Gene PTPRA in Homo sapiens

Synonym: HEPTP, HLPR, HPTPA, HPTPalpha, LRP, PTPA, PTPRL2, R-PTP-alpha, RPTPA, RP4-534B8.1, PTPRA

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRA
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP088_AA protein Get Run
HsapP088_AA_223-503 phosphatase_domain Get Run
HsapP088_AA_515-793 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
DUF3357 Domain of unknown function (DUF3357) 130-200 6.9e-06 12.4 Pfam-A 10-73 (107) alignment 
Range on Protein: 130-200
Range on HMM: 10-73/107.0
TTPETFPPSGNSdS-KDRRdetPIIAVMVALSSLLVIVFIIIVLymlrFKKYKQAGSHSNSFRLSNGRTEDV
  ||. ...... | . ||   |.  ... |||||........|     .. .|. ..... . |. .....
pLpegdesasep.sarrrr...plkvllavlsslllllllvall....vvskgqspdgdeaasssseespes
0050432 (Phosphotyrosine protein) phosphatases II 207-507 7.5e-107 352.4 In-house 12-304 (308) alignment 
Range on Protein: 207-507
Range on HMM: 12-304/308.0
LLARSPSTNRKYPPLPVDKLEEEINRrmADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLtpveGvPDSDYINASFINGY--
|| |..|.. .. .|.|..| . ...  |.|..|..|||..|.....  ....|...|||.||||..|||||||||.|    . ..|||||||...||  
llfrdtsilvsslklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyss

QEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ---GCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGdmtnRKPQRLIT
  ..||||.|||...||.|||||.||||. .|||.|.| |..  |||||||.    |...||...| . ...|| |||||..... .|     .. | .|
klprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg....dgesrtvt

QFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQyaGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
.||.|.|||.|||  |  .|.||..|. ..|.  | |||||||||||||||...| .|.....|..|||.. | ..| ||..|||| .||.|.|.||||.
hfhytnWpdhgvPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralley

YLYGDT
...  |
lklklt
subfamily_PTPRA_pd Subfamily PTPRA 209-537 4.7e-203 668.2 In-house 2-330 (330) alignment 
Range on Protein: 209-537
Range on HMM: 2-330/330.0
ARSPSTNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKN
|||.|.|.||.||||.||||||..|.||||||||||||||||.|||||.|.|||||||||||.|||||||.|||.|...|||..|||||||||.||.||.
arsrsgnkkyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekd

KFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSW
|||||||||||||.|||||||||..|||||.|.||||||.||||||||.|..|||||||.|||.|||||||||||..||..|.|..|..||..|||||||
kfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftsw

PDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTE
||.||||.||||||.|||||..|.|.||.|||||||||||||||.|.||.|.....||||||..||.|.|.||.||||||.||.|||..|||.|||||||
PdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdte

LEVTSLETHLQKIYNKIPGTSNNGLEEEF
|.|.|||.||||.||||.||...||||||
ldvsslekhlqklynkitgtdkigleeef
0039614 (Phosphotyrosine protein) phosphatases II 214-507 9.2e-100 329.2 In-house 7-294 (297) alignment 
Range on Protein: 214-507
Range on HMM: 7-294/297.0
TNRKYPPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQatCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGV-PDSDYINASFINGYQE-KNKFI
.  ...| |.. |.  . .. |... |...||  |. ...   .. | ..|||.||||..|||||||||.|.|..|| .||||||||...||   ..|||
allesipiplsvldlllllekansktllllefeellslkpd..ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfI

AAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKEcKCAQYWPDQGCwTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmtnRKPQRLITQFHFTSWPDF
|.||| .|||.|||||.|||.. .|||.|.|.|..  |||||||. |  |||...| . .|..| .||||.....        .. | .|.|..|.|||.
atqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn......ngesrtvthfqytgwpdh

GVPFTPIGMLKFLKKVKACNPQ--YAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDT
||| ..  .|.||..|. .. .    | ..|||||||||||||.... ||.....|..|||.  |...| ||...|||. ||.|.|.||||......|
gvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
0045450 (Phosphotyrosine protein) phosphatases II 218-502 3.9e-97 320.9 In-house 6-304 (307) alignment 
Range on Protein: 218-502
Range on HMM: 6-304/307.0
YPPLPVDKLEEEINRRMADDNKLFREEFNALPACPI--QATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGV-PDSDYINASFI--------NGYQE
...... ||. .......|.. ....||. |. . .    ....|...|||.||||..||||||.||.|....|  .||||||||..        .||  
slfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydl

KNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCW-TYGNIRVSVEDVTVLVDYTVRKFCIQQVgdmTNRKPQRLITQFHF
|.||||.|||..|||.|||||.|||.. .|||.|.|.|..  |||||||| | . ||||..| . ....| .||||.....        .. | .|.||.
krkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl...dgtgesrtvthfhy

TSWPDFGVPFTPIGMLKFLKKVKACNPQ--YAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERK---VDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
|.|||.||| ..  .|.|...|.... .    | ..|||||||||||||.... ||.....| .   ||..  |...|.||...||.  ||.|.|.||||
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

HY
..
ll
subfamily_PTPRD_pd Subfamily PTPRD 219-545 4e-136 449.9 In-house 3-325 (564) alignment 
Range on Protein: 219-545
Range on HMM: 3-325/564.0
PPLPVDKLEEEINRRMADDNKLFREEFNALPACpIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKE
.|.||..|.| ...  |...  | ||.. .     | |.|||.|..||.|||| ||..|||||| |..|||...|||||||||.||......||.|||..
kpipvaelkehvaklkansdlkfeeeykkieeg.qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPla

ETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGdmtnRKPQRLITQFHFTSWPDFGVPFTPI
||..|||||.||||..||||.|.|.|... ||..|||..|  |||.. |..|. . | ||..|.| ...      .. .| ..||||||||| ||| .. 
etiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk....ssesreVrqFhFtsWPdhgvpesat

GMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL
..|....||.|.|.. || |||||||||||||||.||||||. ...|..||.|..|...|.||  ||||  ||.||..|.||    |.||.|. .|..||
slLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhl

QKIYNKIPGTSNNGLEEEFKKLT-SIKI
||. .. ..|.  ||| ||..|. . .|
qkLaeveedtemtgleleFqrLatakei
0051299 (Phosphotyrosine protein) phosphatases II 219-502 3.6e-111 366.5 In-house 3-286 (288) alignment 
Range on Protein: 219-502
Range on HMM: 3-286/288.0
PPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKE
 ...|..|.. .....|.......|||..|... .. |. ||...||.|||||..|||||||||.|....||..|||||||.|.||. |.||||.|||..
teisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlp

ETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPI
.||.|||||.||||. .|||.|.| |..  |||||||..|..|||.|.|   ...|| |||||..... .. ..  .  | .|.||.|.|||.||| .| 
ntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspe

GMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY
 .|.||..|. ....  | .||||||||||||||...| .|.....|..|||...| |.| ||..|||| .||.|.|.||||..
llldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 219-524 5.9e-103 339.5 In-house 14-313 (319) alignment 
Range on Protein: 219-524
Range on HMM: 14-313/319.0
PPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQAT-CEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPK
|..|. ...  ... . || . .. ||....  ... .  . |  ..||.|||..|||..|...| | ...|.  ||||||||..||| |.|.||||||.
pdfpayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPl

EETVNDFWRMIWEQNTATIVMVTnlkerkECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNrkpQRLITQFHFTSWPDFGVPFTP
..|..||||||||.|..|||..|      . ||.|||| ..  ....  |.|. |.   .|.||.. . . | ...   .| ||||||  ||| |||  |
dntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekd...irkitqfhflGwpdvGvpdyp

IGMLKFLKKVKACN--PQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLE
. .....|||.  .   .    |||||||||||||...|.|..||.|. |..|||| ||  .| || ..||  .|| ||| ||||..|.| ... .  . 
sdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfp

THLQKIYNK
..|..  ||
ayleelsnk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 219-535 3.8e-92 303.6 In-house 4-312 (315) alignment 
Range on Protein: 219-535
Range on HMM: 4-312/315.0
PPLPVDKLEEEINRRMADDNKLFREEFNALPACPIQAtCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKE
 |.|.|.|   . .. |  .. |.......|   ..   . | | |||.||||.||..||.|||.|  .|  |.|||.||.||.||. |...||||||. 
qpipldqlityvaqkkastkngfkqdyesipggqlhp.ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnv

ETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQgCWTYGNIRVSVEDVTVLVDYTVRKFciqqvgDMTNRKPQRLITQFHFTSWPDFGVPFTPI
..|.||||...|.. ..|||.||| |... |. .||||.   .||.| |.  .  |  .|||| .       .. ..  | . |.|.||||| |||   |
asvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl......svvfgdnirevvqlhytswpdmgvpkyti

GMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL
 .... ..||  . . .|||||||||||||||||. .||.|| ...|. .||| |. ..|..| .|||.  || |||.|||| .. ||| .       . 
plmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqry

QKIYNKIPGTSNNGLEE
. .    | | .  |.|
dsllapspdtgstllqe
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 220-538 9.3e-113 371.5 In-house 4-319 (319) alignment 
Range on Protein: 220-538
Range on HMM: 4-319/319.0
PLPVDKLEEEINRRMADDNKLFREEFNALPAcPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEE
...|..|.|....  .  ..|...||. |   . . | . |||||||.|||| |||.||..|| |....||..|||||||||.||||..||||.|.|.|.
eievqeLkerlkalastgetllekefkllke.avndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlen

TVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRkpqRLITQFHFTSWPDFGVPFTPIG
|..|||||.||... ..||.|.|.|. . |. .|||..  ..||.. | .|.   | || .||.....  .  .    | ...|..|.||| .|| .  .
tiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevet...RevkhfqyteWpdhdvPekats

MLKFLKKVKACNPQ-YAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL
.|..||...    .  .| |||||||||||||||.|.||||. .. |  .||. .|||.|.||  |||.  || |||.||||    ||||.||  |.. |
lldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrl

QKIYNKIPGTSNNGLEEEFK
... .|...| . ||| ||.
kqlaekvadtgetglerefq
subfamily_Ptp69D_pd Subfamily Ptp69D 220-521 3.3e-101 333.5 In-house 3-305 (307) alignment 
Range on Protein: 220-521
Range on HMM: 3-305/307.0
PLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEE
....|.|||... |  | . .. .|.. |.|  |. ..... |.||. |||| .| ..|. || |....|  ||||||||||.||.||.||||||.| |.
aiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPvea

TVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMT-NRKPQRLITQFHFTSWPDFGVPFTPI
|..||||||.||.  .|||..||.| .. |||.|||..    ||.| | . .     ||. |.. . .... . . . .| ..|.|.|.|.|. || .. 
tigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevar

GMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL
|.||....|.  . .  . |||||||||||.|.|| .| .|. ...| |||.. .|  .| ||  .||   ||||.|.|||..  ||||. .| .|| ..
gllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddledai

QKI
...
erl
subfamily_PTPRB_pd Subfamily PTPRB 220-501 7.8e-101 332.0 In-house 6-284 (293) alignment 
Range on Protein: 220-501
Range on HMM: 6-284/293.0
PLPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEE
|. ..|.|| ...  ||..  | ||.. | |   . ...||....|..|||| ||||||||||.|..... ..||||||..|.||. ...|||.|||  |
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ-GCWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmtnRKPQRLITQFHFTSWPDFGVPFTPI
||.|||||.||... .|||.|.| |.   || .|||..    .||.|.|..   ..| |...|.. |..      .| .| ..|.|||||||.||| .. 
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek......ekeerkvrqyhftsWpdhgvPektk

GMLKFLKKVKACN--PQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
 .|.|...|.      . .. |||||||||||||||. .| .|. ...|  ||..|.|...| .|...|||  ||.||.|..|. 
tlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 220-539 7.1e-89 292.7 In-house 2-314 (315) alignment 
Range on Protein: 220-539
Range on HMM: 2-314/315.0
PLPVDKLEEEINRRMadDNKLFREEFNALPACPIQATCeAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEE
|.|| ..   .|.       || |||. ||  .|  .  .| ...| .|||| ||||.|..|| |  ..  |||||||||.|..... . .||.|||.. 
pipvaqfpafvnknr..htalfseefhdlpdPdiyrqr.varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlka

TVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD--QGCWTYGNIRVSVEDVTVLVDYTVRKFcIqqvgdMTNRKPQRLITQFHFTSWPDFGVPFTP
.|.|||||.......||||||...|    ||.|||||       .|.|.|.. ..    | ..||. .     . . . .| .|||.|| ||| ||.   
svddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.v.....trkseesrtvtqfqftewPdkGvdkqt

IGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETH
  .||..|.||| | ..  ...||||||||||| .. || ... .. .| |||. ||  .||.| ..|||. .| |||.|.||. |. .| . |  .  |
ssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdh

LQKIYNKIPGTSNNGLEEEFKK
|| ..    |.  . . .||..
lqdlhtsvdgsgrskmtkefet
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 220-512 4.9e-81 267.1 In-house 9-294 (297) alignment 
Range on Protein: 220-512
Range on HMM: 9-294/297.0
PLPVDKLEEEINRRMadDNKLFREEFNALPACPIQATCEAaSKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEknKFIAAQGPKEE
|.|. ..   ... .  . ..|.|||. ||.  ||..  |  |  | ||.|| |||||| |||.|  |.  |||||.||||..|...  ..|. | |...
piplsdfatlvqknr..htdvfseeflclpeaniqpqtva.ekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmka

TVNDFWRMIWEQNTATIVMVTNLKERKEcKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmTNRKPQRLITQFHFTSWPDFGVPF--TP
||.|||.|.......||||.....||.. |||.||.|.|  |.|.. | .. |.    .  |.. ...     . | .|.. |..|..|||  |.   . 
tvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtk....gkakarrvvkqyqfveWPdkaverkdsa

IGMLKFLKKVKACNPQYAG-AIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVT
  .||... |.    | |   ..|||.||||||| .. || ..  .. | .||..|.|...| .| ..|||. || |.|.|.||  |  ||.....
ssllklisevrkdfsqnaegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqas
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 220-540 2e-74 245.3 In-house 3-274 (392) alignment 
Range on Protein: 220-540
Range on HMM: 3-274/392.0
PLPVDKLEEEINRRmaDDNKLFREEFNALPACPIQATcEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEE
|.|| ..   ...     . || |||  ||  .|  .  .| || |..|||| |||||| .||.|  .. .|||||.|||.|.... .. .||.|||.  
pipvaqfpafvekn..rhsalffeefhdlpgpdiypq.tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaa

TVNDFWRMIWEQNTATIVMVTNLKERKeckcaqywpdqgcwtygnirvsvedvtvlvdytvrkfciqqvgdmtNRKPQRLITQFHFTSWPDFGVPFTPIG
...|||||....|..||.|||.|||                                                . . .| ..||||| ||| .||     
slddfwrmvfqenvttiamvtklkegd..............................................kgddartvaqfhftewPdkdvpkhtss

MLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQ
.|||.|.|||   ||.  ...||||||||||  . ||...   .. | |||. ||. || .|  ||||. || ||| |.||  |. .| . |  .  |||
llkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlq

KIYNKIPGTSNNGLEEEFKKL
..     |  .     ||..|
dlstssdGdvrskqlkefrsl
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 221-540 8.5e-113 371.6 In-house 2-318 (318) alignment 
Range on Protein: 221-540
Range on HMM: 2-318/318.0
LPVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEET
..|..||. ..| ... . |. ||...|  .. ..|   . .. || ||||.|||.|||.||.|...||...||||||..|.||..|...||||.|  ||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

VNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmTNRKPQRLITQFHFTSWPDFGVPFTPIGM
..|||||.||||.|.|||.|...||   |...|||..|  .||...| ... . | ||..|.| ...    |. . .| . |.|.||||| |||  . ..
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr....teeeesrqvrqyhytsWpdegvpesgasl

LKFLKKVKACN-PQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQ
|.....|.. . .. ||.|||||||||||||.|...|..|. .. |  |||...|...| ||  ||||. ||.|||..|||    |||| . . | ....
ldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrir

KIYNKIPGTSNNGLEEEFKKL
.. .. | . .  .. ||..|
elreqdpesgttemdaefqrl
0043336 (Phosphotyrosine protein) phosphatases II 221-501 7.4e-100 329.2 In-house 2-276 (278) alignment 
Range on Protein: 221-501
Range on HMM: 2-276/278.0
LPVDKLEEEINRRMADDNKLFREEFNALPACPIqATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEET
..| .|.. ..........|...||  |. ...  |.. | ..|||.||||..|||||||||.|....|..||||||||...||. ..||||.||| .||
isvkdllkallelllnlktllllefeellsfkl.dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpet

VNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPdQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmTNRKPQRLITQFHFTSWPDFGVPFTPIGM
|.|||||.||... ||||.|.|.|.. .||||||| .| .|||...| . ....| |||||....      .  .. | .|..|...|||.||| ..  .
vedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn....lgdgesrtvthyhylgwpdhgvpeslsll

LKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
|.|||.|. ...   |...|||||||||||||.... .|.....|..||..  |...| ||...|||..||.|.|.||||.
ldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealley
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 221-503 2.6e-72 238.2 In-house 2-279 (287) alignment 
Range on Protein: 221-503
Range on HMM: 2-279/287.0
LPVDKLEEEINRRMADDNKLFREEFNALPA---CPIQATCEAASkeENKEKNRYVNILPYDHSRVHLTpvegVPDSDYINASFINGYQEKNKFIAAQGPK
.||.|. | ...  |  |. |.. |  |      . . | . ||  .||.|||. .||..|  || |       . |||||.||.||.||..||.|..| 
ipvekfgefvakghakgnegfknqftvleqvtqredevthnias..qnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPm

EETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGdmtNRKPQRLITQFHFTSWPDFG-VPFT
 .|. .||..|...|  .|||....|| .| .| ||||.. . ..|. .... . .|  .|..||. ... .   . .... ..|...|.|.. | |.  
fntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknkn...kagdkqqvkqyqitnWdstgkvtep

PIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYL
   .| . ...|.   .  ..||||||..|||...|. ..  ..  .||  .||.  . . | |. ..|||  || ||....||.  
qtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyld
subfamily_PTPRG_pd Subfamily PTPRG 222-516 1.4e-107 355.3 In-house 2-301 (563) alignment 
Range on Protein: 222-516
Range on HMM: 2-301/563.0
PVDKLEEEINRRMADDNKLFREEFNALPACPIQA--TCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDS-DYINASFINGYQEKNKFIAAQGPKE
||..... .    ||... | |||.||  . |.   ..|...|.|||.||||.||..||.|||.|.|. |. .. |||||..|.||| ...|||.||| .
pvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

ETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQ--VGDMTNRKPQRLITQFHFTSWPDFGVPFT
.|..||||||||||.|.|||.|||.||.  || .||| ..  |||...|  ..  ||. ||||.. |..  . .  ... ..|..|.|.|.||| |||  
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

PIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLET
..  |.| || .| |.. || ||||||||||||||..|.|..|  ...| .|.|.||. .|||||  .|||  ||.|...||||  . ..|||  . .| 
slpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 222-521 1.9e-89 294.8 In-house 5-302 (305) alignment 
Range on Protein: 222-521
Range on HMM: 5-302/305.0
PVDKLEEEINRRMADDNKLFREEFNALPACpiQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETV
 .|.|.. |.   ....| . .....|.    . ...  .||.||.|||...| ..|..|..||. | ..||||||||...||..|.|.|.|||| ..||
alddlaayikearvysdkgleaqykslyee..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

NDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCW--TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDmtnRKPQRLITQFHFTSWPDFGVPFTPIG
.||||.|.|  . ||||.|.|.| .. || ||||..      .|.. | ... .   ||. ||..| .  .    | .| ..|...|.||| ||| ..  
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede...dkesrtvlqyqltdWPdhGvpqfats

MLKFLKKVKACNPQYAG-AIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHL
.|...|.|.    .  | ...|||||||||||.|...| .|. ...|  |||.. . ..| .| .||||  ||||...|| |    |||.. .  |. ..
llslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlrarv

QKI
.|.
nkl
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 222-501 1.9e-76 251.7 In-house 3-282 (290) alignment 
Range on Protein: 222-501
Range on HMM: 3-282/290.0
PVDKLEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPD--SDYINASFINGYQEKNKFIAAQGPKEE
||||. | .    |  |. ||..|..| .   . | . .  ..||..||. ||..||  |. | |. | .|   .||||..|.||.||...||.||| ..
pvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsn

TVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVgdMTNrKPQRLITQFHFTSWPDFG-VPFTPI
|. |||..||..... |||.|| .| .. || |||||..  .||.... . . ..| .|. ||. ...    .. .... .||...|.|.. | |. .  
tlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknk..nsa.gakqsvtqyqitnwdstgkvtnpqt

GMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
 .| . . .|    .  ..||||||..|||...|....  .. ..||  .||.  . . | |. ..|||  || .|.| .|. 
illvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivlty
subfamily_PTPRK_pd Subfamily PTPRK 223-538 1e-98 325.1 In-house 6-313 (314) alignment 
Range on Protein: 223-538
Range on HMM: 6-313/314.0
VDKLEEEINRRMADDNKLFREEFNALPACpiqatCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVN
|. | ..|.   . ..  |.||...|.        .|| |.||.||||. .||.||.||| |....| |.||||||..|..|.  ..||..|||..|||.
vadllqsiallkraegygfkeeyeslfeg.....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvk

DFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWtYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMtnRKPQRLITQFHFTSWPDFGVPFTPIGMLK
||||.....|.|.|||.|.|.|    || .|||...   ||.|.| . ....| .. || | ....      . .|.. ||.|..|||..||    |.||
dfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrveklarg..qeeirevrqfqflgWpdhdvPvsatgllk

FLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIY
....||. ... || |||||||| ||||||..|| .|||...|. |||.  |  .|...  ||.|  ||.|||...||  | |.| . |. ...   .. 
lvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalylesi

NKIPGTSNNGLEEEFK
.  | |    |.|||.
rldpqtnssqlkeefq
subfamily_PTPN14_pd Subfamily PTPN14 223-500 7.5e-64 210.6 In-house 9-294 (300) alignment 
Range on Protein: 223-500
Range on HMM: 9-294/300.0
VDKLEEEINRRMAdDNKLFReEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVpDSDYINASFINGY--QEKNKFIAAQGPKEET
 ||. . .....  . |.|  |.. .|    .|....|. .||.||||. ..|||...||.|.| .   ...||||| |.     .. ..|.|||| | |
kdkrakilekkle.egkvft.eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPlelt

VNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ----GCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVgdmtNRKPQRLITQFHFTSWPDFGVPFT
|.|||.|.|||... |||.|. .|    |. .|.|..       ..|. .|. . ..    .. ... .. .      | .| .  . .| ||| |||  
vqdfWqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl....pskeertvwhlqytDWpdhgvPeD

PIGMLKFLKKVKACNPQYA---------GAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
. |.|..|..|..   .             ..|||||||||||  .. | ..  .......|.   ..|.| ||  .|||  || |.|..|..
vkgflsyLeevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlik
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 224-538 1.2e-83 275.9 In-house 8-324 (325) alignment 
Range on Protein: 224-538
Range on HMM: 8-324/325.0
DKLEEEINRRMADDNKLFREEFNALPACPIQATcEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVND
 .| | .... |.|.  |  ||. ||.   .|  ..| | |||.|||. |....|.||| |   .  |.|||||||... ...|. |.||| |. .|.||
vnlvehvekkkaqdqdgfahefgllpsddgiak.kvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatind

FWRMI--WEqntATIVMVTNLKERKECKCAQYWPDQ--GCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTnrkpQRLITQFHFTSWPDFGVPFTPIG
.||..  |.   ...|.|.|  . .. .||.|||..     |.| ..|..  .  . ||  |.. ..|| .       | . ||.. ||.|.||.  |  
lWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGe....trsvkqfqlqswddmGvqkrpat

MLKFLKKVKAC------NPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTS
.. .|. |||       | . .. |.|||||||||||.|. . ..|. . .| .||..||| ..|..| .||.|  ||..||.|| | |. |.|.. |.|
lisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvss

LETHLQKIYNKIPGTSNNGLEEEFK
.|..|  . .. | | .  .|.||.
feaklsslqernpltqklniekefe
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 224-516 2.4e-77 255.3 In-house 5-293 (439) alignment 
Range on Protein: 224-516
Range on HMM: 5-293/439.0
DKLEEEINRRMADDNKLFREEFNALPACPIQATCEA--ASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETV
|...| ...   .....|.|.|. . .   . .|.|  |..| .. |||| .. ..||.|| |  . ||| | |||| .|.|| ... .||.||||.||.
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkett

