Gene PTPRG in Homo sapiens

Synonym: HPTPG, PTPG, R-PTP-GAMMA, RPTPG, PTPRG

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRG
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP099_AA protein Get Run
HsapP099_AA_830-1121 phosphatase_domain Get Run
HsapP099_AA_1132-1412 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Carb_anhydrase Eukaryotic-type carbonic anhydrase 60-320 2.8e-62 197.3 Pfam-A 1-255 (256) alignment 
Range on Protein: 60-320
Range on HMM: 1-255/256.0
WAYSGAYGPEHWVTSSVSCGGRHQSPIDILDQYARVGEEYQELQLDGFDNESSnktWMKNTGKTVAILLKD---DYFVSGAGLPGRFKAEKVEFHWGHSN
|.|.   ..|.| .   .. |..||||.|  . |.. .. ..|.| . . ..     . |.|..| . |.|   .  .||. |.. ...... ||||.|.
WgyeeeaeeeewsklypiakgerqsPiniktkeakydpsLkplslsydeatak...eivnnGhsvqvelddssdksvlsggpleasyrlkqlhfHWgsse

gSAGSEHSINGRRFPVEMQIFFYNPDDFDSFQTAISENRIIGAMAIFFQVSpRDNSALDPIIHGLKGVVHHEKETFLDPFVLRDLLPAsLGSYYRYTGSL
 . ||||...| ....|. .  .|   ..|...|....  .  .... .|  . |..|. ..  |. . ...|.. |  | ...|||. |  |..|.|||
.ekGsEHtvdgkkyaaElHlvHwnsskyksvkeAvkkedglAvlgvllkvg.keneelqklvdaLeeiktkgksatltnfdpstllPk.lrdywtYeGsl

TTPPCSEIVEWIVFRRPVPISYHQLEAFYSIFTTEQQDHVKSveyLRNNFRPQQRLHDRVVSKS
||||..| | |||.. |. .| .||... | ........ ..   | .|.|| | |.|||| .|
ttPpleEsvtWivlkepikvsseqllklrslllsaegeeeve...lvdnyRplqpLkdRvvras
fn3 Fibronectin type III domain 348-429 9.4e-13 41.3 Pfam-A 1-79 (85) alignment 
Range on Protein: 348-429
Range on HMM: 1-79/85.0
SPPIHMKVQPLNQTALQVSWSQPEtIYHPPIMNYMISYsWTKNEDEKEKTFTKDSDKDlKATISHVSPDSLYLFRVQAVCRN
|.|  ..| . . | |..||| |.   . || .| . | ..|.. |..|.|| .....  .|...  |.. | |||||| ..
saPenlsvsevtstsltlsWsppk.dgggpitgYevey.rekgggeewkeftvprttt.svtltgLkpgteYefrVqavnga
0039614 (Phosphotyrosine protein) phosphatases II 817-1123 1.1e-95 315.7 In-house 3-292 (297) alignment 
Range on Protein: 817-1123
Range on HMM: 3-292/297.0
PIIPIPDDMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADmnitAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSkHSDYINANYVDGYN
|. .   ... ||.. .  ... .  |. ... ..|||..... |     .....||||.||||..||.|||||||| |..| |  .||||||.|||||.
plrdallesipiplsvldlllllekansktllllefeellslkpd....ysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgyd

K-AKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRrKCDQYWPTENSeEYGNIIVTLKSTKIHACYTVRRFSIRNtkvkKGQKgnpkgrqne
.  ...|||||||..|.||||||.|||.. .|||.|.|||.|| ||.||||.| . .||.. |||.... .. |||| ....|    .|.          
lltrkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....nges.........

RVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARM--PETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIH
| | ...|| |||.|||...  .| |..    |.   |. ||||||||||||||||.|... ||.|.. . .|.||  .|..| ||.. |||..||.|..
rtvthfqytgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfly

DALLEAILGK
||||| .. |
dallellkrk
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 822-1131 2.6e-72 238.5 In-house 4-295 (297) alignment 
Range on Protein: 822-1131
Range on HMM: 4-295/297.0
PDDMEAIPVKQFVKHIgelySNNQHgfSEDFEEVQRCTADMNITAEHSNHPE-NKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINANYVDGYNKakA
| . . ||. .|   .     .|.|  .. |.|  .|.   ||...   .   | .|.|| ||| || |||||. .   |.  |||.|| .| |...   
pkerrpiplsdfatlv....qknrh..tdvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaiv..nddpdsDyvnasfvkgnkh..r

YIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRrKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRntkvkkgqKGNPKgrqNERVVIQ
.|.|| | |.| .|||.|...... .|||.... |. . || .||. . . ..|.. |.|.|..    .  | ....        ||..|   ..||| |
littqmPmkatvadfWamvldeqvstivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevt........kgkak...arrvvkq

YHYTQWPDMGVPE-----YALPVLTFVRRSSAaRMPETgPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDA
|....|||  |..     . | ... || .      |. |.||||.||||||| .. |||.. ..|.. .|...|..|..| .| |||||.||| |.. |
yqfveWPdkaverkdsassllklisevrkdfs.qnaeg.PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyva

LLEAILGKETEVSSNQ
.|||.| ..|.. .. 
vleallsedtriqasy
0050432 (Phosphotyrosine protein) phosphatases II 823-1124 1e-104 345.4 In-house 21-303 (308) alignment 
Range on Protein: 823-1124
Range on HMM: 21-303/308.0
DDMEAIPVKQFVKHIGElySNNQHGFSEDFEEVQRCTAdmNITAEHSNHPENKHKNRYINILAYDHSRVKLrplpgkdSKHSDYINANYVDGY--NKAKA
  .. ..|....|.. .   .. ....| |||.....   ... .....||||.|||| .||.||||||||       ...||||||.|||||  .. ..
vsslklsvldllkllek..aldlglleeefeellsvkp..lleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgyssklprk

YIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTE---NSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkgnpkgRQNERV
.|||||||..|.||||||.||||. .|||.|.|||.|| ||.||||.|   .|.|||.. |||.|..... |||| . ..|..            ...|.
fIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg...........dgesrt

VIQYHYTQWPDMGVPEYALPVLTFVRRSSAARmpETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALL
| ..||| |||.|||... ..|.|...    .  . ||..||||||||||||.|..| .|.|.. . .|.|.. .|..|.||.. |||.|||.|...|||
vthfhytnWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyrall

EAILGKE
| .. |.
eylklkl
0045450 (Phosphotyrosine protein) phosphatases II 824-1122 9.8e-99 326.2 In-house 5-306 (307) alignment 
Range on Protein: 824-1122
Range on HMM: 5-306/307.0
DMEAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdSKHSDYINANYV--------DGY
 .. |......... .|  .. .|. . ||.....| ..... .....||||.|||| .||.|||.|||| .|.|. ...||||||.||        |||
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgy

NKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSE-EYGNIIVTLKSTKIHACYTVRRFSIRNTkvkkgqkgnpKGRQN
.. ...|||||||..|.||||||.|||....|||.|.|||.||.||.||||.|..| .|||. |||.|..... ||||.. . ..          .| ..
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl..........dgtge

ERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSA--ARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKST---VNVLGFLKHIRTQRNYLVQTEEQY
.| |...||| |||.|||..  ..| |...  .  .. |. ||||||||||||||||.|... ||.|...  |   |..|  .|..| ||   ||..|||
srtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqy

IFIHDALLEAILG
.|...|||| .|.
rflyeallelllk
subfamily_PTPRD_pd Subfamily PTPRD 826-1159 1e-135 448.6 In-house 3-321 (564) alignment 
Range on Protein: 826-1159
Range on HMM: 3-321/564.0
EAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCtadMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdsKHSDYINANYVDGYNKAKAYIATQ
..|||... .|. .| .|..  |.|.......     . | |..|.|.||.|||| ||.|||||||.|....|.  . ||||||...|||.| |||||||
kpipvaelkehvaklkansdlkfeeeykkieeg...qqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrkrkayIAtq

GPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkgnpkgRQNERVVIQYHYTQ
|||..|.||||||.||||. .|||.|.|.|||. ||..|||....|.||...|||....  | |..| |.....|           ... | | |.|.|.
gPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk...........ssesreVrqFhFts

WPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET
||| ||||.| ..|...|...|.. |..||..||||||||||||.||||.||..||.. ||.. ...|..|.|||..|||||||||||.|.|||.   .|
WPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgnt

EVSSNQLHSYVNSI-LIPGVGGKTRLEKQFKLVTQ
||.|..|.. .. .  .    . | ||. |. .. 
evesenlkqhlqkLaeveedtemtgleleFqrLat
subfamily_PTPRB_pd Subfamily PTPRB 826-1125 1.3e-104 344.3 In-house 5-290 (293) alignment 
Range on Protein: 826-1125
Range on HMM: 5-290/293.0
EAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAehSNHPENKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINANYVDGYNKAKAYIATQ
. | ...| .|. .. ......|||..||..    |....|  .....|. |||| |||.|||||||| .|  ||...||||||||..|||  . .||||
kpiklekfeehvkkmkadsdlrfseeyeelkavgkdqavka..aelavnraknrytnilpydhsrvkLaal..kdesgsDYinanyipgynsprefiatq

GPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTE-NSEEYGNIIVTLKSTKIHACYTVRRFSIRNtkvkkgqkgnpkgRQNERVVIQYHYT
||| .|..|||||.||... ||||.|.|||||. ||..|||.. ..  ||.| |||....    ...| ..|..             ...|| | |||.|
GPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek.............ekeerkvrqyhft

QWPDMGVPEYALPVLTFVRRSS--AARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILG
 ||| |||| . ..|.|||.    . .  ...|..||||||||||||.| .| .||.|... .|...|.. ..|..||.|||||.||||||...|. .  
sWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrk

KET
||.
kee
subfamily_PTPRA_pd Subfamily PTPRA 826-1139 1.5e-95 314.8 In-house 12-314 (330) alignment 
Range on Protein: 826-1139
Range on HMM: 12-314/330.0
EAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCtaDMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDskHSDYINANYVDGYNKAKAYIATQ
  .||... . |    ... . | |.|. .  .  ... | | ... |||.|||..||| ||.||| | .. |..  .|||||| ..|||.. . .||.|
fplpvekleeeirirsaddnklfreefnalPag..piqatlelaskeenkeknrvvnilPydfsrvilsvkeGve..esdyinasfidGykekdkfiaaq

GPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRntKVkkgqkGNPKGRQNERVVIQYHYTQ
||.. | ||||||||||..  |||.|.| |. . || ||||.| .  |||| |... ...   |||| | ..  ..     .. . ....|.| |.|.| 
GPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvq..ql.....pdatrekksrlvrqfhfts

WPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET
|||.|||  .  .| ....  . .  ..||. ||||||||||||.||.|..|...| .  |.| .|.|..|.||  .|||.||| ||. .|||  |  .|
wPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdt

EVSSNQLHSYVNSI
|.    | ......
eldvsslekhlqkl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 826-1138 6.9e-92 302.8 In-house 2-301 (305) alignment 
Range on Protein: 826-1138
Range on HMM: 2-301/305.0
EAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHsnhpENKHKNRYINILAYDHSRVKLRPLPGKDskHSDYINANYVDGYNKAKAYIATQ
. | .... ..| |  .....|. ........    .... ..    .||.|||. .|  .|..|..|.. . .|  .||||||.|||||.. |.||..|
kiialddlaayikearvysdkgleaqykslyeeeesidvgkke....ankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyivaq

GPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSE--EYGNIIVTLKSTKIHACYTVRRFSIRNTKVkkgqkgnpkgRQNERVVIQYHY
||||.| .||||.|.|  .  |||.|.||| |. || ||||.. .|  |.|...|.|||.|  . |. |...| . .            ...|.|.||. 
gPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede..........dkesrtvlqyql

TQWPDMGVPEYALPVLTFVRRSSAARMPETG-PVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILG
|.||| |||..|  .|....|   ... . | |.||||||||||||..|..| .|...|   .|.| . ||..|..| ..||| .|| |.|||| | |  
tdWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc

KETEVSSNQLHSYVNS
 .|..  . |.  || 
gdtsiigsnlrarvnk
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 826-1154 4.2e-88 290.3 In-house 4-314 (315) alignment 
Range on Protein: 826-1154
Range on HMM: 4-314/315.0
EAIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSnhpENKHKNRYINILAYDHSRVKLrPLPGKDsKHSDYINANYVDGYNKAKAYIATQ
. ||. |.. .. .  .. . || .|.| .         .| ..   |||.|||||||.|||.|||.| ||  .| .||||.|||..||||| . |||.|
qpipldqlityvaqkkastkngfkqdyesipggqlhpldvakki...enkqknryiniiaydksrvql.pllend.phsdyvnanfidGynkkrryiaaq

GPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTEnSEEYGNIIVTLKSTKIHACYTVRRFsirntkvkkgqkgNPKGRQNERVVIQYHYTQ
||. .. .||||...|.. | |||.|||||. .||...||| .    ||.| ||.|| ...  |||| .                 ..| | |.|.||| 
gpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl.............svvfgdnirevvqlhyts

WPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET
|||||||.|..|.. ..|.    .  . |...||||||||||||.| .|..|.|.. .  ..|  |.. .| .|  .||. ||| ||.|||||...  .|
wpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdt

EVSSNQLHSYVNSILIPGV-GGKTRLEKQF
 .. .      .|.| |    | | |..||
siaqdlylqrydsllapspdtgstllqeqf
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 826-926 6.6e-16 52.3 In-house 3-95 (95) alignment 
Range on Protein: 826-926
Range on HMM: 3-95/95.0
EAIPVKQFVKHIGELYSNNQHGFSEDFEEVQrCTADMNITAEHSNhpENKHKNRYINILAYDHSRVKLRplpgkDSKHSDYINANYVDGYNKAKAYIATQ
  | |  |  |. |..|| .. | ..|  ..  |.  . |.  |.   |  |||..||. || .|| |        . |||||| .|||| . ..|||.|
kpihvsvfhshvlemhsnsdqefdnefksis.mtsgapytvgsse..anipknrflnifpydatrvvlt.....tkrdsdyinacfvdgyarkncyiaaq

G
|
g
0051299 (Phosphotyrosine protein) phosphatases II 827-1120 2.2e-106 350.7 In-house 4-286 (288) alignment 
Range on Protein: 827-1120
Range on HMM: 4-286/288.0
AIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADmnITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGkdSKHSDYINANYVDGYNKAKAYIATQG
.|.|....|.. .|. |...|. | |||......|  .|  ....|||..|||| .||.||||||||..|.|  . .||||||.|.||||. ...|||||
eisveellklvlkllangltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkfIatqg

PLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKgqkgnpkGRQNERVVIQYHYTQW
||..|.||||||.||||. .|||.|.|||.||.||.||||...|..||.| |||.|..... |||| . ..|... .       | ...| |...|||.|
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlld.......gdgesrtvthfhytnw

PDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
||.|||... ..|.|.|.   |. .  |||.||||||||||||.|..| .|.|.. . .|.||...|..|.||...|||.|||.|...||||..
pdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 827-1137 4.5e-104 343.0 In-house 4-300 (319) alignment 
Range on Protein: 827-1137
Range on HMM: 4-300/319.0
AIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADmniTAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGkdSKHSDYINANYVDGYNKAKAYIATQG
 |.|... ... .| |. .... ..|....  ..|   | ......|||.|||| ||||||..||.| .|.|  .. ||||||...|||.. ...||||.
eievqeLkerlkalastgetllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldg..vegsdyinasfidgyqerekfiatqa

PLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIrNTKvkKGQKGNpkgrqneRVVIQYHYTQW
||. |.||||||.||... |.||.|.||||.. |. .|||.|| ||||..||||.. .  . | .|.... |.|  ...          | | ...||.|
PlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkk..ssevet.......RevkhfqyteW

PDMGVPEYALPVLTFVRRSSA-ARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET
|| .|||.|. .| ...|     . .. ||. ||||||||||||.||.| ||...|  ....|  . ...||||| .||..|||.||..|||||.   .|
pdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdt

EVSSNQLHSYVN
|.  ..|.  . 
eievqdlrdrlk
subfamily_PTPRK_pd Subfamily PTPRK 827-1154 5.1e-92 303.1 In-house 3-312 (314) alignment 
Range on Protein: 827-1154
Range on HMM: 3-312/314.0
AIPVKQFVKHIGELYSNNQHGFSEDFEEVQRCtadmnitAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdsKHSDYINANYVDGYNKAKAYIATQG
|| |.  ...|  |  .. .|| |..| .           . ... ||..|||. .|||||.|||.| .. |    .||||||...|.|....|.|.|||
airvadllqsiallkraegygfkeeyeslfeg.......wdaakkdenreknrsgdilaydrsrvflitidgd..pssdyinaalidsykrpaafivtqg

PLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEeYGNIIVTLKSTKIHACYTVRRFSIRNtkvkkgqkgNPKGRQNERVVIQYHYTQW
||..| .||||.....|.  |||.|.|||.|| || .||| . .  ||.| |.| .|...| . || |....           .| .. |.| |.....|
PlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrvek.........largqeeirevrqfqflgW

PDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE
|| .|| .|  .|..|||  . . .| |...|||||| |||||.|.||..|. |. ...|.|    | .|...  .|.|||||.||.|..||| |  || 
pdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgeta

VSSNQLHS-YVNSILIPGVGGKTRLEKQF
.   .... |..|| .      ..|...|
ipvsefkalylesirldpqtnssqlkeef
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 827-1139 4.9e-71 234.5 In-house 4-307 (325) alignment 
Range on Protein: 827-1139
Range on HMM: 4-307/325.0
AIPVKQFVKHIGELYSNNQHGFSEDFeevQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINANYVDGYNKAKAYIATQG
.| | ..|.|. .  ...| ||. .|   .   .|  |. . . .|||| |||. |..|.|.||| |  .  ||. .||||||.|.  . | . ..|.| 
siavvnlvehvekkkaqdqdgfahef...gllpsddgiakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqa

PLKSTFEDFWRMI--WEqntGIIVMITNLVEKGRRKCDQYWPTE--NSEEYGNIIVTLKSTKIHACYTVRRFSIRNtkVKKGqkgnpkgrqNERVVIQYH
|| .| .|.||..  |.     .|...| ...|  .| .||| |  .| ..| . | |.. .  . |  |.. ...  ||||         . | | |..
PltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkq..vkkG.........etrsvkqfq

YTQWPDMGVPEYALPVLTF---VRRSS---AARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDAL
.  |.||||...   ....   |   |    |    ..|.||||||||||||..| . |.|... ..| |...||.|..| .|  .|.| .|||.|..||
lqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyeal

LEAILGKETEVSSNQLHSYVNSI
 ||..  .|.|  . ... ..|.
veaymsgntdvpvssfeaklssl
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 827-1155 2.4e-63 208.9 In-house 3-272 (392) alignment 
Range on Protein: 827-1155
Range on HMM: 3-272/392.0
AIPVKQFVKHIGelysNNQH--GFSEDFEEVQRCTADMNitaEHSNHPENKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINANYVDGYNKAKAYIAT
 ||| ||   .     .|.|   |.|.| ..    .  .     .... |..|||| ||| || .||||  .   |. .|||.|| |.....  |||||.
pipvaqfpafve....knrhsalffeefhdlpgpdiypq...tvaqkeinlkknryknilpydsarvklevi..ddipdsdylnasyipsfdnekayias

QGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGrrkcdqywptenseeygniivtlkstkihacytvrrfsirntkvkkgqkgnpKGrQNERVVIQYHYT
|||  ....|||||....|.  |.|.|.| |                                                      || .. | | |.|.|
qgpnaaslddfwrmvfqenvttiamvtklkegd....................................................kg.ddartvaqfhft

QWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKE
.||| .||...  .| |..  .|     | |...||||||||||  | |||.. . |    |.|. |.  || .| |.|||.||| ||. |.|| .| ..
ewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrn

TEVSSNQLHSYVNSILIPGVG-GKTRLEKQFK
| .   ..  ... .   . | ....  |.|.
tlipvvhftdhlqdlstssdGdvrskqlkefr
subfamily_PTPRG_pd Subfamily PTPRG 828-1137 2.4e-158 522.9 In-house 1-304 (563) alignment 
Range on Protein: 828-1137
Range on HMM: 1-304/563.0
IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHsDYINANYVDGYNKAKAYIATQGP
.|||.|.||. .|......||||.||..|..|......||||..||||.||||.||.|||.|||||.|||||..|. |||||||.|||.|.||.||||||
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkskafiatqgp

LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKgnpkgRQNERVVIQYHYTQWP
||.||.||||||||||. ||||||||||.||||||.|||...||.||.. |||......|.||||...|.|.|.||...     ...|..|.|||||.||
lkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkq.....cdteklvrqyhytkWP

DMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEV
|.||||..||||.||..||||.. |.||..|||||||||||||||.|..|.||.....|||.|||||||.|||.||||||||||.||||||||..||||.
dhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketel

SSNQLHSYVN
...|...  |
laeqveelkn
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 828-1138 2.7e-116 383.1 In-house 2-298 (318) alignment 
Range on Protein: 828-1138
Range on HMM: 2-298/318.0
IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTAdmNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdsKHSDYINANYVDGYNKAKAYIATQGP
|.|... .|. .| .. .  .||..|...|...  ..|. .|..| ||.||||.|||||||.||||..| |.  . ||||||||.|||.. |||||.|.|
isvedleshvrrlresGelllseeyerlsrsee..tvtslkslepvnkaknryanilaydhtrvkLqmlege..egsDyinanyidGyrrkkayiaaqaP

LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKkgqkgnpkgrqNERVVIQYHYTQWP
|  |.||||||.||||. .|||.|...|.|..|...||| ..|..||.. |.||...  . |..|.|....|...           ..|.| |||||.||
lpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteee...........esrqvrqyhytsWp

DMGVPEYALPVLTFVRRSSAAR-MPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE
| |||| .  .| .||..|.|   ...||..|||||||||||..|..|..|..||. ..|.|... |..|.||| .||||.||.||.|.||||.   .||
degvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdte

VSSNQLHSYVNS
|....|.| .. 
vdasdlrsrire
0043336 (Phosphotyrosine protein) phosphatases II 828-1118 3.1e-95 314.0 In-house 2-275 (278) alignment 
Range on Protein: 828-1118
Range on HMM: 2-275/278.0
IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTAdmnITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSkhSDYINANYVDGYNKAKAYIATQGP
|.||...|.. ||. |........|||.....    .| .....||||.|||| .||.|||||||| .|.|  .  ||||||.||||||. ...||||||
isvkdllkallelllnlktllllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfiatqgP

LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPtENSEEYGNIIVTLKSTKIHACYTVRRFSIRNtkvkkgqkgnpKGRQNERVVIQYHYTQWP
|..|.||||||.||... .|||.|.|||.|| ||.|||| ..|..||.. |||.... .. |||| . . |           .|  ..| | .|||. ||
lpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn...........lgdgesrtvthyhylgwp

DMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
|.||||   ..| |...   |. .. ||||||||||||||||.|... .|.|...  .|...  .|..|.||   |||..||.|...||||
dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_Ptp69D_pd Subfamily Ptp69D 828-1138 8.9e-92 302.5 In-house 4-304 (307) alignment 
Range on Protein: 828-1138
Range on HMM: 4-304/307.0
IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCtaDMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDskHSDYINANYVDGYNKAKAYIATQGP
|....  . .     . ..|. ...|....    .. ... |.. ||. |||| .| |.|. ||||....||.  .||||||... ||.. | .|| |.|
iaiddleealksrkrdtdfglakeyekLear..eidkstkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgykekkkfiaaqdP

LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKgnpkgrQNERVVIQYHYTQWP
. .| .||||||.||.  .|||..|| || |.||..||| |.  .||.|.|.| |.. |  |. | ... ..| . |.       ...| |.|||||.|.
veatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgev......edsrkvvqyhytgWk

DMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEV
|. ||| |  .| ....       . .|..|||||||||.|... .||.|||.|   .|..  . |..| ||| |||  |||.|.. |||. .   .|..
DskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtde

SSNQLHSYVNS
. ..|.. ...
dvddledaier
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 828-1120 9.9e-79 259.2 In-house 2-283 (290) alignment 
Range on Protein: 828-1120
Range on HMM: 2-283/290.0
IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMniTAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGP
|||..| ... .  .....|| ..|. ..    .   |... . ..||..||. ||. ||  |. |||..|.     .|||| |..||...|.|||||||
ipvdkfgefvanghakgnegfrnqfkmldsgeseh..tvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgp

LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkgnpKGrQNERVVIQYHYTQWP
...|  |||..||.... ||||.|| .|.|. || ||||......||.. ..| . ...  |. |.....|..         .. .... |.||. | |.
vsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknkn.........sa.gakqsvtqyqitnwd

DMG-VPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
. | |....  .|.. ..    | .  ....||||..|||........  ... | .  ..|.  ||. |.|.  .|||..|| .|.. .|...
stgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 828-1149 1.1e-74 246.1 In-house 3-307 (315) alignment 
Range on Protein: 828-1149
Range on HMM: 3-307/315.0
IPVKQFVKHIGElySNNQHGFSEDFEEVQRCTADMNitaEHSNHPENKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINANYVDGYNKAKAYIATQGP
||| ||   . .    .   |||.| ..    .  .     . ...| .|||| ||| .|..||||  .   || .|||||| |. .... |||||.|||
ipvaqfpafvnk..nrhtalfseefhdlpdPdiyrq...rvaretinfkknryknilPldsarvklevi..ddsPdsdyinasyiksvdddkayiasqgP

LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPT--ENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkgnpkgrqNERVVIQYHYTQ
||.. .|||||......  |||.|.. |  . || ||||    .| |.|.| |.| |..  .  ..|.. .|...             . | | |...|.
lkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkse.............esrtvtqfqfte

WPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET
||| ||.. .  .| ...   | . ... ..||||||||||||  | ||....|||....|.|. |.| .|..| |||||||.| ||.||.|| .| ..|
wPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrnt

