKV
 | |   |      |..     | |. .|  . |. |||| | | || | ||   .      |   ..|.|.  | ||  |  .. .|..|.| |.|
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 601-787 2.8e-27 90.2 In-house 4-198 (198) alignment
Range on Protein: 601-787
Range on HMM: 4-198/198.0
DSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTVRDLLVTN--TRENKSRQIRQFHFHG
  |||.| || .|. |||.|.||  |  |||. . .   .   . |||.   |   || ..|  |       ||.  |..||  |    .|.| .. |  
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEVGIPSDGK--GMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLE---RVKaEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKV
| |   |      |..     | |. .|  . |. |||| | | || | ||   .      |   ..|.|.  | ||  |  .. .|..|.| |.|
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 605-783 5.5e-18 59.4 In-house 95-279 (302) alignment
Range on Protein: 605-783
Range on HMM: 95-279/302.0
ASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVE-------LKKEEECESYTVRDLLVTNTRENKS--RQIRQFH
    |   |.| .| .| ... . .| |... | ...|||.|.    .| . .|  ||.       |..  . .|...  . ..|.. .|   . .  ..
kpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdila

FHGWPEVGIPSDGKGMISIIAAVQkqqqqSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEF
| .||. | | . .  . |.   .     |  . . |||||| |||||. |.   ..  . . . |. . |. .|  |   ||. .|  .
fsawpdhGapkeaytaldilkfce.....sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 614-793 4.3e-08 26.1 In-house 131-310 (346) alignment
Range on Protein: 614-793
Range on HMM: 131-310/346.0
IEDFWRMIWEWKsCSIVMLTELEERGQEKCAQ-YWPSDGLVSY-GDITVELKKEE---ECESYTVRDLlvtnTRENKSRQIRQFHFH-GWPEVGIPSDGK
.|||| ||.. .   .| |   ... ..  .  .   .|   | | . .. .. .   .   ||.  |       |    | | | |  |  .  |    
vedfwymiyqeq.ihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievl....pegnsdsvicqvhhhapwkhlqqppktl

GMISIIAAVQKQQqQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
 .| .|     .. |  |  . |    |.||. .|      ....      .... .|... |||  |... ||   | .| .|| 
piikmihqflsek.qvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyia

0048076 (Phosphotyrosine protein) phosphatases II 655-791 7.4e-26 86.0 In-house 13-142 (145) alignment
Range on Protein: 655-791
Range on HMM: 13-142/145.0
YGDITVELKKEEEC--ESYTVRDLlvTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQsgNHPITVHCSAGAGRTGTFCALSTVLErv
.|.... |. |. .    .|| .|  |...|. .|.. |... .||  |.|.. . .......... ...  ..|. |||||| |||||..|.  .|.  
lgslptaldlellkdlgittvlnl..tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll..

kaEGiLDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY
  .| ........ .| |||..|.. .|..|.|....|.
..lg.vsleealelvrsqrpgavpnpgqlrflyefelel

0048179 (Phosphotyrosine protein) phosphatases II 668-786 1.3e-23 78.7 In-house 28-139 (144) alignment
Range on Protein: 668-786
Range on HMM: 28-139/144.0
CESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQqsGNHPITVHCSAGAGRTGTFCALSTVLervkAEGiLDVFQTVKSL
   .|| .|  .   |   |.. |... .||  |.|.. . .......... ..   ..|. |||||| |||||..|.  ..     .| |....... .
lgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalv

RLQRPHMVQTLEQYEFCYK
| .||..|.. .|..|...
rsrrpgavpnpgqlrfLle

0038934 (Phosphotyrosine protein) phosphatases II 673-794 1.7e-10 36.3 In-house 60-179 (194) alignment
Range on Protein: 673-794
Range on HMM: 60-179/194.0
VRDLLVTNTRENKSRQIR-QFHFHGWPEVG--IPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLErvkaEGIlDVFQTVKSLRL
| ||  |..  ....  .  .... .| ..   . . . . ... .|..  ... .. . ||| || |||||..|   .       |. .. . .. .| 
vidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr....lgm.saeeAialfre

QRPHMVQTLEQYEFCYKVVQEYIDA
 ||..... ...|  .| ..|...|
kRpgaipnqdyleallkrykelrka

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 685-791 4.4e-25 82.9 In-house 87-193 (440) alignment
Range on Protein: 685-791
Range on HMM: 87-193/440.0
KSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFC
.|| ..|.|..|||. |.|     .. .|  |.. |...|| |. |||||||||||   |. ..|  .|    .|.|  ..|.| .||.|||| ||| | 
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