NDFWRMIWEQNTATIVMVTNLKERKEckcaqYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRkpQRLITQFHFTSWPDFGVPFTPIGML
.||||...|..|.||||.||| |        ||| ..   ||.| | |.    | .|..| | . .  | |..  .| . |||...|||  ||     .|
ddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttek..ertvlqfhyiawpdknvpaqashvl

KFLKKVKACNP-QYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLET
.||. ....|  .  | .||||||||||||| . .|  |. ...| |||. | |. .| || ||||.  ||||||.|.||   |||. . .  .. 
dflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk
0040438 (Phosphotyrosine protein) phosphatases II 226-541 1.1e-108 358.6 In-house 5-315 (317) alignment 
Range on Protein: 226-541
Range on HMM: 5-315/317.0
LEEEINRRMADDNKLFREEFNALPACPIQaTCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFW
|.. ...... |.....|||. |. ...  |.. |...|||.||||..|||||||||.|.|..|..||||||||...|...|.||||.|||...||.|||
lllalldllksdftalleefedllslkld.tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFw

RMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLK
||.|||.. .|||.|.|.|..  |||||||... .|||...| . ....| ..|.|.....      . ...| .|.||.|.|||.||| .|  .|.||.
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl....gdsesrtvthfhytgWpdhgvppspdllldfle

KVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKI
.|......  | ..|||||||||||||.... ||.....|..|||.  | ..|.||...||| .||.|.|.||||......|  ....| ..|.|.....
avrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkllipl

PGTSNNGLEEEFKKLT
....  . |.|.| |.
alddvklkekelklll
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 226-500 6.4e-84 276.4 In-house 2-274 (281) alignment 
Range on Protein: 226-500
Range on HMM: 2-274/281.0
LEEEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFW
|....... ..||. | ||...| |  .. | .|. ..||..||||.||  ||..||..|| |   ..|||||.|..||......||.|||  .....||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMIWEQNTATIVMVTNLKERKECKCAQYWPDQG-CWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFL
.|.|||.  .|||||.  |    || .||||.    .||...|. .  .    |  ||| ...     .  ..| ..|...|.||| ||| |.  .|.| 
qmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkler.....esgetreveqlaytaWPdhGvPattkellefr

KKV-KACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTE-RKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
|.| |. ...   ..|.|||||||||||.. .| ... ...| ...||   |  .| .|  |||| .|| |.|.|.|.
kevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavld
subfamily_PTPN23_pd Subfamily PTPN23 226-501 2.1e-64 212.1 In-house 2-279 (288) alignment 
Range on Protein: 226-501
Range on HMM: 2-279/288.0
LEEEINRRMADDNKLFREEFNALPACPIQATC--EAASKEENKEKNRYVNILPYDHSRVHLTpvegVPDSDYINASFINGYQEK-NKFIAAQGPKEETVN
|.||..|.| |..  . ..|. |     . .     |  . . ||||. .||||||.||.|         |||||||...      .|||.|.|...|.|
lveelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstln

DFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQG--CWTYGNIRVSVEDVTVLVDYTVRKFCIQqvgdMTNRKPQRLITQFHFTSWPDFGVPFTPIGM
|||.|..|| . .|||... .|... |...||| .     ..|...|....|. .  .  |.. ..    . . .  . ..  ..||||..||| .|  .
DFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkle....tldadavksvshlqltsWpelGvPasPetl

LKFLKKVKAC----NPQYAGAIVVHCSAGVGRTGTFVVIDAMLD-MMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
|.||..|...    . .    .||||||||||||.| .. | .  . . .  .|.   |||.|.||  |||.  |. | |.| ||.
lqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 227-306 9.8e-09 29.2 In-house 3-79 (244) alignment 
Range on Protein: 227-306
Range on HMM: 3-79/244.0
EEEINRrmADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEgVPDSDYINASFINGYQE
| |..|   .|... .||| .|     .     |    |  ||||.||||.|..|| |.  .    ||||||..|.| |.
eyevsr..lqdeevakeefvglsdhtreflqtnavlsanatknryinilpfdetrvilsssk.kegsdyinanyiqgsqn
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 228-500 2e-95 314.1 In-house 10-277 (288) alignment 
Range on Protein: 228-500
Range on HMM: 10-277/288.0
EEINRRMADDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRM
. ...  |.... | ||.|.|.|   . . .|... .|..|||| ||||||. ||.|. .| ....||||||.|.|...|.|.||.|||  .||||||..
akvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWel

IWEQNTATIVMVTNLKERKECKCAQYWPDQGC-WTYGNIRVSVEDVTVLVDYTVRKFCIQqvgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKK
..|..| ||||.|.| |. . || .||||..    ||.. | . ..  | |...||. ..       .| .. |||.....||| |||     .|..|..
vyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle......kkkteleitqyqylaWpdhgvPeskapllellrq

VKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
||  |.. .| |.|||||||||||||...||..|....| ..|| |.|...| || ..|||  ||.|||..||.
vkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_PTPN6_pd Subfamily PTPN6 229-503 1e-85 282.5 In-house 15-297 (306) alignment 
Range on Protein: 229-503
Range on HMM: 15-297/306.0
EINRRMAD-DNKLFREEFNALP--ACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTpVEGVPDSDYINASFINGYQ--EKNKFIAAQGPKEETVND
|...   . ... | |||..|   ..  . . . ..| |||||||| ||||.||.|| |.  ..||.||||||..|.. .  .....||.||  |.||.|
elekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsd

FWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCW-TYGNIRVSVEDVTVLVDYTVRKFCIQQVgdmTNRKPQRLITQFHFTSWPDFGVPFTPIGMLK
||||.|..|.  |||.|.  || . |||.||||.    .||.|.|.  . . | ||..|.. ....   .. | .| . |.||.|||| |||  |  .|.
FWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk...kkkkeerevfqyhfksWPdhgvpkdpgavLd

FLKKVKACNPQYA----GAIVVHCSAGVGRTGTFVVIDAMLDMMHT---ERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALlEHYL
||..|.. . . .    |.||||||||.||||||.|||..|.....   . ..|.. .|  .|.|| ..|||. || |.|.|. ..|.
fledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykai.kkyi
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 235-514 4.5e-68 224.2 In-house 5-278 (283) alignment 
Range on Protein: 235-514
Range on HMM: 5-278/283.0
ADDNKLFREEFNALPACPIQATCEAAskEENKEKNRYVNILPYDHSRVHLTPVEGvpdsDYINASFIN---GYQEKNKFIAAQGPKEETVNDFWRMIWEQ
...|||||| .. |   . .|....|  .|||.|||. .|.|.|  ||.| .       |||||.||     |....|.|.||.| ..|| |||.|....
vnnnklfrevlkrlsvpdldadiasa..denkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfde

NTATIVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVgdmTNRKPQRLITQFHFTSWPDFGvPFTPIGML-KFLKKVKAC
. ..|||.|.|.| .. ||.|||| .|   ||.  |.... |    ...... ...    .  | . |.. . .  | ..| . ..|  | || | .   
kitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn...ssakstlllahyqvidWleyg.eqaiinslvkfnkvislq

NPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSL
. .  | ||||||.|.|||..|. . | .. . ||  |||.  |  .| ||  .|||  || ..... ||. | |||..    |
teskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdl
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 235-503 1e-22 75.1 In-house 18-280 (303) alignment 
Range on Protein: 235-503
Range on HMM: 18-280/303.0
ADDNKLFREEFNALPACpIQATCEAASKEENKEKNRYVNILPYDHSRVHLTpvegvpDSDYINASFINGyQEKNKFIAAQGPKEETVNDFWRMIWEQNTA
 .| ..  .||. . .  .  .       .| .|||.|...  |||.|.|.      || || ||...  . ..| | .| |   |  |||.|| ||.  
dedaniavnefekvvsy.lppsvsknqfvknmdknrfvdvicldhskvkls......dssyihasylel.dsskkailtqlplshtaadfwqmiieqkvk

TIVMVTNLKERKECKCAQYWPD-QGCWTYGNIRVSVEDVTvlvDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFT-PIGMLKFLKKVKACNP
 ....    | ..      .|  |    . .  . | .        . .    .|  ..| . . ..   |. .||   .|      ..| . ....   
cvlllltdseydklggdsvfprnqdflkfeersirvgefk...rvelgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlr

QYAGA--IVVHCSAGVGRTGTFVVIDAMLDMMHTER-KVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYL
.|. .   |    .|.||.||| ....    .|.|.  .|.   .  .|  | . ||   |. ..|  | || |
kysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 235-315 2.5e-17 56.8 In-house 19-95 (95) alignment 
Range on Protein: 235-315
Range on HMM: 19-95/95.0
ADDNKLFREEFNALPACPiQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEgvpDSDYINASFINGYQEKNKFIAAQG
.. .. | .||....     |.  . | | |  |||..||.||| .|| ||      ||||||| |..||  || .|||||
snsdqefdnefksismts.gapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
0036941 (Phosphotyrosine protein) phosphatases II 236-511 1.5e-99 328.3 In-house 10-286 (297) alignment 
Range on Protein: 236-511
Range on HMM: 10-286/297.0
DDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLtpveGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT
... |...||  |. . .. ....|...||.||||| .||||||.||.|    . ..|||||||...||. |.||||.|||...||.|||||.||||. .
lflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

IVMVTNLKERKECKCAQYWPDQ--GCWTYGNIRVSVEDVTV--LVDYTVRKFCIQQVgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACN
|||.|.| |.   |||||||.   . .|||...| . .|.|  | |||.|..... .    . ...| .|.||.|.|||.||| .|  .|.|...|. ..
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt....gngesrtvthfhytgwpdhgvpespaslldfielvrkvl

PQ--YAGAIVVHCSAGVGRTGTFVVIDAMLDMMH---TERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEV
..    | ..|||||||||.|||...| ||....   .|..||.. .|  .| ||...||| .||.|.|.||||......| ...
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepl
0047943 (Phosphotyrosine protein) phosphatases II 236-501 6.1e-99 326.2 In-house 9-271 (273) alignment 
Range on Protein: 236-501
Range on HMM: 9-271/273.0
DDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLtpveGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT
....|..|||..|. .... |...|...|||.|||| .|||||||||.|    | ..|||||||...||. |.||||.|||...||.|||||.||||. .
lgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrv

IVMVTNLKERKECKCAQYWPDQG---CWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGdmtnRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNP
|||.|.| |..  |||||||. |    .|||...| . ....  |||||..... .|     .  | .|.||.|.|||.||| ..  .|.|...|. .. 
iVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg....tgesrtvthfhytgwpdhgvppslesllefielvrkale

Q--YAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
.    | .||||||||||||||...| .||....|..|||.  | ..| ||. ||||  ||.|.|.||||.
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
0045098 (Phosphotyrosine protein) phosphatases II 236-506 8.1e-92 302.8 In-house 4-276 (278) alignment 
Range on Protein: 236-506
Range on HMM: 4-276/278.0
DDNKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHltpvegvpdsDYINASFINGYqeKNKFIAAQGPKEETVNDFWRMIWEQNTAT
...  .. ||  |....|  ... | ...|..||||..|||||||||.          ||||||.|.||  ..||||.|||...||.|||||.||... .
lasldlllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitv

IVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTP--IGMLKFLKKVKACNPQ
|||.|.|.|.. .|||||||..|..|||...| .....|| |||.|.. .. .  . .  ..| .|..|...|||.||| .|    .|..|. ..... .
ivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkl

-------------YAGAIVVHCSAGVGRTGTFVVIDAMLDMMhtERKVDVYGFVSRIRAQRCQ-MVQTDMQYVFIYQALLEHYLYGD
               | ..||||||||||||.|... ||...  |..||..  |. .| ||.. .||. .||.|.|..|||..|.|.
laslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrgk
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 236-545 6.4e-91 300.0 In-house 15-319 (515) alignment 
Range on Protein: 236-545
Range on HMM: 15-319/515.0
DDNKLFREEFNALPACPIQATCeAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT
    || |||. ||   |      | .| | .|||| |||||| .|| |  ..  |.|||.|||.|....  . .||.|||.. .|.||||.....|..|
rhttlfseefhdlpgpniypqt.vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvtt

IVMVTNLKERKECKCAQYWPD--QGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmtNRKpQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQ
|.|||.|||    ||..||||       .|.|.|..  .    . . ||. . .     . .  | .|||||| ||| |||     .||..|.||| . |
iamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlk.....gdd.srtvtqfhfteWPdkGvpkhtssllklikevkadhgq

YAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGL
|. ....|||||||||| .. || ..  ..| | |||. ||  ||..| ..|||. || |||.|.||. |. .| . |  .  ||| ..    |     .
ythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskm

EEEFKKLTSIKI
 .||. | |.  
tkefqtlkslcp
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 236-500 9.2e-60 196.9 In-house 13-291 (301) alignment 
Range on Protein: 236-500
Range on HMM: 13-291/301.0
DDNKlFREEFNALPAcPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEG--VPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNT
  || | |....|     . .|.   .||||. ||. || .||. |. |.| .   .   .|||||.|.||.||.|||||||| ..|. ||||.||.. .
hsnk.feeqykelke.gedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekp

ATIVMVTNLKERKECKCAQYWPDQG--CWTYGNIRVSVEDVTVLVDYTVRKFCI--QQVGD---------MTNRKPQRLITQFHFTSWPDFGVPFTPIGM
..|||||||||... || ||||.      ..|.. | . . .|. |...|....  |.. .         ....|  . ..|.. |.||. ||   |  .
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

LKFLKKVK-ACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
|. . .|  . .    | .|||||..|.|.|... ..  |.    |  |||.. . ..| ..  .|.|  ||..||... .
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidm
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 236-502 5.4e-46 151.7 In-house 3-259 (267) alignment 
Range on Protein: 236-502
Range on HMM: 3-259/267.0
DDNKLFREEFNALPA-CPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEgvpdSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTA
|... ...||. .    ....|.     |.|.|.||. . ||||..|| |   |     .|||||...||. ||.||. |.| . |. ||. .| .|. .
deeceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtke....eeyinasyvegyktknafivtqdplkntitdfltvihdqkvp

TIVMVTNLKERkecKCAQYWPDQ--GCWTYGNIRVSVEDVTVLVDYTVRKFCIQqvgdMTNrKPQRLITQFHFTSWPdFGVPFTPigMLKFLKKVKACNP
.||..|.  .    .  ..|| .   .  | .. |         || .  . ..    . | .  . .| ...  |    .   |   || |  . | | 
vivlltkvftd...nirlfwPPkmgqakkyqdltvehslekeendyqiitlelk....fkn.esahnvtlyyykkwn.intnnkp..ylkplfgilaknq

QYAG--AIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY
   |   .||.||.||||.|||.|||..|. . ||  .|.. |. .|| ||  .|.|  .|..|.. | |. 
lengnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeya
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 236-500 1.6e-25 84.2 In-house 22-283 (302) alignment 
Range on Protein: 236-500
Range on HMM: 22-283/302.0
D-DNKLFREEFNALPACPIQAT-CEAAskEENKEKNRYVNILPYDHSRVHLTpveGVPDsDYINASFINGYQEKNKFIAAQGPKEETV---NDFWRMIWE
  |.   ..||... .  ...  |.|    .| .||.  ..  .|. .| |.   . || .|.||| ..  . ... | || || ...   ..||||...
sldtaevkkefkkidtmkvdlekCkaf..kknlkknqsedvpildsnlvkle...aepd.syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfq

QNTATIVMVTNLKERKEcKCAQYWP-DQGCW-TYGNIRVSVEDVTVLVDYTvRKFCIQQVGDMTNRKPqrLITQFHFTSWPDFGVPFTPIGMLKFLKKVK
.. ...|..   .| |.    ...|  .| . .||...| .  |   .. .  ...|  . .     .  |..  ..| |..  ||     . |  .|| 
ekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsv..lanvyvltnWkqkkvpvkyaeliktaakvf

ACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
| . .    .|.    |.|| |.|..  . .. .... .. .   |  ||.||...|..  |||..| ||| 
akkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialll
subfamily_PTPN9_pd Subfamily PTPN9 238-504 2e-80 265.0 In-house 15-292 (297) alignment 
Range on Protein: 238-504
Range on HMM: 15-292/297.0
NKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIV
..  ..|. .. . |.. | .|. .  | ||||| ..| ||..||.|. |.. . ||||||.|..||..|. |||.||| ..||.|||||.|||.. .||
krGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlviv

MVTNLKERKECKCAQYWP--DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACN---P
|.| . ||.  ||.||||  .. .  .|...||. .| .  ||.||.. |..|    . . .| .| | |.||||.||| .   .|..|.||.       
mttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknv....kteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalav

QYA----------GAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLY
..             ||||||||.||||||. .|  |. .... .|||   |...|.||  ..||. ||.| |.|.||. |.
kelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyale
subfamily_PTPN13_pd Subfamily PTPN13 238-500 2.8e-73 241.5 In-house 10-267 (273) alignment 
Range on Protein: 238-500
Range on HMM: 10-267/273.0
NKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGvpdsdYINASFINGYQEKNK--FIAAQGPKEETVNDFWRMIWEQNTAT
..   |||. |     . ||| . |.|||.|||| |.||||..||.|    |     |||||.|.   .|..  .||.|||  |||.|||.|.|||..  
qqqPaeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaev

IVMVTNLKERKECKCAQYWPDQG---CWTYGNIRVSVEDVTVLVDYTVRKFCIQqvgDMTNRKpQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNP
|.|||. ||... || .|||..       .. ..|....|. | ...||.. ..   |.  ..  | .....|..||| ||| ..  .|.|...|.  . 
iamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavk...dsesge.srevahlnfvkwPdhgvPssaaellqfvaevrrlqt

qYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
  || ||||||||.||.||...||..|.... ....||   | ..| ||  .|||. ||.|.|.|.||
.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_CG7180_pd Subfamily CG7180 238-505 3.5e-68 224.4 In-house 16-293 (296) alignment 
Range on Protein: 238-505
Range on HMM: 16-293/296.0
NKLFREEFNALPACPIqATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIV
. ... |..  |   |  .| .. ..||.||||.|...|||. || |. ..|  .||||||......  |...|  ..||.|||..|||....... ..|
rveyklelkltprlei.gdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavv

MVTNLKERKEcKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQV----GD--MTNRKPQRLITQFHFTSWPD-FGVPFTPIGMLKFLKKVKAC
..|.  . .. .. .||| ..   ||.| | .  .  . . . |.| ...     ..       ..|....|..| |.    ||.   ........|.  
vLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlw

NPQY-----AGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYG
  .       | .||..| |..|.| .. ||| |.... | .|||...| ..| .| |.|..  .| .||. |||..| .
rekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_PTPRN_pd Subfamily PTPRN 238-500 2.5e-65 215.1 In-house 29-290 (297) alignment 
Range on Protein: 238-500
Range on HMM: 29-290/297.0
NKLfREEFNALPACPIQ-ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKN-KFIAAQGPKEETVNDFWRMIWEQNTAT
..| ..|..|| |   . .|.|.|..|.| .|||. ..||||||||.|.      .|||||||.|   . ..  .||.|||  .|| |||.|.||| .. 
drl.ekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvv

IVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDV-TVLVDYTVRKFCIQQVgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQY
||..|.|.|    .|..||||.|  .|.   | .        || || | ....    . .  | .||||| |||. ||| ..  .|.| .||  .    
ivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknl....qtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGr

AGAIVVHCSAGVGRTGTFVVIDAMLD-MMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
. .||||||.|.||||....|| .|. ...  ...|.   .  .| || ..|.|  |. |...|. |
scpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 238-501 1.8e-51 169.5 In-house 12-268 (281) alignment 
Range on Protein: 238-501
Range on HMM: 12-268/281.0
NklFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTP-VEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATI
.  |..||  ||  |    | .  .  |..||||.||   | |||.|   .     .||| | .|     |  .| .||||.||  |||||||..||..|
d..fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

VMVTNLKERKECKCAQYWPDQ--GCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDmtnrkpQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACnpqy
||. .. | .  |||.|.| .   |  . .. || || ||       .. .   |.       ||||.. .  |||. || .   ||| |.|..|     
vmlcqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyege......trlithwlwkewpdwqvpessevmlkilrkirar....

AGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERK-VDVYGFVSRIRA-QRCQMVQTDMQYVFIYQALLEH
.   |.||||||||.||.. ..  |. .|.     |.   ||..|   |.  |||  ||..|.. ||. 
stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
0049772 (Phosphotyrosine protein) phosphatases II 238-509 2.9e-51 170.4 In-house 19-287 (314) alignment 
Range on Protein: 238-509
Range on HMM: 19-287/314.0
NKLFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDhSRVHLtPVEGVPDSDYINASFINGYqekNKFIAAQGPKEETVNDF----------WRM
.||. .  .  .  .   |. .|....|..|||| .|||.| .||.| | ..| .|||||||...|.   .||||.|||.|.||.||          |||
lklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrm

I--WEQNTATIVM---------------------VTNLKERKeckcaqywpdqgcwtY----------GnirvsvedvtvlvdytvrkfciqqvgDMT--
.  ...|. .|||                      ..| ..                                                      . .  
vlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...............neptaadlellk..........................eelyd

NRKPQRLITQFHFTSWPDFGVPfTPIGMLKFLKKVKACnpQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMhterKVDVYGFVSRIRAQRC-----QMVQT
. ...||. ... . .||...| ..  ...||. ....  .  |...|||.||.||||||||.. ..  .    .|..   ....|..|       ....
pelferlgikylripvpDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieq

DMQYVFIYQALLEHYLYGDTEL
 .||.||..||||.. .  .. 
leqyefilealleylkflkkfy
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 238-304 3.4e-16 53.6 In-house 21-86 (440) alignment 
Range on Protein: 238-304
Range on HMM: 21-86/440.0
NKLFREEFNALPACpIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGY
 . | .|.. ||.  ..  .. ||  .|| |||| ||| |||||| |  |.|||||||||||.||| 
srafedewsllpsg.lsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 239-508 1.2e-96 318.5 In-house 27-296 (298) alignment 
Range on Protein: 239-508
Range on HMM: 27-296/298.0
KLFREEFNALPACPI---QATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTAT
  . .||. | .      ... |.|.|.|||.|||| .|...|.||| |. ...  .||||||||...|...| |||.|.| .|||.|||||..|.. .|
tgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigt

IVMVTNLKERKECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKAcNPQYA
|||.|||.| .. |. .||||.|  |||.|.||.    .  |..|||. ...    .... .| . |.||||||| ||| .   .|..|.||.| ..| |
iVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvsk....kkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqqa

G--AIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTE
|  ...|.|||||||.|||..||..|. ...|..|||.  | ..|..|...|||  ||||||.| ||    ...|
gnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfnde
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 239-501 2.9e-73 241.3 In-house 5-267 (274) alignment 
Range on Protein: 239-501
Range on HMM: 5-267/274.0
KLFREEFNALPACPiqaTCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGV-PDSDYINASFINGYQEKNK-FIAAQGPKEETVNDFWRMIWEQNTATI
| ...||  ||.     . |  .   ...|||| .||| ..||| |.. ..  .||.|||| .| ||.|..| ..|.|||  .||.||||||.....  |
kdlekeflelPlnf...dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvi

VMVTNLKERKECKCAQYWPDQGCW----TYGNIRVSVEDVTVLVDYTVRKFCIQQVGDmtN-RkpqrlITQFHFTSWPDFGVPFTPIGMLKFLKKVKACN
||.|.|||..| |||.|.||.       .||.. . ||...   ||.|||. .... .  . .     .. . .|.|||  .|  .  .|.....|.  .
vmltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ers.....vkhywytdWPdhksPddantlldlvleveesr

PQ---YAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
 .    ....|||||||.|||| |. |.  .  .. | .||| . |. .| .|  ||||. || .|..|| ..
eeenaklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcly
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 240-503 1.2e-41 137.5 In-house 23-288 (305) alignment 
Range on Protein: 240-503
Range on HMM: 23-288/305.0
LFREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLtpvEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMV
 .|.||.|.         .|  . ....|||| ..   |. ||.|   ||    .|| | ..    . ..|| .| | |.|  ||| | ....  .| |.
glraefvamkrfndfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifml

TNLKERKECKCAQYWPDQGCW----TYGNIRVSVE-DVTVLVDYTVR-KFCIQQvGDMT---NRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKAC
 ||.|.   ||..|.. .         .. ..||  . .| ....   |  ...   ..     . .| .|..|.  ||| ||| . . .|..|.| .. 
cnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvte.tvlviegpgekarkvthyhwidwpdrgvpaadlailellekarps

NpqyaGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVD-VYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYL
     | ||||||||.||||. |... .|| . . ....     . .|| || . .||| ||.|..| .|....
k....gpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
0046845 (Phosphotyrosine protein) phosphatases II 241-509 3.4e-100 330.3 In-house 2-281 (284) alignment 
Range on Protein: 241-509
Range on HMM: 2-281/284.0
FREEFNALPACPIQA--TCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGV-PDSDYINASFINGY-----QEKNKFIAAQGPKEETVNDFWRMIWEQN
..||| .|. . .    ....| ..||..||||..|||||||||.|....|  .||||||||...||       |.||||.|||...||.|||||.||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

TATIVMVTNLKERKECKCAQYWPDQG-CWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDmtnRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACN
. .|||.|.| |..  |||||||. | ..|||...| . ...|  |||||..... .|     .. | .|.||.|||||.||| .|  .|.||..|. ..
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy...tgesrtvthfhytswpdhgvppspedlleflrlvrell

P--QYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTER---KVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTEL
.   . | |||||||||||||||...| .|.....|.   .|||.. |.|.| ||..|||| .||.|.|.||||..... | |
enlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
DSPc_SM00195 241-501 2.3e-92 304.4 In-house 2-261 (263) alignment 
Range on Protein: 241-501
Range on HMM: 2-261/263.0
FREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVT
..|||. | .   . ... | |..||.|||| |||||||.||.|.. |. ..||||||..|.|...|.|.||.|||...||.|||||.||... .|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLKERKECKCAQYWPDQ--GCWTYGNIRVSVEDVTVLV-DYTVRKFCIQQVGDmtnrKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA
. .|... ||..|||..  | .|.|.|.| . .|.    ....|.. ... |.    . .| .||.....||| ||| ..  .|..|..|| .. .  | 
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk....eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

IVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
||||||||||||||||.|| .|. ...| |||.   |...| ||..||||..|| |||.|.|| 
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 241-501 2.3e-92 304.4 In-house 2-261 (263) alignment 
Range on Protein: 241-501
Range on HMM: 2-261/263.0
FREEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVT
..|||. | .   . ... | |..||.|||| |||||||.||.|.. |. ..||||||..|.|...|.|.||.|||...||.|||||.||... .|||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLKERKECKCAQYWPDQ--GCWTYGNIRVSVEDVTVLV-DYTVRKFCIQQVGDmtnrKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGA
. .|... ||..|||..  | .|.|.|.| . .|.    ....|.. ... |.    . .| .||.....||| ||| ..  .|..|..|| .. .  | 
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk....eetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgp

IVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
||||||||||||||||.|| .|. ...| |||.   |...| ||..||||..|| |||.|.|| 
ivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 241-505 1.1e-46 154.3 In-house 18-280 (307) alignment 
Range on Protein: 241-505
Range on HMM: 18-280/307.0
FREEFNALPAC-PIQATCEAASkeENKEKNRYVNILPYDHSRVHLTpVEGVpDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMV
...||. |    |   | || |   | .|||| ..   |..|. .. ..|.  |||| | ..    . .|||.||||.|.|. .|| |. ...  ...|.
lvdefrvlakktpegvtveafs..antdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

TNLKERKECKCAQYWPDQGC--WTYGNI--RVSVEDVTVLVdYTVRKFCIQ-QVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKAcnpQy
 .. |  . || |||| .     ..|.    .||... .    .  . .|.    ..   .  | |... .. ||| ||| . .. . .|. |.    . 
ckvielakikceqywpleegqklvfgeapntisvanlgakk.lapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry...d.