EVSSNQLHSYVNSILIPGVG-GKTR
 .   ..  ... .   . | |...
lilvihftdhlqdlhtsvdgsgrsk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 828-1127 4.8e-74 243.9 In-house 2-285 (287) alignment 
Range on Protein: 828-1127
Range on HMM: 2-285/287.0
IPVKQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNItAEHSNHPENKHKNRYINILAYDHSRVKLRplpgkdSKHSDYINANYVDGYNKAKAYIATQGP
|||..| . . .   ... ||.. |  ... | . .    |.  ..||.|||. .|| .|  || |.       .| ||||| ..|||...||.|....|
ipvekfgefvakghakgnegfknqftvleqvtqrede.vthniasqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekkafiiaesP

LKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqKGnpkgrQNERVVIQYHYTQWP
. .|  .||..|...|  .|||.... |. ...| ||||.|.|  .|.  ..| . ...| |..|.. ..|..     |      .... | ||..|.|.
mfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknkn.....ka.....gdkqqvkqyqitnWd

DMG-VPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE
. | |.|..  .| . ..  . | .  ....||||..|||..... ..  ... |   ...|.  ||. | |.   ||| |||.|| |..|| .   || 
stgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety

V
.
s
0040438 (Phosphotyrosine protein) phosphatases II 830-1144 2.6e-102 337.6 In-house 2-300 (317) alignment 
Range on Protein: 830-1144
Range on HMM: 2-300/317.0
VKQFVKHIGELYSNNQHGFSEDFEEVQRCTADmniTAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGkdSKHSDYINANYVDGYNKAKAYIATQGPLK
|.......  |. .. ....| ||...... |   | .....||||.|||| .|| |||||||| ||.|    .||||||.||||.|. ...|||||||.
vldlllalldllksdftalleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlp

STFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTkvkkgqkgnpkGRQNERVVIQYHYTQWPDM
.|.||||||.|||....|||.|.|.|.||.||.||||.... .||...|||.|.. .| .|.|.. . ..           | ...| | ..||| |||.
ntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl...........gdsesrtvthfhytgWpdh

GVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSS
|||..  ..| |...  .|. .. ||||||||||||||||.|... ||.|.. . .|.|   .|..| ||.. |||.|||.|..||||| .. |.| .. 
gvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepa

NQLHSYVNSILIPGV
..|....  .||| .
selklkllkllipla
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 831-1132 2.9e-74 245.1 In-house 5-291 (439) alignment 
Range on Protein: 831-1132
Range on HMM: 5-291/439.0
KQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdsKHSDYINANYVDGYNKAKAYIATQGPLKS
..| .|. .|  |.|  |.| ||...    | .  |    .  .. |||| .. |.||.|| |. .||    || ||||||..|| . | ||||||| | 
defqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgv..phshyinanyikGyyddklyiatqgpkke

TFEDFWRMIWEQNTGIIVMITNLVEKGRrkcdqYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKkGqkgnpkgrQNERVVIQYHYTQWPDMG
| .||||...|..|  |||.|||||  .     |||...   ||.|.|          |..| | . | . . .        ..|| |.|.||. |||  
ttddfwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdt.t........ekertvlqfhyiawpdkn

VPEYALPVLTFVRR-SSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSS
||  |  || |.|   ||    |.|||.|||||||||||| | .|  |.|.| .  |.. | .| .| ||. .||.  ||.||..|.|| |   .. |. 
vpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavti

NQL
...
def
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 831-1124 9.4e-51 167.4 In-house 7-291 (305) alignment 
Range on Protein: 831-1124
Range on HMM: 7-291/305.0
KQFVKHIGELYSNNQHGFSEDFEEVQRCTaDMNITAEHsNHPENKHKNRYINILAYDHSRVKLRPlpgkdSKHSDYINANYVDGYNKAKAYIATQGPLKS
|| .| . .   .  .|. ..|  ..|   |..       . ....|||| ..   |. ||||..     .   .|| ||||    ..| .| || ||. 
kqilkfvkrtlekgpaglraefvamkrfn.dfekmkaf.keaqeagknrykdvgcldnnrvkleg.....pwpheyihanyvstptnpkrfictqaplek

TFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLK-STKIHACYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPDM
|  ||| | ....   | |. ||.||| .|| .|..... ..        | | |. .. |..  .  ..||.. .       .. | | .||. .||| 
tcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdr

GVPEYALPVLTFVRRSsaaRmPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVN-VLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKE
|||   | .| .. ..   | |  ||. ||||||.||||. .... .|.|.     ..     |..|| |||  .||..||.|.|. .|. .. |.
gvpaadlailelleka...r.pskgpivvhcsagigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkkk
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 831-1118 4.1e-47 155.2 In-house 12-281 (290) alignment 
Range on Protein: 831-1118
Range on HMM: 12-281/290.0
KQFVKHIGELYSNNQHGFSEDFEEVQRCTADMNiTAEHSNHPENK--HKNRYINILAYDHSRVKLrplpgKDSKHSDYINANYVDGYNKakAYIATQGPL
. | |   .  . | .... .. |  .     .   | .   .|   .|||| ..   | .|| |     ||  . ||. ||||.| .    .| |||.|
eafekfasdvvkknvdelakeyleklkpylpvq.ylerkifdkntefkknrykdvvcndktrvil.....kdGydGdyvhanyvkGlka..mfiltqGal

KSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSE--EYGNIIVTLK-STKIHACYTVRRFSIRNTKvkKGQkgnpkgrqnERVVIQYHYTQ
|.|  |.|||. ....  |||. .|.|.|. ||.||.| .. |   .|.| |.   ...  |    . .|.|. .  .|.         | ..  ..   
kdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkd..sGk.........ehklkhlkiks

WPDMGVPEYALPVLTFVRrsSAARMpeTGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
|||  |.  .| .|  .|  .  ..  .||| ||||||.|||||.. |.  || . |   ...|.  . .|  |   || . ||. . ..||.
wpdksvalstlallrtlr..ilrka..sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_PTPN9_pd Subfamily PTPN9 832-1121 1.4e-81 268.8 In-house 5-291 (297) alignment 
Range on Protein: 832-1121
Range on HMM: 5-291/297.0
QFVKHIGElysNNQHGFSEDFEEVQRCTadMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdsKHSDYINANYVDGYNKAKAYIATQGPLKST
..|... |   ....| |....|... .  .. |...|... | .|||| ..| ||..||.|  ....  ..|||||||.||||.. ||.|||||||| |
elvayvke...kgkrGlskeyaeirnep..veGtflasklranleknrytdvlcydetrvvlakvded..easdyinanfvdGykqkkafiatqGplkkt

FEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWP--TENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkgnpkgRQNERVVIQYHYTQWPDM
..|||||.|||.. .|||.| .||.||.|| ||||  .|.|.|.|.. |.  ... .  |.|| . |.|.|            ...| |. . .. ||| 
vsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvk...........teesrkvthfqflsWPdy

GVPEYALPVLTF---VRRSSAA----------RMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDAL
|||. |  .| .   ||.  |.            |.  |..||||||.|||||.| .|  |.......||.|   .|..|||| . .||.||| | . |.
GvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylav

LEAIL
||  |
leyal
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 834-1120 7.4e-91 299.2 In-house 9-279 (288) alignment 
Range on Protein: 834-1120
Range on HMM: 9-279/288.0
VKHIGELYSNNQHGFSEDFEEVqrCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPgkDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFE
|... .   .|. ||||... .   . . . . . .....|..|||| |||.||. ||||. |.  . . .|||||.|.||..| |.|||||||| .| .
vakvakksarnrtgfseeynsL..aalektksvtagrlavnakknRyrnilpyDekrvklkkle..eeagaDYinasyidgekkkkkyiatqgPladtvn

DFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENS-EEYGNIIVTLKSTKIHACYTVRRFSIRntkvkkgqkgnpkGRQNERVVIQYHYTQWPDMGVP
|||....|..|  |||.|.|||.|..||..|||...  ..||.. |||...|    ...|.. .               ...|. . ||.|. |||.|||
dfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.............kkkteleitqyqylaWpdhgvP

EYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
| . |.| ..|    |   .|||..||||||||||||.|..| ...... . ...|.|.....| ||. ||||..||.||...||. |
eskapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli
subfamily_PTPN23_pd Subfamily PTPN23 834-1119 5e-57 187.9 In-house 3-279 (288) alignment 
Range on Protein: 834-1119
Range on HMM: 3-279/288.0
VKHIGELYSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRplpgkdSKHSDYINANYVDGYN-KAKAYIATQGPLKSTF
|... . . ... .. . |.|...  .  .     .    . .|||. .|| |||.|||||      ... ||||| .| .    .  .||||.||.|| 
veelqrkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstl

EDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTEN--SEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVkkgqkgnpkgrQNERVVIQYHYTQWPDMG
 |||.|..|| . .|||...  |.|. |.|.|||...  ....|.. |||||..    .  | ....  ..           .. . |   ..|.||..|
nDFWlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletlda...........davksvshlqltsWpelG

VPEYALPVLTF---VRR-SSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKS-TVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEA
||.    .| |   |.   .| . .   |..|||||||||||.. .. . ..... .   ....  ....|.|| . ||..||. |  .| |||
vPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 835-1120 1.5e-86 285.0 In-house 4-276 (281) alignment 
Range on Protein: 835-1120
Range on HMM: 4-276/281.0
KHIGELYSNNQHGFSEDFEEVQRctADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPlpGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFED
||. .| .|...|| |..|...   .... ||. |...||..||||.|| |||..|||. |   ...|..||||||.|.||.. |.|||||||. .....
khlkqlsqndnaGfieeyeklaa..igvdntataskadenvlknrYsnivaYDatrvkvtp..neenkntDYinanfvpgykgekeyiatqgPvPaslva

FWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTEN-SEEYGNIIVTLKSTKIHACYTVRRFSIrNTKvkKGqkgnpkgrqNERVVIQYHYTQWPDMGVPE
||.|.|||.  .|||.|. .|.|. || .||| .| . .||...|. .... .| |  |.|.. ...  .|         ..| | | .||.||| |||.
fWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.ere..sg.........etreveqlaytaWPdhGvPa

YALPVLTFVRRSSAARMPET-GPVLVHCSAGVGRTGTYIVIDSMLQQIKDK-STVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
 .  .| | .    .. ..|  |...||||||||||||| .| ........ ....|   ....| .||..|||  || |.. |.|.|.
ttkellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldal
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 840-1119 9.4e-63 206.7 In-house 12-292 (301) alignment 
Range on Protein: 840-1119
Range on HMM: 12-292/301.0
LYSNNqhgFSEDFEEVQRCTADMNiTAEHSNhpENKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMI
 .||.   |.|...|... . . . | ..|.  |||. ||. ||  ||. |. |.| |  |... .||||.|.|||...|..||.|||.|.|  ||||.|
khsnk...feeqykelkegedksc.tvglse..enkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrli

WEQNTGIIVMITNLVEKGRRKCDQYWPT--ENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKK----GQKGNPKGRQNERVVIQYHYTQWPDMGV-P
|.. .  |||.||| |. . || ||||.  ..|||.|.. |||......  ...|..... ... .     .| . | ... . |.|.. |.||. || .
wqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvr

EYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEA
|..  .        . . .. |||.||||..|.|.|.|. ..  | | |    |.| .  | .| ..   |.| |||..|.|.. . 
eprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_PTPN6_pd Subfamily PTPN6 841-1119 8.7e-86 282.7 In-house 21-296 (306) alignment 
Range on Protein: 841-1119
Range on HMM: 21-296/306.0
YSNNQHGFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRplpGKDSKHSDYINANYVDG--YNKAKAYIATQGPLKSTFEDFWRM
 | .. ||.|.|||.|.  |   .. .....||||.|||| ||| .||.||.|.    .. . ||||||||...   .. |.|||||| |..| .|||||
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrm

IWEQNTGIIVMITNLVEKGRRKCDQYWPTEN-SEEYGNIIVTLKSTKIHACYTVRRFSIRNTkvkkgqkgnpKGRQNERVVIQYHYTQWPDMGVPEYALP
.|..|. .|||.|. ||.|. || .|||.|. .||||.| ||  | | .| |..|..|. ..          |  ..|| |.|||...||| |||.    
vwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk..........kkkkeerevfqyhfksWPdhgvpkdpga

VLTFVR---RSS-AARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKS---TVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEA
|| |..   | .   .  |.||..||||||.|||||.|||| .|..|. |     ...  . | .|.||. |||||.|| |.. |. . 
vLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
subfamily_PTPRN_pd Subfamily PTPRN 841-1118 2.1e-60 198.9 In-house 24-290 (297) alignment 
Range on Protein: 841-1118
Range on HMM: 24-290/297.0
YSNNQHGFSEDFEEVQRCTADMNiTAEHSNHPENKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINANYV-DGYNKAKAYIATQGPLKSTFEDFWRMI
. .|.. .....| . .  |. . |.| .....| .|||. ..|.||||||||.     ....||||||  . |   .| ||||||||| ||  |||.|.
hlknkdrlekewealcayeaeps.tkevakaeknvkknrskavlpydhsrvklkee..asaeksdyinasaildhdprapayiatqgplastvadfwqmv

WEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHA-CYTVRRFSIRNTKvkkgqkgnpkgRQNERVVIQYHYTQWPDMGVPEYALPV
||| . .||..|.| |.| ..|..||| | || |.   | | | .| .  | || | ..| .            .. | | |.|.  ||..|||  | ..
weqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlq...........tsetrtvtqfhflswpeegvPasaksl

LTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQI-KDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
| | |.   .    . |..||||.|.||||.||.|| .|... |    ...   |.|.| ||. ||.|..|. |.  |. |
lefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 842-1127 7.8e-92 302.7 In-house 23-297 (298) alignment 
Range on Protein: 842-1127
Range on HMM: 23-297/298.0
SNNQHGFSEDFEEVQRCTADMN-ITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPgkDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIW
...  |....|..... . ...  . | ...||||.|||| .|.|.|.||| |.     . ..|||||| ....|.. .|.||||.||..|.||||||..
kkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvt

EQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkgnpkgRQNERVVIQYHYTQWPDMGVPEYALPVLT
|.. | |||.|||.|... |. .|||.|..|.||.| |.|.|.. .| ..||.. . ..|           ...|| | | |.|.||| ||||.|  ||.
eedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkk...........eekerevrqlhftsWpdkgvpenatsvld

FVRRSSAaRMPETG--PVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEV
..|.  |    ..|  ||.|.|||||||.||.|.|||.|...| ...| |.  .| .|..|  .|||||||.||..| |||.   ..|.
llrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 842-1157 3e-74 245.0 In-house 12-314 (515) alignment 
Range on Protein: 842-1157
Range on HMM: 12-314/515.0
SNNQHG--FSEDFEEVQRCTADMNI-TAEHSnhpeNKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRM
. |.|   |||.| ..       .  . |      | .|||| ||| || .||||  .  .|. ||||.|| |. ...  |||||.|||.|.. .||||.
nknrhttlfseefhdlpgpniypqtvaqeei....nfkknryknilPydsvrvklevi..ndnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrl

IWEQNTGIIVMITNLVEKGRRKCDQYWPT--ENSEEYGNIIVTLKSTKIHACYTvrrfsIRNTKVKKGQkgnpkgrqNERVVIQYHYTQWPDMGVPEYAL
....|.  |.|.|.| |  . || .|||    .| ..|.| | | |..  .  .     .|. .| ||.        . | | |.|.|.||| |||. . 
vlqenvttiamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggi.....krkltvlkgd........dsrtvtqfhfteWPdkGvpkhts

PVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYV
 .| ...   | .   | |...|||||||||| .| |||.. ..|.  .|.|. |.. || .| |||||.||| ||..|.|| .| ..| .   ..  ..
sllklikevkadhgqythpliihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhl

NSILIPGVG-GKTRLEKQFKLV
. .   | | |.... |.|. .
qdlhssgdgrgrskmtkefqtl
0036941 (Phosphotyrosine protein) phosphatases II 843-1133 4.5e-99 326.8 In-house 10-290 (297) alignment 
Range on Protein: 843-1133
Range on HMM: 10-290/297.0
NNQHGFSEDFEEVQRCTAdmNITAEHSNHPENKHKNRYINILAYDHSRVKLrplpgkDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQ
.. ..... |||.... .  ... .... |||..|||| .||.|||.||||      |. .||||||.|||||.  ...|||||||..|.||||||.|||
lflalllkefeellplll..lgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweq

NTGIIVMITNLVEKGRRKCDQYWPTE--NSEEYGNIIVTLKSTKI--HACYTVRRFSIRNTkvkkgqkgnpkGRQNERVVIQYHYTQWPDMGVPEYALPV
|. .|||.|.|||.|| ||.||||.|  .| .||...|||.|...  .. ||.| . . .|           | ...|.| ..||| |||.||||.. ..
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt...........gngesrtvthfhytgwpdhgvpespasl

LTFVRRSSA--ARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIK---DKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLH
| |...     . .|. |||||||||||||.||.|..| ||||..      .|..| ..|..|.||.  |||.|||.|...|||| .. |.| .. ..|.
ldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklv
0047943 (Phosphotyrosine protein) phosphatases II 843-1120 1.7e-97 321.4 In-house 9-272 (273) alignment 
Range on Protein: 843-1120
Range on HMM: 9-272/273.0
NNQHGFSEDFEEVQRCTAdmNITAEHSNHPENKHKNRYINILAYDHSRVKLrplpgkDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQ
.. ... | ||......   ..| .....||||.|||| .||.||||||||      ....||||||.||||||. ...|||||||..|.||||||.|||
lgltllleefelllslkp..lltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

NTGIIVMITNLVEKGRRKCDQYWPTEN---SEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkgnpkgRQNERVVIQYHYTQWPDMGVPEYALPVL
|. .|||.|.|||.||.||.||||.|.   |..||...|||.|......|||| . ..|..            ...|.|...||| |||.|||..  ..|
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg...........tgesrtvthfhytgwpdhgvppslesll

TFVRRSSAARMP--ETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
.|..    |.    . |||.||||||||||||.|..| .|.|.. . .|.||  .|..|.|| . |||.|||.|...|||| .
efielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 843-1137 9.9e-85 279.6 In-house 31-308 (319) alignment 
Range on Protein: 843-1137
Range on HMM: 31-308/319.0
NNQHGFSEDFEEVQRCTADmNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDskHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQ
...  .  .|  . . ...   . ...| ..|| |||.|||||.|...|||..| |..   |||||| .|.|| . . |||.||||. | .||||||||.
ddltklevefrracklgvn.ladqtfanldqnkdknriinilafdknvvklerliGee..fsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiwey

NTGIIVMITnlvekgRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQkgnpkgrqneRVVIQYHYTQWPDMGVPEYALPVLTFV
|.  ||..|      . || |||| .  .....  | ..| .  | |.|| . . .   .|..          | . |.|.  |||.|||.|. .....|
ncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdi..........rkitqfhflGwpdvGvpdypsdlmrlv

RR--SSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVN
..      .. .  ...|||||||||||.|||.| .|...|... |.|  |.. .| ||| |||   || ||. ||||  |   ..|.  .. .|..
kkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayle
subfamily_PTPN12_pd Subfamily PTPN12 843-1120 3.5e-77 254.2 In-house 5-277 (290) alignment 
Range on Protein: 843-1120
Range on HMM: 5-277/290.0
NNQHGFSEDFEEVQRCTAD----MNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDskHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRM
.... |...|........       ...|.....||..|||| .|| ||.|||.|.   ...  .|||||||.. | .. ..|||.||||  | .|||||
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeee..gsdYinanfikgvegkleyiaaqgPLpktlddfWrm

IWEQNTGIIVMITNLVEKGRRKCDQYWPTEN--SEEYGNIIVTLKSTKIHAcytvRRFSIRNTKVKKGqkgnpkgrQNERVVIQYHYTQWPDMGVPEYAL
|||.|. |.||. ..|| |. ||..||| |.  . |.|.. |||.. |         | ||  ||..         ...|.| |.|||.||| |||. | 
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavd....ddflirtLkveaq........kesrkvyqfhYtaWPDhgvPssak

PVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKST---VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
..| ...     .  |  |..|||||||||||| |.|| . ...|.. .   ..|   . ..|.||. ||||.||| ... |..| .
sllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 843-1134 1.8e-61 202.6 In-house 6-280 (283) alignment 
Range on Protein: 843-1134
Range on HMM: 6-280/283.0
NNQHGFSEDFEEVQRCTADMNITAehsnHPENKHKNRYINILAYDHSRVKLRPLPGkdskhsDYINANYVD---GYNKAKAYIATQGPLKSTFEDFWRMI
||.. | | ....     | .|..      |||.|||. .|...|  ||.|....       ||||| ..     |.. | ||..|.||. |  |||.|.
nnnklfrevlkrlsvpdldadias....adenkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmv

WEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTkvkkgqkgnpKGRQNERVVIQYHYTQWPDMGVPEYALPVL
....   |||.|.| |  | || |||| . ||.||.  |||.    .  .... . .|.              ... ..  | . .| ..|       ..
fdekitaivmltklqedlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn..........ssakstlllahyqvidWleygeqaiinslv

TFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHS
 | .  |  .  . ||..||||.|.|||...| . . ..... .| |.|   .| .| ||  .||| .|| ..|.. ||  |  .|..   .|.|
kfnkvislqteskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqs
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 845-1118 3.2e-47 155.8 In-house 5-257 (267) alignment 
Range on Protein: 845-1118
Range on HMM: 5-257/267.0
QHGFSEDFEEVQRCTADMNITAeHSNHPENKHKNRYINILAYDHSRVKLRplpgkdSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNT
.  . ..||.... . . .  .  |   .|. .||. . | ||..|| ||       |  .|||| ||.||.. .|.|.||.||| |  ||. .| .|. 
eceiekefelikkisdtsstis.qsiaeknqernrlddnlpyddtrvilr......tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkv

GIIVMITNLvekGRRKCDQYWPTE--NSEEYGNIIVTLKSTKIHACYTVRRFSIrntKVKKGQKGNpkgrqnervVIQYHYTQWPD-MGVPEYALPVLTF
 .||..|.    .  .  ..|| .  ....| .. |     |    | .  . .   |.|.    |         |  |.| .|        |  |..  
pvivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlel...kfknesahn.........vtlyyykkwnintnnkpylkplfgi

VRRSSAArmPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
. .          |..|.||.||||.||..||||.|...|  .....  ||..|| ||  ||.| |.||.||. | |
laknqle..ngnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 845-1126 4.9e-22 72.7 In-house 25-291 (302) alignment 
Range on Protein: 845-1126
Range on HMM: 25-291/302.0
QHGFSEDFEEVQRCTADMNItaeHSNHPENKHKNRYINILAYDHSRVKLRplpgkdSKHSDYINANYVDGYNKAKAYIATQGPLKSTF---EDFWRMIWE
.    ..|....   .|..     . . .| .||.  .. ..|. .|||        .  .|.||  |.  .  .  | .| | ...    |.||||...
taevkkefkkidtmkvdlek...Ckafkknlkknqsedvpildsnlvkle......aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfq

QNTGIIVMITNLVEKGRrKCDQYWP--TENSEEYGNIIVTLKSTKIHACYTvRRFSIRNTkvkkgqkgnPKGRQNERVVIQYHYTQWPDMGVPEYALPVL
..   .|..    |  .   ....|  ... .|||.. |  .  .     .  |..|            |.|  |  ..  |. |.|..  ||.    . 
ekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvl.........PegcsnsvlanvyvltnWkqkkvpvkyaeli

TFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE
. .    |  .. . ....    |.|| |. ..    ........ .|.   .| ||.||   |.. .||.... |||  |. | |.
ktaakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkvtk
0046845 (Phosphotyrosine protein) phosphatases II 847-1125 1.7e-100 331.3 In-house 1-279 (284) alignment 
Range on Protein: 847-1125
Range on HMM: 1-279/284.0
GFSEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdSKHSDYINANYVDGY-----NKAKAYIATQGPLKSTFEDFWRMIWE
|. |.|||....| .. .. .....|||..|||| .||.||||||||..|.|. ...||||||.|||||     .. |..|||||||..|.||||||.||
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgd.ledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvwe

QNTGIIVMITNLVEKGRRKCDQYWPTEN-SEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVkkgqkgnpkgRQNERVVIQYHYTQWPDMGVPEYALPVLT
||. .|||.|.|||.|| ||.||||.|. . .||...|||.|.... .||||.....|...           ...| |...|||.|||.|||... ..|.
qnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy..........tgesrtvthfhytswpdhgvppspedlle

FVRRSSAARM--PETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKS---TVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET
|.|    ..   |  ||..||||||||||||.|..| .|.|.. ..   .|.||. .|..|.||.. |||.|||.|...||||... | |
flrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt
subfamily_PTPN1_pd Subfamily PTPN1 847-1121 4.1e-67 220.9 In-house 7-272 (290) alignment 
Range on Protein: 847-1121
Range on HMM: 7-272/290.0
GFSEDFEEVQRCTAdmNITAEHSNHPENKHKNRYINILAYDHSRVKLRplpgkdSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGI
 ..| ...... .   .........|||. .||| ..  |||||.||.      ... |||||. |.  .  . || ||||| .| . ||.|.|||..  
lykeiyldirkeas..dfptreaklpenrnlnryrdvspydhsrikle......radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkska

IVMITNLVEKGRRKCDQYWPTENSE-----EYGNIIVTLKSTKIHACYTVRRFSIRNtkvkkgqkgnpKGRQNERVVIQYHYTQWPDMGVPEYALPVLTF
.||. ..|||.. || ||||....|     |  .. |.| |....  |||| . . |           .  |. |.....|||.|||.||||     | |
vvmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen...........lktqetreilhfhyttwpdfgvpespaaflkf