YKVVQEY
...| | 
heavleg

PTEN_1 686-775 4.7e-06 21.5 In-house 92-182 (196) alignment
Range on Protein: 686-775
Range on HMM: 92-182/196.0
SRQIRQFHFHgWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCA-LSTVLERVKAEGILDVFQTVK-SLRLQRPHMV
 ..... ||. ..  | ||  . .  .  . .  .... .. . ||| || ||.|| .| .   ...  |.  |. ..      ... |.. 
ksgveylhfp.ieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqe

PTPc_DSPc_SM00012 689-789 8e-37 121.0 In-house 2-104 (105) alignment
Range on Protein: 689-789
Range on HMM: 2-104/105.0
IRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAE-GILDVFQTVKSLRLQRPHMVQTLEQYEFCYK
....|..|||. |.|.... ......||.|....|. ..|. ||||||.||||||.||...|.....| . .|.||.||.|| |||.||||.||| |.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VVQ
...
all

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 691-791 6.9e-15 49.6 In-house 219-343 (350) alignment
Range on Protein: 691-791
Range on HMM: 219-343/350.0
QFHFHGWPEVGIPSDGKGMISIIA---------AVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLE---------------RVKAEGILDVFQTVKS
|.... |.....  . . .....            ..  ...   || |||||| |||||...|  .|.                | |.    ....|. 
qlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivne

LRLQRPHMVQTLEQYEFCYKVVQEY
|| ||  |||.|.|. |.|. .. |
lrkqrismvqnldqfifiYeallfy

subfamily_PTPDC1_pd Subfamily PTPDC1 691-787 1.4e-08 29.4 In-house 84-171 (182) alignment
Range on Protein: 691-787
Range on HMM: 84-171/182.0
QFHFHGWPEVGIPSDgKGMISIIAAVQkQQQQSGnhPITVHCSAGAGRTGTFCALSTVLERVkaegiLDVFQTVKSLRLQRPHMVQTLEQYEFCYKV
 ..  ||.. | .|  . .. |.  |. .  | |   ..||| || ||||   |   |  .      |.  ...| .| .||. .|| || |.. . 
yvynfgwkDygvasl.eriLdivkvva.falqeg..kvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvkef

subfamily_CG42327_pd Subfamily CG42327 719-792 2.7e-16 54.1 In-house 241-315 (319) alignment
Range on Protein: 719-792
Range on HMM: 241-315/319.0
QQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAE-GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
  ... . |..|||| |.||||.  |    .....     .|. |.| |.| .| . |.| ||||| |||..|| 
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 720-792 4.6e-11 36.6 In-house 260-344 (349) alignment
Range on Protein: 720-792
Range on HMM: 260-344/349.0
QQQSGNHPITVHCSAGAGRTGTFCALSTVLE----------RVK--AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
 ...   .. |||||| ||||... |  .|.          ..|  |     .. .| .|| ||  ||| | |. ..|. . .|.
ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 721-789 2.5e-15 51.1 In-house 224-292 (297) alignment
Range on Protein: 721-789
Range on HMM: 224-292/297.0
QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQ
..  | .. |||||| ||.|      ..|.... . | ||   .. || ||. .||||||.|..|..| 
emprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl

subfamily_DSP23_pd Subfamily DSP23 723-785 2.1e-06 22.5 In-house 82-139 (148) alignment
Range on Protein: 723-785
Range on HMM: 82-139/148.0
SGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGildvfQTVKSLRLQRPHMVQTLEQYEFCY
. |  ..|||  | |||||. |   | ||  | .     ...  .| .||  |.|.|| .  .
ekneavsvhcllgrgrtgtmlacylvkerklaaa.....eaiaevrrlrpgsvetveqeklvr

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 729-788 8.3e-14 45.7 In-house 2-61 (69) alignment
Range on Protein: 729-788
Range on HMM: 2-61/69.0
TVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVV
 ||||.|.|||||| |.   . |.|.| ..|.|  |. .|  || ||    .| | .  .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 730-790 7.3e-14 45.9 In-house 2-62 (69) alignment
Range on Protein: 730-790
Range on HMM: 2-62/69.0
VHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE
||||.|.|||||| |.   . |.|.| ..|.|  |. .|  || ||   ..| | .  . |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve

subfamily_ptpA1_pd Subfamily ptpA1 758-791 8.4e-07 23.1 In-house 364-397 (418) alignment
Range on Protein: 758-791
Range on HMM: 364-397/418.0
LDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY
...|  |  || ||| ||| |||| |||| . . 
fnlfsivlklreqrpgmvqqleqylfcyktilde