AGAIVVHCSAGVGRTGTFVVIDAMLD-MMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYG
   .||||||||||.|| | |  . | |.  .   |.  .|  .|.||   .||..||..... |||..|  
tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflel
subfamily_ptpA1_pd Subfamily ptpA1 242-461 5.5e-39 129.1 In-house 24-255 (418) alignment 
Range on Protein: 242-461
Range on HMM: 24-255/418.0
REEFNALPACPIQATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKnKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTN
.|||  |      .      |. |  |||| |||| .|.||.|  ..    |||||| .|.|   | .||..|||  .|. |||||.||.    |||.. 
keefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk.qfictqgplpntiadfwrmvwenrcriivmlsr

LKERKECKCAQYWPDQGC----WTYGNI-----RVSVEDVTVLVDYTvRKFcIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNP
  |    || .|||.|        |||        ||| | |. |   |.  | .   .|     | |||...  |||. .|     . ..|. .   . 
esencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpe.rei.itrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

QY------AGAIVVHCSAGVGRTGTFVVIDAMLDM
|          |.|||||||||||||.    |.  
qiipssdrnvpiivhcsagvgrtgtfctavimmkk
subfamily_CG42327_pd Subfamily CG42327 242-430 1.6e-32 107.5 In-house 8-193 (319) alignment 
Range on Protein: 242-430
Range on HMM: 8-193/319.0
REEFNALPacPIQATCEaASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQE-KNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVT
 |||. ||   . | .. .     |.|.|..|..|  ..|| |  .   . . |..||.. ||.. .| .|||| . |..  ||||..|||.. .|| .|
aeefrdlP..qliarad.evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqlt

NLKERKECKCAQYWPDQ----GCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKpqrlITQFHFtSWPDFGVPFTPIGMLKFLKKVKAC
.| |    .||.|.| .    .  .||.|.|.. .  |   | .  . ...| .   |.    .| . .  |.. .||  .  ..  | .|.. 
dlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesre....lthywy.kwleaevPaeeaaliamllevrss
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 244-524 1.8e-98 324.6 In-house 3-277 (284) alignment 
Range on Protein: 244-524
Range on HMM: 3-277/284.0
EFNALPACPIQA-TCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTnl
||....  .... . . |  ..||.|||...||..|...| | .. |.  |||||||||.||| |.|.||.|||...|..||||||||.|..|||..|  
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt..

kerkECKCAQYWPDQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNrkpQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACN--PQYAGAIVV
    . ||.|||| ..  .... .|.|. |.   .|.||.. . . | ...   .| |.||||  ||| |||  |. .....|||.  .   .    |||
....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekd...irkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivv

HCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELEVTSLETHLQKIYNK
||||||||||...|.|..||.|. |..|||| ||  .| || ..||  .|| ||| ||||..|.| ... .  . ..|..  ||
hcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleelsnk
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 244-524 1.3e-31 104.5 In-house 24-298 (312) alignment 
Range on Protein: 244-524
Range on HMM: 24-298/312.0
EFNALPACPIQATCEAASKeeNKEKNRYVNILPYDHSRVHLTPVEGVpdsdYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLK
|..|.     .. | |  |   |. ||| ||  .|  |  |.  |      || | |..     ..|...||| |.|.  ||..     ...|.... . 
eykavgnivsdsectaflk..fkdlnrypniqcwdrgrftlagdenf....yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfv

ERKECKCAQYWPDQ-GCWTYGNIRVSVEDVTVLVDYTV-----RKFCIQQVGDMTNRKpqRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNpqyaGA
|    |||.|  |  |     . ||  | .| .           .  .. |   | ..    . .. ..|||| |.| .    |..|  ||  .      
edgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqe..sklnhyqwaswpdhgmpdscdtalrllsavkkdk....kp

IVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEhYLYGDTELEVTSLE-THLQKIYNK
.. |||||||||||...|..|.  .   || .|      .| .|.. |..  |||.  ...|| .||  .  .    | |.... | |
viahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvle.flyskglykrneqewtkfketyak
subfamily_PTPN3_pd Subfamily PTPN3 254-502 8.3e-68 223.3 In-house 30-275 (280) alignment 
Range on Protein: 254-502
Range on HMM: 30-275/280.0
QATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEgvpdSDYINASFIN----GYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECK
. ...|| | || .|||| .|||||. ||.|.  |    .|||||...|    . .  |..||.||| ..|..|||.|.|||.. .|||.|.| ||   |
glaisaarkpenlsknryrdilpydatrvklkese....tdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

CAQYWPDQG-CWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGR
| ||||...  ..||...| .|       | .|......    .. | .| |.|. ...||| |||  .  .|.|...|...       .|||||||.||
ChqyWPetedeleygefsvkcekedetksyvlrelvlkd....ketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigr

TGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY
|| .....  | .. ....| .   |...| ||  .|||  || |. .|.|. |
tGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvy
subfamily_PTPN1_pd Subfamily PTPN1 254-509 4.2e-65 214.3 In-house 21-280 (290) alignment 
Range on Protein: 254-509
Range on HMM: 21-280/290.0
QATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGvpdsDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQY
. ....| ..||...||| .. ||||||..|   .     ||||||...  . | ..| .|||  .||. ||.|.|||.. ..||. .. |... |||||
dfptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqy

WP-DQ--GCWTYGNIRVSVEDVTV--LVDYTVRKFCIQQvgdmTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKA--CNPQYAGAIVVHCSAGV
|| ..   . .. .....|. ..      ||||.. ...     . .  | |..||.|.||||||| .|  .|||| ||.   .  .  |  |.|||||.
wPqgeeekellledtklkvkliseerksyytvrllelen....lktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGi

GRTGTFVVIDAMLDMMHTERK---VDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE--HYLYGDTEL
||.|||...|..|  .. . .   ||.   .  .| .|  ..||  |  | |.|.||  . . ||. .
GrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvikgdssv
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 254-502 9.2e-58 190.3 In-house 27-277 (287) alignment 
Range on Protein: 254-502
Range on HMM: 27-277/287.0
QATCEAASKEENKEKNRYVNILPYDHSRVHLTpVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQY
 ||  || .  . .|||| ..||.|..|| |.  ||   |||||| .. .|.....|||||||   ||.||||...|...|.....|   |    || .|
tatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcyky

WPDQGC-WTYGNIRVSVEDVTVL-VDYTVRKFCIQQVgdmTNrKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKV-----KACNPQYAGAIVVHCSAGV
||..      |   | . | ...  .|.|| . . ..      .  |.. |... |||| ... | .|...|  .|      | . . .| .|||...|.
wPerevPmrvGGysvvlldydikePeygvralrlidl...et.rearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGi

GRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY
||.|... . ......    .|||   | |.| .|  .||. .|. ..|.||  .|
GrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyy
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 255-512 4.6e-36 119.2 In-house 25-279 (285) alignment 
Range on Protein: 255-512
Range on HMM: 25-279/285.0
ATCEAASKEENKEKNRYVNILPYDHSRVHLTpvegVPDSDYINASFING-YQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQY
  |  .. | | . ||| ..   . .|| |       | ||| ||..    .... .|..|||  ||..|||.||.... | ..|.  | |    ||| |
pnctytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WPDQG--CWTYGNIRVSVEDVT--VLVDYTVRKFCIQQVGDMTNrKPQrLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAgAIVVHCSAGVGRT
.|..      .|.  ... ..    .    .  . . .  | .. .|   . . .   |||   |     |... | ||  ||.    |.||||||||||
ypeklgevvkfgkyeitlteckeeaiagtilnaltvintedass.epl.ymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrt

GTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEhYLYGDTELEVT
 ||| ||     .  . ....   |  .|| | | ||. ||..|.|  |.| |. |.  .| |
atfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlme.yfigegvvert
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 255-339 2.1e-09 31.3 In-house 27-116 (347) alignment 
Range on Protein: 255-339
Range on HMM: 27-116/347.0
ATCEAASKEENKEKNRYVNILPYDHSRVHLTPVEG-----VPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMV
. . ..  | . .|||  .    | .|| |.| .       .   ||||| |.  . ....| .| |  .|| |||.|.   . . .| .
skftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
0040439 (Phosphotyrosine protein) phosphatases II 256-502 5.2e-90 296.6 In-house 2-246 (249) alignment 
Range on Protein: 256-502
Range on HMM: 2-246/249.0
TCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWP
... |...|||.||||..|||||||||.|....|...|||||||.|.||. |..|||.||| .|||.|||||.||..  .|||.|.|.|.. .|||||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

DQGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQ--YAGAIVVHCSAGVGRTGTFV
..| ..||...| . .|.|. |||||..... .      .. | ......|.|||.||| ..  .|.|...|. .. .    | ..|||||||||||||.
lggsleygdftvtllsvevkddytvrtleltnl....ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfi

VIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHY
... ||.....|..||..  |. .| ||...||.. ||.|.|.||||..
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPN12_pd Subfamily PTPN12 256-500 6e-77 253.4 In-house 31-275 (290) alignment 
Range on Protein: 256-500
Range on HMM: 31-275/290.0
TCEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWP
. ||..||||..|||| .|||||.|||.|.  |....||||||.||.| ..| ..||||||  .|..||||||||.|.  .||. .. | .  ||..|||
steagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgkkkCerYWp

DQG--CWTYGNIRVSVEDVTVLV-DYTVRKFCIQQVgdmtnrKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTF
..|    ..|...|..|.   .  |...| . ...       | .| ..|||.|.||| ||| ..  .|.....|.  . . .  .||||||||||||| 
eegeeelefgefevtleeekavdddflirtLkveaq......kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGrtGti

VVIDAMLDMMHTERK---VDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
..|| . .....|.    .||.  | ..| ||  .|||  ||...|.|..|
iaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavae
0042113 (Phosphotyrosine protein) phosphatases II 257-501 5.6e-88 289.7 In-house 1-242 (245) alignment 
Range on Protein: 257-501
Range on HMM: 1-242/245.0
CEAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD
.. |...|||.||||..||||||.||.|.|..| .||||||||...||. ..||||.||| .|||.|||||.||..  ||||.|.. |.. .|||||||.
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

QGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNP-QYAGAIVVHCSAGVGRTGTFVVI
.. .|||...| . ....| |||||..... .      ...| ....|...|||.||| ..  .|.||. |. .      | ..|||||||||||||...
gesltygdftvtllseehlddytvrtlevtnl....gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa

DAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
. ||.....|..|...  | ..| ||...|||. ||.|.|.||||.
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
0037934 (Phosphotyrosine protein) phosphatases II 257-501 6.1e-80 263.5 In-house 2-241 (243) alignment 
Range on Protein: 257-501
Range on HMM: 2-241/243.0
CEAASKEENKEKNRYVNILPYDHSRVHLtpvegvPDSDYINASFINGYqekNKFIAAQGPKEETVND----FWRMIWEQNTATIVMVTNLKERKECKCAQ
.  |...||..|||| .|||||||||.|      ..||||||..|...   ...|| ||| .|||.|    ||||.||... .|||.|.|.|.. .||||
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPDQGcwTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmTN-RKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKAC--------NPQYAGAIVVHCS
|||..   |||...| . ....| |||||.....     ..  ...||....|...|||.||| .|  .|.||..|...        .    | ..||||
ywpgev..tygdftvtllseehlddytvrtlllen....ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCs

AGVGRTGTFVVIDAMLDMMhterKVDVYGFVSRIRAQRCQ-MVQTDMQYVFIYQALLEH
||||||||..... ||...    .||..  | ..|.||.. .|||  ||.|.|.||||.
aGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 258-500 9.9e-70 229.4 In-house 1-239 (239) alignment 
Range on Protein: 258-500
Range on HMM: 1-239/239.0
EAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNK-FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD
||| |  || |||| ||. |||||| |  .   | |||||||..  |.   | .||.||  | .  |||||.|..  . |||.| | | .. || |||||
eaakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpd

QGCwTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTnrkpQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVID
     | |.||..    |. || .| | . |||.      .| . |.||| ||| |||     .| . .|.   .   |   |.||||||||||.|.|||
sts.kycnlrvtlrktevfadyiirtfvmsqvgqte....eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid

AMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
|||   . .. ||.. .|  || .| .||||  |||||. |.||
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_egg_pd Subfamily egg 258-511 5e-29 95.9 In-house 33-282 (307) alignment 
Range on Protein: 258-511
Range on HMM: 33-282/307.0
EAASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERkeCKCAQYWPDQ
. | ...|.|| |   .   | |||.|   .|    |.| |  ..|    |.|| || |  .||.|||||.....   |||.|  ||    .|  |||  
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka

G----CWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMtnrKPQRLITQFhFTSWPDFGVPFTPIGMLKFLKKVkaCNPqyagaIVVHCSAGVGRTGTFV
         |..|.   .|    |   |   .. ||     . .| .  .    .   .  ..|. .|. |...   .|     .||..  || ...|.|
esdslvtvpGslrienlkvdskadplfrvtklklvGgd...deerflehw.qgdvnnssdvysplrvlrklrnl..skp.....vvvqdilGvskaatlv

VID-AMLDMMHT-ERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALL---EHYLYGDTELEV
 |. |.|...     |  |   |  .| .|   |.. ..|.|.|. .|      .    ||.|
aieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsakeldv
subfamily_eak_pd Subfamily eak 258-414 1.5e-18 61.3 In-house 45-195 (332) alignment 
Range on Protein: 258-414
Range on HMM: 45-195/332.0
EAASKEENKEKNrYVNILPYDHSRVHLTPVEGVPDsDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ
. ... |. ..|  |.|.|||.  |.||.    ..  ||||| ..  .  .|.| .  ..|. |  ||.|. ||.. .||.. .  | |  |  .|.||.
setarleavnrn.vvkivpydrylvrltssqlnrl.GyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

G--CWTYGNIRVSVEDVTVLVDYTVRKFCIqQVGDMTNRkpqrlITQFHFTSWPDFGVP
.   . .| . |   .      . .|.. . ..|. | |     .  ...  | .. .|
treelkfGildverkefvkrniletrllel.skGnethr.....vlhykvfGwtettlp
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 259-500 3.1e-69 227.8 In-house 1-238 (239) alignment 
Range on Protein: 259-500
Range on HMM: 1-238/239.0
AASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNK-FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ
|| |  || |||| ||. |||||| |  .   | |||||||..  |.   | .||.||  | .  |||||.|..  . |||.| | | .. || ||||| 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

GCwTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTnrkpQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDA
    | |.||..    |. || .| | . |||.      .| . |.||| ||| |||     .| . .|.   .   |   |.||||||||||.|.||||
ts.kycnlrvtlrktevfadyiirtfvmsqvgqte....eryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida

MLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
||   . .. ||.. .|  || .| .||||  |||||. |.||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 259-503 1.6e-39 130.3 In-house 49-290 (305) alignment 
Range on Protein: 259-503
Range on HMM: 49-290/305.0
AASKEENKEKNRYVNILPYDHSRVHLTpveGVPDSDYINASFINGY-QEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD-
  | . .. |||| ..   |.| |.|      . |||| | ..      ...||.|||| ..|...|| |. ...   |||. .  |    |||||||  
nqsadiaitknryqdvpcqdqsavkld...kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaa

QGCWTYGNIRVSVEDVTVLVDYtVRKFCIQQ-VGDMTNRKPQRL-ITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNpqyaGAIVVHCSAGVGRTGTFVV
||     .  . ||.|.       |   ||  . ..|    |.. . ....| ||| |||   .  |..|  ..  .      ||||||||.||||| | 
qgeklelksgivvenvsgskpm.erdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgtiva

IDAMLDMMHTERKVD-VYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYL
|. .|. .  ....  .  .|  .| ||.  .|.|.||.||.. .|...|
ieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyfl
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 260-501 2.3e-90 297.2 In-house 4-241 (250) alignment 
Range on Protein: 260-501
Range on HMM: 4-241/250.0
ASKEENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECkCAQYWPDQGC
| | .||||||| .|...|.||| | ...|  .||||||||..||.|.. |||.||| ..|..|||||..|....||||.||||| ..  . |||| .. 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

WTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQ-YAGAIVVHCSAGVGRTGTFVVIDAM
 .||...||. .  .  |||.||. . .    .... .|.. |.||..||| ||| .   .|..||||.| ..|  .. ..|.|||||||.|.|..|||.
ekyGdvtvsllskeefadytkrklklsk....akkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidav

LDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
|. ...|..|||. .. ..|..| ..|..  ||||.|...|. 
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilka
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 261-430 1.4e-36 120.9 In-house 29-196 (297) alignment 
Range on Protein: 261-430
Range on HMM: 29-196/297.0
SKEENKEKNRYVNILPYDHSRVHLTpvEGVPDSDYINASFINGYQEKN--KFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQG
 ..    |||| .|| .| .||.|    .....||||| ..   .|..  |.| |||| ..||.|||....||.  .||||..|.|    ||| |||.  
krnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywpsvv

CWTYGNIRVSVEDVTVLVDYtVRKFCIQQVgDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKAC
        | || ..   |    .  . ..  .  |. .| ..   | |||| |||     . .|  .| .|
qerlkagdvvveflsstsde.fdrviltel.qliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcsc
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 262-500 3.1e-48 158.9 In-house 53-281 (290) alignment 
Range on Protein: 262-500
Range on HMM: 53-281/290.0
KEENKEKNRYVNILPYDHSRVHLTpvEGVpDSDYINASFINGYqeKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQG--C
|. . .|||| ..   | .|| |   .|  | ||. | ...|   |  || .||. ..|| |.|||. ....|.|||. .| |    ||.||.|..    
kntefkknrykdvvcndktrvilk..dGy.dGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

WTYGNIRVSVEDVTVLVDYTVRKfcIQQVGDMTNRKPQRLiTQFHFTSWPDFGVPFTPIGMLKFLKKVKACnpqyAGAIVVHCSAGVGRTGTFVVIDAML
 |.|.| |     .   . ...|  .  | |. . |  .|   ..  ||||  |. . . .|. |. ..      .| .|||||||.||||||| |.. |
ltfGeitvlcseeddkdaniikk..tlsvrdkdsGkehkl.khlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievgl

DMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
...   ...|. . |  .|  | . || |.||. . ..||.
qilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 263-501 9.2e-65 213.3 In-house 18-263 (270) alignment 
Range on Protein: 263-501
Range on HMM: 18-263/270.0
EENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINASFINGYQE-KNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDqgcWT
  .|. ||| .|||  ..|| | ..|  . . |||| ...|... |.|.|||.||.. |...|||||||... .|||.|.|.|.   ||..|||     .
argkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa...ep

YGNIRVSVEDVTVLVDYTV-RKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPI------GMLKFLKKVKACNPQYA--GAIVVHCSAGVGRTGTF
  .....  ...||.  .. ... |..   ....  .| .. |....||| ||| ..        .|| |..|.. . . .  . ..||||||||||||.
kekvkledgkikvlalseekeegyiltrlrleekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

VVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
...| .. ......||||   ....| .|...||.  || |.|.|..|.
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 263-500 3e-33 109.7 In-house 50-288 (310) alignment 
Range on Protein: 263-500
Range on HMM: 50-288/310.0
EENKEKNRYVNILPYDHSRVHLTpVEGVPDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGC-WT
...  |||| ...  | |||.|. ..     ||| | ...    .. || .||| . |. ||||||... . .|... .  |    ||  |||  |   |
kkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtet

YGNIRVSVEDVtVLVDYTVRKFCIQQVGDMT--NRKPQRL----ITQFHFTSWPDFGVPFTPIGMLKflKKVKACnpQYAGAIVVHCSAGVGRTGTFVVI
|| |||.        .. . ....  | |    . .|  |    ..  ..  ||| |||      .   ... |      |  |||||||..|... | .
ygcirvtnlse.sseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..qrllaq..vrhgpcvvhcsagkdrlyvvval

DAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
.  .| ..   |||.   .. .. .| . .||..||..| .  . 
klkidkldrglkvdaeevktellksraiciqtelqyliidrvrii
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 264-500 1e-68 226.1 In-house 2-237 (237) alignment 
Range on Protein: 264-500
Range on HMM: 2-237/237.0
ENKEKNRYVNILPYDHSRVHLTPVEGVpdSDYINASFINGYQEK-NKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQG-CWT
||| |||| ||  |||||| |    .   ||||||....|..   .|.|||||| | . .|||.|.|... . |||.| | |..| || .|||.     .
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGNIRVSVEDVTVLVDYTVRKFCIQQVGDmtnRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQ--YAGAIVVHCSAGVGRTGTFVVIDAML
|| . ||.     . ||||| . ... .     |  ||| |..|||||| |||     .|.| |..   .|    .|  ..|||||||||| |.||||||
ygvltvslkkkeefsdytvrslllskrlt...lkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

DMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
   . .. ||.| .|  |  .|  ..||  |||||.|..||
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 264-503 3.1e-36 119.9 In-house 42-272 (288) alignment 
Range on Protein: 264-503
Range on HMM: 42-272/288.0
ENKEKNRYVNILPYDHSRVHLTpvegvPDSD-YINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTY
.|  ..|| |.   | .||.|.      |.| ||.|  .   . |...| || | . |.. .|.|. |..   |||...| |.   | |.|.| .   . 
anptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

gNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNpqyaGAIVVHCSAGVGRTGTFVVIDAMLDMM
  |.    .| .  .   .   .  .    . . . .. . |.  |.| |||   .  |..|. .|...      ||||.|||||||||...|  .|...
.rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevlkslq....kPivvhssaGvGrtgtlililialesl

HTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYL
  .  . .  .... |..| . .|| |||..... .||. |
rlddflgirsllaklreerfkaiqtemqylyvhrcvleell
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 264-369 5.5e-14 46.2 In-house 47-165 (349) alignment 
Range on Protein: 264-369
Range on HMM: 47-165/349.0
ENKEKNRYVNILPYDHSRVHLTP----V----------EGVPDSDYINASFING--YQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKE
|   |||| .||||.|||| |                 ..    ||||| ...   .. ..|.|| | |   ||.||...|  ..   .. ... ||   
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

CKCAQYWPDQgcwTYGNIRVSV
 || .|| .    .| ||.| .
ekcdiywqel...sysnitvkl
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 264-420 9.3e-10 31.7 In-house 26-161 (169) alignment 
Range on Protein: 264-420
Range on HMM: 26-161/169.0
ENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINAsfingyqeknkfiaaqgpkeetvndfwRMIWEQNTATIVMVTNLKERK----ECKCAQYWPD--Q
 |. |||    |   | ||.|  |     ||||||                           ||||| |.. ||.. .  ..     | .  |  |    
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtddknnfwpekedyqlhpavil

GCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGM
| |    . |  . |.....     | .  |    ...    .. .|...||. ||| .|. .
gewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspvhv
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 264-422 6.2e-09 28.9 In-house 25-162 (169) alignment 
Range on Protein: 264-422
Range on HMM: 25-162/169.0
ENKEKNRYVNILPYDHSRVHLTPVEGVPDSDYINAsfingyqeknkfiaaqgpkeetvndfwRMIWEQNTATIVMVTNLKERK----ECKCAQYWPD--Q
 |. |||    |   | ||.|  |     ||||||                           ||||| |.. ||.. .  ..     | .  |  |    
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtddknnfwpekedyqlhpavil

GCWTYGNIRVSVEDVTVLVDYTVRKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLK
| |    . |  . |.  .      | .. | .  ...  . .. .|...||. ||| .|. . .
Gewytdslyvrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhvgh
Y_phosphatase Protein-tyrosine phosphatase 265-500 1.1e-85 282.2 Pfam-A 1-235 (235) alignment 
Range on Protein: 265-500
Range on HMM: 1-235/235.0
NKEKNRYVNILPYDHSRVHLtpvEGVPD-SDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWP--DQGCWT
||.|||| .|||||..||.|   .| .. ||||||....||.||.||||.||| ..|..|||||.|.... .|||.|.|.|... |||||||  ...  |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGNIRVSVE-DVT-VLVDYTVRKFCIQQVGDMTnrkPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAML
||.|.| .. ...    .||.||. ... .. .    .| ..|.|.|.||| ||| .| ..|....||.  . .  | .|||||||||||||||..|..|
ygdikvelkekekedekeytlrklelkkkkees...ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

DMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
.....|..|||. .|...|.||..|||.  ||.|.|.|.||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 265-500 1.1e-85 282.2 In-house 1-235 (235) alignment 
Range on Protein: 265-500
Range on HMM: 1-235/235.0
NKEKNRYVNILPYDHSRVHLtpvEGVPD-SDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWP--DQGCWT
||.|||| .|||||..||.|   .| .. ||||||....||.||.||||.||| ..|..|||||.|.... .|||.|.|.|... |||||||  ...  |
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGNIRVSVE-DVT-VLVDYTVRKFCIQQVGDMTnrkPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAML
||.|.| .. ...    .||.||. ... .. .    .| ..|.|.|.||| ||| .| ..|....||.  . .  | .|||||||||||||||..|..|
ygdikvelkekekedekeytlrklelkkkkees...ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

DMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
.....|..|||. .|...|.||..|||.  ||.|.|.|.||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0041856 (Phosphotyrosine protein) phosphatases II 265-508 1.7e-56 186.0 In-house 1-177 (182) alignment 
Range on Protein: 265-508
Range on HMM: 1-177/182.0
NKEKNRYVNILPYDHSRvhltpvegvpDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTnlkerkeckCAQYWPdqgcwtygn
|..||||..||||||||          |.|||||... |..  ..|||.|||  .||.||.||..|..  |||..|         . .|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

irvsvedvtvlvdytvrkfciqqvgdmtnRKPQRLITQFHFTSWPDFGVPFtPIGMLKFLKKVKAcnpqYAGAIVVHCSAGVGRTGTFVVIDAMLDMmht
                              . .||..|.....|||.|||  .  .|.|...|..      |...||||||||||||.|... |. .   
.............................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl...

erKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTE
  .|...  |. .| .|..||.|  ||.|...||||..|...|.
..gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 265-493 1e-31 104.8 In-house 50-272 (301) alignment 
Range on Protein: 265-493
Range on HMM: 50-272/301.0
NKEKNRYVNIlPYDHSrvhlTPVEGVPDSD--YINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGC--W
.|.|.|| .. | . |    | || . |     | | .|.   . ..|||.||| ..| .||| |.   .  .|||...  |..| ||..| | .     
pkdkhryptv.PckPs....tavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekl

TYGNIRVSVEDVTVLVDYTVRKFCIqQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNpqyaGAIVVHCSAGVGRTGTFVVIDAMLD
  |  .. ...  ....  . |  . .| | |.. . | .| . ...|.| ||| . . . .... ||  .      ||||||||.||. .|.  . .  
digrfkikiknkelilnkkiskrtl.evedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylar

MMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVF
 .........   . ..| .| . |||  |  .
eveadptieltealkhlrehrwngvqtnsqlyw
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 265-358 1.6e-24 81.3 In-house 47-154 (350) alignment 
Range on Protein: 265-358
Range on HMM: 47-154/350.0
NKEKNRYVNILPYDHSRVHLT----PVEG----VPDSDYINASFINGY----QEKNK--FIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKC
   ||||.|||||.||||.|     . ..    .  .|||||....      . . .  .||.|.|  .||.||...| . .   |...|.. |    ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

AQYWPDQG
 .||.. .
yrYWqegs
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 265-356 8e-14 45.8 In-house 34-124 (332) alignment 
Range on Protein: 265-356
Range on HMM: 34-124/332.0
NKEKNRYVNILPYDHSRVHLTPVEGvpDSDYINASFINGYQEKNKFIAAQGPKEE-TVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD
| . ||   .  .||||| |.| .|    |. |||...|| .|. .| || | .. |   ||||. |.. . |... .. |... |.     |
nmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisd
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 269-503 5.9e-22 73.1 In-house 23-257 (290) alignment 
Range on Protein: 269-503
Range on HMM: 23-257/290.0
NRYVNILpYDHSRVHLTPVEGVPDSDYINASFINgYQEKNKFIAAQGPKEET-------VNDFWRMIWEQNTATIVMVTNLKERKEC----KCAQYWPDQ
.|. . |   ..|| |        .||| |...  . .  ..|. | |.|..       ...|| |. . .   .||. . .|...      ||.| |..
qRlevpL.veatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpes

G--CWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgdmtNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKaCnpqYAGAIVVHCSAGVGRTGTFVVI
     ..... |.  .     |  .|. ...      . . .  .|   . .| .  |. ... .|. ..||| .   .  ...|||  |. |  ..  |
vgeelkfkgltvkCkskekeddvetRelvvkf.....ddeeeftvtHsllkgWnklnvqedtktllsliqkvk.a...sktpvivHcvdGiSrsAalaai

DAMLDMMH-TERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLehyL
.    ..  |. .| .   .. .| || ......... |.  ...   |
ilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv...l
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 275-412 2e-10 35.1 In-house 3-125 (130) alignment 
Range on Protein: 275-412
Range on HMM: 3-125/130.0
LPYDHSRVHltpvegvpDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKEckcaqYWPDQGCWTYGNIRVSVEDVTV
|... ||..        . .||||||.   .  .... .| |  .|  |||.|. |.    .|..  ..|  |     ||||     . . .. |     
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeede.....ywpdsePlewyeediivtltdr

LVDYTVRKFCIQQVGDMTNrKPQrLITQFHFTSWPDFG
     ..   ..   |. .   |  .| |. . ||  |
defknikasnleiesdlne.shq.altmfqisnwpsdg
0044763 (Phosphotyrosine protein) phosphatases II 276-506 1.9e-42 140.3 In-house 1-175 (178) alignment 
Range on Protein: 276-506
Range on HMM: 1-175/178.0
PYDHSRVHLTPVEGVPDSDYINASFINGYqeknKFIAAQGPkeetvNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCwtygnirvsvedvtvl
|.|..||.|...||.. |||||||.| ..     ......|      |......|..  .||..|. .|.  .|| .|||..                  
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

vdytvrkfciqqvgdmtnrkpqrliTQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMmhterKVDVYGFVS
                          |.... .||.|||  .  .|.|.. .... ..  |...|||||||||.||.|... |. .     .....  ..
.........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaie

RIRAQRCqMVQTDMQYVFIYQALLEHYLYGD
..|..|. .|... |. ..|.  |... ..|
lvrerRp.ivpnpgqlrqLyefelrllkesd
0046846 (Phosphotyrosine protein) phosphatases II 285-500 6.6e-46 151.6 In-house 4-171 (176) alignment 
Range on Protein: 285-500
Range on HMM: 4-171/176.0
TPVEGVPDSDYINASFINGYqeknKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDqgCWTYGNirvsvedvtvlvdytvrkfc
..    .|.|||||..| |.    ..|| ||| ..|. ||..|..|..  ..|..|...| . .||..|||.  ....|                     
rllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi....................

iqqvgdmtnrkpqrlitQFHFTSWPDFGVPFTpIGMLKFLKKVKACNPQYaGAIVVHCSAGVGRTGTFVVIDamldMMHTERKVDVYGFVSRIRAQRC-Q
                 |.... |||.|||     .|..|. .. .  .  | ..||||||.|||||.|...    ....|. ..|.  ....|.||. .
.................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplg

MVQTDMQYVFIYQALLE
.|||. || |.|...|.
avqtpeQyrflyefell
0051429 (Phosphotyrosine protein) phosphatases II 291-524 6.1e-57 188.6 In-house 2-246 (272) alignment 
Range on Protein: 291-524
Range on HMM: 2-246/272.0
PDSDYINASFINGYQE---KNKFIAAQGPKEETVNDFWRMiWEQNTATIVMVTNLKERKECKCAQYWP------------DQGCWTYGNIRVSVEDVTVL
| |.||||....||     ........|| . |..||||. .|..  |||..... ||. .|| .|||            .    .||..|| .  ...|
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

VDYTVRKFCIQQVGDMTNRkpqRLITQFHFTSWPDFGVPFTPigMLKFLKKVKAcnpqyAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVD------
 ||..|....  . ....    | ....|.|.|||.|||  .  .|..|. . .      |...||||||..||||.|... .|  .. |  ||      
ldyilrellltlllsagea...revmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltn

--VYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHyLYGDTELEVTSLETHLQKIYNK
  ....|...|||| ..|||..||.|.|.||||  |.. .. ..  |...|. | ..
lyleeaveelraqrpgavqteeqylflyeallel.lrsllsvraeyllaaldaidee
0043147 (Phosphotyrosine protein) phosphatases II 291-496 8.7e-47 154.3 In-house 3-155 (172) alignment 
Range on Protein: 291-496
Range on HMM: 3-155/172.0
PDSDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLkerkeckcaqywpdqgcwtygnirvsvedvtvlvdytvrkfciqqvgD
..|||||||....|   ..||| |||  .|..|||||..|..  .||..|.|                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...............................................l

MTNRKPQRLITQFHFTSWPDFGVPfTPIGMLKFLKKVKA-CNPQYAGAIVVHCSAGVGRTGTFVVIDAMLdmmhteRKVDVYGFVSRIRAQRCQMVQTDM
 .  . .||. |.....|||.||| ..  .|.||. ..  .. .  |...||||||||||||.|... ||      ......  |. .|..|...||.. 
ydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYVFIYQ
|| |.|.
qyrflyy
0051082 (Phosphotyrosine protein) phosphatases II 291-499 2.8e-38 126.2 In-house 1-150 (151) alignment 
Range on Protein: 291-499
Range on HMM: 1-150/151.0
PDSDYINASFINGYqeknkFIAAQGPkeetVNDFWRMIWEQNTATIVMVTNLKERKecKCAQYWPDQGcwtygnirvsvedvtvlvdytvrkfciqqvgd
| |||||.|.. |.     ... .||     .||.....|..  |||......||.  .|..|.|..|                                
plsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg................................

mtnrkpqRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKAcnpQYAGAIVVHCSAGVGRTGTFVVIDAMLdMMhterkVDVYGFVSRIRAQRCQMVQTDMQ
       . ........|||.|.| ..  .|.||... .   .  | ..||||||.|||||.|... || ..     |...  .. .|..|. .||. .|
.......ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylml.lg.....vsleealeeyrlkrpgvvqpnqq

YVFIYQALL
..|...|||
flfqlfall
0036282 (Phosphotyrosine protein) phosphatases II 293-496 9e-51 167.3 In-house 2-164 (174) alignment 
Range on Protein: 293-496
Range on HMM: 2-164/174.0
SDYINASFINGYQEKNKFIAAQGPKEetvndFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDqgcwtygnirvsvedvtvlvdytvrkfciqqvgdmT
|||||||.....   ...|| ||| .     ||.|..|..  |.||....||.. .|| .|||.                                   .
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................l

NRKPQRLITQFHFTSWPDFGVPFTPIgMLKFLKKVKACNPQ-YAGAIVVHCSAGVGRTGTFVVIDAMLDMMHtERKVDVYGFVSRIRAQRCQMVQTDMQY
   . ||. |.... |||.||| ..| .|.|.| |. .  .   | ..||||||||||||.|... || ... |. ||.. .| ..| ||..||||. ||
redlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQy

VFIYQ
 |.|.
rflyy
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 293-412 5.8e-10 33.2 In-house 122-234 (244) alignment 
Range on Protein: 293-412
Range on HMM: 122-234/244.0
SDYINASFINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKEckcaqYWPDQGC--WTYGNIRVSVEDVTVLVDYTVRKFCIQqvGD
  ||||||.       ..| .| |  .|  |||.|. |.    .|..  ..|  |     ||||     |   .| |.. |   . .    .. |.   |
ntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeede.....ywpdseplewyeeditvtltdrdefknikasnleie..sd

MTNrKPQrLITQFHFTSWPDFG
| .   |  .| |  . ||  |
mne.shq.altmfqisnwpsdg
0049260 (Phosphotyrosine protein) phosphatases II 300-496 1.3e-43 143.6 In-house 1-144 (152) alignment 
Range on Protein: 300-496
Range on HMM: 1-144/152.0
FINGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWpdqgcwtygnirvsvedvtvlvdytvrkfciqqvgdmtnrkpqrl
||.||  ...|||.||| ..|..|||||..|..  ||||.|.| |....||.||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

itQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYAGAIVVHCSAGVGRTGTFVVIDAMLdmmhteRKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQ
  |.... |||.|||  .. .| .|. .. .. .  | ..||||||||||||.|... ||      ..|... .|...|..| ..|..  |. |.|.
..qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 302-366 1.3e-11 38.5 In-house 230-292 (440) alignment 
Range on Protein: 302-366
Range on HMM: 230-292/440.0
NGYQEKNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERkecKCAQYWPDQ-GCWTYGNIR
.||  || |||.| | . || ||||.. . . .||.|. .|...    |. ||| .    |.| . 
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpft
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 305-500 2.5e-07 23.6 In-house 112-307 (346) alignment 
Range on Protein: 305-500
Range on HMM: 112-307/346.0
QEKNKFIAAQGPK---EETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQGCWTYGNiRVSVEDVTVLVDYTVRKFCIQQVGDMtNrkPQRLIT
| ..|.| || |.   |  |.||| ||....   . ..      |.   . .  ..| . |   .. ...    |    ... |. . .  |   . .| 
qfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytg.kmfinnrradvsgdpkeytievlpeg.n..sdsvic

QF-HFTSWPDFGVPFTPIGMLKFLKKVKACNP-QYAGAIVVhCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALL
|  | . |  .  |   . ..|.... .. .  | ||  ||    | ||. .|.     .. .    . ...  .  |. ||   |..  ||  ||  ..
qvhhhapwkhlqqppktlpiikmihqflsekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivf

E
.
d
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 306-494 1.9e-28 93.8 In-house 88-280 (302) alignment 
Range on Protein: 306-494
Range on HMM: 88-280/302.0
EKNKFI-AAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPDQ--GCWTYGNIRVSVEDVT-VLVDYTVRK-F---CIQQVGDMTNRKPQ
.|.|       || .|.. .| .| . |.| .| .....| .| |||.|. |.  |  ..|.  |   .|   | ..| .| |    ..   . ...| .
kkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvk

RLITQFHFTSWPDFGVPFTPIGMLKFLkkvKACNpQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFI
. .  ..|..||| | |  .   |. |   | |.  |  ...||||||||||||.| |   ...  ...  |.   |  .|. |   ||.. | ...
ktvdilafsawpdhGapkeaytaldil...kfce.sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyl
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 307-496 4.6e-29 96.0 In-house 4-198 (199) alignment 
Range on Protein: 307-496
Range on HMM: 4-198/199.0
KNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD--QGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgDMTNRKPQRLITQFH
. ..||.| |  ||. |||.|.||  .  |||| . .  ||.  . |||    |.  ||.. |... .|.  |||.  . . .  . |     | |... 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltn..nttappstreishyq

FTSWPDFGVPFTP--IGMLKFLKKVKACNPQY-AGAIVVHCSAGVGRTGTFVVIDAMLDmMHTERK---VDVYGFVSRIRAQRCQMVQTDMQYVFIYQ
|||| .   |     .|..   ..|     |     ..|||| | | || || .|  .   | | |   ||..    |.|  || .. .  .| ||||
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvr.sheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 307-496 4.8e-29 95.9 In-house 3-197 (198) alignment 
Range on Protein: 307-496
Range on HMM: 3-197/198.0
KNKFIAAQGPKEETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD--QGCWTYGNIRVSVEDVTVLVDYTVRKFCIQQvgDMTNRKPQRLITQFH
. ..||.| |  ||. |||.|.||  .  |||| . .  ||.  . |||    |.  ||.. |... .|.  |||.  . . .  . |     | |... 
qrryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltn..nttappstreishyq

FTSWPDFGVPFTP--IGMLKFLKKVKACNPQY-AGAIVVHCSAGVGRTGTFVVIDAMLDmMHTERK---VDVYGFVSRIRAQRCQMVQTDMQYVFIYQ
|||| .   |     .|..   ..|     |     ..|||| | | || || .|  .   | | |   ||..    |.|  || .. .  .| ||||
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvr.sheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 312-511 1.2e-19 65.4 In-house 39-229 (255) alignment 
Range on Protein: 312-511
Range on HMM: 39-229/255.0
AaqgpkeeTVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD--QGCWTYGNIRVSVEDvtVLVDYTVRKFCIqqVGDMTNRKPQRLITQFHFTSWP
        ||. |...|  ..| ..||.....| .  || .|.|   ..   . .. |.. .     |  .|   |  .  ....|  . .. .... |.
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtlei..tstlgekkkthtvkhysykGWi

DFGVPFTPIGMLKFLKKVKACNPqyagaIVVHCSAGVGRTGTFVVIDAMLD----MMHTER--KVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYl
.   |  .  .|. || |.   .     .|||||.|.||. .||... .       ..|    ..|   ..  .| .| . ..| .|  |    .|. . 
eknaPelareilnilkvvrdsks.....vvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldlv.

YGDTELEV
.  .||| 
fpkgelea
subfamily_hpo-7_pd Subfamily hpo-7 319-512 6.9e-17 56.2 In-house 45-237 (263) alignment 
Range on Protein: 319-512
Range on HMM: 45-237/263.0
ETVNDFWRMIWEQNTATIVMVTNLKERKECKCAQYWPD--QGCWTYGNIRVSVEDVTVlvDYTVRKfcIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFT
.|.. |...|  ..| ..||... .|    || .|.|    .   . |. |.. .|    |  ..   .. .  . ..|  . .... .. |..   |  
qtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllkt..lellstlgeKkkthtvkhysykgWiekndpel

PIGMLKFLKKVKACNpqyagAIVVHCSAGVGRTGTFVVIDAMLD----MMHTER--KVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYGDTELE
.. .|. || ..         .|||||.|.||.  |.|.. .       ..|    ..|   ..  .| .| . ..| ||  |    .|.  |   .. |
areilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdfvlnnfakge

VT
. 
le
0048076 (Phosphotyrosine protein) phosphatases II 353-500 5.9e-27 89.5 In-house 2-141 (145) alignment 
Range on Protein: 353-500
Range on HMM: 2-141/145.0
YWPDQ--GCWTYGNIRvSVEDVTVLVDYTVRK-FCIqqvgDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYaGAIVVHCSAGVGRT
|||..  . . .|..  ...|.  | |. ..  ...     .. . . ||..|.....|||.|||  .  .|.||. .... ..  | ..||||||||||
ywpseilpglylgslp.taldlellkdlgittvlnl....tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRt

GTFVVIDAMLDmmhteRKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
||.|... ||      ..|...  . ..|.|| ..|... |. |.|...||
gtlvaaylmll.....lgvsleealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 362-496 6.8e-26 86.1 In-house 13-139 (144) alignment 
Range on Protein: 362-496
Range on HMM: 13-139/144.0
YGNIRvSVEDVTVLVDYTVrKFCIQQVGDMTNRKPQRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYaGAIVVHCSAGVGRTGTFVVIDAMLdm
.|..  ...|.  | .. . .  |  . .  .  . | ..|.....|||.|||  .  .|.||. .... ..  | ..||||||||||||.|... |.  
lgslp.taldlellkklgi.ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk..

mhtERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQ
   .......  . ..|..|...|... |. |...
...klglsleealalvrsrrpgavpnpgqlrfLle
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 391-501 7.4e-14 45.8 In-house 212-343 (349) alignment 
Range on Protein: 391-501
Range on HMM: 212-343/349.0
MTNRKPQRLiTQFHFTSWPDFGVPFTPIGMLKFLKkVKA-----------CNPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTE----RKVDVY----
....||  |  |. .  |.| .. . || .|. |. ||             . .   ...|||||| ||||..| .| .|....       |...     
lavekPyel.lqlqvknwldlslllnPisilqale.vkndliddlfarlyldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallk

----GFVSRIRAQRCQMVQTDMQYVFIYQALLEH
      |  .| || .|||   |...||.|||..
DlisiivnelrkqrismvqnlaqfiaiyealLky
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 397-539 1.6e-25 84.3 In-house 88-231 (440) alignment 
Range on Protein: 397-539
Range on HMM: 88-231/440.0
QRLITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQ-YAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIY
 | . |.|. .||| |||     .||... |. .. .   | ..||||||.||||  ...|..|   .   ..|.. |.. .| .| |||||  ||.|..
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

QALLEHYLYGDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKK
.|.||  | ||| .    .  ....|    | | .. |..||. 
eavlegllcgdtliledditerveqiqwpnphtdksplqqefeg
PTPc_DSPc_SM00012 400-500 5.3e-36 118.4 In-house 2-105 (105) alignment 
Range on Protein: 400-500
Range on HMM: 2-105/105.0
ITQFHFTSWPDFGVPFTPIGMLKFLKKVKACNPQYA--GAIVVHCSAGVGRTGTFVVIDAMLDMMHTE-RKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQ
....|.|.|||.||| ..  .|..|..|| .. . .  . .|||||||||||||||..| .|.....| ..||.. .|...| || .||||..||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 400-501 3.9e-18 60.3 In-house 217-343 (350) alignment 
Range on Protein: 400-501
Range on HMM: 217-343/350.0
ITQFHFTSWPDFGVPFTPIGMLKFLK-KVK----AC-----NPQYAGAIVVHCSAGVGRTGTFVVIDAMLD---M----MHTERKVDVY--------GFV
. |...  |.| .. . |. .|. |. | .     .     . . . .|.||||||||||||.| .| .|    .     .  ||.||           |
vyqlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiiv

SRIRAQRCQMVQTDMQYVFIYQALLEH
 ..| || .|||.  |..|||.||| .
nelrkqrismvqnldqfifiYeallfy
subfamily_PTPDC1_pd Subfamily PTPDC1 402-494 4.2e-09 31.1 In-house 84-168 (182) alignment 
Range on Protein: 402-494
Range on HMM: 84-168/182.0
QFHFTSWPDFGVPfTPIGMLKFLKKVKACnPQyAGAIVVHCSAGVGRTGtfVVIDAMLdmMHTeRKVDVYGFVSRIRAQRCQMVQTDMQYVFI
 ..  .|.|.||. .   .|   | |. .  |  |.. ||| || ||||  |.| ..|  ... ....    .. .|..| . .||  |  ..
yvynfgwkDygva.sleriLdivkvvafa.lq.egkvavhChaGlGrtG..vliacyl..vya.krltaekaiklvrskrpksiqtreqvelv
0038934 (Phosphotyrosine protein) phosphatases II 403-455 1.8e-08 29.8 In-house 82-135 (194) alignment 
Range on Protein: 403-455
Range on HMM: 82-135/194.0
FHFTSWPDFGVPFTPIGMLKFLKKVKACNPQY-AGAIVVHCSAGVGRTGTFVVI
..   .||.|.. .   .|.||. |.  . .   |...||| ||.|||||.|. 
ylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
subfamily_DSP23_pd Subfamily DSP23 404-496 3.5e-06 21.7 In-house 55-140 (148) alignment 
Range on Protein: 404-496
Range on HMM: 55-140/148.0
HFTSWPDFgVPFTPIGMLKFLKKVKACNPQyAGAIVVHCSAGVGRTGTFVVIdamldMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQ
.    .|.  | ..  . .|.. |.  . . . |. |||  | |||||..        .  |||.     .. .| .|   |.|  |   ...
vrlriddy.hppaleqvvefvrvveeaeek.neavsvhcllgrgrtgtmlac.....ylvkerklaaaeaiaevrrlrpgsvetveqeklvrd
PTEN_1 407-454 8e-07 24.1 In-house 101-149 (196) alignment 
Range on Protein: 407-454
Range on HMM: 101-149/196.0
SWPDFGVPfTPIGMLKFLKKVKACNPQ--YAGAIVVHCSAGVGRTGTFVV
...|.|.| .   .....|... .  .    ....||| ||.||.|| | 
pieDhgap.slselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvva
subfamily_CDC14_pd Subfamily CDC14 420-464 7.7e-07 23.3 In-house 252-292 (328) alignment 
Range on Protein: 420-464
Range on HMM: 252-292/328.0
MLKFLKKVKACnpqyAGAIVVHCSAGVGRTGTFVVIDAMLDMMHT
. |||. .. .     |||.||| ||.|||||..    | .   |
vkkfleiaeka....eGaiavhCkaGLGrtGtLiacylmkhyrft
subfamily_eak_pd Subfamily eak 421-505 3.5e-10 33.8 In-house 224-308 (332) alignment 
Range on Protein: 421-505
Range on HMM: 224-308/332.0
LKFLKKVKACNPQYAGaiVVHCSAGVGRTGTFVVIDAMLDMMHTERK--VDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEHYLYG
  .||| .   | .|   .. .. |  |.|.||||| .. ..   .|    |  .. ... .|   | ...|. |||...|.. |  
sstlkkyihtppsfap..iiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrr
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 424-500 9e-16 52.6 In-house 218-293 (297) alignment 
Range on Protein: 424-500
Range on HMM: 218-293/297.0
LKKVKACNPQYAgAIVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
|. ..|  |. |  ..|||||||||.|  |  |..|...  .|  ||  ..| .| || ..|||  |. ..|.| |.
leslraemprna.yllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
PTPc_motif_SM00404 427-487 3.2e-06 22.1 In-house 73-126 (140) alignment 
Range on Protein: 427-487
Range on HMM: 73-126/140.0
VKACnPQYAGAIVVHCSAGVGRTGTFVVIDAMLDMMHTerKVDVYGFVsriRAQRcQMVQT
....  .  |...||| ||| |..|...   |  .  .    ..| ||   . .| .... 
iena.ekkggkvlVHCqaGvSRSatliiaYlmryrqls..laeayefv...kerR.piisp
subfamily_CG42327_pd Subfamily CG42327 435-500 9e-16 52.4 In-house 247-313 (319) alignment 
Range on Protein: 435-500
Range on HMM: 247-313/319.0
AGAIVVHCSAGVGRTGTFVVIDAMLDMMHTE-RKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLE
 | .||||| ||||||. .  |  .  . .  | ||.   || .| .|.. |.|  || |||. | |
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlse
subfamily_PTEN_pd Subfamily PTEN 437-501 3.3e-06 22.2 In-house 116-181 (184) alignment 
Range on Protein: 437-501
Range on HMM: 116-181/184.0
AIVVHCSAGVGRTGTFVVIdAMLDMMHTERKVDVYGFVSRIRAQRCQMVQ--TDMQYVFIYQALLEH
 .|||| || ||||. .|   .| ....|.. ..  . ...|..  . |.    . ||  |..|||.
vvvvHCkaGkGRtGvliva.yllkslllekaeealelfaeaRtknkkgvtiPsqrRYveYyekllee
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 438-501 7.6e-15 49.1 In-house 1-64 (69) alignment 
Range on Protein: 438-501
Range on HMM: 1-64/69.0
IVVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
.|||||.| ||||||. |   .  . .|. ||..  |  .|  |  ||  ...|.||. || | 
mvvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 439-501 9.1e-14 45.6 In-house 1-63 (69) alignment 
Range on Protein: 439-501
Range on HMM: 1-63/69.0
VVHCSAGVGRTGTFVVIDAMLDMMHTERKVDVYGFVSRIRAQRCQMVQTDMQYVFIYQALLEH
|||||.| ||||||. |   .  . .|. ||..  |  .|  |  ||  . .|.||..|| | 
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 505-799 9.3e-107 351.7 In-house 1-297 (298) alignment 
Range on Protein: 505-799
Range on HMM: 1-297/298.0
GDTELEVTSLETHLQKIYNKIPGTSNNGLEEEFKKLTSIK--IQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDS
|.||.|...|...|||. .. . ..  |...||..|.|..  |...... .. |.| ||||  .||.... ||..  . ..|..||.||||...|.....
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

YIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGI
.||.|.|| .|.||||||..| .. .|||||.||| .. |. .|||..|   ||.|||.|...||   ..|| | |....|.|.|..||.||  ||. |.
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgv

PSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA
|.  . .. ... |...|||.||.|..|.|||| ||.|||.|...||||||.|  .||||.|| || .||..||| ||| |.|..|.|..|.|.|..
penatsvldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
0051299 (Phosphotyrosine protein) phosphatases II 506-792 5.5e-105 346.2 In-house 2-286 (288) alignment 
Range on Protein: 506-792
Range on HMM: 2-286/288.0
DTELEVTSLETHLQKIYnkipGTSNNGLEEEFKKLTSIKIQnDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIA
|||..|..|. ...|..     ....||.|||..|.|....  ......||.|..|||   |.||. .||.. |  |.|..||.|||.||||..|  .||
dteisveellklvlkll....angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIa

SQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNT----RENKSRQIRQFHFHGWPEVG
 |||| .|.||||||.||...  |||||.|.|.|.||||||||..| . ||||||.|..||....|||| | |||.     ...||....||...||. |
tqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhg

IPSDGKGMISIIAAVQKQQQqSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
.|.. . ..... .|.|... ||..|. |||||| ||||||.|| ..||....|| .||...|| || |||.||||.|||.|.|... ||.
vpdspellldflrlvrkala.sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRG_pd Subfamily PTPRG 514-794 8.7e-87 286.6 In-house 6-289 (563) alignment 
Range on Protein: 514-794
Range on HMM: 6-289/563.0
LETHLQKIYNkipgTSNNGLEEEFKKLTSIKIQN-DKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENT-DYVNASFIDGYRQKDSYIASQGPLL
.. |. ...      .. |..|||..|.|  |..  .. . . | | .||| |.|..|.  || .    |.... ||.||..||||.... .||.|||| 
fakhvaslha....dgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplk

HTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRE------NKSRQIRQFHFHGWPEVGIPSD
.|..|||||||| ..  |||.|.|.|||..|| .|||.|. . || ..| |..||   .|||| | . |..       .. ...||.|.  ||..| |. 
dtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPeh

GKGMISIIAAVQKqQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA
    .. .   ..  ...   ||.||||||.|||||...|.|.|.....| . .||...| .|.||...||| ||| | .....| | .
slpvLifvkkssa.ankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
0039614 (Phosphotyrosine protein) phosphatases II 516-795 4.8e-96 316.9 In-house 17-292 (297) alignment 
Range on Protein: 516-795
Range on HMM: 17-292/297.0
THLQKIYNKIPGTSNNGLEEEFKKLTSIKIqnDkMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGE-ENTDYVNASFIDGYRQ-KDSYIASQGPLLHT
..|  .. ... .|...|..||..| |.|.  | .....||.|..|||   |.||...||.. ...|  ...||.|||..|||.. .. .||.|||| .|
svldlllllekansktllllefeellslkp..d.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpet

IEDFWRMIWEWKSCSIVMLTELEERGQeKCAQYWPSDGLvSYGDITVELKKEEECESYTVRDLLVTNtrENKSRQIRQFHFHGWPEVGIPSDGKGMISII
.||||||.||... .|||||.|.|.|. |||||||..|   |||.||.|.|.|... |||| | |||  ...||....|...|||. |.|.. . .....
vedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslelllefl

AAVQKQQQQS-GNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF
 .|....... ...|. |||||| ||||||.|. ..||... || .||...|| || |||..|||..||.|.|....|..  .
elvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPN6_pd Subfamily PTPN6 516-794 3.8e-78 257.6 In-house 11-299 (306) alignment 
Range on Protein: 516-794
Range on HMM: 11-299/306.0
THLQKIYNKIPGTSNNGLEEEFKKLTSIKIQNDKM-RTGNLPANMKKNRVLQIIPYEFNRVIIPvKRGEENTDYVNASFIDGY--RQKDSYIASQGPLLH
 . ... ..   ....|.||||..|   . ..    . |. | |..|||   |.|.. .|||.  . .  ..||.||..|..    .. ||||.|| | .
qrvselekeeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclet

TIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGL-VSYGDITVELKKEEECESYTVRDLLVT-NTRENKSRQIRQFHFHGWPEVGIPSDGKGMI
|..|||||.|. .|  |||.|.  |||.||||.|||.     .||.|.|.  .|.. ..|..|.|.|. .......|...|.||. ||. |.|.| . ..
tvsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavL

SIIAAVQKQQQQSG---NHPITVHCSAGAGRTGTFCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA
. .  |...|...    . || |||||| ||||||  . ..|. .. .|.   .|. ..|||.| ||  .||| .|| | ||....||..
dfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
0043336 (Phosphotyrosine protein) phosphatases II 517-792 1.7e-98 324.7 In-house 6-277 (278) alignment 
Range on Protein: 517-792
Range on HMM: 6-277/278.0
HLQKIYNKIPGTSNNGLEEEFKKLTSIKIqnDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIED
.|.| ....  ... .|..||..|.|.|.  | .....||.|..|||   |.||...||.. .  |....||.|||..|||.... .||.|||| .|.||
dllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetved

FWRMIWEWKSCSIVMLTELEERGQEKCAQYWPsDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV
||||.||... .|||||||.|.|..||||||| .| . |||.||.|.|||... ||||.| |||.....||.....|..|||. |.|.. . ..... ||
FwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkav

QKQQQqSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
..... . |.|. |||||| ||||||.|| ..||... || .|....|| || |||..|||..||.|.|....||.
reale.dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 517-792 4.6e-95 314.1 In-house 13-304 (307) alignment 
Range on Protein: 517-792
Range on HMM: 13-304/307.0
HLQKIYNKIPGTSNNGLEEEFKKLTSIKIQ-NDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGE-ENTDYVNASFI--------DGYRQKDSYIAS
.| ..... . ....||..||.|| |.... ........||.|..|||   |.||. .||.. .  |. |..||.|||..        |||..|. .|| 
kllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLV-SYGDITVELKKEEECESYTVRDLLVTNT-RENKSRQIRQFHFHGWPEVGIPS
|||| .|.||||||.||...  |||||||.|.|.||||||||..| .  ||..||.|..||....|||| | ||..  ...||....||..|||. |.|.
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp

DGKGMISIIAAVQKQQQQS-GNHPITVHCSAGAGRTGTFCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
. . ....| .|.| .... ...|. |||||| ||||||.|. ..|.....||.   .|....|| || |||..||..|||.|.|....|..
sfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_PTPRB_pd Subfamily PTPRB 517-793 6.3e-89 292.9 In-house 11-286 (293) alignment 
Range on Protein: 517-793
Range on HMM: 11-286/293.0
HLQKIYNKIPGTSNNGLEEEFKKLTSIKIQnDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIED
.... ..|.   |. .. ||...| ... .  .. . .|..| .|||  .|.||. .|| .   ..|...||.||..|.||...  .||.|||| .|..|
kfeehvkkmkadsdlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvdd

FWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD-GLVSYGDITVELKKEEECESYTVRDLLVTNtrENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAA
||||.|| ||  |||||.| |.|..|| .|||.|   | ||||.|.|..||| | ...|.|....  |...|..||.||  ||. |.|.. | ..... .
fWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrt

VQKQQ-QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
|.... ... ..||.|||||| |||||| || ..|.... | ..|.| .| .|| .| ..||| .|| | ...|.... 
vreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
subfamily_PTPN9_pd Subfamily PTPN9 518-792 5.4e-84 276.7 In-house 3-290 (297) alignment 
Range on Protein: 518-792
Range on HMM: 3-290/297.0
LQKIYNKIPGTSNNGLEEEFKKLTSIKIQnDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDF
.... . .  . ..|| .|.... . ...  .. . .|.||..|||   .. |.  || .. . ..|..||.||.|.|||.||...|| |||| .|..||
ieelvayvkekgkrGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdf

WRMIWEWKSCSIVMLTELEERGQEKCAQYWP--SDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAA
|||.|| .   ||| | ..|||. ||.||||  ..   ..||..|.  . || | |.|| | ..|.....||..  | | .||. |.||... .. .. .
WrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlek

VQKQQQQS------------GNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
|...| ..             . || |||||| ||||||..|   |.|.. .| .||..||| || || ...|| |||||||. | || 
vrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
0050432 (Phosphotyrosine protein) phosphatases II 520-799 6.2e-105 346.2 In-house 34-306 (308) alignment 
Range on Protein: 520-799
Range on HMM: 34-306/308.0
KIYNkipGTSNNGLEEEFKKLTSIKIqNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIpvkrgEENTDYVNASFIDGY--RQKDSYIASQGPLLHTIEDF
....    ... .|||||..|.|.|. . ......||.|..|||   |.||. .||..     .|..||.|||..|||  ...  .|| |||| .|.|||
llek...aldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgPlpntvedF

WRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD---GLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIA
|||.||...  |||||.|.|.|.||||||||..   | . ||..||.|..||....|||| | .||.....||....||...||. |.|.. . ..... 
wrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfle

AVQKQQqqsGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA
.|.|..   ...|| |||||| ||||||.|| ..||....|| .|||..|| || |||.||||.|||.|.|....||.  .  ..
lvrksl...pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklkltkl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 520-796 4.2e-101 333.2 In-house 12-287 (319) alignment 
Range on Protein: 520-796
Range on HMM: 12-287/319.0
KIYNKIPGTSNNGLEEEFKKLTSIkiQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWR
. ....  |....||.|||.|     .||.... . . | ||||  .|..|.  ||...   | |..||.||||||||.... .|| |.|| .|||||||
erlkalastgetllekefkllkea..vndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWr

MIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTREN-KSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK
|.|| .|  .||||.| |... |. .|||.   ..|| ..|.|..||| | | .|.| . .  .. ..|.. .|..  ||. ..| ...... ..  ..|
mvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirk

QQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFS
 .... . ||.||||||.||||||..|. .||||| ||.||||.||. ||.||. |||. |||.|.|... |...|..
srektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 520-788 1.4e-32 107.5 In-house 13-286 (310) alignment 
Range on Protein: 520-788
Range on HMM: 13-286/310.0
KIYNKIPGTSNNGLEEEFKKLTSIKIQNDKMRT-GNLPANMKKNRVLQIIPYEFNRVIIPVKRGEeNTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFW
 . | |  | . |.|   |.   .  ..|   |      .|.|||  ...  .  || . . .     ||. | ..     ....| ||||| ||| |||
alenfiiateklgieglvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrstficsqgplqhtiidfw

RMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLV-SYGDITVElKKEEECESYTVRDLLVTNTREN----------KSRQIRQFHFHGWPEVGIPSDgK
|||.. .. ||..|    | |. ||  |||| |.  .|| | |  .  |  | . . .| ||   .|          |  ..   ..  ||. |.| . |
rmifqeraesilllckvgeegrpkcvgywpslgvtetygcirvt.nlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpde.k

gmisIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVV
      .  |.   |    |  |||||| .|... .||   .....    .|. . .  |. .|   .||  || .  .| 
....chtvpqrllaqvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 522-801 1.7e-82 271.6 In-house 11-287 (287) alignment 
Range on Protein: 522-801
Range on HMM: 11-287/287.0
YNKIPGTSNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPvkrgEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMI
 .| . ..|.| .. |. | ... ..|..  .  . | .|||. ||.... .||..     .|. ||.||.|||||..|  .|....|. .|. .||..|
vakghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkli

WEWKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTR-ENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQ
.. .   ||||....|  .|.| ||||..  |..|. ..|| .||  ..|..|.| |.|.  ... .|..|...  |.. |  .. . .. .|    |.|
ddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq

QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYANF
...|| .| ||||.. ||...|||  | ....| ||..|||| .|| | |.|..||| |||.| ...|.||.|.|. |..|
rkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfetysdf
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 523-793 6.3e-88 289.5 In-house 13-280 (288) alignment 
Range on Protein: 523-793
Range on HMM: 13-280/288.0
NKIPGTSNNGLEEEFKKLTSIKiQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIW
.|   ....|..||...|.... ....  .|.|. | ||||  .|.||...|| .     |...||.|||.|||...|  |||.|||| .|..|||....
akksarnrtgfseeynsLaale.ktksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvy

EWKSCSIVMLTELEERGQEKCAQYWPSDGL-VSYGDITVELKKEEECESYTVRDLLVTntRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ
| |.  ||||||| |.|..|| .|||...  . ||..||.|....| |....| ||.   .... ..| |... .||. |.| . . .. ..  |. ..|
enktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanq

QSgNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
.    ||.|||||| |||||| || .....|..|  .||. ||. || ||. .||||.||||.|.|. . |.
ad.tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslie
0036941 (Phosphotyrosine protein) phosphatases II 524-792 6.1e-98 323.0 In-house 6-277 (297) alignment 
Range on Protein: 524-792
Range on HMM: 6-277/297.0
KIPGTSNNGLEEEFKKLTSIKIqNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIpvkrGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWE
... .....|..||..|..... . ......||.|..|||   |.||...||..    ..|..||.|||..|||..|  .|| |||| .|.||||||.||
lekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

WKSCSIVMLTELEERGQEKCAQYWPSD--GLVSYGDITVELKKEEE--CESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQ
... .|||||||.|.| ||||||||..  . . |||.||.|...|.  ...||.| | ||.|....||....||..|||. |.|.. . ....| .|.|.
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkv

QQQS-GNHPITVHCSAGAGRTGTFCALSTVLERVK---AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
.... ...|. |||||| ||.|||.|. ..|....    || .|....||.|| |||..|||||||.|.| ...|..
lkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
subfamily_Ptp69D_pd Subfamily Ptp69D 524-793 2.8e-88 291.0 In-house 15-287 (307) alignment 
Range on Protein: 524-793
Range on HMM: 15-287/307.0
KIPGTSNNGLEEEFKKLTSIKIQNDkMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWE
.  . .. ||..|..|| . .|. .  ....   |  |||  .|.... .||....  |.|..||.||||| ||..| ..||.|.|.  ||.||||||.|
srkrdtdfglakeyekLeareidks.tkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiae

WKSCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTR-----ENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK
 ..  ||||..|.|  ..|||.||| .  | |||| |.| .||... |. |.| |...      ...||.. |.|. ||... .|   .|.. .|  |..
qevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvre

QQQQSgNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
 .... . ||.||||||.||.|.| ||. .|...|||  .|.|.||| || ||. .|| ||||.|.|. . .|..
lykln.rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 527-794 2.5e-81 267.9 In-house 11-278 (281) alignment 
Range on Protein: 527-794
Range on HMM: 11-278/281.0
GTSNNGLEEEFKKLTSIKIQNDKmRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKS
  .|.|. ||..||..| ..|   .  . ..|..|||   |. |.  || .  .  ..||||.||.|..||...  |||.|||. .....||.|.|| | 
qndnaGfieeyeklaaigvdnta.taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkv

CSIVMLTELEERGQEKCAQYWPSDG-LVSYGDITVELKKEEECESYTVRDLLVtNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGN
. |||.|.  | |. || .||| |   ..|||.||. ..||| ..|  | . . .......|...|...  ||. |.|.. | ...  ..|.| .... .
saivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltekktk

HPITVHCSAGAGRTGTFCALSTVLERVKAE-GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA
.|. .||||| |||||. || .....|.||   ||| ..|..|| .|  ||||. |||| ||.| ...| 
aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
0047943 (Phosphotyrosine protein) phosphatases II 528-792 2.1e-98 324.4 In-house 9-272 (273) alignment 
Range on Protein: 528-792
Range on HMM: 9-272/273.0
TSNNGLEEEFKKLTSIKIqNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIpvkrGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSC
.....|.|||..|.|.|. . ......||.|..|||   |.||. .||..    |....||.|||..|||..|  .|| |||| .|.||||||.||... 
lgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvr

SIVMLTELEERGQEKCAQYWPSDG---LVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQS-
 |||||||.|.|.||||||||..|    . ||..||.|..||....|||| | .||.  ..||....||..|||. |.|.. . ....| .|.|..... 
viVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealp

GNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
.|.|. |||||| ||||||.|| ..|.....|| .||...|| || |||.||||.|||.|.|... ||.
sngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 528-795 4.1e-91 300.3 In-house 19-286 (305) alignment 
Range on Protein: 528-795
Range on HMM: 19-286/305.0
TSNNGLEEEFKKLTSIkiqNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSC
.|..|||...|.|..    ....  |.  || .|||. .|......|.|.  |  ....||.|||..|||..|..||..|||| .|..||||.|.| |  
ysdkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvs

SIVMLTELEERGQEKCAQYWPSDGLV--SYGDITVELKKEEECESYTVRDLLVTN-TRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG
.|||||.| | |..|| ||||        .|...|||| |.. . |. |.| ...   ...||.. |...  ||. |.|     ..|.|  |||.|... 
tivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkkdk

NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF
. |..|||||| ||||.|.|..  |||.|.|...|||. .| || .|. |||||.|| |.. ...|.| ..
gvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 528-798 1.7e-81 268.3 In-house 17-289 (290) alignment 
Range on Protein: 528-798
Range on HMM: 17-289/290.0
TSNNGLEEEFKKLTSiKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEEN--TDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWK
. |.| ...||.| |   .. .. .|. . | ..||  .|..|. ||...  . |...   .|.||..|.||..| .||| |||. .|. |||..||. |
kgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqek

SCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRE-NKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG
.. |||||.  | |..|| ||||. .  .|| ....| .||....|. | | |.|... ...... |...  |.. |   . ......|. ..|.| ..|
vtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyktqrkrg

NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDY
|..| ||||.. ||...|||. | ....| ||  |||| .||.| |.| .||| .||.. ...| .|.| |. |
ntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsfety
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 528-800 6.2e-69 227.0 In-house 12-301 (301) alignment 
Range on Protein: 528-800
Range on HMM: 12-301/301.0
TSNNGLEEEFKKLTSIKiqNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRG--EENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWK
. .|..||..|.|.. .  ....  |   .| . ||  .| .|. ||.|.  |.     ...|.|||.||||..|  .||.|||. .|. ||||.||. |
khsnkfeeqykelkege..dksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqek

SCSIVMLTELEERGQEKCAQYWPSDGL--VSYGDITVELKKEEECESYTVRDLLVT-----N----------TRENKSRQIRQFHFHGWPEVGIPSDGKG
  ||||.|.|.|. ..|| ||||.      ..| .||.|..|    ....|.| |.     |          .....|... |..   ||. |.  . . 
pvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprt

MISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYAN
.. .|  | ..||. |  |. ||||.. .|.|..|..|  || .||||. |||| .|..| ..| .|.||||| . |.|...|.   | |||
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylqlnstyan
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 528-792 2.5e-57 189.3 In-house 17-279 (439) alignment 
Range on Protein: 528-792
Range on HMM: 17-279/439.0
TSNNGLEEEFKKLTSIKIQNDKMRT-GNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKS
  .. ..|.|.|. |.. .   . .      .  |||  .. .... ||..    |   . |.|| .|.|| ... |||.|||  .| .||||...| |.
nkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekkt

CSIVMLTELEERGQekcaqYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRE--NKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG
  |||||.| |  .     |||||. | ||||.|   .. |   |..| . | | |.  .| | . |||.  ||.  .|..   ..  . |..  ...  
vtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkee

NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
  |. |||||| |||||  ||   ||..|.|  .|.   || || || .|||.| || | |. | | |
ygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 528-608 4e-15 49.8 In-house 20-95 (95) alignment 
Range on Protein: 528-608
Range on HMM: 20-95/95.0
TSNNGLEEEFKKLTSIkiQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRgeeNTDYVNASFIDGYRQKDSYIASQG
 |.. ...||| ..          .|   ||. |||.|.|.||.  ||..  ||   ..||.|| |.||| .|. |||.||
nsdqefdnefksismt..sgapytvgsseanipknrflnifpydatrvvlttkr...dsdyinacfvdgyarkncyiaaqg
0040438 (Phosphotyrosine protein) phosphatases II 529-792 2.3e-99 327.9 In-house 16-276 (317) alignment 
Range on Protein: 529-792
Range on HMM: 16-276/317.0
SNNGLEEEFKKLTSIKIQndKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCS
....|.|||..| |.|.    .....||.|..|||   |.||...||.. .  | ...||.|||..||...|. .|| |||| .|.||||||.||.....
dftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtv

IVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQqSGNHPI
|||||||||.|.||||||||... . |||.||.|..|||....|.| | |.......||....||..|||. |.|.. . ..... ||..... ....|.
ivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreale.dpggpv

TVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
 |||||| ||||||.|. ..||... || .||...|| || |||..|||.|||.|.|....||.
lVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 529-790 8.2e-77 253.2 In-house 22-277 (315) alignment 
Range on Protein: 529-790
Range on HMM: 22-277/315.0
SNNGLEEEFKKLTSIkiQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCS
..||...... .     |   ... .   | .|||  .||.|.  || .|.   ....|||||.||||| .|. |||.|||.  ...||||...| .   
tkngfkqdyesipgg..qlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigk

IVMLTELEERGQEKCAQYWPSDgLVSYGDITVELKKEEECESYTVRDLlvTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGnHPI
|||||.| |. ..|. .||| .  | || ||| .|.||  . |||| |  . . ... |.. |.|.  ||..|.|     .. .|  |.. ...|   .|
ivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsv.gai

TVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE
 |||||| ||||||..|..||....|| ..||.. .. .| .| .|||..|||.| |... |
vvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 529-790 5.4e-68 223.9 In-house 4-264 (283) alignment 
Range on Protein: 529-790
Range on HMM: 4-264/283.0
SNNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPvkrgEENTDYVNASFID---GYRQKDSYIASQGPLLHTIEDFWRMIWEWK
..|. .  ...|  . . . .        | .|||  .|.|.. .|| .      |. ||.||.||     |.|.  ||..|.|| .|. |||.|... |
rvnnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelk....sesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdek

SCSIVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSR-QIRQFHFHGWPEVGIPSDGKGMISiIAAVQKQQQQSG
 ..|||||.| |  ..||.||||..| . ||. || |.||   .|.... ||. .    ||   .  . . .| |.|  .    ..  .  |. .|..| 
itaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvk.fnkvislqtesk

NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE
. || ||||.| |||..|.|.|. .. ...| ..|||..|| .| ||. .||||.|| . ...| |
kgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 529-792 1.1e-31 104.8 In-house 20-287 (305) alignment 
Range on Protein: 529-792
Range on HMM: 20-287/305.0
SNNGLEEEFKKLTSIKiQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIpvkRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCS
. .|| .||. .  .. . .||..     . .|||  ..   . ||| .   .|    .|. | ..    .   .| .| || .|  ||| | .. |  .
gpaglraefvamkrfn.dfekmkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkvea

IVMLTELEERGQEKCAQYWPSDG--LVSYG--D--ITV------ELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIaav
| || .| |.| .||..|..|.    ...   .  |.|      .|| ......   .  || .   .|.|.. ..|.  ||. |.|.    .. ..   
ifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailell...

QKQQQQSGnhPITVHCSAGAGRTGTFCALSTVLERVKAEGILD-VFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
.| .   |  ||.|||||| ||||.   |  .|... |  |..   . .. .| ||   .|| .|| | ..|. .|.
ekarpskg..pivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_PTPN12_pd Subfamily PTPN12 530-793 1.3e-79 262.1 In-house 7-278 (290) alignment 
Range on Protein: 530-793
Range on HMM: 7-278/290.0
NNGLEEEFKKLTS--IKIQNDK---MRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEW
.. ...||.|| .   | ...|     .|. . |.||||   |.||...|| .  ...||. ||.||.|| |  .| .|||.|||| .|..|||||||| 
eeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiwek

KSCSIVMLTELEERGQEKCAQYWPSDG--LVSYGDITVELKKEEECE-SYTVRDLLVTNTreNKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ
.   .||. .. | |. ||..|||. |   . .|...|.|..|. ..  ...| | |..   ..||...|||.. ||. |.||  | ....|..|.. |.
nveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqe

qSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
 | ..|. |||||| ||||| .|.  | | .||| |   ||||. | .|| ||. .||| ||||. || | |.. 
.sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_PTPN23_pd Subfamily PTPN23 530-793 8e-67 220.1 In-house 14-281 (288) alignment 
Range on Protein: 530-793
Range on HMM: 14-281/288.0
NNGLEEEFKKLTSIKIQNDK-MRTGNLPANMKKNRVLQIIPYEFNRVIIPvkrgEENTDYVNASFIDGYRQ-KDSYIASQGPLLHTIEDFWRMIWEWKSC
. .|...||.|.. . .. . . .     . .|||   |.||. ||| .     ... ||.||||. .      ..||.|.||  |. |||.|..| || 
ktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkss

SIVMLTELEERGQEKCAQYWPSD--GLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK---QQQQ
 ||||.. ||.|..|...|||.|    |..||..| ||...| | .  |.| ..  .... ....  ... |||.|.|.  . .. .. .|..   ..|.
viVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqr

SGNHPITVHCSAGAGRTGTFCALSTVLERVK-AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
  . |. |||||| ||||.|. . .... ..  .|.||. | |. || || .|||. ||..|.|..| |.. 
ksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar
subfamily_PTPRN_pd Subfamily PTPRN 530-794 1.2e-64 212.9 In-house 28-294 (297) alignment 
Range on Protein: 530-794
Range on HMM: 28-294/297.0
NNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFI-DGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCS
.. ||.|.. |.. . ..    ... . |.||||. ...||. .|| .  .  .|..||.|||.| |   .. .|||.|||| .|. |||.|.||  .. 
kdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvv

IVMLTELEERGQEKCAQYWPSDGLVSYGDITVELKKEE-ECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQsGNHP
||.||.||| | ..|..||| .|   |.   |.|  |   |. | || . . | . ...| . ||||  ||| |.|.  | ..     |.|  .     |
ivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrG.rscp

ITVHCSAGAGRTGTFCALSTVLERVK-AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA
| ||||.||||||.....  ||.|..     .|.  |.. || |||..|.| .|.||....| | ..|
ivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevna
0049772 (Phosphotyrosine protein) phosphatases II 530-795 2.9e-47 157.3 In-house 18-283 (314) alignment 
Range on Protein: 530-795
Range on HMM: 18-283/314.0
NNGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEfNRVIIPvKRGEENTDYVNASFIDGYrqkDSYIASQGPLLHTIEDF----------WR
 ..|. ... .. . ...  . ...|..|..||| |.|.|.. ||||.| . . ...|| |||..||.    ..||.|||| .|..||          ||
llklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilp.glpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwr

MI--WEWKSCSIVM---------------------LTELEERGqekcaQYWPSDGLVSYGditvelkkeeecesytvrdlLVTNTRENKSRQIRQFHFHG
|.  .....  |||                     |..| ..|      ...   |  .                      ... .|  .|.. ... . 
mvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....neptaadlellk....................eelydpelferlgikylrip

WPEvGIPSDGKGMISIIAAVQKQqqqSGNHPITVHCSAGAGRTGTFCALSTVLERVkaeGIlDVFQTVKSLRLQRP-----HMVQTLEQYEFCYKVVQEY
.|  | . . . . ........    . ..|. |||.|| ||||||...  .. .    |. .. .... .||.||     .....||||||......||
vpD.gsaplledfdeflefieea...dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealley

IDAF
.. .
lkfl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 530-792 4.9e-28 92.4 In-house 25-285 (302) alignment 
Range on Protein: 530-792
Range on HMM: 25-285/302.0
NNGLEEEFKKLTSIKIQNDKmrTGNLPANMKKNRVLQIIPYEFNRViipvKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTI---EDFWRMIWEWKS
.  ...||||. ..|.. .|       .|.|||.  ..  .. |.|    | ..|. .||||| ..    . | | .| | . .    |.||||... | 
taevkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlv....kleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqeki

CSIVMLTELEERGQeKCAQYWP--SDGLVSYGDITVELKKEEECESYTvR----DLLVTNTREnkSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVqKQQ
 |.|.|   ||  .    ...|  |.  . ||.. |  .| |. |  .      ..|  .  .  |  .   ... |..  .|     .|  .| |  ..
vsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsn..svlanvyvltnWkqkkvpvkyaeliktaakv.fak

QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
........ .    |||| |.| .| ...|.....    . ..|||.| |||..|..|.|| . | ..  ||
kikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 531-793 1.8e-50 166.4 In-house 6-260 (267) alignment 
Range on Protein: 531-793
Range on HMM: 6-260/267.0
NGLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEentdYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIV
  .|.||.... |  .. .. .     | ..||. . .||. .|||.  |  |    |.|||...||..|  .|. |.||  || ||. .| . |   ||
ceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpviv

MLTEleeRGQEKCAQYWPSD--GLVSYGDITVELKKEEECESYTVRDLLVTnTRENKSRQIRQFHFHGWpevGIPSDGKGMI-SIIAAVQKQQQQSGNHP
.||     ....  ..||        | |.|||   |.| . | .  | .   ... ....  .... |    | .. |  .  ... . |.| . ||.|
lltk...vftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelk.fknesahnvtlyyykkw...nintnnkpylkplfgilaknqlengnrP

ITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
. |.||.| ||.|||  . . |||.| ||..|.|. .. .| ||. .|.|.|.| ...... || .
lvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 532-800 2.2e-108 357.1 In-house 21-288 (318) alignment 
Range on Protein: 532-800
Range on HMM: 21-288/318.0
GLEEEFKKLTSIKIQNDKMRTgNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVM
 |.||...|.  . .  .... . |.| .|||   |..|.  || .  . |||..||.||..|||||.| .|||.|.|| .||||||||.|| .|. |||
llseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivm

LTELEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVH
||..||||..|...||||.|  |||...||||.| |...|..| . ||.| |..|||.||.|.  ||. |.|..| ......  |.| ||.||..||.||
ltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivvh

CSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYAN
|||| ||||.|.|....|||.|||...||||||| || ||. |||| .||||.|.|..|.. ..  ...
CsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevd
0046845 (Phosphotyrosine protein) phosphatases II 532-799 1.4e-100 331.6 In-house 1-281 (284) alignment 
Range on Protein: 532-799
Range on HMM: 1-281/284.0
GLEEEFKKLTSIKIQND-KMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGE-ENTDYVNASFIDGY-----RQKDSYIASQGPLLHTIEDFWRMIWEW
||||||..|.|...    ......||.|..|||  .|.||. .||.. .  |. |..||.|||..|||     ..|  .|| |||| .|.||||||.||.
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

KSCSIVMLTELEERGQEKCAQYWPSDG-LVSYGDITVELKKEEECESYTVRDLLVTNTR-ENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQ
..  |||||||.|.|.||||||||..|  . |||.||.|..||....|||| | .||.  ...||....||...||. |.|.. . ..... .|......
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-SGNHPITVHCSAGAGRTGTFCALSTVLERVKAEG---ILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYA
 .|..|| |||||| ||||||.|| ..||....||    .||...|| || |||.||||||||.|.|....||.  .  ..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 532-799 1.5e-89 295.5 In-house 35-299 (319) alignment 
Range on Protein: 532-799
Range on HMM: 35-299/319.0
GLEEEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVM
 || ||.... . ..  ..   ||. |  |||. .|.... |.| .    ||| .||.||||..||..|| |||.||||  |..||||||||.....||.
klevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivl

LTeleergQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTN-TRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK-QQQQSGNHPIT
||      ..||.|||| .. . ..   |...  ||.. |.|||. ... ..|.  |.|.|||| |||.|| |  .  .. ..  |.. .... ....| 
lt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhraniv

VHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE-YIDAFSDYA
||||||.||||.. .| ..|.|.| |  .||...|. || ||...|| | || |.|  . | .. ..|| |
vhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 532-792 1e-69 230.2 In-house 24-288 (325) alignment 
Range on Protein: 532-792
Range on HMM: 24-288/325.0
GLEEEFKKLTSIKIQNdkMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKsCSIVM
|.  ||. | |   .   ...  .|.|..|||   ..... .||..  |. . ..||.|||..  ...|| ..|.| || .||.|.||.. .|. ||.|.
gfahefgllpsddgia..kkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWr.csvvv

LTELEERGQEKCAQYWPSD--GLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQ-----QSG
...  . |...||.||| .    . .| . |.|.  ||   |  | | | .... ..| ..||.. .|...| .     .|||.  |.. ..       .
vlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantka

NHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
  || |||||| ||||.| .| ..|..|  |  .|.|. || || .|| ||.| .|| ..|. . |..
stpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 532-792 1e-37 124.8 In-house 17-277 (307) alignment 
Range on Protein: 532-792
Range on HMM: 17-277/307.0
GLEEEFKKLTsiKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKrgEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVM
 | .||..|.  | . . . .  . || .|||  ..   . .|... ..     .||. | ..    .   .|..||||  |. .|| |. . |  |..|
alvdefrvla..kktpegvtveafsantdknryqdvkcqdkgrivvkfd..glasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvim

LTELEERGQEKCAQYWPSD-G-LVSYGD----ITVE------LKKEEECesYTVRDLLVtnTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQ
| .. | .. || |||| . |    .|.    |.|.      |  .|..    | .| |     .||| |... .. ||. |.|    . | .. ||. .
lckvielakikceqywpleegqklvfgeapntisvanlgakklapdedl..invttlkv..dwaqksrtiqhlqwenwpdrgvpqinltainlleavryd

QqqsgnHPITVHCSAGAGRTGTFCALSTVLERV-KAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
.      |. |||||| ||.||  |.| | ... . .   |. . |. || ||.. .||  || . ..|. || 
t.....npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
DSPc_SM00195 533-792 2.6e-93 307.5 In-house 2-262 (263) alignment 
Range on Protein: 533-792
Range on HMM: 2-262/263.0
LEEEFKKLTSIKIQNdKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVML
|.|||.|| . . .. ...... ..|..|||  .|.||. .||... . ..|..||.||..|.|...| .||| |||| .|.||||||.|| |.  ||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TELEERGQEKCAQYWPSD--GLVSYGDITVELKKEEECE-SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSgNHPIT
|| ||.|.|||..|||..  |   .|.|.|.|...|... ....|.| .|.. ....|...|.....||. |.|.. | ..... ||.|....| ..|| 
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
|||||| ||||||......|.....|  .|.|..||.|| |||.|||||||| |.|... |||
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 533-792 2.6e-93 307.5 In-house 2-262 (263) alignment 
Range on Protein: 533-792
Range on HMM: 2-262/263.0
LEEEFKKLTSIKIQNdKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVML
|.|||.|| . . .. ...... ..|..|||  .|.||. .||... . ..|..||.||..|.|...| .||| |||| .|.||||||.|| |.  ||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

TELEERGQEKCAQYWPSD--GLVSYGDITVELKKEEECE-SYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSgNHPIT
|| ||.|.|||..|||..  |   .|.|.|.|...|... ....|.| .|.. ....|...|.....||. |.|.. | ..... ||.|....| ..|| 
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkksksts.sgpiv

VHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
|||||| ||||||......|.....|  .|.|..||.|| |||.|||||||| |.|... |||
VhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 533-793 5.9e-70 230.5 In-house 7-269 (274) alignment 
Range on Protein: 533-793
Range on HMM: 7-269/274.0
LEEEFKKLTSIKiqndKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEEN-TDYVNASFIDGYRQK-DSYIASQGPLLHTIEDFWRMIWEWKSCSIV
||.|| .| .      ...  ... . .|||  .|.| |  ||..  . .|.. ..|.|| .| ||...   |.| |||| .|..||||||.. ..  ||
lekeflelPlnf....dqeeldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MLTELEERGQEKCAQYWPSDGLV----SYGDITVELKKEEECESYTVRDLLVTNTREnkSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNH
|||.|.|. ..|||.|.| .  .     |||. .. .|  |.. |.|| |.. .. .  .|..  . .  ||.   | | . ...... |....... ..
mltklkeaneqkCavyfPdaedyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenak

--PITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
  |. |||||| |||| | | |  . ....|...||...|  |||.|  |||| ||||. .... .|  
lapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_CG42327_pd Subfamily CG42327 533-717 1.1e-39 131.0 In-house 7-191 (319) alignment 
Range on Protein: 533-717
Range on HMM: 7-191/319.0
LEEEFKKLTSIKIQNDkmrtgNLPA-NMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQK-DSYIASQGPLLHTIEDFWRMIWEWKSCSIV
. |||..|  .  . |     ..|.   .|.||....|    ||. . .  .... |..||.. ||..   ||||.| .|  .  ||||..|| .|  ||
vaeefrdlPqliarad.....evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrviv

MLTELEERGQEKCAQYWPS----DGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFhGWPEVGIPSDGKGMISIIAAVQ
 ||.| | | ..||.|.|.    |.  .|||| | ||. |  . | .  ||. .  ...||..  . .  |.| ..|.. . .|...  |.
qltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_ptpA1_pd Subfamily ptpA1 533-750 5.3e-36 119.2 In-house 23-254 (418) alignment 
Range on Protein: 533-750
Range on HMM: 23-254/418.0
LEEEFKKLTSiKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDsYIASQGPLLHTIEDFWRMIWEWKSCSIVML
..|||. |    .   .   |.   |  |||  .|.| .. || .   . .| .||.|| .|||   |. .|..||||  || |||||.|| .   ||||
ikeefrllee.svgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq.fictqgplpntiadfwrmvwenrcriivml

TELEERGQEKCAQYWPSD-----------GLVSYGDITVELKKEEEcesYTVRDLLV---TNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK
.   |  . || .||| .           |   .|  .||| .  .      |...      | | ..|.| |... |||.  ||   . .  .. .. .
sresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviq...dpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitn

QQQQ-----SGNHPITVHCSAGAGRTGTFCALSTVLE
.|.|       | || |||||| |||||||.   ...
rqnqiipssdrnvpiivhcsagvgrtgtfctavimmk
subfamily_PTPN13_pd Subfamily PTPN13 534-791 1.8e-66 219.3 In-house 14-268 (273) alignment 
Range on Protein: 534-791
Range on HMM: 14-268/273.0
EEEFKKLTSIKIQnDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGeentdYVNASFIDGYRQKDS--YIASQGPLLHTIEDFWRMIWEWKSCSIVM
.||||.|  .| . |. ..|.  .|..|||  ...||.  ||..  . |     |.|||.|    .||   |||.|||| .|..|||.|.|| |.  |.|
aeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviam

LTELEERGQEKCAQYWPSD---GLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQqsGNHPI
.|   |.|. || .|||.     |. .. ..||| | .. ....||.| |.... ..||.. ...|  ||. |.||  . .. ..| |.. |.   . ||
vtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt..dagPi

TVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY
 |||||| ||.||. .. .||. .. .  .|| ..|..|| ||  .||| .|| |.||.. | 
vvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 534-789 6.2e-51 168.0 In-house 23-233 (392) alignment 
Range on Protein: 534-789
Range on HMM: 23-233/392.0
EEEFKKLTSIKIQNDkmRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLT
 |||. | . .| ..  .... . |.||||  .|.||. .||.. |     ..||.|||.|... .. .|||||||   ...|||||... . ..|.|.|
feefhdlpgpdiypq..tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvt

ELEERGqekcaqywpsdglvsygditvelkkeeecesytvrdllvtntRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQsGNHPITVHCS
.|.|                                            . .. | . ||||  ||. ..|     .. .|  |. .  |   ||. .|||
klkegd..........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGq.ythpliihcs

AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQ
|| ||||   .. .|. . |   ..|||. |  .| .||.|||| ||| | |  | 
agvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavl
subfamily_PTPRA_pd Subfamily PTPRA 535-792 6.5e-138 454.1 In-house 36-302 (330) alignment 
Range on Protein: 535-792
Range on HMM: 36-302/330.0
EEFKKLTSIKIQNdKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTE
|||. | . .||.  . . .   |..||||..|.||.|.|||..||.|.|..||.||||||||..||..||.|||. .|.|||||||||.||..||||||
eefnalPagpiqa.tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmlte

LEERGQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVT----NTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNhPITV
|.|| .||||||||..|||.||.|.||...|.....||||..||.    .|||.|||..|||||..||.||.|....||......|.|..|||.. ||.|
lkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag.pivv

HCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY-------I
|||||.||||||..|..||||||||...|||..||.||||||.||||.|||||.|||..||       .
hcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdtel
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 535-799 8.7e-88 289.5 In-house 2-263 (284) alignment 
Range on Protein: 535-799
Range on HMM: 2-263/284.0
EEFKKLTSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTe
 ||.... . ..  ..   ||. |  |||. .|.... |.| .    ||| .||.||||| ||..|| |||.||||  |..|||||||| ....||.|| 
vefrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.

leergQEKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTN-TRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK-QQQQSGNHPITVHC
     ..||.|||| .. . ..   |...  ||.| |.|||. ... ..|.. |.|||||| |||.|| |  .  .. ..  |.. .... ....| |||
.....kdkcsqywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhc

SAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE-YIDAFSDYA
|||.||||.. .| ..|.|.| |  .||...|. || ||...|| | || |.|  . | .. ..|| |
sagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdva
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 535-792 3.9e-74 244.3 In-house 23-277 (315) alignment 
Range on Protein: 535-792
Range on HMM: 23-277/315.0
EEFKKLTSIKIQndKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTE
|||. |   .|   . |..  . |.||||   |.|.. .||.. |   . . ||.|||.| .. .  .||||||||  ...|||||... |  .|||.|.
eefhdlpdPdiy..rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtk

LEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTVRDLlVTnTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQqQQSGNHPITVHC
..|  . ||.||||     .| .| | ||| . | .   ..| | ||  . ..||.. ||.|..||. |.. .   .. .| .|. . ... .... |||
kqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vt.rkseesrtvtqfqftewPdkGvdkqtssllklikevkad.ngkkefsllvhc

SAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
|||.|||| ....  |....| .  .|||..|| || .||..||| |.| | | .|.|..
saGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 535-793 4.2e-71 234.5 In-house 30-285 (297) alignment 
Range on Protein: 535-793
Range on HMM: 30-285/297.0
EEFKKLTSIKIQNDKMRTGnlPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQkdSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTE
|||. | . .||.. .       |..|.|   |.||...||.. .   . . |||||||. |...   .|..| |   |..|||.|... .   ||||..
eeflclpeaniqpqtvaek..kvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnd

LEERGQeKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPS--DGKGMISIIAAVQKQQQQSGNHPITVHC
..|| . |||.||. .| ...||..|.|.  .|.| .  |.| ||. .  . | ..|..|  ||.  ..   . . .. .|  |.|. .|  . |. |||
dnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhc

SAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
.|| |||| ....  |. ..| |  .|.|..|| || .||..||| |||.| |..| |.. 
laGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleall
subfamily_PTPN14_pd Subfamily PTPN14 535-793 1.7e-60 199.5 In-house 27-297 (300) alignment 
Range on Protein: 535-793
Range on HMM: 27-297/300.0
EEFKKLTSIKIqNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEeNTDYVNASFIDGY--RQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVML
 |. ...  .  . .. |..|| | .|||. ...||| ||| .   . . .|.|.||| |      .. |||..|||| .|..|||.|.|| .   ||||
teyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivml

TELEERGQEKCAQYWPSD----GLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQK---QQQ----
|| || |.||. .|.|..      | .|   |  |  |. .|.. . | .     .. |..  . .  ||. |.|.| ||..| .  ||    . .    
teeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseve

-QSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
 .. . |. ||||||.||||       ... .. .  .|. .... || || ..|||| ||.| |||. .|..
skeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_CG7180_pd Subfamily CG7180 541-795 2.6e-64 211.7 In-house 25-293 (296) alignment 
Range on Protein: 541-795
Range on HMM: 25-293/296.0
TSIKIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQ
.  ...... ..|    |..|||  ...||..|||...   |||..||.||...|.. .|  ||  ..|  .|...|||.... .. ..|.||.  .  .
ltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak

eKCAQYWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNT----------RENKSRQIRQFHFHGWPE-VGIPSDGKGMISIIAAVQKQQQQS----GN
 .. .||| ..   ||.| ||. .|..    . | . .| .           . . | ...|..  |.    .|.  ...| ..  |.. ...      .
.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpee

HPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF
 |. |..| ||.|.| ..|.   || |. |. .|||. || || .||..|.. |.| ..| |..|.. ..
gPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_PTPN3_pd Subfamily PTPN3 544-793 1.3e-66 219.4 In-house 27-277 (280) alignment 
Range on Protein: 544-793
Range on HMM: 27-277/280.0
KIQNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIpvkrGEENTDYVNASFI----DGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERG
| .. .. . ..|.|..|||   |.||.  ||..     |..|||.||...    ..  .   |||.|||| .| .|||.|.|| ||  |||||.| |||
kkpglaisaarkpenlsknryrdilpydatrvkl....kesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverG

QEKCAQYWPSD-GLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQqQSGNHPITVHCSAGAGR
. || ||||.    ..||...|...||.| .|| .|.|..........|.| |. .  ||. |.|.| . .....  |.|.. .. ..|. |||||| ||
rvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklr.sgkeePvvvhCsaGigr

TGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEF-CYKVVQEYID
|| . .| | |  . |.  . . . |. .| ||  .||| .||.| |  ... | .
tGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkvyee
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 544-788 8.2e-22 72.7 In-house 5-255 (290) alignment 
Range on Protein: 544-788
Range on HMM: 5-255/290.0
KIQNDKMRTGNLPANMKKNRVlQIIPYEFNRVIIPVKRGEENTDYVNASFIDgYRQKDSYIASQGPLLHT-------IEDFWRMIWEWKSCSIVMLTELE
. ... ..|  .  . ...|. ..   | .||.. .     | ||. |...  . .    |..| |. ..       ||.|| |. . |. ..||| | |
estavllktdyvkkhemdqRl.evpLveatrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefe

ERGQE----KCAQYWPS--DGLVSYGDITVELKKEEECESYTVRDLLVTNTrENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQqqsgnHPITV
|. ..     ||.| |   .. . ....||. |. |. .   .| |.|.   ...  ..    ..|| .. .. | | ..|.|  |....      |. |
eksantslfaCakYvpesvgeelkfkgltvkCkskekeddvetRelvvkfd.deeeftvtHsllkgWnklnvqedtktllsliqkvkask.....tpviv

HCSAGAGRTGTFCALSTVLERVK-AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVV
||  |  |  .. |.      .   .| . . . .|.|| || ..... ... |   ..
HcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagi
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 545-702 1.2e-17 58.4 In-house 83-235 (244) alignment 
Range on Protein: 545-702
Range on HMM: 83-235/244.0
IQNDKMRTGNLPANMKKNRVLQIIPYEFNRViiPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERgqekcA
 .   |.    | |  |||    .|..||||  |. .|     |.||||.    .   || .| ||  |  |||.|. | .   .|.|  .||       
pdpsvmkdafnpnnswknregaglpfdfnrv..plskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....d

QYWP-SDGLVSY-GDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGI
.||| |. |  |  |||| |   .|       .| .    ..  . .  |    ||  | 
eywpdseplewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_PTPRD_pd Subfamily PTPRD 546-798 8.5e-115 379.5 In-house 36-287 (564) alignment 
Range on Protein: 546-798
Range on HMM: 36-287/564.0
QNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQ
|. .... | ||| .|||. .|..|. .||..   .|.|..||.|||||||||.. .|||.|||| .||||||||.|| .|..|||||.|||.|..||..
qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchk

YWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQqQSGNHPITVHCSAGAGRTGTFCAL
|||..|  .||..||.|..||| . |..|.. ........||..|||||  ||. |.|  .......|  |.. . .....||.|||||| ||||||...
YWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvraln.epdagPivVhCSaGVGRTGtfivi

STVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDY
. .|||.|.|. .|..|.|| || ||..|||| ||| |......|....... 
damlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnte
0045098 (Phosphotyrosine protein) phosphatases II 546-792 2.4e-87 288.1 In-house 21-272 (278) alignment 
Range on Protein: 546-792
Range on HMM: 21-272/278.0
QNDKMRTGNLPANMKKNRVLQIIPYEFNRVIipvkrgeentDYVNASFIDGYrqKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQ
..... ..... |..|||  .|.||...||.          ||.|||.||||  .. .|| |||| .|..|||||.||... .|||||||.|.|.|||||
ipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPSDGLVSYGDITVELKKEEECESYTVRDLLVTNT----RENKSRQIRQFHFHGWPEVGIPSDG--KGMISIIAAVQKQQQ------------QSGNHP
|||..| . |||.||.|..||... ||.|.|||||.     ...|| ....|...||. |.||.   | .....  ... ..            .....|
ywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

ITVHCSAGAGRTGTFCALSTVLERVkaEGILDVFQTVKSLRLQRPH-MVQTLEQYEFCYKVVQEYI
. |||||| |||||..|. ..||..  || .|....|| || |||. .||.||||.|.|....|..
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 546-795 6.1e-38 125.1 In-house 25-272 (281) alignment 
Range on Protein: 546-795
Range on HMM: 25-272/281.0
QNDKMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEE-NTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCA
  |   . | | | |||| |.|   .  || . ||  ..  |||. | .|     |  || .|||   |  |||||||. .. .|||| .. |  .||||
psdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekca

QYWPSDGLVS--YGDITVELKKEEECESYTVRDLlvTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQqqqSgnHPITVHCSAGAGRTGTF
.|.| .  .   .  ..|. .     .|     |    . | ..| | .. .. ||.  .|   . |. |.  .. .   |   |  .||||| ||.||.
eyfprnahcclqfdklsvsyedstvnkslvttrl..nlsyegetrlithwlwkewpdwqvpessevmlkilrkirar...s..tppvihcsagvgrsgtl

CALSTVLERVKAEGIL-DVFQTVKSLRLQ-RPHMVQTLEQYEFCYKVVQEYIDAF
 |.   |. ...   | |. | |  ||.  |   ||||.|| . .||. ..  |.
maveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldfgvay
subfamily_PTPN1_pd Subfamily PTPN1 548-791 6.6e-57 187.4 In-house 22-270 (290) alignment 
Range on Protein: 548-791
Range on HMM: 22-270/290.0
DKMRTGNLPANMKKNRVLQIIPYEFNRVIIpvKRGEEntDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYW
 ..|. .||.| ..||   . ||.  |...  .|..   ||.|||...  . | ||| .|||| .|.. ||.|.|| || ..||| .. |..| ||||||
fptreaklpenrnlnryrdvspydhsrikl..eradn..dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PSDGL---VSYG--DITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNH-PITVHCSAGAGRTGT
|..     . .    ..|.| .||. . |||| | ..| . ...|.| .||.  ||. |.|.    ... .  |..    | .. |  .||||| ||.||
PqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaGiGrsGt

FCALSTVLERVKAEGI---LDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY
|| . |.| ......    .|. ...  || .|  ..|| .| .| |  . | 
fclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileG
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 548-710 4.8e-29 96.2 In-house 23-187 (297) alignment 
Range on Protein: 548-710
Range on HMM: 23-187/297.0
DKMRTGNLPANMKKNRVLQIIPYEFNRVIipVKRGEENTDYVNASFIDGYRQ--KDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQ
... . . .. ..|||  .|. .. .||   ..|.  ..||.|| ..    .  .  || .||||  |..|||....|     |||...|.| |..||| 
esfssakrnsslrknryrdilatddtrvk..llrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcap

YWPS--DGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMI
||||  ..    ||. ||   .   |  .|    ..    ..||..|   | .||. |.||| . . 
ywpsvvqerlkagdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlv
0040439 (Phosphotyrosine protein) phosphatases II 549-792 4e-89 293.7 In-house 2-246 (249) alignment 
Range on Protein: 549-792
Range on HMM: 2-246/249.0
KMRTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWP
......||.|..|||   |.||...||.. . .| . .||.|||.||||..|. .|| |||| .|.||||||.||... .|||||.|.|.|.||||||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

SDGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQS-GNHPITVHCSAGAGRTGTFCALST
..| . |||.||.|...|....|||| | .||. ...||.........||. |.|.. . ....| ||.| ...   ..|. |||||| ||||||.|. .
lggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

VLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
.||... |. .|....|| || |||..||..|||.|.|....|..
mleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 549-794 5.4e-63 207.5 In-house 8-266 (270) alignment 
Range on Protein: 549-794
Range on HMM: 8-266/270.0
KMRTGNLP---ANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQ-KDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCA
.. . .||    . | ||  .|.|    ||...  . ...| |.|| .. |. . | .|||..|||  |...||||||| |. .|||.|.|||.|..||.
etsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCe

QYWPSDG----LVSYGDITVELKKEEECESYTVRDLLVTntRENKSRQIRQFHFHGWPEVGIPSDGK------GMISIIAAVQKQQQQSGN-HPITVHCS
.|||..      ...|.|.|   .||  | | .. | ..  .. ..|..  |... ||. |.|..         ......||......  . .|. ||||
rYWpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcs

AGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDA
|| |||||. || .... .. .. .|| . .. || .|. .||. ||||| ||.|.||.. 
aGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 549-793 4.1e-54 178.3 In-house 29-278 (287) alignment 
Range on Protein: 549-793
Range on HMM: 29-278/287.0
KMRTGNLPANMKKNRVLQIIPYEFNRVIIpVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWP
 ... .  |..||||  ...|.. .||.. .. ||  .||.|| .. .|......||.|||.  |. ||||...| .|.|....|   | .. || .|||
tfkaaeelaavkknryadvlPiddtrvll.saegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywP

SDGL-VSY-GDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAV----QKQQQQSGNHPITVHCSAGAGRTGTF
     .   |   | |...     |.|| | . .   ...| ..|...  ||. ...    |.|  .  |    . ... |.  |. ||...|.||.|..
erevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGil

CALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
 |. ....| .  | .|| ..|  || .|  .||.  |. . |. .  |  
latlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk
0037934 (Phosphotyrosine protein) phosphatases II 550-792 4.5e-79 260.7 In-house 2-242 (243) alignment 
Range on Protein: 550-792
Range on HMM: 2-242/243.0
MRTGNLPANMKKNRVLQIIPYEFNRVIIpvkrgeENTDYVNASFIDGYrqkDSYIASQGPLLHTIED----FWRMIWEWKSCSIVMLTELEERGQEKCAQ
.....||.|..|||.  |.||...||..      |..||.||..|...   . .||.|||| .|.||    ||||.||... .|||||||.|.|.|||||
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPsDGLvSYGDITVELKKEEECESYTVRDLLVTNTR-ENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQ-------SGNHPITVHCSAGAG
||| ..   |||.||.|..||....|||| ||..|.  .. .|.....|...||. |.|.. . ..... .|.. ...       ....|. |||||| |
ywp.gev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvg

RTGTFCALSTVLERVkaeGiLDVFQTVKSLRLQRPH-MVQTLEQYEFCYKVVQEYI
||||..|. ..|...   | .|....|| || |||. .|||..||.|.|....|..
RtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
0042113 (Phosphotyrosine protein) phosphatases II 551-792 2.1e-89 294.4 In-house 2-243 (245) alignment 
Range on Protein: 551-792
Range on HMM: 2-243/245.0
RTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD
....||.|..|||  .|.||...||....  |.. .||.|||..||||... .||.|||| .|.||||||.||... .||||||.||.|..|||||||..
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLE
. . |||.||.|..|| ...|||| | |||.....||.....|...||. |.|.. . ..... .|.|......|.|. |||||| ||||||.|. ..||
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

RVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
....|. ......|| || |||..|||..||.|.|....|..
qlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_egg_pd Subfamily egg 551-791 1.4e-24 81.3 In-house 33-269 (307) alignment 
Range on Protein: 551-791
Range on HMM: 33-269/307.0
RTGNLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERgqEKCAQYWP--
.|     |..| |  ..   .. || . ..||    |.. |  ..|    . .| .| ||  | .|||||... .   |||||   |   |.|  |||  
ttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpka

-SDGLVS-YGDITVELKKEE-EC-ESYTVRDLLVTNTRenksrqIRQFHFHGW-PEVGIPSDgkgMISIIAAVQKQQQQSgnHPITVHCSAGAGRTGTFC
 || ||   | . .|  | . .    ..|  | .  .         . .   |  .|   ||   . | .  ..| .. |  .|. |..  |  ...|. 
esdslvtvpGslrienlkvdskadplfrvtklklvGgd......deerflehwqgdvnnssd...vysplrvlrklrnls..kpvvvqdilGvskaatlv

ALSTVLERVKAEGIL--DVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY
|. . |  .    |    | ..|. |||.|.  |..  .| | |..|  .
aieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlff
subfamily_eak_pd Subfamily eak 551-704 2.1e-19 64.1 In-house 45-196 (332) alignment 
Range on Protein: 551-704
Range on HMM: 45-196/332.0
RTGNLPANMKKNrVLQIIPYEFNRVIIPVKRgEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD
. ..   ....| |..|.||... | .   .  ..  |.||| ..       || .  .    .  ||.|. | || .||.| |  | . ||  .|.| .
setarleavnrn.vvkivpydrylvrltssq.lnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdk

G--LVSYGDITVELKKEEECESYTVRDLLVTNtrENKSRQIRQFHFHGWPEVGIPS
.   ...| . || |.  . . . .| | ..    |.. ..  ....|| |. .| 
treelkfGildverkefvkrniletrllelsk..GnethrvlhykvfGwtettlpk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 552-792 4.3e-23 76.4 In-house 41-279 (303) alignment 
Range on Protein: 552-792
Range on HMM: 41-279/303.0
TGNLPANMKKNRVLQIIPYEFNRVIIpvkrgeENTDYVNASFIDGYRQKDSyIASQGPLLHTIEDFWRMIWEWK-SCSIVMLTELEERGQEKCAQYWPSD
  ..  ||.|||  ..|  .  .| .       .. |. ||...   .| . | .| || ||  |||.|| | |  | ...||. |         .   .
knqfvknmdknrfvdvicldhskvkl......sdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnq

GLVSYGDITV---ELKKEEECESYTVRDLLVTNTReNKSrQIRQFHFHGWPEVGIPSDGK-GMISIIAAVQKQQ-QQSGNHPITVHCSAGAGRTGTFCAL
 .. . . ..   |.|. |  . .... | |.|    ||  .   |.. ||   |||||   ..  |  .|    . | ..|      .| ||.|||. .
dflkfeersirvgefkrvelgdgwvlkvlsvsngd.yks.flhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalf

STVLERVKAE-GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
 |    ...|   ||. . .. .|  | | || | |. . | .. |..
etahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 554-800 5.5e-95 312.3 In-house 5-250 (250) alignment 
Range on Protein: 554-800
Range on HMM: 5-250/250.0
NLPANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEkCAQYWPSDGLV
. |.| .|||  .||...  ||..  ..|....||.||||..||......||.|||| .||||||||..| || .|||||.|.| ... . |||| ..  
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvekae

SYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVK
 |||.||.|...||   ||.| | .........|..||.||  ||. |.|   . .. ..  ||..|||.|| |. |.|||| ||.|.|.|...||||.|
kyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavlerlk

AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAFSDYAN
 | ..|||. .| || .|||.|..|||| |.|.......|...|||.
kekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsvedyar
subfamily_PTPRK_pd Subfamily PTPRK 557-790 2.6e-81 267.9 In-house 42-275 (314) alignment 
Range on Protein: 557-790
Range on HMM: 42-275/314.0
ANMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLVsYG
 | .|||. .|..|.  ||.. .  |. ..||.||..||.|..   .|. |||| .|..||||.... ...|||||||| | |. || .||| |. | ||
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.yg

DITVELKKEEECESYTVRDLLVTN--TRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQsGNHPITVHCSAGAGRTGTFCALSTVLERVKA
|| ||| . |  . . || . |..     .. |..|||.| |||. ..|   .|...... |.|.|.. .. .| |||||||||||||.|...||. .. 
dikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqee.eaGrivvhCsaGaGrtGtfiaidivldmier

EGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE
||..|||..||.|| ... ||.| ||| |.| |. |
egvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 557-795 5.8e-41 135.0 In-house 53-286 (290) alignment 
Range on Protein: 557-795
Range on HMM: 53-286/290.0
AN--MKKNRVLQIIPYEFNRVIIpvKRGEeNTDYVNASFIDGYrqKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD--GL
.|  .||||  ...  .  |||.  | |  . ||| | ...|   |  .| .||.|  |. |.|||. . |   |||| || | |. ||.||.|      
kntefkknrykdvvcndktrvil..kdGy.dGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGev

VSYGDITVELKKEEECESYTV-RDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKqqqQSGnhPITVHCSAGAGRTGTFCALSTVLER
...|.|||   .|.. .. .. . | | .  . |. ... ..   ||.  ..     .. .. ...|    ||  |..|||||| |||||| |. . |. 
ltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk...asG..pvvvhcsaGiGrtGtfvaievglqi

VKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF
.     ||. ..|..||  |   ||   ||    ... ..  .|
lldGkeldlldlvralrnsrlnsvqvdiqylalveilldlGkdf
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 557-792 2.9e-34 113.4 In-house 34-270 (285) alignment 
Range on Protein: 557-792
Range on HMM: 34-270/285.0
ANMKKNRVLQIIPYEFNRVIIpvKrgEENTDYVNASFIDG-YRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD--GLV
||   ||  ..   |  ||..  |  . . ||. ||..    ... .||..||||  |. |||.||.. | . ..||  | | | |||| |.|     .|
anpdlnryadvrcieetrvvl..k..nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgevv

SYGD--ITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHF--HGWPEVGIPSDGKGMISIIAAVQKQQQQsgNHPITVHCSAGAGRTGTFCALSTVL
 .|   ||.   |||      .  | |.|| .  |  .   |     ||.   | | . || .   |.| . .  ..|| |||||| ||| ||  .    
kfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpk..ekpicvhcsagvgrtatfvgidyat

ERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
 |.  .  ..... |. .|  | . ||.  |. | | |. ||.
irimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 557-792 1.4e-32 107.9 In-house 42-271 (288) alignment 
Range on Protein: 557-792
Range on HMM: 42-271/288.0
ANMKKNRVLQIIPYEFNRVIIPvkrgEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSD--GLVS
||  ..|  ..   .. || .     ..   |..|  .   . |   | .| ||  ||| .|.|. |     ||||.|| |.|.|| |.|.||     . 
anptrdryenlprcditrvkls....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekar

YGDITVELKKEEECESYTVRDLLVTNTRENKSRQ-IRQFHFHGWPEVGIPSDGKGMISIIAAVqkqqqQSGNHPITVHCSAGAGRTGTFCALSTVLERVK
.| .    ||. .    .|.  |. ...| . .. ... |.. |.. |.| . .  . ..  .     .| ..|| ||.|||.|||||.     .|| ..
igrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl.....kslqkPivvhssaGvGrtgtlililialeslr

AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
 .  | . . ...|| .| . .||  || . ...| |..
lddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 557-792 1.6e-32 107.4 In-house 52-289 (305) alignment 
Range on Protein: 557-792
Range on HMM: 52-289/305.0
A--NMKKNRVLQIiPYEfNRVIIPVKRGEeNTDYVNASFIDGYR-QKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS---D
|  .. |||  .. | . .. .. ...    .||. | ..      .  .|..|||| .||..|| |. . |   ||||    | |. |||||||    .
adiaitknryqdv.pcq.dqsavkldkps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

GLVSYGDITVELK---KEEECE-SYTVRDLLVTNTrENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQqqsgnHPITVHCSAGAGRTGTFCALS
 |   . | ||     |  | .    .  | .| .  ...  .|....  ||. |.|      . ...|..  .      || |||||| |||||  |. 
klelksgivvenvsgskpmerdaeiqitllnltys.gdqkmsvrhlqwtewpdrgvppckltslellsairgsk.....vpivvhcsagigrtgtivaie

TVLERVKAE-GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
 .||..  .     . . ||.|| || . .|.  || | ..|. .|.
yilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 557-650 7.8e-13 42.6 In-house 33-124 (332) alignment 
Range on Protein: 557-650
Range on HMM: 33-124/332.0
ANMKKNRVLQIIPYEFNRVIIPVKRGEEntDYVNASFIDGYRQKDSYIASQGPLL-HTIEDFWRMIWEWKSCSIVMLTELEERGQEKcAQYWPSD
 ||  ||. ..  ....|| .  . |..  |. |||..||| .| .|| .| |.  ||   ||||. | |   |... ...|. . | | |  ||
nnmdmnriphlycfdhsrvelapqdgkd..dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrk.apydisd
Y_phosphatase Protein-tyrosine phosphatase 558-790 3.1e-89 293.8 Pfam-A 1-235 (235) alignment 
Range on Protein: 558-790
Range on HMM: 1-235/235.0
NMKKNRVLQIIPYEFNRVIIpvKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWP--SDGLVSY
|.||||  .|.||...|| .  |  |...||.||....||..| ..||.|||| .||||||||.|. |. .|||||.|||.|.||||||||  ... ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDITVELK-KEE-ECESYTVRDLLVTNTRENK-SRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQqQSGNHPITVHCSAGAGRTGTFCALSTVLERV
|||.|||| ||. ....||.|.| .... |.. .|...|.|...||. |.|.. |.....| .|.|.. .. ..|..||||||.||||||.||...||..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE
.||. .||.|.||.|| |||.|||.||||.|.||...|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 558-790 3.1e-89 293.8 In-house 1-235 (235) alignment 
Range on Protein: 558-790
Range on HMM: 1-235/235.0
NMKKNRVLQIIPYEFNRVIIpvKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWP--SDGLVSY
|.||||  .|.||...|| .  |  |...||.||....||..| ..||.|||| .||||||||.|. |. .|||||.|||.|.||||||||  ... ..|
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslty

GDITVELK-KEE-ECESYTVRDLLVTNTRENK-SRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQqQSGNHPITVHCSAGAGRTGTFCALSTVLERV
|||.|||| ||. ....||.|.| .... |.. .|...|.|...||. |.|.. |.....| .|.|.. .. ..|..||||||.||||||.||...||..
gdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkveksk.eaksgpvvVhCsaGvgRtgtfvaldilleql

KAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE
.||. .||.|.||.|| |||.|||.||||.|.||...|
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 558-792 2.9e-72 238.4 In-house 43-276 (515) alignment 
Range on Protein: 558-792
Range on HMM: 43-276/515.0
NMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSY
| ||||   |.||. .||.. |   . . ||.|||.| ..    .|||||||.  ...||||.... .   |.|.|.|.|  . ||..|||      | .
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

GDITVELKKEEECESYTVRDLLVtnTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGnHPITVHCSAGAGRTGTFCALSTVLERVKAE
| | |||   | |   . | | |  .....|| . ||||..||. |.| . . .. .| .|. ...|   ||. .|||||.|||| ....  |. ..|  
Gsikvelvsleactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqyt.hpliihcsaGvGrtGvvisidsvvahaktt

GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
 ..|||..|. .| .||..||| ||| | | .|.|..
rmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 558-788 8.1e-56 183.9 In-house 3-235 (237) alignment 
Range on Protein: 558-788
Range on HMM: 3-235/237.0
NMKKNRVLQIIPYEFNRVIIpvKRGEENTDYVNASFIDGYRQ-KDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS-DGLVSY
|  |||  .|. |. .||..  |    ..||.||....|.     .|||.||||  . .|||.|.|. |   ||||| | |. ..|| .|||| |   .|
nkiknrygnivaydhsrvvl..kgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GDITVELKKEEECESYTVRDLLVTNTRENK-SRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQ-SGNHPITVHCSAGAGRTGTFCALSTVLERVK
| .|| |||.||   |||| ||...  . |  | | |..|  ||. |.|     .. .   . .. .  |   |  .||||| |||| |  . ..| . |
gvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqak

AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVV
 . ..|... |.|.  .||...|| .|| | ....
ekkvvdiynyvysieedrpyiiqtkdqyvfihqti
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 558-789 2.4e-53 175.8 In-house 7-237 (239) alignment 
Range on Protein: 558-789
Range on HMM: 7-237/239.0
NMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQ-KDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPsDGLVSYG
|  |||  .|. |...||..     .  .||.|||..  |     .|||.|| .  .  |||||.|. . | ||||| | |  ..|| |||| |    | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstskyc

DITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQqQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEG
.. | |.| |    | .| .....  . . | . |.||  ||. |.|     .. .   . |.    | .|  .||||| ||||.|  . ..| . | . 
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrtgaflvidamlrqakkqk

ILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQ
 .|.|. ||..| .||||||| ||| | .  | 
tvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 558-788 2.7e-53 175.6 In-house 8-237 (239) alignment 
Range on Protein: 558-788
Range on HMM: 8-237/239.0
NMKKNRVLQIIPYEFNRVIIPVKRGEENTDYVNASFIDGYRQ-KDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPsDGLVSYG
|  |||  .|. |...||..     .  .||.|||..  |     .|||.|| .  .  |||||.|. . | ||||| | |  ..|| |||| |    | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstskyc

DITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQqQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEG
.. | |.| |    | .| .....  . . | . |.||  ||. |.|     .. .   . |.    | .|  .||||| ||||.|  . ..| . | . 
nlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkds.lpgarpwvihcsagvgrtgaflvidamlrqakkqk

ILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVV
 .|.|. ||..| .||||||| ||| | .  |
tvdifnyvkairedrphmvqtseqyvfihlav
0041856 (Phosphotyrosine protein) phosphatases II 558-792 2.4e-50 166.0 In-house 1-171 (182) alignment 
Range on Protein: 558-792
Range on HMM: 1-171/182.0
NMKKNRVLQIIPYEFNRviipvkrgeeNTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTeleergqekCAQYWPsdglvsygd
|..|||.  |.||...|          . ||.||....|..  . .|| |||||.|..||.||..|..  .||.||         . .|||         
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.........

itvelkkeeecesytvrdllvtntrENKSRQIRQFHFHGWPEVGIPSdGKGMISIIAAVQKqqqqsGNHPITVHCSAGAGRTGTFCALSTVLERvkaeGi
                         |.  |.. |.....||  |.|.    ....| .|..      ..|. |||||| |||||..|.  ....    | 
.........................ellerlgiqylylpwpDhgvpd.ldelldfieevle.....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.

LDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
......|| .| .||.||.|..|| |.. .. |..
vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 558-667 9.2e-23 75.5 In-house 47-167 (350) alignment 
Range on Protein: 558-667
Range on HMM: 47-167/350.0
NMKKNRVLQIIPYEFNRVIIP--------VKRGEENTDYVNASFIDGY----RQKDSY--IASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKC
 . |||  .|.||| .||...        .|   .  ||.||...       ... ..  || |.||  |..||...| . |   |..||.. | . |||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

AQYWPSdglVSYGDITVELKKEEE
 .||.     || |||| |.   |
yrYWqe...gsydditvklaskwe
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 558-634 8.8e-08 26.0 In-house 37-118 (347) alignment 
Range on Protein: 558-634
Range on HMM: 37-118/347.0
NMKKNRVLQIIPYEFNRVIIPV-----KRGEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTE
...|||  .    .  ||..        | ..   |.||| |     .  || .| || .|. |||.|.   |   .| . |
slsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 559-666 1.8e-11 38.0 In-house 49-169 (349) alignment 
Range on Protein: 559-666
Range on HMM: 49-169/349.0
MKKNRVLQIIPYEFNRVIIPVK--------------RGEENTDYVNASFIDGYR--QKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEK
. |||  .|.|||  ||...                 .    ||.|| ..   |   .  ||| | ||  |..||...|   .   .. |.. .| . ||
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CAQYWPSdglVSYGDITVELKKEE
| .||      || .||| |.   
cdiywqe...lsysnitvklqnss
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 568-701 1.8e-10 35.2 In-house 3-125 (130) alignment 
Range on Protein: 568-701
Range on HMM: 3-125/130.0
IPYEFNRVIipvkrgeeNTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERgqekcAQYWPSDGLVS-Y-GDITVELKKE
...|..|.         . .|.||||.    .   |. .| ||  |  |||.|. |     .|.|  .||       .|||    .  |  ||.| | . 
lefevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtltdr

EECESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVG
.| .      | . .   .  . .  |.   ||  |
defknikasnleiesdlneshqaltmfqisnwpsdg
0044763 (Phosphotyrosine protein) phosphatases II 569-791 1.9e-36 120.7 In-house 1-170 (178) alignment 
Range on Protein: 569-791
Range on HMM: 1-170/178.0
PYEFNRVIIPVKRGEENTDYVNASFIDGYrqkdSYIASQGPllhtiEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDGLvsygditvelkkeeec
|....||...  .|.| .|| |||.|...     |..|..|     .|......|..  .||.|||  |.|..|| .|||..                  
pldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

esytvrdllvtntrenksrqiRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQqSGNHPITVHCSAGAGRTGTFCALSTVLERvkaeGIlDVFQTVKSLR
                      |... ..|  | |.  . .  ....... .. . ..|. |||||| ||.||..|.  ....    |. .... .. .|
.....................iqylhipipDhgvpdllehflefvefieeald.ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvr

LQRPhMVQTLEQYEFCYKVVQEY
 .|| .|.. .|....|.. ...
erRp.ivpnpgqlrqLyefelrl
0046846 (Phosphotyrosine protein) phosphatases II 580-792 1.4e-44 147.2 In-house 6-173 (176) alignment 
Range on Protein: 580-792
Range on HMM: 6-173/176.0
KRGEENTDYVNASFIDGYRqkdsYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSdgLVSYGDitvelkkeeecesytvrdllvt
   ... ||.||..|.|.|    .|| |||| .|..||..|..|..   .|.|||. | |. ||..|||   | ..|                       
lgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi......................

ntrenksrqirQFHFHGWPEVGIPSDgKGMISIIAAVQKQQQQSgnHPITVHCSAGAGRTGTFCALStvleRVKAEGILDVFQTVKSLRLQRP-HMVQTL
           |.....||. |.|.. . ..............   .|. |||||| |||||..|.      .. |  |.|..... .| ||| ..||| 
...........qylhlpwpDhgvpdl.elllellefirealkeg..gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtp

EQYEFCYKVVQEYI
|||.|.|.......
eQyrflyefellll
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 581-794 1.9e-23 77.7 In-house 63-278 (312) alignment 
Range on Protein: 581-794
Range on HMM: 63-278/312.0
RGEENTdYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS-DGLVSYGDITVELKKEEECE-------SYT
 |.||  |. | |.    . . ....||||  |.  ||..     |.||..|. . | | ||||.|     |.|   |  |  .   | |         |
agdenf.yihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkit

VRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQqsgnhPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRP
 | | |      .  .. .. .  ||. |.|        ...||.|...     |.  ||||| |||||.. . ...  ..     .| ..   || .| 
hrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdkk.....pviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdra

HMVQTLEQYEFCYKVVQEYIDA
  |... || .. ..| |.. .
rsvrvfpqyvyalrcvleflys
0043147 (Phosphotyrosine protein) phosphatases II 582-786 1.4e-44 147.2 In-house 1-155 (172) alignment 
Range on Protein: 582-786
Range on HMM: 1-155/172.0
GEENTDYVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELeergqekcaqywpsdglvsygditvelkkeeecesytvrdllvTNT
|.|..||.|||..|.|.  |..|| |||| .|..|||||..|..   ||.||||                                           ...
gdegsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lyd

RENKSRQIRQFHFHGWPEVGIPsDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLervkaEGIlDVFQTVKSLRLQRPHMVQTLEQY
.|. .|.. |.....||  | | . . .....  ... ...| ..|. |||||| |||||..|.  .|     .|. .....|. .| .||..||. .||
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsqy

EFCYK
 |.|.
rflyy
0051429 (Phosphotyrosine protein) phosphatases II 586-795 7.6e-59 194.8 In-house 4-228 (272) alignment 
Range on Protein: 586-795
Range on HMM: 4-228/272.0
TDYVNASFIDGYRQ---KDSYIASQGPLLHTIEDFWRMiWEWKSCSIVMLTELEERGQEKCAQYWP------------SDGLVSYGDITVELKKEEECES
..|.||....|| .   .. ...|.||| .|..||||. .|..  .||.|...||||..|| .|||            |.  ..||...| | .|| .. 
sgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellld

YTVRDLLVTNT-RENKSRQIRQFHFHGWPEVGIPSDGkgMISIIAAVQKqqqqsgNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILD--------VF
|..| ||.|..   ...|.....|...||  |.|..   ..........      ..|. |||||| .||||..||  .|..| .| |.|        ..
yilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld......ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyle

QTVKSLRLQRPHMVQTLEQYEFCYKVVQEYIDAF
..|. || |||..||| |||.|.|....|.....
eaveelraqrpgavqteeqylflyeallellrsl
0036282 (Phosphotyrosine protein) phosphatases II 586-786 3.9e-51 168.5 In-house 2-164 (174) alignment 
Range on Protein: 586-786
Range on HMM: 2-164/174.0
TDYVNASFIDGYRQKDSYIASQGPLLhtiedFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSdglvsygditvelkkeeecesytvrdllvtnTRENK
.|| |||..|...  . .||.||||      ||.|..|... ..|||.|..|.| .|| .|||.                               .||  
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...............................lredl

SRQIRQFHFHGWPEVGIPSDGKgMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKaEGILDVFQTVKSLRLQRPHMVQTLEQYEFCY
.| . |... .||  | |.. . ..... .|.. .......|. |||||| |||||..|.  .| . . |.  |....|..||||||.|||| .||.|.|
erlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrfly

K
.
y
0051082 (Phosphotyrosine protein) phosphatases II 586-788 1.7e-38 126.9 In-house 3-149 (151) alignment 
Range on Protein: 586-788
Range on HMM: 3-149/151.0
TDYVNASFIDGYrqkdsYIASQGPllhtIEDFWRMIWEWKSCSIVMLTELEERGqeKCAQYWPSDGlvsygditvelkkeeecesytvrdllvtntrenk
.|| |.|...|.     ...|.||     .||.....|..  .||.|...||||  .|..|.|. |                                  
sdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg..................................

sRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKqqqqSGNHPITVHCSAGAGRTGTFCALSTVLERvkaegiLDVFQTVKSLRLQRPHMVQTLEQYEFCY
 ..........||. |.|   . ..... ....     .|.|. |||||| |||||..||  .|..      ........ .||.||..||. .|. |..
.ievlhipildwpdpglplsfdavleflellld....kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

KVV
...
fal
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 588-781 2.6e-28 93.6 In-house 77-270 (301) alignment 
Range on Protein: 588-781
Range on HMM: 77-270/301.0
YVNASFIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPSDG--LVSYGDITVELKKEEEC--ESYTVRDLLVTNT-R
 . | .|.   . . .||.||||  | |||| |.  ..   ||||..  |. .|||..| |..    .  |  ....|..|    .. . | | |... .
PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstg

ENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQqqqsgNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQY
. ..| .  . .. |.. |.|     .  ..  |.|      ..|| |||||| ||. .| .   .  .|.|.  ... ...| || .| . ||| .| 
kfatrtvthyqysewtdrgvPkshaelfdlmelvkks.....ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsql
0049260 (Phosphotyrosine protein) phosphatases II 593-786 5.9e-41 135.0 In-house 1-144 (152) alignment 
Range on Protein: 593-786
Range on HMM: 1-144/152.0
FIDGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWpsdglvsygditvelkkeeecesytvrdllvtntrenksrqirQF
|||||...  .|| |||. .|..|||||..|..   |||||||.|.| .||.||.                                           |.
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi...........................................qy

HFHGWPEVGIPSDGKGMISIIAAVQKQqQQSGNHPITVHCSAGAGRTGTFCALSTVLervkaeGILDVFQTVKSLRLQRPHMVQTLEQYEFCYK
... ||  | |..   .. .. ...|  ... ..|. |||||| |||||..|.  .|        ......|. .| .||..|.. .|..|.|.
lhlpwpDhgvpdlsqlllflllfiekl.aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 595-678 4.9e-13 43.2 In-house 230-311 (440) alignment 
Range on Protein: 595-678
Range on HMM: 230-311/440.0
DGYRQKDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERgqeKCAQYWPSDG-LVSYGDITVELKKEEECESYTVRDLLV
.|| .|...||.| ||  |. ||||.. ...  .|.|| .|...    |. ||| .   |..| .||  |  |. .   || | .
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlel
subfamily_hpo-7_pd Subfamily hpo-7 598-788 6.4e-19 62.9 In-house 35-223 (263) alignment 
Range on Protein: 598-788
Range on HMM: 35-223/263.0
RQKDSYIAsqgpLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEEceSYTVRDLLVTNTRE--NKSRQIRQFH
..|..|.     |. ||. |...|   |.  .|||.. .| |.||| .|.|   |.   . ...|   |  .     .. | ...| .   | ...... 
krknlysl....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhys

FHGWPEVGIPSDGKGMISIIAAVQKqqqqSgnHPITVHCSAGAGRTGTFCALSTVLE------RVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKV
. ||.|.  | . . .. |. ....    |  ... ||||.| ||.  |    .|        .    . ||  . .. || .|.  ..|  |  |   .
ykgWiekndpelareilnilkvarn....s..kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilm

V
|
v
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 599-791 1.3e-19 65.3 In-house 33-220 (255) alignment 
Range on Protein: 599-791
Range on HMM: 33-220/255.0
QKDSYIAsqgpllhTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTVRDLLVTNTRENKSRQIRQFHFHG
.|..|.        |.. |...|   |.  .|||....| |.||| .|.|   |.   . |..|   |         .... | ..  | .... ....|
rknlysl.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykG

WPEVGIPSDGKGMISIIAAVQKqqqqSgnHPITVHCSAGAGRTGTFCALSTVLE------RVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE
|.|   | . . .  |. .|..    |  ... ||||.| ||. .|     |        .    . ||  . .. || .|.  ..|  |  |.  .| .
WieknaPelareilnilkvvrd....s..ksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld

Y
.
l
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 600-787 2.4e-27 90.4 In-house 4-199 (199) alignment 
Range on Protein: 600-787
Range on HMM: 4-199/199.0
KDSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTVRDLLVTN--TRENKSRQIRQFHFH
.  |||.| || .|. |||.|.||  |  |||. . .   .   . |||.   |   || ..|  |       ||.  |..||  |    .|.| .. | 
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqft

GWPEVGIPSDGK--GMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLE---RVKaEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKV
 | |   |      |..     | |. .|  . |. |||| | | || | ||   .      |   ..|.|.  | ||  |  .. .|..|.| |.|
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 601-787 2.8e-27 90.2 In-house 4-198 (198) alignment 
Range on Protein: 601-787
Range on HMM: 4-198/198.0
DSYIASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVELKKEEECESYTVRDLLVTN--TRENKSRQIRQFHFHG
  |||.| || .|. |||.|.||  |  |||. . .   .   . |||.   |   || ..|  |       ||.  |..||  |    .|.| .. |  
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPEVGIPSDGK--GMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLE---RVKaEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKV
| |   |      |..     | |. .|  . |. |||| | | || | ||   .      |   ..|.|.  | ||  |  .. .|..|.| |.|
wkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesk.tsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 605-783 5.5e-18 59.4 In-house 95-279 (302) alignment 
Range on Protein: 605-783
Range on HMM: 95-279/302.0
ASQGPLLHTIEDFWRMIWEWKSCSIVMLTELEERGQEKCAQYWPS--DGLVSYGDITVE-------LKKEEECESYTVRDLLVTNTRENKS--RQIRQFH
    |   |.| .| .| ... . .| |... | ...|||.|.    .| . .|  ||.       |..  . .|...  . ..|.. .|   . .  ..
kpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdila

FHGWPEVGIPSDGKGMISIIAAVQkqqqqSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEF
| .||. | | . .  . |.   .     |  . . |||||| |||||. |.   ..  . . . |. . |. .|  |   ||. .|  .
fsawpdhGapkeaytaldilkfce.....sykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliy
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 614-793 4.3e-08 26.1 In-house 131-310 (346) alignment 
Range on Protein: 614-793
Range on HMM: 131-310/346.0
IEDFWRMIWEWKsCSIVMLTELEERGQEKCAQ-YWPSDGLVSY-GDITVELKKEE---ECESYTVRDLlvtnTRENKSRQIRQFHFH-GWPEVGIPSDGK
.|||| ||.. .   .| |   ... ..  .  .   .|   | | . .. .. .   .   ||.  |       |    | | | |  |  .  |    
vedfwymiyqeq.ihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdpkeytievl....pegnsdsvicqvhhhapwkhlqqppktl

GMISIIAAVQKQQqQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYID
 .| .|     .. |  |  . |    |.||. .|      ....      .... .|... |||  |... ||   | .| .|| 
piikmihqflsek.qvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyia
0048076 (Phosphotyrosine protein) phosphatases II 655-791 7.4e-26 86.0 In-house 13-142 (145) alignment 
Range on Protein: 655-791
Range on HMM: 13-142/145.0
YGDITVELKKEEEC--ESYTVRDLlvTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQsgNHPITVHCSAGAGRTGTFCALSTVLErv
.|.... |. |. .    .|| .|  |...|. .|.. |... .||  |.|.. . .......... ...  ..|. |||||| |||||..|.  .|.  
lgslptaldlellkdlgittvlnl..tselellerlgiqylylpwpDhgvpdllellleflefieealke..ggpvlVHCsaGvgRtgtlvaaylmll..

kaEGiLDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY
  .| ........ .| |||..|.. .|..|.|....|.
..lg.vsleealelvrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 668-786 1.3e-23 78.7 In-house 28-139 (144) alignment 
Range on Protein: 668-786
Range on HMM: 28-139/144.0
CESYTVRDLLVTNTRENKSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQqsGNHPITVHCSAGAGRTGTFCALSTVLervkAEGiLDVFQTVKSL
   .|| .|  .   |   |.. |... .||  |.|.. . .......... ..   ..|. |||||| |||||..|.  ..     .| |....... .
lgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale..eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalv

RLQRPHMVQTLEQYEFCYK
| .||..|.. .|..|...
rsrrpgavpnpgqlrfLle
0038934 (Phosphotyrosine protein) phosphatases II 673-794 1.7e-10 36.3 In-house 60-179 (194) alignment 
Range on Protein: 673-794
Range on HMM: 60-179/194.0
VRDLLVTNTRENKSRQIR-QFHFHGWPEVG--IPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLErvkaEGIlDVFQTVKSLRL
| ||  |..  ....  .  .... .| ..   . . . . ... .|..  ... .. . ||| || |||||..|   .       |. .. . .. .| 
vidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr....lgm.saeeAialfre

QRPHMVQTLEQYEFCYKVVQEYIDA
 ||..... ...|  .| ..|...|
kRpgaipnqdyleallkrykelrka
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 685-791 4.4e-25 82.9 In-house 87-193 (440) alignment 
Range on Protein: 685-791
Range on HMM: 87-193/440.0
KSRQIRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFC
.|| ..|.|..|||. |.|     .. .|  |.. |...|| |. |||||||||||   |. ..|  .|    .|.|  ..|.| .||.|||| ||| | 
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

YKVVQEY
...| | 
heavleg
PTEN_1 686-775 4.7e-06 21.5 In-house 92-182 (196) alignment 
Range on Protein: 686-775
Range on HMM: 92-182/196.0
SRQIRQFHFHgWPEVGIPSDGKGMISIIAAVQKQQQQSGNHPITVHCSAGAGRTGTFCA-LSTVLERVKAEGILDVFQTVK-SLRLQRPHMV
 ..... ||. ..  | ||  . .  .  . .  .... .. . ||| || ||.|| .| .   ...  |.  |. ..      ... |.. 
ksgveylhfp.ieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqe
PTPc_DSPc_SM00012 689-789 8e-37 121.0 In-house 2-104 (105) alignment 
Range on Protein: 689-789
Range on HMM: 2-104/105.0
IRQFHFHGWPEVGIPSDGKGMISIIAAVQKQQQQSG-NHPITVHCSAGAGRTGTFCALSTVLERVKAE-GILDVFQTVKSLRLQRPHMVQTLEQYEFCYK
....|..|||. |.|.... ......||.|....|. ..|. ||||||.||||||.||...|.....| . .|.||.||.|| |||.||||.||| |.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VVQ
...
all
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 691-791 6.9e-15 49.6 In-house 219-343 (350) alignment 
Range on Protein: 691-791
Range on HMM: 219-343/350.0
QFHFHGWPEVGIPSDGKGMISIIA---------AVQKQQQQSGNHPITVHCSAGAGRTGTFCALSTVLE---------------RVKAEGILDVFQTVKS
|.... |.....  . . .....            ..  ...   || |||||| |||||...|  .|.                | |.    ....|. 
qlqvknWkDlslllnPesilqalevkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivne

LRLQRPHMVQTLEQYEFCYKVVQEY
|| ||  |||.|.|. |.|. .. |
lrkqrismvqnldqfifiYeallfy
subfamily_PTPDC1_pd Subfamily PTPDC1 691-787 1.4e-08 29.4 In-house 84-171 (182) alignment 
Range on Protein: 691-787
Range on HMM: 84-171/182.0
QFHFHGWPEVGIPSDgKGMISIIAAVQkQQQQSGnhPITVHCSAGAGRTGTFCALSTVLERVkaegiLDVFQTVKSLRLQRPHMVQTLEQYEFCYKV
 ..  ||.. | .|  . .. |.  |. .  | |   ..||| || ||||   |   |  .      |.  ...| .| .||. .|| || |.. . 
yvynfgwkDygvasl.eriLdivkvva.falqeg..kvavhChaGlGrtGvliacylvyakr.....ltaekaiklvrskrpksiqtreqvelvkef
subfamily_CG42327_pd Subfamily CG42327 719-792 2.7e-16 54.1 In-house 241-315 (319) alignment 
Range on Protein: 719-792
Range on HMM: 241-315/319.0
QQQQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAE-GILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
  ... . |..|||| |.||||.  |    .....     .|. |.| |.| .| . |.| ||||| |||..|| 
sgtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlseya
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 720-792 4.6e-11 36.6 In-house 260-344 (349) alignment 
Range on Protein: 720-792
Range on HMM: 260-344/349.0
QQQSGNHPITVHCSAGAGRTGTFCALSTVLE----------RVK--AEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEYI
 ...   .. |||||| ||||... |  .|.          ..|  |     .. .| .|| ||  ||| | |. ..|. . .|.
ldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 721-789 2.5e-15 51.1 In-house 224-292 (297) alignment 
Range on Protein: 721-789
Range on HMM: 224-292/297.0
QQSGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQ
..  | .. |||||| ||.|      ..|.... . | ||   .. || ||. .||||||.|..|..| 
emprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavl
subfamily_DSP23_pd Subfamily DSP23 723-785 2.1e-06 22.5 In-house 82-139 (148) alignment 
Range on Protein: 723-785
Range on HMM: 82-139/148.0
SGNHPITVHCSAGAGRTGTFCALSTVLERVKAEGildvfQTVKSLRLQRPHMVQTLEQYEFCY
. |  ..|||  | |||||. |   | ||  | .     ...  .| .||  |.|.|| .  .
ekneavsvhcllgrgrtgtmlacylvkerklaaa.....eaiaevrrlrpgsvetveqeklvr
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 729-788 8.3e-14 45.7 In-house 2-61 (69) alignment 
Range on Protein: 729-788
Range on HMM: 2-61/69.0
TVHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVV
 ||||.|.|||||| |.   . |.|.| ..|.|  |. .|  || ||    .| | .  .
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdal
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 730-790 7.3e-14 45.9 In-house 2-62 (69) alignment 
Range on Protein: 730-790
Range on HMM: 2-62/69.0
VHCSAGAGRTGTFCALSTVLERVKAEGILDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQE
||||.|.|||||| |.   . |.|.| ..|.|  |. .|  || ||   ..| | .  . |
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve
subfamily_ptpA1_pd Subfamily ptpA1 758-791 8.4e-07 23.1 In-house 364-397 (418) alignment 
Range on Protein: 758-791
Range on HMM: 364-397/418.0
LDVFQTVKSLRLQRPHMVQTLEQYEFCYKVVQEY
...|  |  || ||| ||| |||| |||| . . 
fnlfsivlklreqrpgmvqqleqylfcyktilde