VR--RSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKS---TVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAIL
.   |.| .  .. ||...|||||.||.||....|..| .|..|    .|..   | ..| .|  |.|| .|  | . |.|| . 
lfkvresGslssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
DSPc_SM00195 848-1120 2.5e-93 307.6 In-house 2-262 (263) alignment 
Range on Protein: 848-1120
Range on HMM: 2-262/263.0
FSEDFEEVQRCTADMniTAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdsKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGII
..|.||.... | .   . .......||.|||| ||| |||.|||| . ..|  ..||||||||..|.|| |.||||||||.||.||||||.||... ||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkii

VMITNLVEKGRRKCDQYWPTE--NSEEYGNIIVTLKSTKIHA-CYTVRRFSIRNTKVkkgqkgnpkgrQNERVVIQYHYTQWPDMGVPEYALPVLTFVRR
||.|. .|.|..|||.||| |  ..|..|.| |.|......   ...| .......            ...| | ||.|..||| |||. . .|| ..| 
vmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...........eetrkvtqyqyknWpdhgvpdstksvlellra

SSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
    .  ..||..||||||||||||...||..|........|..   .|..|.||  .|||.|||.||..|.||.|
vkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 848-1120 2.5e-93 307.6 In-house 2-262 (263) alignment 
Range on Protein: 848-1120
Range on HMM: 2-262/263.0
FSEDFEEVQRCTADMniTAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdsKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGII
..|.||.... | .   . .......||.|||| ||| |||.|||| . ..|  ..||||||||..|.|| |.||||||||.||.||||||.||... ||
lkeefekleestspk..etteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkii

VMITNLVEKGRRKCDQYWPTE--NSEEYGNIIVTLKSTKIHA-CYTVRRFSIRNTKVkkgqkgnpkgrQNERVVIQYHYTQWPDMGVPEYALPVLTFVRR
||.|. .|.|..|||.||| |  ..|..|.| |.|......   ...| .......            ...| | ||.|..||| |||. . .|| ..| 
vmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk...........eetrkvtqyqyknWpdhgvpdstksvlellra

SSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
    .  ..||..||||||||||||...||..|........|..   .|..|.||  .|||.|||.||..|.||.|
vkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN13_pd Subfamily PTPN13 848-1120 9.7e-64 210.3 In-house 13-269 (273) alignment 
Range on Protein: 848-1120
Range on HMM: 13-269/273.0
FSEDFEEVQRCTADMNitAEHSNHPENKHKNRYINILAYDHSRVKLrplpgK-DSKhsdYINANYVDGY--NKAKAYIATQGPLKSTFEDFWRMIWEQNT
 .|.|.|..   .  .  .| ... |||.|||| |.| ||..||||     . ..    ||||...     ..   |||.||||  | .|||.|.|||..
Paeefkelrelkpldt..cevgkkkenkdknryrnvlPydetrvkl.....gdegg...yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqka

GIIVMITNLVEKGRRKCDQYWPTENSEEYgNIIVTLKsTKIHACYTVRRFSIRNTKVKKGQKGNpkgrqnERVVIQYHYTQWPDMGVPEYALPVLTFVRR
 .|.|.|. .|||. ||..||| .....   .   |.  .         |..|. .||. . |.       | | . ....||| |||  |...|.||..
eviamvtlekekgkvkchrywPesknkkl.kvsnrle.vellkvqkldgfvvralavkdsesge......srevahlnfvkwPdhgvPssaaellqfvae

SSAARMpETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
    .  ..||..||||||.||.||.|.|| .|. |. .  ..|   ....| ||. .|||..||||.. |.||..
vrrlqt.dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 848-1127 5.1e-50 165.2 In-house 18-284 (307) alignment 
Range on Protein: 848-1127
Range on HMM: 18-284/307.0
FSEDFEEVQRCTAD-MNITAEHSnhpeNKHKNRYINILAYDHSRVKLRplpgKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGI
. ..|... . | . ... | ..    | .|||| .. . |..|. ..     |   |||| |||.    | | .|..||||..|  .|| |. ...   
lvdefrvlakktpegvtveafsa....ntdknryqdvkcqdkgrivvk....fdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekves

IVMITNLVEKGRRKCDQYWPTENSEEygNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKgNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVrrsS
..|. ...| .. ||.|||| |. ..  .. .    |   |   .....  .  ..  .  . .  |. | . .. ...||| |||.  |  . ..   .
vimlckvielakikceqywpleegqk..lvfgeapntisvanlgakklapdedlinvttl.kvdwaqksrtiqhlqwenwpdrgvpqinltainll...e

AARMpETGPVLVHCSAGVGRTGTYIVIDSMLQQ-IKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEV
| |  .| ||.|||||||||.|| . |  . .. |. .   ..  ... .|.||.| .||| ||...|  |||  | .  | 
avry.dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyket
subfamily_CG7180_pd Subfamily CG7180 849-1123 1.3e-64 212.7 In-house 16-293 (296) alignment 
Range on Protein: 849-1123
Range on HMM: 16-293/296.0
SEDFEEVQRCTADMNI-TAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKHsdYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGII
   .. . . |. ..| .  .  . ||. |||..... ||. || |. | |.....  |||| |||.. | |.|| |..| |.| ..|||.......  .
rveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksd..YinavyvdsflkkkeyivteapkketvdefWrlvydeeisav

VMITNLVEKGRrKCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKgRQNERVVIQYHYTQWPD-MGVPEYALPVLTFVRRS-
|..|.  .  . .. .||| .  |.||.|.| . ..|  |  . | | .  . |  ... ..    ..|.| ....|.|.    ||  .  .. ..||  
vvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqv.kaetRivklfqlteWeledkvPlstnalielrrrvr

-SAARM---PETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGK
    ..   ||.|||.|..| |..|.| |. ||  |.... .  |.| ...| .| .|. ||.. |.| .| | ||||.| .
lwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcn
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 849-1117 5.2e-53 174.7 In-house 13-274 (287) alignment 
Range on Protein: 849-1117
Range on HMM: 13-274/287.0
SEDFEEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPgkdSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIV
 .... ... .  . .|   ...  . .|||| ..| .|..|| |   .    . ||||||||| .|.. .|.||.|||. .|  ||||...|...  ..
dkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaeg...elGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvi

MITNLVEKGRRKCDQYWPTENSEE--YGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkGnpkgrQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRS-
..|  ||..| || .|||  .      |  .| |. .. .  |.|| . . . .      .     .. ||| |... .||| ...  |. .. ||    
tmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidle......t.....rearvvkqldllswPdkvlaPtavglirfvldvk

---SAAR-MPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALL
    .||   |.||..||...|.||.|... .  .... .|   |.|   . ..| .|. |||.  |. .. .|| 
qhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 849-1126 3.9e-43 142.2 In-house 27-295 (305) alignment 
Range on Protein: 849-1126
Range on HMM: 27-295/305.0
SEDFEEVQRCT-ADMNITAEHSNHPE--NKHKNRYINILAYDHSRVKLRplpgKDSkHSDYINANYVDGY-NKAKAYIATQGPLKSTFEDFWRMIWEQNT
 |.| .. . |  ||  .|  .|.    .. |||| .. . |.| |||     | |  |||| ||||       | .|..||||  | ..|| |. ... 
reefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkld....kps.psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkv

GIIVMITNLVEKGRRKCDQYWPTENSEEygniiVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPK-GRQnERVVIQYHYTQWPDMGVPEYALPVLTFVr
  |||. . || |. || ||||. . |      ..|||  .    .  .   |.....         | | .  | . ..|.||| |||   |  | .. 
eqivmlcktvelgklkcaqywpaaqgek.....lelksgivvenvsgskpmerdaeiqitllnltysgdq.kmsvrhlqwtewpdrgvppckltslell.

rsSAARMPeTGPVLVHCSAGVGRTGTYIVIDSMLQQIKD-KSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE
  || |     |..||||||.||||| . |. .|..| . |.   .  ..| .| || . .|.. ||.|||  .|. .| |  |
..sairgs.kvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyke
subfamily_CG42327_pd Subfamily CG42327 849-1041 2.8e-33 109.9 In-house 8-186 (319) alignment 
Range on Protein: 849-1041
Range on HMM: 8-186/319.0
SEDFEEVQRCTADMNitaehSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKhsDYINANYVDGYNKAK-AYIATQGPLKSTFEDFWRMIWEQNTGII
 |.|... .  |  .        .  | |.|.||..   ..|| |.  . .|..   |..|.|| ||..|.  |||.| .|...  ||||..|||.. .|
aeefrdlPqliarad.....evPvtskdksrvinvvPlPetrvvlqrigdddkd..eyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvi

VMITNLVEKGRRKCDQYWPTE----NSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkKgqkgnpkgrQNERVVIQYHYtQWPDMGVPEYALPVLTF
| .|.| |.| ..| .|.||.    | . ||.| ||||  ...  | .  . ... .  |         .. | .  | | .|.. .||    .... 
vqltdlselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvd..k.........eesrelthywy.kwleaevPaeeaaliam
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 849-914 4.4e-10 33.5 In-house 21-85 (440) alignment 
Range on Protein: 849-914
Range on HMM: 21-85/440.0
SEDF-EEVQRCTADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGkdSKHSDYINANYVDG
|  | .|     . .   .. .. |.|| |||| |||||||||| |  . |    .|||||| |..|
srafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkg..vpdsdyinasying
subfamily_PTPN14_pd Subfamily PTPN14 850-1119 1.3e-57 190.1 In-house 27-295 (300) alignment 
Range on Protein: 850-1119
Range on HMM: 27-295/300.0
EDFEEVQRCTADMNitAEHSNHPENKHKNRYINILAYDHSRVKLRPlpGKDSkHSDYINANYVDGY--NKAKAYIATQGPLKSTFEDFWRMIWEQNTGII
 ..|....  .| .   . .. |||..|||. ..| |...||.| |   |.. ...||||  .      | . ||..||||. | .|||.|.|||.. .|
teyeripkkredal..lstaklpenaeknrfkdvlPyednrvelsp..tken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqli

VMITNLVEKGRRKCDQYWPTE----NSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKgqkgnpkgrqnERVVIQYHYTQWPDMGVPEYALPVLTFVR
||.|.  |.|. |. .|.| .    .. |.|.  || | ..   ... . . ..    |.           || |.   || ||| ||||   . | ...
vmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpske...........ertvwhlqytDWpdhgvPeDvkgflsyLe

------RSSAARMP---ETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEA
      | .   ..   .  ||||||||||||||  |. | ... ..   ....   |...|.|| .||||  || |....|.. 
evqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 850-1123 3.2e-21 70.2 In-house 26-282 (303) alignment 
Range on Protein: 850-1123
Range on HMM: 26-282/303.0
EDFEEVQRCTaDMNITAEHsnHPENKHKNRYINILAYDHSRVKLrplpgkdsKHSDYINANYVDgYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVM
..||.|       ... ..    .| .|||.....  |||.|||          | || |.|..  .  |  | || ||  |  |||.|| ||.   ...
nefekvvsyl.ppsvsknq..fvknmdknrfvdvicldhskvkl........sdssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvll

ITNLVEKGRRKCDQYWPTENSeeYGNiiVTLKSTKIHACYTVRRFSIRNTKVKKGQKGNPKGrqnerVVIQYHYTQWPDMGVPEYALPVL--TFVR-RSS
.    |  .   |  .| ..   . .     .| ..     |      . ||    .|. |       .  .|| .||   .|  . | .     . .| 
lltdseydklggdsvfprnqd..flk..feersirvgefkrvelgdgwvlkvlsvsngdyks.....flhvhhykawphnsipsdgspkfvkqiwqlqsv

AARMPETGPVLVHCSAGVGRTGTYIVIDSM-LQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGK
  .  .. | .    .|.||.||. ....  |   .........  |. .|  | . ||   |. ...  | | .|..
lrkysdstptvymslsgcgragtfalfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldn
subfamily_PTPN3_pd Subfamily PTPN3 851-1119 2e-73 241.7 In-house 20-274 (280) alignment 
Range on Protein: 851-1119
Range on HMM: 20-274/280.0
DFEEVQRCTADMNITAehSNHPENKHKNRYINILAYDHSRVKLRplpgkDSKHsDYINANYVD----GYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGI
 ||.. |   ...|.|  .. ||| .|||| .||.||. ||||.     .|.  ||||||||.    . .  . ||||||||..| .|||.|.|||.. .
qfeqlyrkkpglaisa..arkpenlsknryrdilpydatrvklk.....eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkssl

IVMITNLVEKGRRKCDQYWPT-ENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKkgqkgnpkgrqNERVVIQYHYTQWPDMGVPEYALPVLTFVRRS
|||.|.|||.|| || ||||. |.. |||.. |...... .  | .| . ..... |           .|| ..|  |..||| |||. .  .|.||.| 
ivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketk...........eerkilqlqylaWpdhgvPddsadflefverv

SAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEA
 ..|  .. ||.||||||.|||| .|...  |. |  .  |..|  ....| ||  ||||..|| |. .|.|..
rklrsgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 853-1112 7.6e-33 108.5 In-house 30-273 (301) alignment 
Range on Protein: 853-1112
Range on HMM: 30-273/301.0
EEVQRCTAD-MNITAEHSNHPENkhKNRYINILAYDHSRVKLRplpgKDSKHSdYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMIT
|.|.  | |  .||  ..  |..  |.|| ..    .. |..     .| |    | ||...   ... .||||||||.| |||| |.   .   |||..
envnvttidkdhitesyaylpkd..khryptvPckPstavevi....vdGkrv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlg

NLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHACyTVRRFSIRNTKVKkgqkgNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAArmp
. |||  .||..| |.. ||.      ..| .. .      . | |. .|.     .  |. . | |. | |..|.| |||.    .  ..     .   
qkvekleekceeylpvkisekldigrfkikiknkeli.lnkkiskrtleve.....dstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks...

eTGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFI
   |..||||||.||. ..|  . . .... . |...   |||.| .|   |||..|  ..
.ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 859-1110 1.5e-17 58.1 In-house 19-292 (332) alignment 
Range on Protein: 859-1110
Range on HMM: 19-292/332.0
TADMNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDskhsDYINANYVDGYNKAKAYIATQGPLKSTFE-DFWRMIWEQNTGIIVMITNLVEKG
|. |     . .  .|   ||   . ..|||||.| |  |||    |. ||..||||.|  ||| .| |..   |  ||||. |..  .|... .. || 
tsamtypntydkflnnmdmnriphlycfdhsrvelapqdgkd....dfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekq

RRKC-----DQYWPTENSEEYGNIIVTLKSTKIHACYTV----------RRFSIR------NTKVKKGQKGNPKGRQNERVVIqYHYTQWPDM-GVPEYA
.||.     |. .      |.|   .     | . |  .            .||.      .|..|  .    . .|. . |.  |. .| |   .||| 
krkapydisdrgfeksflhefgaksleecelkakicrkfwpekrskkdfpalsiqasddhsethmktfnltvtekkqdhqtvl.mhfyewadasklpeym

LPVLTFVR----RSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYI
| . . ..    |||       ||... |..|| .   .  || .. .| ..  | .   .  |. ||   ..|   | 
ldmrasiklqyirsskktgvcigpimlvcatgvekcaisatidiivsriteehrvgfketmsaikmqrfgcfrtvgpys
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 861-1137 2.2e-83 275.1 In-house 11-272 (284) alignment 
Range on Protein: 861-1137
Range on HMM: 11-272/284.0
DMNI-TAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDskHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITnlvekgRR
 .|  . ...| ..|| |||...|||.|...|||..| |..   |||||| .. || . . ||||||||. | .||||||||.|.  ||..|      . 
gvngtdqtfanldqnkdknrighilafdknvvklerliGee..fsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kd

KCDQYWPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNtkvkkgqKGNPkgrQNERVVIQYHYTQWPDMGVPEYALPVLTFVRR--SSAARMPETGPVL
|| |||| .  .....  | ..| .  . |.|| . . .       .|.    .. | . |.|.  |||.|||.|. .....|..      .. .  ...
kcsqywplkivikeerfkvkvdsveeseeyvvrdielse.......dgke...kdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhraniv

VHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSSNQLHSYVN
|||||||||||.|||.| .|...|... |.|  |.. .| ||| |||   || ||. ||||  |   ..|.  .. .|..
vhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayle
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 862-1117 2e-74 245.1 In-house 16-265 (274) alignment 
Range on Protein: 862-1117
Range on HMM: 16-265/274.0
MNITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKdSKHSDYINANYVDGYN-KAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRK
.| . |. . . ...|||| .||  ..||| |..  .. .. |.||||||. ||. . |||.|||||| .| .||||||..... .|||.|.| |. ..|
lnfdqeeldvfgsqtknryktilPnensrvllesesse.dedssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqk

CDQYWPTEN----SEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGqkgnpkgrqnervVIQYHYTQWPDMGVPEYALPVLTFVRRSSA---ARMPET
| .|.|...    ||.||.. .. .... .  |.||........ ..              |. | ||.|||. .|. | ..| .|.  .    ..  ..
CavyfPdaedyeiserygdveikvekiverndysvrklvlkylerers.............vkhywytdWPdhksPddantlldlvleveesreeenakl

GPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALL
.||.||||||.|||| .| |.  ..|......|.||.   ..| .|  .|||.||| .|| || 
apvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
0049772 (Phosphotyrosine protein) phosphatases II 863-1126 8.5e-51 168.9 In-house 35-286 (314) alignment 
Range on Protein: 863-1126
Range on HMM: 35-286/314.0
NITAEHSNHPENKHKNRYINILAYDhSRVKLRPLPGKDskhSDYINANYVDGYnkaKAYIATQGPLKSTFEDF----------WRMI--WEQNTGIIVM-
. |   .....|..||||..|| .| .||.|  ||...   ||||||.||||.   ...|||||||. |..||          |||.  ...|. .||| 
eltilvadlflnrdknryldilpad.nrvilpglpvsg...sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivms

--------------------ITNLVEKGrrkcdQYWPTENSEEYGniivtlkstkihacytvrrfS-------IrntkvkkgqkgnpkgrqnERVVIQYH
                    ...| ..|      ... .. |..                     .                          || .|.|.
rdevladelsrLdaAlgKtpllildgng.....neptaadlellk....................eelydpelf..................erlgikyl

YTQWPDMGVP--EYALPVLTFVRRSsaarmPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKdkstVNVLGFLKHIRTQRN-----YLVQTEEQYIFIHDA
.. .|| ..|  |. . .| |...      .. |||||||.||.|||||..|.. .. . .    |..   |...| .|       .... |||.||..|
ripvpDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkllg....vsleealedvrlkRpinpnpgfieqleqyefilea

LLEAILGKETE
|||..  ....
lleylkflkkf
subfamily_egg_pd Subfamily egg 863-1124 3.7e-31 102.9 In-house 29-277 (307) alignment 
Range on Protein: 863-1124
Range on HMM: 29-277/307.0
NITAEHSNHPENKHKNRYINILAYDHSRVKLRPLPGKDSKhsDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKgrRKCD
.|. ...   .|..| |   .   | |||||.   |. .   |.| ||.|.|      .| .| ||| | .|||||.....   |||.|  .|    .|.
eislttaasdnnlekarskrvhckdssrvklelrrGqyld..dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erce

QYWPTENSEEYGNIIVTLKSTKIHACYTV-RRFSIRNTKVkkgQ--KgnpkgrqNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAarmpetgPVLVH
 |||  .|.    .  .|. . ..   .    | . . |.      .       .|   ...   ..  ..   . | ||  .|. |        ||.|.
yywpkaesdslvtvpGslrienlkvdskadplfrvtklkl...vGgd.......deerflehwqgdvnnssdvysplrvlrklrnlsk.......pvvvq

CSAGVGRTGTYIVIDSMLQQIKDKST--VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALL---EAILGKE
.  || ...| . |.  | ..    .    ||   . .| .|.. |..  .|.|..  .|     ..|  
dilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlfffrdvigsa
0045098 (Phosphotyrosine protein) phosphatases II 865-1122 6.2e-86 283.5 In-house 24-274 (278) alignment 
Range on Protein: 865-1122
Range on HMM: 24-274/278.0
TAEHSNHPENKHKNRYINILAYDHSRVKlrplpgkdskhsDYINANYVDGYnKaKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQY
. .... ..|..|||| .||.|||||||            |||||.|.||| . |..|||||||.||..|||||.||... .|||.|.|||.|| ||.||
eitpalylgnldknRykdilpydhsrVk............dYINAsyidgy.p.kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqy

WPTENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQkgnpkgrQNERVVIQYHYTQWPDMGVPEYA--LPVLTFVRRSSAARM------------
|| ..|..||.. |||.|.... .||.|.. ..|. |..           .| | ..||. |||.|||..    ..| ....  .|.             
wpeggsltygdftvtllseevlddytlrtllvtnltvered.......lesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslll

-PETGPVLVHCSAGVGRTGTYIVIDSMLQQIkdKSTVNVLGFLKHIRTQRNY-LVQTEEQYIFIHDALLEAILG
 .. ||||||||||||||||..... ||...  ...|..|  .|..|.||..  ||..|||.|....||| .| 
ldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_eak_pd Subfamily eak 865-1139 7.3e-22 72.2 In-house 43-326 (332) alignment 
Range on Protein: 865-1139
Range on HMM: 43-326/332.0
TAEHSNHPENKHKNrYINILAYDHSRVKLRPlpgKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQY
. . ..  |. ..|  ..|. ||.  |.| .       .  ||||  ..  .  . || |  . ..    ||.|. ||..  ||.. . ||..  | |.|
sisetarleavnrn.vvkivpydrylvrlts...sqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdky

WPTEN--SEEYGNIIVTLKSTKIHACYTVRRFSIRNTK-VKKGQKGNPKGRQNERVVIQY----HYTQWPDMGVPEYALPVLTFVRrSSAARM---PETG
.| .     ..| . |. |.   .. . .| . ..     .. .. .  |  .  . .       .    ..||.  . .  . .. |   .    | . 
fpdktreelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksalls.stlkkyihtppsf

PVLVHCSAGVGRTGTYIVIDSMLQQIKDKST--VNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVSS--NQLHSYVNSI
  .. .. |  |.|...||| ... | .| .    |  ..  ....|.. | .. |. ||....|. .| .. ..    ..| .| .|.
apiiqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdlkkyleayaesv
0040439 (Phosphotyrosine protein) phosphatases II 867-1121 2.7e-86 284.4 In-house 4-247 (249) alignment 
Range on Protein: 867-1121
Range on HMM: 4-247/249.0
EHSNHPENKHKNRYINILAYDHSRVKLRPLPGkdSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWP
.....||||.|||| .||.|||||||| .|||    .||||||.|.|||.  ...|||||||..|.||||||.||.. ..|||.|.|||.|| ||.||||
svallpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

TENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTkvkkgqkgnpkGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSA--ARMPETGPVLVHCSAGV
...| |||.. |||.|..... |||| . . |.           . ...| | ...|| |||.|||..  ..| |...     .. |. |||||||||||
lggsleygdftvtllsvevkddytvrtleltnl...........ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGv

GRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAIL
|||||.|... ||.|.. . .|...  .|..|.||.. ||..|||.|...|||| .|
gRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0042113 (Phosphotyrosine protein) phosphatases II 867-1118 3.3e-85 280.7 In-house 2-241 (245) alignment 
Range on Protein: 867-1118
Range on HMM: 2-241/245.0
EHSNHPENKHKNRYINILAYDHSRVKLRPLPGkdSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWP
.....||||.|||| .||.|||.|||| | .|  . .||||||.|||||.  . .|||||||..|.||||||.||..  .|||.|...|.|| ||.||||
svallpenkdknrysdilpydhtrvklspdgg..dldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywp

TENSEEYGNIIVTLKSTKIHACYTVRRFSIRNTkvkkgqkgnpkGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARM-PETGPVLVHCSAGVG
...| .||...|||.|..... |||| ... |.           |   .| ||.|||. |||.|||..   .| |...   |.  .. ||||||||||||
lgesltygdftvtllseehlddytvrtlevtnl...........gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvg

RTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
||||.|... ||.|..   .|..   .|..| ||   |||..||.|...||||
RtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 867-1132 9.9e-41 134.3 In-house 45-301 (310) alignment 
Range on Protein: 867-1132
Range on HMM: 45-301/310.0
EHSNHPENKHKNRYINILAYDHSRVKLRplpGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWP
 .  . .. ||||| ...  | |||||.      |.. ||| ||||      ...| .||||. |  ||||||... .  |... . .|.|| ||  |||
tyeaykkymhknrysdvvcldtsrvklk...idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywp

TE-NSEEYGNIIVTL---KSTKIHACYTVRRFSIRNTKVKKgQKGNPKgrqNERVVIqYHYTQWPDMGVPEYAlpVLTFVRRSSAaRMpETGPVLVHCSA
.   .| || | ||     | ..  |     |   |  | . |  | |   . || .  .. .|||.|||.    . |  .|  | ..   ||..|||||
slgvtetygcirvtnlsesseefeicnlavtfvpdnvpvde.qpanlk...elrvsl.ikwpnwpdrgvpdek..chtvpqrlla.qv.rhgpcvvhcsa

GVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAIlGKETEVSSNQL
|..|... . ..  .....    |..     ... .|   .||| ||..|.   .      ||||. . |
gkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriifa.rgetevaekil
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 867-980 1.4e-14 48.3 In-house 89-195 (244) alignment 
Range on Protein: 867-980
Range on HMM: 89-195/244.0
EHSNHPENKHKNRYINILAYDHSRVKLrplpGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKgrrkcDQYWP
. .  |.| .|||    | .| .|| |     | |    |||| .|    ..  || || ||  |  |||.|. |.   ..|..  . |.     |.|||
kdafnpnnswknregaglpfdfnrvpl....skgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....deywp

TENSEEY-G-NIIVTL
  .  |.   .| |||
dseplewyeeditvtl
0037934 (Phosphotyrosine protein) phosphatases II 868-1118 1.3e-79 262.4 In-house 4-240 (243) alignment 
Range on Protein: 868-1118
Range on HMM: 4-240/243.0
HSNHPENKHKNRYINILAYDHSRVKLrplpgkDSkhSDYINANYVDGYNKakaYIATQGPLKSTFED----FWRMIWEQNTGIIVMITNLVEKGRRKCDQ
....|||..|||| .||.||||||||      ..  |||||||.......   .|||||||..|.||    ||||.||.....|||.|.|||.|| ||.|
iallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPteNSEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGQkgnpkgrqneRVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAA--------RMPETGP
|||  ....||...|||.|.. .. |||| ....|.. .. .          | ||.|||. |||.|||.   ..| |..   .           .. ||
ywp..gevtygdftvtllseehlddytvrtlllenldlddlt..........rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggp

VLVHCSAGVGRTGTYIVIDSMLQQIkdksTVNVLGFLKHIRTQRNY-LVQTEEQYIFIHDALLE
||||||||||||||.|... ||...    .|...  .|..|.||..  |||..||.|...||||
vlVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 869-1118 3.3e-44 145.6 In-house 32-267 (281) alignment 
Range on Protein: 869-1118
Range on HMM: 32-267/281.0
SNHPENKHKNRYINILAYDHSRVKLRP-LPGKDSkhSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPT
 |.| |..||||.|| . | |||.|.  .| |.|  .||| |||.      . || |||| | |  |||||||..||  |||. ...|  | || .|.| 
fnqpvnnkknrylnipcldisrvqlkvkmpnkns..tdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfpr

enseeygNIIVTLKSTKIHACYTVR--RFSIRNTKVKKGQKGnpkgrqNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAaRmpETGPVlVHCSAGVG
       |  . |.  |.   |       |.  |...   .|      . |.. .. . .|||  ||| .  .|  .|.  | |   | || .|||||||
.......nahcclqfdklsvsyedstvnkslvttrlnlsyeg......etrlithwlwkewpdwqvpessevmlkilrkira.r..stppv.ihcsagvg

RTGTYIVIDSMLQQIKDKSTVN-VLGFLKHIR-TQRNYLVQTEEQYIFIHDALLE
|.|| . ..  || |. . |.  .   . |.| | |   ||| .||..|   ||.
rsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_ptpA1_pd Subfamily ptpA1 869-1080 6.4e-41 135.4 In-house 42-256 (418) alignment 
Range on Protein: 869-1080
Range on HMM: 42-256/418.0
SNHPENKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINANYVDGYnKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTE
 ..  |  |||| |||  .|.||.|. .  .| . ||||||||.||    | .|.|||||  |  |||||.||.   ||||..   |. | |||.||| .
gdkkhntsknrytnilpvnhtrvqlkki..qdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeq

NSEEYGNIIVtlKSTKIHACYTVRRFSIRNTKVKKGQKGNPK--GRQNERVVIQYHYTQWPDMGVPEYALPVLTFVR---RSSAARMPE---TGPVLVHC
   |  .|    .  ..   |.|    . .   ..    | .     . | . ||.|  |||  .|... |.  ...         .|      |..|||
iggeqfsiyg..ngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiivhc

SAGVGRTGTYIVIDSMLQQI
|||||||||.     |....
sagvgrtgtfctavimmkkl
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 869-1128 8e-40 131.7 In-house 38-279 (288) alignment 
Range on Protein: 869-1128
Range on HMM: 38-279/288.0
SNHPENKHKNRYINILAYDHSRVKLRplpgkDSKHsDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTE
... .|  ..|| |.   | .||||      |  .  ||.|| |   .  .  | .| ||..| | .|.|. |..   |||...|.|||..| ..|.|..
dsfianptrdryenlprcditrvkls.....ddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsk

NSEEYgNIIVTLKSTKIHAcYTVRRfSIRNTKVKKGQKGnpkgrQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSsaarMPETGPVLVHCSAGVGRTG
  |.   |    . .| .    . .  .. . ..  ..|     ... .| . |. .|.| ||||  |. | .. .        . |..||.||||||||
lGeka.rigrlctvvkkkr.adidk.lvkvsllriskeg.....eekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtg

TYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETEVS
| |.|  .|.... .  . .  .|.. | .|   .||| ||...|  .|| .| |  .|.
tlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkkykvl
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 869-1034 9.6e-34 111.6 In-house 28-182 (297) alignment 
Range on Protein: 869-1034
Range on HMM: 28-182/297.0
SNHPENKHKNRYINILAYDHSRVKLRPLPgkdsKHSDYINANYVDGYNKAK--AYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWP
.. .   .|||| .|||.| .||||.  .      .|||||.||   .. .   || .||||..| .|||....||. ..|||...| | || ||  |||
akrnsslrknryrdilatddtrvkllrvi....terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapywp

TENSE--EYGNIIVTLKSTKIHAcYTvrRFSIrnTKVKKGQKgnpkgrQNERVVIQYHYTQWPDMGVPEY
  . |  . |...|   |.     .   |  .  |...   .      ...|||    .  ||| |||  
svvqerlkagdvvveflsstsde.fd..rvil..telqliyr......sesrvvrhvqflswpdhGvpsd
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 869-1125 3e-32 106.7 In-house 30-275 (285) alignment 
Range on Protein: 869-1125
Range on HMM: 30-275/285.0
SNHPENKHKNRYINILAYDHSRVKLRplpgkdSKHSDYINANYVDGYNKA-KAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPT
. .  |   ||| .. . . .|| |.       .  ||| |...    |   .||.|||||  |. |||.||....   ..|.  |.| |  ||  |.| 
tayeanpdlnryadvrcieetrvvlk......nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyype

ENSE--EYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKGqKGNPKgrQNERVviqyHYTQWPDMGVPEYALPVLTFVRRSSAArMPETGPVLVHCSAGVG
.  |  ..|.  .||   |  |       ..  .. .     .|     ..|    .   |||   || | |.. . .       |.  |. ||||||||
klgevvkfgkyeitlteckeeaiagtilnaltvinteda.ssepl..ymnhv....qvpwwpdqlapedarpmielykwvkkv.npkekpicvhcsagvg

RTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKET
|| |.. ||    .| ..  ...|  .. .|. |   ||.  |..|..  |.| ..|.  
rtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfigegv
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 870-1120 2.2e-88 290.7 In-house 5-242 (250) alignment 
Range on Protein: 870-1120
Range on HMM: 5-242/250.0
NHPENKHKNRYINILAYDHSRVKLRPLPgkDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRkCDQYWPTEN
..|.||.|||| .|.|.|.||| | .      |.|||||| ...||.. ||.|||||||..|.||||||..|...| |||.|||.|...  . ||||.|.
kkpqnkeknryadiialdssrvvLekek..gdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

SEEYGNIIVTLKSTKIHACYTVRRFSIRNTKvkkgqkgnpkgRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMP-ETGPVLVHCSAGVGRTG
.|.||.. |.|.|....| ||.|.. . ..|           ...||.| |.|...||| ||||.|  || ....  | .   ...||.|.|||||||.|
aekyGdvtvsllskeefadytkrklklskak...........kaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsG

TYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
..|.||..|...| . .|.|  ..| .|..|   |...|||.|.. ..|.|.
afiaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkal
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 871-1118 8.9e-63 206.8 In-house 17-262 (270) alignment 
Range on Protein: 871-1118
Range on HMM: 17-262/270.0
HPENKHKNRYINILAYDHSRVKLRPLPGkdSKHSDYINANYVDGYNK-AKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTEN
.  .|. ||| .||   ..||.| .|     ... ||||||| |...  |.|||..|||..| ..|||||||...  |||.|.|.||||.||..|||.|.
aargkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaep

SE----EYGNIIVTLKSTKIHACYTvrrfsirNTKVKKGQKGnpkgrQNERVViQYHYTQWPDMGVPEYAL------PVLTFVRRS--SAARMPETGPVL
 |    |.|.| |.  |.. .  |         |...  .||     ...|.|  ..|..||| |||. .        .|. .|    |  .. ...|.|
kekvkledgkikvlalseekeegyi.......ltrlrleekg.....eerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePll

VHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
|||||||||||| |..| ... .. .. |.||  ....| .|  |||. ||| |.. |..|
vHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 872-1118 3e-72 237.7 In-house 1-237 (237) alignment 
Range on Protein: 872-1118
Range on HMM: 1-237/237.0
PENKHKNRYINILAYDHSRVKLRPlPGKDskhSDYINANYVDGYNK-AKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWP-TEN
.||| |||| || ||||||| |.  .| .   ||||||.|..|..   | |||.||||.|. .|||.|.|...  .|||.| |.|. . || .||| |..
senkiknrygnivaydhsrvvlkg.agsg...sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdq

SEEYGNIIVTLKSTKIHACYTVRRFSIRNTKVKKgqkgnpkgrqNERVVIQYHYTQWPDMGVPEYALPVLTFVRR--SSAARMPETGPVLVHCSAGVGRT
 . || . |.||  .  . |||| . . .   .|          . |.. ||..| ||| |||...  .| | ..    .  ..|.|| ..|||||||||
paaygvltvslkkkeefsdytvrslllskrltlk..........evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrt

GTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
| ..|||.||.| |.|  |..  ... |  .| |..||..||.|||...||
giflvidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 872-1126 7.7e-30 98.6 In-house 41-282 (312) alignment 
Range on Protein: 872-1126
Range on HMM: 41-282/312.0
PENKHKNRYINILAYDHSRVKLRplpGkDskHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWptenSE
   |  ||| ||  .|  |  |    | |     || ||.|    | . ...|||||..|   ||..     .  |.... .|| |  || .|     |.
lkfkdlnrypniqcwdrgrftla...g.d..enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyi....sd

EYGniIVTLKSTKIHA--CYTVRRFSIRNTKV-KKGQKGNPKGRQNERVVIQYHYTQWPDMGVPEYAlpvLTFVRRSSAARMpETGPVLVHCSAGVGRTG
  |  .| |.  ....  |  .      . |. ..  |   |   .|  . .| .. ||| |.|.      |  |  || .  .  ||. ||||||||||
ivg..fvdledhrvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdsc...dtalrllsavkk.dkkpviahcsagvgrtg

TYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE
| ..|.||.  ..     ||   .  .| .|   |..  ||..   ..|| .  |   
tlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskgly
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 872-950 1e-09 32.4 In-house 35-116 (347) alignment 
Range on Protein: 872-950
Range on HMM: 35-116/347.0
PENKHKNRYINILAYDHSRVKLRPLPGKDSKHS---DYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMI
  .  |||  .    | .|| | |   | |.      |||| ..   |  | || || || .|  |||.|.   .   .| |
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 872-1036 3.9e-09 29.7 In-house 25-159 (169) alignment 
Range on Protein: 872-1036
Range on HMM: 25-159/169.0
PENKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINAnyvdgynkakayiatqgplkstfedfwRMIWEQNTGIIVMITNLVEKgrrkcDQYWPTEnsE
  |. |||    ||  | ||||. .   .   ||||||                           ||||| |. .||.. .  .|     ...||    |
tcnetknrpagplapshtrvklqrv..medlgsdyina...........................rmiwetnasvivvlgdtddk.....nnfwpek..e

EYgniivTLKSTKIHACYTVRRFSIRNTKVKKGQKG-------NPKGRQNERVVI----QYHYTQWPDMGVPEYAL
.|      |. . |   .    . .|  ||..  .|       .    . .. |      .||. ||. |||.  .
dy.....qlhpavilgewytdslyvrtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpqspv
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 872-1038 4.2e-09 29.5 In-house 24-160 (169) alignment 
Range on Protein: 872-1038
Range on HMM: 24-160/169.0
PENKHKNRYINILAYDHSRVKLRPLpgKDSKHSDYINAnyvdgynkakayiatqgplkstfedfwRMIWEQNTGIIVMITNLVEKgrrkcDQYWPTEnsE
  |. |||    ||  | ||||. .   .   ||||||                           ||||| |. .||.. .  .|     ...||    |
tcnetknrpagplapshtrvklqrv..medlgsdyina...........................rmiwetnasvivvlGdtddk.....nnfwpek..e

EYG-NIIVTLKSTKIHACYtVRRFSIR-NTKVKKGQKGN--PKGRQNERVVI---QYHYTQWPDMGVPEYALPV
.|     | |      . | ||   .. ||   .|       ... .. |      .||. ||. |||.  . |
dyqlhpavilGewytdsly.vrtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvpqspvhv
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 873-1118 7.3e-75 246.2 In-house 7-239 (239) alignment 
Range on Protein: 873-1118
Range on HMM: 7-239/239.0
ENKHKNRYINILAYDHSRVKLRPLPgkDSKHSDYINANYVDGYNK-AKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSe
 || |||| ||..|||||| |  |   .  |||||||.|.  |.   |||||||| .. .  |||||.|..   .|||.| |.|  ..|| ||||   | 
vnkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.

EYGNIIVTLKSTKIHACYTVRRFSIRNTkvkkgqkgnpkGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYI
.| |. |||. |.. | | .| | . .            |. .|| | |||.| ||| |||.||  || . |. .   .| . | ..||||||||||...
kycnlrvtlrktevfadyiirtfvmsqv...........gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgafl

VIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
|||.||.| | . ||... ..| || .| ..||| |||.||| |.||
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 873-1117 7.2e-43 141.6 In-house 46-341 (350) alignment 
Range on Protein: 873-1117
Range on HMM: 46-341/350.0
ENKHKNRYINILAYDHSRVKLR--PLPGKDSKH----SDYINANYVDGY------NKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRK
|   |||| ||| |.||||||.  . . .  ||    .|||||||.         |    |||||.||.||..||...| . .  .|...|..|| ...|
elfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlek

CDQYWPTENseeYGNIIVTLKSTKIHACyTVRRFSIRNTKVKKGQK------GNPKGRQNE------------RVVIQYHYTQWPDMG---VPEYALPVL
|..||.  .   | .| | |.|..   .  ..  |.. ..|||          . . ..|.             || | .. .|.|..    ||  |..|
cyrYWqegs...ydditvklaskwenim.gindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqal

T----FVRRSS---AARMPETGPVLVHCSAGVGRTGTYIVIDSMLQ------QIKDKST-V--------NVLGFLKHIRTQRNYLVQTEEQYIFIHDALL
     ..            .. |.|||||||||||||.. .||.|.      .....|. .         .   ....| ||  .||. .|.|||..|||
evkndliddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 873-1014 2.1e-22 73.9 In-house 47-198 (349) alignment 
Range on Protein: 873-1014
Range on HMM: 47-198/349.0
ENKHKNRYINILAYDHSRVKLR--PLPGKDSKHS----------DYINANYVD--GYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGR
|   |||| .|| |.||||||.  . . | .|.|          |||||||.    ..  | ||||| || || .||...|  ..  ... ...  |.. 
elfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelsl

RKCDQYWpteNSEEYGNIIVTLKSTKIHACyTVRRFSIRNTKVKKGQKGNPKGRQN
.|||.||   .  .| || | |. .  ...  |.  | |  .||. .. |   ..|
ekcdiyw...qelsysnitvklqnsslyia.nvqGnslrvstvkdtdndndnnkkn
Y_phosphatase Protein-tyrosine phosphatase 874-1118 2.5e-91 300.7 Pfam-A 1-235 (235) alignment 
Range on Protein: 874-1118
Range on HMM: 1-235/235.0
NKHKNRYINILAYDHSRVKLrplpGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWP--TENSE
||.|||| .||.||..||||     .....|||||||||.||.. |..||||||||||.||||||.|.... .|||.|.|.||||.||.||||  .|.|.
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EYGNIIVTLK-STK-IHACYTVRRFSIRNTKVKKgqkgnpkgrqNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGT
.||.| |.|| ..| ... ||.| ......| ..          ..| | |.|||.||| |||| . ..| ..|.    . ...|||.||||||||||||
tygdikvelkekekedekeytlrklelkkkkees..........ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgt

YIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
....| .|.|......|.|| ..|..|.||. .||..|||||...|.||
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 874-1118 2.5e-91 300.7 In-house 1-235 (235) alignment 
Range on Protein: 874-1118
Range on HMM: 1-235/235.0
NKHKNRYINILAYDHSRVKLrplpGKDSKHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWP--TENSE
||.|||| .||.||..||||     .....|||||||||.||.. |..||||||||||.||||||.|.... .|||.|.|.||||.||.||||  .|.|.
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EYGNIIVTLK-STK-IHACYTVRRFSIRNTKVKKgqkgnpkgrqNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGT
.||.| |.|| ..| ... ||.| ......| ..          ..| | |.|||.||| |||| . ..| ..|.    . ...|||.||||||||||||
tygdikvelkekekedekeytlrklelkkkkees..........ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgt

YIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLE
....| .|.|......|.|| ..|..|.||. .||..|||||...|.||
fvaldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 874-1119 2.4e-75 247.7 In-house 7-239 (239) alignment 
Range on Protein: 874-1119
Range on HMM: 7-239/239.0
NKHKNRYINILAYDHSRVKLRPLPgkDSKHSDYINANYVDGYNK-AKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSeE
|| |||| ||..|||||| |  |   .  |||||||.|.  |.   |||||||| .. .  |||||.|..   .|||.| |.|  ..|| ||||   | .
nkaknryanivtydhsrvvlekls..ndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.k

YGNIIVTLKSTKIHACYTVRRFSIRNTkvkkgqkgnpkGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIV
| |. |||. |.. | | .| | . .            |. .|| | |||.| ||| |||.||  || . |. .   .| . | ..||||||||||...|
ycnlrvtlrktevfadyiirtfvmsqv...........gqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflv

IDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEA
||.||.| | . ||... ..| || .| ..||| |||.||| |.|||
idamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
0041856 (Phosphotyrosine protein) phosphatases II 874-1126 5.3e-56 184.4 In-house 1-177 (182) alignment 
Range on Protein: 874-1126
Range on HMM: 1-177/182.0
NKHKNRYINILAYDHSRvklrplpgkdskHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITnlvekgrrkCDQYWPTENseey
|..|||| .|| |||||            ..||||||...|. .|. .|||||||.||..||.||..|.. ..||..|         ...|||..     
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell....

gniivtlkstkihacytvrrfsirntkvkkgqkgnpkgrqnERVVIQYHYTQWPDMGVPEyALPVLTFVRRSSAarmpETGPVLVHCSAGVGRTGTYIVI
                                         || .|||.|..|||.|||.    .| |...  .    | ||||||||||||||||....
.........................................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaa

DSMLQQikdksTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAILGKETE
. |...      |..   .|..| .|.  |.|..||.|...|||| .|.|.|.
ylmkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkktr
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 884-1120 9.4e-21 69.0 In-house 39-221 (255) alignment 
Range on Protein: 884-1120
Range on HMM: 39-221/255.0
LaydhsrvklrplpgkdskhsdyinanyvdgynkakayiatqgplksTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKST
|                                              | . |...|  ..|  .||.... |.|. ||..|.|.|  |      |.. .|
l..............................................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvttt

KIHACYTVRRFSIRNTKvkkgqkGNpkgRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARmpetgPVLVHCSAGVGRTGTYIVIDSMLQ----Q
|  |   .|   |  |       |.   ... . |  |.|. |..   || |  .|  ..    ..     .|.||||.|.||. ........ |    .
kssadvvlrtleitstl......ge...kkkthtvkhysykGWieknaPelareilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirs

IKDKSTVNV--LGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
..  .||..  | .|...| .|.  ..|  |  |    .|. .
ldttetveldylslleelrskrkraihtPlqlafsilmvldlv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 884-984 9.1e-11 36.2 In-house 3-88 (130) alignment 
Range on Protein: 884-984
Range on HMM: 3-88/130.0
LAYDHSRVKlrplpgkdskHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKgrrkcDQYWPTENSEEYGNIIVTLKST
| .. ||..            .||||..|   .... |. || ||  |  |||.|. |.   ..|..  . |.     |.|||  .  |. .  ... .|
lefevsrlq..........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePlewyeediivtlt

K
.
d
0044763 (Phosphotyrosine protein) phosphatases II 886-1116 9.3e-40 131.5 In-house 2-167 (178) alignment 
Range on Protein: 886-1116
Range on HMM: 2-167/178.0
YDHSRVKLRPLPGKDSkhSDYINANYVDGYnkakAYIATQGPlkstfEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSeeygniivtlkstki
.|..||.| .|.|  .  ||||||......     |.....|     .|......|.. . ||..|. .| |. |||.|||.|..               
ldrtrvllsnlegler..sdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

hacytvrrfsirntkvkkgqkgnpkgrqnervvIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQikdksT
                                 |||... .||.|||.    .| ||.   .|. .. |||||||||||||.|| .... |...      
.................................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....g

VNVLGFLKHIRTQRNyLVQTEEQYIFIHDAL
...   ....| .|.  |....|. ....  
lsleeaielvrerRp.ivpnpgqlrqLyefe
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 888-1117 1.3e-16 55.6 In-house 32-256 (290) alignment 
Range on Protein: 888-1117
Range on HMM: 32-256/290.0
HSRVKLRPLpgKDSKHSDYINANYVDgYNKAKAYIATQGPLK-------STFEDFWRMIWEQNTGIIVMITNLVEKGRR----KCDQYWPTENSEEygni
..|| |.    .    .||| ||.|  . .  . |.|| |..       || |.|| |. . .   .||. .  || .      | .| |..  ||    
atrvvLkgy..gkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgee....

iVTLKSTKIHACYTV--RRFSIRNTKVKKGQkgnpkgrQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSaarmPETGPVLVHCSAGVGRTGTYIVID
 ...|  ... .  .    . .|.  || ..       ..|  |  . . .| .. |.|  . .|. ..        .. ||.|||  |. |  .   |.
.lkfkgltvkCkskekeddvetRelvvkfdd.......eeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaii

SMLQQIK-DKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALL
   | |   .. |..   || .| ||. ........ |.  ...
lgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv
0046846 (Phosphotyrosine protein) phosphatases II 901-1118 7.2e-45 148.2 In-house 9-171 (176) alignment 
Range on Protein: 901-1118
Range on HMM: 9-171/176.0
SKHSDYINANYVDGYnkakAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYgniivtlkstkihacytvrrfsirntk
  ..||||||...|.    ..||||||| .|..||..|..|.. ...|..|..||.|| ||..||| . ....                           
dldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

vkkgqkgnpkgrqnervviQYHYTQWPDMGVPEYaLPVLTFVRRSSAARMPEtGPVLVHCSAGVGRTGTYIVIDSMLQqikdKSTVNVLGFLKHIRTQRN
                   ||... |||.|||..   .|....    |.    ||||||||||.|||||..... .      .  ..|.  |...| || 
...................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllel....ekglsveealalvreqRp

-YLVQTEEQYIFIHDALLE
 . |||.||| |.....|.
lgavqtpeQyrflyefell
0043147 (Phosphotyrosine protein) phosphatases II 902-1113 2e-45 149.9 In-house 3-154 (172) alignment 
Range on Protein: 902-1113
Range on HMM: 3-154/172.0
KHSDYINANYVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLvekgrrkcdqywptenseeygniivtlkstkihacytvrrfsirntkv
..||||||.|.|.| . . .||||||| .|..|||||..|.. ..||..|.|                                                
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

kkgqkgNPKGRQNERVVIQYHYTQWPDMGVPeYALPVLTFVRRSSA-ARMPETGPVLVHCSAGVGRTGTYIVIDSMLqqikdkSTVNVLGFLKHIRTQRN
         . . || .|||.|. |||.|||  .  .| |..     .   . |||||||||||||||| .... ||        ....  ....|..|.
......lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRp

YLVQTEEQYIFIH
. ||...||.|..
gavqnpsqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 903-1121 5.2e-55 182.3 In-house 3-226 (272) alignment 
Range on Protein: 903-1121
Range on HMM: 3-226/272.0
HSDYINANYVDGYNK---AKAYIATQGPLKSTFEDFWRMiWEQNTGIIVMITNLVEKGRRKCDQYWP------------TENSEEYGNIIVTLKSTKIHA
 |.||||..|.||..    .......|||. | .||||. .|..   ||......|.|| |||.|||            .. . .||.. ||| |.... 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

CYTVRRFSIRNTKVkkgqkgnpkgRQNERVVIQYHYTQWPDMGVP-EYALPVLTFVRRssaarmpeTGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTV
.|..|.. ....             .. | | ..|||.|||.||| |. | .| ....         ||||||||||..||||..... .|... .   |
dyilrellltllls..........agearevmhlhytdwpdhgvpqeallellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletiv

N--------VLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAIL
.        ........| || . |||||||.|...||||.. 
ddYlltnlyleeaveelraqrpgavqteeqylflyeallellr
0051082 (Phosphotyrosine protein) phosphatases II 903-1117 3.1e-37 122.8 In-house 2-150 (151) alignment 
Range on Protein: 903-1117
Range on HMM: 2-150/151.0
HSDYINANYVDGYnkakaYIATQGPlkstFEDFWRMIWEQNTGIIVMITNLVEKGrrKCDQYWPTENseeygniivtlkstkihacytvrrfsirntkvk
.|||||..||.|.     .....||     .||.....|..   ||......| |  .| .|.| ..                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

kgqkgnpkgrqneRVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAarmPETGPVLVHCSAGVGRTGTYIVIDSMLQQikdkstVNVLGFLKHIRTQRNYL
             . |...... ||| |.|..   || |..   .   .. ||||||||||.||||| .... ||..      |..   |...| .| ..
.............ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgv

VQTEEQYIFIHDALL
||...|..|.. |||
vqpnqqflfqlfall
0036282 (Phosphotyrosine protein) phosphatases II 904-1114 3.1e-50 165.6 In-house 2-164 (174) alignment 
Range on Protein: 904-1114
Range on HMM: 2-164/174.0
SDYINANYVDGYNKAKAYIATQGPLKstfedFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTenseeygniivtlkstkihacytvrrfsirntkvkk
||||||...|..   . .||.||||.     ||.|..|..  ..|| ....|.|. || .|||.                                    
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

gqkgnpKGRQNERVVIQYHYTQWPDMGVPEYALpVLTFVRRSSAARMP-ETGPVLVHCSAGVGRTGTYIVIDSMLQQIKdKSTVNVLGFLKHIRTQRNYL
      .    || .|||.|. |||.|||. .  .|.||..   |.   . |||||||||||||||| .... ||....  |.|..| ... .|.|| . 
......lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgm

VQTEEQYIFIHD
|||..||.|...
vqtpsQyrflyy
subfamily_hpo-7_pd Subfamily hpo-7 907-1117 8.5e-18 59.2 In-house 42-224 (263) alignment 
Range on Protein: 907-1117
Range on HMM: 42-224/263.0
InanyvdgynkakayiatqgpLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEEYGNIIVTLKSTKIHAcytvrrFSIRNTKVKKGQK
.                    |  | . |...|  ..|  .||...  |.|. ||..|.|.|  |      |.. .||.          .  |..   . 
l....................lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs......dvllktlellstl

GNpKgrQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARmpetgPVLVHCSAGVGRTGTYIVIDSMLQ----QIKDKSTVNV--LGFLKHIRTQRN
|. |  .. . | .| |. |..   || |  .|  ..     .     .. ||||.|.||.  . |.... |    ...  |||..  | .|...| .|.
ge.K..kkthtvkhysykgWiekndpelareilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrk

YLVQTEEQYIFIHDALL
  ..|  |  |    .|
raihtPmqLafsilmvL
0049260 (Phosphotyrosine protein) phosphatases II 911-1114 6.1e-45 147.9 In-house 1-144 (152) alignment 
Range on Protein: 911-1114
Range on HMM: 1-144/152.0
YVDGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWptenseeygniivtlkstkihacytvrrfsirntkvkkgqkgnpk
..|||.. ...||||||.  |..|||||..|.. ..|||.|.|.|.|. ||.||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

grqnervviQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLqqikdkSTVNVLGFLKHIRTQRNYLVQTEEQYI
         ||....|||.|||. .  .| ...    ..  . ||||||||||||||||..... ||        |... .....|..|.. |....|..
.........qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlr

FIHD
|...
flye
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 913-1124 9.7e-27 88.2 In-house 84-292 (302) alignment 
Range on Protein: 913-1124
Range on HMM: 84-292/302.0
DGYNKAKAYI-ATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENSEE--YGNIIVTLKST--KIHACYTVRRFSIRNTKVKKGQKG
|| .| .        | ||| | .| .| . |..|.| ....||.. .|| .|. ..  .|  .|.  |. .|   ...     . | . . ..|  .| 
dGtekkekvskkpivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkk

NpkgRQNERVVIqYHYTQWPDMGVPEYALPVLTFVRRSSAARMpetgPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEE
.   ...  | |  ... ||| | |. | . |  ..   . .      |||||||||||||| . |   .|  . | . ..|  .. .|. |   ||.|.
k...kvkktvdi.lafsawpdhGapkeaytaldilkfcesykk....nvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeq

QYIFIHDALLEAILGKE
| |..   .  ... |.
qliylllcvtkglmeka
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 913-991 1.6e-11 38.2 In-house 230-306 (440) alignment 
Range on Protein: 913-991
Range on HMM: 230-306/440.0
DGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKgrrKCDQYWPTE-NSEEYGNIIVTLKSTKIHACYTV
.|| | .|.|||| || ||  ||||.. . .   |.|. .| .|    |  ||| .  |  .| . |  | ..      |
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 918-1113 3.5e-23 76.8 In-house 4-197 (199) alignment 
Range on Protein: 918-1113
Range on HMM: 4-197/199.0
AKAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENS--EEYGNIIVTLKSTKIHACYTVRRFSIRNTKVkkgqkGNPkgrqNE
 . ||||| ||. |. |||.|.||  .| |||. .   .       |||| .|   .||.. || |.   .. ||.  . . |          |      
qrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntt.....app....st

RVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAAR---MPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKD--KSTVNVLGFLKHIRTQRNYLVQTEEQYI
| . .| .| | .   |. || |   |     ..        ||.|||| | | || .. .|  ..  ..   | |...   | .|  |  .. . ..| 
reishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhyn

FIH
||.
fiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 919-1113 3.9e-23 76.6 In-house 4-196 (198) alignment 
Range on Protein: 919-1113
Range on HMM: 4-196/198.0
KAYIATQGPLKSTFEDFWRMIWEQNTGIIVMITNLVEKGRRKCDQYWPTENS--EEYGNIIVTLKSTKIHACYTVRRFSIRNTKVkkgqkGNPkgrqNER
. ||||| ||. |. |||.|.||  .| |||. .   .       |||| .|   .||.. || |.   .. ||.  . . |          |      |
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnntt.....app....str

VVIQYHYTQWPDMGVPEYALPVLTFVRRSSAAR---MPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKD--KSTVNVLGFLKHIRTQRNYLVQTEEQYIF
 . .| .| | .   |. || |   |     ..        ||.|||| | | || .. .|  ..  ..   | |...   | .|  |  .. . ..| |
eishyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf

IH
|.
iy
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 929-1121 9.3e-07 21.7 In-house 128-310 (346) alignment 
Range on Protein: 929-1121
Range on HMM: 128-310/346.0
KSTFEDFWRMIWEQNTGIIVMITNlVEKGRRKCDQYWPTENseeyGNIIVTLKstkIHacYTVRRFSIRNTKVKKGQKGNPKGRQNERVVIQYHYTQWPD
.|  |||| ||....  .. ..    .| .      .  ||    |    | |   .      ||  .     .   .  |.|  .  ..  .|.. |  
esfvedfwymiyqeqihlvylmvp.ddklkntttslfnden....ggyqytgk...mf..innrradvsgdpkeytievlpegnsdsvicqvhhhapwkh

MGVPEYALPVLTFVRRSSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAIL
.  |  .||.. .. .  . .  ..  | |    | ||. ..|     ..|. .    |..  .| |. ||   |..  ||  |.  ... | 
lqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyia
0048076 (Phosphotyrosine protein) phosphatases II 979-1117 7e-26 86.0 In-house 24-140 (145) alignment 
Range on Protein: 979-1117
Range on HMM: 24-140/145.0
TLKSTKIHACYTVrrfsirntkvkkgqkgNPKGRQNERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPEtGPVLVHCSAGVGRTGTYIVIDSMLQ
.||. .| . ...                 .  .  || .|||.|. |||.|||. .  .|.|..   .|.  . ||||||||||||||||..... ||.
llkdlgittvlnl................tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll

qikdkSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALL
       |..   |...|.|| . |....|..|.....|
.....lgvsleealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 1008-1114 9.4e-25 82.4 In-house 48-139 (144) alignment 
Range on Protein: 1008-1114
Range on HMM: 48-139/144.0
NpkgrqnervVIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMpETGPVLVHCSAGVGRTGTYIVIDSMLqqikdKSTVNVLGFLKHIRTQRNYLVQTEE
.         .|||... |||.|||...  .|.|..   .|.  | ||||||||||||||||..... |.     |  ...   |...|..| . |....
e.........giqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpgavpnpg

QYIFIHD
|..|...
qlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1015-1161 9.7e-29 94.9 In-house 88-236 (440) alignment 
Range on Protein: 1015-1161
Range on HMM: 88-236/440.0
ERVVIQYHYTQWPDMGVPEYALPVLTFVRRSSAA-RMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIH
 |.. ||||  ||| |||..| ||| ...  . .      ||.|||||||.||||  |..||.|.. |    .... |.. .| .|  .||| ||| |.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

DALLEAILGKETEVSSNQLHSYVNSILIPGV-GGKTRLEKQFKLVTQCN
.|.||..|  .| .  ...   |. |  |     |. |...|.  .. |
eavlegllcgdtliledditerveqiqwpnphtdksplqqefegyskkn
0038934 (Phosphotyrosine protein) phosphatases II 1015-1072 3.9e-07 25.4 In-house 76-134 (194) alignment 
Range on Protein: 1015-1072
Range on HMM: 76-134/194.0
ERVVIQYHYTQWPDMGVP---EYALPVLTFVRRSSAArmPETGPVLVHCSAGVGRTGTYIV
|.. |.|.  ..|| |..   |  |  | .| .  ..   . | |.||| ||.||||| ..
ekagieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlva
PTPc_DSPc_SM00012 1018-1118 8.6e-35 114.5 In-house 2-105 (105) alignment 
Range on Protein: 1018-1118
Range on HMM: 2-105/105.0
VIQYHYTQWPDMGVPEYALPVLTFVRRSSAARMPE--TGPVLVHCSAGVGRTGTYIVIDSMLQQIKDK-STVNVLGFLKHIRTQRNYLVQTEEQYIFIHD
| .||||.|||.||||.. ..|...|     .  .  ..||.||||||||||||....| .|||.... ..|... ..|..|.||. .|||||||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

ALLE
||||
alle
subfamily_PTPDC1_pd Subfamily PTPDC1 1018-1114 7.5e-07 23.8 In-house 82-170 (182) alignment 
Range on Protein: 1018-1114
Range on HMM: 82-170/182.0
VIQYHYTQWPDMGVPEYAlPVLTFVRRSSAARmpETGPVLVHCSAGVGRTGTYIVIdsMLQQIKDKSTVNVlgfLKHIRTQRNYLVQTEEQYIFIHD
 | ..   |.| ||.     .|. |.  . |   . | | ||| || ||||  |    .|   |. .. .    .| .| .|   .|| ||  ....
giyvynfgwkDygvasle.riLdivkvvafal..qegkvavhChaGlGrtGvliac..ylvyakrltaeka...iklvrskrpksiqtreqvelvke
PTEN_1 1019-1071 2.2e-06 22.6 In-house 95-148 (196) alignment 
Range on Protein: 1019-1071
Range on HMM: 95-148/196.0
IQYHYTQWPDMGVPEYALpVLTFVRRSSAA-R-MPETGPVLVHCSAGVGRTGTYI
..|.   ..| |.|  .  .. ....   . .  |. . ||||| ||.||.|| .
veylhfpieDhgapslse.lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvv
PTPc_motif_SM00404 1037-1096 6.9e-06 21.0 In-house 68-121 (140) alignment 
Range on Protein: 1037-1096
Range on HMM: 68-121/140.0
PVLTFVRRSsaarMPETGPVLVHCSAGVGRTGTYIVIDSMlqQIKDKSTVNVLGFLKHIR
 ||.|....      . | ||||| ||| |..| |.   |  . .  |. ... |.|. |
kvldfiena....ekkggkvlVHCqaGvSRSatliiaYlm..ryrqlslaeayefvkerR
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1045-1120 3.8e-17 57.1 In-house 220-295 (297) alignment 
Range on Protein: 1045-1120
Range on HMM: 220-295/297.0
SSAARMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI
|  | ||   ..||||||||||.|  .  | .|.... |   .|  .|...| ||  |||| ||. ...|| |. .
slraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_CG42327_pd Subfamily CG42327 1049-1116 4.7e-14 46.8 In-house 243-311 (319) alignment 
Range on Protein: 1049-1116
Range on HMM: 243-311/319.0
RMPETGPVLVHCSAGVGRTGTYIVIDSMLQQIKDK-STVNVLGFLKHIRTQRNYLVQTEEQYIFIHDAL
.  . ||. |||| ||||||. |  |  ......   .|..   . ..| .|   |.| ||| ||.  |
tresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1053-1118 1.4e-08 28.4 In-house 265-342 (349) alignment 
Range on Protein: 1053-1118
Range on HMM: 265-342/349.0
TGPVLVHCSAGVGRTGTYIVIDSMLQ----QIKDKSTVNVLG--------FLKHIRTQRNYLVQTEEQYIFIHDALLE
. ..||||||| ||||... .|..|.      ..   ...           . ..| ||  .||   |.|.|..|||.
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLk
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1057-1121 3.7e-16 53.3 In-house 2-67 (69) alignment 
Range on Protein: 1057-1121
Range on HMM: 2-67/69.0
LVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI-L
.||||.| |||||.| |   . .|| .  |...  ....|  |  .|  | .|||||||| ||. |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealkl
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1058-1122 1.3e-15 51.5 In-house 2-67 (69) alignment 
Range on Protein: 1058-1122
Range on HMM: 2-67/69.0
VHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYLVQTEEQYIFIHDALLEAI-LG
||||.| |||||.| |   . .|| .  |...  ....|  |  .|  |..|.|||||| ||. ||
vhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealklG
0051299 (Phosphotyrosine protein) phosphatases II 1124-1410 8.3e-75 247.2 In-house 2-285 (288) alignment 
Range on Protein: 1124-1410
Range on HMM: 2-285/288.0
ETEVSSNQLHSYVNSILipgVGGKTRLEKQFKLVTQCNAKyVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIIT
.||.| ..|...|. .|    .|.|.|...|. ....... ... .|....|.||||.|...| .. || | .|.|. |.|||||||| ||.....||.|
dteisveellklvlkll...angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIat

QHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPSrEESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEAT----QDDYVLEVRHFQCPK
|.|||.|..|||||.|..| ..|||| . . |  |. . |||. ..|.... .||||.| .      .. .... .... .    .|.....|.||....
qgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.....lddytvrtlevtnldlldgdgesrtvthfhytn

WPNPDAP--ISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
||. ..|  ... ..... ...    ..||..||   |   .|...|| .| .|||.|. |||... |..  .|||...  |||.|.|.|.| .
wpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley
0043336 (Phosphotyrosine protein) phosphatases II 1132-1409 1.8e-68 226.3 In-house 4-275 (278) alignment 
Range on Protein: 1132-1409
Range on HMM: 4-275/278.0
LHSYVNSILIPGVGGKTRLEKQFKLVTQCNAkyVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTT
 ..... .| .. ..||.|...|. .....    ..  |....||.||| ....| .. || | .|.|  ..|||||||. || ....||.||.|||.|.
vkdllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

KDFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPsrEESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISS
.|||||.|... ..|||| .   |  .  . |||  ..|.... |||||.. .      .. ...... .. ..|.....|.|.....||  ..|  .|.
edFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeeh.....lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsl

TFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
 ........|   ...||..||   |   .|...|| .| .|||.|  ||.... |... .||| ..  .||.|.|.|.| 
lldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
0045450 (Phosphotyrosine protein) phosphatases II 1137-1411 2e-66 220.2 In-house 16-304 (307) alignment 
Range on Protein: 1137-1411
Range on HMM: 16-304/307.0
NSILIPGVGGKTRLEKQFKLVTQCNAK-YVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGM-KGTDYINASYI--------MGYYRSNEFIITQHP
  .|.    ..|.|.|.|. . ... . . |. .|....||.||| ....| .. || | .|.|. ...|||||||.         ||.....||.||.|
llvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqgP

LPHTTKDFWRMIWDHNAQIIVMLPDNQSLAE-DEFVYWPSREESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEAT-QDDYVLEVRHFQCPKWPNPDA
||.| .|||||.|... ..|||| .   |.    . |||. .|..... |||||.|..      .. .... . .. . .......|.||....||. ..
lpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.....ldgytvrtlevtdldgtgesrtvthfhytgwpdhgv

P--ISSTFELINVIKE--EALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENA---VDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV
|  .......|. ...  |.|...||..||   |   .|...|. .. .|||.|.    ||.... |..  .|||...  |||.|.|.|.| |.
ppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0039614 (Phosphotyrosine protein) phosphatases II 1141-1414 6.5e-65 214.8 In-house 25-292 (297) alignment 
Range on Protein: 1141-1414
Range on HMM: 25-292/297.0
IPGVGGKTRLEKQFKLVTQCNAkyvECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGM-KGTDYINASYIMGYYR-SNEFIITQHPLPHTTKDFWRMI
.    .||.|...|. . ...    ..  |....||.||| ....| .. || | |..|.  ..|||||||. ||.. ...||.||.|||.|..|||||.
lekansktllllefeellslkp...dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedFwrmv

WDHNAQIIVMLPDNQSLAEDEFVYWPSREEsmNCEAFTVTLISKDRlclsnEEQIIIHDFILEAtqDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVI
|... ..|||| .   |    . |||....  ... |||||.. .      .. ...  . ..   ......|.|||...||  ..|  ... .|... .
weqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkveh.....ldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelv

KE--EALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTK
.|  ..| ..||..||   |   .|...|. .. .||| |  |||... |... .|||...  .||.|.|.|.| |...|
realaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1141-1415 4e-56 185.4 In-house 19-287 (319) alignment 
Range on Protein: 1141-1415
Range on HMM: 19-287/319.0
IpgvGGKTRLEKQFKLVTQCNAKyvECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWD
     |.| |||.|||. . ...  .  ||.|| ||.||| . ... .|.|| |..|.|..|.||||||.| || . ..|| || || .|..|||||.|.
s...tgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWe

HNAQIIVMLPDNQSLAEDEFVYWPSREESMNCEAFTVTLISKDRLclsneEQIIIHDFILEATQDDY-VLEVRHFQCPKWPNPDAPISST--FELINVIK
... |.||| . .   . ..   ...|. ..   ..||| ....|     |..|| .. |.  ...    || |||  .||. | | ..|   .|.. |.
eessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeel.....edyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrir

EEAL-TRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKE
.    | .|| .||   |.   |  ..|    .....|...|||...... . |. .    |||.|||.|.|  |.. .
ksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd
0047943 (Phosphotyrosine protein) phosphatases II 1142-1409 6.1e-70 231.1 In-house 6-270 (273) alignment 
Range on Protein: 1142-1409
Range on HMM: 6-270/273.0
PGVGGKTRLEKQFKLVTQCNAkYVECFSAQKECNKEKNRNSSVVPSERARVGLaplpGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDH
 .  |.|.|...|.|....   ....  |....||.|||.....| .. || |    |..|.|||||||. ||.....||.||.|||.|..|||||.|..
ekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweq

NAQIIVMLPDNQSL-AEDEFVYWPSREE--SMNCEAFTVTLISKDRlclsnEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVI
|...|||| . ..|  |. . |||. ..  |.... |||||.| .      .. .... ..|. ........|.||....||. ..|  ..| .|.|...
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.....kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

KEEALT--RDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
..   .  ..||..||   |   .|...|| .| .||| |. |||... |..  .|||...  |||.|.|.|.| 
rkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle
0036941 (Phosphotyrosine protein) phosphatases II 1143-1415 8.2e-68 224.2 In-house 8-281 (297) alignment 
Range on Protein: 1143-1415
Range on HMM: 8-281/297.0
GVGGKTRLEKQFKLVTQCNAkYVECFSAQKECNKEKNRNSSVVPSERARVGLaplpGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHN
.  ....|.|.|. .... . . ..  |....|.|||| ....| .. || |    .  |.|||||||. ||.....||.||.|||.|. |||||.|..|
kllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqn

AQIIVMLPDNQSL-AEDEFVYWPSR-EESMNCEAFTVTLISKDRLclsNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKE
 ..|||| .  .|  |  . |||.  .||.... |||||.| .     ... .... . .. |.......|.||....||  ..|  ..| ...|. ...
vtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv...llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

--EALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLE---NENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKE
  ..|...||..||   |   .|...|. .. ||||    |. ||.... |..  .|||...  |||.|.| |.| |. .|.
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkl
0045098 (Phosphotyrosine protein) phosphatases II 1144-1413 9.9e-60 197.6 In-house 5-274 (278) alignment 
Range on Protein: 1144-1413
Range on HMM: 5-274/278.0
VGGKTRLEKQFKLVTQCNakyVECFSAQKECNKEKNRNSSVVPSERARVGlaplpgmkgtDYINASYIMGYyrSNEFIITQHPLPHTTKDFWRMIWDHNA
  ....|| .|.|.. ..    |.. |....|..||| ....| .. ||           ||||||||.||  ...||.||.|||.|. |||||.|... 
asldlllefefllllgip...seitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgi

QIIVMLPDNQSL-AEDEFVYWPSrEESMNCEAFTVTLISKDRLclsneEQIIIHDFILEAT----QDDYVLEVRHFQCPKWPNPDAPISS----TFELIN
..|||| . . |  |  . |||. ..|.... |||||.| ..|     . ......... .    .|.. ..|.|.... ||  ..| ..     .||..
tvivmltelvelgrekcaqywpe.ggsltygdftvtllseevl.....ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflelle

VIKEEALT-------------RDGPTIVHDEYGAVSAGMLCALTTLSQQLenENAVDVFQVAKMINLMRPG-VFTDIEQYQFIYKAMLSLVST
 |.|   .             ..||..||  .|   .|.|.|. .. ..|  |. ||.... |..  .||| ...  |||.|.|...| |.. 
firealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllr
subfamily_PTPN23_pd Subfamily PTPN23 1144-1414 1.7e-39 130.3 In-house 11-283 (288) alignment 
Range on Protein: 1144-1414
Range on HMM: 11-283/288.0
VGGKTRLEKQFKLVTQCNAKYVECFS-AQKECNKEKNRNSSVVPSERARVGLAplpgMKGTDYINASYIMGYY-RSNEFIITQHPLPHTTKDFWRMIWDH
..||| |.|.||...| ..|  . .| |  ... ||||.  ..| ...|| |      .  ||||||.. .    . .||.|| ||. |  |||.|... 
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeq

NAQIIVMLPDNQSLAED-EFVYWPSRE-ESMNCEAFTVTLISKDRLclsneEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVIK
 ...|||| ... | .     |||... |... ....||| |. ..     |. . ....||  . | | .|.| |  .||.  .|   .. ........
kssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvret.....ethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeve

E--EALTR--DGPTIVHDEYGAVSAGMLCALTTLSQQLENENA-VDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTK
.  ||  |  . | .||   |   .|... . .  ..||..|  .|. || . .   |  .  . ||..| |.|.|  .   
sayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrv
0050432 (Phosphotyrosine protein) phosphatases II 1145-1414 2.3e-71 236.0 In-house 39-302 (308) alignment 
Range on Protein: 1145-1414
Range on HMM: 39-302/308.0
GGKTRLEKQFKLVTQCNAkYVECFSAQKECNKEKNRNSSVVPSERARVGLaplpGmKGTDYINASYIMGY--YRSNEFIITQHPLPHTTKDFWRMIWDHN
 ....||..|. ....   . |...|....||.||| ....| .. || |    . .|.|||||||..||  .....||.||.|||.|..|||||.|..|
ldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....d.egsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvweqn

AQIIVMLPDNQSLA-EDEFVYWPSR--EESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIK
 ..|||| . .    |  . |||.   ..|.... |||||.| .      .. ...  ..|. ..|.....|.||... ||. ..|  ... ..... ..
vrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.....lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvr

EEAltRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTK
.    ..||..||   |   .| ..|| .| .||| |. ||||.. |..  .|||.... |||.|.|.|.| ....|
ksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1145-1413 3.2e-46 152.7 In-house 18-281 (288) alignment 
Range on Protein: 1145-1413
Range on HMM: 18-281/288.0
GGKTRLEKQFKLVTQCNAKYVECFSaQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQ
 ..| ...... ... . .  .. . ..  |..|||   ..| .  || |  |.  .|.|||||||| |. .....| || ||..| .|||.........
rnrtgfseeynsLaalektksvtag.rlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenkts

IIVMLPDN-QSLAEDEFVYWPSREESMNCEAFTVTLISKDrlclsNEEQIIIHDFILEatQDDYVLEVRHFQCPKWPNPDAPISST--FELINVIKEEAL
 |||| .  .   .    |||. ..  |   .||||...      ..|... . ..||  ..   ||. ..|   ||. . | |..  .||.. .|    
tivmltelveggktkCeeYWPdadkpknyGsvtvtlvesk.....eledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanq

TRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
   || |||   |   .|   || .| ...|.|. .||. . . .   |. .    .||.|||...|||.. 
adtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsliee
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1145-1413 5.1e-44 145.3 In-house 17-285 (290) alignment 
Range on Protein: 1145-1413
Range on HMM: 17-285/290.0
GGKTRLEKQFKLVTQcNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKG--TDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHN
 |... ..||| . .  ..  .   .  . ||..|| . .|...  |. | |..| |    .||||.|| ||  ....|.|| |...| .|||..||...
kgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqek

AQIIVMLPDNQSLAE-DEFVYWPSREESMnCEAFTVTLISKDRLclsNeeQIIIHDFILEATQ-DDYVLEVRHFQCPKWPNPD---APISSTFELINVIK
  ||||| . ..  .     |||... ..  . |...|..   |   |  ..|.  . .. .. ...  .| ..|   |.. .   .| ...  . ...|
vtiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetl...n..eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

EEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
 .  . ... .||   .   ....||..|  .. . |  .||||| |     .||  .  .|||.|.. .|. ...
tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_PTPRG_pd Subfamily PTPRG 1146-1416 2.7e-114 377.4 In-house 17-292 (563) alignment 
Range on Protein: 1146-1416
Range on HMM: 17-292/563.0
GKTRLEKQFK-LVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGT-DYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNA
|.......|. |......|.... ..||..||.|||....|...|.|| |.||||.|.. |||||.||.||..|..||.||.||..|..|||||||..|.
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

QIIVMLPD-NQSLAEDEFVYWPSrEESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQD-DYVLEVRHFQCPKWPNPDAPISSTFELINVIKEEAL
.||||... ... .....||||. .||....|..||||....|.|.......|....|..... |....||.....|||....| .|...||.|.|..| 
aiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

TRD--GPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKEN
...  ||..||...|....|....|.||..|...||||.||...|.|...|. .....|||.|...|.|.....||.
nkaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasket
subfamily_PTPRD_pd Subfamily PTPRD 1146-1413 4.1e-66 218.8 In-house 21-283 (564) alignment 
Range on Protein: 1146-1413
Range on HMM: 21-283/564.0
GKTRLEKQFKLVTQCnaKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQI
.....|...| ...   . ... .|.|..||.||| . .|. .. || | ...| .|.||||||.| || .....| ||.||..|..|||||.|..| ..
sdlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsst

IVMLPDNQSLAEDEF-VYWPSREeSMNCEAFTVTLISKDRLclsneEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVIKEEALT
||||   .   ....  |||... . ... .|||| .. .|     ....| .|.|. .... . |||.|.  .||. ..| | |   .||. ... . .
iVmltkleEkgkvkchkYWPekg.tetygeltVtleeeeel.....adyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnep

RDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
  ||..||   |    |. ...  . .....|. ||..|. |..   |. .    |||.||..|.|  .. 
dagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1146-1413 3.9e-57 188.7 In-house 18-282 (318) alignment 
Range on Protein: 1146-1413
Range on HMM: 18-282/318.0
GKTRLEKQFKLVTQCNAKYVECFSaQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQI
|.. |..... .......  .  |  ...|| |||   ... ...|| | .| | .|.|||||.|| || |....| .| |||.| .|||||.|. |...
Gelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

IVMLPDNQSLAEDEF-VYWPSReESMNCEAFTVTLISKDRLclsneEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISStFELINVIKEEALTR-
|||| . .  . .    ||||. .|.. .. .|.| .. .|     .. ..  | .. |. . . .|| ... .||. . | |.  .|......   .  
ivmltqeeergkakvhryWPsk.gsrsygklvvelkeevel.....sdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg.aslldlvrqvskaqq

---DGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
    ||..||   |   .|. .|. .| .....|. |||||. |..   |. .    .||.|||...|  . .
ksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_PTPRB_pd Subfamily PTPRB 1146-1416 6.1e-49 161.6 In-house 23-290 (293) alignment 
Range on Protein: 1146-1416
Range on HMM: 23-290/293.0
GKTRLEKQFKLVTQCNAKyVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQI
 ..|. .... . . . .  .. .|....|..||| . ..| . .|| ||.| . .|.|||||.|| ||   .||| || |||.|..|||||.|.....|
sdlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssi

IVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTLISKDrlclsNEEQIIIHDFILEAtqDDYVLEVRHFQCPKWPNPDAPISS--TFELINVIKEEA--
|||| .           |||. ||...    .|||....     . |. .|... .|   ..   .||...   ||. . | ..    .... ..|..  
ivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaee.....eledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvreaiek

LTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKEN
 ....|..||   |   .| . || .| |..|.|. ||.| .   .   |  .    .|| ||....|.|...||.
taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkee
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1146-1413 6.4e-42 138.5 In-house 18-280 (287) alignment 
Range on Protein: 1146-1413
Range on HMM: 18-280/287.0
GKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAplpgMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQI
|..  ..||... | . .  |   .  . ||.||| . ... .  || |      .  |||||..| ||  ...|||.. |. .| ..||..|.|.| ..
gnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvta

IVMLPD-NQSLAEDEFVYWPSREEsMNCEAFTVTLISKDRLCLSNEEQIIIHdfilEATQDDYVLEVRHFQCPKWPNPD---APISSTFELINVIKEEAL
|||| . ...  |  . |||. .  .    ....|.....     | .. ..    . ....  ..|. .|  .|..      | .. . . . .|..  
ivmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevk....nknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrk

TRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
  ... .||   .   ..|.||  |  .. ..| ..||||| |     .||    .|||.||....|  ...
rgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_PTPN6_pd Subfamily PTPN6 1146-1415 4.1e-39 129.4 In-house 24-301 (306) alignment 
Range on Protein: 1146-1415
Range on HMM: 24-301/306.0
GKTRLEKQFK-LVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLApLPGMKGTDYINASYIMGYYR--SNEFIITQHPLPHTTKDFWRMIWDHN
.|. .|..|. | .. . |...   ..|  ||||||  ...| . .|| |.  |...|.|||||.||..  .  ....| ||  |..| .|||||.|. |
ekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqen

AQIIVMLPDNQSLAEDE-FVYWPSREESMNCEAFTVTLISKDrlclsNEEQIIIHDFILE-ATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVIKE
...|||.  .   ...    |||. ||. .    .|| .|..     . .. |. .. ..  ....   ||....  .||. . | .     .... ...
srvivmttkevErgkekCarYWPdeeekeeyGkisvtnvsek.....sladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnr

EALT----RDGPTIVHDEYGAVSAGMLCALTTLSQQLEN---ENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKE
.. .    . ||..||   |    | .  . .| ...|.   .  .|. .. |..   | |.    .||.|.|||.   . ||.
kqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkk
subfamily_PTPRN_pd Subfamily PTPRN 1146-1409 1.5e-30 100.9 In-house 27-290 (297) alignment 
Range on Protein: 1146-1409
Range on HMM: 27-290/297.0
GKTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGY-YRSNEFIITQHPLPHTTKDFWRMIWDHNAQ
 |.||||... ... .|.   .  |..| | .|||...|.| . .|| |      . .|||||| |.    |.  .| || ||..|  |||.|.|.. . 
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

IIVMLPDNQSLA-EDEFVYWPSREESMnCEAFTVTLISKDRLClsneEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISS--TFELINVIKEEAL
.||.|   .    . .  |||   ...  ... | |.|.   |    .. ..  | |   | .    |  |    ||. ..| |.   .|.   .     
vivnltrleeegvkqckrywpdeGsev.yhiyevhlvsehiwc....ddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr

TRDGPTIVHDEYGAVSAGMLCALTTLSQQLEN-ENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
 |  | .||   ||  .|. ...  . ..| .  . .|.    . .   |||.    .|..|...|.  
GrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
0040438 (Phosphotyrosine protein) phosphatases II 1147-1414 6.9e-69 227.9 In-house 17-279 (317) alignment 
Range on Protein: 1147-1414
Range on HMM: 17-279/317.0
KTRLEKQFKLVTQCNAKyvECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQII
.|.|...|. . ...    ..  |....||.|||.....| .. || | ||.|  ..|||||||. |......||.||.|||.|. |||||.|... ..|
ftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvi

VMLPDNQSL-AEDEFVYWPSrEESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEALTR
||| .   |  |  . |||. .|..... |||||.| .      .. |... . .| ..|.....|.||... ||  ..|  ... ..... ..|    .
vmLteleelgrekcaqYwpl.getltygdftvtllseee.....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedp

DGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTK
.||..||   |   .|...|. .. .||| |. |||... |... .|||...  |||.|.|.|.| .. .|
ggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1147-1409 3.3e-44 146.5 In-house 33-289 (319) alignment 
Range on Protein: 1147-1409
Range on HMM: 33-289/319.0
KTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQII
.|.|| .|. ...  ..  .   |  . ||.|||   ... ....| | .| |. ..||||||.. || | . .| .| ||. | .|||||||..|.  |
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VMLPdnqslAEDEFVYWPSREeSMNCEAFTVTLISkdrLCLSNEeqIIIHDFILEA-TQDDYVLEVRHFQCPKWPNPDAPISsTFELINVIKE-EAL---
|.|       .    ||| .   .. | | | . |   .  ..|   .. |. |   ..   . ... |    ||.   | . . .|. ..|  . |   
vllt.....kdkcsqywplki.vikeerfkvkvds...veetae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdy.psdlmrlvkkvrhltsk

-TRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
     . .||   |.  .|.  .| .| .....|. |||... . .   |. .  |. ||.||| |.| 
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1147-1407 4.2e-26 86.5 In-house 5-255 (267) alignment 
Range on Protein: 1147-1407
Range on HMM: 5-255/267.0
KTRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAplpgMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQII
.. .||.|.|...   .   .     | |.|.||   ..| . .|| |      |  .||||||. ||.. | ||.|| ||  |  ||. .| |..  .|
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilr....tkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMLpdNQSLAEDEFVYWPSR-EESMNCEAFTVTLiSKDRlcLSNEEQIIIHDFILEatqDDYVLEVRHFQCPKWPNPDAPISSTFELINVIKEEALTRD-
|.|   ..  ..   .|| .  .. . . .||   | ..    |. |||  .. ..   ..   .|  .   ||            |. .. .. |    
vll..tkvftdnirlfwPPkmgqakkyqdltveh.slek..eendyqiitlelkfk...nesahnvtlyyykkwnintnnkpylkplfgilaknqlengn

GPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAM
 | .|. . |   .| .  . .  ... .|. .|.|.  . |   |.|.    |.| .|.. .
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihell
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1147-1410 2.9e-20 67.5 In-house 15-276 (307) alignment 
Range on Protein: 1147-1410
Range on HMM: 15-276/307.0
KTRLEKQFKLVTQCNAK--YVECFSAqkecNKEKNRNSSVVPSERARVGLApLPGMkGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQ
 ..|  .|. ... . .   ||.|||    | .||| . |   ...|. .  ..|.  .||| | |.    . . || .| ||  |  .|| |. ... .
vqalvdefrvlakktpegvtveafsa....ntdknryqdvkcqdkgrivvk.fdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekve

IIVMLPDNQSLAEDE-FVYWPSREESMNC---EAFTVTLISKDRLCLSNEEQIIiHDFILEATQDDYVLEVRHFQCPKWPNPDAPISsTFELINVIKEEA
 ..|| .   ||.     |||  |   .    .. |...       |. .|..|     |.    .    ..|.|  .||.  .|    .  ||...   
svimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedli.nvttlkvdwaqksrtiqhlqwenwpdrgvpqi.nltainlleavr

lTRDGPTIVHDEYGAVSAGMLCALTTLSQQ-LENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
     | .||   |   .| . |.. . .. .. .|  |. .. . .   |.    .  || .... .|. 
.ydtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1148-1413 1.9e-52 173.3 In-house 27-292 (298) alignment 
Range on Protein: 1148-1413
Range on HMM: 27-292/298.0
TRLEKQFKLVTQCNA--KYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQI
|.....|. ... .   .  |   |.|. ||.||| ....... .|| |    . . .||||||.. .| ..| ||.||.||..|..|||||....... 
tgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedigt

IVMLPDNQSLAE-DEFVYWPSREeSMNCEAFTVTLISKDrlclsNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVIKEeALT
|||| . . | . .   |||... . . . .||.| ||.     .  ..|.  .... .. .   |||...  .||. ..|   .| ..|.. ..    .
iVmltnleeldktkyhkywPdeg.ketygeitvsllske.....efadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqq

RDG--PTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
. |  | ||.   |   .|  .|. .. .....|. |||||| |..   |||. .  ||| |||.|.|  ...
qagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1148-1414 1.2e-45 151.0 In-house 22-286 (305) alignment 
Range on Protein: 1148-1414
Range on HMM: 22-286/305.0
TRLEKQFKLVTQCnAKyvECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIV
. ||.|.|....   .   ..  .|| ||.|||...... .  |. |.. . .. .|||||||. || |....|..| ||..| .||||.|..   . ||
kgleaqykslyee.ee..sidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstiv

MLPDNQSLAEDE-FVYWPSREES-MNCEAFTVTLISKDRLclsneEQIIIHDFILEA-TQDDYVLEVRHFQCPKWPNPDAPIS--STFELINVIKEEALT
|| . .   .|    ||| ..   .. . |.|.| |.        .. |. .. .    .|.    | ..|  .||.   | .  |  .||. ....   
mltklveggkdkCrqYWpesktekkefgefsvelksekta.....sdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrvqkdqkk

RDG-PTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTK
  | | .||   |   .|. .|.    ..|..|. ||||.| | .   |... .  .||.|.. |.  |. . 
dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1148-1413 2.3e-36 120.0 In-house 15-295 (301) alignment 
Range on Protein: 1148-1413
Range on HMM: 15-295/301.0
TRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIV
...|.|.| ... . |  .    ... . ....| .|.. .|  .   |   .. ..||||||| || ....||..| |. .| .||||.||..  . ||
nkfeeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpvsiv

MLPDNQSL-AEDEFVYWPS-REESMNCEAFTVTLISKD--------RLC--LS--NEEQIIIHDFILEATQddYVLEVRHFQCPKWPNPDA---PISSTF
|. . .    .  . |||. ..|| .   |||||...         .|.  .    ... |.. |  ....     .|  .|  .||.      |     
mvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprtvLq

ELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
 . .||. .     || .||   .   .|. |...    |   |  |||||| | .   .||. | .||| .||...   .. 
viddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1148-1414 5.8e-14 46.2 In-house 26-288 (302) alignment 
Range on Protein: 1148-1414
Range on HMM: 26-288/302.0
TRLEKQFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGlaplpgMKGTDYINASYIMGYYRSNEFIITQHPLPHTT---KDFWRMIWDHNAQ
....|.|| . .  ..  .| . .|. .| .. .  .. |.. ...      ..  .|.||| .     ... |..| |   ..    .||||..... .
aevkkefkkidtmkvdlekCkafkknlkknqsedvpildsnlvkle......aepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekiv

IIVMLPDNQSLAE--DEfvYWPSREESMncEAFTVTLISKDRlCLSNEEQIiiHDFILEATQDD----YVLEVRHfqCPKWPNPDAPISSTFELINVIK-
 .|.|  .. | .  .|  ..| . ..   . .    . . .   . ||.   . ...|   ..     . .| .  .  |..   |.. .    .. | 
svvilvgeeelkktlse..lfpkksgdy..keygkmfvNnrk.Vekaeeek..tryviEvlPegcsnsvlanvyv..ltnWkqkkvpvkyaeliktaakv

-EEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTK
 ..    | .|..  ..||  ||.. .|..  ..|...... . ...| |   || .   ..|| ..| |.| .. .|
fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk
0046845 (Phosphotyrosine protein) phosphatases II 1150-1414 6.4e-69 227.8 In-house 2-277 (284) alignment 
Range on Protein: 1150-1414
Range on HMM: 2-277/284.0
LEKQFKLVTQCNAKYV-ECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGM-KGTDYINASYIMGY-----YRSNEFIITQHPLPHTTKDFWRMIWDHN
||..|. ..... |.. ..  |....|..||| ....| .. || | .|.|  ...|||||||. ||     |....||.||.|||.|..|||||.|..|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

AQIIVMLPDNQSLA-EDEFVYWPSREESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEATQ-DDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKE
...|||| .  .   |  . |||. .|..... |||||.|..      .. .... . |. .. ......|.||....||. ..|  ... .|... ..|
vrvIVmltelvengrekcaqYwplegevltygdftvtllseev.....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvre

EAL--TRDGPTIVHDEYGAVSAGMLCALTTLSQQLENEN---AVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTK
      ..||..||.  |   .|...|| .| .|||.|.    |||... |..  .||| ..  |||.|.|.|.| ....|
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
DSPc_SM00195 1150-1411 4.5e-65 214.9 In-house 2-262 (263) alignment 
Range on Protein: 1150-1411
Range on HMM: 2-262/263.0
LEKQFKLVTQCNAKYvECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVML
|...|. . . . .  |. .|.|. ||.||| . ..| .. || | . .. .|.|||||.|| |. .....|.||.|||.| .|||||.|... .|||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

PDNQSL-AEDEFVYWPSR-EESMNCEAFTVTLISKDRLClsneEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEALTRDG
 ...    |    |||.  ..... . ..|.|....       ..||.... |......   .|...|. .||. ..|   .|..||....|..  | .|
teeeengkekcdrywpeesggketfgkisvklvevekkk....deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssg

PTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV
|..||   |   .|..... .. ..||.|. ||.|.. |..   |||...  |||.|||.|.| ..
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1150-1411 4.5e-65 214.9 In-house 2-262 (263) alignment 
Range on Protein: 1150-1411
Range on HMM: 2-262/263.0
LEKQFKLVTQCNAKYvECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVML
|...|. . . . .  |. .|.|. ||.||| . ..| .. || | . .. .|.|||||.|| |. .....|.||.|||.| .|||||.|... .|||||
lkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivml

PDNQSL-AEDEFVYWPSR-EESMNCEAFTVTLISKDRLClsneEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEALTRDG
 ...    |    |||.  ..... . ..|.|....       ..||.... |......   .|...|. .||. ..|   .|..||....|..  | .|
teeeengkekcdrywpeesggketfgkisvklvevekkk....deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssg

PTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV
|..||   |   .|..... .. ..||.|. ||.|.. |..   |||...  |||.|||.|.| ..
pivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN12_pd Subfamily PTPN12 1150-1413 4.8e-44 145.4 In-house 10-279 (290) alignment 
Range on Protein: 1150-1413
Range on HMM: 10-279/290.0
LEKQFKLVTQCNAKYV-----ECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQ
..|.|. . ....||      .  ...|| |..|||   ..| . .|| |    . .| |||||..| | . . |.| .| |||.| .|||||||..| .
fakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknve

IIVMLPDNQSLAEDEF-VYWPSR-EESMNCEAFTVTLISKDRLclsnEEQIIIHDfiLEATQDDYVLEVRHFQCPKWPNPDAPISS--TFELINVIKEEA
|.||.  .  |.      |||.. ||... ..|.|||......    .....|    |......   .|. |.  .||. . | |    .|||. ..|  
ivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekav....dddflirt..LkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrelq

LTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENA---VDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
 . | | .||   |   .| ..|.    ..|..|.    .|||..   .   |. .    |||...|||...||..
esedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqk
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1150-1410 5.7e-22 72.7 In-house 29-289 (310) alignment 
Range on Protein: 1150-1410
Range on HMM: 29-289/310.0
LEKQFKLV-TQCNAkyVECFSAQKEcNKEKNRNSSVVPSERARVGLApLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVM
| ||.. . .. ..     . | |. .  ||| | ||  . .|| |  .   .  ||| | |.   |  . || .| || ||  ||||||..  |. |..
lvkqyrkldakqds..sltyeaykk.ymhknrysdvvcldtsrvklk.idksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesill

LPDNQSLAEDE-FVYWPSR--EESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVR--HFQCPKWPNPDAPISSTFELINviKEEALTR
|             ||||    |.  |   |    | . . . |    .. | .    |   . |.|    . |.||.   |      . .  .  |  |
lckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq..rllaqvr

DGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
 || .||   |    ....||    ..|.. . ||. .|   .   |  .     || .| . .. .
hgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvriif
subfamily_Ptp69D_pd Subfamily Ptp69D 1151-1412 1.1e-49 164.2 In-house 25-287 (307) alignment 
Range on Protein: 1151-1412
Range on HMM: 25-287/307.0
EKQFKLVTQCnAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLP
.| .. . .      ..  ..|. |. |||   ... .. || |....| . .||||||.| ||  ...||. | |.  | .||||||.. . ..|||| 
akeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivmls

DNQSLAED-EFVYWPSReESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISS--TFELINVIKEEALTRDGPT
. .   ..    |||   . .. .   |.|.|...     . .. .     |... .   .|  ..   |..  .| ..   ..||. ..|   .  .| 
nlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrsPi

IVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVS
.||   |.  .|.. ||. | |||..|. ||.|.. | .   |. ... .|||.|.|.|.|   |
vvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss
subfamily_ptpA1_pd Subfamily ptpA1 1151-1266 4.4e-21 70.1 In-house 24-138 (418) alignment 
Range on Protein: 1151-1266
Range on HMM: 24-138/418.0
EKQFKLVTQCNAkYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRsNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLP
...|.|. .      |    .|. |  ||| . ..| ...|| |  .   .|.||||| || | |  ..|| || ||| |  |||||.|.  ..||||| 
keefrlleesvg.psetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivmls

DNQSLA-EDEFVYWPSR
 .   .      ||| .
resencrikcdrywpeq
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1153-1409 3e-38 126.3 In-house 11-264 (283) alignment 
Range on Protein: 1153-1409
Range on HMM: 11-264/283.0
QFKLVTQCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGmkgtDYINASYIM---GYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVML
... . . .    ..  |  . ||.||||  .|| .. || | ...     |||||..|.    | .....||.| || .| .|||.|..|...  ||||
frevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivml

PDNQS-LAEDEFVYWPSReESMNCEAFTVTLISKdrlclSNEEQIIIHDFILEAT--QDDYVLeVRHFQCPKWP--NPDAPISSTFELINVIKEEALTRD
   |  | .    |||.|  |..   |||||          ..  ||. ..|       . .| . |.|   |   ...|.| |   .  ||      ..
tklqedlrikCsqyWPkr.GsedyGeftvtlrke.....ttsnsfiikelllrvnssakstll.lahyqvidWleygeqaiinslvkfnkvislqteskk

GPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
|| .||   |   .....|...  ...  |  ||||.| |..   |...    .||.......| 
gPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_PTPN13_pd Subfamily PTPN13 1153-1412 9.5e-38 125.0 In-house 16-270 (273) alignment 
Range on Protein: 1153-1412
Range on HMM: 16-270/273.0
QFKLVTQCNAKyVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGmkgtdYINASYIMGYYRSNEF--IITQHPLPHTTKDFWRMIWDHNAQIIVMLP
.|| . .  ..  .| ...|. ||.|||   |.| ...|| |    |     |||||.|      .|.  |..| |||.|.||||.|.|. .|..|.|. 
efkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvt

DNQSLAE-DEFVYWPSREESM--NCEAFTVTLISkdrlcLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPiSSTFELINVIKEEALTRD--G
 ..   .     |||.....     . ..|.|.      . . ..  .... .. ..   . || |..  |||. . | ||. ||.....| .  ..  |
lekekgkvkchrywPesknkklkvsnrlevellk.....vqkldgfvvralavkdsesgesrevahlnfvkwPdhgvP.ssaaellqfvaevrrlqtdag

PTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVS
| .||   |   .|.| .. .. . .|... .|| .. . .   | ||    .|| |.|||.| ...
PivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_CG7180_pd Subfamily CG7180 1155-1412 4.1e-46 152.0 In-house 20-291 (296) alignment 
Range on Protein: 1155-1412
Range on HMM: 20-291/296.0
KLVTQCN--AKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDN
||. .     .  .|  . .. |.||||.  ||| . .|| |  | | . .|||||.|. .. . .|.|.|. |  .| ..|||...|.... .|.| ..
klelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtkt

QSLAEDEFVYWPSREeSMNCEAFTVTLISKDRLCLSNEEQIIIHDFILE--ATQDDYVLEV---RHFQCPKWPN-PDAPIS--STFELINVIKEE---A-
 . |.    ||| .    .   . | ..... .   .  .. .   |.   ... . . |.   ..||  .|.     |.|  .  ||.. ..     . 
fdfakmypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvd

-LTRDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVS
     ||..|. . ||  .|. .|.    ...|.|. ||||. .|..   ||..   .|.|..||  .|  | 
edpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1155-1410 3.9e-32 106.2 In-house 27-278 (439) alignment 
Range on Protein: 1155-1410
Range on HMM: 27-278/439.0
KLVTQCNAKYV-ECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDnq
. .   . .|  ..  | .| .. |||  .|.. . .|| |  .||.  . |||| || |||  . .| || |  .||.||||.......  |||| .  
ekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivmltn..

slAEDEFVYWPSREESMNCEaftvTLISKDRLCLSNEeqIIIHDFIL--EATQDDYVLEVRHFQCPKWPNPDAPIS--STFELINVIKEEA-LTRDGPTI
    . . |||| .| .  .      .  ||     .   .|. | .  |  . .    | .|.   ||. . |       ...  |.        || .
..lvesykywpsdaevcygd....iavrvdrnielpn..yvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvv

VHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
||   |   .| . ||    .||  || ||.  . |..   |  .  .. || |||.|.|  
vhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavled
subfamily_PTPN1_pd Subfamily PTPN1 1159-1409 4.7e-31 102.6 In-house 16-269 (290) alignment 
Range on Protein: 1159-1409
Range on HMM: 16-269/290.0
QCNAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAplpgMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLpdNQSLAE-
. .|. ... .|... |...||   | | . .|. |      . .|||||| .       ..|.|| |||.|.. ||.|.|..... .|||  |. . . 
rkeasdfptreaklpenrnlnryrdvspydhsrikle....radndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvml..nkvveke

--DEFVYWPSREE--SMNCE--AFTVTLISKDRlclsnEEQIIIHDFILEATQDDYVLEVRHFQCPKWPN---PDAPISSTFELINVIKEEALTRD-GPT
    . |||. ||  .. .|   ..|.|||..|     ... ... . ||  . .   |. ||   .||.   |..| .    | .| .  .|..| ||.
qikcaqywPqgeeekellledtklkvkliseer.....ksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpa

IVHDEYGAVSAGMLCALTTLSQQLENE---NAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
..|   |   .| .| . |.  ..|..   ..||. .|   .  .| |.    .| .| | |.| 
vihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1161-1414 5.1e-38 125.9 In-house 37-287 (297) alignment 
Range on Protein: 1161-1414
Range on HMM: 37-287/297.0
NAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRsnEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEF
.|.  .   |.|  | ||.| . ..|... || || .      ||.|||.. |.    ..| || | . | .|||.|..|.....|||| |..   .   
eaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkca

VYWPSREeSMNCEAFTVTLISKDRLclsneEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPI----SSTFELINVIKEEALTR-DGPTIVHDEYGA
 ||. .  ...    .|.| | ..      |  |  .. ..  .      |. .|  .||. . .     ||  .||. ....  .. .|| .||   | 
ryWsdkg.vttfGdvsvvllsvser.....eGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvhclaGv

VSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTK
  .|.|...     . ..|..||.|.. |..   || .    |||.|.|.|.|  ....
Grtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallse
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1161-1410 6.5e-18 59.4 In-house 42-282 (290) alignment 
Range on Protein: 1161-1410
Range on HMM: 42-282/290.0
NAKYVECFSAQKECNKEKNRNSSVVPSERARVGLAplPGMKGtDYINASYIMGYyrSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAED-E
 ..|.|    .|. . .|||   ||  ...|| |    | .| ||. | |. |      ||.|| .|  |. |.|||. ....  |||| .         
pvqylerkifdkntefkknrykdvvcndktrvilk..dGydG.dyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakc

FVYWPSRE-ESMNCEAFTVTLISKDrlclSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPIsSTFELINVIKEeALTRDGPTIVHDEYGAVSA
  |.| .| | .   ..||.   .|    .....|| . . .   ..     ..|..   ||.   .  ||. |. ...    .  || .||   |   .
eqyypekeGevltfGeitvlcseed....dkdaniikktlsvrdkdsGkehklkhlkikswpdksval.stlallrtlri.lrkasGpvvvhcsaGiGrt

GMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
| . |. .  | | .  ..|. .. . .   | .      ||  . ...| |
GtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1162-1409 5.1e-43 142.6 In-house 12-253 (284) alignment 
Range on Protein: 1162-1409
Range on HMM: 12-253/284.0
AKYVECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPdnqslAEDEFV
..  .   |  . ||.|||   ... ....| | .| |. ..||||||.| || | . .| || ||. | .|||||||..|.  ||.|       .    
vngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt.....kdkcsq

YWPSREeSMNCEAFTVTLISkdrLCLSNEeqIIIHDFILEA-TQDDYVLEVRHFQCPKWPNPDAPISsTFELINVIKE-EAL----TRDGPTIVHDEYGA
||| .   .. | | | . |   .  |.|   .. |. |   ..   . ..| |    ||.   | . . .|. ..|  . |        . .||   |.
ywplki.vikeerfkvkvds...veesee..yvvrdielsedgkekdirkirqfhflgwpdvgvpdy.psdlmrlvkkvrhltskenhranivvhcsagv

VSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
  .|.  .| .| .....|. |||... . .   |. .  |. ||.||| |.| 
grtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN3_pd Subfamily PTPN3 1164-1410 1.3e-34 114.4 In-house 30-274 (280) alignment 
Range on Protein: 1164-1410
Range on HMM: 30-274/280.0
YVECFSAQKECNKEKNRNSSVVPSERARVGLAplpgMKGTDYINASYIM----GYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAED-
 ...  |.|  | .|||   ..| . .|| |        ||||||.|.     .   .| .|.|| ||..|..|||.|.|......|||| ..       
glaisaarkpenlsknryrdilpydatrvklk....esetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvk

EFVYWPSREESMNCEAFTVTLISKdrlclSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVIKEEALTRDGPTIVHDEYGAV
   |||. |....   |.|.. ..     ........ ...|. .. .   .. ..|   ||. . | .|.  .|... ...   ... |..||   |  
ChqyWPetedeleygefsvkceke.....detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGig

SAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
 .|.| .| |  . .|....| . .. ...   |  .    .||.|. .|.| .
rtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_PTPRA_pd Subfamily PTPRA 1165-1409 1.3e-47 157.3 In-house 48-293 (330) alignment 
Range on Protein: 1165-1409
Range on HMM: 48-293/330.0
VECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYW
  .  |.|| ||||||   ..| . .|| |... |.. .||||||.| || . ..|| .| |. .| .|||||||..... |||| . .   |.    ||
atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqyw

PSrEESMNCEAFTVTLISKdRLClsneEQIIIHDFILE----ATQDDYVLEVRHFQCPKWPNPDAPISS--TFELINVIKEEALTRDGPTIVHDEYGAVS
|. | ..     .|..  .  ..    ... . .|...    ||... .  || |    ||.   |. .   ..|.. .|.      || .||   |.  
Pd.eGlvtyGnirvevede.tvl....vdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGr

AGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
.| ...| .. .... |. ||||.. | . | || .    |||.||||..| 
tGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
subfamily_PTPN14_pd Subfamily PTPN14 1165-1410 6.3e-30 99.2 In-house 39-295 (300) alignment 
Range on Protein: 1165-1410
Range on HMM: 39-295/300.0
VECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMkGTDYINASYIMGYYRS--NEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDN-QSLAEDEFV
 .. .|. . |.||||   |.| | .|| |.|      |.||||| |     .   ..|..| ||..| .|||.|.|... |.|||| .. ..  |  | 
allstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksfk

YWPSREESMNCEAFTVTLISKDrlCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPIS-----STFELINVIKEEAL------TRDGPTIVH
|.|. |.. .   |    ...     .. ...| . . |.        .| |.|   ||. . |       |  | .. .....        .. | .||
yfPkleskkktvefgkfkvttk..fsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPPvlvh

DEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
   |.  .|.|     | . ||... .|. .| ...   |  .   . ||.|.||...  
CsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvliky
0040439 (Phosphotyrosine protein) phosphatases II 1166-1411 2.3e-61 202.9 In-house 2-246 (249) alignment 
Range on Protein: 1166-1411
Range on HMM: 2-246/249.0
ECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSL-AEDEFVYWP
|.  |....||.|||.....| .. || | .|||. ..|||||||| |||....||.||.|||.|..|||||.|... ..|||| . . |  |. . |||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

SrEESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKE--EALTRDGPTIVHDEYGAVSAGM
. ..|.... |||||.| .      .. ...  . |. ..|. ...|.|.|...||  ..|  .......|. ...  |.| ..||..||   |   .|.
l.ggsleygdftvtllsvev.....kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGt

LCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV
..|. .. .||| |. ||.... |... .|||...  |||.|.|.|.| |.
fiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
subfamily_PTPN9_pd Subfamily PTPN9 1166-1411 3.1e-37 123.2 In-house 33-290 (297) alignment 
Range on Protein: 1166-1411
Range on HMM: 33-290/297.0
ECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWP
.   ... .| |||| . |.  ...|| || ... . .|||||... || . . || || ||..|..|||||.|.... .|||              |||
tflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWp

SREESmnCEAFTVtlISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISS--TFELINVIKEE-------------ALTRDGPTIV
. |||  .. |.   .|  ..   .||.  .. . .. ....   .| |||   ||.   | |.   ........|.               ... | .|
leees..saefgd..lsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqalavkelgdewkghpsgPPivv

HDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV
|   |   .| ...|    ..||... |||... |..   |       |||.| |.|.|   
hcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1166-1325 1.9e-16 54.8 In-house 23-180 (297) alignment 
Range on Protein: 1166-1325
Range on HMM: 23-180/297.0
ECFSAQKE-CNKEKNRNSSVVPSERARVGLapLPGMKGTDYINASYIMGYYRS--NEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FV
| ||. |      |||   ..  . .|| |  | .. ..||||| |..         .|..| ||  | .|||....... ..|||.   |    |  . 
esfssakrnsslrknryrdilatddtrvkl..lrviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcap

YWPSR-EESMNCEAFTVTLISKDRlclSNEEQIIIHDFILEATqdDYVLEVRHFQCPKWPNPDAP
||||  .| ...  . |  .|.      . ...|. .. |     .    ||| |   ||.   |
ywpsvvqerlkagdvvveflssts...defdrviltelqliyr..sesrvvrhvqflswpdhGvp
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1166-1408 1e-12 42.6 In-house 26-267 (285) alignment 
Range on Protein: 1166-1408
Range on HMM: 26-267/285.0
ECFSAQKECNKEKNRNSSVVPSERARVGLAplpgMKGTDYINASYI-MGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDN-QSLAEDEFVYW
.|  .  |.| . || . |   | .|| |      .  ||| ||.. |     . .| || ||| |  |||.||.. .   ..||    .   |   .|.
nctytayeanpdlnryadvrcieetrvvlk....nhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyy

PSR-EESMNCEAFTVTLISKDRLCLSNeeqIIIHDFILEATQDD--YVLEVRHFQCPKWPNPDAPISS--TFELINVIKEeALTRDGPTIVHDEYGAVSA
| .  | ..   . .||      ...     |.  . .  |.|     | . | | | ||.  ||  .    || . .|.    .. |  ||   |   .
peklgevvkfgkyeitlteckeeaiag...tilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrt

GMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAML
  .  .   . .. ..  ...... . .  ||        |. |.|  ..
atfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlm
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1166-1262 1.1e-11 38.9 In-house 28-130 (347) alignment 
Range on Protein: 1166-1262
Range on HMM: 28-130/347.0
ECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKG-----TDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWD-HNAQIIVMLPDNQSLAEDE
.. |.. | . .|||   |   . .|| |.|    ..       |||||.|     |.|.|.||.|||.| .|||.|.   . .|.. ..   .  | .|
kftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaiee

FVY
|  
fan
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1166-1268 2.2e-10 33.7 In-house 18-89 (169) alignment 
Range on Protein: 1166-1268
Range on HMM: 18-89/169.0
ECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINAsyimgyyrsnefiitqhplphttkdfwRMIWDHNAQIIVMLPDnqslAEDEFVYWPS
. | |.  ||. ||| .. .   ..|| |  .    |.|||||                           ||||. || .||.| |    ..|   .|| 
nnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgd....tddknnfwpe

REE
.|.
ked
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1166-1268 2.7e-10 33.4 In-house 17-88 (169) alignment 
Range on Protein: 1166-1268
Range on HMM: 17-88/169.0
ECFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINAsyimgyyrsnefiitqhplphttkdfwRMIWDHNAQIIVMLPDnqslAEDEFVYWPS
. | |.  ||. ||| .. .   ..|| |  .    |.|||||                           ||||. || .||.| |    ..|   .|| 
nnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGd....tddknnfwpe

REE
.|.
ked
0037934 (Phosphotyrosine protein) phosphatases II 1167-1410 3.6e-49 162.9 In-house 2-241 (243) alignment 
Range on Protein: 1167-1410
Range on HMM: 2-241/243.0
CFSAQKECNKEKNRNSSVVPSERARVGLaplpgmKGTDYINASYIMGYyrsNEFIITQHPLPHTTKD----FWRMIWDHNAQIIVMLPDNQ-SLAEDEFV
.. |....|..||| |...| .. || |      .|.|||||..|...   . .|.||.|||.|..|    ||||.|... ..|||| . .   .|. . 
fsiallpenlsknrysdilpydhsrvkl......egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPsreESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEATQ-DDYVLEVRHFQCPKWPN----P-DAPISSTFELINVIKEE-----ALTRDGPTIVH
|||   ...... |||||.|         ...... . || .. ||....|.|...  ||     .  ... . .. .. . ||     || ..||..||
ywp...gevtygdftvtllseeh.....lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVH

DEYGAVSAGMLCALTTLSQQLeneNaVDVFQVAKMINLMRPG-VFTDIEQYQFIYKAMLSL
   |   .|.|.|. .. ..|   . ||.... |..  .||| ...  .||.|.|.|.| |
CsaGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallel
0049772 (Phosphotyrosine protein) phosphatases II 1167-1415 6.6e-33 110.1 In-house 38-284 (314) alignment 
Range on Protein: 1167-1415
Range on HMM: 38-284/314.0
CFSAQKECNKEKNRNSSVVPSErARVGLaPLPGMKGTDYINASYIMGYyrsNEFIITQHPLPHTTKDF----------WRMI--WDHNAQIIVM------
.  |....|..|||.  ..| .  ||.| |  ...|.|||||||. |.   . ||.||.||..|  ||          |||.  .|.|  .|||      
ilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------LPD-----NQSLAEDEFVYWpsreesmnceaftvtliskdrlclsneeqiiihdfilEAT--QDDYVLEVRHFQCPKWPNPDAPI
               |..     |.  |.|   .                                      | .  ....  .. .. .  .| ..||.
adelsrLdaAlgKtpllildgngneptaadlellk.....................................eelydpelferlgikylripvpDgsapl

SSTF-ELINVIKEEalTRDGPTIVHDEYGAVSAG--MLCALTTLSQQlenenaVDVFQVAKMINLMRP-----GVFTDIEQYQFIYKAMLSLVSTKE
.. | |....|.|    ..||..||   |   .|  ...|.  . ..      |.. .. ... |.||     | .   |||.||..|.| ......
ledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkllg......vsleealedvrlkRpinpnpgfieqleqyefilealleylkflk
subfamily_egg_pd Subfamily egg 1167-1409 9.8e-23 75.3 In-house 32-268 (307) alignment 
Range on Protein: 1167-1409
Range on HMM: 32-268/307.0
CFSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFvYWPSR
   | .. |.|| |.  |   . .|| |    |.   |.| | .. |    ||||..| ||  | .|||||..  . | ||||  ..   . |. |||  
lttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkesercey.ywpka

E-ESMNC--EAFTVTLISKDRlclSNEEQIIIHDFILeATQDDYVLEVRHFQCpKWPNpDAPISSTFELINVIKEealtRDGPTIVHDEYGAVSAGMLCA
| .|.     .. .. .  |.     .    .  . |    ||  . . |.|   . |  . . | ....  ...       |..|.|  |   |. | |
esdslvtvpGslrienlkvds...kadplfrvtklkl.vGgddeerflehwqg.dvnn.ssdvysplrvlrklrn....lskpvvvqdilGvskaatlva

LTT-LSQQLEN-ENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
. . | . |        | .  ... | |.     . .| |.|. .| 
ieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1167-1410 4.4e-20 66.5 In-house 29-268 (281) alignment 
Range on Protein: 1167-1410
Range on HMM: 29-268/281.0
CFSAQKECNKEKNRNSSVVPSERARVGLAP-LPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFV-YWP
|   ..  |..||| . .   . .|| |   .|  . |||| | ||   .    .|.|| |   |  |||||||. |.  |||| .      ..   |.|
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfp

sREeSMNCEAFtvtliskDRLCLSNEEQIIIHDFILEATQDDYVLE---VRHFQCPKWPNPDAPISSTFelINVIKEEALTRDGPTIVHDEYGAVSAGML
 |. .  |  |       |.| .| |.  . . ..    .  |  |   . |.   .||. . | ||    .  |  .  .|  | ..|   |   .| |
.rn.ahcclqf.......dklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessev..mlkilrkirarstppvihcsagvgrsgtl

CALTTLSQQLENENA-VDVFQVAKMINL-MRPGVFTDIEQYQFIYKAMLSL
 |.    | . .  .  |. |.   . .  |      ..|| .|.| .| .
maveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1168-1409 1.1e-37 124.6 In-house 37-275 (315) alignment 
Range on Protein: 1168-1409
Range on HMM: 37-275/315.0
FSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAE-DEFVYWPSR
 .|... | .|||   ..| ..||| |  .      |||||||| ..   . .| .| ||. . .|||||......  |||. . |         ||| |
rvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdr

-EESMNCEAFTVTLISkdrlcLSNEEQIIIHDFILEATQDdyVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCA
  .|..  .. |.|.|     |.   . ..  ...  ...     |  ||  .||.  ..   || ..||  .| .  ... . .||   |.  .|....
kadsvefGsikvells.....leadtdgvarklvtrksee..srtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvis

LTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
.    .|......||||.. |..   || .    |.| ||| |.| 
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavle
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1168-1413 6.1e-36 119.0 In-house 34-278 (281) alignment 
Range on Protein: 1168-1413
Range on HMM: 34-278/281.0
FSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAE-DEFVYWPSR
 ..... |..||| | .|  . .|| ..|    | ||||||... ||   .|.|.|| |.|.. ..||.|.|......|||.  .          |||  
taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPdd

EESMNCEAFTVTLISKDrlclsNEEQIIIHDFILeATQDDYVLEVRHFQCPKWPNPDAPISsTFELIN----VIKEEALTRDGPTIVHDEYGAVSAGMLC
.....   .||. ...      .... | . | |  ...    ||....  .||.  .| . | ||..    | | .   .. | ..|   |   .|   
nselkygdvtvkstaee.....ekatyierkfkl.eresgetreveqlaytaWPdhGvPat.tkellefrkevlkltekktkaplvihCsaGvGrtGtyi

ALTTLSQQLENE-NAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
|| .| ...|.| . .|| .| . .   |  .   . ||.|.|||.|  .. 
alDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldk
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1168-1409 4.1e-30 99.5 In-house 38-234 (392) alignment 
Range on Protein: 1168-1409
Range on HMM: 38-234/392.0
FSAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAedefvywpsre
 .|||| |..|||   ..| ..||| |  .  .  .||.||||| ..   . .| .| | . . .|||||....|.  |.|. . .              
tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd...........

esmnceaftvtliskdrlclsneeqiiihdfileatQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALT
                                    . | .  |  |.  .||. | |   || ...|. .| .      | |.|   |   .|.. .. 
....................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisid

TLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
..  . ..   ||||..   |   || .    ||| ||| |.| 
svvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1168-1414 7.1e-16 52.8 In-house 40-290 (305) alignment 
Range on Protein: 1168-1414
Range on HMM: 40-290/305.0
FSAQKE-CNKEKNRNSSVVPSERARVGLaplPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQ-SLAEDEFVYWPS
. | ||  ...|||   |   .. || |    |    .|| | |.     .. || || || .|  ||| | .... . | || . .   |.  . |..|
mkafkeaqeagknrykdvgcldnnrvkl...egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfas

REES-MNC----EAFTVTLISKDRLCLSNEEQIIIH--DFILEATQdDYVLEVRHFQCPKWPNPDAPISStFELINVIkEEALTRDGPTIVHDEYGAVSA
...  ..     .  .| . |  .| . .. .  .    ...| .    .. | |.    ||.   | .    ..... |.| .  ||..||   |   .
kdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpg.ekarkvthyhwidwpdrgvpaad.lailell.ekarpskgpivvhcsagigrt

GMLCALTTLSQQLENENAVDVF-QVAKMINLMR-PGVFTDiEQYQFIYKAMLSLVSTK
| .  |  . .|| . . ..   .. . |   |   . || .|| |... .|  .  |
gsvvmleyildqllagqiiedtdkilqkireqrnnsiqtd.aqylfvhqvilnyfrkk
0042113 (Phosphotyrosine protein) phosphatases II 1169-1410 2.4e-58 192.8 In-house 3-242 (245) alignment 
Range on Protein: 1169-1410
Range on HMM: 3-242/245.0
SAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPSrE
.|....||.|||.|...| .. || | | .|  ..|||||||. ||.... ||.||.|||.|..|||||.|... ..|||| .   |  .. . |||. .
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl.g

ESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEAL-TRDGPTIVHDEYGAVSAGMLCAL
||.... |||||.| .      .. ...  . .. ..||...||.|...  ||  ..|  ... ..... ...    ...||..||   |   .|...|.
esltygdftvtllseeh.....lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaa

TTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
 .. .||| |  |..... |... .|||...  .||.|.|.|.| |
ylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel
subfamily_PTPRK_pd Subfamily PTPRK 1169-1409 1.4e-51 170.2 In-house 37-275 (314) alignment 
Range on Protein: 1169-1409
Range on HMM: 37-275/314.0
SAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPsrE
.|.|. |.||||   ... .|.|| | .. |   .|||||..| .| |...||.||.||..|.|||||...|.|.  |||| . .. .      |||  |
aakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWP..e

ESMNCEAFTVTLISKDRlclsnEEQIIIHDFILEA--TQDDYVLEVRHFQCPKWPNPDAPISST--FELINVIKEEALTRDGPTIVHDEYGAVSAGMLCA
...  . . |.|.. .      ......  | .|    . . . |||.||  .||. | | | |  ..|.  .|.    ..|...||   ||  .|. .|
dtevygdikvelvetel.....laelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfia

LTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
.... . .|.|. ||||...| .   .. .    |||.||| ..| 
idivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1169-1413 2.4e-36 120.0 In-house 32-279 (287) alignment 
Range on Protein: 1169-1413
Range on HMM: 32-279/287.0
SAQKECNKEKNRNSSVVPSERARVGLAPlPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSRE
.|..  . .||| . |.| . .|| |.   | .|.||||| |. .| . ..|| .| |.. | .||||.......  ....  .   |  . . ||| ||
aaeelaavkknryadvlPiddtrvllsa.egelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPere

ESMNCEAFTVTLISKDRLclSNEEQIIIHDFILEATQDDYVleVRHFQCPKWPNPDAPIS---STFELINVIKEEALTRD----GPTIVHDEYGAVSAGM
  |    ..|.|...| .  . |  .     |   |..  |  |. ..  .||.  .. .        ..| .   |.||    || .|||. |.  .|.
vPmrvGGysvvlldydik..ePeygvralrlidletrearv..vkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGi

LCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
| |. .| ..||.   ||| .|   .   | ..   . |....|.|. .   |
llatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyykt
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1169-1411 2.5e-36 120.4 In-house 42-288 (325) alignment 
Range on Protein: 1169-1411
Range on HMM: 42-288/325.0
SAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVYWPSR-E
 | |  ||.|||   ||. ...|| |  .     .|||||||.  . . . |. .| ||..|..|.||.. | .. ..|.|   .   .   |||| .  
vamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlneldlgkdrcavywpkemg

ESMNCEAFTVTLISKDRLclSNeeqIIIHDFILEATQDDYVLEVRHFQCPKWP---NPDAPIS--STFELINVIKEEALT---RDGPTIVHDEYGAVSAG
.| .  .. | |.. . .  |.    .   . .  ...   . |. ||   |.   ..  | .  |  .|.. ..|   .     .| .||   |   .|
ksktfGglevklrtieei..sd...yvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcsaGvGrtG

MLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV
.. .| .. ... .|  ||.|.. | .   || .   ..|| .||.|.   .
vfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1169-1409 1.9e-35 117.0 In-house 37-274 (515) alignment 
Range on Protein: 1169-1409
Range on HMM: 37-274/515.0
SAQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSlaEDEF---VYWPS
 ||.| | .|||   ..| ...|| |  .      ||.||||| ..   . .| .| |.. ...||||.....|   |.|. . .   .|      ||| 
vaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklke..gdkikcgkyWPd

-REESMNCEAFTVTLISkdrlcLSNEEQIIIHDfiLEATQDDYVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLC
   .|..   . | |.|     |.   . |.    |. ...| .  |  |.  .||.  .|   || . ||  .| .      | |.|   |.  .|...
kpgdsvkfGsikvelvs.....leactggikrk..ltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvi

ALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
..     . .. ..||||.. . |   || .    ||| ||| |.| 
sidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavle
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1169-1224 7.1e-06 20.1 In-house 42-94 (95) alignment 
Range on Protein: 1169-1224
Range on HMM: 42-94/95.0
SAQKECNKEKNRNSSVVPSERARVGLAplpGMKGTDYINASYIMGYYRSNEFIITQ
    |.|  |||   ..| . .|| |.     . .||||| .. || | | .| .|
vgsseanipknrflnifpydatrvvlt...tkrdsdyinacfvdgyarkncyiaaq
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1170-1415 1.7e-47 156.8 In-house 4-246 (250) alignment 
Range on Protein: 1170-1415
Range on HMM: 4-246/250.0
AQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVYWPSrEES
|.|  |||||| . ... . .|| | .  | | .||||||.. ||  .. ||.||.||..|..|||||....... |||| . .   .    |||  |..
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPv.eka

MNCEAFTVTLISKDRLClsneeQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVIKEEALT-RDGPTIVHDEYGAVSAGMLCALTT
 .    ||.| ||.         .... ..|  ..      ||...   ||.   |    . .||.. .. .     ..| ||.   |   .|  .|. .
ekyGdvtvsllskeefa.....dytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida

LSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKE
. ..|..|. ||||.| |..   ||.. .  ||| |.|...|  . . |
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1170-1410 8.8e-44 144.7 In-house 44-278 (315) alignment 
Range on Protein: 1170-1410
Range on HMM: 44-278/315.0
AQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFV-YWPSRee
|.|  ||.|||   ... ...|| |  |   ...||.||..| || . . .| .| |.. . |||||......   |||| .  .  .     ||| .  
akkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk..

SMNCEAFTVTLISKDRlclsnEEQIIIHDFilEATQDDYVLEVRHFQCPKWPNPDAPISST--FELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTT
 .    .|||..|..      .... .  .    . .| . ||  ..   ||. . | ...   .||  .|    .  |. .|| . |   .| ...| .
kviyGkitvtrkseev.....nteytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitlda

LSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
. .|.| |||.||... . .  .| ..   .|||||||.|.|  
vldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1170-1408 2.1e-24 81.0 In-house 2-237 (239) alignment 
Range on Protein: 1170-1408
Range on HMM: 2-237/239.0
AQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSN-EFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQ-SLAEDEFVYWPSRe
|.|  || ||| . .|  ...|| |  |     .|||||||.  |  |   .| ||  .  .. |||||.|.    .||||        .  . |||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.

ESMNCEaFTVTLISKDRLClsneeQIIIHDFILEA---TQDDYVLEvrhFQCPKWPNPDAPISST--FELINVIKEEALTRDGPTIVHDEYGAVSAGMLC
 |  |. . |||   . ..     . ||. |..     |.. || .   ..   ||.   |  .|  . |   | ...|    | ..|   |   .| . 
tskycn.lrvtlrktevfa.....dyiirtfvmsqvgqteeryvyq...yhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgafl

ALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAML
 . .. .| .....||.|.  | |   || .    ||| ||. |.|
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1170-1408 2.2e-24 80.9 In-house 3-238 (239) alignment 
Range on Protein: 1170-1408
Range on HMM: 3-238/239.0
AQKECNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRSN-EFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQ-SLAEDEFVYWPSRe
|.|  || ||| . .|  ...|| |  |     .|||||||.  |  |   .| ||  .  .. |||||.|.    .||||        .  . |||   
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.

ESMNCEaFTVTLISKDRLClsneeQIIIHDFILEA---TQDDYVLEvrhFQCPKWPNPDAPISST--FELINVIKEEALTRDGPTIVHDEYGAVSAGMLC
 |  |. . |||   . ..     . ||. |..     |.. || .   ..   ||.   |  .|  . |   | ...|    | ..|   |   .| . 
tskycn.lrvtlrktevfa.....dyiirtfvmsqvgqteeryvyq...yhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgafl

ALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAML
 . .. .| .....||.|.  | |   || .    ||| ||. |.|
vidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1171-1411 2.8e-14 47.4 In-house 49-289 (305) alignment 
Range on Protein: 1171-1411
Range on HMM: 49-289/305.0
Q--KECNKEKNRNSSVVPSERARVGLAPLPgmkGTDYINASYIMG-YYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSR
.   . .. ||| . |   ... | |.  .    .||| | |.       . || .| || .|  .|| |. ... . ||||     |       |||  
nqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaa

-EESMNCEAFTV-TLISKDRlCLSNEEQIIIHDFILEAtQDDYVLEVRHFQCPKWPNPDAPIS--STFELINVIKEEALtrdgPTIVHDEYGAVSAGMLC
  | ..  .  |   .|  .  .  . .| |  . |     |  . |||.|  .||.   |    ...||.  |.   .    | .||   |   .| . 
qgeklelksgivvenvsgsk.pmerdaeiqitllnlty.sgdqkmsvrhlqwtewpdrgvppckltslellsairgskv....pivvhcsagigrtgtiv

ALTTL-SQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV
|.  .  .  || ..  . .. | .   |     .  || ||.. ||  .
aieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1172-1295 5e-18 59.6 In-house 93-211 (244) alignment 
Range on Protein: 1172-1295
Range on HMM: 93-211/244.0
KECNKEKNRNSSVVPSERARVGLAplPGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDnqslAEDEFVYWPSREES-M
.  |  |||... .| .  || |.   |  |  |||||..    |. |.|.|||||  |. |||.|. .   ...|.|       |.|  |||  |    
npnnswknregaglpfdfnrvpls..kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgs....veeedeywpdseplew

NCEAFTVTLISKDRLCLSNEEQIII
  |  ||||  .| .      .. |
yeeditvtltdrdefknikasnlei
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1174-1409 6.5e-39 128.7 In-house 27-266 (274) alignment 
Range on Protein: 1174-1409
Range on HMM: 27-266/274.0
CNKEKNRNSSVVPSERARVGLAPLPGMK-GTDYINASYIMGY-YRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAE-DEFVYWPSREESM
 ...|||  ...| |..|| | .  . .  ..|||| || || ..|. .. || |||.| .||||||. ...|.|||| . .   |    ||.| .|.  
gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedye

NCEAFTVTLISKDRLClsNEEQIIIHDFILEATQDdyVLEVRHFQCPKWPNPDAPIS--STFELINVIKEEA---LTRDGPTIVHDEYGAVSAGMLCALT
  | ..   |  .     ....  .. ..|. ...    .| |.  ..||. ..| .  . ..|.. ..|..    .. .|..||   |   .|.  | .
iserygdveikvekiv..erndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

TLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
   .||..|. |||...   . | | |.    |||..|..|.  
iavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl
subfamily_CG42327_pd Subfamily CG42327 1174-1328 2.1e-18 61.1 In-house 27-180 (319) alignment 
Range on Protein: 1174-1328
Range on HMM: 27-180/319.0
CNKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYRS-NEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPSREESMN
  |.|.|   |||   .|| |   .  . . |..|||. ||  . | .| .| .|  .. ||||..|. ....|| | | . |  .    |.|..|   |
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

CEAFTVTLISK-DRlclSNEEQIIIHDFILEATQDDYVLEVRHFQCpKWPNPDAPISS
 ...   |..  .|     ... .|  ..|   ...   |. |.   ||.. . | . 
tslyGdilvtlkgr...evkdryaistlllkrvdkeesrelthywy.kwleaevPaee
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1174-1409 1.2e-10 35.6 In-house 46-277 (303) alignment 
Range on Protein: 1174-1409
Range on HMM: 46-277/303.0
CNKEKNRNSSVVPSERARVGLAplpgmkGTDYINASYImGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVM-LPDNQS-LAEDEFVYwPSREESMN
 | .|||   |.  . ..| |.       . || |||.     |.  |.|| ||.||. |||.|| . . . ... | |..      ..|. |  .. ..
knmdknrfvdvicldhskvkls......dssyihasyl.eldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvf.prnqdflk

CEAFTVTLISKDRLCLSNEEQIIIhdFILEATQDDYVLEVRHFQcpKWPNPDAPISSTFELINVIKE-----EALTRDGPTIVHDEYGAVSAGMLCALTT
 |  .. .    |. |..  .. .    .   .    | | |..  .||  . |  .. .... | .        .   ||.     |   || .. . |
feersirvgefkrvelgdgwvlkv..lsvsngdyksflhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfet

LSQQLENENA-VDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLS
    | .|.| .|. .. ...   |     .. |. ..|  .  
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
Y_phosphatase Protein-tyrosine phosphatase 1175-1408 1.9e-58 193.1 Pfam-A 1-234 (235) alignment 
Range on Protein: 1175-1408
Range on HMM: 1-234/235.0
NKEKNRNSSVVPSERARVGLaplPGMKG-TDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSL-AEDEFVYWP-SREESMN
||.|||.....| .. || |    | .| .|||||.|..|| ....||.||.||..| .|||||.|... ..|||| ...    |    ||| ..|||..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

CEAFTVTLIskdRLCLSNEEQIIIHDFILEATQDD-YVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLS
.. ..|.|        ..|........ |. ....    ||..... .||. ..|   .| ..||. ....  ...||..||   |.  .|...|| .| 
ygdikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

QQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAML
.|||.|. |||.|. |..   |||.....|||.|.|||.|
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
Y_phosphatase Protein-tyrosine phosphatase 1175-1408 1.9e-58 193.1 In-house 1-234 (235) alignment 
Range on Protein: 1175-1408
Range on HMM: 1-234/235.0
NKEKNRNSSVVPSERARVGLaplPGMKG-TDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSL-AEDEFVYWP-SREESMN
||.|||.....| .. || |    | .| .|||||.|..|| ....||.||.||..| .|||||.|... ..|||| ...    |    ||| ..|||..
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

CEAFTVTLIskdRLCLSNEEQIIIHDFILEATQDD-YVLEVRHFQCPKWPNPDAP--ISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLS
.. ..|.|        ..|........ |. ....    ||..... .||. ..|   .| ..||. ....  ...||..||   |.  .|...|| .| 
ygdikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldill

QQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAML
.|||.|. |||.|. |..   |||.....|||.|.|||.|
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail
0041856 (Phosphotyrosine protein) phosphatases II 1175-1411 9.2e-36 118.5 In-house 1-171 (182) alignment 
Range on Protein: 1175-1411
Range on HMM: 1-171/182.0
NKEKNRNSSVVPSERARvglaplpgmkGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPdnqslaedEFVYWPSREesmncea
|..||| | ..| .. |          . |||||....|......||.||.||..|. ||.||..... ..||.|         |. |||...       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywpell.......

ftvtliskdrlclsneeqiiihdfileatqDDYVLEVRHFQCPKWPNPDapISSTFELINVIKEealtRDGPTIVHDEYGAVSAGMLCALTTLSQQlene
                               ...........| .. ||  .......|. ..|    ..||..||  .|   .|.|.|.  . ..    
..............................erlgiqylylpwpDhgvpd..ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....

nAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLV
  |..... |... .|||...  .||.|.. |.| |.
.gvsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1175-1413 5.6e-34 112.4 In-house 20-266 (270) alignment 
Range on Protein: 1175-1413
Range on HMM: 20-266/270.0
NKEKNRNSSVVPSERARVGLAPLPGMKGTDYINASYIMGYYR-SNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPSREES-MN
.|. ||   ..|| ..|| |..|   . | |||| |. |.   ....| .. ||| |.|.||||||..... |||. . .    ..  .|||.. .. ..
gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekvk

CEAFTVTLISKDRlclSNEEQIIIHDFILEaTQDDYVlEVRHFQCPKWPNPDAPISST-----FELINVIKE-----EALTRDGPTIVHDEYGAVSAGML
.|. ... ..      ..||  |.    || .. .   .. ||.  .||.  .| ..       .|......     . | . .|..||.  |   .|.|
ledgkikvlalse...ekeegyiltrlrle.ekgeer.rlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllvHcsaGvgRtGtl

CALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVST
 || .  . ||... ||| .. . .   |. .    |||.|.|||..  ...
ialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1175-1408 5.1e-24 79.8 In-house 3-236 (237) alignment 
Range on Protein: 1175-1408
Range on HMM: 3-236/237.0
NKEKNRNSSVVPSERARVGLAPlPGmKGTDYINASYIMGYYRS-NEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAE-DEFVYWPSREESMNC
|| ||| ...|  . .|| |   .|  |.|||||.|. |.  . ...| .| ||  . .|||.|.|. .  .||||       |     |||| ..    
nkiknrygnivaydhsrvvlkg.ag.sgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

EAFTVTLISKDRLCLSNEEQIIIHdfiLEATQDdYVLEVRHFQCPKWPNPDAPISSTFEL---INVIKEEAL-TRDGPTIVHDEYGAVSAGMLCALTTLS
  .||.|  |. ..      ...     . |.   |  .  .|   ||.   |  ..  |    |.|..    .. || |.|   |   .|..  . .. 
gvltvslkkkeefsdytvrsllls...krltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml

QQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAML
.| .... ||...  . |.  || .    .|| ||....|
rqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil
subfamily_eak_pd Subfamily eak 1175-1338 1.3e-07 25.3 In-house 52-209 (332) alignment 
Range on Protein: 1175-1338
Range on HMM: 52-209/332.0
NKEKNrNSSVVPSERARVGLAPLpGMKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPSRE-ESMNC
. ..|    .|| .|  | |..   .    ||||| .      ...|.|  .       ||.|. . ..  ||.| ..  |  |    |.| .  | .. 
avnrn.vvkivpydrylvrltss.qlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkf

EAFTVTlisKDRLcLsneEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISSTF-ELINVIKE
  . |.   .    .   .. |..   || .. .   .| |..   | . . |.   |  | .|.||
Gildve...rkef.v...krniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmke
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1175-1251 1.8e-07 25.0 In-house 34-109 (332) alignment 
Range on Protein: 1175-1251
Range on HMM: 34-109/332.0
NKEKNRNSSVVPSERARVGLAPLPGMkgTDYINASYIMGYYRSNEFIITQHPLP-HTTKDFWRMIWDHNAQIIVMLPD
| . ||   .   ...|| |||  |    |. |||.. || . . .|..| |.  ||   ||||. ...  .|... |
nmdmnriphlycfdhsrvelapqdgk..ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1177-1282 1.1e-13 45.6 In-house 49-165 (350) alignment 
Range on Protein: 1177-1282
Range on HMM: 49-165/350.0
EKNRNSSVVPSERARVGLA--PL------PGMKGTDYINASYIMGY----YRSNEF--IITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSL-AEDEFV
 ||| . ..| |..|| |   .         ... |||||.|.           .|  | || ||| | .||...|   . ..|..| ... |  |    
aknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyr

YWPSreesMNCEAFTVTLISK
||.      . . .|| | ||
YWqe....gsydditvklask
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1177-1408 3.6e-09 31.1 In-house 45-268 (288) alignment 
Range on Protein: 1177-1408
Range on HMM: 45-268/288.0
EKNRNSSVVPSERARVGLAplpgmKGTD-YINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPSRE-ESMNCE
 ..|   .   . .|| |        .| ||.|  .      . .| .| ||  | . .|.|. . . . |||| .   .  |   .|.||.  |..   
trdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekarig

AFtVTLISKDRlclSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPI--SSTFELINVIkeEALTRdgPTIVHDEYGAVSAGMLCALTTLsqqL
 .  | . |.|   .. ....    .    . .    |..    .|..   |    | . |..|.  ..|..  | .|| . |.  .| |         |
rl.ctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl..kslqk..PivvhssaGvGrtgtlililia...l

ENENAVDVFQVAKMINLMRPGVFTDI---EQYQFIYKAML
|    .|   . .... .|   |  |    || .... .|
eslrlddflgirsllaklreerfkaiqtemqylyvhrcvl
0044763 (Phosphotyrosine protein) phosphatases II 1186-1411 4.6e-23 77.2 In-house 1-171 (178) alignment 
Range on Protein: 1186-1411
Range on HMM: 1-171/178.0
PSERARVGLAPLPGMKGTDYINASYIMGYyrsneFIITQHPLphttKDFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPSREEsmnceaftvtliskdr
| .| || | .|.|. ..||||||.|...     ......|      |......... . ||.| ... |  .... |||....                
pldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag................

lclsneeqiiihdfileatqddyvLEVRHFQCPKWPNPDapISSTFELINVIKEEAL-TRDGPTIVHDEYGAVSAGMLCALTTLSQQlenenAVDVFQVA
                        ....|. .| ...||  ... |. .  . |||| ...||..||  .|   .|.|.|.  . ..      ...... 
........................iqylhipipDhgvpd..llehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeai

KMINLMRPgVFTDIEQYQFIYKAMLSLV
...  .|| ...  .|....|.  | | 
elvrerRp.ivpnpgqlrqLyefelrll
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1199-1265 2.5e-08 27.7 In-house 86-155 (349) alignment 
Range on Protein: 1199-1265
Range on HMM: 86-155/349.0
GMKGTDYINASYIMG--YYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDE-FVYWPS
. |  ||||| |.    .   . .| || ||| | .||...|   . .... | |.. |. .   .||  
sgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqe
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1200-1320 8.7e-13 42.7 In-house 10-122 (130) alignment 
Range on Protein: 1200-1320
Range on HMM: 10-122/130.0
MKGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDnqslAEDEFVYWPSREESM-NCEAFTVTLISKDRLCLSNEEQIIIHDF
..| .|||||..    |..|.. |||||  |. |||.|. .    ..|.|       |.|  |||  |      |  .|||  .|     . ... |.. 
lqgntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgs....veeedeywpdsePlewyeediivtltdrdefknikasnleiesd

ILEATQDdyvleVRHFQCPKWP
. |. |      .  ||  .||
lneshqa.....ltmfqisnwp
0043147 (Phosphotyrosine protein) phosphatases II 1201-1404 4.1e-27 90.4 In-house 3-154 (172) alignment 
Range on Protein: 1201-1404
Range on HMM: 3-154/172.0
KGTDYINASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNqslaedefvywpsreesmnceaftvtliskdrlclsneeqiiihdfil
.|.|||||||. .||  ..||.|| ||..|. |||||..... ..||.| .                                                 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

EATQDDYVLEVRHFQCPKWPNPDAPISSTFELINVIKEE--ALTRDGPTIVHDEYGAVSAGMLCALTTLSqqleneNAVDVFQVAKMINLMRPGVFTDIE
. . .... .. ....  ||  ..|... .. .  . .|  || ..||..||  .|   .|.|.|.  .         ...... ...  .|||...  .
lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYQFIY
||.|.|
qyrfly
0046846 (Phosphotyrosine protein) phosphatases II 1201-1410 2e-26 88.2 In-house 10-172 (176) alignment 
Range on Protein: 1201-1410
Range on HMM: 10-172/176.0
KGTDYINASYIMGYYrsneFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAEDEFVYWPSREESMNCeaftvtliskdrlclsneeqiiihdfil
 . |||||..|.|..    .|.||.|||.|. ||..|..... ...|.| . . |.   . ......|....                            
ldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

eatqddyvlevrHFQCPKWPNPDAPISSTFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTtlsqQLENENAVDVFQVAKMINLMRP-GVFTDIEQ
            ....  ||  ..| .. .. .  . .|||...||..||   |   .|.|.|.      || |. ..|... ...  .|| |...  ||
............qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpeQ

YQFIYKAMLSL
|.|.|...| |
yrflyefelll
0036282 (Phosphotyrosine protein) phosphatases II 1202-1405 2.1e-31 104.4 In-house 1-164 (174) alignment 
Range on Protein: 1202-1405
Range on HMM: 1-164/174.0
GTDYINASYIMGYYRSNEFIITQHPLPhttkdFWRMIWDHNAQIIVMLPDNQSLA-EDEFVYWPSreesmnceaftvtliskdrlclsneeqiiihdfil
|.||||||.. ..|.....|..|.||.     ||.|..... ...||| . . |  .  . |||.                                   
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

eaTQDDYVLEVRHFQCPKWPNPDAPISSTFELINVIKEEALTR--DGPTIVHDEYGAVSAGMLCALTTLSQQLEnENAVDVFQVAKMINLMRPGVFTDIE
  ...|.. .. ....  ||   .| .|... .  . |||| .  .||..||   |   .|.|.|.  . ..|. |..||.... ... |.|||...  .
..lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtps

QYQFIYK
||.|.|.
Qyrflyy
0051429 (Phosphotyrosine protein) phosphatases II 1202-1410 6e-29 96.9 In-house 3-224 (272) alignment 
Range on Protein: 1202-1410
Range on HMM: 3-224/272.0
GTDYINASYIMGYYR---SNEFIITQHPLPHTTKDFWRMiWDHNAQIIVMLPDNQSLAEDE-FVYWP-----------SREESMNCEAFTVTLISKDRLC
 ..||||... ||.|    . .. ...|||.| .||||. ....   ||.| .   .. .  . |||           . .....  |..|||.|.  | 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

LsneeqIIIHDFILEAT-QDDYVLEVRHFQCPKWPNPDAPISSTFELINVIKEealtrDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVD-------
      .|.  ..|. . . . ..||.|...  ||   .| ..  ||.... .     .|| .||   |    |...||  | .... |  ||       
d.....yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VFQVAKMINLMRPGVFTDIEQYQFIYKAMLSL
 .... ...  .|||.. . |||.|.|.|.| |
yleeaveelraqrpgavqteeqylflyeallel
0051082 (Phosphotyrosine protein) phosphatases II 1203-1407 5.3e-22 73.5 In-house 3-149 (151) alignment 
Range on Protein: 1203-1407
Range on HMM: 3-149/151.0
TDYINASYIMGYyrsneFIITQHPLPhttkDFWRMIWDHNAQIIVMLPDNQSLAeDEFVYWPSREesmnceaftvtliskdrlclsneeqiiihdfilea
.||||.||. |.     ......||.    ||........ . ||.| . .  .  .  |.|. .                                   
sdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg.ycpeylpelg...................................

tqddyvLEVRHFQCPKWPNPDAPI--SSTFELINVIKEealTRDGPTIVHDEYGAVSAGMLCALTTLSQQlenenaVDVFQVAKMINLMRPGVFTDIEQY
      .||.|.... ||.|. |.   .  |..... .   ...||..||   |    |.|.||  . ..      |..... ... |.||||..  .|.
......ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

QFIYKAM
.|...|.
lfqlfal
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1203-1411 1.4e-09 32.5 In-house 46-260 (290) alignment 
Range on Protein: 1203-1411
Range on HMM: 46-260/290.0
TDYINASYIMgYYRSNEFIITQHPLPHT-------TKDFWRMIWDHNAQIIVMLPDNQSLAED--EF---VYWPSREE-SMNCEAFTVTLISKdrlclSN
 ||| |...  .    ..|.|| |. ..        ..|| |. . ... .||| ...   ..  .|    | | ... ... . .||   ||      .
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCksk.....ek

EEQIIIHDFILEaTQDDYVLEVRHFQCPKWPNPDAPiSSTFELINVIKEEAlTRDGPTIVHDEYGAVSAGMLCALTTLSQQLE-NENAVDVFQVAKMINL
|.....   ...  .|.  . | | .   | .  ..  .|  |...|.    ... | |||.  |     .| |.    | .   ...| . .| |..  
eddvetRelvvk.fddeeeftvtHsllkgWnklnvq.edtktllsliqkvk.asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkalrk

MRPGVFTDIEQYQFIYK-AMLSLV
.|  ..|. ... |.   ..| ..
qralaitsalelafvdagivllai
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1206-1390 8.5e-17 55.8 In-house 78-260 (301) alignment 
Range on Protein: 1206-1390
Range on HMM: 78-260/301.0
INASYIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAED-EFVYWPSR-EESMNCEAFTVTLISKDRLClsnEEQIIIHDFILEAT
| | .|    ... ||.|| ||. |..||| |.  .. . ||||  .    |.    | |.. .|... . |.... .|. .    ...|.   . .| .
ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelil...nkkiskrtleveds

QDD-YVLEVRHFQCPKWPNPDAPIS--STFELINVIKEEaltrDGPTIVHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMR
 ..     | |.|  .|.. . | |   .|.|....|.     . | .||   |   .  . .   |....|... ... .  | ..  |
tgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhcsaGiGrsvafigteylareveadptieltealkhlrehr
0049260 (Phosphotyrosine protein) phosphatases II 1210-1405 3.2e-22 74.3 In-house 1-144 (152) alignment 
Range on Protein: 1210-1405
Range on HMM: 1-144/152.0
YIMGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAED-EFVYWpsreesmnceaftvtliskdrlclsneeqiiihdfileatqddyv
.| ||....|||.||.|.|.|..|||||........|||| . . |... .  |.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

levRHFQCPKWPNPDAPISSTFELINVIKEE-ALTRDGPTIVHDEYGAVSAGMLCALTTLSqqleneNAVDVFQVAKMINLMRPGVFTDIEQYQFIYK
   .....|   ..  ..|  .. .. . |. || ..||..||  .|   .|.|.|.  .       . |..... ...  .|||...  .|..|.|.
...qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1212-1320 4.6e-11 36.7 In-house 230-329 (440) alignment 
Range on Protein: 1212-1320
Range on HMM: 230-329/440.0
MGYYRSNEFIITQHPLPHTTKDFWRMIWDHNAQIIVMLpdNQSLAEDEFVYWPSREESMNCEAFTVTLISKDrlclsNEEQIIIHdfILEATQDDYVLEV
 || . | || || ||  |  ||||.. |..   |.||  ||       .|||    |.    |||     .     | ... .    ||    . | |.
egyskknafiatqmpldstvldfwrlvhdyristiiml..nqlndktcsiywpvntrsvtfgpftvghkgse.....nmnrvkvr..tlelkykeevhei

RHFQCPKWP
| |.   ||
rqfevqtwp
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1219-1405 2.4e-20 67.5 In-house 5-197 (198) alignment 
Range on Protein: 1219-1405
Range on HMM: 5-197/198.0
EFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAE-DEFVYWPSREESMnCEAFTVTLISKdRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCP
 .| ||||| .|  |||.|.|.  .  |||. |.|   | |  .|||. | .   .  .... .|  ..   .  |    .  ..|      |. |.|  
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgt.gkygslsvttk.tittkpdytitaliltnnttappstreishyqft

KWPNPDAPISSTFELI-----NVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLE--NENAVDVFQVAKMINLMRPGVFTDIEQYQFIYK
 | .  .|  . |  .     .| |     .| | |||   |   .|.. ||    .  |  .   ||.|.||| .   | |. . ...|.|||.
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1219-1405 2.5e-20 67.5 In-house 6-198 (199) alignment 
Range on Protein: 1219-1405
Range on HMM: 6-198/199.0
EFIITQHPLPHTTKDFWRMIWDHNAQIIVMLPDNQSLAE-DEFVYWPSREESMnCEAFTVTLISKdRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCP
 .| ||||| .|  |||.|.|.  .  |||. |.|   | |  .|||. | .   .  .... .|  ..   .  |    .  ..|      |. |.|  
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgt.gkygslsvttk.tittkpdytitaliltnnttappstreishyqft

KWPNPDAPISSTFELI-----NVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQQLE--NENAVDVFQVAKMINLMRPGVFTDIEQYQFIYK
 | .  .|  . |  .     .| |     .| | |||   |   .|.. ||    .  |  .   ||.|.||| .   | |. . ...|.|||.
swkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyq
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1231-1426 3.5e-07 23.2 In-house 131-323 (346) alignment 
Range on Protein: 1231-1426
Range on HMM: 131-323/346.0
TKDFWRMIWDHNAQII-VMLPDNQsLAEDEFVYWpsREESMNCEAFTVTLISKDRLCLSNEEQIIIHDFILEATQDDYVLEVRHFQCPKWPNPDAPISST
 .||| ||.. . ... .|.||.. | .     .   .|    .     .| . |  .| . .    . . |   |  . .| |    |  .        
vedfwymiyqeqihlvylmvpddk.lkntttslf..ndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsvicqvhhhapwkhlqqppktlpi

FELINVIKEEALTRDGPTIVHDEYGAVSAG-MLCALTTLsQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAMLSLVSTKENGNGpMTVDKN
  .|  .. |   ..    |   .|.  |  .. || .. .||.|    ..... | |   |||    . ||  ||  ..  .. |  |     |.|.
ikmihqflsekqvqnagvcvvslfgcgracsfigalyai.nqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiarkrggkk.apvnkd
0048179 (Phosphotyrosine protein) phosphatases II 1295-1405 2.7e-07 25.9 In-house 33-139 (144) alignment 
Range on Protein: 1295-1405
Range on HMM: 33-139/144.0
IHDFILEATQDDYVLEVRHFQCPKWPNPDAPIS-STFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSqqlenENAVDVFQVAKMINLMRPGV
. ... |  ....  |. ....  ||. ..| . . .. .  . |||| ..||..||  .|   .|.|.|.  .      .. ...... ...  .|||.
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmk.....klglsleealalvrsrrpga

FTDIEQYQFIYK
..  .|..|...
vpnpgqlrfLle
0048076 (Phosphotyrosine protein) phosphatases II 1300-1408 6e-09 31.3 In-house 36-140 (145) alignment 
Range on Protein: 1300-1408
Range on HMM: 36-140/145.0
LEATQDDYVLEVRHFQCPKWPNPDAPIS-STFELINVIKEEALTRDGPTIVHDEYGAVSAGMLCALTTLSQqlenENaVDVFQVAKMINLMRPGVFTDIE
|  ...... .. ....  ||  ..| . .... .  . |||| ..||..||   |   .|.|.|.  . .    .. |..... ...  .|||...  .
ltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealelvrsqrpgavpnpg

QYQFIYKAML
|..|.|.. |
qlrflyefel
PTPc_DSPc_SM00012 1311-1408 2.1e-20 68.3 In-house 2-104 (105) alignment 
Range on Protein: 1311-1408
Range on HMM: 2-104/105.0
VRHFQCPKWPNPDAPI--SSTFELINVIKEEALTRD--GPTIVHDEYGAVSAGMLCALTTLSQQLENE-NAVDVFQVAKMINLMRPGVFTDIEQYQFIYK
|.|.....||.  .|   .| .||.. .|..   ..  .|..||.  |.  .|...|| .| ||||.| . ||.||. |..  .|||...  |||.|.|.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AML
|.|
all
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1338-1407 1.5e-07 25.1 In-house 364-434 (440) alignment 
Range on Protein: 1338-1407
Range on HMM: 364-434/440.0
EEALTRDGPTI-VHDEYGAVSAGMLCALTTLSQQLENENAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAM
|..   ||| | ||   |   .|..|..    .||.|. |.||||  ... | ||     . .| . || .
eqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyllcykll
subfamily_CG42327_pd Subfamily CG42327 1342-1407 2e-06 21.7 In-house 245-311 (319) alignment 
Range on Protein: 1342-1407
Range on HMM: 245-311/319.0
TRDGPTIVHDEYGAVSAGMLCALTTLSQQLENE-NAVDVFQVAKMINLMRPGVFTDIEQYQFIYKAM
 . || .||   |.  .|.. |     ..||.  ..||. |.   .   |     ..|||.|||| .
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvl