Gene PTPRZ1 in Homo sapiens

Synonym: HPTPZ, HPTPzeta, PTP-ZETA, PTP18, PTPRZ, PTPZ, R-PTP-zeta-2, RPTPB, RPTPbeta, phosphacan, PTPRZ1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRG
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP100_AA protein Get Run
HsapP100_AA_1699-1994 phosphatase_domain Get Run
HsapP100_AA_2005-2284 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Carb_anhydrase Eukaryotic-type carbonic anhydrase 38-299 9.9e-60 188.9 Pfam-A 1-255 (256) alignment
Range on Protein: 38-299
Range on HMM: 1-255/256.0
WSYTGALNQKNWGKKYPTCNSPKQSPINIDEDLTQVNVNLKKLKFQGWDKTSLentFIHNTGKTVEINLTN---DYRVSGGVSEMVFKASKITFHWGKCN
|.|    ....| |.||...  .||||||.   .... .||.|.. . ..|.     | |.|..|...| .   .  .|||  |  ... .. ||||...
WgyeeeaeeeewsklypiakgerqsPiniktkeakydpsLkplslsydeatak...eivnnGhsvqvelddssdksvlsggpleasyrlkqlhfHWgsse

msSDGSEHSLEGQKFPLEMQIYCFDADRFSSFEEAVKGKGKLRALSILFEVGtEENLDFKAIIDGVESVSRFGKQAALDPFILLNLLPNsTDKYYIYNGS
  . ||||...|.|.. |. .  ... ...|..|||| .  |  |..| .|| .||  .....| .|..   ||.|.|  | . .|||. . .|. |.||
..ekGsEHtvdgkkyaaElHlvHwnsskyksvkeAvkkedglAvlgvllkvg.keneelqklvdaLeeiktkgksatltnfdpstllPk.lrdywtYeGs

LTSPPCTDTVDWIVFKDTVSISESQLAVFCEVLTMQQSGYVMLmdyLQNNFREQQYKFSRQVFSS
|| ||....| |||.|.....|..||. . . |. ..    .    |..|.|  |   .|.| .|
lttPpleEsvtWivlkepikvsseqllklrslllsaegeeeve...lvdnyRplqpLkdRvvras

fn3 Fibronectin type III domain 313-401 5.6e-14 45.2 Pfam-A 1-85 (85) alignment
Range on Protein: 313-401
Range on HMM: 1-85/85.0
SEPENVQADPENYTSLLVTWERPRvVYDTMIEKFAVLYQQLDGEDqTKHEFLTDGYQDlGAILNNLLPNMSYVLQIVAICTNGlYGKYS
|.|||..... . ||| ..|. |.   .  |... | |.. .|..  ..|| ... ..  ..|..| |...|.... |. ..| .|..|
saPenlsvsevtstsltlsWsppk.dgggpitgYeveyrekggge.ewkeftvprttt.svtltgLkpgteYefrVqavngag.egpeS

0050432 (Phosphotyrosine protein) phosphatases II 1696-1998 3.1e-102 337.3 In-house 23-304 (308) alignment
Range on Protein: 1696-1998
Range on HMM: 23-304/308.0
VGAIPIKHFPKHVADLHASSGFTEEFETLKEFYQevqsctvdlGITADSSNHPDNKHKNRYINIVAYDHSRVKLaqlaekdGKLTDYINANYVDGY--NR
.  ...... |.. ... .... ||||.| ...           .. .....|.||.|||| .|..||||||||       .. .|||||.|||||  ..
slklsvldllkllekaldlglleeefeellsvkp.........lleysvallpenkdkNrykdilpydhsRVkl.......degsdYInAsyvdgysskl

PKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAD---GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKikkgsqkgRPSGRV
|...||.||||..| ||||||.||.||.||||.|.|||.|| ||.|||| .   ||.|||.| || .|..||..||||...|.|..         .  |.
prkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlg........dgesrt

VTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHavGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLV
||..||| |||.|||..  ..|.|....    ..  ||.|||||||||||||.|.|| .|.|...||.|..|. .|..|.||.. |||.|||.|....|.
vthfhytnWpdhgvPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyrall

EAILSKET
| ...|.|
eylklklt

subfamily_Ptp69D_pd Subfamily Ptp69D 1697-2000 3e-88 290.9 In-house 2-293 (307) alignment
Range on Protein: 1697-2000
Range on HMM: 2-293/307.0
GAIPIKHFPKHVADLHASS--GFTEEFETLKEFyqevqscTVDLgiTADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDgkLTDYINANYVDGYNRP
|||.|.  .. .   .  .  |...|.|.|..        ..|.  ..  |.. .|. |||| .|.|.|. ||||...  |.   .|||||... ||.  
gaiaiddleealksrkrdtdfglakeyekLear.......eidk..stkvsekkenalknRyedikafDktRvkLkkingke..dsdYinasfikgykek

KAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQkgrPSGRVVTQY
| .||||.|. .|..||||||.| .|..|||..|| || |.||..||| .   .||. ||.  | .   .|. |.. . ..| . |     .  | |.||
kkfiaaqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgev...edsrkvvqy

HYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAIL
|||.|.|. ||| .  .| .....   ...  .|.||||||||||.|... |||.|||.. | .|.|| . |..||||| |||  |||||..  |.. . 
hytgWkDskvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

SKETEV
  .|..
ygdtde

subfamily_PTPRD_pd Subfamily PTPRD 1698-2043 3.8e-130 430.2 In-house 4-333 (564) alignment
Range on Protein: 1698-2043
Range on HMM: 4-333/564.0
AIPIKHFPKHVADLHASSGFTEEFEtlkefYQEVQSCtvdLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYNRPKAY
.||......||| |.|.|... | |     |.....       | ...|.| ||.|||| ||||||||||.| ..  .  . .|||||...|||...|||
pipvaelkehvaklkansdlkfeee.....ykkieeg...qqftweaankpaNkaKNRyanivaYdhsRVvLskvegd..egsDYINAsfidgyrkrkay

IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKikkgsqkgRPSGRVVTQYHYT
||.||||..| ||||||.||.|...|||.|.|.|||. ||..|||..|.|.||.. || .. . ||.|..|.|.|...|        . . | |.|.|.|
IAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkk........ssesreVrqFhFt

QWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKE
.||| ||||.  ..|...||   ....  ||.|||||||||||||.||.|.||..|..|.||.|....|..|.|||..|||||||.|||....||. . .
sWPdhgvpesatslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgn

TEVLDSHIHAYVNALLIP-GPAGKTKLEKQFQLLS-QSNIQQSDYSAA
|||  ..... .. |       . |.||. || |.  ..|. .....|
tevesenlkqhlqkLaeveedtemtgleleFqrLatakeieleefava

0051299 (Phosphotyrosine protein) phosphatases II 1698-1993 4.8e-102 336.5 In-house 4-286 (288) alignment
Range on Protein: 1698-1993
Range on HMM: 4-286/288.0
AIPIKHFPKHVADLHassgfTEEFETLKEFYQEVQSCTVDlgITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEkdGKLTDYINANYVDGYNRPKAY
.|..... |.|  |.        . .|.| ..|..|...|  .|  ....| |..|||| .|..||||||||  | .     .|||||.|.||||.....
eisveellklvlkll.....angltglleefeellsllpd..ltlsaallpenleknRysdilpydhsRVkLsvldg..vegsdYinAsyidgynlkrkf

IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKgsqkGRPSGRVVTQYHYT
||.||||..| ||||||.||.||.||||.|.|||.||.||.|||| .||..||.. || .|..||..||||.....|... .    |    | ||..|||
IatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlld....gdgesrtvthfhyt

QWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
.|||.|||..  ..|.|.|..  | ..  ||||||||||||||||.|.|| .|.|...||.|......|..|.||...|||.|||.|....|.|..
nwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl

subfamily_PTPRB_pd Subfamily PTPRB 1698-1998 3.8e-100 329.7 In-house 6-290 (293) alignment
Range on Protein: 1698-1998
Range on HMM: 6-290/293.0
AIPIKHFPKHVADLHASS--GFTEEFETLKEFYQEvqsctvdlgITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRPK
 | ...| .||....| |  .|.||.|.||.. ..          . ...... |. |||| ||..|||||||||.|....|  .|||||||..||| |.
piklekfeehvkkmkadsdlrfseeyeelkavgkd.........qavkaaelavnraknrytnilpydhsrvkLaalkdesg..sDYinanyipgynspr

AYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAD-GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNtkikkgsqkgRPSGRVVTQY
 .||.|||| .| .|||||.||.....|||.|.|||||. ||..|||||  .  ||.  || .. ..|  ...|......          . . | |.||
efiatqGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..........ekeerkvrqy

HYTQWPDMGVPEYSLPVLTFVRKAAYA--KRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEA
|.| ||| |||| . ..|.|||.   |  | .. .|.|||||||||||||.| || .||.|..| .|.|||.. ..|..||.|||||.||.|||..... 
hftsWpdhgvPektktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldl

ILSKET
. .||.
lrkkee

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1698-2033 4e-59 195.0 In-house 3-277 (392) alignment
Range on Protein: 1698-2033
Range on HMM: 3-277/392.0
AIPIKHFPKHVADLHASSGFTEEFETLKEfyQEVQSCTVdlgitadsSNHPDNKHKNRYINIVAYDHSRVKLAQLaeKDGKLTDYINANYVDGYNRPKAY
 ||. .||  | . . |. |.|||  | .   ..   ||        .....|..|||| ||. || .||||  .   |   .||.|| |.....  |||
pipvaqfpafveknrhsalffeefhdlpg..pdiypqtv........aqkeinlkknryknilpydsarvklevi..ddipdsdylnasyipsfdnekay

IAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGrrkcdqywpadgseeygnflvtqksvqvlayytvrnftlrntkikkgsqKGRpSGRVVTQYHYT
||.|||  .. .|||||....||  |.|.|.| |                                                   ||  . | |.|.|.|
iasqgpnaaslddfwrmvfqenvttiamvtklkegd.................................................kgd.dartvaqfhft

QWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKE
.||| .||...  .| |...      .   |...||||||||||  | .||.. . ..   |..| |.  || .| |.|||.||| ||. ...| .| ..
ewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrn

TEVLDSHIHAYVNALLIPGP-AGKTKLEKQFQLLSQS
| .   |.  ... |   .   ...|  |.|. |  |
tlipvvhftdhlqdlstssdGdvrskqlkefrslkas

subfamily_PTPRG_pd Subfamily PTPRG 1699-2010 2.2e-151 499.9 In-house 1-304 (563) alignment
Range on Protein: 1699-2010
Range on HMM: 1-304/563.0
IPIKHFPKHVADLHASS--GFTEEFEtlkefyqEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLtDYINANYVDGYNRPKA
.|.|.| ||||.|||..  ||.||||       ..||.|..  ..|..|..|.||.||||.||||||.|||||..|..|..|| |||||||.|||.. ||
vpvkefakhvaslhadgdigfseefe.......alqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkkl.DYinAnyidGyqkska

YIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQkgRPSGRVVTQYHY
.||.|||||.|..||||||||.||..|||||||||.||||||.|||.|.||.||.. ||... .|||.||||.....|.|.||..|  . . ..|.||||
fiatqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkq..cdteklvrqyhy

TQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
|.|||.||||.|||||.||.|...|.....||.||||||||||||||||||..|.|||.| .||.||||||||.|||.||||||||.|.||.|.|||.||
tkWPdhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiask

ETEVLDSHIHAYVN
|||.|......  |
etellaeqveelkn

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1699-2010 6.5e-110 362.1 In-house 2-297 (318) alignment
Range on Protein: 1699-2010
Range on HMM: 2-297/318.0
IPIKHFPKHVADLHAsSGFTEefetLKEFYQEVQSCTVDlgITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRPKAYI
|..... .||. |.. || ..    |.| |.... ..    .|.  |..| ||.||||.||.||||.|||| .|... |  .|||||||.|||.| ||||
isvedleshvrrlre.sGell....lseeyerlsrseet..vtslkslepvnkaknryanilaydhtrvkLqmlegeeg..sDyinanyidGyrrkkayi

AAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKkgsqkgrpSGRVVTQYHYTQ
|||.||  | ||||||.|| |  ||||.|...|.|..|...||| .||..||.  |. |.   |..|..|.|....|. .        . |.| |||||.
aaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteee........esrqvrqyhyts

WPDMGVPEYSLPVLTFVRKAAYAK-RHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKE
||| |||| .  .| .||.. .|. .. .||.||||||||||||..|..|..|..|..|..|..|.. |..|.||| .||||.||.||.|.|.||. | .
WpdegvpesgaslldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgd

TEVLDSHIHAYVN
|||  |.... ..
tevdasdlrsrir

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1699-2011 8.9e-97 319.0 In-house 5-301 (319) alignment
Range on Protein: 1699-2011
Range on HMM: 5-301/319.0
IPIKHFPKHVADLHAssgfTEEfETLKEFYQEVQSCTVDlgiTADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRPKAYI
|..... ...  |..    | |  .|.. .....  . |   | ||.....||.|||| ||.|||..||.|..| ...|  .|||||...|||.. ...|
ievqeLkerlkalas....tge.tllekefkllkeavnd...tfdsaskeenkkknryqnilaydrtrvvlseldgveg..sdyinasfidgyqerekfi

AAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLrNTkikKGSQK-GrpsgRVVTQYHYT
|.|.||. | ||||||.||... ..||.|.||||.. |. .|||    ||||...|| .. . |. | .|...| |.   | |.       | |....||
atqaPlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nk...kssevet....Revkhfqyt

QWPDMGVPEYSLPVLTFVRKAAYAKRH-AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
.||| .|||... .| .... . ....   ||.|||||||||||||.|||| ||.....||....| . ...| ||| .||..||| ||...|.||. . 
eWpdhdvPekatslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag

ETEVLDSHIHAYVNA
.||.   ...  . .
dteievqdlrdrlkq

0043336 (Phosphotyrosine protein) phosphatases II 1699-1991 1.4e-91 302.1 In-house 2-275 (278) alignment
Range on Protein: 1699-1991
Range on HMM: 2-275/278.0
IPIKHFPKHVADLHASSGFTeefetLKEFYQEVQSCTVdlgITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRPKAYI
|..|...|....|....  .     |.. ..|..|...   .| . ...|.||.|||| .|..||||||||  | .  .  .|||||.||||||.|...|
isvkdllkallelllnlktl.....lllefeellsfkl...dtysiallpenkdknrykdilpydhsrvklsllggdld..sdYinAsyvdgynvprkfi

AAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPaDGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNtkikkgsqKGRPSGRVVTQYHYTQ
|.||||..| ||||||.||..|..|||.|.|||.|| ||.|||| .||..||.| || .....|..||||.... |        .| .  | ||.|||. 
atqgPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn........lgdgesrtvthyhylg

WPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVE
|||.||||   ..| |....  | ..  |||.||||||||||||.|.|. .|.|...||.|...  .|..|.||   |||..||.|... | |
wpdhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1699-2010 2.9e-87 288.0 In-house 11-308 (319) alignment
Range on Protein: 1699-2010
Range on HMM: 11-308/319.0
IPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQSCTVDLgITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRPKAYI
. ...|| .  .|   | | ..   |.  .. .   .|.|  . . .| ..|| |||.|||.|.|...||| .|  ...  .||||| .|.|| |.. ||
vavpdfpayyqqlsnksdfdddltklevefrracklgvnl.adqtfanldqnkdknriinilafdknvvklerliGeef..sdyinasfvtGyqrkdkyi

AAQGPLKSTAEDFWRMIWEHNVEVIVMITnlvekgRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNtkikKGSQKGRpsgRVVTQYHYTQ
||||||. | .||||||||.|.  ||..|      . || |||| .. .....| |  .||.  | |.||.. | .    .| .|.    | .||.|.  
aaqGPldntladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielse....dgkekdi...rkitqfhflG

WPDMGVPEYSLPVLTFVRK--AAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
|||.|||.|. .....|.|      | .   ..||||||||||||.||||| .|.....|  |... |.. .| ||| |||   || ||. .|.|  |  
wpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfg

ETEVLDSHIHAYVN
 ..|    . ||..
hsdvampdfpayle

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1699-1997 1.3e-73 242.4 In-house 2-287 (290) alignment
Range on Protein: 1699-1997
Range on HMM: 2-287/290.0
IPIKHFPKHVADLHAS--SGFTEEFETLKEFYQEvqsCTVDLGITadssnhPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKA
||...| ..||  ||   .|| ..|..|. . .|    ||  |.|      ..||..||. ||| ||  |. | .....     .|||| |..||.  |.
ipvdkfgefvanghakgnegfrnqfkmldsgese...htvtvglt......ssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkq

YIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKkGSQkgrpsgRVVTQYHY
|||.|||...|. |||..||...| .|||.|| .|.|. || ||||. ....||.| ..  . ..| .|. |.. ..|.. . |..      . ||||. 
yiatqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gak......qsvtqyqi

TQWPDMG-VPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS
| |.. | |....  .|.. .     ...  ...|||||..|||........  ... . || ...|  ||. |.|.  .|||..|| .|.. ..... |
tnwdstgkvtnpqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

KE
 |
fe

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1699-1999 1.3e-72 239.3 In-house 2-284 (287) alignment
Range on Protein: 1699-1999
Range on HMM: 2-284/287.0
IPIKHFPKHVADLHAS--SGFTEEFETLKEFYQEVQSCTVDLgiTadssnhPDNKHKNRYINIVAYDHSRVKLAqlaekdGKLTDYINANYVDGYNRPKA
||...| . ||. ||    ||.. | .|..  |. .. |...  .      ..||.|||. .|. .|  || |       |.  ||||| ..|||.  ||
ipvekfgefvakghakgnegfknqftvleqvtqredevthni..a......sqnkdknRltqilvpdnyrvllk......gehpdyinavfidgykekka

YIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKiKKGSQkgrpsgRVVTQYHY
.|.|..|. .|| .||..|...||..|||.... |. ...| |||| . |  .|.. ..  . .| | |..|.. ..|.. |.|..      . |.||..
fiiaesPmfntarnfWkliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknkn.kagdk......qqvkqyqi

TQWPDMG-VPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS
|.|.. | |.|.   .| . ..    .... ...|||||..|||.....  .  ... . ||....|  ||. | |.   ||| ||| || | ..| . |
tnWdstgkvtepqtillvieemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds

KETE
 || 
fety

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1699-2028 2.9e-71 234.9 In-house 3-313 (315) alignment
Range on Protein: 1699-2028
Range on HMM: 3-313/315.0
IPIKHFPKHVADLHASSGFTEEFETLKEFYQEVQsctvdlgitaDSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYNRPKAYI
||. .||  |   . .. |.|||  | .     |           .. ...| .|||| ||. .|..||||  . ..     ||||| |. ...  ||||
ipvaqfpafvnknrhtalfseefhdlpdPdiyrq..........rvaretinfkknryknilPldsarvklevidds..Pdsdyinasyiksvdddkayi

AAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA--DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKikkgsQKgrpsgRVVTQYHY
|.|||||.. .|||||.....|  |||.|.. |  . || ||||     | |.|.. |.  |..  .  ..|....|...     ..     | |||...
asqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarklvtrkse.....es.....rtvtqfqf

TQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
|.||| ||.. .  .| ....    ...   ...|||||||||||  | .|....||... .|..| |.| .|..| |||||||.| ||.|.. | .| .
tewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwr

ETEVLDSHIHAYVNALLIP-GPAGKTKLEKQFQ
.| .|  |.  ... |    . .|..|. |.|.
ntlilvihftdhlqdlhtsvdgsgrskmtkefe

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1702-2012 1.3e-89 295.4 In-house 7-302 (305) alignment
Range on Protein: 1702-2012
Range on HMM: 7-302/305.0
KHFPKHVADLHASS--GFTEEFETLkefYQEvqsctvdlGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDgkLTDYINANYVDGYNRPKAYIA
... ... . .. |  |. .....|   |.|        . . |  ..  ||.|||. .|. .|..|..|..  ..|   .|||||.|||||.| |.||.
ddlaayikearvysdkgleaqyksl...yee........eesidvgkkeankaknrlkeitlldddriiltekesld..dsdyinasyvdgykrkkkyiv

AQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSE--EYGNFLVTQKSVQVLAYYTVRNFTLRNTKIkkgsqkgRPSGRVVTQYHYT
||||||.| .||||.|.|  |..|||.|.||| |. || ||||   .|  |.|.| |. || .  . |. |.... . .           .|.|.||. |
aqgPlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiede.......dkesrtvlqyqlt

QWPDMGVPEYSLPVLTFVRKAAYAKRHAVG-PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
.||| |||...  .|.....   ....  | |..|||||||||||..|..| .|.....|..|..|. ||..||.| ..||| .||||.|| | | | . 
dWPdhGvpqfatsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcg

ETEVLDSHIHAYVNAL
.|... | ..| || |
dtsiigsnlrarvnkl

subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 1703-1802 5.9e-14 46.0 In-house 9-95 (95) alignment
Range on Protein: 1703-1802
Range on HMM: 9-95/95.0
HFPKHVADLHASSGfteefetlKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQlaEKDgklTDYINANYVDGYNRPKAYIAAQG
 |  || ..|. |         .|| .|..| ..  | .        |  |||..||. || .|| |.    .|   .||||| .|||| | ..||||||
vfhshvlemhsnsd........qefdnefksismtsgapytvgsseanipknrflnifpydatrvvltt..krd...sdyinacfvdgyarkncyiaaqg





subfamily_PTPRK_pd Subfamily PTPRK 1706-2028 2.1e-88 291.2 In-house 11-313 (314) alignment
Range on Protein: 1706-2028
Range on HMM: 11-313/314.0
KHVADLHA--SSGFTEEFETLKEFyqevqsctvdlgitADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYNRPKAYIAAQGP
...| |..  . || ||.|.| |                |.... .|..|||. .|.|||.|||.| .. .     .|||||...|.|.||.|.|..|||
qsiallkraegygfkeeyeslfeg..............wdaakkdenreknrsgdilaydrsrvflitidgd..pssdyinaalidsykrpaafivtqgP

LKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEeYGNFLVTQKSVQVLAYYTVRNFTLRNtkikkgSQKGRPSGRVVTQYHYTQWPDMG
|..| .||||.....|   |||.|.|||.|| || .||| |..  ||.. |.  ....|| . || |....      ...|    |.| |.....||| .
lqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtev.ygdikvelvetellaelvvrifrvek......largqeeirevrqfqflgWpdhd

VPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDS
|| .   .|..||.    . .  |..||||||| |||||.|..|..|. |..||.|..|   | .||..  .|.|||||.||.| ..|| |  || .  |
vPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvs

HIHA-YVNALLIPGPAGKTKLEKQFQ
...| |.... .   .  ..|...||
efkalylesirldpqtnssqlkeefq

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1708-1993 1.3e-61 202.9 In-house 9-293 (301) alignment
Range on Protein: 1708-1993
Range on HMM: 9-293/301.0
VADLHASSgFTEEFETLKEfyQEVQSCTVDLgitadssnHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKST
||  |. . | |....|||  .| .|||| |        . .||. ||. ||. ||. |. |..  . | . ..||||.|.|||.. |..||||||.|.|
vaakhsnk.feeqykelke..gedksctvgl........seenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkkt

AEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA--DGSEEYGNFLVTQKSVQVLAYYTVRNFTLR------NTKIKKGSQ----KgrpSGRVVTQYH
  ||||.||.. .  |||.||| |. . || ||||     |||.|.| || .. ||.  ...|.....      |..|..  .    |   |.. |.|..
lvdfWrliwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk...sswdvlqlq

YTQWPDMGV-PEYSLpVLTFVRKAAYA-KRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
 |.||. || .|.   ||  . .  .. ..   ||||||||..|.|.|.|. ..  | | . || |..|.  | .| ..   |.| |||..|.| . . .
vtdWpqdGvvreprt.vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmyl





subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1708-1990 3.9e-53 175.1 In-house 3-274 (287) alignment
Range on Protein: 1708-1990
Range on HMM: 3-274/287.0
VADLHASSGFTEEFETLKEFYqevQSCTVDLGITADSSNhpdnKHKNRYINIVAYDHSRVKLAQLAEKdGklTDYINANYVDGYNRPKAYIAAQGPLKST
|.....     .|...|||     .| |. .  . .  .     .|||| ... .|..|| |.. .|. |  .|||||||| .|.. .|.||||||. .|
veerrvkddvdkevdalkeds...esstatfkaaeelaa....vkknryadvlPiddtrvllsaegel.G..sdyinanyvasytddeafiaaqgPiaat

AEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADgseeYGNFLVTQKSVQVLAYYTV-RNFTLRNTKIKKGSqkGRpSGRVVTQYHYTQWPDMGVPE
  ||||...|... .....|  ||..| || .|||          .|   || .| |     ... |  .. .    .|   ||| |... .||| ... 
vrdfwravletrsasvitmtreveearlkcykywPer....evPmrvGGysvvlldydikePeygvralrlidle..tr.earvvkqldllswPdkvlaP

YSLPVLTFVRKA---AYAKRH--AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLV
 .. .. || .      ..|    |||.|||...|.||.|... .  .... .  | |..   . ..| .|. |||.  |. .. ..||
tavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv

0040438 (Phosphotyrosine protein) phosphatases II 1710-2020 4.1e-98 323.8 In-house 11-303 (317) alignment
Range on Protein: 1710-2020
Range on HMM: 11-303/317.0
DLHASSGfteefETLKEFYQEVQSCTVDlgiTADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEkdGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAE
||..|.        |.|......|...|   | . ...|.||.|||| .|. ||||||||  | .     .|||||.||||.|.....||.||||..| |
dllksdf.....talleefedllslkld...tysvaelpenkdknrypdilpydhsRVkLsplgg..dldsdYInAsyvdgpnlkrkfIatqgPlpntve

DFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTkikkgsqkGRPSGRVVTQYHYTQWPDMGVPEYSL
|||||.||..|.||||.|.|.|.||.||.|||| ... .||.| || .|...||..|.|.... ..        | .  | ||..||| |||.|||..  
dFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl........gdsesrtvthfhytgWpdhgvppspd

PVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYV
..| |....  | ..  |||.||||||||||||.|... ||.|...||.|...  .|..|.||.. |||.|||.|..| | | .. |.| . .|. . ..
llldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkl

NALLIPGPAGK
  |||| . ..
lklliplaldd

subfamily_PTPN6_pd Subfamily PTPN6 1710-1993 2.6e-79 261.4 In-house 21-297 (306) alignment
Range on Protein: 1710-1993
Range on HMM: 21-297/306.0
DLHASSGFTEEFETLKEfyQEvqsctVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAqlaEKDGKLTDYINANYVDG--YNRPKAYIAAQGPLKST
.  . .||.||||.|..  .|     .   .. . ...|.||.|||| ||. .||.||.|.   |.. . .|||||||...   .  |.|||.|| |..|
eslekagfeeefeelqq..ee.....akkllsrkegakpenkeknryknilPfDhtrvilk...epsvpgsdyinanyikkevkgsdksyiatqgclett

AEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGS-EEYGNFLVTQKSVQVLAYYTVRNFTLRNTkikkgsqKGRPSGRVVTQYHYTQWPDMGVPE
 .|||||.|. | .||||.|. ||.|. || .|||.  . ||||.  ||. | . ||.|..|.... ..       |   . | | |||...||| |||.
vsdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskk.......kkkkeerevfqyhfksWPdhgvpk

YSLPVLTFVRKAAYAKRHA----VGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGT---VNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
    || |...    ...      ||.|||||||.|||||.||.| .|..|...|.   ..|  . | .|.||. |||||.|| |.. .. . |
dpgavLdfledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi

0039614 (Phosphotyrosine protein) phosphatases II 1711-1996 4.9e-92 303.8 In-house 28-292 (297) alignment
Range on Protein: 1711-1996
Range on HMM: 28-292/297.0
LHASSGFTEEFETLKEFYQevqsctvDlgitADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGkLTDYINANYVDGYNR-PKAYIAAQGPLKSTAE
.  .... .|||.|...         |       ...| ||.||||..|..||||||||  . . |   .|||||.|||||.. ....||.||||..| |
ansktllllefeellslkp.......d....ysiallpenkdknrykdilpydhsrvklkpedgvdl.dsdYinAsyvdgydlltrkfIatqgPlpetve

DFWRMIWEHNVEVIVMITNLVEKGRrKCDQYWPADGSeEYGNFLVTQKSVQVLAYYTVRNFTLRNtkikkG--SqkgrpsgRVVTQYHYTQWPDMGVPEY
|||||.||..|.||||.|.|||.|| ||.|||| .|. .||.| || ..|..|..||||.....|     .  |       | ||...|| |||.|||..
dFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkvehldgytvrtlevtn.....nges.......rtvthfqytgwpdhgvpps

SLPVLTFVRKAAYAKRH--AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
.  .| |....  | ..    |||.||||||||||||.|... ||.|...||.|...  .|..|.||.. |||..||.|..| |.| .. |
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1712-1993 1.8e-88 291.3 In-house 18-279 (288) alignment
Range on Protein: 1712-1993
Range on HMM: 18-279/288.0
HASSGFTEEFETLkefyqevqsCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRPKAYIAAQGPLKSTAEDF
.. .||.||...|          ...   . . .... |..|||| ||..||. |||| .| |..|  .|||||.|.||... |.|||.|||| .| .||
rnrtgfseeynsL.........aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeag..aDYinasyidgekkkkkyiatqgPladtvndf

WRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGS-EEYGNFLVTQKSVQVLAYYTVRNFTLRntkikkgsQ---KgrpsgRVVTQYHYTQWPDMGVPEY
|....|.... |||.|.|||.|..||..|||...  ..||.. || .... |  ...|.. |         .   .     . .|||.|. |||.|||| 
WelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle........kkkte.....leitqyqylaWpdhgvPes

SLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
. |.| ..|.   |.   .||..||||||||||||.|.|| .......| .....|.....| ||. ||||..||.||...|.. |
kapllellrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllsli

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1712-2000 1.9e-88 291.6 In-house 24-297 (298) alignment
Range on Protein: 1712-2000
Range on HMM: 24-297/298.0
HASSGFTEEFETLKEFYQEVQSCTVDLGitadssNHPDNKHKNRYINIVAYDHSRVKLAQLAekDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDF
.  .|...||..|..  .|... . . .      ..|.||.|||| .|.|.|.||| | .    . . .||||| ....|.. .|.||.|.||..| |||
kkltgyalefqrlnsvsseieeeekeva......rkpenkkkNRyadiialdssRvvLeked..adeesdYiNAsflhaykgrnafiatqaPltetvedF

WRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKikkgsqkgRPSGRVVTQYHYTQWPDMGVPEYSLPV
|||..|.....|||.|||.|... |. .||| .|.|.||.. |. .| .. | ..||.... ..|        . . | | | |.|.||| ||||..  |
WrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkk........eekerevrqlhftsWpdkgvpenatsv

LTFVRKAAYAKRHAV-GPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV
|...||    ...|   ||.|.|||||||.||.|..||.|.....| .| .|  .| .| .|  .||||||||||..   ||. | ..|.
ldllrkvrasqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei

subfamily_PTPN12_pd Subfamily PTPN12 1712-1996 2.7e-78 257.8 In-house 5-280 (290) alignment
Range on Protein: 1712-1996
Range on HMM: 5-280/290.0
HASSGFTEEFETLKEFYQEVQSctvDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRPKAYIAAQGPLKSTAEDF
...  |..||..||.  .. ..   .  ......... |..|||| .|. ||.|||.| .  |..|   ||||||.. | . ...||||||||  | .||
egeeefakefqklkklsekyka...ekvysteagekeenvkknrykDilPydksrvelskieeeeg..sdYinanfikgvegkleyiaaqgPLpktlddf

WRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEE--YGNFLVTQKSVQVLAyytvRNFTLRNTKIKKGSQKgrpsgRVVTQYHYTQWPDMGVPEYSL
||||||.|||..||. ..|| |. ||..|||  | ||  .|.| ||... . .      .|..|  |... ...     |.|.|.|||.||| |||.   
WrmiweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavd....ddflirtLkveaqkes.....rkvyqfhYtaWPDhgvPssak

PVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGT---VNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
..| .....   ...   |.||||||||||||| |..| . .....| .   ...|  . ..| ||. ||||.|||.... ...| . ..
sllelielvrelqesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1713-1994 1.2e-82 272.2 In-house 11-277 (281) alignment
Range on Protein: 1713-1994
Range on HMM: 11-277/281.0
ASS--GFTEEFETLKEfyqevqsctVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQlaEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAED
...  ||.||.|.|..         .... || .|....|..||||.||||||..|||...  ... | |||||||.|.||. .|.|||.|||. .. ..
qndnaGfieeyeklaa.........igvdntataskadenvlknrYsnivaYDatrvkvtp..neenkntDYinanfvpgykgekeyiatqgPvPaslva

FWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADG-SEEYGNFLVTQKSVQVLAYYTVRNFTLrNTkiKkGSQKgrpsgRVVTQYHYTQWPDMGVPEYSL
||.|.||..|..|||.|. .|.|. || .||| |  . .||.. |.... .  | |  |.|.| ..  . ....     | |.| .||.||| |||. . 
fWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.er..e.sget.....reveqlaytaWPdhGvPattk

PVLTFVRKA-AYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHE-GTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAIL
 .| | ..   . ...   |.|.||||||||||||| || .......|  ....   ....| .||..|||  || |.. ....|. 
ellefrkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_PTPN23_pd Subfamily PTPN23 1713-1992 3.6e-55 181.8 In-house 13-279 (288) alignment
Range on Protein: 1713-1992
Range on HMM: 13-279/288.0
ASSGFTEEFETLKEfYQEVQscTVDLGITADSSnhpdNKHKNRYINIVAYDHSRVKLAqlaekdGKLTDYINANYVDGYN-RPKAYIAAQGPLKSTAEDF
  ... ..|. |.. .|. .  . .  |..       . .|||. .|. |||.||||       |.  ||||| .| .       .||.|.||.||. ||
gktaldkkfkeleq.kqdke..arkrsiaiakl....yseknrsrdilPyDhnRvklr......gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDF

WRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADG--SEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKgsqKgrpsgRVVTQYHYTQWPDMGVPEYSL
|.|..|  ..||||...  |.|. |.|.|||.|   ....|.. || |||. . ..  |...|.  . ..   .     . |.  ..|.||..|||.   
WlmvyeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkletldada...v.....ksvshlqltsWpelGvPasPe

PVLTFVRKAAY----AKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQ-HEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEA
 .| |. ..       .|..  |.||||||||||||.. .. . ..... ..| ..|   ....| || . ||..||. |  .  .||
tllqfldevesayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea

0047943 (Phosphotyrosine protein) phosphatases II 1714-1993 1.9e-95 314.7 In-house 11-272 (273) alignment
Range on Protein: 1714-1993
Range on HMM: 11-272/273.0
SSGFTEEFETLKEFYQevqsctvdlGITADSSNHPDNKHKNRYINIVAYDHSRVKLaqlaekDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWR
.... ||||.|....           .|   ...|.||.|||| .|..||||||||      ... .|||||.||||||.....||.||||..| |||||
ltllleefelllslkp.........lltysvallpenkdknrykdilpydhsrvkl......gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwr

MIWEHNVEVIVMITNLVEKGRRKCDQYWPADG---SEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKikkgsqkgRPSGRVVTQYHYTQWPDMGVPEYSLP
|.||.||.||||.|.|||.||.||.|||| .|   |..||.| || .|... ..||||...|.|..         .  |.||..||| |||.|||..  .
mvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlg........tgesrtvthfhytgwpdhgvppsles

VLTFVRKAAYAKRH--AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
.|.|....  | ..    ||||||||||||||||.|.|| .|.|...||.|...  .|..|||| . |||.|||.|....|.| .
llefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl

0045450 (Phosphotyrosine protein) phosphatases II 1717-1994 1.5e-93 309.1 In-house 22-305 (307) alignment
Range on Protein: 1717-1994
Range on HMM: 22-305/307.0
FTEEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdGKLTDYINANYV--------DGYNRPKAYIAAQGPLKSTA
  . .. |.. .....|.||.| .. .....| ||.|||| .|..|||.||||  | ..  . .|||||.||        |||......||.||||..| 
lldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgs.ledsdYiNAsyvrvpllllldgydlkrkfIatqgPlpetv

EDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSE-EYGNFLVTQKSVQVLAYYTVRNFTLRNTkikkgsqKGRPSGRVVTQYHYTQWPDMGVPEY
||||||.||..|.||||.|.|||.||.||.|||| .|.| .|||| || .|...|..||||.... ..       .|   .| ||..||| |||.|||..
edFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.......dgtgesrtvthfhytgwpdhgvpps

SLPVLTFVRKAAYAKRH--AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGT---VNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAIL
  ..| |....  | ..    |||.||||||||||||.|... ||.|...|||   |...  .|..|.||   ||..|||.|... | | .|
feelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallelll

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1717-1991 3.3e-49 162.3 In-house 8-257 (267) alignment
Range on Protein: 1717-1991
Range on HMM: 8-257/267.0
FTEEFETLKEFYQEVQSCTVdlgitadsSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgkltdYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIW
. .||| .|.  .. . ..         |   .|. .||. . . ||..|| | .  |       |||| ||.||.. .|.|. |.||| |  ||. .| 
iekefelikkisdtsstisq........siaeknqernrlddnlpyddtrvilrtkeee......yinasyvegyktknafivtqdplkntitdfltvih

EHNVEVIVMITNLvekGRRKCDQYWPAD--GSEEYGNFLVTQKSVQVLAYYTVrnFTLrNTKIKKGsqkgrpSGRVVTQYHYTQWPD-MGVPEYSLPVLT
...| |||..|.    .  .  ..||     ...| .. | .   .    | .   || . |.|.       | . || |.| .|        |  |.. 
dqkvpvivlltkv...ftdnirlfwPPkmgqakkyqdltvehslekeendyqi..itl.elkfkne......sahnvtlyyykkwnintnnkpylkplfg

FVRKAAYakRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVE
 . |       .  |.||.||.||||.||..|.||.|.....||...|| ||..|||||  ||.| |.|..||..|.|
ilaknql..engnrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae

DSPc_SM00195 1719-1993 4.5e-91 300.2 In-house 4-262 (263) alignment
Range on Protein: 1719-1993
Range on HMM: 4-262/263.0
EEFETLKEFYQEVqsctvdlgiTADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEH
||||.|.| ...          . ...... ||.|||| ||. |||.|||| .  .|  . .|||||||..|.|..|.|||.||||.|| ||||||.||.
eefekleestspk.........etteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvwee

NVEVIVMITNLVEKGRRKCDQYWPAD--GSEEYGNFLVTQKSVQVLA-YYTVRNFTLRNTKIkkgsqkgrPSGRVVTQYHYTQWPDMGVPEYSLPVLTFV
.|..|||.|. .|.|..|||.||| .  |.|..|.. |. ..|.     ...|...|....            | ||||.|..||| |||.   .|| ..
kvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk........eetrkvtqyqyknWpdhgvpdstksvlell

RKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
|..   |..  ||.|||||||||||||....|..|.....| .|.||  .|..|.||  .|||.||| ||.....|.|
ravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 1719-1993 4.5e-91 300.2 In-house 4-262 (263) alignment
Range on Protein: 1719-1993
Range on HMM: 4-262/263.0
EEFETLKEFYQEVqsctvdlgiTADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEH
||||.|.| ...          . ...... ||.|||| ||. |||.|||| .  .|  . .|||||||..|.|..|.|||.||||.|| ||||||.||.
eefekleestspk.........etteaekkknksknRyknilpydhtrVklkkeekk..egsdYINAnyikgankkkkyIatQgPlpstvedFWrmvwee

NVEVIVMITNLVEKGRRKCDQYWPAD--GSEEYGNFLVTQKSVQVLA-YYTVRNFTLRNTKIkkgsqkgrPSGRVVTQYHYTQWPDMGVPEYSLPVLTFV
.|..|||.|. .|.|..|||.||| .  |.|..|.. |. ..|.     ...|...|....            | ||||.|..||| |||.   .|| ..
kvkiivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk........eetrkvtqyqyknWpdhgvpdstksvlell

RKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
|..   |..  ||.|||||||||||||....|..|.....| .|.||  .|..|.||  .|||.||| ||.....|.|
ravkkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1719-2000 1.4e-64 213.2 In-house 17-286 (439) alignment
Range on Protein: 1719-2000
Range on HMM: 17-286/439.0
EEFETLKEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEH
.. | .|| .....|   |    |    .  .. |||| ...|.||.|| | ..       . ||||||..||  .| |||.||| | |..||||...|.
nkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgv..phshyinanyikGyyddklyiatqgpkkettddfwrlviek

NVEVIVMITNLVEKGRrkcdqYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKkgSQKGrpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKA
..  |||.|||||  .     |||.|.   ||.  |       |  |..| | . | . .  ..|     | | |.||. |||  ||  .  || |.|  
ktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdt..teke....rtvlqfhyiawpdknvpaqashvldflrai

AYAK-RHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV
  |. .. .|||||||||||||||| | ||  |.|.. |  |.| | .| .| ||. .||.  |||||.....| |   .. |
nsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiav

subfamily_PTPRA_pd Subfamily PTPRA 1721-2000 2.4e-92 304.4 In-house 31-302 (330) alignment
Range on Protein: 1721-2000
Range on HMM: 31-302/330.0
FETLKEFYQEVQSCTVDlgITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNV
 . ..| .. . .....   | . ... .||.|||..||. ||.||| |...  .  . .||||| ..|||.. . .||||||.. | |||||||||.. 
nklfreefnalPagpiq..atlelaskeenkeknrvvnilPydfsrvilsvkeGv..eesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqks

EVIVMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRntKIkkGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAY
  |||.|.| |. . || |||| .|.  |||  |. . ..||  ||||.| ..  ..  . .. . . |.|.|.|.| |||.|||  .  .| ...|   
ativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvq..ql..pdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkk

AKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV
 ..   ||.|||||||||||||.||||..|.... |. |..|.|.|..| ||  .|||.|||.||. .| |  |  .||.
lnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdtel

0036941 (Phosphotyrosine protein) phosphatases II 1723-2003 4.1e-97 320.3 In-house 14-287 (297) alignment
Range on Protein: 1723-2003
Range on HMM: 14-287/297.0
TLKEFYQEVQSCTVdlGITADSSNHPDNKHKNRYINIVAYDHSRVKLaqlaekDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEV
 |.. ..|.... .   .. . .. |.|..|||| .|..|||.||||      |.  .|||||.|||||......||.||||..| ||||||.||.||.|
lllkefeellplll..lgslsvallpenleknRykdilpydhtRVkl......ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtv

IVMITNLVEKGRRKCDQYWPAD--GSEEYGNFLVTQKSVQV--LAYYTVRNFTLRNTkikkgsqkGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKA
|||.|.|||.|| ||.|||| .  .| .||.| || .||.|  |..||.|.... .|        | .  |.||..||| |||.||||.  ..| |....
Ivmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt........gngesrtvthfhytgwpdhgvpespaslldfielv

AYAKRH--AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQ---HEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDS
  . ..    |||.|||||||||.||.|..| ||||..   .||.|.|. ..|..|.||.  |||.|||.|....| | ...|.| . ..
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepll

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1723-1991 8e-44 144.4 In-house 9-267 (281) alignment
Range on Protein: 1723-1991
Range on HMM: 9-267/281.0
TLKEFYQEVQSCTVDLGI-TADSSNHPDNKHKNRYINIVAYDHSRVKLAQ-LAEKdgKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNV
|| .| ||.     |     .   |.| |..||||.|| . | |||.|   . .|  . |||| |||.      . || .||| | |  |||||||. | 
tlddfkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnk..nstdyihanyirspflkrgyiltqgpkketradfwrmiwqent

EVIVMITNLVEKGRRKCDQYWPADGseeYGNFLVTQKSVQVlAYYTVrNFTLRNTKIKKgSQKGrpSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAay
  |||. ...|  | || .|.| .    .  . . . ||.     || | .|  |...  | .|    |..|.. . .|||  ||| |  .|  .||   
taivmlcqfletnrekcaeyfprna...hcclqfdklsvsy.edstv.nkslvttrlnl.syeg..etrlithwlwkewpdwqvpessevmlkilrki..

akRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTV-NIFGFLKHIRS-QRNYLVQTEEQYVFIHDTLVE
  |    | |.||||||||.|| . ..  || |.   |. .|   . |.|   |   ||| .||..|   |..
..rarstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld

subfamily_PTPN9_pd Subfamily PTPN9 1724-1996 4e-80 264.0 In-house 18-293 (297) alignment
Range on Protein: 1724-1996
Range on HMM: 18-293/297.0
LKEFYQEVQSCTVDlGiTADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDgkLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVI
|.. |.|... .|  | |.. |... | .|||| ... ||..||.||.. |..   .||||||.||||...||.||.||||| | .|||||.||..| ||
lskeyaeirnepve.G.tflasklranleknrytdvlcydetrvvlakvdede..asdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvi

VMITNLVEKGRRKCDQYWP--ADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKgsQkgrpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAY-
||.| .||.||.|| ||||   . |.|.|.. |.. .|..   |.|| ....|.| ..  .      | || . .. ||| |||. .  .| ...|.   
vmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvktee..s......rkvthfqflsWPdyGvPssaaslldvlekvrek

-----------AKRHAVG-PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
            | |. | |.|||||||.|||||.| ||  |......|||...  .|..|.|| . .||.|||.| . ...|  |..
qalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleyalel

subfamily_PTPN1_pd Subfamily PTPN1 1724-1994 1.2e-63 209.5 In-house 8-272 (290) alignment
Range on Protein: 1724-1994
Range on HMM: 8-272/290.0
LKEFYQEVQSCTVDLgiTADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEkdgkltDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVI
 ||.|....  . |.  .. ....| |. .||| ..  |||||.|| .         |||||. |.  .  . || .|||| .|.. ||.|.||..   .
ykeiyldirkeasdf..ptreaklpenrnlnryrdvspydhsrikleradn......dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskav

VMITNLVEKGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKgsqKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAA--YA
||. ..|||.. || |||| . .|.   .  |. .|....  . ...|.|  ....   .     |.....|||.|||.||||     | |. |     .
vmlnkvvekeqikcaqywPqgeeekellledtklkvkliseerksyytvrllelen...lktqetreilhfhyttwpdfgvpespaaflkflfkvresGs

KRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGT---VNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAIL
  . |||.|.|||||.||.||....|..| .|....    |.|   | ..|..|  |.|| .|  | . ...| . 
lssdvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1724-1997 9.7e-23 75.0 In-house 28-289 (302) alignment
Range on Protein: 1724-1997
Range on HMM: 28-289/302.0
LKEFYQEVQSCTVDLGItadSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEkdgkltDYINANYVDGYNRPKAYIAAQGPLKSTA---EDFWRMIWEHNV
.|. ......  |||      . . .| .||.  .. ..|. .|||.. ..      .|.||  |.  .  .  | || | ....   |.||||......
vkkefkkidtmkvdlek...Ckafkknlkknqsedvpildsnlvkleaepd......syvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqeki

EVIVMITNLVEKGRrKCDQYWP--ADGSEEYGNFLVTQKSVQVLAYYTvRNFTLRNtkIKkgsqKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKA
  .|..    |  .   ....|  ..  .|||.. | .. |.     .  ....    .     .|     ... |. |.|..  ||.    . . . | 
vsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEv..lP....egcsnsvlanvyvltnWkqkkvpvkyaeliktaakv

AYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKE
   | .|  ..|.    |.|| |. ..|   ....|..  .||   .| |||||   |.. .|||... .|.  |. | 
fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkkv

0046845 (Phosphotyrosine protein) phosphatases II 1725-1998 8e-97 319.3 In-house 3-279 (284) alignment
Range on Protein: 1725-1998
Range on HMM: 3-279/284.0
KEFYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEkDGKLTDYINANYVDGY-----NRPKAYIAAQGPLKSTAEDFWRMIWEHN
.| ..|..|.||.| .. . ...| |..|||| .|..||||||||  | . | . .|||||.|||||     ...|..||.||||..| ||||||.||.|
eeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldg.dledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

VEVIVMITNLVEKGRRKCDQYWPADG-SEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIkkgsqkgRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKA
|.||||.|.|||.|| ||.|||| .| . .||.| || .|..|  .||||...|.|...           | ||..|||.|||.|||... ..|.|.|..
vrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgy.......tgesrtvthfhytswpdhgvppspedlleflrlv

AYAKR--HAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEG---TVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKET
  . .  .  ||.|||||||||||||.|.|| .|.|...||   .|.... .|..|.||.. |||.|||.|....|.|....| |
rellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklklt

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1726-2004 1.2e-68 226.4 In-house 26-295 (297) alignment
Range on Protein: 1726-2004
Range on HMM: 26-295/297.0
EFYQEVQSCTVDLGITADSSNHPD-NKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRpkAYIAAQGPLKSTAEDFWRMIWEHNVEVIV
....|   |.    |...   .   | .|.|| ||. || |||||| . ..     ||.|| .| |..    .|. | | |.| .|||.|.....| .||
dvfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpd..sDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstiv

MITNLVEKGRrKCDQYWPADGSEEYGNFLVTQKSVQvlayyTVRNFTLRNTKIKKGSQKGRpsgRVVTQYHYTQWPDMGVPE-----YSLPVLTFVRKAa
|.... |. . || .||. .|. ..|.  |. .||.       . |  |. ...||. | |   ||| ||....|||  |..     . | ... |||  
mlnddnerdk.kcaryWsdkgvttfGdvsvvllsvs.....ereGfikrelevtkgkakar...rvvkqyqfveWPdkaverkdsassllklisevrkd.

YAKrHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSH
. . .| ||..|||.||||||| .. .||.. ....| .|.|||..|..| .| |||||.||| |.. ...||.||..|..  |.
fsq.naegPllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasy

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1727-2027 4.6e-69 228.0 In-house 25-323 (325) alignment
Range on Protein: 1727-2027
Range on HMM: 25-323/325.0
FYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLaeKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEViVMI
| .|..    | ||.   . .|.|| |||. |.||.|.||| |  .  ||   .|||||.|.  . . . ..||| || .| .|.||.. . .  | |..
fahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletk..kddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsv.vvv

TNLVEKGRRKCDQYWPAD--GSEEYGNFLVTQKSVQVLAYYTVRNFTLrntkikKGSQKGRpsGRVVTQYHYTQWPDMGVPEYSLPVLT---F---VRKA
.| ...|  .| .||| .   | ..| . |  .... .. |  | . .      |. .||    | | |...  |.||||...   ...       | . 
lneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldv......kqvkkGe..trsvkqfqlqswddmGvqkrpatlisilqlvkavser

AYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGPA
  |. .| .|..|||||||||||..| | |.|... .|  |.||||.|..| .|  .|.| .||..|...||||..| .|.|  | ..| ...|    | 
vtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslqernpl

-GKTKLEKQF
  | ..||.|
tqklniekef

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1727-2000 3.2e-51 169.2 In-house 21-284 (307) alignment
Range on Protein: 1727-2000
Range on HMM: 21-284/307.0
FYQEVQSCTVDlGITADSSNhpDNKHKNRYINIVAYDHSRVKLaqlaEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMI
 ....   | . |.|... .   | .|||| .. . |..|. .    . ||  .||| |||.    .|| .|.|||||..|  .|| |. ...|| ..|.
efrvlakktpe.gvtveafs..antdknryqdvkcqdkgrivv....kfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesviml

TNLVEKGRRKCDQYWPADGSEEygNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGR--PSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRkaayAKRH
 ...| .. ||.||||..  ..  .  . .     .|   .....  .  |.  . |       | .... ...||| |||.  |  . ..     | | 
ckvielakikceqywpleegqk..lvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlle....avry

AVGPVVVHCSAGVGRTGTYIVLDSMLQ-QIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV
   ||||||||||||.|| . .  . .  |. .   ..  ... .||||.| .||| ||...|  |.|  | .  | 
dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyket

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1727-1791 8.9e-09 29.2 In-house 24-86 (440) alignment
Range on Protein: 1727-1791
Range on HMM: 24-86/440.0
FYQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLaeKDGKLTDYINANYVDGY
| .|       |   .| .. |.|| |||| ||.||||||| | ..  |    .||||| |..| 
fedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleev..kgvpdsdyinasyingi

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1728-2027 1.6e-86 285.1 In-house 27-314 (315) alignment
Range on Protein: 1728-2027
Range on HMM: 27-314/315.0
YQEVQSCTVDLGITADSSNHPDNKHKNRYINIVAYDHSRVKLAqLAEKDGKlTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMIT
 |. .|         | ...  ||.|||||||.|||.|||.|  | |.| . .||.|||..||||... |||||||. .. .||||...|...  |||.|
kqdyesipggqlhpldvakkienkqknryiniiaydksrvqlp.llendph.sdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmlt

NLVEKGRRKCDQYWPADgSEEYGNFLVTQKSVQVLAYYTVRNFtlrntkikkgSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVG
||||. .||...||| .    ||.. ||.|| .|   |||| .          |   .   | | |.||| |||||||.|..|.. ..|..   .  .||
nlvegekrkaekywpdk.kviyGkitvtrkseevnteytvrtl..........svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvg

PVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGP-AGKTKLEKQ
..|||||||||||||.| ||..|.|.. |  .... |.. .|..|  .||. ||| ||.|.|.|...  .| . .       ..|| | | .| | |..|
aivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllapspdtgstllqeq

F
|
f

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1729-1986 2.3e-38 126.7 In-house 30-274 (301) alignment
Range on Protein: 1729-1986
Range on HMM: 30-274/301.0
QEVQSCTVDLGITADSsNHPDNKHKNRYINIVAYDHSRVKLAqlaeKDGKLTDyINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITN
..|.  |.|     .| .   .|.|.|| ..    .. |..     .|||    | ||...   .|. .||.|||||.|.|||| |.  ..|| |||...
envnvttidkdhites.yaylpkdkhryptvPckPstavevi....vdGkrvP.ihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgq

LVEKGRRKCDQYWPADGSEE--YGNFLVTQKSVQVLAYytvRNFTLRNTKIKKGSqkGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAayaKrHAV
 |||  .||..| | . ||.   | | .. |. ...      . . |. ...  .  |. . | || | |..|.| |||.    .  ..  .   | .. 
kvekleekceeylpvkisekldigrfkikiknkeliln...kkiskrtlevedst..gkfatrtvthyqysewtdrgvPkshaelfdlmelv...k.kse

GPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIH
 |.|||||||.||. ..|  . . .... . |...   |||.| .|   |||..|  .. 
kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtnsqlywmt

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1736-2001 8e-59 193.8 In-house 20-274 (283) alignment
Range on Protein: 1736-2001
Range on HMM: 20-274/283.0
V-DLGITADSSNhpDNKHKNRYINIVAYDHSRVKLAQLAEkdgkltDYINANYVD---GYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVE
| ||  . .|..  .||.|||. .||..|  ||.|  ...      ||||| ..     |.. | ||.||.||. |  |||.|......  |||.|.| |
vpdldadiasad..enkrknrnqeivpadqwrvelksesr......dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqe

KGRRKCDQYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTkikkgsqKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVV
  | || |||| .|||.||.| || .       .......||.            |  ... | . .| ..|       .. | .  .  ...  ||.||
dlrikCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvn.......ssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivv

HCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVL
|||.|.|||...| . . ..... |  |..|  .| .| ||  .||| .|| ..|.  .|  |  .|.. 
hCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqia

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1739-2010 2.1e-83 275.1 In-house 14-272 (284) alignment
Range on Protein: 1739-2010
Range on HMM: 14-272/284.0
GITADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITnlvekgRRKCD
| .   .| ..|| |||...|.|.|...||| .|  ...  .||||| .. || |.. |||.||||. | .||||||||.|.  ||..|      . || 
gtdqtfanldqnkdknrighilafdknvvklerliGeef..sdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcs

QYWPADGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNtkikKGSQKGRpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRK--AAYAKRHAVGPVVVHCSAG
|||| .. .....| |  .||.  . |.||.. | .    .| .|.    | ..|.|.  |||.|||.|. .....|.|      | .   ..|||||||
qywplkivikeerfkvkvdsveeseeyvvrdielse....dgkekdi...rkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsag

VGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVN
|||||.||||| .|.....|  |... |.. .| ||| |||   || ||. .|.|  |   ..|    . ||..
vgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayle

subfamily_PTPN3_pd Subfamily PTPN3 1739-1992 3.7e-70 231.0 In-house 30-274 (280) alignment
Range on Protein: 1739-1992
Range on HMM: 30-274/280.0
GITADSSNHPDNKHKNRYINIVAYDHSRVKLAQlaekdgKLTDYINANYVD----GYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGR
|.. . .. |.| .|||| .|..||. |||| .        |||||||||.    . .  . |||.||||..||.|||.|.||.....|||.|.|||.||
glaisaarkpenlsknryrdilpydatrvklke......setdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGr

RKCDQYWPADG-SEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGsqkgrpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHC
 || ||||  . . |||.| |. .. .    | .|...|.... |.         | ..|  |..||| |||. |  .|.||..   ... .  ||||||
vkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkee........rkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhC

SAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEA
|||.|||| .|.|.  |. |...  |..   ....| ||  ||||..|| |. ......
saGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1740-1849 2.6e-14 47.5 In-house 87-186 (244) alignment
Range on Protein: 1740-1849
Range on HMM: 87-186/244.0
ITADSSNhPDNKHKNRYINIVAYDHSRVKLAqlaeKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKgrrkcDQ
.  |. | |.| .|||    . .| .|| |.    |      |||| .|    |   || .| ||  |. |||.|. |  |.|.|..  . |.     |.
vmkdafn.pnnswknregaglpfdfnrvpls....kgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee.....de

YWPADGSEEY
|||     |.
ywpdseplew

subfamily_PTPN13_pd Subfamily PTPN13 1741-1993 1.1e-62 206.8 In-house 28-269 (273) alignment
Range on Protein: 1741-1993
Range on HMM: 28-269/273.0
TADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEkdgkltdYINANYVDGY--NRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCD
|...... .||.|||| |.. ||..|||| . .        ||||...     .    |||.||||  |..|||.|.|| ..|||.|.|. .|||. ||.
tcevgkkkenkdknryrnvlPydetrvklgdegg.......yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkch

QYWPADGSEEygNFLVTQKSVQVLAYYTVRNFTLRNTKIKKgSQKGrpSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRhAVGPVVVHCSAGVG
.|||   ...    .  .  |..| .    .|..|. ..|. |. |    | |.. ....||| |||  ....|.||.. .  ..   ||.|||||||.|
rywPesknkk..lkvsnrlevellkvqkldgfvvralavkd.sesg..esrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivvhcsaGiG

RTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
|.||.|..| .|. |...  ...   ....| ||. .|||..||.|.. ...|..
rsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevl

subfamily_PTPRN_pd Subfamily PTPRN 1741-1992 5.7e-62 204.1 In-house 47-291 (297) alignment
Range on Protein: 1741-1992
Range on HMM: 47-291/297.0
TADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYV-DGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQ
|.. .....| .|||. ....|||||||| . |...   .|||||  . |   |  ||||.|||| ||  |||.|.||. | |||..|.| |.| ..|..
tkevakaeknvkknrskavlpydhsrvklkeeasaek..sdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckr

YWPADGSEEYGNFLVTQKSVQVLA-YYTVRNFTLRNTKIKKgsqkgrpsGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVG
||| .||| |. . |   |  . .  | || | |.| . ..         | |||.|.  ||..|||  . ..| | ||   . |    |.|||||.|.|
ywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtse........trtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGaG

RTGTYIVLDSMLQQIQHE-GTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEA
|||.||..| .|.....    ..|   |.|.| ||. ||.|..|. |.  ...| 
rtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaee

subfamily_PTPN14_pd Subfamily PTPN14 1741-1993 3.4e-57 188.7 In-house 40-296 (300) alignment
Range on Protein: 1741-1993
Range on HMM: 40-296/300.0
TADSSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgkLTDYINANYVDGY--NRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCD
. .... |.|..|||. ... |...||.|.   |.    |.||||  .      . . ||.|||||. | .|||.|.||..|..|||.|.  |.|. |. 
llstaklpenaeknrfkdvlPyednrvelsptken...stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

QYWPADGS----EEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKgsQkgrpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRH---------A
.|.| ..|     |.|.| ||.| ..    .. . ..|.    |.  .      | |    || ||| ||||   . | ....    .|.         .
kyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpske..e......rtvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskes

VGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
  ||.|||||||||||  |. | ... ..|. ...|   |...| || .||||  || |....|.. .
kPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

0049772 (Phosphotyrosine protein) phosphatases II 1741-1994 3.4e-44 147.2 In-house 37-281 (314) alignment
Range on Protein: 1741-1994
Range on HMM: 37-281/314.0
TADSSNHPDNKHKNRYINIVAYDhSRVKLAQLAEKDgklTDYINANYVDGYnrpKAYIAAQGPLKSTAEDF----------WRMI--WEHNVEVIVM---
|   .... |..||||..|. .| .||.|  |  ..   .|||||.||||.   ...||.||||. | .||          |||.  ...|| .|||   
tilvadlflnrdknryldilpad.nrvilpglpvsg...sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrd

------------------ITNLVEKGrrkcdqywpadgseeygnflvtqksvqvlAYYTVRNFTLRNtkikkgsqkgrpS--------GRVVTQYHYTQW
                  ...| ..|                             ...|.... | .            .         | . .|... .
evladelsrLdaAlgKtpllildgng.............................neptaadlellk............eelydpelferlgikylripv

PDMGVP--EYSLPVLTFVRKAayakrHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIqhegTVNIFGFLKHIRSQRN-----YLVQTEEQYVFIHDTLVEA
|| ..|  |. . .| |...|     .. |||.|||.||.|||||..|.. .. .      |..   |...|..|       .... |||.||.. | |.
pDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealley

IL
. 
lk

0045098 (Phosphotyrosine protein) phosphatases II 1744-1994 1.1e-85 282.6 In-house 27-273 (278) alignment
Range on Protein: 1744-1994
Range on HMM: 27-273/278.0
SSNHPDNKHKNRYINIVAYDHSRVKlaqlaekdgkltDYINANYVDGYnrPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA
 .. ..|..|||| .|..|||||||            |||||.|.|||  ||..||.||||.||..|||||.||....||||.|.|||.|| ||.|||| 
palylgnldknRykdilpydhsrVk............dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpe

DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKgrpsGRVVTQYHYTQWPDMGVPEYS--LPVLTFVRKAAYAKRH-------------AVGP
.||..||.| || .|..|| .||.| ....|. ... . .     | ||..||. |||.|||...   ..| ...    | ..               ||
ggsltygdftvtllseevlddytlrtllvtnltveredle....srgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggp

VVVHCSAGVGRTGTYIVLDSMLQQIqhEGTVNIFGFLKHIRSQRNY-LVQTEEQYVFIHDTLVEAIL
|.||||||||||||..... ||...  ||.|...  .|..||||..  ||..|||.|... |.| .|
vlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

0042113 (Phosphotyrosine protein) phosphatases II 1744-1991 7.1e-83 273.0 In-house 3-241 (245) alignment
Range on Protein: 1744-1991
Range on HMM: 3-241/245.0
SSNHPDNKHKNRYINIVAYDHSRVKLAqlAEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA
....| ||.|||| .|..|||.||||    ..    .|||||.|||||.... .||.||||..| ||||||.||.....|||.|...|.|| ||.|||| 
vallpenkdknrysdilpydhtrvkls..pdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTkikkgsqkGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKR-HAVGPVVVHCSAGVGRTGT
..| .||.| || .|...|..||||.... |.        | .  | |..|||. |||.|||...  .| |.. .  | . .. |||.||||||||||||
gesltygdftvtllseehlddytvrtlevtnl........gddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGt

YIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVE
.|... ||.|...|..|...  .|..||||   |||..||.|... | |
fiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle

0037934 (Phosphotyrosine protein) phosphatases II 1744-1991 1.9e-78 258.6 In-house 4-240 (243) alignment
Range on Protein: 1744-1991
Range on HMM: 4-240/243.0
SSNHPDNKHKNRYINIVAYDHSRVKLaqlaekDGklTDYINANYVDGYNRpkaYIAAQGPLKSTAED----FWRMIWEHNVEVIVMITNLVEKGRRKCDQ
 ...| |..|||| .|..||||||||      .|  .||||||......|   .|| ||||..| ||    ||||.||....||||.|.|||.|| ||.|
iallpenlsknrysdilpydhsrvkl......eg..sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPadGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSqkgrpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAA----------YAKRHavGPV
|||  |...||.| || .|...|..||||...|.|..... .       | |..|||. |||.|||.   ..| |....           .....  |||
ywp..gevtygdftvtllseehlddytvrtlllenldlddlt.......rlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsg..gpv

VVHCSAGVGRTGTYIVLDSMLQQIqhegTVNIFGFLKHIRSQRNY-LVQTEEQYVFIHDTLVE
.||||||||||||.|... ||...    .|...  .|..|.||..  |||..||.|... | |
lVHCsaGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyealle

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1744-1991 9.3e-70 229.8 In-house 22-266 (274) alignment
Range on Protein: 1744-1991
Range on HMM: 22-266/274.0
SSNHPDNKHKNRYINIVAYDHSRVKLAQLAeKDGKLTDYINANYVDGYNR-PKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP
  . . ...|||| .|.  ..||| | .    . ....||||||. ||..  |||.|.|||| .| .||||||....|.||||.|.| |. ..|| .|.|
eldvfgsqtknryktilPnensrvlleses.sededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

ADG----SEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGsqkgrpsgrvVTQYHYTQWPDMGVPEYSLPVLTFVRKA---AYAKRHAVGPVVVHCSA
 .     ||.||.. .. ...     |.||...|.... ..           |. | ||.|||. .|.   ..| .|..    . .. . ..||||||||
daedyeiserygdveikvekiverndysvrklvlkylerers..........vkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsa

GVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVE
|.|||| .|  .  ..|...|..|....   ..| .|  .|||.||| .|| .|..
GiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1744-1998 9.2e-41 134.8 In-house 37-276 (288) alignment
Range on Protein: 1744-1998
Range on HMM: 37-276/288.0
SSNHPDNKHKNRYINIVAYDHSRVKLAqlaeKDGKLtdYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA
 ... .|  ..|| |.   | .||||      | ..  ||.|| |   . ..  | || ||..| | .|.|. | .|| |||...|.|||..| ..|.| 
idsfianptrdryenlprcditrvkls....ddpdf..yiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPs

DGSE--EYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQkgrpsgrVVTQYHYTQWPDMGVPEYSLPVLTFVRKAayakRHAVGPVVVHCSAGVGRTG
   |   .| .    |  ..    .|.  .||..|  . ..       .| . |. .|.| ||||  |. | ..       .    |.|||.||||||||
klGekarigrlctvvkkkradidklvkvsllriskegeekv.......ivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtg

TYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKET
| |.   .|.... .  . |  .|.. | .|   .||| ||...|  . | .| |  
tlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvleelllkky

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1744-1907 2.3e-34 113.6 In-house 27-182 (297) alignment
Range on Protein: 1744-1907
Range on HMM: 27-182/297.0
SSNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgklTDYINANYVDGYNRPK--AYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYW
|.. .   .|||| .|.|.| .|||| .   .    .|||||.||   . ..   || |||||..| .|||....|..| ||||...| | || ||  ||
sakrnsslrknryrdilatddtrvkllrvite....rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdkcapyw

PAD--GSEEYGNFLVTQKSVQVLAYYTVRNFTLrnTKIKKgsqkgrPSGRVVTQYHYTQWPDMGVPEY
|    .  . |...|   |     . .|    |  . | .         |||.   .  ||| |||  
psvvqerlkagdvvveflsstsdefdrviltel..qliyr......sesrvvrhvqflswpdhGvpsd

subfamily_egg_pd Subfamily egg 1744-1990 4.8e-29 96.0 In-house 34-267 (307) alignment
Range on Protein: 1744-1990
Range on HMM: 34-267/307.0
SSNHPDNKHKNRYINIVAYDHSRVKLaQLAeKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKgrRKCDQYWPA
 .   .|..| |   .   | ||||| .|  .   | |.| ||.|.|      .| || ||| | .|||||... .|. |||.|  .|    .|. ||| 
taasdnnlekarskrvhckdssrvkl.elr.rGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpk

DGSEEYgNFLVTQKSVQVLAYYTVRNFTLRNTKIKKgsQ--KgrPSGRVVTQYhYTQWPDMGVPEYSlpvLTFVRKAayakRHAVGPVVVHCSAGVGRTG
  |.    ..     .. |  .   .  .| ||.|      .     | .  .   ..  ..   .    |  .||.    |..  ||||..  || ...
aesdsl.vtvpGslrienlkvdskadplfrvtklkl..vGgd..deerflehw.qgdvnnssdvysp...lrvlrkl....rnlskpvvvqdilGvskaa

TYIVLDSMLQQIQHEGTV--NIFGFLKHIRSQRNYLVQTEEQYVFIHDTLV
| . ..  | ..    ..   .    . .| .|.. |..  .|.|..  ..
tlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl

0040439 (Phosphotyrosine protein) phosphatases II 1745-1993 1.8e-85 281.8 In-house 6-246 (249) alignment
Range on Protein: 1745-1993
Range on HMM: 6-246/249.0
SNHPDNKHKNRYINIVAYDHSRVKLAQLAEkdGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAD
...| ||.|||| .|..||||||||  | .  . |.|||||.|.|||......||.||||..| ||||||.||....||||.|.|||.|| ||.|||| .
allpenkdknrypdilpydhsrvklsilpg..lflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplg

GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTkikkgsqkGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRH--AVGPVVVHCSAGVGRTGT
|| |||.| || .||.|...||||...| |.        . .. | |....|| |||.|||..  ..| |....  | ..    |||.||||||||||||
gsleygdftvtllsvevkddytvrtleltnl........ydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGt

YIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
.|... ||.|...|..|...  .|..||||.. ||..|||.|... | | .
fiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1745-1995 3.1e-83 273.8 In-house 4-244 (250) alignment
Range on Protein: 1745-1995
Range on HMM: 4-244/250.0
SNHPDNKHKNRYINIVAYDHSRVKLAQlaEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRkCDQYWPAD
...|.||.|||| .|.|.|.||| | .  ||  | .||||| ...||.  ||.||.||||..| ||||||..|.....|||.|||.|...  . ||||..
akkpqnkeknryadiialdssrvvLek..ekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

GSEEYGNFLVTQKSVQVLAYYTVRNFTLrnTKIKKGSQkgrpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRH-AVGPVVVHCSAGVGRTGTY
..|.||. .|. .| .. | ||.|.. |  .| || ..      |.| |.|...||| ||||.   || ...|    ...   .||.|.|||||||.|..
kaekyGdvtvsllskeefadytkrklkl..skakkade......rivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGaf

IVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS
|..|..|.....| .|..| ..| .| .|   |...|||||..  . .|. |
iaidavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds

subfamily_CG7180_pd Subfamily CG7180 1745-1997 1.9e-62 205.6 In-house 37-294 (296) alignment
Range on Protein: 1745-1997
Range on HMM: 37-294/296.0
SNHPDNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRrKCDQYWPAD
  . .|. |||....| ||. || | .|  .  . .||||| |||.. ..|.||  ..| |.| ..|||........ .|..|.  .  . .. .||| .
glrkenreknrdvkvvPyDynRvvLekldGe..eksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.mypsywpnk

GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNT--KIKKGSQKGRPSGRVVTQYHYTQWPD-MGVPEYSLPVLTFVRKAAYAKRH-----AVGPVVVHCSAG
. |.||...|   ... .|  . |.| |  .   . .  ..     |.|.....|.|.    ||  .  .. ..|..   ...       |||||..| |
skeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvvvvssdG

VGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKE
..|.| |. .|  |.....|. |..|...| .| .|. ||.. |.| .| |.| ||.| . 
asRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk

subfamily_CG42327_pd Subfamily CG42327 1745-1915 2.4e-33 110.2 In-house 23-187 (319) alignment
Range on Protein: 1745-1915
Range on HMM: 23-187/319.0
SNHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGYNR-PKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA
   .  | |.|.||.|   ..|| | . ...|   . |..|.|| ||.  |  ||||| .|.... ||||..|| .  ||| .|.| |.| ..| .|.|.
evPvtskdksrvinvvPlPetrvvlqrigdddk..deyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPt

----DGSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKikkGSqkgrpSGRVVTQYHYtQWPDMGVPEYSLPVLTFV
    |. . ||..||| |  .|   | .  . |.. .   ..       | .| | | .|.. .||    .... .
ketldntslyGdilvtlkgrevkdryaistlllkrvd...ke.....esrelthywy.kwleaevPaeeaaliaml

subfamily_ptpA1_pd Subfamily ptpA1 1746-1955 6.5e-42 138.7 In-house 43-258 (418) alignment
Range on Protein: 1746-1955
Range on HMM: 43-258/418.0
NHPDNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINANYVDGyNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAD-
..  |  |||| ||.  .|.||.| .. .|.|  .|||||||.||   || .|..||||  |  |||||.||  . .|||..   |. | |||.||| . 
dkkhntsknrytnilpvnhtrvqlkkiqdkeg..sdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcriivmlsresencrikcdrywpeqi

GSEEY-----GNFLVTQKSVQVLAYY--TVRNFTLRNTKIkkgsqKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKR------HAVGPVVV
| |..     || ..   ||...       |.   || ..           | .|||.|  |||  .|... |.  ...  .  .           |..|
ggeqfsiygngnevfgtysvelveviqdpereiitrnirl.....tfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqnqiipssdrnvpiiv

HCSAGVGRTGTYIVLDSMLQQIQH
|||||||||||.     |.....|
hcsagvgrtgtfctavimmkkldh

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1747-2003 3.2e-40 132.6 In-house 49-299 (310) alignment
Range on Protein: 1747-2003
Range on HMM: 49-299/310.0
HPDNKHKNRYINIVAYDHSRVKLAQlaeKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADG-
. .. ||||| ..|  | |||||        .  ||| ||||      ...| .||||. |  ||||||..   | |... . .|.|| ||  |||. | 
ykkymhknrysdvvcldtsrvklki...dksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgv

SEEYGNFLVTQKSVQVLAyYTVRN--FTLRNTKIKKGSQKGRPSGRVVTQYHYTQWPDMGVPEYSLpvLTFVRKAAYAKRHavGPVVVHCSAGVGRTGTY
.| ||   ||. |      . . |   |.   ..    |     .  |.  .. .|||.|||.      |  ..     ||  ||.|||||||..|... 
tetygcirvtnlsessee.feicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekc..htvpqrllaqvrh..gpcvvhcsagkdrlyvv

IVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVeAILSKETEVLDS
. |.  ......   |..     ... .|   .||| ||..|.   . ..   |||| ..
valklkidkldrglkvdaeevktellksraiciqtelqyliidrvri.ifargetevaek

subfamily_eak_pd Subfamily eak 1747-2011 1.2e-17 58.3 In-house 49-325 (332) alignment
Range on Protein: 1747-2011
Range on HMM: 49-325/332.0
HPDNKHKNrYINIVAYDHSRVKLAQLAEkdgKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGS
  .. ..|  ..|| ||.  |.|.           ||||  ..  .  . || .  . ..    ||.|. | .   ||.. . ||..  | |.|.| .. 
rleavnrn.vvkivpydrylvrltssql...nrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr

E--EYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSGRVVTQ--------YHYTQWPDMGVPEYSLPVLTFVRKAaYAKRHAVGP---VVVHC
|  ..| . |..|.    . . .|.. |.     .  .. .  |   |.          .    ..||.    .  . ..   . | .   |    .. .
eelkfGildverkefvkrniletrllelskGnethrvlhykvfGwtettlpkyedflalrkvmkevGvlllivmksallsst.lkkyihtppsfapiiqs

SAGVGRTGTYIVLDSMLQQIQHEG--TVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEV--LDSHIHAYVNA
. |  |.|...|.| ... |.     .  .  ..  ..|.|.. | .. |. ||.. ... .| .. ..  |. .. || ..
arGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyllrrnnrlrdlkkyleayaes

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1748-2006 3.4e-50 165.5 In-house 46-298 (305) alignment
Range on Protein: 1748-2006
Range on HMM: 46-298/305.0
PDNKHKNRYINIVAYDHSRVKLaqlaeKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSE
 ....|||| ..   |. ||||     .     .|| ||||     || .| .| ||. |  ||| | ....|| | |. ||.||| .|| .|....  .
aqeagknrykdvgcldnnrvkl.....egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkd

EYgNFLVTQKSVQVL--AYYTVRNFTLRNTKIKKGSQKG---RPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAayakRHAVGPVVVHCSAGVGRTGT
.  .|   .. ..|   .  |..  .  ..|...          . | ||.||. .||| |||   | .| .. ||    | . ||.|||||||.||||.
vl.efeekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtgs

YIVLDSMLQQIQHEGTVN-IFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKetEVLDSHIH
 ..|. .|.|.     ..     |..|| |||  .||..||.|.|. ... .. |  ..|| ...
vvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk..klldeevk

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1748-1996 9.6e-22 72.0 In-house 45-282 (303) alignment
Range on Protein: 1748-1996
Range on HMM: 45-282/303.0
PDNKHKNRYINIVAYDHSRVKLAQlaekdgklTDYINANYVDgYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADgsE
 .| .|||.....  |||.|||..        . || |.|..  .  |  | .| ||  || |||.|| | .| .....    |  .   |  .| .  .
vknmdknrfvdvicldhskvklsd........ssyihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn..q

EYGNFlvTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPsgRVVTQYHYTQWPDMGVPEYSLPV--LTFVRKAAYAKRHA-VGPVVVHCSAGVGRTGTYI
.. .|   ..|..|  .  |      . |.   |.        .  .|| .||   .|  . |       .  .. ....   | |    .|.||.||. 
dflkf..eersirvgefkrvelgdgwvlkvlsvsngdyk..sflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfa

VLDSMLQQIQH-EGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
....    ..  . ....   |. .|  | . ||   |. ...  | | .| .
lfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvldn

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1749-1990 2.7e-72 237.8 In-house 7-238 (239) alignment
Range on Protein: 1749-1990
Range on HMM: 7-238/239.0
DNKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYN-RPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPaDGSE
 || |||| |||.|||||| | .|..     .|||||.|.  |.  ||||||.|| .. .. |||||.|.    ||||.| |.|  ..|| |||| | . 
vnkaknryanivtydhsrvvleklsnd..phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dsts

EYGNFLVTQKSVQVLAYYTVRNFTLrntkikkgSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLD
.| |. || .  .|.| | .| | .        || |.   | | |||.| ||| |||.|.  || . || .        | |.||||||||||...|.|
kycnlrvtlrktevfadyiirtfvm........sqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvid

SMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLV
.||.| ... ||.|| ..| || .| ..||| ||||||| ...
amlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1749-1991 2e-71 235.0 In-house 2-237 (237) alignment
Range on Protein: 1749-1991
Range on HMM: 2-237/237.0
DNKHKNRYINIVAYDHSRVKLAQLAEKdgklTDYINANYVDGYN-RPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA-DGS
.|| |||| |||||||||| |     .    .|||||.|..|..  || ||||||||.|. .|||.|.|. .  ||||.| |.|. . || .|||  |  
enkiknrygnivaydhsrvvlkgagsg....sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqp

EEYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKgsqkgrpSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRH--AVGPVVVHCSAGVGRTGTYI
. || . |. |  . .. |||| ..| .   .|         |.. ||..| ||| |||...  .| | ..     .|    || ..|||||||||| ..
aaygvltvslkkkeefsdytvrslllskrltlk.......evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgifl

VLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVE
|.|.||.| . .  |.|. ... |  .| |..||..||||||.|..|
vidamlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1749-1992 1.4e-63 209.5 In-house 19-263 (270) alignment
Range on Protein: 1749-1992
Range on HMM: 19-263/270.0
DNKHKNRYINIVAYDHSRVKLAQLAEkdGKLTDYINANYVDGY-NRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAdgsE
 .|. ||| .|.   ..||.|..| |   . | ||||||| |. ...|.||||.|||..| ..|||||||..|. |||.|.|.||||.||..||||   |
rgkklnRyadiLPsPatRvrleelee..dsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpa...e

EYGNFLVTQKSVQVLAYYTVRNFTLRNTKIKKGsQKGRpSGRVVtQYHYTQWPDMGVPEYSL------PVLTFVRKA---AYAKRHAVgPVVVHCSAGVG
   .  ...  ..|||  ....   . |...   .||  . |.|  ..|..||| |||. .        .|. .|.       ...|  |..||||||||
pkekvkledgkikvlalseekeegyiltrlrle.ekge.errlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHcsaGvg

RTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEA
|||| |.|| ... ..... |..   ....| .|  |||. ||| |.. ..|| 
RtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1749-1999 8.5e-43 141.1 In-house 54-295 (305) alignment
Range on Protein: 1749-1999
Range on HMM: 54-295/305.0
DNKHKNRYINIVAYDHSRVKLAQLAekdgkLTDYINANYVDGYNRP-KAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSE
 .. |||| .. . |.| |||.. .      .||| ||||     | | .|.|||||  | ..|| |. ...|| |||. . || |. || |||||   |
iaitknryqdvpcqdqsavkldkps.....psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

EygnflVTQKSVQVLAYYTVRNFTLRNTKIKKGSQKGRPSG---RVVTQYHYTQWPDMGVPEYSLPVLTFVRkaayAKRHAVGPVVVHCSAGVGRTGTYI
      .. ||  |.   .  .   |...|.    .   ||     | . ..|.||| |||   |  | ..     | | .  |.|||||||.||||| .
k.....lelksgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslells....airgskvpivvhcsagigrtgtiv

VLDSMLQQIQHEGTV-NIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETE
 .. .|..|  .  .  .  ..| .| || . .|.. ||.|||  ... .| |  |
aieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflekyke

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1749-1995 8.2e-27 88.9 In-house 34-272 (285) alignment
Range on Protein: 1749-1995
Range on HMM: 34-272/285.0
DNKHKNRYINIVAYDHSRVKLAQlaeKDgklTDYINANYVDGYNRP-KAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSE
 |   ||| .. . . .|| | .   .|    ||| |...    .   .||..||||  |  |||.||.. ..  ..|.  |.| |  ||  |.|    |
anpdlnryadvrcieetrvvlkn...hd...rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklge

--EYGNFLVTQKSVQVLAY--YTVRNFTLRNTKikKGSQkgRPsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKrHAVGPVVVHCSAGVGRTGTY
  ..|.. .|   ..  |     . ..|. ||.    |    |    . . .   |||   || . |.. . .     .     |..|||||||||| |.
vvkfgkyeitlteckeeaiagtilnaltvinte..dass..ep..lymnhvqvpwwpdqlapedarpmielykwvkkvn.pkekpicvhcsagvgrtatf

IVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS
. .|    .|  .  ....  .. .|. |   ||.  |..|..  |.| .. 
vgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyfig

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 1749-1840 3e-15 50.5 In-house 33-121 (332) alignment
Range on Protein: 1749-1840
Range on HMM: 33-121/332.0
DNKHKNRYINIVAYDHSRVKLAqlaEKDGKlTDYINANYVDGYNRPKAYIAAQGPLKSTAE-DFWRMIWEHNVEVIVMITNLVEKGRRKCDQY
.|   ||   . ..|||||.||    .|||  |. ||..||||..  ||| || |..  .|  ||||. |..  .|... .. || .||.   
nnmdmnriphlycfdhsrvela...pqdgk.ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapyd

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 1749-1844 2.2e-08 27.2 In-house 26-87 (169) alignment
Range on Protein: 1749-1844
Range on HMM: 26-87/169.0
DNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINAnyvdgynrpkayiaaqgplkstaedfwRMIWEHNVEVIVMITNLVEKgrrkcDQYWPAD
 |. |||    .|  | |||| .. |. |  .|||||                           ||||| |  |||.. .  .|     ...||  
cnetknrpagplapshtrvklqrvmedlg..sdyina...........................rmiwetnasvivvlgdtddk.....nnfwpek

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 1749-1843 2.8e-08 26.8 In-house 25-85 (169) alignment
Range on Protein: 1749-1843
Range on HMM: 25-85/169.0
DNKHKNRYINIVAYDHSRVKLAQLAEKDGklTDYINAnyvdgynrpkayiaaqgplkstaedfwRMIWEHNVEVIVMITNLVEKgrrkcDQYWPA
 |. |||    .|  | |||| .. |. |  .|||||                           ||||| |  |||.. .  .|     ...|| 
cnetknrpagplapshtrvklqrvmedlg..sdyina...........................rmiwetnasvivvlGdtddk.....nnfwpe

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1749-1827 4e-08 27.2 In-house 36-117 (347) alignment
Range on Protein: 1749-1827
Range on HMM: 36-117/347.0
DNKHKNRYINIVAYDHSRVKLAQLAEKDGKL---TDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMIT
 .  |||  .    | .|| |.    | ..      |||| ..   |  | || .| || .|  |||.|.   .|  .| | 
kslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtif

Y_phosphatase Protein-tyrosine phosphatase 1750-1990 3.1e-89 293.8 Pfam-A 1-234 (235) alignment
Range on Protein: 1750-1990
Range on HMM: 1-234/235.0
NKHKNRYINIVAYDHSRVKLaqlaEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--ADGSE
||.|||| .|..||..||||    ..... .||||||||.||...|..||.||||||| ||||||.|...|.||||.|.|.||||.||.||||   ..|.
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EYGNFLVTQK-SVQ-VLAYYTVRNFTLRNTKIKKgsqkgrpSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIV
.||.. |. | ...   . ||.|...|...| ..         | |.|.|||.||| |||| . ..| ..||    |..  ||||||||||||||||...
tygdikvelkekekedekeytlrklelkkkkees.......ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfva

LDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLV
|| .|.|...|..|... ..|..|.||. .||..|||.|......
ldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 1750-1990 3.1e-89 293.8 In-house 1-234 (235) alignment
Range on Protein: 1750-1990
Range on HMM: 1-234/235.0
NKHKNRYINIVAYDHSRVKLaqlaEKDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWP--ADGSE
||.|||| .|..||..||||    ..... .||||||||.||...|..||.||||||| ||||||.|...|.||||.|.|.||||.||.||||   ..|.
nkkknRykdilpydktrvkl....kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesl

EYGNFLVTQK-SVQ-VLAYYTVRNFTLRNTKIKKgsqkgrpSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIV
.||.. |. | ...   . ||.|...|...| ..         | |.|.|||.||| |||| . ..| ..||    |..  ||||||||||||||||...
tygdikvelkekekedekeytlrklelkkkkees.......ekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfva

LDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLV
|| .|.|...|..|... ..|..|.||. .||..|||.|......
ldilleqleaeeevdvlqivkelRkqRpgmvqsleqYiflykail

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1750-1992 1e-72 239.1 In-house 7-239 (239) alignment
Range on Protein: 1750-1992
Range on HMM: 7-239/239.0
NKHKNRYINIVAYDHSRVKLAQLAEKdgKLTDYINANYVDGYN-RPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPaDGSEE
|| |||| |||.|||||| | .|..     .|||||.|.  |.  ||||||.|| .. .. |||||.|.    ||||.| |.|  ..|| |||| | . .
nkaknryanivtydhsrvvleklsnd..phsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywp.dstsk

YGNFLVTQKSVQVLAYYTVRNFTLrntkikkgSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDS
| |. || .  .|.| | .| | .        || |.   | | |||.| ||| |||.|.  || . || .        | |.||||||||||...|.|.
ycnlrvtlrktevfadyiirtfvm........sqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida

MLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEA
||.| ... ||.|| ..| || .| ..||| ||||||| ...||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1750-2031 1e-69 230.0 In-house 43-315 (515) alignment
Range on Protein: 1750-2031
Range on HMM: 43-315/515.0
NKHKNRYINIVAYDHSRVKLAQLAekDGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA--DGSE
| .|||| ||. || .||||  .   |    ||.|| |. ...  |||||.|||.|.. .||||.....||  |.|.|.| |  . || .|||     | 
nfkknryknilPydsvrvklevin..dnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsv

EYGNFLVTQKSVQvlayyTVRNFTLRNTKIKKGSQkgrpsGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLD
..|.. |   |..     .  . . |. .. ||..      | |||.|.|.||| |||. .  .| ....    . .   |...|||||||||| .| .|
kfGsikvelvsle.....actggikrkltvlkgdd.....srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisid

SMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKETEVLDSHIHAYVNALLIPGP-AGKTKLEKQFQLLS
|.. ...   .|..| |.. || .| |||||.||| ||.... | .| ..| .   |.  ... |   |   |..|. |.|| | 
svvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkefqtlk

0041856 (Phosphotyrosine protein) phosphatases II 1750-1998 1.5e-52 173.2 In-house 1-176 (182) alignment
Range on Protein: 1750-1998
Range on HMM: 1-176/182.0
NKHKNRYINIVAYDHSRvklaqlaekdgkLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITnlvekgrrkCDQYWPadgseey
|..|||| .|. |||||              ||||||...|. ... .||.||||.|| .||.||..|... .||..|         ...|||       
nldknrysdilpydhsr............dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywp.......

gnflvtqksvqvlayytvR-NftlrntkikkgsqkgrpsGRVVTQYHYTQWPDMGVPEySLPVLTFVRKAAYakrhAVGPVVVHCSAGVGRTGTYIVLDS
                                        | ..||.|..|||.|||.    .| |....        |||.||||||||||||..... 
..................ell..................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaayl

MLQQiqhegTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKET
|...      |...  .|..||.|.  |.|..||.|... | | .| |.|
mkkl.....gvsleeavklvrsrRpgmvitpnqyfflqlallellllkkt

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1750-1997 6.1e-29 95.7 In-house 43-280 (312) alignment
Range on Protein: 1750-1997
Range on HMM: 43-280/312.0
NKHKNRYINIVAYDHSRVKLAqlaekdGKLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA-DGSEE
 |  ||| ||  .|  |  ||      |    || ||.|    .|. ....||||..|.  ||..        |.... .|| |  || .|     |  .
fkdlnrypniqcwdrgrftla......gdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvd

YGNFLVTQKSVQVLAY--YTVRNFTLRNTKIkkgSQKGRPSGRVVTQYHYTQWPDMGVPEYSLpvlTFVRKAAYAKrHAVGPVVVHCSAGVGRTGTYIVL
  .  |  ...  .     .  . | |  |.     |       . .| .. ||| |.|.      |  |  .  | .   ||. ||||||||||| ...
ledhrvyteycteieiggkskdkithrvlkv...vvkatgqesklnhyqwaswpdhgmpdscd...talrllsavk.kdkkpviahcsagvgrtgtlali

DSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSKE
.||.  ..|    |.   .  .| .|   |..  |||.   ...| . || 
esmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflyskg

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1751-1991 3.8e-45 148.8 In-house 57-281 (290) alignment
Range on Protein: 1751-1991
Range on HMM: 57-281/290.0
KHKNRYINIVAYDHSRVKLaqlaeKDGKLTDYINANYVDGYNRPkaYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSE--E
 .|||| ..|  | .|| |     |||   ||. ||||.| . .  .| .||.||.|. |.|||. ...| .|||. .|.|.|. ||.||.|    |   
fkknrykdvvcndktrvil.....kdGydGdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevlt

YGNFLVTQK-SVQVLAYYTVRNFTLRNTKikkgsqKGRpsGRVVTQYHYTQWPDMGVPEYSLPVLTFVrkaaYAKRHAVGPVVVHCSAGVGRTGTYIVLD
.|.. |.   . .  |    . ...|. .      .|.    ..  ..   |||  |.  .| .|  .    .. |.| ||||||||||.|||||.. ..
fGeitvlcseeddkdaniikktlsvrdkd......sGk..ehklkhlkikswpdksvalstlallrtl....rilrkasGpvvvhcsaGiGrtGtfvaie

SMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVE
  || . .   ... .  . .|  |   || . ||. . . |..
vglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1751-1990 7.2e-39 128.5 In-house 48-341 (350) alignment
Range on Protein: 1751-1990
Range on HMM: 48-341/350.0
KHKNRYINIVAYDHSRVKLA-QLA-----EKDGKLTDYINANYVDGY-----NRPKA-YIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCD
  |||| ||. |.||||||   |      ..  .  |||||||.          |.  |||.|.||.|| .||...| . .|.||...|..|| ...||.
faknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcy

QYWPADGSEE--------YGNFLVTQKSVQVLAYYTVRNF----TLRNTKIKKGS-----QKGRPSGRVVTQYHYTQWPDMGV---PEYSLPVLT-----
.||.  . ..        . |   ...|..  |              ....|.       .       || | .. .|.|...   ||  |..|      
rYWqegsydditvklaskwenimgindsslysadvkkeasdndnisddndlkdnnsltaitlaasdPyvvyqlqvknWkDlslllnPesilqalevkndl

--FVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQ------QIQHEG---------TVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLV
        . .     |..||||||||||||.. |||.|.      ....|             |.  ....|.||  .||. .|..||...| 
iddlfaeshldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1752-1843 2.8e-19 63.6 In-house 50-155 (349) alignment
Range on Protein: 1752-1843
Range on HMM: 50-155/349.0
HKNRYINIVAYDHSRVKLAQL------------AEKDGKLTDYINANYVD--GYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKC
 |||| .|. |.|||||| .               . ||| |||||||.    ..  | ||| | || || .||...|   .|.... ...  |.. .||
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

DQYWPA
|.||  
diywqe

0044763 (Phosphotyrosine protein) phosphatases II 1762-1987 3e-37 123.3 In-house 2-165 (178) alignment
Range on Protein: 1762-1987
Range on HMM: 2-165/178.0
YDHSRVKLAQLaeKDGKLTDYINANYVDGYnrpkAYIAAQGPlkstaEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSeeygnflvtqksvqv
.|..||.|  |   .   .|||||......     |.....|     .|......|... .||..|. .| |. |||.||| . .               
ldrtrvllsnl..eglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

layytvrnftlrntkikkgsqkgrpsgrvvTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQiqhegTVNI
                               ||... .||.|||. .  .| ||.    |     |||.|||||||||.|| .... |...      ...
..............................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsl

FGFLKHIRSQRNyLVQTEEQYVFIHD
.  ....|..|.  |....|. ....
eeaielvrerRp.ivpnpgqlrqLye

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1762-1848 6.6e-10 33.4 In-house 5-76 (130) alignment
Range on Protein: 1762-1848
Range on HMM: 5-76/130.0
YDHSRVKlaqlaekdgkLTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKgrrkcDQYWPADGSEE
.. ||..            .||||..|   .| . |. .| ||  |. |||.|. |  |.|.|..  . |.     |.|||     |
fevsrlq..........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpdsePle

0046846 (Phosphotyrosine protein) phosphatases II 1778-1989 1.6e-44 147.1 In-house 10-169 (176) alignment
Range on Protein: 1778-1989
Range on HMM: 10-169/176.0
KLTDYINANYVDGYnrpkAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYgnflvtqksvqvlayytvrnftlrntki
   ||||||...|.    ..|| |||| .| .||..|..|......|..|..||.|| ||..|||   ....                            
ldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

kkgsqkgrpsgrvvtQYHYTQWPDMGVPEYsLPVLTFVRKAAYAKRHAvGPVVVHCSAGVGRTGTYIVLDsmlqQIQHEGTVNIFGFLKHIRSQRN-YLV
               ||... |||.|||..   .|....    | ..  |||.||||||.|||||.....     ...|  ....  |...|.||  . |
...............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgav

QTEEQYVFIHDTL
||.||| |... .
qtpeQyrflyefe

0051429 (Phosphotyrosine protein) phosphatases II 1779-1994 7.7e-57 188.2 In-house 3-226 (272) alignment
Range on Protein: 1779-1994
Range on HMM: 3-226/272.0
LTDYINANYVDGYNR---PKAYIAAQGPLKSTAEDFWRMiWEHNVEVIVMITNLVEKGRRKCDQYWP------------ADGSEEYGNFLVTQKSVQVLA
|..||||..|.||.|   |.......|||. ||.||||. .|... .||......|.|| |||.|||            .. . .||.. ||  |...| 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

YYTVRNFTLRNTKIKKGSqkgrpsgRVVTQYHYTQWPDMGVP-EYSLPVLTFVRKaayakrhaVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVN--
.|..|...|...   . .       | |...|||.|||.||| |. | .| ....         |||.||||||..||||...|. .|... .|  |.  
dyilrellltlllsagea.......revmhlhytdwpdhgvpqeallellellld........ggpvlvHCsaGkdRTGtvvallllllgvsletivddY

------IFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAIL
      ........|.|| . |||||||.|... |.|.. 
lltnlyleeaveelraqrpgavqteeqylflyeallellr

0043147 (Phosphotyrosine protein) phosphatases II 1779-1986 1.5e-43 143.8 In-house 4-154 (172) alignment
Range on Protein: 1779-1986
Range on HMM: 4-154/172.0
LTDYINANYVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLvekgrrkcdqywpadgseeygnflvtqksvqvlayytvrnftlrntkik
 .|||||.|.|.|  |. .|| |||| .| .|||||..|... .||..|.|                                                 
gsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel.................................................

kgSQKGRPSGRVVTQYHYTQWPDMGVPeYSLPVLTFVRKAAY-AKRHAVGPVVVHCSAGVGRTGTYIVLDSMLqqiqheGTVNIFGFLKHIRSQRNYLVQ
     . .  | . ||.|. |||.|||  .  .| |..     . .   |||.|||||||||||| .... ||        ....  ....|..|.. ||
..lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavq

TEEQYVFIH
...|| |..
npsqyrfly

0051082 (Phosphotyrosine protein) phosphatases II 1779-1989 2.1e-36 120.1 In-house 2-149 (151) alignment
Range on Protein: 1779-1989
Range on HMM: 2-149/151.0
LTDYINANYVDGYnrpkaYIAAQGPlkstAEDFWRMIWEHNVEVIVMITNLVEKGrrKCDQYWPADGseeygnflvtqksvqvlayytvrnftlrntkik
|.||||..||.|.     ... .||     .||.....|... .||......| |  .| .|.|. |                                 
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg..ycpeylpelg.................................

kgsqkgrpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYakrHAVGPVVVHCSAGVGRTGTYIVLDSMLQQiqhegtVNIFGFLKHIRSQRNYLVQT
          . |...... ||| |.|..   || |.....    .  |||.||||||.||||| ..|. ||..      |...  |...|..| ..||.
..........ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqp

EEQYVFIHDTL
..|..|..  |
nqqflfqlfal

0036282 (Phosphotyrosine protein) phosphatases II 1780-1987 7.6e-48 157.8 In-house 2-164 (174) alignment
Range on Protein: 1780-1987
Range on HMM: 2-164/174.0
TDYINANYVDGYNRPKAYIAAQGPLKstaedFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAdgseeygnflvtqksvqvlayytvrnftlrntkikk
.|||||...|.. ... .|| ||||.     ||.|..|......|| ....|.|. || .|||                                     
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe....................................

gsqKGRPSGRVVTQYHYTQWPDMGVPEYSLpVLTFVRKAAYAKRH-AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQhEGTVNIFGFLKHIRSQRNYLVQT
   .     | . ||.|. |||.|||. |  .|.||. .  |  .   |||.|||||||||||| .... ||...  |..|... ... .|.|| . |||
...lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqt

EEQYVFIHD
..|| |...
psQyrflyy

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1780-1990 3.5e-17 57.5 In-house 46-256 (290) alignment
Range on Protein: 1780-1990
Range on HMM: 46-256/290.0
TDYINANYVDgYNRPKAYIAAQGPLK-------STAEDFWRMIWEHNVEVIVMITNLVEKGRR----KCDQYWPADGSEEygnFLVTQKSVQVLAYYTVR
 ||| ||.|  .    . |. | |..       || |.|| |. . .|. .||. .  || .      | .| |    ||     .   .|.     .. 
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgee...lkfkgltvkCkskeked

NFTLRNTKIKKGSQKGrpsgRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAyakrHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQ-HEGTVNIFGFLKH
..  |.  .| . ..       || . . .| .. |.| .. .|. ..|          ||.|||  |. |  .   ..   | |   .| |..   || 
dvetRelvvkfddeee....ftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlka

IRSQRNYLVQTEEQYVFIHDTLV
.|.||. ........ |.   .|
lrkqralaitsalelafvdagiv

0049260 (Phosphotyrosine protein) phosphatases II 1787-1987 5.8e-45 148.0 In-house 1-144 (152) alignment
Range on Protein: 1787-1987
Range on HMM: 1-144/152.0
YVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWpadgseeygnflvtqksvqvlayytvrnftlrntkikkgsqkgrp
..|||..|...||.|||.  |..|||||..|... .|||.|.|.|.|. ||.||.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

sgrvvtQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLqqiqheGTVNIFGFLKHIRSQRNYLVQTEEQYVFIH
      ||....|||.|||. |  .| ...    ....  |||.||||||||||||..... ||        |... .....|..|.. |....|. |..
......qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrfly

D
.
e

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1789-1873 3.3e-12 40.5 In-house 230-312 (440) alignment
Range on Protein: 1789-1873
Range on HMM: 230-312/440.0
DGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKgrrKCDQYWPADG-SEEYGNFLVTQKSVQVLAYYTVRNFTLR
.|| . .|.||.| || ||  ||||.. ....  |.|. .| .|    |  ||| .  |  .| | | .|  . .    || . |.
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlndk...tcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelk

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1795-1986 1.2e-23 78.3 In-house 5-197 (199) alignment
Range on Protein: 1795-1986
Range on HMM: 5-197/199.0
KAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAD--GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKikkgsqKGRPSGRVVT
. |||.| ||. |  |||.|.||     |||. .   .       |||.   |. .||.. || |.. . . ||.  . | |           || | ..
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnt......tappstreis

QYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRH---AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHE--GTVNIFGFLKHIRSQRNYLVQTEEQYVFIH
.| .| | .   |. .| |   |     .|..      ||.|||| | | || .. ||  ..  .      |..|   | .|  |  .. . ..| ||.
hyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1795-1986 1.2e-23 78.3 In-house 4-196 (198) alignment
Range on Protein: 1795-1986
Range on HMM: 4-196/198.0
KAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAD--GSEEYGNFLVTQKSVQVLAYYTVRNFTLRNTKikkgsqKGRPSGRVVT
. |||.| ||. |  |||.|.||     |||. .   .       |||.   |. .||.. || |.. . . ||.  . | |           || | ..
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnt......tappstreis

QYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRH---AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHE--GTVNIFGFLKHIRSQRNYLVQTEEQYVFIH
.| .| | .   |. .| |   |     .|..      ||.|||| | | || .. ||  ..  .      |..|   | .|  |  .. . ..| ||.
hyqftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy

subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1799-1991 3.4e-20 67.2 In-house 39-219 (255) alignment
Range on Protein: 1799-1991
Range on HMM: 39-219/255.0
AaqgplksTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEYgnfLVtqKSVQVLAYYTVRNFTLRNTKIKKGSQKgRPSGRVVTQYHYTQ
        | . |...|   . ||.||.... |.|. ||..|.| .  |      .  . |.| .  .. .  ||  .|     . .   . |. |.|. 
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdekl...kl..advnvtttkssadvvlrtleitstlge.kkkthtvkhysykG

WPDMGVPEYSLPVLTFVRKAAYAKrhavgPVVVHCSAGVGRTGTYIVLDSMLQ----QIQHEGTVNI--FGFLKHIRSQRNYLVQTEEQYVFIHDTLVE
|..   || .  .|  .. .  .|     .||||||.|.||. .... ... |    ...   ||..    .|...||.|.  ..|  |  |   ....
WieknaPelareilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld

subfamily_hpo-7_pd Subfamily hpo-7 1799-1989 1.7e-17 58.2 In-house 42-223 (263) alignment
Range on Protein: 1799-1989
Range on HMM: 42-223/263.0
AaqgpLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPA--DGSEEYGNFLVTQKSVQVlayytvrNFTLRNTKIKKGSQKgRPSGRVVTQYHY
     |  | . |...|   . ||.||...  |.|. ||..|.|   |.   . |  |.   ||        .  |.  .. .  .. .   . |..| |
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.......dvllktlellstlge.Kkkthtvkhysy

TQWPDMGVPEYSLPVLTFVRKAAYAKrhavgPVVVHCSAGVGRTGTYIVLDSMLQ----QIQHEGTVNI--FGFLKHIRSQRNYLVQTEEQYVFIHDTL
. |..   || .  .|  .. |   |     ..|||||.|.||.  . | ... |    ...   ||..    .|...||.|.  ..|  |  |   ..
kgWiekndpelareilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmv

subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1800-1998 5.1e-27 89.1 In-house 96-293 (302) alignment
Range on Protein: 1800-1998
Range on HMM: 96-293/302.0
AQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPAD--GSEEYGNFLVTQKSVQV-LAYYTV-RNFTLRNTKIKKGSQKGrPSGRVVTQYH
   | ||| | .| .| ..|| ..| ....||.. .|| .|.  .  |  ..|.. |. .||.  |. .|  ..|.| . .||   .|     . |   .
pivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkk.kvkktvdila

YTQWPDMGVPEYSLPVLTFVRKAAYAKRHavgpVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILS
.. ||| | |. . . |  ..     |.     |.|||||||||||| . .   .|  ... . ..   .. .|. |   ||.|.| ...   .  ... 
fsawpdhGapkeaytaldilkfcesykkn....vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcvtkglme

KET
|..
kag

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1803-1996 2.4e-07 23.7 In-house 123-312 (346) alignment
Range on Protein: 1803-1996
Range on HMM: 123-312/346.0
P---LKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPADGSEEY-GNFLVTQKSVQVLAyyTVRNFTLRNtkIKkgsqKGRpSGRVVTQ-YHYT
|    .|  |||| ||.. ..... ..             .   .|  .| |.... ..  .|      ...|.    .     .|  |  |. | .|..
pqmenesfvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsg..dpkeytiev..lp....egn.sdsvicqvhhha

QWPDMGVPEYSLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAILSK
 |  .  |  .||.. .. .    |.     | |    | ||. ..|     ..|..     ||.  .| |. ||   |..  ||  |.  ... |  |
pwkhlqqppktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyiark

0048076 (Phosphotyrosine protein) phosphatases II 1867-1988 7.8e-25 82.6 In-house 33-138 (145) alignment
Range on Protein: 1867-1988
Range on HMM: 33-138/145.0
VRNFtlrntkikkgSQKGRPSGRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAvGPVVVHCSAGVGRTGTYIVLDSMLQqiqhEGtVNIFGFLK
| |.          .   .   | ..||.|. |||.|||. .  .|.|..    | ..  |||.||||||||||||..... ||.    .| |...  |.
vlnl..........tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....lg.vsleeale

HIRSQRNYLVQTEEQYVFIHDT
..|||| . |....|. |... 
lvrsqrpgavpnpgqlrflyef

0048179 (Phosphotyrosine protein) phosphatases II 1884-1987 5.8e-24 79.9 In-house 48-139 (144) alignment
Range on Protein: 1884-1987
Range on HMM: 48-139/144.0
GrpsgrvVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAvGPVVVHCSAGVGRTGTYIVLDSMLqqiqHEGtVNIFGFLKHIRSQRNYLVQTEEQYV
       ..||... |||.|||...  .|.|..    | ..  |||.||||||||||||..... |.    ..| ....  |...||.| . |....|. 
e......giqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrpgavpnpgqlr

FIHD
|...
fLle

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1888-2034 5.7e-30 99.0 In-house 88-236 (440) alignment
Range on Protein: 1888-2034
Range on HMM: 88-236/440.0
GRVVTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRH-AVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIH
 |.. ||||  ||| |||... ||| ...    .. . . ||..||||||.||||  |..||.|.. ..   ..|| |.. .|..|  .||| |||.|.|
srtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

DTLVEAILSKETEVLDSHIHAYVNALLIPGPA-GKTKLEKQFQLLSQSN
....|..|. .| .|.  |   |. .  | |   |. |...|.  |. |
eavlegllcgdtliledditerveqiqwpnphtdksplqqefegyskkn

PTPc_DSPc_SM00012 1891-1990 5e-35 115.2 In-house 2-104 (105) alignment
Range on Protein: 1891-1990
Range on HMM: 2-104/105.0
VTQYHYTQWPDMGVPEYSLPVLTFVRKAAYAKRHAV--GPVVVHCSAGVGRTGTYIVLDSMLQQIQHE-GTVNIFGFLKHIRSQRNYLVQTEEQYVFIHD
|..||||.|||.||||.| ..|...|.    |...   .|||||||||||||||...|| .|||...| ..|.|| ..|..|.||. .|||||||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

TLV
 | 
all

0038934 (Phosphotyrosine protein) phosphatases II 1892-1946 2.8e-06 22.6 In-house 80-135 (194) alignment
Range on Protein: 1892-1946
Range on HMM: 80-135/194.0
TQYHYTQWPDMGVPEYSLPVLTFVRKA-AYAKRHAVGPVVVHCSAGVGRTGTYIVL
 .|.  ..|| |..     .|.|.. .  . .... | |.||| ||.||||| .. 
ieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa

subfamily_PTPDC1_pd Subfamily PTPDC1 1894-1987 5.5e-07 24.2 In-house 85-170 (182) alignment
Range on Protein: 1894-1987
Range on HMM: 85-170/182.0
YHYTQWPDMGVPEYSlPVLTFVRKAAYAKRHAvgPVVVHCSAGVGRTGTYIVLDSMLQQiQHEGTVNIfgflKHIRSQRNYLVQTEEQYVFIHD
..   |.| ||.     .|. |. .|.| ..    | ||| || ||||  |    . .. . ..   |    | .||.|   .|| ||  ....
vynfgwkDygvasle.riLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyak.rltaekai....klvrskrpksiqtreqvelvke

subfamily_CDC14_pd Subfamily CDC14 1908-1969 7.7e-06 20.0 In-house 245-304 (328) alignment
Range on Protein: 1908-1969
Range on HMM: 245-304/328.0
SLPVLTFVRKAAYAKRHAVGPVVVHCSAGVGRTGTYIVLdSMLQQIQHEgTVNIFGFLKHIR
| |  . |.|   .  .| | ..||| ||.||||| |    .... .   . .. ..|. .|
stPsdaivkkfleiaekaeGaiavhCkaGLGrtGtLiac.ylmkhyrft.aaeaiawlricr

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1920-1987 2.5e-07 24.3 In-house 259-338 (349) alignment
Range on Protein: 1920-1987
Range on HMM: 259-338/349.0
YAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQ--QIQHE----------GTVNIFGFLKHIRSQRNYLVQTEEQYVFIHD
| .   . ...|||||| ||||... ||..|.  .  ..              |.  . ..| ||  .||   |...|..
yldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiye

subfamily_CG42327_pd Subfamily CG42327 1921-1990 5.9e-15 49.7 In-house 242-312 (319) alignment
Range on Protein: 1921-1990
Range on HMM: 242-312/319.0
AKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHE-GTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLV
..|.  ||.||||| ||||||. |  |  ......   .|.|   . ..| .|   |.| ||| ||. .| 
gtresqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1927-1992 2.2e-13 44.7 In-house 229-294 (297) alignment
Range on Protein: 1927-1992
Range on HMM: 229-294/297.0
GPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEA
 ...|||||||||.|  .  | .|......   ..  .|...|.||  |||| ||. ...|  .. 
ayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk

subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1930-1993 1e-16 55.0 In-house 2-65 (69) alignment
Range on Protein: 1930-1993
Range on HMM: 2-65/69.0
VVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
|||||.| |||||.| .   . .|. |  |.||  ....|  |  .|  | .|.||||.||||.
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal

subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1930-1993 7.7e-16 52.2 In-house 1-64 (69) alignment
Range on Protein: 1930-1993
Range on HMM: 1-64/69.0
VVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQTEEQYVFIHDTLVEAI
|||||.| |||||.| .   . .|. |  |.||  ....|  |  .|  |..|.||||.||||.
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal

0051299 (Phosphotyrosine protein) phosphatases II 1998-2282 6.5e-72 237.7 In-house 3-285 (288) alignment
Range on Protein: 1998-2282
Range on HMM: 3-285/288.0
TEVLDSHIHAYVNALLipgPAGKTKLEKQFQLLSQSNIQqSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQ
||.  .... .|..||   . |.|.|...|. | . ...  ..||||...|.|||| |.|.| ..||| .|.|.| ||.|||||||| ||.....||.||
teisveellklvlkll...angltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatq

HPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA-EDEFVYWPNkDEPINCESFKVTLMAEEHkclsnEEKLIIQDFILEAT----QDDYVLEVRHFQCPKW
.|| .|..|||||.|..| ...||. . ...  |. . |||. ....... ..|||. ||.     ... ..  .... .    .|.....|.||....|
gPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwpl.ggsltygditvtllseev.....lddytvrtlevtnldlldgdgesrtvthfhytnw

PNPDSP--ISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
|. . |  ..  ....  ...  |...||..||  .|   .|||.|| .|..|||||. |||... |..  .|||..   |||.|.|...| .
pdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealley

0039614 (Phosphotyrosine protein) phosphatases II 2001-2284 7.5e-66 217.9 In-house 12-290 (297) alignment
Range on Protein: 2001-2284
Range on HMM: 12-290/297.0
LDSHIHAYVNALLIPGPAGKTKLEKQFQLLSQSNIqqsDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG--EGTDYINASYIMGYYQ-SNEFIITQH
 . .....  .||.  . .||.|...|. | . ..   ||| ||...|..||| ..|.| ..||| .... |  ...|||||||. ||.. ...||.||.
ipiplsvldlllllekansktllllefeellslkp...dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqg

PLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEpiNCESFKVTLMAEEHkclsnEEKLIIQDFILEAtqDDYVLEVRHFQCPKWPNPDSP
|| .|..|||||.|... . .||. .   .    . |||.. .  ... |.|||. .||     ..  ..  . ..   ......|.|||...||  . |
PlpetvedFwrmvweqgvtvivmLtklvelgrkcaqywpeegg..tygdftvtllkveh.....ldgytvrtlevtn..ngesrtvthfqytgwpdhgvp

--ISKTFELISVIKEEAA--NRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
  ..  .|..  ..|  |  ...||..||  .|   .|||.|. ....|||||  |||... |... .|||..   .||.|||...| |..
pslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk

0043336 (Phosphotyrosine protein) phosphatases II 2005-2281 1.1e-66 220.4 In-house 4-275 (278) alignment
Range on Protein: 2005-2281
Range on HMM: 4-275/278.0
IHAYVNALLIPGPAGKTKLEKQFQLLSQSNIqqSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTI
.. ...||| .....||.|...|. | . ..   .|| ||...|..|||...|.| ..||| .|.|.|. ..|||||||. || ....||.||.|| .|.
vkdllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

KDFWRMIWDHNAQLVVMIPDGQNMA-EDEFVYWPnkDEPINCESFKVTLMAEEHkclsnEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISK
.|||||.|... . .||. .   .  .  . |||  ....... |.|||. |||     ..  .. .. .. ..|.....|.|.....||  . |  .| 
edFwrmvwelgvttivmLtelvelgrvkcaqYwp..ggsltygdftvtllkeeh.....lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsl

TFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
 .... ...|  ....||..||  .|   .|||.|| .|..|||||  ||.... |... .||| .   .||.|||...| 
lldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle

0045450 (Phosphotyrosine protein) phosphatases II 2009-2283 9.7e-66 217.9 In-house 15-304 (307) alignment
Range on Protein: 2009-2283
Range on HMM: 15-304/307.0
VNALLIPGPAGKTKLEKQFQLLSQSNIQ-QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG--EGTDYINASYI--------MGYYQSNEFIITQH
. ..|.  . ..|.|.|.|. | . ...   .||.||...|..||| ..|.| ...|| .|||.|  |..|||||||.         ||.....||.||.
lllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatqg

PLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAE-DEFVYWPNKDEPINCESFKVTLMAEEHkclsnEEKLIIQDFILEAT-QDDYVLEVRHFQCPKWPNPD
|| .|..|||||.|... ...||. .   ..    . |||...|..... |.|||. |||     ......  . .. . .......|.||....||. .
PlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.....ldgytvrtlevtdldgtgesrtvthfhytgwpdhg

SP--ISKTFELISVIKE--EAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENS---VDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLV
 |  .. ....|  ...  |. ...||..||  .|   .|||.|. ....|||||.    ||.... |..  .|||..   |||.|||...| |.
vppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

0047943 (Phosphotyrosine protein) phosphatases II 2013-2281 4.1e-70 231.7 In-house 4-270 (273) alignment
Range on Protein: 2013-2281
Range on HMM: 4-270/273.0
LIPGPAGKTKLEKQFQLLsQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGIsslSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWD
|. .. |.|.|...|.|| .|.. . .||.||...|..||| ..|.|...||| .   ...|.|||||||. ||.....||.||.|| .|..|||||.|.
llekllgltllleefell.lslkplltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvwe

HNAQLVVMIPDGQNM-AEDEFVYWPNKDE--PINCESFKVTLMAEEHkclsnEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISKTFELISV
.|....||. . ...  |. . |||.. .  ..... |.|||. ||.     ..  ..  ..|. ........|.||....||. . |  ..  .|.| .
qnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.....kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefiel

IKEEAAN--RDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
...  ..  ..||..||  .|   .|||.|| .|..|||||. |||... |..  .|||..   |||.|||...| 
vrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealle

0036941 (Phosphotyrosine protein) phosphatases II 2013-2284 2.9e-69 229.0 In-house 5-278 (297) alignment
Range on Protein: 2013-2284
Range on HMM: 5-278/297.0
LIPGPAGKTKLEKQFQLLsQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGIsslSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWD
|.... ....|.|.|. | .... . ..|.||...|.|||| ..|.| ...|| .   ..||.|||||||. ||.....||.||.|| .|. |||||.|.
llekllflalllkefeel.lpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvwe

HNAQLVVMIPDGQ-NMAEDEFVYWPNK-DEPINCESFKVTLMAEEHKclsNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISKTFELISVI
.| . .||. .   .  |  . |||.. .|..... |.|||. .|..   ...  ..  . .. |.......|.||....||  . |  ..  ...|  .
qnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevv...llddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielv

KE--EAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLE---KENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
..  ......||..||  .|   .|||.|. ....|||   ||. ||.... |..  .|||..   |||.||| ..| |. 
rkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk

0050432 (Phosphotyrosine protein) phosphatases II 2014-2285 7.9e-72 237.5 In-house 35-301 (308) alignment
Range on Protein: 2014-2285
Range on HMM: 35-301/308.0
IPGPAGKTKLEKQFQLLSQSNIqQSDYSAALKQCNREKNRTSSIIPVERSRVGIsslsGEGTDYINASYIMGY--YQSNEFIITQHPLLHTIKDFWRMIW
. .. ....||..|. | .  .   .||.||...|..||| ..|.| ..||| .    .||.|||||||..||  .....||.||.|| .|..|||||.|
lekaldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgyssklprkfIatqgPlpntvedFwrmvw

DHNAQLVVMIPDGQNMA-EDEFVYWPNK--DEPINCESFKVTLMAEEHkclsnEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISKTFELIS
..| ...||. . ...  |  . |||..  ....... |.|||. ||.     ..  ..  ..|. ..|.....|.||... ||. . |  ..  .... 
eqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.....lddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldfle

VIKEEAanRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST
 ...    ..||..||  .|   .|||.|| .|..|||||. |||... |..  .|||.. . |||.|||...| ....
lvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylkl

0040438 (Phosphotyrosine protein) phosphatases II 2017-2286 2.2e-67 222.9 In-house 14-279 (317) alignment
Range on Protein: 2017-2286
Range on HMM: 14-279/317.0
PAGKTKLEKQFQLLSQSNIQqsDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNA
. ..|.|...|. | . ..   .|| |....|..||| ..|.| ..||| .|.|.| ...|||||||. |......||.||.|| .|. |||||.|... 
ksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgv

QLVVMIPDGQNM-AEDEFVYWPNkDEPINCESFKVTLMAEEHkclsnEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISKTFELISVIKEEA
...||. .   .  |  . |||. .|..... |.|||. ||.     ..  ..  . .| ..|.....|.||... ||  . |  ..  ..... ..|  
tvivmLteleelgrekcaqYwpl.getltygdftvtllseee.....lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavreal

ANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTR
....||..||  .|   .|||.|. ....|||||. |||... |... .|||..   |||.|||...| .. ..
edpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk

subfamily_PTPN23_pd Subfamily PTPN23 2017-2284 3.2e-42 139.3 In-house 11-281 (288) alignment
Range on Protein: 2017-2284
Range on HMM: 11-281/288.0
PAGKTKLEKQFQLLSQSNI-QQSDYSAALKQCNREKNRTSSIIPVERSRVGISslsGEGTDYINASYIMGYY-QSNEFIITQHPLLHTIKDFWRMIWDHN
. |||.|.|.|..| |..  .. . | |. ... ||||   |.| ...|| .    |.  ||||||.. .   .. .||.|| ||  |. |||.|...  
ldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr...gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

AQLVVMIPDGQNMAED-EFVYWPN-KDEPINCESFKVTLMAEEhkclsNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPN---PDSPiSKTFELISVIK
....||. . ... .     |||. |.|. . . ..|||  ..     . |. . ....||  . | | .|.| |  .||.   |.|| .. .... ...
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvr.....etethvervlkletldadavksvshlqltsWpelGvPasP.etllqfldeve

E--EAANR--DGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSV-DVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
.  || .|  . |..||   |   .|.|. . . ...|||.| . |. || . .   |  .  . ||..|.|...|  . 
sayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaar

0045098 (Phosphotyrosine protein) phosphatases II 2018-2284 5.3e-59 195.2 In-house 6-273 (278) alignment
Range on Protein: 2018-2284
Range on HMM: 6-273/278.0
AGKTKLEKQFQLLSQSNiqqSDYSAALKQCNREKNRTSSIIPVERSRVGisslsgegtDYINASYIMGYyqSNEFIITQHPLLHTIKDFWRMIWDHNAQL
 ....|| .|.||  ..   |... ||. .|..||| ..|.|...|||          ||||||||.||  ...||.||.|| .|. |||||.|... . 
sldlllefefllllgip...seitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitv

VVMIPDGQNM-AEDEFVYWPNkDEPINCESFKVTLMAEEHKclsneEKLIIQDFILEAT----QDDYVLEVRHFQCPKWPNPDSPISK----TFELISVI
.||. . . .  |  . |||. ....... |.|||. ||.      .. .. ..... .    .|.. ..|.|.... ||  ..| .      .||.  |
ivmltelvelgrekcaqywpe.ggsltygdftvtllseevl.....ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefi

KEEAAN-------------RDGPMIVHDEHGGVTAGTFCALTTLMHQLekENSVDVYQVAKMINLMRPG-VFADIEQYQFLYKVILSLVS
.|  ..             ..||..||  .|   .||..|. .....|  |. ||.... |..  .||| ..   |||.|||...| |..
realkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll

subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 2018-2287 3.7e-57 188.8 In-house 20-287 (319) alignment
Range on Protein: 2018-2287
Range on HMM: 20-287/319.0
AGKTKLEKQFQLLSQSNIQqsDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQ
.|.|.|||.|.||.... .  ... | |. |..||| . |....|.|| .|.| | ||.||||||.| || . ..|| || || .||.|||||.|.... 
tgetllekefkllkeavnd..tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeeess

LVVMIPDGQNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKclsneEKLIIQDFILEATQDDY-VLEVRHFQCPKWPNPDSPISKT--FELISVIKEEAA
 |||. . ..  . ..   ... .. .   . |||  ||..     |..||... |.  ...    || |||  .||. | | . |   .|.  |..   
ivvmltklveklkvklkkywpeenfeeyGrlivtleeeeel.....edyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirksre

N-RDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQ
.  .||..||   |    |||..|   . ....|. .||....... . |. .    |||.|.|...|  |.. .
ktqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagd

subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 2018-2295 1.1e-56 187.3 In-house 17-292 (318) alignment
Range on Protein: 2018-2295
Range on HMM: 17-292/318.0
AGKTKLEKQFQLLSQSNIQQSDYSAaLKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQ
 |...|..... ||.|. . . . . |...|. |||   |.. ...|| .. |.|| |.|||||.|| || .....| .| || .||.|||||.|. |..
sGelllseeyerlsrseetvtslks.lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsa

LVVMIPDGQNMAEDEF-VYWPNKdEPINCESFKVTLMAEEHKclsneEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKtFELISVIKEEAA-N
..||. . .. . .    |||.| .... .. .|.|. | .      ...... | .. |. . . .|| ... .||. ..| |   .|......  . .
vivmltqeeergkakvhryWPsk.gsrsygklvvelkeevel.....sdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesg.aslldlvrqvskaq

---RDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSL
     ||..||   |   .|.|.|. .|......|. |||.|. |..   |. .    .||.|.|.|.|  . . . |  .. |
qksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdl

subfamily_PTPN6_pd Subfamily PTPN6 2018-2288 3.4e-43 142.8 In-house 23-302 (306) alignment
Range on Protein: 2018-2288
Range on HMM: 23-302/306.0
AGKTKLEKQFQLLSQSNIQ-QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQ--SNEFIITQHPLLHTIKDFWRMIWDHN
 .|. .|..|. |.|.. . . . . . |. |.||||  .|.|.. .|| ... |  |.|||||.||..  .  ....| ||  | .|..|||||.|. |
lekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqen

AQLVVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEhkclsNEEKLIIQDFILE-ATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVIKE
....||.    . ...    |||.. |  .  . .|| ..|.     . .. |. .. ..  ....   ||....  .||. . | ..    .... ...
srvivmttkevErgkekCarYWPdeeekeeyGkisvtnvsek.....sladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnr

EAANR----DGPMIVHDEHGGVTAGTFCALTTLMHQLEKE---NSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQE
.. .      ||..||   |    |||  . .|....||.     .|.... |..   | |.    .||.|.||.|   . |...
kqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyietkkk

subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 2018-2292 2.2e-22 74.0 In-house 24-297 (310) alignment
Range on Protein: 2018-2292
Range on HMM: 24-297/310.0
AGKTKLEKQFQLLSQSNIQQSDYSAaLKQcNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQL
 |   | ||.. |   . .   | |  |. .  ||| | ..  . ||| .        ||| | |.   |  . || .| || ||| ||||||..  |. 
lgieglvkqyrkldakqdssltyea.ykk.ymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraes

VVMIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEHK--CLSNEEKLIIQDFILEATQDDYV--LEVRHFQCPKWPNPDSPISKTFELISviKEEA
....    .        |||           .|| ..|  .   . |    .. | .    |   .  | |   . |.||.   |  |   .    .  |
illlckvgeegrpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpq..rlla

ANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAkmINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPS
  | || .||   |    .. .||   ...|.. . ||. .|    .|..  .     . |.|.   . .. .| |.. .
qvrhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevk..tellksraiciqtelqyliidrvriifargeteva

subfamily_PTPRG_pd Subfamily PTPRG 2019-2297 4.4e-112 370.1 In-house 17-301 (563) alignment
Range on Protein: 2019-2297
Range on HMM: 17-301/563.0
GKTKLEKQFQ-LLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGT-DYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNA
|.......|. | |... .. |.... |..|..|||...|....|||| .|.|.| ... |||||.||.||..|..||.||.|| .|..|||||||..|.
gdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnv

QLVVMIPD-GQNMAEDEFVYWPNkDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQD-DYVLEVRHFQCPKWPNPDSPISKTFELISVIKEEAA
...|||..  ........||||. ||........|||..||...|.....|.|....|..... |....||.....|||....| .....|| |.|..||
aiivmitnlvergrrkcdvYWPk.desetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkssaa

NRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDS
|..  ||..||...|....||...|.||..|...||.|.|....|.|...|. .....|||.||....|........|  .. ...
nkaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqvee

subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 2019-2286 4.1e-49 162.2 In-house 19-282 (288) alignment
Range on Protein: 2019-2286
Range on HMM: 19-282/288.0
GKTKLEKQFQLLSQSNIQQSDYSaALKQCNREKNRTSSIIPVERSRVGISSL-SGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQL
..| ...... |.. . ..|.   . .  | .|||   |.|..  || .  |  ..|.|||||||| |. .....| || || .|..|||......... 
nrtgfseeynsLaalektksvta.grlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenktst

VVMIPDG-QNMAEDEFVYWPNKDEPINCESFKVTLMAEEhkclsNEEKLIIQDFILEatQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVIKEEAAN
.||. .  ..  .    |||..|.| |  |..|||. ..     ..|. . . ..||  ..   ||. ..|   ||. . | ||.  .||.. .|    .
ivmltelveggktkCeeYWPdadkpknyGsvtvtlvesk.....eledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqa

RDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTR
  ||.|||   |   .||| || .|....|.|. .||  . . .   |. .    .||.|.|.|.|||.. .
dtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevllslieed

subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 2019-2285 8.6e-47 154.5 In-house 18-280 (287) alignment
Range on Protein: 2019-2285
Range on HMM: 18-280/287.0
GKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISslsGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV
|..  ..||..| | . .. .   .. . |..||| . |.. .  || .    ||  |||||..| || ....|||.. |. .|...||..|.|.| . .
gnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk...gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtai

VMIPDGQ-NMAEDEFVYWPNKDEpINCESFKVTLMAEEHKCLSNEEKLIIQDfileATQDDYVLEVRHFQCPKWPNPD---SPISKTFELISVIKEEAAN
||. . . |  |  . |||...  .    ....|. ||..    | || ..      ....  ..|. .|  .|..     .| .  . .   .|..  .
vmlcqekendeevcyqyWpeeks.vvlGeyniellneevnagyierklevkn....knkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkr

RDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST
 .....||   .   ...|||  | ... ..|  .||.|| |     .||    .|||.|.....|  ...
gntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds

subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 2019-2285 1.1e-43 144.1 In-house 18-285 (290) alignment
Range on Protein: 2019-2285
Range on HMM: 18-285/290.0
GKTKLEKQFQLLSQSNiQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGT---DYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNA
|... ..||. | ... ..     .| . |...|| . |.. .  |. .  .||.     .||||.|| || .....|.|| |. .|..|||..||... 
gnegfrnqfkmldsge.sehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliwqekv

QLVVMIPDGQNMAED-EFVYWPNKDEPInCESFKVTLMAEEHKCLSNEEKLIIQDfileATQDDYVLEVRHFQCPKWPNPD---SPISKTFELISVIKEE
  .||. . ... ..    |||..|     . |...|. ||.     | || ...     .....  .| ..|   |.. .    | . .  .  ..| .
tiivmltniieegkvkCqqYWpdsdtka.ygefsikllneetlneyierklevkn....knsagakqsvtqyqitnwdstgkvtnpqtillvieemyktq

AANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST
  . .....||   .   ...|||..| . . ..|  .||.|| |     .||     .|||......|. ...
rkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds

subfamily_PTPRN_pd Subfamily PTPRN 2019-2280 2.6e-29 96.9 In-house 27-289 (297) alignment
Range on Protein: 2019-2280
Range on HMM: 27-289/297.0
GKTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLS-GEGTDYINASYIMGYY-QSNEFIITQHPLLHTIKDFWRMIWDHNAQ
 |..|||... | . . ..|  ..| .. | .|||.....| . ||| ... .  | .|||||| |.    ..  .| || || .|. |||.|.|.. . 
nkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvv

LVVMIPDGQN-MAEDEFVYWPNKDEPINcESFKVTLMAEEHKClsneEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVIKEEAA
..|..   ..   . .  |||.. . .  . ..| |..|   |    .  ... | |   | .    |  |    ||. . | |    .|.   .     
vivnltrleeegvkqckrywpdeGsevy.hiyevhlvsehiwc....ddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyr

NRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKE-NSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
 |  |..||  .|   .|.....  ....| |  . .|.    . .   |||. .  .|..| .... 
GrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltava

subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 2019-2288 1e-20 68.9 In-house 14-282 (307) alignment
Range on Protein: 2019-2288
Range on HMM: 14-282/307.0
GKTKLEKQFQLLSQSNIQQSDYSAalKQCNREKNRTSSIIPVERSRVgISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV
| ..|  .|. |.. . .     |   ..| .||| . .  ....|. .  ..|  .||| | |.    . . || .| ||  |. .|| |. ... . |
gvqalvdefrvlakktpegvtvea..fsantdknryqdvkcqdkgri.vvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VMIPDGQNMAEDE-FVYWPNKDEPINC---ESFKVTLMAEEHKCLSNEEKLIiQDFILEATQDDYVLEVRHFQCPKWPNPDSPISkTFELISVIKEEAAN
.|. .  ..|.     ||| ..   .    ..  ...     | |. .|.|| .   |.    .    ..|.|  .||.   |    .  | ...    .
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedli.nvttlkvdwaqksrtiqhlqwenwpdrgvpqi.nltainlleavryd

rDGPMIVHDEHGGVTAGTFCALTTLMHQ-LEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQE
   |..||   |   .||  |.. .. . .. .|  |. .. . .   |.    .  || .|..|.|.    .  
.tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyflelyk

subfamily_PTPRD_pd Subfamily PTPRD 2020-2297 1.8e-68 226.5 In-house 22-295 (564) alignment
Range on Protein: 2020-2297
Range on HMM: 22-295/564.0
KTKLEKQFQLLSQSniQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV
..|.|.... ....  ||.  .|| |..|..||| . |.. ..||| .|.. | ||.||||||.| || .....| ||.|| .||.|||||.|..| . .
dlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnssti

VMIPDGQNMAEDEF-VYWPNKDePINCESFKVTLMAEEHKclsneEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVIKEEAANR
||.   . . ....  |||.|. . ......|||..||..     .. .| .|.|. .... . |||.|.  .||. . | | |   .||. ... . . 
VmltkleEkgkvkchkYWPekg.tetygeltVtleeeeel.....adyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepd

DGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDS
 ||..||   |    |||...  .. ....|. ||.||. |..   |. .    |||.|....||  ..  ..| .| .| .
agPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkq

subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 2020-2286 1.4e-56 187.0 In-house 26-293 (298) alignment
Range on Protein: 2020-2286
Range on HMM: 26-293/298.0
KTKLEKQFQLLS--QSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISS-LSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQ
 |.....|| |.  .|.|..  ...| |. |..||| ..||... ||| ...  . | .||||||.. .| ..| ||.||.|| .|..|||||.......
ltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFWrmvteedig

LVVMIPDGQNMAE-DEFVYWPNKDEpINCESFKVTLMAEEHKClsneeKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVIKEeAA
 .||. . ... . .   |||.. .  . ....|.|...|..      .||.. .... .. .   |||...  .||. . |  .|  ..|.. ..    
tiVmltnleeldktkyhkywPdegk.etygeitvsllskeefa.....dlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sq

NRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTR
..    |.||.  .|   .|||.|. ... ...||..|||.|| |..   |||.    ||| |.|...|  ... 
qqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf

subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 2020-2287 7.1e-48 158.3 In-house 21-287 (305) alignment
Range on Protein: 2020-2287
Range on HMM: 21-287/305.0
KTKLEKQFQLLSQSniqQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV
...||.|...| .    .. .    |. |..|||...|.. . .|. ..  . .. .|||||||. || .....|..| || .|..||||.|..   . .
dkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvsti

VMIPDGQNMAEDE-FVYWPNKDEP-INCESFKVTLMAEEHKclsneEKLIIQDFILEA-TQDDYVLEVRHFQCPKWPNPDSPISKTfELISVIKE--EAA
||. . ..  .|    |||..     . ..|.|.|  |..      . .|. .. .    .|.    | ..|  .||.   | . |  |.|.||.  .. 
vmltklveggkdkCrqYWpesktekkefgefsvelksekta.....sdyieRklkisiededkesrtvlqyqltdWPdhGvpqfat.sllslikrvqkdq

NRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQ
..|   |..||   |   .|.|.|.   . .|.||..|||..| | .   |...    .||.||. ..  |. . .
kkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgd

subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 2020-2281 1.2e-44 147.9 In-house 33-289 (319) alignment
Range on Protein: 2020-2281
Range on HMM: 33-289/319.0
KTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV
.|||| .|. ...  .. .| . |  . |..|||   |.. ....| .  | | |..||||||.. || . . .| .| ||  |..|||||||..|.  .
ltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncsti

VMIPdgqnmAEDEFVYWPNKDEpINCESFKVTLMAEEHkclSNEekLIIQDFILEA-TQDDYVLEVRHFQCPKWPNPDSPISkTFELISVIKE-----EA
|..       .    |||.| . |. | ||| . . |    ..|   ...|. |   ..   . ... |    ||.   | . . .|. ..|      . 
vllt.....kdkcsqywplkiv.ikeerfkvkvdsvee...tae..yvvrdielsedgkekdirkitqfhflGwpdvGvpdy.psdlmrlvkkvrhltsk

ANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
 |   ...||   |   .|.. .| .|......|. ||||.. . .   |. .  |. ||.|.|  .| 
enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_PTPN9_pd Subfamily PTPN9 2020-2283 2.9e-37 123.3 In-house 15-290 (297) alignment
Range on Protein: 2020-2283
Range on HMM: 15-290/297.0
KTKLEKQFQLLSQSNIQqSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLV
|  | |... . . ...   . |. ...| |||| . .. ....|| ...... | .|||||... || | . || || || .|..|||||.|....  .
krGlskeyaeirnepve.GtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvi

VMIPDGQNMAEDE-FVYWPNK-DEPINCESFKVTLMAEEhkclsNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISK--TFELISVIKEEA--
||.    ..       |||.. .. ..  ...|. .  |     .||.  .. . .. ....   .| |||   ||.   | |    ........|.   
vmttrvvergrlkcgqyWpleeessaefgdlsvsnveve.....eeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqal

-----------ANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLV
             .. |..||   |   .|||..|   . .||... ||| .. |..   |       |||.| |. .|   
avkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya

subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 2020-2285 2.7e-33 109.9 In-house 14-295 (301) alignment
Range on Protein: 2020-2285
Range on HMM: 14-295/301.0
KTKLEKQFQLLSQSNIQQSdySAALKQCNREKNRTSSIIPVERSRVGISS---LSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQ
..|.|.|.. |.. . ...  .  |.. |.. ||  .| ...  |. ..    |.   ..||||||| || ....||..| |. .|..||||.||..  .
snkfeeqykelkegedksc..tvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqekpv

LVVMIPDGQNM-AEDEFVYWPN-KDEPINCESFKVTLMAEEH--KCLSN----------EEKLIIQDFILEATQddYVLEVRHFQCPKWPNPDS---PIS
 .||. . ..   .  . |||| . |  .   |.|||. |      .            ... |.. |  ....     .|  .|  .||.      |  
sivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk..sswdvlqlqvtdWpqdGvvreprt

KTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVST
    .  ||. .     ||..||   .   .|..|...  . |   |  |||.|| | .   .||.   .||| ..|.||   .. 
vLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql

subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 2020-2280 2.6e-29 97.1 In-house 5-256 (267) alignment
Range on Protein: 2020-2280
Range on HMM: 5-256/267.0
KTKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEgtdYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVV
....||.|.|. .   ..|  |  . . |.|.||    .| . .|| ..    |   ||||||. ||.. | ||.|| ||  || ||. .| |..   .|
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee...yinasyvegyktknafivtqdplkntitdfltvihdqkvpviv

MIpdgQNMAEDE-FVYWPNKdepiNCESFKVTLMAEEHKCLSNEEKLIIQDFILEAtQDDYVLEVRHFQCPKWPN--PDSPISKTFELIsVIKEEAANRD
..   ..  .|.   .|| |      .. |   .. ||    .|.   |  . |.  ...   .|  .   ||     . |  | .  | . |..  | .
ll...tkvftdnirlfwPPk....mgqakkyqdltvehslekeendyqiitlelkf.knesahnvtlyyykkwnintnnkpylkplfgi.laknqlengn

GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
 |..|. . |  ..|||  . . .... .|. .|...  . |   |.|.    |.| ...... 
rPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihella

subfamily_PTPRB_pd Subfamily PTPRB 2021-2289 6.3e-50 164.9 In-house 25-291 (293) alignment
Range on Protein: 2021-2289
Range on HMM: 25-291/293.0
TKLEKQFQLLSQSNIQQSDySAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVV
... .... |.. . .|.  .|| ...||.||| . |.| . ||| ...|.. .|.|||||.|| || . .||| || || .|..|||||.|..... .|
lrfseeyeelkavgkdqav.kaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekkssiiv

MIPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEEHKclsneEKLIIQDFILEAtqDDYVLEVRHFQCPKWPNPDSPiSKT---FELISVIKEEA--A
|. .  .        |||...||..  . ||||.|||..     |. .|... .|   ..   .||...   ||. . | .||    ...  ..|..  .
mltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeel.....edwvirelkiek..ekeerkvrqyhftsWpdhgvP.ektktlldfvrtvreaiekt

NRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEE
....|..||   |   .||| || .|....|.|. ||.. .   .   |  .    .|| |.....|.|.....||
askrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllrkkeee

subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 2021-2280 1e-37 124.6 In-house 6-263 (283) alignment
Range on Protein: 2021-2280
Range on HMM: 6-263/283.0
TKLEKQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGegtDYINASYIM---GYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQL
.. . ... | . .. . |   |  . |..|||   |.|... || . |.|    |||||..|.    | |....||.| || .|..|||.|..|...  
nnnklfrevlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr...dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekita

VVMIPDGQNMAEDE-FVYWPNKDePINCESFKVTLMAEEHKclsneEKLIIQDFILEAT--QDDYVLeVRHFQCPKWP--NPDSPISKTFELISVIKEEA
.||.   |.  . .   |||..   ..   | |||  |  .     . .||. ..|       . .| . |.|   |   .....|     .  ||    
ivmltklqedlrikCsqyWPkrG.sedyGeftvtlrketts.....nsfiikelllrvnssakstll.lahyqvidWleygeqaiinslvkfnkvislqt

ANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
 ...||..||   |.  ...|.|... ....  |  |||..| |..   |...    .||.......|
eskkgPivvhCstgiGrtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvl

subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 2021-2286 3.6e-13 43.6 In-house 26-288 (302) alignment
Range on Protein: 2021-2286
Range on HMM: 26-288/302.0
TKLEKQFQLLSQSNIQQSDySAALKQcNREKNRTSSIIPVERSRVgisSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTI---KDFWRMIWDHNAQL
....|.|. ...  ..      | |. | .||..  .  ..  .|    |..|  .|.||| .     ... |..| | . .     .||||..... . 
aevkkefkkidtmkvdlek.Ckafkk.nlkknqsedvpildsnlv...kleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivs

VVMIPDGQNMAE--DEfvYWPNKDEPIncESFKvTLMAEEHKCLSNEEKLiiQDFILEATQDDY----VLEVRHfqCPKWPNPDSPISKTFELISVIK--
||..   ... .  .|  ..|.| .    . .. ...    |  . ||.   . ...|   ...    . .| .  .  |..   |.. .    .. |  
vvilvgeeelkktlse..lfpkksgdy..keyg.kmfvNnrkVekaeeek..tryviEvlPegcsnsvlanvyv..ltnWkqkkvpvkyaeliktaakvf

EEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTR
.. .. | ....  ..|   ||.| .|.. ...|.|.. . . ...| |   || .   ..|| .|| ..| .. ..
akkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyikkk

DSPc_SM00195 2022-2283 5.4e-64 211.4 In-house 1-262 (263) alignment
Range on Protein: 2022-2283
Range on HMM: 1-262/263.0
KLEKQFQLLSQSNIQQsDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVM
||...|. | .|. .. . . | |. |..||| . |.|....|| ...  . ||.|||||.|| |. .....|.||.|| .|..|||||.|... ...||
klkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

IPDGQN-MAEDEFVYWPNK-DEPINCESFKVTLMAEEHKClsneEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISKTFELISVIKEEAANRD
. . .    |    |||.. ... . ....|.|. .|.|     ...|.... |......   .|...|. .||. . |   ....||....|..  . .
lteeeengkekcdrywpeesggketfgkisvklvevekkk....deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstss

GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLV
||..||   |   .|||... .....||.|. ||. .. |..   |||..   |||.|.|..|| ..
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

PTPc_SM00194 2022-2283 5.4e-64 211.4 In-house 1-262 (263) alignment
Range on Protein: 2022-2283
Range on HMM: 1-262/263.0
KLEKQFQLLSQSNIQQsDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVM
||...|. | .|. .. . . | |. |..||| . |.|....|| ...  . ||.|||||.|| |. .....|.||.|| .|..|||||.|... ...||
klkeefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivm

IPDGQN-MAEDEFVYWPNK-DEPINCESFKVTLMAEEHKClsneEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISKTFELISVIKEEAANRD
. . .    |    |||.. ... . ....|.|. .|.|     ...|.... |......   .|...|. .||. . |   ....||....|..  . .
lteeeengkekcdrywpeesggketfgkisvklvevekkk....deiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstss

GPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLV
||..||   |   .|||... .....||.|. ||. .. |..   |||..   |||.|.|..|| ..
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi

subfamily_Ptp69D_pd Subfamily Ptp69D 2022-2284 2.8e-49 162.9 In-house 23-287 (307) alignment
Range on Protein: 2022-2284
Range on HMM: 23-287/307.0
KLEKQFQLLSQSNIQQsDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVM
 |.| .. | ...|.. . ... |. |  |||   |.. .. || .. . |.  .||||||.| || ....||. | |.  ||.||||||.. . .|.||
glakeyekLeareidk.stkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqevtlivm

IPDGQNMAED-EFVYWPNKdEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISK--TFELISVIKEEAANRDG
. . ... ..    |||.  . .. ..  |.|. ||..    . .| .     |... .   .|  ..   |..   | .    ..||. ..|   .  .
lsnlteknrkkcakYWpie.devqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllklieqvrelyklnrs

PMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
|..||   |   .|.| ||. |..||..|..||.... | .   |. ..  .|||.|||. .|   |
PivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyss

subfamily_PTPN12_pd Subfamily PTPN12 2022-2286 1.1e-44 147.5 In-house 9-280 (290) alignment
Range on Protein: 2022-2286
Range on HMM: 9-280/290.0
KLEKQFQLLSQSNI---QQSDY--SAALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNA
...|.|| | . .    ... |  .|. |. |..|||   |.| . ||| .|  ..|   |||||..| | ... |.| .| || .|..|||||||..| 
efakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknv

QLVVMIPDGQNMAEDEF-VYWPNK-DEPINCESFKVTLMAEEHKclsnEEKLIIQDfiLEATQDDYVLEVRHFQCPKWPNPDSPISK--TFELISVIKEE
..|||.    ...      |||.. .|... ..|.|||..|..     .. ..|.   |......   .|. |.  .||. . | |.   .|||. ..| 
eivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekav....dddflirt..LkveaqkesrkvyqfhYtaWPDhgvPssaksllelielvrel

AANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENS---VDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTR
  . | |..||   |   .|| .|.    ..|..|.    .||...   .   |. .    |||...|| ...||...
qesedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqke

subfamily_ptpA1_pd Subfamily ptpA1 2022-2245 4.2e-25 83.3 In-house 22-258 (418) alignment
Range on Protein: 2022-2245
Range on HMM: 22-258/418.0
KLEKQFQLLSQSnIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLS-GEGTDYINASYIMGYYQsNEFIITQHPLLHTIKDFWRMIWDHNAQLVVM
|....|.|| .| .  |. |   |. |  ||| . |.||...|| .  .   ||.||||| || | |  ..|| || ||  || |||||.|.  ....||
kikeefrllees.vgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgayp.kqfictqgplpntiadfwrmvwenrcriivm

IP-DGQNMAEDEFVYWPNKdepINCESFKVTL---------MAEEHKCLSNEEKLIIQDFIlEATQDDYVLEVRHFQCPKWPNPDSPIS-KTF-ELISVI
.  . .|       |||..   |  | | .             |  . . . |. ||   |   | .    .. ..|   ||. . |   . | .|.  |
lsresencrikcdrywpeq...iggeqfsiygngnevfgtysvelveviqdpereiitrni.rltfegetrditqyqyegwpdhnipdhtqpfrqllhsi

KE------EAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEK
 .       ...|. |.|||   |   .||||.   .|..|..
tnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldh

0046845 (Phosphotyrosine protein) phosphatases II 2023-2284 1.9e-69 229.6 In-house 2-275 (284) alignment
Range on Protein: 2023-2284
Range on HMM: 2-275/284.0
LEKQFQLLSQSNIQQS-DYSAALKQCNREKNRTSSIIPVERSRVGISSLSG--EGTDYINASYIMGY-----YQSNEFIITQHPLLHTIKDFWRMIWDHN
||..|. | . .. .. ..|.||...|..||| ..|.| ..||| ..||.|  |..|||||||. ||     |....||.||.|| .|..|||||.|..|
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

AQLVVMIPDGQNMA-EDEFVYWPNKDEPINCESFKVTLMAEEHkclsnEEKLIIQDFILEATQ-DDYVLEVRHFQCPKWPNPDSP--ISKTFELISVIKE
....||. .  ..  |  . |||...|..... |.|||. ||.     ..  ..  . |. .. ......|.||....||. . |  ..  .|..  ..|
vrvIVmltelvengrekcaqYwplegevltygdftvtllseev.....kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvre

EAA--NRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKEN---SVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
     ...||..||. .|   .|||.|| .|..|||||.    |||... |..  .||| .   |||.|.|...| ...
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk

subfamily_PTPRA_pd Subfamily PTPRA 2023-2283 1.4e-51 170.3 In-house 34-295 (330) alignment
Range on Protein: 2023-2283
Range on HMM: 34-295/330.0
LEKQFQLLSQSNIQqSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMI
. ..|. |  ..|| . . .| |. |.||||   |.| . ||| .| ..|.  .||||||.| || . ..|| .| |. .|..|||||||..... .||.
freefnalPagpiq.atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativml

PDGQNMAEDE-FVYWPNKDePINCESFKVTLMAEEHKCLSNEEKLIIQdFILEATQDDYVLEVRHFQCPKWPNPDSPISK--TFELISVIKEEAANRDGP
 . ..  |.    |||..   .     .|..  |.        |...|  . .||... .  || |    ||.   |.     ..|.  .|.   .  ||
telkerkeekcaqywPdeG.lvtyGnirvevedetvlvdytvrkflvq.qlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsagp

MIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLV
..||   |   .|||..| ....... |. |||... | . | || .    |||.|.|||.|   
ivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyy

subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 2023-2281 2.5e-41 136.6 In-house 7-266 (274) alignment
Range on Protein: 2023-2281
Range on HMM: 7-266/274.0
LEKQFQLLSQsNIQQSDYSAAlkqCNREKNRTSSIIPVERSRVGISSLSGEG--TDYINASYIMGY-YQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVV
|||.|  |   | .| ... .    . .|||  .|.| |.||| ..| |.|   ..|||| || || ..|. .. || || .|..||||||. ...|..|
lekeflelPl.nfdqeeldvf...gsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqviv

MIPDGQNMAE-DEFVYWPNKDEP-INCESFKVTLMAEEhkcLSNEEKLIIQDFILEATQDdyVLEVRHFQCPKWPNPDSPIS--KTFELISVIKE---EA
|. . ... |    ||.|.. .  |. .  .| .  |.     ....  .. ..|. ...    .| |.  ..||. .|| .  . ..|.  ..|   |.
mltklkeaneqkCavyfPdaedyeiserygdveikvek...iverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreee

ANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
... .|..||   |   .| | | .  ..||..|. ||| ..   . | | |.    |||.......  
naklapvvvhCsaGiGrtGcfiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralcl

subfamily_egg_pd Subfamily egg 2023-2281 2e-22 74.3 In-house 16-268 (307) alignment
Range on Protein: 2023-2281
Range on HMM: 16-268/307.0
LEKQFQLLSQSnIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMI
||.....| .| ...  .  |... |.|| |.  .   . ||| .    |    |.| | .. |    ||||..| ||  | .|||||..  . | .||.
lerrlevlees.vdeislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivml

PDGQNMAEDEFvYWPNK-DEPINC--ESFKVTLMAEEHKClsnEEKLIIQDFILeATQDDYVLEVRHFQCpKWPNpDSPISKTFElisVIKeEAANRDGP
   ..  . |. |||.  ....     |.... .  ..|    .  . .  . |    ||  . . |.|   . |  | .   ..   |..  . |   |
tsrkesercey.ywpkaesdslvtvpGslrienlkvdska...dplfrvtklkl.vGgddeerflehwqg.dvnn.ssdvysplr...vlr.klrnlskp

MIVHDEHGGVTAGTFCALTT-LMHQLEKE-NSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
..|.|  |   |.|. |. . |.. |        | .  ... | |.     . .| |.|...| 
vvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvlf

subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 2023-2282 8.1e-07 23.0 In-house 21-275 (312) alignment
Range on Protein: 2023-2282
Range on HMM: 21-275/312.0
LEKQFQLLSqSNIQQSDYSAALKQcnREKNRTSSIIPVERSRVgisSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIP
| |... .    ...|. .| ||   .. ||   |   .| |    .|.|.   || | ..    . . |..|| ||  |.  ||..     .  .... 
ltkeykavg.nivsdsectaflkf..kdlnrypniqcwdrgrf...tlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillc

DG-QNMAEDEFVYWPNKDEPINCESFKVTLMAEEHKCLSNEEKLIIQ----DFILEATQDDYVLevRHFQCPKWPNPDSPIS--KTFELISVIKEEaanr
   .. .|    |  .    .. |  .|         .    |  |       .. || ..  |   |.|   ||.   | |   .. |.| .| .    
gfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithrvlkvvvkatgqeskl..nhyqwaswpdhgmpdscdtalrllsavkkd....

DGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
  |.| |   |   .||.. . ...  | .    .| ..  ..   |      . || .  ...| .
kkpviahcsagvgrtgtlaliesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlef

subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 2024-2287 9.2e-39 128.3 In-house 29-288 (297) alignment
Range on Protein: 2024-2287
Range on HMM: 29-288/297.0
EKQFQLLSQSNIQQSdySAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQsnEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIP
...|. | ..|||..    | |. | ||.| . |.|...||| . ..  .   ||.|||.. |. .  ..| || |   |..|||.|..|.... .||. 
seeflclpeaniqpq..tvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmln

DGQNMAEDEFVYWPNKDEpINCESFKVTLMAEEHKCLSNEEKLIIQDfileaTQDDYVLEVRHFQCPKWPNPDSPI----SKTFELISVIKEEA-ANRDG
| ..  .    ||..|    .  .  |.|.. ....   . .| ..       .      |. .|  .||. . .     |.  .||| ....   | .|
ddnerdkkcaryWsdkgv.ttfGdvsvvllsvsereGfikrelevtk.....gkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg

PMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQ
|..||   |   .| ....   . . ..|..||.... |..   || .    |||.|.|...|  ... .
PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsed

subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 2024-2284 2.9e-37 123.3 In-house 18-277 (281) alignment
Range on Protein: 2024-2284
Range on HMM: 18-277/281.0
EKQFQLLSQSNIQQSDySAALKQCNREKNRTSSIIPVERSRVGISS-LSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIP
 .... |.. .....  .|. .. |..||| | |.  . .|| ..   . . ||||||... || . .|.|.|| |. .....||.|.|.......||. 
ieeyeklaaigvdnta.taskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvt

DGQNMAE-DEFVYWPNKDEPINCESFKVTLMAEEHkclsnEEKLIIQDFILeATQDDYVLEVRHFQCPKWPNPDSPISkTFELIS----VIKEEAANRDG
   .        |||.... ..   ..|. .|||.     ... | . | |  ...    ||....  .||.   | . | ||..    | | .  ... 
reieagklkChrYWPddnselkygdvtvkstaeee.....katyierkfkl.eresgetreveqlaytaWPdhGvPat.tkellefrkevlkltekktka

PMIVHDEHGGVTAGTFCALTTLMHQLEKE-NSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
|...|   |   .||. || .|....|.| ...|| .| . .   |  .   . ||.|.||..|  ..
plvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald

subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 2025-2303 7.3e-37 122.2 In-house 27-308 (325) alignment
Range on Protein: 2025-2303
Range on HMM: 27-308/325.0
KQFQLLSQSNIQqsDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPD
..|.||   . .   . .| |  |..|||   ......||| . ..  .. .|||||||.  . . . |. .| || .||.|.||.. | .. .||..  
hefgllpsddgi..akkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvvlne

GQNMAEDEFVYWPNK-DEPINCESFKVTLMAEEHKclSNeekLIIQDFILEATQDDYVLEVRHFQCPKWP---NPDSPIS--KTFELISVIKEEA---AN
 ..  .   ||||..  .  .  ...| |.. |.   |.    . . . .  ...   . |. ||   |.   ..  | .     .|.  ..|     ..
ldlgkdrcavywpkemgksktfGglevklrtieei..sd...yvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantk

RDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQEENPSTSLDSNGAALP
  .|..||   |   .|.| .| ... .. .| .||.... | .   || .   ..|| ..|. .   . . . . | .|.... ..| 
astpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssfeaklsslq

subfamily_PTPN3_pd Subfamily PTPN3 2025-2282 4.3e-34 112.7 In-house 19-274 (280) alignment
Range on Protein: 2025-2282
Range on HMM: 19-274/280.0
KQFQLLSQSNiQQSDYSAALKQCNREKNRTSSIIPVERSRVgisSLSGEGTDYINASYIM----GYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVM
.||. | . . .. . ||| |  | .|||   |.| .  ||   .|. . ||||||.|.     .  ..| .|.|| || .| .|||.|.|.....|.||
aqfeqlyrkk.pglaisaarkpenlsknryrdilpydatrv...klkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivm

IPDGQNMAEDE-FVYWPNKDEPINCESFKVTLMAEehkclSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISK--TFELISVIKEEAANRDG
. .  .        |||.... ..  .|.|..  |     ..... ......|. .. .   .. ..|   ||. . | ..   .|... ...  . .. 
lttlverGrvkChqyWPetedeleygefsvkceke.....detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkee

PMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
|..||   |   .| . .| | .. .|....| . .. ...   |  .    .||.|. . || .
PvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv

subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 2025-2178 1.5e-14 48.5 In-house 24-190 (350) alignment
Range on Protein: 2025-2178
Range on HMM: 24-190/350.0
KQFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGIS---------SLSGEGTDYINASYIMGY----YQSNEF--IITQHPLLHTIKDFWRM
 .. | |.|. .. |.  .       ||| . |.| |.||| .            | .. |||||.|.        .  .|  | || ||  |..||...
srlsLesdsespsnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykv

IWDHNAQLVVMI-PDGQNMAEDEFVYWPNKDepINCESFKVTLMAEeHKCLSNEEKLIIQDFILEATQDD
|   . ...... .|  .  |    ||.. .  ..    |.. . |   .  |.  |   |   ||...|
illnkvkvilsltsdvelnlekcyrYWqegs..ydditvklaskwe.nimgindsslysadvkkeasdnd

subfamily_CG7180_pd Subfamily CG7180 2026-2284 7.5e-45 147.8 In-house 20-291 (296) alignment
Range on Protein: 2026-2284
Range on HMM: 20-291/296.0
QFQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDG
. .|   ..... |  ..|.. ||||||   ..| .  || ...| ||  .|||||.|. .. . .|.|.|. |  .|...|||...|.... ||.. . 
klelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisavvvLtkt

QNMAEDEFVYWPNKDePINCESFKVTLMAEEHKCLSNEEKLIIQDF--ILEATQDDYVLEV---RHFQCPKWPN-PDSPIS--KTFELISVIK---EEA-
 ..|.    |||||    .   . | .. |..    .  .. ..     | ... . . |.   ..||  .|.     |.|     ||.  ..   |.. 
fdfakmypsywpnks.keqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvd

-ANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
  .  ||..|. . |.  .| ..|.   . ..|||. |||.. .|..   ||..   .|.|...| |.|  | 
edpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavl

subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 2027-2281 6e-43 142.4 In-house 4-253 (284) alignment
Range on Protein: 2027-2281
Range on HMM: 4-253/284.0
FQLLSQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPdgq
|. ...  .. .| . |  . |..|||   |.. ....| .  | | |..||||||.| || . . .| || ||  |..|||||||..|.  .|..    
frracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt...

nmAEDEFVYWPNKDEpINCESFKVTLMAEEHkclSNEekLIIQDFILEA-TQDDYVLEVRHFQCPKWPNPDSPISkTFELISVIKE-----EAANRDGPM
   .    |||.| . |. | ||| . . |    |.|   ...|. |   ..   . ..| |    ||.   | . . .|. ..|      .  |   ..
..kdkcsqywplkiv.ikeerfkvkvdsvee...see..yvvrdielsedgkekdirkirqfhflgwpdvgvpdy.psdlmrlvkkvrhltskenhrani

IVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
.||   |   .|.. .| .|......|. ||||.. . .   |. .  |. ||.|.|  .| 
vvhcsagvgrtgvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle

subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 2027-2282 1.8e-27 90.8 In-house 26-235 (392) alignment
Range on Protein: 2027-2282
Range on HMM: 26-235/392.0
FQLLSQSNIQQSdySAALKQCNREKNRTSSIIPVERSRVGISSLS-GEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQ
|. | . .| .   ..| |. | .|||   |.| ...|| .  .     .||.||||| .. . . .| .| |   ...|||||....|.  ..|. . .
fhdlpgpdiypq..tvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklk

NMAedefvywpnkdepincesfkvtlmaeehkclsneekliiqdfileatQDDYVLEVRHFQCPKWPNPDSPiSKTFELISVIKEEAANR---DGPMIVH
.                                                 . | .  |  |.  .||. | |  .|  |. .|||  |.      |.|.|
egd...............................................kgddartvaqfhftewPdkdvp.khtssllkfikevkadfGqythpliih

DEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
   |   .|   .. ... . .|   |||...   |   || .    ||| |.|  .|  
csagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavled

subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 2031-2284 7.8e-37 121.6 In-house 21-278 (287) alignment
Range on Protein: 2031-2284
Range on HMM: 21-278/287.0
SQSNIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAED
  |.     . || .  . .||| . ..|.. .|| .|  .  |.||||| |. .| . ..|| .| |.  |..||||.......  |...    . |  
edsesstatfkaaeelaavkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearl

E-FVYWPNKDEPINCESFKVTLMAEEHKclSNEekLIIQDFILEAT--QD-DYVLEVRHFQCPKWPNPDSPISK-TFELiSV----IKEEAANRDGPMIV
. . |||... |.    . |.|.  . |  . |    .. . |     ..   |  .  ...|.   . . ..   | | .|      .  |.  ||..|
kcykywPerevPmrvGGysvvlldydik..ePe..ygvralrlidletrearvvkqldllswPdkvlaPtavglirfvl.dvkqhielardasevGPlvv

HDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
||. |   .|.. |. .|...||.   ||| .|   .   | ..   . |...||. . .   
hddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvtyyk

subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 2034-2287 8.2e-34 111.8 In-house 8-268 (270) alignment
Range on Protein: 2034-2287
Range on HMM: 8-268/270.0
NIQQSDYSAALKqcNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQ-SNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE
. ..||  .| .  ... ||   |.|  ..|| ...|. .  | |||| |. |. . ....| .. ||  |.|.||||||..... .||. . ..   ..
etsesdlpeaar..gkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkk

-FVYWPNKDEP-INCESFKVTLMAEEHKclsNEEKLIIQDFILEaTQDDYVlEVRHFQCPKWPNPDSPISKT-----FELISVIKE-----EAANRDGPM
  .|||.. .  ...|  |.. .|....   .||  |..   || .. .   .. ||.  .||.   | ..       .|......     .  .. .|.
CerYWpaepkekvkledgkikvlalsee...keegyiltrlrle.ekgeer.rlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePl

IVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQ
.||.  |   .||. || . .. ||....||| .. . .   |. .    |||.||||...  ...|.
lvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaerra

subfamily_PTPN1_pd Subfamily PTPN1 2034-2281 2.8e-31 103.3 In-house 18-269 (290) alignment
Range on Protein: 2034-2281
Range on HMM: 18-269/290.0
NIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSlsgEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQN-MAEDEF
. .. . ..| .. ||..||   . | . ||. . .   . .|||||| .       ..|.|| || .|.. ||.|.|..... |||.    .      .
easdfptreaklpenrnlnryrdvspydhsrikler...adndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikca

VYWPNKDE--PINCE--SFKVTLMAEEHKclsneEKLIIQDFILEATQDDYVLEVRHFQCPKWPN---PDSPISKTFELISVIKEEAANRD-GPMIVHDE
 |||...|   . .|  ..||.|..||.|     .. ... . ||  . .   |. ||   .||.   |.|| .    |  | .  . ..| || ..|  
qywPqgeeekellledtklkvkliseerk.....syytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcs

HGGVTAGTFCALTTLMHQLEKENS---VDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
 |   .|||| . |.. ..||..    ||. .|   .  .| |.    .| .| |  || 
aGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile

subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 2034-2197 3.3e-16 54.0 In-house 19-180 (297) alignment
Range on Protein: 2034-2197
Range on HMM: 19-180/297.0
NIQQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSgEGTDYINASYIMGYYQS--NEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE
. .  ..|.| ..    |||   |. .. .|| .      ..||||| |..   .     .|..| ||  |..|||....... . .||.   |.   | 
eargesfssakrnsslrknryrdilatddtrvkllrvi.terdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedGrdk

-FVYWPNKDE-PINCESFKVTLMAEEHKclsNEEKLIIQDFILEATqdDYVLEVRHFQCPKWPNPDSP
 . |||. ..   .. .. |  ...      . ...|. .. |     .    ||| |   ||.   |
capywpsvvqerlkagdvvveflsstsd...efdrviltelqliyr..sesrvvrhvqflswpdhGvp

subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 2034-2286 1.1e-15 52.1 In-house 40-292 (305) alignment
Range on Protein: 2034-2286
Range on HMM: 40-292/305.0
NIQQSDYSAA-LKQCNREKNRTSSIIPVERSRVGISSLSgeGTDYINASYIMGY-YQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE
.. |  . |    . .  ||| . .   ..| | ..  |   .||| | |.       . || .| || .|| .|| |. ... . .||.    ..    
dmtqvafnanqsadiaitknryqdvpcqdqsavkldkps..psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklk

F-VYWPN-KDEPINCESFKVTLMAEEHKCLSNEEKliIQDFILEATQ-DDYVLEVRHFQCPKWPNPDSPISK--TFELISVIKEEaanrDGPMIVHDEHG
   |||  . |  .  |  |       | .  . .  ||  .|. |   |  . |||.|  .||.   |  |  ..||.| |.        |..||   |
caqywpaaqgeklelksgivvenvsgskpmerdae..iqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsairgs....kvpivvhcsag

GVTAGTFCALTTLMHQLE-KENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTR
   .||  |.  .. ..  . .   . .. | .   |     .  || |...|.|  .  .
igrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyflek

subfamily_CG42327_pd Subfamily CG42327 2035-2207 5.3e-17 56.5 In-house 18-186 (319) alignment
Range on Protein: 2035-2207
Range on HMM: 18-186/319.0
IQQSDysaALKQCNREKNRTSSIIPVERSRVGISSLS-GEGTDYINASYIMGYYQS-NEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA-EDE
| ..|   ..    ..|.|   ..|.  .||   . .  . . |..|||. || .. | .| .| .|  .  ||||..|. ... .| . | ..   .  
iarad...evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvc

FVYWPNKDEPINCESFKVTLMAEEHKclSNEEKLIIQDFILEATQDDYVLEVRHFQCpKWPNPDSPISKTfELISV
  |.| |.   | ...   |..  ..    ... .|  ..|   ...   |. |.   ||.. . | ...  ||..
aeylPtketldntslyGdilvtlkgr..evkdryaistlllkrvdkeesrelthywy.kwleaevPaeea.aliam

subfamily_PTPN14_pd Subfamily PTPN14 2036-2283 4.7e-32 106.2 In-house 37-296 (300) alignment
Range on Protein: 2036-2283
Range on HMM: 37-296/300.0
QQSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQ--SNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDG-QNMAEDEF
.....|.|  . | ||||.  ..| | .|| .|.   . |.||||| |       . ..|..| || .|..|||.|.|... ||.||. .  ..  |  |
edallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlteeeedgkeksf

VYWPNK---DEPINCESFKVTLMAEEhkclsNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPIS------KTFELISVIKEEA-----ANRDGP
 |.|..    . .. . ||||    |     . ...| . . |.        .| |.|   ||. . |           |. || ..        ... |
kyfPkleskkktvefgkfkvttkfse.....dsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnseveskeskPP

MIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLV
..||   |.  .|       |.. ||.....|. .| ...   |  . . . ||.|.|||..  .
vlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikyl

subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 2036-2140 1.1e-07 24.9 In-house 16-89 (169) alignment
Range on Protein: 2036-2140
Range on HMM: 16-89/169.0
QQSDYSAALkQCNREKNRTSSIIPVERSRVGISSL-SGEGTDYINAsyimgyyqsnefiitqhpllhtikdfwRMIWDHNAQLVVMIPDgqnmAEDEFVY
.  .. | |  ||  ||| .. .   . || .  .    |.|||||                           ||||. || ..|.. |    ..|   .
eynnfmael.tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgd....tddknnf

WPNKDE
||.|..
wpeked

subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 2036-2140 1.4e-07 24.5 In-house 15-88 (169) alignment
Range on Protein: 2036-2140
Range on HMM: 15-88/169.0
QQSDYSAALkQCNREKNRTSSIIPVERSRVGISSL-SGEGTDYINAsyimgyyqsnefiitqhpllhtikdfwRMIWDHNAQLVVMIPDgqnmAEDEFVY
.  .. | |  ||  ||| .. .   . || .  .    |.|||||                           ||||. || ..|.. |    ..|   .
eynnfmael.tcnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGd....tddknnf

WPNKDE
||.|..
wpeked

subfamily_PTPN13_pd Subfamily PTPN13 2037-2284 6.1e-37 122.4 In-house 25-270 (273) alignment
Range on Protein: 2037-2284
Range on HMM: 25-270/273.0
QSD-YSAALKQCNREKNRTSSIIPVERSRVgisSLSGEGTdYINASYIMGYYQSNEF--IITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAE-DEF
  |  . . |. |..|||   ..|....||    |..||. |||||.|    . .|.  |..| || .|.||||.|.|. .|....|.   ..  .    
pldtcevgkkkenkdknryrnvlPydetrv...klgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamvtlekekgkvkch

VYWPNKDE-PINCES-FKVTLMAeehkcLSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPiSKTFELISVIKEEAANR--DGPMIVHDEHGGV
 |||.. . ..  .. ..|.|.      . . . . .... .. ..   . || |..  |||. . | |.. ||. ...| .  .   ||..||   |  
rywPesknkklkvsnrlevellk.....vqkldgfvvralavkdsesgesrevahlnfvkwPdhgvP.ssaaellqfvaevrrlqtdagPivvhcsaGiG

TAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
 .||. .. ...  .|.....|| .. . .   | ||    .|| | ||.|| ...
rsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk

subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 2037-2281 1.7e-27 91.0 In-house 37-277 (439) alignment
Range on Protein: 2037-2281
Range on HMM: 37-277/439.0
QSDYSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIpdgQNMAeDEFVYW
. . | | .. .. |||  .. . . .|| .  . |   . |||| || |||. . .| || |  .| .||||.......  .||.    |.  . . ||
aciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekktvtivml...tnlv.esykyw

PNKDEPINCEsfkVTLMAEEHKCLSNeekLIIQDFILEATQDDY--VLEVRHFQCPKWPNPDSPI--SKTFELISVIKEEA-ANRDGPMIVHDEHGGVTA
| ..| .  .   ... ..    | |    .|. | .   .|       | .|.   ||. . |   |   ...  |.     .  ||..||   |  ..
psdaevcygd...iavrvdrnielpn...yvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrt

GTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
||  ||   . ||  || ||.  . |..   |  .  .. || |.|. .| 
Gtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavle

subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 2038-2282 7.8e-18 59.1 In-house 26-268 (281) alignment
Range on Protein: 2038-2282
Range on HMM: 26-268/281.0
SDYSAALKQ-CNREKNRTSSIIPVERSRVGISS--LSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDE-FV
||  ....|  | .||| . |  .. ||| .       . |||| | ||   .    .|.|| |   |  |||||||. |.  .||. .  .   ..   
sdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcae

YWPNKDEpiNCESFKVTLMAEEHKCLsnEEKLIIQDFILEatQDDYVLEVRHFQCPKWPNPDSPISKtfELISVIKEEAANRDGPMIVHDEHGGVTAGTF
|.| .     |  |    .. |   .  .. |.   . |    .     . |.   .||. . | |   |..  |  .   |  | ..|   |   .||.
yfprnah..cclqfdklsvsyedstv..nkslvttrlnls..yegetrlithwlwkewpdwqvpess..evmlkilrkirarstppvihcsagvgrsgtl

CALTTLMHQLEKENS-VDVYQVAKMINL-MRPGVFADIEQYQFLYKVILSL
 |.   .. .    .  |. |.   . .  |      ..|| ...||.| .
maveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf

0040439 (Phosphotyrosine protein) phosphatases II 2039-2282 1.3e-59 197.2 In-house 2-245 (249) alignment
Range on Protein: 2039-2282
Range on HMM: 2-245/249.0
DYSAALKQCNREKNRTSSIIPVERSRVGISSLSG-EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNM-AEDEFVYWP
.|| ||...|..||| ..|.| ..||| .|.|.| ...|||||||| |||....||.||.|| .|..|||||.|... . .||. . . .  |. . |||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

NkDEPINCESFKVTLMAEEHkclsnEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISKTFELISVIKE--EAANRDGPMIVHDEHGGVTAGT
. ....... |.|||. .|.     ......  . |. ..|. ...|.|.|...||  . |  .. ....|  ...  |.....||..||  .|   .||
l.ggsleygdftvtllsvev.....kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGt

FCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
|.|. ....|||||. ||.... |... .|||..   |||.|||...| |
fiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallel

subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 2039-2283 2.1e-37 123.6 In-house 35-277 (315) alignment
Range on Protein: 2039-2283
Range on HMM: 35-277/315.0
DYSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAE-DEFVYWP
   .| .. | .|||   |.|....|| .  .  .   |||||||| .. . . .| .| ||  ...|||||......  .||. . |.        |||
rqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywP

N-KDEPINCESFKVTLMAEEHKCLSNEEKLIIQdfileatQDDYVLEVRHFQCPKWPNPDSPIS--KTFELISVIKEEAANRDGPMIVHDEHGGVTAGTF
. | . ..  |.||.|.  |        ||...       . .    |  ||  .||.  ..      ..||  .| .  ... ...||   |   .| .
drkadsvefGsikvellsleadtdgvarklvtr.......kseesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvv

CALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLV
...   . |.....||||... |..   || .    |.| |.| ..|  .
isidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledl

0042113 (Phosphotyrosine protein) phosphatases II 2040-2282 1.9e-57 189.8 In-house 1-242 (245) alignment
Range on Protein: 2040-2282
Range on HMM: 1-242/245.0
YSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA-EDEFVYWPN
|| ||...|..||| |.|.| ...|| .|. .|. ..|||||||. ||.... ||.||.|| .|..|||||.|... . .||. .   .  .. . |||.
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

kDEPINCESFKVTLMAEEHkclsnEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSP--ISKTFELISVIKEEAA-NRDGPMIVHDEHGGVTAGTFC
 .|..... |.|||. |||     ......  . .. ..||...||.|...  ||  . |  ..  ..... ...  | ...||..||  .|   .|||.
.gesltygdftvtllseeh.....lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfi

ALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
|. ....|||||  |..... |... .|||..   .||.|||...| |
aaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallel

subfamily_PTPRK_pd Subfamily PTPRK 2040-2282 4.5e-54 178.4 In-house 35-276 (314) alignment
Range on Protein: 2040-2282
Range on HMM: 35-276/314.0
YSAALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA-EDEFVYWPN
. || |. ||||||.  |.. .|||| . .. |.  .|||||..| .| ....||.||.|| .|.|||||...|.|.  .||. . .. .      |||.
wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPe

KDEPinCESFKVTLMAEEHkclsnEEKLIIQDFILEA--TQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVIKEEAANRDGPMIVHDEHGGVTAGTF
. |    . .||.|.  |      ...|... | .|    . . . |||.||  .||. | | |.|  ..|.  .|.  ....|...||   |.  .|||
dtev..ygdikvelvetel.....laelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrtGtf

CALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
.|.....  .|.|. |||....| .   .. .    |||.|.| |||  
iaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvilea

0037934 (Phosphotyrosine protein) phosphatases II 2040-2282 3.1e-50 166.3 In-house 2-241 (243) alignment
Range on Protein: 2040-2282
Range on HMM: 2-241/243.0
YSAALKQCNREKNRTSSIIPVERSRVGIsslsgEGTDYINASYIMGYyqsNEFIITQHPLLHTIKD----FWRMIWDHNAQLVVMIPDGQ-NMAEDEFVY
.| ||...|..||| |.|.| ..||| .     ||.|||||..|...   . .|.||.|| .|..|    ||||.|... . .||. . . . .|. . |
fsiallpenlsknrysdilpydhsrvkl.....egsdyinanliyvt...prliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqy

WPnkDEPiNCESFKVTLMAEEHkclsnEEKLIIQDFILEATQ-DDYVLEVRHFQCPKWPN----P-DSPISKTFELISVIKEE-----AANRDGPMIVHD
||  .|  ... |.|||. |||      .. ..  . || .. ||....|.|...  ||     .  ... . .. .  . ||     |....||..|| 
wp..gev.tygdftvtllseeh.....lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHC

EHGGVTAGTFCALTTLMHQLekenSVDVYQVAKMINLMRPG-VFADIEQYQFLYKVILSL
 .|   .||..|. .....|    .||.... |..  .||| ..   .||.|||...| |
saGvgRtGtliaaylmllll....gvdleeavkllreqRpgkavqtpsqyrflyeallel

subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 2040-2158 3.8e-16 53.5 In-house 88-203 (244) alignment
Range on Protein: 2040-2158
Range on HMM: 88-203/244.0
YSAALKQCNREKNRTSSIIPVERSRVGISSLSgEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIpdGQNMAEDEfvYWPNKd
   |..  |  ||| .. .|.. .|| .|  |  |  |||||..    .. |.|.|||||  |  |||.|. .   ...|..  |    |||  |||.  
mkdafnpnnswknregaglpfdfnrvplskgs.mgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvl..gsveeede..ywpds.

EPINC--ESFKVTLMA-EEHKC
||..   |   |||   .| | 
eplewyeeditvtltdrdefkn

subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 2041-2281 4.8e-45 148.8 In-house 42-277 (315) alignment
Range on Protein: 2041-2281
Range on HMM: 42-277/315.0
SAALKQCNREKNRTSSIIPVERSRVGISSLS-GEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFV-YWPNK
  | |  |..|||   ||. ..||| .  |   ...||.||..| || . . .| .| |.  ..|||||......   .||. .  .  .     |||.|
dvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk

dePINCESFKVTLMAEEHKclsneEKLIIQDFilEATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVIKEEAANRDGPMIVHDEHGGVTAGTFCAL
   .    . ||.. ||..     ... .. .    . .| . ||  ..   ||. . | . .   .||  .|    |  |...|| . |   .|||..|
..kviyGkitvtrkseevn.....teytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitl

TTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
 ....|.| || .|||.. . .  .| .. . .|||||.|...| 
davldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle

0049772 (Phosphotyrosine protein) phosphatases II 2041-2287 7.5e-34 113.2 In-house 39-284 (314) alignment
Range on Protein: 2041-2287
Range on HMM: 39-284/314.0
SAALKQCNREKNRTSSIIPVErSRVGISSLSGEGTDYINASYIMGYyqsNEFIITQHPLLHTIKDF----------WRMI--WDHNAQLVVM--------
 .| . .||.|||.  |.|.. .||....|...|.|||||||. |.   . ||.||.|| .|. ||          |||.  .|.|   .||        
lvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevlad

---------------IPDGQNmaedefvywpNKDEPINCESFKvtlmaeehkclsneekliiqdfilEAT--QDDYVLEVRHFQCPKWPNPDSPISKTF-
               |.||..          |   . . | .|                        | .  ....  .. .. .  .| .. |... | 
elsrLdaAlgKtpllildgng..........neptaadlellk........................eelydpelferlgikylripvpDgsaplledfd

ELISVIKEEaaNRDGPMIVHDEHGGVTAGTFCALTTLMHQLekenSVDVYQVAKMINLMRP-----GVFADIEQYQFLYKVILSLVSTRQ
|.. .|.|   ...|| .||  .|   .|||...  ||..|     |.. .. ... |.||     | .   |||.| ....| .... .
eflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkflk

subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 2041-2286 5.7e-15 49.8 In-house 40-290 (305) alignment
Range on Protein: 2041-2286
Range on HMM: 40-290/305.0
SAALKQ-CNREKNRTSSIIPVERSRVGISSlsGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQ-NMAEDEFVYWPNK
  |.|.  ...|||   .  ... || . .      .|| | |.    ... || || || .|  ||| | .... . . |. . .   |.  . |.. |
mkafkeaqeagknrykdvgcldnnrvkleg..pwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfask

DEPI---NCESFKVTLMAEEHKCLSNEE----KLIIQDFILEATQdDYVLEVRHFQCPKWPNPDSPISKTfELISVIkEEAANRDGPMIVHDEHGGVTAG
|...   . .  |...  |  . |. ..    |.    ...| .    .. | |.    ||.   | . .  .. .. |.|    ||..||   |   .|
dkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpg.ekarkvthyhwidwpdrgvpaadl.ailell.ekarpskgpivvhcsagigrtg

TFCALTTLMHQLEKENSVD-VYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTR
.   |  ...||   . ..   .. . |   |       .|| |...|||  .  .
svvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfrkk

subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 2042-2280 3.8e-23 76.9 In-house 2-238 (239) alignment
Range on Protein: 2042-2280
Range on HMM: 2-238/239.0
AALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYINASYIMGYYQSN-EFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQN-MAEDEFVYWPNK
|| |. |. ||| . |.  ..||| .  || .  .|||||||.  |  |   .| ||  .  .  |||||.|.    ..||.    .   .  . |||. 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

DEpINCeSFKVTLMAEEHKClsneeKLIIQDFILEA---TQDDYVLEvrhFQCPKWPNPDSPISKT--FELISVIKEEAANRDGPMIVHDEHGGVTAGTF
     |  ..|||   |  .       ||. |..     |.. || .   ..   ||.   |   |  . |   | ...     | ..|   |   .|.|
ts.kyc.nlrvtlrktevfa.....dyiirtfvmsqvgqteeryvyq...yhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaf

CALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
  . ....| .|...||...  | |   || .    ||| |..  .|
lvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 2042-2280 5e-23 76.5 In-house 1-237 (239) alignment
Range on Protein: 2042-2280
Range on HMM: 1-237/239.0
AALKQCNREKNRTSSIIPVERSRVGISSLSGEG-TDYINASYIMGYYQSN-EFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQN-MAEDEFVYWPNK
|| |. |. ||| . |.  ..||| .  || .  .|||||||.  |  |   .| ||  .  .  |||||.|.    ..||.    .   .  . |||. 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

DEpINCeSFKVTLMAEEHKClsneeKLIIQDFILEA---TQDDYVLEvrhFQCPKWPNPDSPISKT--FELISVIKEEAANRDGPMIVHDEHGGVTAGTF
     |  ..|||   |  .       ||. |..     |.. || .   ..   ||.   |   |  . |   | ...     | ..|   |   .|.|
ts.kyc.nlrvtlrktevfa.....dyiirtfvmsqvgqteeryvyq...yhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaf

CALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
  . ....| .|...||...  | |   || .    ||| |..  .|
lvidamlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavl

subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 2043-2287 1.4e-48 160.2 In-house 4-246 (250) alignment
Range on Protein: 2043-2287
Range on HMM: 4-246/250.0
ALKQCNREKNRTSSIIPVERSRVGISSLS-GEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNkDEP
| |  |.|||| . ||... ||| . . .  . .||||||.. || ... ||.||.|| .||.|||||....... .||. . ... .    |||  ...
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPv.eka

INCESFKVTLMAEEHKCLSNEEKLIIQdfileATQDDYVLEVRHFQCPKWPNPDSPISKT--FELISVIKEEAAN-RDGPMIVHDEHGGVTAGTFCALTT
 .  . .|.|. .|..      ||..       ..      ||...   ||.   |   |  .||.. .. .  .  ..|.||.   |   .|.|.|. .
ekyGdvtvsllskeefadytkrklkls.....kakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaida

LMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTRQ
....|.||. |||..| |..   ||..    ||| |.|..||  . . .
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsve

subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 2043-2284 9.7e-34 111.3 In-house 38-277 (515) alignment
Range on Protein: 2043-2284
Range on HMM: 38-277/515.0
ALKQCNREKNRTSSIIPVERSRVGISSLSGE-GTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAED-EFVYWPNK-D
| .. | .|||   |.| ...|| .  .  .   ||.||||| ..   . .| .| |.  ...||||.....|   ..|. . ..        |||.|  
aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpg

EPINCESFKVTLMAeehkcLSNEEKLIIQDFILeaTQDDYVLEVRHFQCPKWPNPDSPISkTFELISVIK---EEAANRDGPMIVHDEHGGVTAGTFCAL
. ..  |.|| |..     |.     |.. . .  ...| .  |  |.  .||.  .|   |  |. .||    .  .   |.|.|   |   .| ....
dsvkfGsikvelvs.....leactggikrkltv..lkgddsrtvtqfhfteWPdkGvpkh.tssllklikevkadhgqythpliihcsaGvGrtGvvisi

TTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSLVS
   . . .. ..|||... . |   || .    ||| |.| ..|  . 
dsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledll

subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 2045-2281 6.8e-15 49.8 In-house 32-268 (285) alignment
Range on Protein: 2045-2281
Range on HMM: 32-268/285.0
KQCNREKNRTSSIIPVERSRVGissLSGEGTDYINASYI-MGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDG-QNMAEDEFVYWPNK-DEP
 ..| . || . .  .| .||    |     ||| ||.. |   . . .| || ||  |. |||.||.. .   |.|.    .   |   .|.|.|  | 
yeanpdlnryadvrcieetrvv...lknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

INCESFKVTLMAEEHKCLSNeekLIIQDFILEATQDD--YVLEVRHFQCPKWPNPDSPIS--KTFELISVIKEeAANRDGPMIVHDEHGGVTAGTFCALT
..   ...||   . ....     |.. . .  |.|     | . | | | ||.  .|       ||   .|.    .. |. ||   |   . ||  . 
vkfgkyeitlteckeeaiag...tilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkk.vnpkekpicvhcsagvgrtatfvgid

TLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILS
    .. ..  ... .. . .  ||        |. ||| |.. 
yatirimenpniemldivremramrfqavqshmqflflyvvlme

subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 2046-2278 2.4e-16 54.3 In-house 48-273 (301) alignment
Range on Protein: 2046-2278
Range on HMM: 48-273/301.0
QCNREKNRTSSIiPVERSrVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAED-EFVYWPN-KDEPIN
  ...|.|  .. | . |   .  ..      | | .|    ... ||.|| ||  | .||| |.  .. . .||.    .  |.    | |    | ..
ylpkdkhryptv.PckPs.tavevivdGkrvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekld

CESFKVTLMAEEHKClsnEEKLIIQDFILE-ATQDDYVLEVRHFQCPKWPNPDSPIS--KTFELISVIKEEaanrDGPMIVHDEHGGVTAGTFCALTTLM
 . ||...  .|.     ..|.. . . .| .|..     | |.|  .|.. . | |  ..|.|. ..|.     . |..||   |   . .| .   | 
igrfkikiknkelil...nkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkks....ekPivvhcsaGiGrsvafigteyla

HQLEKENSVDVYQVAKMinlMRPGVFADIEQYQFLYKV
...| .. ... .  |    .|   .  . . . || .
reveadptieltealkh...lrehrwngvqtnsqlywm

subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 2047-2282 6.6e-16 52.8 In-house 55-282 (290) alignment
Range on Protein: 2047-2282
Range on HMM: 55-282/290.0
CNREKNRTSSIIPVERSRVGISslSGEGTDYINASYIMGYyqSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIP----DGQNMAEDefvYWPNKDEPI
 . .|||   ..  ...|| ..   |   ||. | |. |      ||.|| .|  |. |.|||. ....  .||.     ||.   |.   |.|.|.  .
tefkknrykdvvcndktrvilk..dGydGdyvhanyvkGl..kamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceq...yypekeGev

-NCESFKVTLMAEEHKclsnEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDSPISkTFELISVIKeEAANRDGPMIVHDEHGGVTAGTFCALTTLMH
    .. |.   |..|    ....| . . .   ..     ..|..   ||.   . | |. |. ...    .  ||..||   |   .||| |. . . 
ltfGeitvlcseeddk....daniikktlsvrdkdsGkehklkhlkikswpdksvals.tlallrtlr.ilrkasGpvvvhcsaGiGrtGtfvaievglq

QLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
 | .  ..|. .. . .   | .      ||  | ...| |
illdGkeldlldlvralrnsrlnsvqvdiqylalveilldl

subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 2047-2281 2.3e-11 38.2 In-house 42-269 (288) alignment
Range on Protein: 2047-2281
Range on HMM: 42-269/288.0
CNREKNRTSSIIPVERSRVGISslsGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA-EDEFVYWPNKD-EPINC
 |  ..|   .   . .|| .|    .   ||.|  .      . .| .| ||  ||. .|.|. . . . .||. .  .   |   .|.| |  | .  
anptrdryenlprcditrvkls...ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGekari

ESFkVTLMAEEHkclSNEEKLIIQDFILEATQDDYVLEVRHFQCPKWPNPDspISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFcALTtLMhQLE
  .  | . ...   .. .||.    .    . .    |..    .|..    . . .     . |   . . |..|| ..|   .||. .|. |.  ||
grl.ctvvkkkr...adidklvkvsllriskegeekvivkilhlleWdddg..vPenylsplrllevlkslqkPivvhssaGvGrtgtl.ili.li.ale

KENSVDVYQVAKMINLMRPGVFADIE---QYQFLYKVILS
   ..|   . .... .|   |  |.   || ......| 
slrlddflgirsllaklreerfkaiqtemqylyvhrcvle

subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 2047-2123 2.1e-06 21.5 In-house 33-109 (332) alignment
Range on Protein: 2047-2123
Range on HMM: 33-109/332.0
CNREKNRTSSIIPVERSRVGISSLSGEgTDYINASYIMGYYQSNEFIITQHPLL-HTIKDFWRMIWDHNAQLVVMIPD
 | . ||   .  ...||| ..   |.  |. |||.. || . . .|..| |.  ||   ||||. ...  ..... |
nnmdmnriphlycfdhsrvelapqdgk.ddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd

Y_phosphatase Protein-tyrosine phosphatase 2048-2280 2.6e-58 192.6 Pfam-A 1-234 (235) alignment
Range on Protein: 2048-2280
Range on HMM: 1-234/235.0
NREKNRTSSIIPVERSRVGIsSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNM-AEDEFVYWP-NKDEPINCE
|..||| ..|.| ...|| . . |.. .|||||.|..|| ....||.||.|| .||.|||||.|... ...||. . ...  |    ||| ...|. ...
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

SFKVTLMaeeHKCLSNEEKLIIQDFILEATQDD-YVLEVRHFQCPKWPNPDSP--ISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQ
..||.|.   .|  ..|.. ..... |. ....    ||..... .||. . |   .. ..||  .... ....||..||  .|   .|||.|| .|..|
dikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

LEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
||.|..|||.|. |..   |||.. ..|||.||||.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail

Y_phosphatase Protein-tyrosine phosphatase 2048-2280 2.6e-58 192.6 In-house 1-234 (235) alignment
Range on Protein: 2048-2280
Range on HMM: 1-234/235.0
NREKNRTSSIIPVERSRVGIsSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNM-AEDEFVYWP-NKDEPINCE
|..||| ..|.| ...|| . . |.. .|||||.|..|| ....||.||.|| .||.|||||.|... ...||. . ...  |    ||| ...|. ...
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

SFKVTLMaeeHKCLSNEEKLIIQDFILEATQDD-YVLEVRHFQCPKWPNPDSP--ISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQ
..||.|.   .|  ..|.. ..... |. ....    ||..... .||. . |   .. ..||  .... ....||..||  .|   .|||.|| .|..|
dikvelk...ekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleq

LEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
||.|..|||.|. |..   |||.. ..|||.||||.||
leaeeevdvlqivkelRkqRpgmvqsleqYiflykail

0041856 (Phosphotyrosine protein) phosphatases II 2048-2282 3.5e-37 123.1 In-house 1-170 (182) alignment
Range on Protein: 2048-2282
Range on HMM: 1-170/182.0
NREKNRTSSIIPVERSRvgisslsgeGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPdgqnmaedEFVYWPnkdepincesf
|..|||.| |.|...||         . |||||....|.. ...||.||.|||.|. ||.||..... ...|..         |. |||           
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt........eelywp...........

kvtlmaeehkclsneekliiqdfileATQDDYVLEVRHFQCPKWPNPDspISKTFELISVIKEeaanRDGPMIVHDEHGGVTAGTFCALTTLMHQleken
                              ...........| .. ||  .......|  ..|    ..|| .||  .|   .||..|.  ....     
..........................ellerlgiqylylpwpDhgvpd..ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....

SVDVYQVAKMINLMRPGVFADIEQYQFLYKVILSL
.|..... |... .|||..   .||.||. ..| |
gvsleeavklvrsrRpgmvitpnqyfflqlallel

subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 2048-2280 9.1e-25 82.2 In-house 3-236 (237) alignment
Range on Protein: 2048-2280
Range on HMM: 3-236/237.0
NREKNRTSSIIPVERSRVGISSlSGEGTDYINASYIMGYYQS-NEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAED-EFVYWPNKDEPINCE
|. ||| ..|.  . ||| .   .| |.|||||.|. |.  . ...| .| ||  . .|||.|.|. .  ..||.    .  |     |||. |.|    
nkiknrygnivaydhsrvvlkg.agsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaayg

SFKVTLMAEEHKCLSNEEKLIIQDfilEATQDdYVLEVRHFQCPKWPNPDSPISKTFELI---SVIKEEAA-NRDGPMIVHDEHGGVTAGTFCALTTLMH
 . |.|  .|. .      |...    . |.   |  .  .|   ||.   |   .  |     .|..    .. || |.|   |   .| |  . ....
vltvslkkkeefsdytvrslllsk...rltlk.evrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlr

QLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
| .... ||.|.  . |.  || .    .|| |....||
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtil

subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 2048-2280 1.8e-12 41.5 In-house 47-276 (303) alignment
Range on Protein: 2048-2280
Range on HMM: 47-276/303.0
NREKNRTSSIIPVERSRVGISSLSgegtdYINASYIMgYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMI-PDG-QNMAEDEFVYWPNKDePINCE
| .|||   .| .. |.| .|  |     || |||.     |.  |.|| || ||  |||.|| . . . |...  |.  .    ..|.  |.|  .. |
nmdknrfvdvicldhskvklsdss.....yihasyle.ldsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqd.flkfe

SFKVTlmAEEHKCLSNEEKLIIQDFILEATQDDYVLEVRHFQcpKWPNPDSPIS-------KTFELISVIKEEAAnrDGPMIVHDEHGGVTAGTFCALTT
   .     | | .   .   ..   .   .    | | |..  .||  . |         . ..| ||..  .     | .     |   ||||. . |
ersir..vgefkrvelgdgwvlkvlsvsngdyksflhvhhyk..awphnsipsdgspkfvkqiwqlqsvlrkysd..stptvymslsgcgragtfalfet

LMHQLEKE-NSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
    | .| .|.|. .. ...   |     .. |. ..| .. 
ahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytlla

subfamily_eak_pd Subfamily eak 2048-2210 6.4e-08 26.4 In-house 52-209 (332) alignment
Range on Protein: 2048-2210
Range on HMM: 52-209/332.0
NREKNrTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDG-QNMAEDEFVYWPNKDEpincES
. ..|    |.| .|  | ..|   .   ||||| .      ...|.|  .    .  ||.|. . ..  .|.. .  ..  |    |.|.|      | 
avnrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr....ee

FKVTLMAEEHKCLSNEEKLIIQDFILEATQDdyVLEVRHFQCPKWPNPDSPISKTFE-LISVIKE
.|   .  | |   ....|  . ..|.   .    .| |..   | . . |. . |  |  |.||
lkfGildverkefvkrniletrllelskGne..thrvlhykvfGwtettlpkyedflalrkvmke

subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 2050-2138 9e-07 22.5 In-house 50-156 (349) alignment
Range on Protein: 2050-2138
Range on HMM: 50-156/349.0
EKNRTSSIIPVERSRVGI---------------SSLSGEGTDYINASYIMG--YYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMA-EDE
 ||| . |.| | ||| .                | ||   ||||| |.    .   . .| || ||  |..||...|   . .||. . | .. . |  
aknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekc

FVYWPNK
 .|| . 
diywqel

subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 2054-2132 6.3e-10 33.1 In-house 52-128 (347) alignment
Range on Protein: 2054-2132
Range on HMM: 52-128/347.0
TSSIIPVERSRVGissLSGEGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDG-QNMAEDEF
|  ..  |.|. .    . .   |||||.|     |.|.|.||.|| .|..|||.|.   .   || | .  .. | .||
trvvlspekskns...raddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikdeaieef

0044763 (Phosphotyrosine protein) phosphatases II 2060-2283 3e-22 74.5 In-house 2-171 (178) alignment
Range on Protein: 2060-2283
Range on HMM: 2-171/178.0
VERSRVGISSLSG-EGTDYINASYIMGYyqsneFIITQHPLlhtiKDFWRMIWDHNAQLVVMIPDGQNMA-EDEFVYWPNKDEpincesfkvtlmaeehk
..|.|| .|.|.| |..||||||.|...     ......|      |......... ...|.. . . .  .... ||| . .                 
ldrtrvllsnleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.................

clsneekliiqdfileatqddyvLEVRHFQCPKWPNPDsPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQlekenSVDVYQVAKM
                       ....|. .| ...||  .. ..|..  |.|  ....|| .||  .|   .||..|.  ....     ....... ..
.......................iqylhipipDhgvpd.llehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl.....glsleeaiel

INLMRPgVFADIEQYQFLYKVILSLV
.  .|| ..   .|...||.. | | 
vrerRp.ivpnpgqlrqLyefelrll

subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 2071-2176 7.7e-11 36.4 In-house 11-111 (130) alignment
Range on Protein: 2071-2176
Range on HMM: 11-111/130.0
SgeGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIpdGQNMAEDEfvYWPNkDEPIN--CESFKVTLMAEEHKCLSNEEKLIIQ
   | .|||||..    ...|.. |||||  |  |||.|. .    ..|..  |    |||  |||.  ||..   |   |||   .     . ..| |.
q..gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvl..gsveeede..ywpd.sePlewyeediivtltdrdefknikasnleie

DFILEATQ
. . |. |
sdlneshq

0046846 (Phosphotyrosine protein) phosphatases II 2072-2281 1.5e-23 78.9 In-house 9-171 (176) alignment
Range on Protein: 2072-2281
Range on HMM: 9-171/176.0
GEGTDYINASYIMGYYqsneFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAEDEFVYWPNKDEPINCesfkvtlmaeehkclsneekliiqdfi
... |||||..|.|..    .|.||.|| .|. ||..|..... ..||.. . . ..   . ....  |  ..                           
dldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi...........................

leatqddyvlevrHFQCPKWPNPDSPISKTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTtlmhQLEKENSVDVYQVAKMINLMRP-GVFADIE
             ....  ||  . | .. .. .  . .|| ...|| .||  .|   .||..|.      ||.|. ..|... ...  .|| |..   |
.............qylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavqtpe

QYQFLYKVILS
||.|||...| 
Qyrflyefell

0043147 (Phosphotyrosine protein) phosphatases II 2073-2276 6e-26 86.6 In-house 3-154 (172) alignment
Range on Protein: 2073-2276
Range on HMM: 3-154/172.0
EGTDYINASYIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGqnmaedefvywpnkdepincesfkvtlmaeehkclsneekliiqdfil
||.|||||||. .||  ..||.|| || .|. |||||..... ...|.. .                                                 
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel................................................

EATQDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEE--AANRDGPMIVHDEHGGVTAGTFCALTTLMhqlekeNSVDVYQVAKMINLMRPGVFADIE
. . .... .. ....  ||  . |... .. .  . .|  | ...||..||  .|   .||..|.  ..       ....... ...  .|||..   .
lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnps

QYQFLY
||.|||
qyrfly

0036282 (Phosphotyrosine protein) phosphatases II 2074-2277 2.5e-30 100.8 In-house 1-164 (174) alignment
Range on Protein: 2074-2277
Range on HMM: 1-164/174.0
GTDYINASYIMGYYQSNEFIITQHPLLhtikdFWRMIWDHNAQLVVMIPDGQNMA-EDEFVYWPNkdepincesfkvtlmaeehkclsneekliiqdfil
|.||||||.. ..| ....|..|.||      ||.|..... . |||  . . .  .  . |||                                    
gsdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe...................................

eaTQDDYVLEVRHFQCPKWPNPDSP-ISKTFELISVIKEEAAN-RDGPMIVHDEHGGVTAGTFCALTTLMHQLEkENSVDVYQVAKMINLMRPGVFADIE
  ...|.. .. ....  ||    | .|. .|... ..|  .. ..||..||  .|   .||..|.  ....|. |. ||.... ... |.|||..   .
..lredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtps

QYQFLYK
||.|||.
Qyrflyy

0051429 (Phosphotyrosine protein) phosphatases II 2074-2286 8.7e-28 93.1 In-house 3-228 (272) alignment
Range on Protein: 2074-2286
Range on HMM: 3-228/272.0
GTDYINASYIMGYYQ---SNEFIITQHPLLHTIKDFWRMiWDHNAQLVVMIPDGQNMAEDE-FVYWP-----------NKDEPINCESFKVTLMAEEHKC
 ..||||... ||..    . .. ...|| .|..||||. ....   .|.. .   .. .  . |||           . ...|.   . |||. ||.. 
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

LsneekLIIQDFILEAT-QDDYVLEVRHFQCPKWPNPDSPISKTFELISVIKEeaanrDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVD-------
       |.  ..|. . . . ..||.|...  ||    | .   ||.... .     .||..||  .|    ||..||  |......|  ||       
d.....yilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-VYQVAKMINLMRPGVFADIEQYQFLYKVILSLVSTR
 .... ...  .|||.. . |||.|||...| |. . 
yleeaveelraqrpgavqteeqylflyeallellrsl

0051082 (Phosphotyrosine protein) phosphatases II 2074-2279 2.6e-21 71.2 In-house 2-149 (151) alignment
Range on Protein: 2074-2279
Range on HMM: 2-149/151.0
GTDYINASYIMGYyqsneFIITQHPllhtIKDFWRMIWDHNAQLVVMIPDGQNMAeDEFVYWPNKDepincesfkvtlmaeehkclsneekliiqdfile
 .||||.||. |.     ......|      ||........ . .|.. . . ..  .  |.|. .                                  
lsdyinfsyvtgg.....lyrsggp....ladflellkelgiktivnlrseeerg.ycpeylpelg..................................

atqddyvLEVRHFQCPKWPNPDSPISkTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQlekensVDVYQVAKMINLMRPGVFADIEQYQ
       .||.|.... ||.|. |.| . ........ .....||..||  .|    ||..||  ....      |..... ... |.||||.   .|..
.......ievlhipildwpdpglpls.fdavleflellldkkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqfl

FLYKVI
|.....
fqlfal

subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 2075-2283 2.8e-10 34.8 In-house 46-259 (290) alignment
Range on Protein: 2075-2283
Range on HMM: 46-259/290.0
TDYINASYIMgYYQSNEFIITQHPLLHT-------IKDFWRMIWDHNAQLVVMIPDGQNMAED--EF---VYWPNK-DEPINCESFKVTLmaeehkcLSN
 ||| |...  . .  ..|.|| |. ..       |..|| |. . ... |||. . ..  ..  .|    | |.. .| .. . ..|          | 
ddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkC.......ksk

EE--KLIIQDFILEaTQDDYVLEVRHFQCPKWPNPDSPiSKTFELISVIKEEAaNRDGPMIVHDEHGGVTAGTFCALtTLMHQL--EKENSVDVYQVAKM
|.   ...   ...  .|.  . | | .   | .   .  .|  |.|.|.    ... |.|||.  |     .. |.  |  |.  |...|| . .| |.
ekeddvetRelvvk.fddeeeftvtHsllkgWnklnvq.edtktllsliqkvk.asktpvivHcvdGiSrsAalaai.ilgyQkiaetsgsvkledvlka

INLMRPGVFADIEQYQFLYKVILSLV
.  .|  .. . ... |   .|. |.
lrkqralaitsalelafvdagivlla

0049260 (Phosphotyrosine protein) phosphatases II 2082-2277 1.4e-21 72.2 In-house 1-144 (152) alignment
Range on Protein: 2082-2277
Range on HMM: 1-144/152.0
YIMGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAED-EFVYWpnkdepincesfkvtlmaeehkclsneekliiqdfileatqddyv
.| ||....|||.||.|. .|..|||||....... .||. . . .... .  |.                                             
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................

lEVRHFQCPKWPNPDSPISKTFeLISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMhqlekeNSVDVYQVAKMINLMRPGVFADIEQYQFLYK
 .. |...|  . ||...   | |. .|.. | ...|| .||  .|   .||..|.  ..      . |..... ...  .|||..   .|..|||.
.qylhlpwpDhgvpdlsqlllf.lllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2084-2192 9.8e-10 32.3 In-house 230-329 (440) alignment
Range on Protein: 2084-2192
Range on HMM: 230-329/440.0
MGYYQSNEFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPdgQNMAEDEFVYWPnkdepINCESFKVTLMAEEHKCLSNEEKLIIQdfILEATQDDYVLEV
 || . | || || ||  |. ||||.. |..   ..|.   |       .|||     .|  |     ..  ||   | ... ..   ||    . | |.
egyskknafiatqmpldstvldfwrlvhdyristiimln..qlndktcsiywp.....vntrsvtfgpftvghkgsenmnrvkvr..tlelkykeevhei

RHFQCPKWP
| |.   ||
rqfevqtwp

subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 2084-2286 1.3e-07 24.6 In-house 109-312 (346) alignment
Range on Protein: 2084-2286
Range on HMM: 109-312/346.0
MGYYQSNEFIITQHPLLH---TIKDFWRMIWDHNAQLV-VMIPDGQNMAEDEFVYwpnKDEPINCESFKVTLMAEEHKCLSNEEKLIIQDFILEATQDDY
. .   ...|..| | ..    ..||| ||.. . .|| .|.|| .       ..   .||    .     .. . .  .| . |    . . |   |  
vifqfehklivaqlpqmenesfvedfwymiyqeqihlvylmvpddklkntttslf...ndenggyqytgkmfinnrradvsgdpkeytievlpegnsdsv

VLEVRHFQCpkWPNPDSPiSKTFELISVIK---EEAANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLY
. .| |     |   . |  ||. .| .|.    |   ..  . |    |   | .|      ..||.     ..... | |   |||    . ||  .|
icqvhhhap..wkhlqqp.pktlpiikmihqflsekqvqnagvcvvslfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiy

KVILSLVSTR
 ...  .. .
aivfdyiark

subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 2091-2278 1.4e-21 71.6 In-house 6-199 (199) alignment
Range on Protein: 2091-2278
Range on HMM: 6-199/199.0
EFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAE-DEFVYWPNKDEpincESFKVTLMAEEHKCLSNEEKLIIQDFILE--ATQDDYVLEVRHFQ
 .| ||||| .|. |||.|.|.  .  .||. | |.  | |  .|||  .      . | . ..   |... .    |  .||   .|      |. |.|
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttes....gtgkygslsvttktittkpdytitaliltnnttappstreishyq

CPKWPNPDSPISKTFELIS-----VIKEEAANRDGPMIVHDEHGGVTAGTFCALTTL--MHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKV
   | .  .|    |  .      | |    ..| |.|||   |   .| | ||      |.  |   ||...||| .   | |. . ...|.|.|.|
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv

subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 2091-2278 1.4e-21 71.6 In-house 5-198 (198) alignment
Range on Protein: 2091-2278
Range on HMM: 5-198/198.0
EFIITQHPLLHTIKDFWRMIWDHNAQLVVMIPDGQNMAE-DEFVYWPNKDEpincESFKVTLMAEEHKCLSNEEKLIIQDFILE--ATQDDYVLEVRHFQ
 .| ||||| .|. |||.|.|.  .  .||. | |.  | |  .|||  .      . | . ..   |... .    |  .||   .|      |. |.|
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttes....gtgkygslsvttktittkpdytitaliltnnttappstreishyq

CPKWPNPDSPISKTFELIS-----VIKEEAANRDGPMIVHDEHGGVTAGTFCALTTL--MHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKV
   | .  .|    |  .      | |    ..| |.|||   |   .| | ||      |.  |   ||...||| .   | |. . ...|.|.|.|
ftswkekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv

0048179 (Phosphotyrosine protein) phosphatases II 2169-2277 3.2e-08 28.9 In-house 35-139 (144) alignment
Range on Protein: 2169-2277
Range on HMM: 35-139/144.0
DFILEATQDDYVLEVRHFQCPKWPNPDSPIS-KTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTtLMHqlekENSVDVYQVAKMINLMRPGVFA
... |  ....  |. ....  ||. . | . . .. .  . ||| ...||..||  .|   .||..|.  ||.    .. ...... ...  .|||.. 
nlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaay.lmk....klglsleealalvrsrrpgavp

DIEQYQFLYK
  .|..||..
npgqlrfLle

0048076 (Phosphotyrosine protein) phosphatases II 2173-2281 6.3e-10 34.4 In-house 37-141 (145) alignment
Range on Protein: 2173-2281
Range on HMM: 37-141/145.0
EATQDDYVLEVRHFQCPKWPNPDSPIS-KTFELISVIKEEAANRDGPMIVHDEHGGVTAGTFCALTTLMHqlekeNSVDVYQVAKMINLMRPGVFADIEQ
  ...... .. ....  ||  . | . .... .  . ||| ...||..||  .|   .||..|.  ...     ..|..... ...  .|||..   .|
tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmll.....lgvsleealelvrsqrpgavpnpgq

YQFLYKVILS
..|||...| 
lrflyefele

PTPc_DSPc_SM00012 2183-2280 2.5e-20 68.0 In-house 2-104 (105) alignment
Range on Protein: 2183-2280
Range on HMM: 2-104/105.0
VRHFQCPKWPNPDSPI--SKTFELISVIKEEAANRD--GPMIVHDEHGGVTAGTFCALTTLMHQLEKE-NSVDVYQVAKMINLMRPGVFADIEQYQFLYK
|.|.....||.   |   .. .||.  .|..  ...  .|..||. .|   .|||.|| .|..||||| ..||..|. |..  .|||..   |||.|||.
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

VIL
..|
all

subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 2210-2279 1.4e-06 21.9 In-house 364-434 (440) alignment
Range on Protein: 2210-2279
Range on HMM: 364-434/440.0
EEAANRDGP-MIVHDEHGGVTAGTFCALTTLMHQLEKENSVDVYQVAKMINLMRPGVFADIEQYQFLYKVI
|..   ||| ..||   |   .| ||..   . ||... ..||.|  ... | ||     . .| . ||..
eqsrpgdgppilvhclsgieesgvfctvmncleqlnndgaidvfqnlrllrlsrpnfvptltdyllcykll

subfamily_CG42327_pd Subfamily CG42327 2213-2280 1.5e-07 25.4 In-house 244-312 (319) alignment
Range on Protein: 2213-2280
Range on HMM: 244-312/319.0
ANRDGPMIVHDEHGGVTAGTFCALTTLMHQLEKE-NSVDVYQVAKMINLMRPGVFADIEQYQFLYKVIL
 .. ||..||   |   .|.  |    ...||.  .|||. |.   .   |     ..|||.|.|||. 
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvls