Gene PTPRK in Homo sapiens

Synonym: R-PTP-kappa, RP3-480J14.1, PTPRK

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRK
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP101_AA protein Get Run
HsapP101_AA_894-1174 phosphatase_domain Get Run
HsapP101_AA_1186-1468 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
MAM MAM domain 36-193 3e-42 132.5 Pfam-A 1-159 (160) alignment 
Range on Protein: 36-193
Range on HMM: 1-159/160.0
CTFDDGpgACDYHQDLYDDFEWVHVSAQEP-HYLPPEMPQ------GSYMIVDSSDHDPGEKARLQLPTMKENDTHCIDFSYLLYSQKGlnpGTLNILVR
|.|...  .|...||  ||..| .||...| ..  |....      |.||.|..|.. .||.||| .|........|..|.| .....    ||||..||
CdFeee..lCgwsqdetddldWtrvsgstptektgpssdhtlgkesghymyvetssgaegesarllspllpasssaClrFyyhmsgsev...gtLnvyvr

VNKGPLANPIWNVTGFTGRDWLRAELAVSTFwPNEYQVIFEAEVSGGRSGYIAIDDIQVLSYPCD
 .|..  ...|...|  |..|..||...|.. ....||.|||... |..|.||.|||.. ...| 
eekegeetllweisgnqgssWqeaevtlsai.tkkfqvvfeavrgkgsegdialDdislsegeCs
Ig_2 Immunoglobulin domain 201-288 1.8e-09 29.5 Pfam-A 6-80 (80) alignment 
Range on Protein: 201-288
Range on HMM: 6-80/80.0
LGDVEVNAGQNATFQCIATGRDAVHnklWLQRRNGEDIPvaQTKNInhrrfaaSFRlQEVTKTDQDLYRCVTQSERGSGVSNFAQLIV
  ...|..|.| |. | |.|. ..    .  ...|| ..  |..|.       .|  ..|. .|.. |.|... ..|| .||  .. |
apptvvtegenvtLtCqapgnptpk...vqwykdgeels..qsqna.......lfi.pnvsaedsGtYtCrasnsegskqsnsvevtv
I-set Immunoglobulin I-set domain 201-278 3.1e-09 28.5 Pfam-A 7-81 (90) alignment 
Range on Protein: 201-278
Range on HMM: 7-81/90.0
LGDVEVNAGQNATFQCIATGRDAVHNKlWLQRrnGEDIPVAQTKNINHRRFAASFRLQEVTKTDQDLYRCVTQSERGS
| ||||. |......| ..|    . . |...  |...   |. .....   .......|.. |.. |.|. . . |.
lkdvevseGesvelectveGepepsvs.Wakd..gselkssqrvkvtveeaeytLtIsnvevsDeGkYtckatnsagk
fn3 Fibronectin type III domain 296-370 4.1e-10 32.9 Pfam-A 4-79 (85) alignment 
Range on Protein: 296-370
Range on HMM: 4-79/85.0
APPQLLGVGPTYLLIQLNANSiIGDGPIILKEVEYRMTSGS--WTETHAVNAP-TYKLWHLDPDTEYEIRVLlTRPGE
  ... .|..|.| .. .. .  |.|||   |||||...|.  |.| .. .   ...| .| |.||||.||  .. |.
enlsvsevtstsltlsWsppk.dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVq.avnga
fn3 Fibronectin type III domain 504-582 1.9e-12 40.4 Pfam-A 13-84 (85) alignment 
Range on Protein: 504-582
Range on HMM: 13-84/85.0
ENKIFLNWKEPLDPNGIITQYEISYSSIRSFDpavpvagPPQTVSNLWNSTHHVFMHLHPGTTYQFFIRASTVKGFGPA
.... |.|..| |..| || ||. |.. .. .       ....... ...|.... .| |||.|.| ..| . .| ||.
stsltlsWsppkdgggpitgYeveyrekggge.......ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
0050432 (Phosphotyrosine protein) phosphatases II 887-1178 3.1e-103 340.6 In-house 21-304 (308) alignment 
Range on Protein: 887-1178
Range on HMM: 21-304/308.0
QLHPAIRVADLLQHInlMKTSDSYGFKEEYESFFEGQS-ASWDVAKKDQNRAKNRYGNIIAYDHSRVILqpvedDPSSDYINANYIDIWLyrdgYQRPSH
. .  ..| |||...  .|  |.....||.| ... .   ...||.. .|. |||| .|..||||||.|     |..||||||.|.|..     . .| .
vsslklsvldllkll..ekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgys....sklprk

YIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD----DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPD
.|||||| ..||.|||||.|.... .|||.|.||| ||.||..|||.    ....||.|.||....| |..|.|||..|.  |..| |.|..||.|.|||
fIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpd

HGVPYHATGLLSFIRRVKLSNPPsaGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGET
|||| ... ||.|...|. |.|.  |||||||||| ||||..|..|..|.. |.|| ||....|| ||..| .||||.|||.|...|.|| ... .|
hgvPpspeilldflelvrkslpg..gpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
0045450 (Phosphotyrosine protein) phosphatases II 888-1174 9.9e-100 329.5 In-house 5-305 (307) alignment 
Range on Protein: 888-1174
Range on HMM: 5-305/307.0
LHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQS---ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDD-PSSDYINANYI--DIWLYRDGYQ
|.. |.. .||....|.. .. .|...|.|.... .     ....|.. .|. |||| .|..|||.||.|...... ..||||||.|.  ...|..||| 
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

RPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDD--TEVYGDFKVTCVEMEPLAEYVVRTFTLERR-GYNEIREVKQFHFTG
.. ..|||||| .|||.|||||.|.... .|||.|.||| ||.||..||||.  . .||.|.||....| |..|.|||.....  | .| |.|..||.||
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WPDHGVPYHATGLLSFIRRVKL--SNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGV---VDIYNCVKALRSRRINMVQTEEQYIFIHDAILEAC
||||||| .   ||.||..|.   .. |. ||..|||||| ||||..|....||.. |.||.   ||....|| ||..| ..||..|||.|...|.|| .
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

L
|
l
subfamily_PTPRA_pd Subfamily PTPRA 888-1208 1.3e-99 328.3 In-house 10-330 (330) alignment 
Range on Protein: 888-1208
Range on HMM: 10-330/330.0
LHPAIRVADLLQHINLMKTSDSYGFKEEYESFFEG-QSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHY
 .. . | .| . |.  .. |.  |.||....  |   |. ..|.|..|. |||. ||. ||.|||||...|  ..|||||| .|      |||..  ..
kyfplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfi......dGykekdkf

IATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEV-YGDFKVTCVEMEPLAEYVVRTFTLERRG----YNEIREVKQFHFTGWPD
||.||| .||| |||||||. .|| |||.|.| |  . ||..||||.  | ||. .|.  ... | .| || | ... .     .. | |.|||||.|||
iaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPd

HGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIP
 ||| .. |.|.....||  |. ||||||||||||.|||| .||.| .|.. . |..||... || || .| .||||.||| ||. ..||  | |.| . 
vGvPfepiGmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteld

VCEFKAAYFDMIRIDSQTNSSHLKDEF
|  ..     .    ..|.   |..||
vsslekhlqklynkitgtdkigleeef
subfamily_PTPRK_pd Subfamily PTPRK 889-1210 3.9e-176 579.4 In-house 1-314 (314) alignment 
Range on Protein: 889-1210
Range on HMM: 1-314/314.0
HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGqsasWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHYIA
|||||||||||.|.|.|....|||||||||.|||    ||.||||.||.|||.|.|.|||.|||.|.....|||||||||..|      |.|.||...|.
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaali......dsykrpaafiv

TQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLER--RGYNEIREVKQFHFTGWPDHGVPY
||||..|||.||||....|..|.|||.|.|||||||||.||||.|||||||.||..||.|.|||.|||.|..|.  ||..|||||.||.|.|||||.||.
tqgPlqetvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPv

HATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFK
.|||||...|||| |....||.|||||||||||||..|.|||.|||.|||||||..|.||.||||..|||.|||||.||.|.||||||||||||||.|||
satgllklvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefk

AAYFDMIRIDSQTNSSHLKDEFQT
|.|...||.|.|||||.||.||||
alylesirldpqtnssqlkeefqt
subfamily_PTPRD_pd Subfamily PTPRD 889-1305 2.2e-170 563.0 In-house 2-413 (564) alignment 
Range on Protein: 889-1305
Range on HMM: 2-413/564.0
HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHYIA
...| ||.| .|.. .|..... |.|||... |||. .|..|.|..|.||||| ||.|||||||.|..|| |..||||||..|      |||... .|||
skpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfi......dgyrkrkayIA

TQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYH
||||..||. |||||.|...|..|||.|.|.| |.||| ||||.. || ||...|| .| | ||.|..|||.|..   .| |||.||||| ||||||| .
tqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpes

ATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKA
||.||..||.|. .|.| ||||||||||| ||||..||||.||. .. |..||||..|||||. |  ||||||||||||.|||||  ||.| ... ..|.
atslLdlirkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkq

AYFDMIRIDSQTNSSHLKDEFQTLNsVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITI-DGESSNYINAALMDSYRQPAAFIVTQYPLPNTV
.   . .....|....|. ||| |.  . . ..|. . |  |.|..|||| ..|. ..|   | .| . | |.||||. ...||.  ||| || || |||
hlqkLaeveedtemtgleleFqrLa.takeieleefavatkpknkkknrfsnilalescrvvlsairakeesdyinasyleayrekrafiatqaplkntv

KDFWRLVYDYGCTSIVMLN
.||||.|...  . ||||.
edfwrmvweeevkiivmlt
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 889-1208 1.5e-99 327.9 In-house 3-314 (315) alignment 
Range on Protein: 889-1208
Range on HMM: 3-314/315.0
HPAIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHYIA
|  | . .|. ..   |.|   |||..|||   ||    ||||| .|. |||| ||||||.||| |  .| || |||.|||.|      |||... .|||
hqpipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfi......dGynkkrryia

TQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRgyNEIREVKQFHFTGWPDHGVPYHA
.|||  ..| ||||....|. . |||.|||||  . |. |||||.  .|| . || .. |   || |||..   .  ..|||| |.|.| ||| ||| ..
aqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfg..dnirevvqlhytswpdmgvpkyt

TGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAA
. |. .||.||  .  |.|.|||||||| |||| .| .| .|| || | ..|.|| .. .|. ||.|||. ||| ||.||.||. .||.|.|    .   
iplmnlirtvkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqr

YFDMIRIDSQTNSSHLKDEF
|  ..    .| |. |...|
ydsllapspdtgstllqeqf
subfamily_Ptp69D_pd Subfamily Ptp69D 890-1189 9.4e-88 289.3 In-house 2-302 (307) alignment 
Range on Protein: 890-1189
Range on HMM: 2-302/307.0
PAIRVADLLQHINLMKTSDSYGFKEEYESFF-EGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDiwlyrdGYQRPSHYIA
.|| . || . ..  |    .|...|||.   .  . |  |..|. |  |||| .|.|.|. ||.|.... . .||||||..|       ||.   ..||
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfik......gykekkkfia

TQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP-DDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRG-----YNEIREVKQFHFTGWPDH
 |.|| .|. ||||||.. ..  |||..|| |  | || |||| .|.  |||  |..|. |   .|. |.. . . .      .. |.| |.|.|||.| 
aqdPveatigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDs

GVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPV
 || .|.||| .|..|.  .  . .|||||||||.||.| .. .|..|.  . |  |||.. || |||.|  .||  |||.|.. |.|.    |.| . |
kvPevargllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedv

CEFKAAY
 ... |.
ddledai
0051299 (Phosphotyrosine protein) phosphatases II 891-1173 1.6e-104 344.7 In-house 4-286 (288) alignment 
Range on Protein: 891-1173
Range on HMM: 4-286/288.0
AIRVADLLQHINLMKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHYIAT
.|.| .||.... .. .. .|..||.| ... . . .. .|.. .|. |||| .|..||||||.|........||||||.||      |||... ..|||
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi......dgynlkrkfIat

QGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP-DDTEVYGDFKVTCVEMEPLAEYVVRTFTLERR----GYNEIREVKQFHFTGWPDHGV
||| ..||.|||||.|.... .|||.|.||| ||.||..||| .....|||..||....| |..|.|||.....     | .| |.|..||.|.||||||
qgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgv

PYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEAC
| ... ||.|.|.|. ..... ||.||||||| ||||..|..|..|.. |.||.||... || ||..| .||||.|||.|...|.||..
pdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_PTPRB_pd Subfamily PTPRB 891-1173 7.7e-101 332.0 In-house 6-285 (293) alignment 
Range on Protein: 891-1173
Range on HMM: 6-285/293.0
AIRVADLLQHINLMKTSDSYGFKEEYESFFE-GQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHYIAT
 |.. .. .|.. ||. . ..|.||||.. . |.. . ..|.. .||||||| ||..|||||| |....|...|||||||||      .||. | ..|||
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyi......pgynsprefiat

QGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDD--TEVYGDFKVTCVEMEPLAEYVVRTFTLERrgYNEIREVKQFHFTGWPDHGVPYH
|||..||| |||||.|...|  |||.|.||| |.||| .|||.|  . .||| ||| |. | | ..|.|....|.   .|.|.|.|.||| ||||||| .
qGPlpetvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPek

ATGLLSFIRRVKLS--NPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEAC
.. ||.|.|.|. .  .  |..||||||||| |||| .| .| .|.  |.| .|||.  | .||..| ..||||.||||||...|. .
tktlldfvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 891-1208 4.5e-76 251.0 In-house 4-323 (325) alignment 
Range on Protein: 891-1208
Range on HMM: 4-323/325.0
AIRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYRDgyqrpsHYIATQ
.| | .|..|..  |. |  ||  |..     .. .  || | .|.||||. |..|.|.|||.|.  .||||||||||.|.     .|       ..|.|
siavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkd......vflaaq

GPVHETVYDFWRMI--WQeqsACIVMVTNLVEVGRVKCYKYWPDD---TEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVP
 |  .|. |.||..  |.   . .|.|.| .. |  .| .|||..   .  .| ..|  . .| ...|| | . . .    | | ||||.. .|.| ||.
aPltatindlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvq

YHATGLLSFIRRVKL------SNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETA
 . . |.|... ||       .|  ...||.|||||| |||| .| .  .|.    |  |||.. || ||  | .||.| .|||.|..|. || ..|.| 
krpatlisilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntd

IPVCEFKAAYFDMIRIDSQTNSSHLKDEF
.||. |.|    .   .  |.   .. ||
vpvssfeaklsslqernpltqklniekef
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 892-1211 3.1e-110 363.2 In-house 2-318 (318) alignment 
Range on Protein: 892-1211
Range on HMM: 2-318/318.0
IRVADLLQHINLMKTSDSYGFKEEYESF-FEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHYIATQ
| | || .|.. ...| .  ..|||| .  . .....  . .. |.||||| ||.||||.|| ||..|....|||||||||      |||.|   |||.|
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyi......dGyrrkkayiaaq

GPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHAT
.|. ||. |||||.|. .|| |||.|...| |..|. .|||.. .. ||. .|.  |   |..||.|.|...|.. .| |.|.|.|.| |||.||| ...
aPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesga

GLLSFIRRVKLSN-PPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAA
.||...|.|.  . ...||||||||||| |||| .|..||.|. .. |..||... || ||..|  |||||.||.||.|..|||  .|.| .   .... 
slldlvrqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsr

YFDMIRIDSQTNSSHLKDEFQTL
  .. . |...  .... ||| |
irelreqdpesgttemdaefqrl
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 892-1209 1.1e-107 354.9 In-house 5-319 (319) alignment 
Range on Protein: 892-1209
Range on HMM: 5-319/319.0
IRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHYIATQG
|.|..| .... .... . ....|.. . |... ..| |.|..|. |||| ||.|||..||.|..... ..||||||..|      ||||. . .||||.
ievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfi......dgyqerekfiatqa

PVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDT-EVYGDFKVTCVEMEPLAEYVVRTFTLeRRGYNEI--REVKQFHFTGWPDHGVPYHA
|...|. |||||.|.|.| ..||.|.||| ..||. ||||. . |.|| . ||  | | |..|..| ..| ..  .|.  ||||.|..| ||||.|| .|
PlentiedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpdhdvPeka

TGLLSFIRRVKLSNPP-SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKA
|.|| ...|.. |    ..||||||||||.|||| .||.|.||.  ..|||.|... |. ||  |  |||..|||.||..|.|||  .|.| | | ... 
tslldllkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrd

AYFDMIRIDSQTNSSHLKDEFQ
   ..   ...|  ..|. |||
rlkqlaekvadtgetglerefq
0043336 (Phosphotyrosine protein) phosphatases II 892-1171 5e-101 333.1 In-house 2-275 (278) alignment 
Range on Protein: 892-1171
Range on HMM: 2-275/278.0
IRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHYIATQG
|.| |||.... .. .. .....|.|.. . .  ....|.. .|. |||| .|..||||||.|.... |..||||||.|.      |||..| ..|||||
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv......dgynvprkfiatqg

PVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGL
| .|||.|||||.|.... .|||.|.||| |||||..|||.....||||.||....| |. |.|||......|..| |.| ..|..||||||||.. . |
PlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsll

LSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE
|.|...|.  ...| ||..|||||| ||||..|.....|...|.|| ||....|| ||..| ..|||..||.|...|.||
ldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_PTPRG_pd Subfamily PTPRG 892-1181 3.1e-97 321.1 In-house 1-295 (563) alignment 
Range on Protein: 892-1181
Range on HMM: 1-295/563.0
IRVADLLQHINLMKTSDSYGFKEEYE---SFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSS-DYINANYIdiwlyrDGYQRPSHYI
. | .. .|.  .....  ||.||.|   |    ..   . ..| .|. |||| ||.|||.||| |.|. .  .. ||||||||      ||||.   .|
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyi......dGyqkskafi

ATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLER------RGYNEIREVKQFHFTGWP
|||||...|. |||||||....| |||.||||| || ||  ||| | .| || ..|| .| | || | |||....       .  .. ..|.|.|.| ||
atqgplkdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWP

DHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAI
||||| |..  |.|... . .|.  |||||||||||.|||| |||.| .|   ..| .|.... .| .|..| ..|||||||||.|||.||| . .|| .
dhgvPehslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketel

P
 
l
0039614 (Phosphotyrosine protein) phosphatases II 892-1177 5e-97 320.2 In-house 14-293 (297) alignment 
Range on Protein: 892-1177
Range on HMM: 14-293/297.0
IRVADLLQHINLMKTSDSYGFKEEYESFFEGQSAsWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVED-DPSSDYINANYIdiwlyrDGYQR-PSHYIAT
|..  | ... |.| ........|.|.  . .   . .|.. .|. |||| .|..||||||.|.|... |..||||||.|.      ||| . . ..|||
iplsvldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyv......dgydlltrkfIat

QGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRvKCYKYWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERrgYNEIREVKQFHFTGWPDHGVPYHAT
||| .|||.|||||.|.... .|||.|.||| || ||..|||.....||||.||... | |. |.|||.....  ..| |.|..|..||||||||| ...
qgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppsle

GLLSFIRRVKLSNP--PSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGE
 ||.|.. |.  .   |. ||..|||||| ||||..|....||.. |.|| ||....|| ||..| ..|||..||.|..||.|| .... 
llleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrkl
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 892-1188 2.5e-95 314.2 In-house 4-298 (305) alignment 
Range on Protein: 892-1188
Range on HMM: 4-298/305.0
IRVADLLQHINLMKTSDSYGFKEEYESFFEGqSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHYIATQG
| ..|| ..|. ... .. |....|.|. |  . | || ||..|.||||. .|. .|..|.||.. |... ||||||.|.      |||.|  .||..||
ialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyv......dgykrkkkyivaqg

PVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEV---YGDFKVTCVEMEPLAEYVVRTFTLER-RGYNEIREVKQFHFTGWPDHGVPYH
|...|| ||||.|..|.   |||.|.||| |. ||..|||. .     .|.|.|.  . .  ..|. | ...   .. .| | | |...| |||||||  
PlkntvadfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqf

ATGLLSFIRRVKLSNPPSAG-PIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFK
|| |||.|.||. .   . | |..|||||| |||| .|..||.|. ...|.|||... .|.|||.|..|||| .|| |.|||. |   ||.| | .  ..
atsllslikrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlr

AA
|.
ar
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 892-1174 6e-73 240.2 In-house 2-284 (290) alignment 
Range on Protein: 892-1174
Range on HMM: 2-284/290.0
IRVADLLQHINLMKTSDSYGFKEEYESFFEGQSA-SWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVED--DPSSDYINANYIDiwlyrdGYQRPSHYIA
|.| .. ...   ..    ||.......  |.|  .  |.   .|. .||. ||. ||  |..|.|. .  | . .|||| ||.      ||.   .|||
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyik......gykekkqyia

TQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERRGY-NEIREVKQFHFTGWPDHG-VP
|||||..|. |||..||||....|||.|| .| |.|||..||||  |. || |... .. | | ||. |.. .. .   .. ..|.|...| |...| |.
tqgpvsntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvt

YHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACL
 ..| ||.. ...|    .  ..||||||.. ||.. ...... .. .. |||.|... .| .|. . ..|||..|| .|.. .|..  
npqtillvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyld
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 892-972 1.7e-13 44.7 In-house 6-84 (440) alignment 
Range on Protein: 892-972
Range on HMM: 6-84/440.0
IRVADLLQHINLMKTsdSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYID
| |||. ....  .   |  |..|.  .  | |   |.|   .|. |||| ||.|||||||.|. |.  |.|||||| ||.
iivadfadyvqnnrr..srafedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 892-991 1.4e-11 38.4 In-house 5-95 (95) alignment 
Range on Protein: 892-991
Range on HMM: 5-95/95.0
IRVADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDdpsSDYINANYIdiwlyrDGYQRPSHYIATQG
| |. .  |.  |..     | .|. |      |.. |   . |  |||. ||. || .||.|    |   |||||| ..      ||| |   |||.||
ihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrvvlttkrd...sdyinacfv......dgyarkncyiaaqg
0040438 (Phosphotyrosine protein) phosphatases II 895-1210 1.6e-107 354.7 In-house 3-313 (317) alignment 
Range on Protein: 895-1210
Range on HMM: 3-313/317.0
ADLLQHINLMKTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHYIATQGPVH
 |||....... || ....||.| . . .  ...||.. .|. |||| .|. ||||||.|.|.. |..||||||.|.      ||.... ..||||||  
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv......dgpnlkrkfIatqgPlp

ETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP-DDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLS
.||.|||||.|.... .|||.|.|.| ||.||..||| ..| .||||.||....| ||....||...|  | .| |.|..||.|||||||||.. . ||.
ntvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllld

FIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMI
|...|. ..... ||..|||||| ||||..|....||.. |.|| ||....|| ||..| ..|||.|||.|..||.|| .....| .|..|.| ..  . 
fleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllkll

RIDSQTNSSHLKDEFQT
... ...... . |...
iplalddvklkekelkl
subfamily_PTPN9_pd Subfamily PTPN9 896-1173 5.7e-79 260.2 In-house 5-290 (297) alignment 
Range on Protein: 896-1173
Range on HMM: 5-290/297.0
DLLQHINlmkTSDSYGFKEEYESFFE-GQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHYIATQGPVH
.|.....     .  | ..||.   .   .   ...|.  |  |||| ... ||..|| |. |..|. |||||||..      |||...  .||||||..
elvayvk...ekgkrGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfv......dGykqkkafiatqGplk

ETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGL
.|| |||||.|...   |||.| .|| ||.|| .|||   .... .||..|. ||.|   .|.||......   .|.|.|  | |..|||.|||  |. |
ktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaasl

LSFIRRVKL-------------SNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEAC
| ... |.                .||  ||||||||| |||| .| .|| |.  |..|.||. ..|| ||..|  ..||.||| | . |.||  
ldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 897-1172 7.4e-90 295.9 In-house 2-275 (281) alignment 
Range on Protein: 897-1172
Range on HMM: 2-275/281.0
LLQHINLMKTSDSYGFKEEYESFFE-GQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDiwlyrdGYQRPSHYIATQGPVHE
| .|.. ....|. ||.||||.. . |.. .   .|.|.|. |||| ||.|||..|| ..| |.. ..||||||...      ||. . .|||||||| .
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvp......gykgekeyiatqgPvPa

TVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDT--EVYGDFKVTCVEMEPLAEYVVRTFTLeRRGYNEIREVKQFHFTGWPDHGVPYHATGLLS
....||.|.|...   |||||. .| |..||..|||||.    |||..|. .. |  |.|. |.|.| .|  .| |||.|...| |||||||  .. ||.
slvafWqmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl.eresgetreveqlaytaWPdhGvPattkelle

FIRRV-KLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAERE-GVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEA
| . | ||... .  |.|.||||| ||||.|| .| ... .|.|   .|. . |. || .|  ||||  || |.. |.|.|
frkevlkltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 898-1171 7e-89 292.7 In-house 9-277 (288) alignment 
Range on Protein: 898-1171
Range on HMM: 9-277/288.0
LQHINLMKTSDSYGFKEEYESF-FEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDiwlyrdGYQRPSHYIATQGPVHET
..... .. ..  ||.|||.|    ... | ..... .|  |||| ||..||. || |. .|. ...|||||.|||      |...  .|||||||. .|
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyid......gekkkkkyiatqgPladt

VYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTE--VYGDFKVTCVEMEPLAEYVVRTFTLErRGYNEiREVKQFHFTGWPDHGVPYHATGLLSF
| |||........  |||.|.||| |. || .||||. .   ||...|| || . | ..|.|.. || .  .| .|..|.....|||||||  .. || .
vndfWelvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle.kkkte.leitqyqylaWpdhgvPeskapllel

IRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE
.| || .|.  .|||.|||||| |||| .|..| ..|. |.| ..|. . |. || .| ..|||..||.||....|.
lrqvkvanqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 899-1180 2.3e-102 337.3 In-house 16-297 (298) alignment 
Range on Protein: 899-1180
Range on HMM: 16-297/298.0
QHINLMKTSDSYGFKEEYESFFEGQS----ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDiwlyrdGYQRPSHYIATQGPVH
.  . .|. .  |...|.. . ...|    ....||.|..|. |||| .|||.|.|||.|. ...|  |||||| ...      .|.. . .||||.|..
klaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflh......aykgrnafiatqaPlt

ETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLS
||| |||||...|....|||.|||.|....|. |||||  .| ||...|.  . |  |...||.......  .. |||.|.||| |||.||| .|| .| 
etvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvld

FIRRVKLsNPPSAG--PIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAI
..|.|.  ..  ||  |..|.|||| ||.| .|.|| .|. ...| |||... ||.|| .|...|||||||.||..|.|||  .... |
llrkvra.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 900-1189 1.5e-67 223.0 In-house 10-295 (439) alignment 
Range on Protein: 900-1189
Range on HMM: 10-295/439.0
HINLMKTSDSYGFKEEYESFFEGQSA---SWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHYIATQGPVHET
|.. ..  .   |||..|.    .        .| .. ...|||| .. |.||.||.|| .   | | |||||||      .||  .  ||||||| .||
hvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyi......kGyyddklyiatqgpkket

VYDFWRMIWQEQSACIVMVTNLVEvgrvkCYKYWPDDTEVY-GDFKVTCVEMEPLAEYVVRTFTL--ERRGYNEIREVKQFHFTGWPDHGVPYHATGLLS
. ||||........ |||.|||||      ||||| |.||. ||  | .     | .||.| | .  ||   .  | | |||.. |||. || .|. .| 
tddfwrlviekktvtivmltnlve.....sykywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvld

FIRRVKLSNPP-SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAY
|.| .. .|     ||.||||||| ||||  | .|| |.    |  |||   || || .| .|||.  ||.||..|.||    |..|. . |||  .
flrainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkkef
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 903-1169 2.5e-18 60.5 In-house 19-281 (302) alignment 
Range on Protein: 903-1169
Range on HMM: 19-281/302.0
LMKTSDSYGFKEEYESFfEGQSASWDVAKK-DQNRAKNRYGNIIAYDHSRVILQPVEDdpssDYINANYIDIWLYRdgyqrPShYIATQGPVHETV---Y
|.|. |.   |.|...  . . .. .  |   .| .||.  .. ..|. .|.|.  .|    .|.||  ...   .     .|  | .| |. ...    
lvksldtaevkkefkki.dtmkvdlekCkafkknlkknqsedvpildsnlvkleaepd....syvnaskvevPelt.....rs.iilaQlpkvdsedsve

DFWRMIWQEQSACIVMVTNLVEVGRvKCYKYWPDDTEVYGDFKVTCVEMEPL---AEYVvRTFTLE--RRGYNEIREVKQFHFTGWPDHGVPYHATGLLS
.||||..||. . .|..    |. .    ...|  .. | ...   |         | .   ...|    |. .   ..  ..| |... || . . |  
eFWrmvfqekivsvvilvgeeelkk.tlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaelik

FIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAI
 .  |  .. ..  ..|.    |||| |  ..  . ..  ...  . | . ||..|| | ..|.. .||.... |.
taakvfakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyial
0036941 (Phosphotyrosine protein) phosphatases II 904-1190 6.2e-101 332.9 In-house 7-294 (297) alignment 
Range on Protein: 904-1190
Range on HMM: 7-294/297.0
MKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGNIIAYDHSRVILqpveDDPSSDYINANYIdiwlyrDGYQRPSHYIATQGPVHETVYDFWR
.| ........|.|.... . . |..||.. .|. |||| .|..|||.||.|    ||..||||||.|.      |||... ..|||||| ..||.||||
ekllflalllkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyv......dgydlkrkfIatqgPlpntvedFWr

MIWQEQSACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCVEMEP--LAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRR
|.|.... .|||.|.||| ||.||..|||   ... .||||.||....|   |..|..||....  |..| |.|..||.||||||||| ... ||.||..
mvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfiel

VKL--SNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAE---REGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYF
|.   .. || ||..|||||| ||.|..|..|.||.. |   .|| |||...|| ||..| ..|||.|||.|...|.|| .....| .|..... ...
vrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvllll
0047943 (Phosphotyrosine protein) phosphatases II 904-1172 3.1e-96 317.3 In-house 6-271 (273) alignment 
Range on Protein: 904-1172
Range on HMM: 6-271/273.0
MKTSDSYGFKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGNIIAYDHSRVILqpveDDPSSDYINANYIdiwlyrDGYQRPSHYIATQGPVHETVYDFWR
.| .......||.| ... . . .. ||.. .|. |||| .|..||||||.|    .|..||||||.|.      |||... ..||||||  .||.||||
ekllgltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyv......dgynlkrkfiatqgPlpntvedfwr

MIWQEQSACIVMVTNLVEVGRVKCYKYWPDD----TEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRV
|.|.... .|||.|.||| ||.||..|||..    ...||.|.||....|  . |.|||..|.. |..| |.|..||.||||||||| . . ||.||. |
mvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

KLSNPP--SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEA
.  .    | ||.||||||| ||||..|..|..||. |.|| ||....|| |||.| .||||.|||.|...|.|| 
rkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_PTPN6_pd Subfamily PTPN6 905-1170 6.3e-87 286.4 In-house 21-294 (306) alignment 
Range on Protein: 905-1170
Range on HMM: 21-294/306.0
KTSDSYGFKEEYESFFEG---QSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQpVEDDPSSDYINANYIDiwlyRD----GyqrpSHYIATQGPVHETV
.. .  ||.||.|.. .    .  | . ..| .|. |||| ||. .||.||||.  .. | |||||||||.    ..          .|||||| ...||
eslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyik....kevkgsd....ksyiatqgclettv

YDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDD--TEVYGDFKVTCVEMEPLAEYVVRTFTLE-RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSF
 |||||.|||.|  |||.|. || |. ||..||||   .| ||. .||.|. . ||.|..|..... ..  .| ||| |.||. ||||||| .   .|.|
sdFWrmvwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdf

IRRVKLSNPPSA----GPIVVHCSAGAGRTGCYIVIDIMLDMAEREGV---VDIYNCVKALRSRRINMVQTEEQYIFIHDAIL
.. |.  .  ..    |||||||||| |||| .|||||.|.. |..|.   .||...|| .|. |  .||||.|| |.. || 
ledvnrkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 905-1211 1.2e-63 209.9 In-house 15-274 (392) alignment 
Range on Protein: 905-1211
Range on HMM: 15-274/392.0
KTSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDiwlyrdGYQRPSHYIATQGPVHETVYDFWRMI
|   |  | ||.  . . .     ||.|. |  ||||.||. || .||.|. ..| | |||.|| ||.      ...    |||.|||   .. |||||.
knrhsalffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyip......sfdnekayiasqgpnaaslddfwrmv

WQEQSACIVMVTNLVEVGrvkcykywpddtevygdfkvtcvemeplaeyvvrtftlerRGyNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP
.||. . |.|||.| |                                          .| .. | | ||||| |||..|| |.. || ||. ||     
fqenvttiamvtklkegd........................................kg.ddartvaqfhftewPdkdvpkhtssllkfikevkadfGq

SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHL
 . |...||||| ||||  | || ..  |..  .||..| |  .| .|  ||||.||| ||. |.||  |  .| |||  |     |.         |. 
ythpliihcsagvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGdvrskq

KDEFQTL
  ||..|
lkefrsl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 905-1175 1.3e-63 209.5 In-house 12-295 (301) alignment 
Range on Protein: 905-1175
Range on HMM: 12-295/301.0
KTSDSygFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVED--DPSSDYINANYIdiwlyrDGYQRPSHYIATQGPVHETVYDFWR
| |..  |.|.|..  ||.. | .|  ...|.| ||. ||  ||. |.||.| ..    . .||||.||      |||..  ..||.|||...|. ||||
khsnk..feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyi......dgysekkkfiaaqgpmkktlvdfWr

MIWQEQSACIVMVTNLVEVGRVKCYKYWPD---DTEVYGDFKVTCVEMEPLAEYVVRTFTLE-RRGYN--------------EIREVKQFHFTGWPDHGV
.||||. . ||||||| |  . ||..|||.   ..| .| |.|| |.   . ..|.| ...  . | |              . ..| |.. | ||..||
liwqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGv

-PYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLC
 . ..| | .    ..  . .. ||.|||||.. .|.| |. ..| |. . .|||||... .||.|  .  .|.| |||..|.|.| .   .
vreprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylql
subfamily_PTPN14_pd Subfamily PTPN14 905-1170 9.9e-60 197.0 In-house 19-293 (300) alignment 
Range on Protein: 905-1170
Range on HMM: 19-293/300.0
KTSDSYGFKeEYESFFE-GQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDpSSDYINANYIDIWLyrDGYQrpSHYIATQGPVHETVYDFWRM
| ...  |. |||   .  . |  ..|| ..|  |||. ... |...|| |.| ... |..||||  | . .   | .   .||..|||.. || |||.|
kleegkvft.eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsv..ggke..rsyivaqgPleltvqdfWqm

IWQEQSACIVMVTNLVEVGRVKCYKYWPDD-----TEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRV
.|... . |||.|.  | |. |..||.|..     |  .| ||||    |    .. ....|.    .| |.|  . .| |||||||   .| ||....|
vWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeev

KL-------SN--PPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAIL
.        ..    |  |..||||||.||||  |. |...   | . ..|| . .. || .|  .|||  || |......
qsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 906-1211 2.1e-84 278.1 In-house 15-315 (315) alignment 
Range on Protein: 906-1211
Range on HMM: 15-315/315.0
TSDSYGFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDiwlyrdGYQRPSHYIATQGPVHETVYDFWRMIW
   .  | ||.  . . .     ||....|  ||||.||. .|..||.|. ..|.| |||||| ||       ...    |||.||| . .| |||||..
nrhtalfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyik......svdddkayiasqgPlkasvddfwrmvl

QEQSACIVMVTNLVEVGRVKCYKYWPD---DTEVYGDFKVTCVEMEPLAEYVVRTFtLERRGyNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSN
||. . |||||.. |  ..|| .||||   |.  .| .||. ...|. .. |.| .   |.. .| | | ||.||.|||.||. ... || .|. || .|
qekvttivmvtkkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrks.eesrtvtqfqftewPdkGvdkqtssllklikevkadn

PPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSS
 .   ...||||||.||||  | || ... ..|. .||..| || ||. |. .|||||.| ||.||.||  |  .| |.|  |     |.    . .  |
gkkefsllvhcsaGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrs

HLKDEFQTL
.. .||.||
kmtkefetl
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 910-1179 1.1e-71 236.2 In-house 20-284 (287) alignment 
Range on Protein: 910-1179
Range on HMM: 20-284/287.0
YGFKEEYESFFE-GQ-SASWDVAKKDQNRAKNRYGNIIAYDHSRVILQpvedDPSSDYINANYIdiwlyrDGYQRPSHYIATQGPVHETVYDFWRMIWQE
 |||. .  . . .|   .  ..   ||. |||. .|. .|  ||.|.    .   ||||| .|      |||.   ..|....|. .|. .||..|...
egfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfi......dgykekkafiiaesPmfntarnfWkliddr

QSACIVMVTNLVEVGRVKCYKYWPDDT-EVYGDFKVTCVEMEPLAEYVVRTFTLERRG-YNEIREVKQFHFTGWPDHG-VPYHATGLLSFIRRVKLSNPP
.   |||.... |  . .||.|||...  |.|..... .. |  |.|..|.. .....  .. ..|||...| |...| |. ..| || . ...|    .
nvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkr

SAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETA
. ..||||||.. ||.. .. ... .. ...|||.|... .|  | .. ..||| |||.|| |..||   ..|| 
gntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
0045098 (Phosphotyrosine protein) phosphatases II 911-1176 3.6e-83 274.4 In-house 9-275 (278) alignment 
Range on Protein: 911-1176
Range on HMM: 9-275/278.0
GFKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVIlqpveddpssDYINANYIdiwlyrDGYqrPSHYIATQGPVHETVYDFWRMIWQEQSA
 . | .. .  |.  .. .| .  |..|||| .|..||||||.          |||||.||      |||  | ..||||||  .|| |||||.|.... 
lllefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyi......dgy..pkkfIatqgPlpstvadfwrmlwelgit

CIVMVTNLVEVGRVKCYKYWPDDT-EVYGDFKVTCVEMEPLAEYVVRTFTLERR----GYNEIREVKQFHFTGWPDHGVPYHA--TGLLSFIRRVKLSNP
.|||.|.||| ||.||..|||..  ..||||.||....| | .|..||....       ..| |.|...|...||||||| .   . .|.......  . 
vivmltelvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealk

-------------PSAGPIVVHCSAGAGRTGCYIVIDIMLDMAerEGVVDIYNCVKALRSRRIN-MVQTEEQYIFIHDAILEACLCG
             .| ||..|||||| ||||.......||..   ||.||....|| |||.| . .||..|||.|.....||  |.|
llaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
0046845 (Phosphotyrosine protein) phosphatases II 912-1180 1.3e-99 328.4 In-house 2-281 (284) alignment 
Range on Protein: 912-1180
Range on HMM: 2-281/284.0
FKEEYESFFEGQSA---SWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDD-PSSDYINANYIdiwlyrD-----GYQRPSHYIATQGPVHETVYDFWR
..||.|     .     |..||.. .|. |||| .|..||||||.|.....| ..||||||.|.      |      . .. ..||||||. .||.||||
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyv......dgydldltyikkkfIatqgPlpntvedFwr

MIWQEQSACIVMVTNLVEVGRVKCYKYWP--DDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRG-YNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVK
|.|.... .|||.|.||| ||.||..|||  ... .||||.||....|    |.|||..|.. |  .| |.|..||.|.||||||| ... ||.|.| |.
mvweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvr

LSNP--PSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREG---VVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAI
 ...  |. |||||||||| ||||..|..|..|.. |.||   .||....|| ||..| .||||.|||.|...|.||..... | .
ellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltll
DSPc_SM00195 912-1172 4.7e-92 303.4 In-house 2-261 (263) alignment 
Range on Protein: 912-1172
Range on HMM: 2-261/263.0
FKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWlyrdgyQRPSHYIATQGPVHETVYDFWRMIWQEQSA
.|||.|.  | . . . . |.|..|..|||| ||. |||.||.|.. |....|||||||||..       .....|||||||  .|| |||||.|.|.. 
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga......nkkkkyIatQgPlpstvedFWrmvweekvk

CIVMVTNLVEVGRVKCYKYWPDD---TEVYGDFKVTCVEMEPLA-EYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSA
.|||.|. .| |. ||..|||..   .|..|...|..|| |    |...||..|.  | .| |.|.|.....||||||| ... .|...| || |.  | 
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstss

GPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEA
|||||||||| ||||....|||.|.  |.|  ||| ..||.||. |..||||.|||.||..||||.
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 912-1172 4.7e-92 303.4 In-house 2-261 (263) alignment 
Range on Protein: 912-1172
Range on HMM: 2-261/263.0
FKEEYESFFEGQ-SASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWlyrdgyQRPSHYIATQGPVHETVYDFWRMIWQEQSA
.|||.|.  | . . . . |.|..|..|||| ||. |||.||.|.. |....|||||||||..       .....|||||||  .|| |||||.|.|.. 
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga......nkkkkyIatQgPlpstvedFWrmvweekvk

CIVMVTNLVEVGRVKCYKYWPDD---TEVYGDFKVTCVEMEPLA-EYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSA
.|||.|. .| |. ||..|||..   .|..|...|..|| |    |...||..|.  | .| |.|.|.....||||||| ... .|...| || |.  | 
iivmlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstss

GPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEA
|||||||||| ||||....|||.|.  |.|  ||| ..||.||. |..||||.|||.||..||||.
gpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 912-1220 4.3e-85 280.7 In-house 20-323 (515) alignment 
Range on Protein: 912-1220
Range on HMM: 20-323/515.0
FKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDiwlyrdGYQRPSHYIATQGPVHETVYDFWRMIWQEQSAC
| ||.  .   .     ||... |  ||||.||. || .||.|. ..|.| |||.|| ||       ...    |||.||| . .| ||||...||. . 
fseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyip......sfdndkayiasqgPnkasvddfWrlvlqenvtt

IVMVTNLVEVGRVKCYKYWPD---DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRgyNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGP
|.|||.| |  ..|| |||||   |.  .| .||  | .|  .. . |..|. .   ...| | |||||.|||.||| |.. || .|. || ..   . |
iamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkg..ddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythp

IVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEF
...|||||.|||| .| || ..  |.   .||..| |. .| .|  .|||.||| ||..|.||  |  .| |||  |     |.         |.. .||
liihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkef

QTLNSVTPRLQA
|||.|..|   |
qtlkslcpdppa
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 912-1185 3.2e-71 234.9 In-house 28-296 (297) alignment 
Range on Protein: 912-1185
Range on HMM: 28-296/297.0
FKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDIWLYrdgyqrpsHYIATQGPVHETVYDFWRMIWQEQSAC
|.||.    | .  .  ||.|  |  |.|| ||. || |||.|. |.|||.|||.|| ..    .        ..|.|| | ..|| |||.|...|| . 
fseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh........rlittqmPmkatvadfWamvldeqvst

IVMVTNLVEVGRvKCYKYWPDDTE-VYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPY--HATGLLSFIRRVKLSNPPSAG-
|||.... |  . || .||.|..   .||  |.   ..    .. |......      | |||..|. |||. |.   .|. || .|  |. .    |  
ivmlnddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg

PIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEF
|..|||.|| |||| .. || ..  |.||  |||.. || ||  | ..|||.||| |.. |.||| |. .|.|..  |
PllvhclaGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 912-1171 2.6e-48 159.2 In-house 33-281 (290) alignment 
Range on Protein: 912-1171
Range on HMM: 33-281/290.0
FKEEYESFFEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQpveDDPSSDYINANYIDiwlyrdGYQrpSHYIATQGPVHETVYDFWRMIWQEQSAC
. |.   .. .|    ..  |. .  |||| ...  | .||||.   |    ||. |||..      | .  . .| |||....|| |.|||. ||. | 
yleklkpylpvqylerkifdkntefkknrykdvvcndktrvilk...dGydGdyvhanyvk......Glk..amfiltqGalkdtvidiwrmvlqekvaa

IVMVTNLVEVGRVKCYKYWPDDT---EVYGDFKVTCVE-MEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLsnppSAG
|||. .|.| |. || .|.|.       .|.. |.| |  .. |. . .|...  .       .| ..   |||. |.  .  ||  .| ..      .|
ivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrk....asG

PIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE
|.||||||| |||| .. |.. |..      .|. . |.|||  |.| || . ||. . ...|.
pvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 913-1171 5.3e-47 155.1 In-house 10-293 (297) alignment 
Range on Protein: 913-1171
Range on HMM: 10-293/297.0
KEEYESFF-EGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEddPSSDYINANYIdiwLYRDgYQRPSHYIATQGPVHETVYDFWRMIWQEQSAC
..|..... | .. |. .||..    |||| .|.|.| .|| |. |   . .|||||.|.    . |  . . .|| .|||...|| |||.......   
eaekdllldeargesfssakrnsslrknryrdilatddtrvkllrvi..terdyinadyv...vfpd.eeadlkyilaqGplsatvddfwtlvaeqdvrv

IVMVTNLVEVGRVKCYKYWPDDT---EVYGDFKVTCVEME--PLAEYVVRTFTLERRgyNEIREVKQFHFTGWPDHGVPYHATGL---------------
||||..| | || ||. |||.        ||. |  .          ..  ..|  |  .| | |.   | .|||||||     |               
ivmvaklqedGrdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavp

--LSFIR--------RVK--LSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE
  |. .         ...   .. |   ...|||||| ||.|  .  |..|..  .. . |.   .. ||..|  .||| ||. ...||.|.
mmlalvemftamvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_ptpA1_pd Subfamily ptpA1 913-1131 2.5e-41 136.8 In-house 24-254 (418) alignment 
Range on Protein: 913-1131
Range on HMM: 24-254/418.0
KEEYESFFEGQSASW-DVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDiwlyrdG-YqrPSHYIATQGPVHETVYDFWRMIWQEQSA
|||.  . |    |      | .| .|||| ||.  .|.|| |. ..|   ||||||||||      | |  | ..|.||||. .|. |||||.|...  
keefrlleesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyid......gay..pkqfictqgplpntiadfwrmvwenrcr

CIVMVTNLVEVGRVKCYKYWPDD------------TEVYGDFKVTCVEM--EPLAEYVVRTFTLERRGynEIREVKQFHFTGWPDHGVPYHATGL---L-
 |||..   |  |.|| .|||..             ||.| . |  ||.  .|  | . |   |   |  | |.. |... ||||| .| |.  .   | 
iivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfeg..etrditqyqyegwpdhnipdhtqpfrqllh

SFIRRVKLSNPPS--AGPIVVHCSAGAGRTGCYIVIDIMLD
|   | .   | |    ||.|||||| |||| .    ||. 
sitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk
subfamily_PTPN13_pd Subfamily PTPN13 915-1172 7.3e-75 246.7 In-house 16-268 (273) alignment 
Range on Protein: 915-1172
Range on HMM: 16-268/273.0
EYESFFEGQS-ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQpveDD-PssdYINANYIDIWLYRDGYqrpsHYIATQGPVHETVYDFWRMIWQEQSACI
|.. . | ..  . .|.||..|..|||| |.. ||..||.|.   |. .   ||||..| . .  | |    .|||.|||. ||| |||.|.|. ..  |
efkelrelkpldtcevgkkkenkdknryrnvlPydetrvklg...degg...yinaslikvpvgkdey....eyiacqGPlPetvkdfwqmvweqkaevi

VMVTNLVEVGRVKCYKYWPDDT----EVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPpSAGP
.|||. .| |.||| .|||. .     |.. ..|. .... | ..|||.....    .| ||| ...|. ||||||| .|. || |...|.  .  .|||
amvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagP

IVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEA
|||||||| ||.| .|.||..|.. ||.  .|. . |. || .|  .|||..||||.. ||||.
ivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_PTPRN_pd Subfamily PTPRN 920-1171 2e-62 205.6 In-house 41-290 (297) alignment 
Range on Protein: 920-1171
Range on HMM: 41-290/297.0
FEGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLV
.| . .. .|||...|  |||. ....|||||| |.   .. .||||||  |      |   | . |||||||. .|| |||.|.|.. .. ||..|.| 
yeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasai.....ldhdprapayiatqgplastvadfwqmvweqGvvvivnltrle

EVGRVKCYKYWPDD-TEVYGDFKVTCVEMEP-LAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGA
| |  .|..||||. .|||. ..|  |       .|.||.| |     .| | | ||||  ||..|||  |  || | |.|  |    . |||||||.||
eegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcsdGa

GRTGCYIVIDIMLDMA-EREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE
||||.||.||..|.        .||   .. || .| ..|.|..|. |.  |. |
GrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 921-1170 3.1e-58 191.8 In-house 24-274 (287) alignment 
Range on Protein: 921-1170
Range on HMM: 24-274/287.0
EGQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQpVEDDPSSDYINANYIDiwlyrdGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVE
|. .| .  |..  .  ||||.... .|..||.|   | .  ||||||||.       .|..   .||.|||.  || ||||......|| ....|  ||
esstatfkaaeelaavkknryadvlPiddtrvlls.aegelGsdyinanyva......sytddeafiaaqgPiaatvrdfwravletrsasvitmtreve

VGRVKCYKYWPDDTE--VYGDFKVTCVEMEPL-AEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRV----KL-SNPPSAGPIVVH
 .| |||||||.       | . |. .. . .  || ||.. |     .| | |||...  |||....  | ||. |.  |    .|  .   .||.|||
earlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvh

CSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAIL
...|.||.| .. . ..... |  | ||. . |  || .|  .||.  |. .. .|. 
ddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 922-1170 7.4e-37 121.5 In-house 39-287 (310) alignment 
Range on Protein: 922-1170
Range on HMM: 39-287/310.0
GQSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQpVEDDPSSDYINANYIDIWLYRdgyqrpSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEV
 | .|       ..  |||| ...  | ||| |. ..     ||| |||.     |      | .| .|||.  |. ||||||.||..  |... . .| 
kqdssltyeaykkymhknrysdvvcldtsrvklk.idksryedyihanyvktnylr......stficsqgplqhtiidfwrmifqeraesilllckvgee

GRVKCYKYWPD--DTEVYGDFKVTCVE-------MEPLAE-YVVRTFTLERRGYN-EIREVKQFHFTGWPDHGVPYHATGLLSfiRrvKLSNPPSAGPIV
|| ||  |||    || ||  .|| .        .  ||  .|     .. .  | .   |.  ..  ||| |||      .   .  .|      || |
grpkcvgywpslgvtetygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvp..q..rllaqvrhgpcv

VHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAIL
|||||| .|... . ... .| ..|   ||. . .  |. .|.  .||| ||..|.   .
vhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvri
subfamily_PTPN12_pd Subfamily PTPN12 923-1173 3.2e-77 254.3 In-house 28-277 (290) alignment 
Range on Protein: 923-1173
Range on HMM: 28-277/290.0
QSASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDiwlyrdGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVG
.  | ....|..|..|||| .|. ||.||| |.  |... |||||||.|       | . . .|||.|||. .|. |||||||. .   .||. ..||.|
kvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfik......gvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelg

RVKCYKYWPDDT--EV-YGDFKVTCVEMEPLA-EYVVRTFTLERRgyNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAG
. || .|||. .  |. .|.|.||. | . .  ....||...|..  .| |.|.|||.| |||||||  |. ||..|. |.  .  .. |.||||||| |
kkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvG

RTGCYIVIDIMLDMAEREGV---VDIYNCVKALRSRRINMVQTEEQYIFIHDAILEAC
|||  |.||.. .. ..| .   .|... |  || .|  .|||.||| ... |..| .
rtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN3_pd Subfamily PTPN3 924-1172 6.1e-77 253.3 In-house 30-274 (280) alignment 
Range on Protein: 924-1172
Range on HMM: 30-274/280.0
SASWDVAKKDQNRAKNRYGNIIAYDHSRVILQpveDDPSsDYINANYIDIWLyrDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGR
. . ..|.| .| .|||| .|..||. ||.|.   . .. |||||||... .  .. .   .|||||||...|. |||.|.|...|  |||.|.||| ||
glaisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmei..pstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGr

VKCYKYWPDDT--EVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTG
|||..|||. .    ||.|.|.| . .   .||.| ..|...  .| |.. |. .. ||||||| ... .|.|..||.     .  |.||||||| ||||
vkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtG

CYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEA
 .|.... | . |..  | . . |. .| .| ..|||..|| |. .|||..
vlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
subfamily_PTPN1_pd Subfamily PTPN1 925-1174 5.4e-63 207.4 In-house 22-272 (290) alignment 
Range on Protein: 925-1174
Range on HMM: 22-272/290.0
ASWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDdpssDYINANYIDIwlyrDGYQRpsHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRV
 .  .||...||..||| ..  |||||..|.  .     |||||. ...    .  .|  .|| ||||. .||  ||.|.|...| ..||. ..|| ...
fptreaklpenrnlnryrdvspydhsrikleradn....dyinaslvel....eeakr..syiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqi

KCYKYWPDDTE---VYG---DFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSN--PPSAGPIVVHCSAG
||..||| . |   .      .||. .. |   .|.||.. || .  .| ||. .||.| ||| |||   . .|.|. .|. |    .  || |.|||||
kcaqywPqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssdvGpavihcsaG

AGRTGCYIVIDIMLDMAEREGV---VDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACL
 ||.| ....| .|   |...    ||| . . .||. |. ..|| .|  | . ||||   
iGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 926-1189 7.7e-83 273.4 In-house 52-307 (319) alignment 
Range on Protein: 926-1189
Range on HMM: 52-307/319.0
SWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTnlvevgRVK
  . |  |||. |||..||.|.|...| |....    |||||| ..      .||||.  |||.|||  .|. |||||||. ... ||..|      . |
dqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfv......tGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdk

CYKYWPDDT-EVYGDFKVTCVEMEPLAEYVVRTFTLERRG-YNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKL--SNPPSAGPIVVHCSAGAGRTG
| .||| .. . .. |||    .|  |||||| . | . |  ..||...|||| ||||.||| ... |. ....|.   |      .||||||||.||||
csqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtG

CYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAAY
 |||.|..||. ..|  ||.|| |. || .| ..||   || ||. |.||  | | . . . .| | .
vyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayl
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 926-1171 2.5e-65 215.1 In-house 11-262 (270) alignment 
Range on Protein: 926-1171
Range on HMM: 11-262/270.0
SWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDiwlyrdGY-QRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRV
. |. .  .... ||| .|.   ..||.|...|.|. . ||||||.       |. ... .|||..||.  |. .||||||.|.. .|||.|.|.| || 
esdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvr......GfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrk

KCYKYWPDDTEV-----YGDFKVTCVEMEPLAEYVVRTFTLERRGynEIREVKQFHFTGWPDHGVPYHAT------GLLSFIRRVKLSNPPS--AGPIVV
|| .||| ...      .|. ||. .. |    |...  .||..|  |.|..  |... ||||||| ..        ||. .| |. |.     |.|..|
kCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekg..eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePllv

HCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE
||||| ||||. |..||.. . |... ||. . ...||  |...||. ||| |.. |..|
HcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavve
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 926-1186 1.1e-61 203.2 In-house 24-279 (283) alignment 
Range on Protein: 926-1186
Range on HMM: 24-279/283.0
SWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDdpssDYINANYIDIwlyRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVK
. |.|  |.|. |||. .|...|  || |..       ||||| .| .    . |..   ||..|.|...|| |||.|...|. ..|||.|.| |  |.|
dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipv...sksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrik

CYKYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERR--GYNEIReVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGC
| .||| . .| ||.| ||  .      .... ..|       ...  .  . . .| . |       |. | . . | .    ||||||||.| |||. 
CsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtav

YIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFK
.| .   .. |  | |||... || .| .|. .||| .|| ..|...|| .|||.| |  ... 
fiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlq
0049772 (Phosphotyrosine protein) phosphatases II 926-1175 1.7e-41 138.3 In-house 37-282 (314) alignment 
Range on Protein: 926-1175
Range on HMM: 37-282/314.0
SWDVAKKDQNRAKNRYGNIIAYDhSRVILqPVEDDPSSDYINANYIDIWlyrdgyqrpSHYIATQGPVHETVYDF----------WRMI--WQEQSACIV
.. ||..  || |||| .|. .| .|||| | ..  .||||||.|.|             .||||||  .||.||          |||.  .. ..  ||
tilvadlflnrdknryldilpad.nrvil.pglpvsgsdyinasyvdgf.........lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdiv

M---------------------VTNLVEVGrvkcykywpdD------TEVYGdfkvtcvemeplaeY-------VvrtftlerrgyneIREVKQFHFTGW
|                      ..| . |          .       | .                       .              |.. ... . .
msrdevladelsrLdaAlgKtpllildgng..........neptaadlellk..............eelydpelf.............erlgikylripv

PDHGVPyHATGLLSFIRRVKLSnpPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAereGVvDIYNCVKALRSRRI-----NMVQTEEQYIFIHDAILEACL
||...|     ...|.. ..    .  ||..|||.|| ||||...|.....      || ..  ... .|..|      ..... |||.||..|.||.. 
pDgsap.lledfdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylk

C
 
f
subfamily_egg_pd Subfamily egg 926-1170 9.3e-27 88.5 In-house 31-267 (307) alignment 
Range on Protein: 926-1170
Range on HMM: 31-267/307.0
SWDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDiwlyrdGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVgrVK
|   | .| |. | |   .   | ||| |.  .   . |.| ||...      |     ..| .| |. .|| |||||..||.   |||.|  .|    .
slttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvk......Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..er

CYKYWPD---DTEVY--GDFKVTCVEMEPLAEYVVRTFTLERRGYNeiREVK-QFHFT-GWPDHGVPYHATGLLSFIRRvklsnppSAGPIVVHCSAGAG
|  |||    |. |.  | .........  |. . |   |   | .  .| .   |.   .   .  |    .|  .|.        . |.||..  |  
ceyywpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd..deerflehwqgdvnnssdvysplrvlrklrn.......lskpvvvqdilGvs

RTGCYIVIDIMLDMAEREGVV--DIYNCVKALRSRRINMVQTEEQYIFIHDAIL
.... . |.| |    |  ..   . ..|. || ||   |..  .|.|..  .|
kaatlvaieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
0040439 (Phosphotyrosine protein) phosphatases II 927-1174 1.6e-87 288.5 In-house 3-247 (249) alignment 
Range on Protein: 927-1174
Range on HMM: 3-247/249.0
WDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKC
..||..  |. |||| .|..||||||.|..... . ||||||.||      |||... ..|||||| .|||.|||||.|.... .|||.|.||| ||.||
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi......dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekc

YKYWP-DDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKL--SNPPSAGPIVVHCSAGAGRTGCY
..||| ... .||||.||....| ...|.|||..|.. ...| |.|.....|.||||||| .   ||.||..|.   .. |. ||..|||||| ||||..
aqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtf

IVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACL
|....||.. |.|. ||....|| |||.| ..||..|||.|...|.|| .|
iaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
0037934 (Phosphotyrosine protein) phosphatases II 927-1171 4.1e-81 267.4 In-house 2-240 (243) alignment 
Range on Protein: 927-1171
Range on HMM: 2-240/243.0
WDVAKKDQNRAKNRYGNIIAYDHSRVILqpveDDpsSDYINANYIDIWlyrDgyqrpsHYIATQGPVHETVYD----FWRMIWQEQSACIVMVTNLVEVG
. .|.. .|. |||| .|..||||||.|    ..  |||||||.|...   .      ..||||||  ||| |    ||||.|.... .|||.|.||| |
fsiallpenlsknrysdilpydhsrvkl....eg..sdyinanliyvt...p......rliatqgPlpetveddlasfwrmlwelgitvivmltelvElg

RVKCYKYWPDDTeVYGDFKVTCVEMEPLAEYVVRTFTLERRG-YNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLS--------NPPSAGPIVVHC
|.||..|||... .||||.||....| |..|.|||..||. . ... |.| ..|...||||||| . . ||.|.. |.          . .| ||..|||
rekcaqywpgev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHC

SAGAGRTGCYIVIDIMLDMAereGvVDIYNCVKALRSRRIN-MVQTEEQYIFIHDAILE
||| ||||..|....||..    | ||....|| ||..| . .|||..||.|...|.||
saGvgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 927-1171 1.7e-40 133.5 In-house 29-267 (281) alignment 
Range on Protein: 927-1171
Range on HMM: 29-267/281.0
WDVAKKDQNRAKNRYGNIIAYDHSRVILQP-VEDDPSSDYINANYIDIWLYRDGyqrpshYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVK
  | ..  |  |||| || . | ||| |.  . .  |.||| ||||   . . |      || |||| .||  |||||||||....|||. ...|  | |
ctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrg......yiltqgpkketradfwrmiwqenttaivmlcqfletnrek

CYKYWPDDTEVYGDFKVTCVEMEPLA-EYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSnppsAGPIVVHCSAGAGRTGCYI
| .|.| .. .  .|    |. |  . .  . |  |.     | | . .. .  |||  ||  .  .|  .|...      . | |.||||| ||.|  .
caeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkirar....stppvihcsagvgrsgtlm

VIDIMLDMAE-REGVVDIYNCVKALRS-RRINMVQTEEQYIFIHDAILE
 ..| |.    .  . || . |  ||   |   ||| .||..|   .|.
aveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 927-1033 8.7e-16 52.2 In-house 40-156 (349) alignment 
Range on Protein: 927-1033
Range on HMM: 40-156/349.0
WDVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDP--------------SSDYINANYIDIWLYRDGYqrpsHYIATQGPVHETVYDFWRMIWQEQSACI
  ...  .  ||||| .|. |.||||.|.     .                |||||||. .  .        .||||| |.  || ||...|  ..   .
vilseGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvek....kyiatqaPlPstvddfykvillngvklv

VMVTNLVEVGRVKCYKYWPDD
. ...  | .  ||..|| . 
lsLnddkelslekcdiywqel
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 928-1175 4.5e-91 299.5 In-house 2-244 (250) alignment 
Range on Protein: 928-1175
Range on HMM: 2-244/250.0
DVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDiwlyrdGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVkCY
.|||| ||. |||| .|||.|.|||.|.... |  |||||| ...      ||.  . .||||||...|. |||||...|.|. |||.|||.| ... . 
svakkpqnkeknryadiialdssrvvLekekgdkesdyinasflh......gyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yh

KYWP-DDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP-SAGPIVVHCSAGAGRTGCYIV
.||| . .| ||| .|.  . |  |.|..|.. | ..  .. | |.|.||. ||| ||| .||  | ....|. |..   ..|..|.|||| ||.|..|.
qywPvekaekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafia

IDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLC
|| .|. ...| |||... .|.||  |...|...|||.|.. .||.|  .
idavlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
0042113 (Phosphotyrosine protein) phosphatases II 928-1171 2.1e-86 284.6 In-house 2-241 (245) alignment 
Range on Protein: 928-1171
Range on HMM: 2-241/245.0
DVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCY
.||..  |. |||| .|..|||.||.|.|.. |. ||||||.|.      |||... ..|||||| .||| |||||.|.... .|||.|...| |||||.
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyv......dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkca

KYWP-DDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNP-PSAGPIVVHCSAGAGRTGCYIV
.||| ... .||||.||....| |..|.|||..... |..| ||| ..|...||||||| .   ||.|...|.     .| ||..|||||| ||||..|.
qywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfia

IDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE
...||...|.|. |.....|| |||.| ..|||..||.|...|.||
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 928-1192 6.3e-82 270.3 In-house 18-273 (284) alignment 
Range on Protein: 928-1192
Range on HMM: 18-273/284.0
DVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyrDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTnlvevgRVKCY
  |  |||. |||.|.|.|.|...| |...     |||||| .|       ||||.  |||||||  .|. |||||||. ... ||..|      . || 
tfanldqnkdknrighilafdknvvklerliGeefsdyinasfi......tGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcs

KYWPDDT-EVYGDFKVTCVEMEPLAEYVVRTFTLERRG-YNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKL--SNPPSAGPIVVHCSAGAGRTGCY
.||| .. . .. |||    .|  .||||| . | . |  ..||...|||| ||||.||| ... |. ....|.   |      .||||||||.|||| |
qywplkivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvy

IVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIPVCEFKAaYFDM
||.|..||. ..|  ||.|| |. || .| ..||   || ||. |.||  | | . . . .| | |.. 
ivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpa.ylee
subfamily_CG7180_pd Subfamily CG7180 928-1177 8.1e-66 216.7 In-house 35-294 (296) alignment 
Range on Protein: 928-1177
Range on HMM: 35-294/296.0
DVAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIDiwlyrdGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRvKCY
  . . .|| |||. ... ||. ||.|. .. . .|||||| |.|      .. ..  || |..|..||| .|||....|.. ..|..|.  .  . .. 
agglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvd......sflkkkeyivteapkketvdefWrlvydeeisavvvLtktfdfak.myp

KYWPDD-TEVYGDFKVTCVEMEPLAEYVVRTFTLERR----------GYNEIREVKQFHFTGWPD-HGVPYHATGLLSFIRRVKLS-----NPPSAGPIV
.||| .  | ||.. |  ||.. .|. . ||| | ..             | | ||.|..| |.  . ||. ...|. ..|||.|      . |  ||.|
sywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrlwrekvdedpeegPvv

VHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGE
|..| ||.|.| |. ||. |...|.|. ||... || ||  | ..|.. |.| .| | .||| ||. 
vvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnk
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 929-1171 5e-83 272.9 In-house 2-239 (239) alignment 
Range on Protein: 929-1171
Range on HMM: 2-239/239.0
VAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYK
 |||  |.||||| ||..||||||.|. . .|| ||||||.|.     ||    |  |||||| |  .  |||||.|||. . |||.| |.|  . ||..
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasyl.....rdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchq

YWPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDI
|||| |  | ...||  . | .|.|..||| . . |  | | | |.||| |||.||| .|| .| . |..   . | | | |.||||| ||||...||| 
ywpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvida

MLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE
||  |...  |||.| |||.|  |  |||| |||.||| |.||
mlrqakkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_PTPN23_pd Subfamily PTPN23 929-1172 1.3e-59 196.4 In-house 37-279 (288) alignment 
Range on Protein: 929-1172
Range on HMM: 37-279/288.0
VAKKDQNRAKNRYGNIIAYDHSRVILQpvedDPSSDYINANYIdiwlyRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYK
.|    .  |||. .|. |||.|| |.    .   ||||| ..     .|      ..||||.| ..|. |||.|.....|  |||...  | |. |. .
iaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfv.....kdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdr

YWPD---DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKL----SNPPSAGPIVVHCSAGAGRTG
|||    .|...||..||. . . . ..| |...|| .. .....|.  ..| ||..|||     || |.  |.      . .|  |.||||||| ||||
YwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtg

CYI-VIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEA
 .  |. .. .. ...|..|| . |. ||  | .|||..||. |  .|.|||
vfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 929-1033 1.7e-28 94.4 In-house 41-153 (350) alignment 
Range on Protein: 929-1033
Range on HMM: 41-153/350.0
VAKKDQNRAKNRYGNIIAYDHSRVILQPV--------EDDPSSDYINANYIDIWLYRDgYQRPSH-YIATQGPVHETVYDFWRMIWQEQSACIVMVTNLV
...  .  ||||| ||. |.||||.|.              ..|||||||. .  .    . |.. |||||.|. .|| ||...| . .   |...|..|
lseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsv.einpdfkYiatqaPlpstvddfykvillnkvkvilsltsdv

EVGRVKCYKYWPDD
| .. |||.||.. 
elnlekcyrYWqeg
subfamily_eak_pd Subfamily eak 929-1087 4.1e-16 53.3 In-house 46-197 (332) alignment 
Range on Protein: 929-1087
Range on HMM: 46-197/332.0
VAKKDQNRAKNrYGNIIAYDHSRVILQPVEDDPSsDYINANYIDiwlYRDgyqRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYK
.... ..  .|   .|. ||.  | | .   ..   ||||  ..   . .      .|| |  . .. |. ||.|. ...| .||.. . || .  |  |
etarleavnrn.vvkivpydrylvrltssqlnrl.Gyinaslae...fse...vGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdk

YWPDDT-E--VYGDFKVTCVEMepLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYH
|.||.| |   .| ..|.. |   . . ...|  || .  ||  .|. ... || .  .|  
yfpdktreelkfGildverkef..vkrniletrllelskGnethrvlhykvfGwtettlpky
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 929-1018 1.2e-07 24.8 In-house 21-77 (169) alignment 
Range on Protein: 929-1018
Range on HMM: 21-77/169.0
VAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINAnyidiwlyrdgyqrpshyiatqgpvhetvydfwRMIWQEQSACIVMVTNL
.|.   | .|||    .|  | || || | .| .||||||                                 ||||. ... ||.. . 
maeltcnetknrpagplapshtrvklqrvmedlgsdyina.................................rmiwetnasvivvlgdt
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 929-1018 1.7e-07 24.2 In-house 20-76 (169) alignment 
Range on Protein: 929-1018
Range on HMM: 20-76/169.0
VAKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINAnyidiwlyrdgyqrpshyiatqgpvhetvydfwRMIWQEQSACIVMVTNL
.|.   | .|||    .|  | || || | .| .||||||                                 ||||. ... ||.. . 
maeltcnetknrpagplapshtrvklqrvmedlgsdyina.................................rmiwetnasvivvlGdt
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 930-1172 2.1e-83 274.2 In-house 2-239 (239) alignment 
Range on Protein: 930-1172
Range on HMM: 2-239/239.0
AKKDQNRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKY
|||  |.||||| ||..||||||.|. . .|| ||||||.|.     ||    |  |||||| |  .  |||||.|||. . |||.| |.|  . ||..|
akkrvnkaknryanivtydhsrvvleklsndphsdyinasyl.....rdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqy

WPDDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIM
||| |  | ...||  . | .|.|..||| . . |  | | | |.||| |||.||| .|| .| . |..   . | | | |.||||| ||||...||| |
wpdstskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidam

LDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEA
|  |...  |||.| |||.|  |  |||| |||.||| |.|||
lrqakkqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 930-1173 1.2e-39 130.8 In-house 43-287 (305) alignment 
Range on Protein: 930-1173
Range on HMM: 43-287/305.0
AKKDQNRAKNRYGNIIAYDHSRVILQPVEddpSSDYINANYIDIwlyrdgYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKY
 |. |.. |||| ..   |. || |..       .|| |||.           |  .| || |...|  ||| | .|..   | |. ||.| |  ||..|
fkeaqeagknrykdvgcldnnrvklegpw...pheyihanyvst......ptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcley

WPDDTEVYGDF-----KVTcVEMEPLAE--------YVV--RTFTLERRGyNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKlsnpPSAGPIVVHCS
.. . .   .|     |.. | .|  ..         .|    ...|  | .. | |...|.  ||| |||   . .| .. . .    || ||||||||
faskdkdvlefeekgqkis.vkfessvtlkfrkdakakvtetvlviegpg.ekarkvthyhwidwpdrgvpaadlailellekar....pskgpivvhcs

AGAGRTGCYIVIDIMLDMAE-REGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEAC
|| ||||  .... .||     . . |    .. .| .| | .||..||.|.|. ||. .
agigrtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 930-1015 3e-08 27.6 In-house 32-116 (347) alignment 
Range on Protein: 930-1015
Range on HMM: 32-116/347.0
AKKDQNRAKNRYGNIIAYDHSRVILQPVED-----DPSSDYINANYIDIwlyrDGYQrpSHYIATQGPVHETVYDFWRMIWQEQSACIVMV
.. ... .|||  .    | .||.| | .      |..  |||| .| .    |  .   .|| || |. .|| |||.|.   . . .| .
vewekslsknrskdvklidatrvvlspeksknsraddvetyinashikf....dnas..keyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 931-1173 1.2e-46 154.2 In-house 37-277 (307) alignment 
Range on Protein: 931-1173
Range on HMM: 37-277/307.0
KKDQNRAKNRYGNIIAYDHSRVILQpvEDDPSSDYINANYIDIWLyrdgyqRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYW
  . |  |||| .. . |..|....   |  .|||| |||. | .      .| ..|..||| ..|.|.|| |. ||.  ...|. ...|....|| .||
afsantdknryqdvkcqdkgrivvk..fdglasdyihanylgiai......kpkkficaqgplentqysfwamaiqekvesvimlckvielakikceqyw

PD---DTEVYGDFKVTC-------VEMEPlAEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSnppsAGPIVVHCSAGAGRT
|    .. |.|.   |         .. |  | ..   ||.    .. | .... .. |||.|||    . . ..  |.        |.||||||| ||.
pleegqklvfgeapntisvanlgakklap.dedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavryd....tnpvvvhcsaGvGrs

GCYIVIDIMLD-MAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEAC
|  . | .. | | . .   |. . |. |||.|   .||| ||...|  .||  
GtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 931-1172 1.1e-35 118.1 In-house 39-270 (288) alignment 
Range on Protein: 931-1172
Range on HMM: 39-270/288.0
KKDQNRAKNRYGNIIAYDHSRVILQpveDDPSsDYINANYIDiwlyrdGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYW
.  .| ...|| |.   | .|| |.   |||   ||.|| .         . . . | .| |.. |.  .|.|. ...   |||...|.| |. |  .|.
sfianptrdryenlprcditrvkls...ddpd.fyiaanvvs......sakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyf

PDDTEVYGDFKVTCVEMEPL----AEYVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVklsnPPSAGPIVVHCSAGAGRTGCYIVI
|        ..  |  .          |. .     .  .|   ||. |.  |.|.|||      | .. ..         |||||.|||.||||  |.|
PsklGekarigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlili

DIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEA
 |.|...  .  . | . .. ||  | . .||| ||...|  .|| 
lialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 932-1171 6.1e-41 135.2 In-house 30-257 (267) alignment 
Range on Protein: 932-1171
Range on HMM: 30-257/267.0
KDQNRAKNRYGNIIAYDHSRVILQPVEDDpssdYINANYIdiwlyrDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNlveVGRVKCYKYWP
  .|...||. . . ||..||||.  |..    |||| |.      .||..  ..|.||.|.. |. ||. .| ... . ||..|.   |.  .  ..||
aeknqernrlddnlpyddtrvilrtkeee....yinasyv......egyktknafivtqdplkntitdfltvihdqkvpvivlltk...vftdnirlfwP

DD---TEVYGDFKVTCVEMEPLAEYVVRTFTLerRGYNE-IREVKQFHFTGWPD--HGVPYHaTGLLSFIRRVKLSNppSAGPIVVHCSAGAGRTGCYIV
     .. | |. |     .   .| . |. |  .  ||  ..|  ...  |       ||    |.  . . .| |     |.||.||.| ||.| ..|
Pkmgqakkyqdltvehslekeendyqiitlel..kfknesahnvtlyyykkwnintnnkpyl.kplfgilaknqlen..gnrPlvvacsdGvGrsGtflv

IDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE
|| .|. | .|||.||.. .. .||.|| .|.| |.||.||. . |
idsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 932-1172 6.8e-40 131.6 In-house 52-288 (305) alignment 
Range on Protein: 932-1172
Range on HMM: 52-288/305.0
KDQNRAKNRYGNIIAYDHSRVILQpveDDPSSDYINANYIDIWLYRDgyqrpSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP
 | . .|||| .. . |.| | |.   . . |||| |||.   .  .       .|..|||. .|. .|| |. |..   |||. . ||.|..|| .|||
adiaitknryqdvpcqdqsavkld...kpspsdyihanyvgcpmipe.....krficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywp

DDTEVYGDFKVTCV--------EMEPLAEYVVRTFTLERRGYNEIrEVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNppsaGPIVVHCSAGAGRTGCY
       ..|  .|         ||  ||  . .. |   | ...  |.....| ||| |||      | ..  .. |.     ||||||||| ||||  
aaqgeklelksgivvenvsgskpmerdaeiqitllnltysgdqkm.svrhlqwtewpdrgvppckltslellsairgsk....vpivvhcsagigrtgti

IVIDIMLD-MAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEA
. |. .|. .||   .  . . ||||| .|   .|.. ||.|||  .|. 
vaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 932-1177 1.4e-32 107.8 In-house 32-273 (285) alignment 
Range on Protein: 932-1177
Range on HMM: 32-273/285.0
KDQNRAKNRYGNIIAYDHSRVILQPVEddpsSDYINANyidiWLYRDGYQrPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP
 . |   ||| .. . . .||.|.  .     ||| |.    |.   | .  | ||.||||. ||. |||.||.||. | ..|.  |.| |  ||  |.|
yeanpdlnryadvrcieetrvvlknhd....rdyihas....wmrmpgkd.qstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyyp

DDT-EV--YGDFKVTCVEM--EPLAEYVVRTFTLERRG--YNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPpSAGPIVVHCSAGAGRTGCYI
.   ||  .| ...|  |   | .|  .. ..|.       .|   ... .   |||.  |  |  .. . . ||  ||    ||.|||||| |||  ..
eklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnp.kekpicvhcsagvgrtatfv

VIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEAcLCGE
 ||        .  ... . |. .|. |.. ||.  |..|..  ..|  . ||
gidyatirimenpniemldivremramrfqavqshmqflflyvvlmey.fige
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 933-972 1.8e-06 21.8 In-house 37-75 (244) alignment 
Range on Protein: 933-972
Range on HMM: 37-75/244.0
DQNRAKNRYGNIIAYDHSRVILQPVEDDpSSDYINANYID
  | .|||| ||. .|..||||   . . .|||||||||.
sanatknryinilpfdetrvilssskke.gsdyinanyiq
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 934-1171 9.7e-73 239.3 In-house 2-237 (237) alignment 
Range on Protein: 934-1171
Range on HMM: 2-237/237.0
QNRAKNRYGNIIAYDHSRVILQPVEDDpsSDYINANYIDIWlyrDGyqRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD-
.|..|||||||.|||||||.|.    .  ||||||.|.. .   ||   | .|||.|||.  .  |||.|.|||. . |||.| |.|  ..||.||||. 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgf...dg..tpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpst

-DTEVYGDFKVTCVEMEPLAEYVVRTFTLERRG-YNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNP--PSAGPIVVHCSAGAGRTGCYIVIDI
 . . || . |.    | ...| ||...| .|.  .|.| ..|..|| |||.||| ... || | ...   .|  . .|| ..||||| |||| ..||| 
dqpaaygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvida

MLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE
||  |. . |||||| |...   |  ..||..||.|||..|||
mlrqakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 934-1170 2.7e-70 231.6 In-house 27-265 (274) alignment 
Range on Protein: 934-1170
Range on HMM: 27-265/274.0
QNRAKNRYGNIIAYDHSRVILQP-VEDDPSSDYINANYIdiwlyrDGYQ-RPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP
 .  |||| .|.  ..|||.|..   .|. |.|||||||       ||. .   |.|||||. .|| ||||||.||..  |||.|.| |  . || .|.|
gsqtknryktilPnensrvllesessededssyinanyi......kGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfP

DDTEV-----YGDFKVTCVEMEPLAEYVVRTFTLERRgyNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNP---PSAGPIVVHCSAGAGRTGCY
|....     |||.... ...    .| ||...|.    .. |.|| . .| |||| .| .|. ||.... |. |.      ..|.||||||| |||||.
daedyeiserygdveikvekiverndysvrklvlkyl..erersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcf

IVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAIL
| |.| .   ..|.|||. . |  ||  |  ||||.||| .|| |. 
iaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 934-1174 2e-16 54.5 In-house 46-280 (303) alignment 
Range on Protein: 934-1174
Range on HMM: 46-280/303.0
QNRAKNRYGNIIAYDHSRVILQpvedDpsSDYINANYIDIwlyrdgyQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDD
.|  |||. ..|  |||.| |     |  | || |.|...       .   . | || |.  |  |||.|| ...  |....    |  ..     .| .
knmdknrfvdvicldhskvkls....d..ssyihasylel.......dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn

TEV--YGDFKVTCVE---MEPLAEYVVRTFTLERRGYNEIREVkqFHFTGWPDHGVPYH-ATGLLSFIRRVK--LSNPPSAGPIVVHCSAGAGRTGCYIV
 .   . .  .   |   .|    .|..  ..    |. .  |   |.  ||   .| . .  ..  | ...  | .   . | |    .| ||.| . .
qdflkfeersirvgefkrvelgdgwvlkvlsvsngdyksflhv..hhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfal

IDI-MLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACL
..   | . . .  .|. .|.. .|  |.  ||   |. ...  . |  |
fetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 934-1019 9.8e-09 29.1 In-house 33-111 (332) alignment 
Range on Protein: 934-1019
Range on HMM: 33-111/332.0
QNRAKNRYGNIIAYDHSRVILQPveDDPSSDYINANYIdiwlyrDGYQRPSHYIATQGPVH-ETVYDFWRMIWQEQSACIVMVTNLV
.|   ||   . ..||||| | |  .|   |. ||...      ||| . | || .| |.   | | ||||. . . . |... .. 
nnmdmnriphlycfdhsrvelap..qdgkddfynaswv......dgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdid
Y_phosphatase Protein-tyrosine phosphatase 935-1171 7.2e-89 292.6 Pfam-A 1-235 (235) alignment 
Range on Protein: 935-1171
Range on HMM: 1-235/235.0
NRAKNRYGNIIAYDHSRVILqpvEDDPS-SDYINANYIdiwlyrDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP--
|. |||| .|..||..|| |   ..... ||||||||.      .||......||||||. .|. |||||.|||.. .|||.|.|.| ||.|| .|||  
nkkknRykdilpydktrvkl...kgsegpsdYInAnyv......kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

-DDTEVYGDFKVTCV-EME-PLAEYVVRTFTLERRGYN-EIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVID
 .... |||.||... . .   .||..|...|. .. . | |||||.|.|.||||||| ....||..||.|. |. .. ||.|||||||.||||.....|
eeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvald

IMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE
|.|...|.|. ||....|| ||..|..|||..|||||...||||
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 935-1171 7.2e-89 292.6 In-house 1-235 (235) alignment 
Range on Protein: 935-1171
Range on HMM: 1-235/235.0
NRAKNRYGNIIAYDHSRVILqpvEDDPS-SDYINANYIdiwlyrDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP--
|. |||| .|..||..|| |   ..... ||||||||.      .||......||||||. .|. |||||.|||.. .|||.|.|.| ||.|| .|||  
nkkknRykdilpydktrvkl...kgsegpsdYInAnyv......kgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpee

-DDTEVYGDFKVTCV-EME-PLAEYVVRTFTLERRGYN-EIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVID
 .... |||.||... . .   .||..|...|. .. . | |||||.|.|.||||||| ....||..||.|. |. .. ||.|||||||.||||.....|
eeesltygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvald

IMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE
|.|...|.|. ||....|| ||..|..|||..|||||...||||
illeqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0041856 (Phosphotyrosine protein) phosphatases II 935-1181 3.8e-52 171.8 In-house 1-179 (182) alignment 
Range on Protein: 935-1181
Range on HMM: 1-179/182.0
NRAKNRYGNIIAYDHSRvilqpveddpSSDYINANYIDiwlyrdGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTnlvevgrvkCYKYWPDDT
|. |||| .|. |||||           .||||||...      |.......||||||  .||.||.||.....  .||..|         .. |||.. 
nldknrysdilpydhsr..........dldyInanlyl......gslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell

evygdfkvtcvemeplaeyvvrtftlerrgyneIREVKQFHFTGWPDHGVPYhATGLLSFIRRVKLsnppSAGPIVVHCSAGAGRTGCYIVIDIMLDMae
                                  |.. |.....|||||||     ||.||..|.     . ||..|||||| ||||.......|. .  
.................................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl..

reGvVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLCGETAIP
  | |.....|| .|||| .||.|..||.|...|.|| .|...| ..
..g.vsleeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
subfamily_CG42327_pd Subfamily CG42327 935-1099 8.2e-31 101.8 In-house 28-191 (319) alignment 
Range on Protein: 935-1099
Range on HMM: 28-191/319.0
NRAKNRYGNIIAYDHSRVILQPVEDDPSSDYINANYIdiwlyRDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP---
 . |.|. |..   ..||.|| . ||... |..|.|.     |   . |..|||.| .  ..  ||||..|. ||  || .|.| | |  .| .|.|   
skdksrvinvvPlPetrvvlqrigdddkdeyldasyv.....rGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtke

--DDTEVYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIREVKQFHFtGWPDHGVPYHATGLLSFIRRVK
  |.|..|||..||  . |   .|.. |. | |   .| ||.  . .  |.. .|| . . |.. . .|.
tldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 937-1173 7.8e-25 82.2 In-house 45-276 (312) alignment 
Range on Protein: 937-1173
Range on HMM: 45-276/312.0
AKNRYGNIIAYDHSRVILQPVEDdpssDYINANYIDIwlyrdgYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD----
  ||| ||  .|  |  |   |.     || ||.. |        .| ....||||...|.  ||..     |..|.... .|| |  || ||  |    
dlnrypniqcwdrgrftlagden....fyihanfvki......ctkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgf

----DTEVYGDfkvTCVEMEP--LAE--YVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNppsaGPIVVHCSAGAGRTGCYI
    |  || .    | |.|    .      | . .  .   .   .... .. |||||.|      | ..  ||  .     |.. ||||| ||||  .
vdledhrvyte...ycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkkdk....kpviahcsagvgrtgtla

VIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEAC
.|. |.         .. .    ||  |   |..  ||..   ..||  
liesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvlefl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 938-1180 8.7e-24 79.2 In-house 22-257 (290) alignment 
Range on Protein: 938-1180
Range on HMM: 22-257/290.0
KNRYGNIIAyDHSRVILQPVEDDPSSDYINANYIDiwlYRDGYQrpshYIATQGPVHET-------VYDFWRMIWQEQSACIVMVTNLVEVGRV----KC
..|. . ..  ..||.|.      ..||| ||..    . .| .     |.|| | ...       . .|| |. ||..  .||. .  |  .      |
dqRlevpLv.eatrvvLkgygkrfnddyiHAnrvt...cpnglr....liltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaC

YKYWPDDTE---VYGDFKVTCVEMEPLAEYVVRTFTLERRGYNEIrEVKQFHFTGWPDHGVPYHATGLLSFIRRVKlsnpPSAGPIVVHCSAGAGRTGCY
 || |.  .    .....| | ..|   .  .|. ...  . .|   |.   . || .  |. .   ||| |. ||     |  |..|||  |  |  . 
akYvpesvgeelkfkgltvkCkskekeddvetRelvvkfddeeef.tvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAal

IVIDIMLDMA-EREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILeaclcgetaI
  |..   .  | .| | . . .||||..| ......... |.  .|.         .
aaiilgyQkiaetsgsvkledvlkalrkqralaitsalelafvdagiv.........l
0044763 (Phosphotyrosine protein) phosphatases II 947-1170 5.3e-37 122.5 In-house 2-168 (178) alignment 
Range on Protein: 947-1170
Range on HMM: 2-168/178.0
YDHSRVILQPVEDDPSSDYINANYIDiwlyrdgyqrPSHYIATQGPvhetvYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEvygdfkvtcve
.|..||.|...|. ..||||||..|.          |  |.....|      |........   .||..|. .| |..||..|||....           
ldrtrvllsnleglersdyinaseil..........pglylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...........

meplaeyvvrtftlerrgyneirevKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMaereGVvDIYNCVK
                          |......||||||     .| |.. ..   ... ||..|||||| ||.|. .....|. .    |. .......
.........................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaie

ALRSRRInMVQTEEQYIFIHDAIL
 .|.||  .|....|. ....  |
lvrerRp.ivpnpgqlrqLyefel
0046846 (Phosphotyrosine protein) phosphatases II 953-1170 6.6e-44 145.1 In-house 2-170 (176) alignment 
Range on Protein: 953-1170
Range on HMM: 2-170/176.0
ILQPVEDDPSSDYINANYIDIWLyrdgyqrpshYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEVYGdfkvtcvemeplae
.|..  .|...||||||.|.  .          .||||||...|..||..|.....  ..|..|..|| ||.||. |||. ...                
rlrllgldldldyinanlilgsr..........piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..............

yvvrtftlerrgyneirevkQFHFTGWPDHGVPYHaTGLLSFIRRVKLSNPPSaGPIVVHCSAGAGRTGCYIVIDimldMAEREGVVDIYNCVKALRSRR
                    |.....||||||| . . ||.... ..       ||..|||||| ||||......    . |.|  ........ .|..|
....................qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqR

I-NMVQTEEQYIFIHDAIL
  ..|||.||| |.....|
plgavqtpeQyrflyefel
0043147 (Phosphotyrosine protein) phosphatases II 960-1166 6.2e-43 141.8 In-house 2-154 (172) alignment 
Range on Protein: 960-1166
Range on HMM: 2-154/172.0
DPSSDYINANYIdiwlyrDGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLvevgrvkcykywpddtevygdfkvtcvemeplaeyvvrtft
|..||||||.|.      |.|  | ..||||||  .|. |||||.....  .||..|.|                                         
degsdyinasyl......dlyyipdrfiatqgplrntladfwrmlkelgithivnltel.........................................

lERRGYNEIREVKQFHFTGWPDHGVPyHATGLLSFIRRVKL-SNPPSAGPIVVHCSAGAGRTGCYIVIDIMLdmaereG-VvDIYNCVKALRSRRINMVQ
 .  .... |.. |.....||||||| ..  ||.|.. ..   .  . ||..|||||| ||||. .....||        . .....|. .|..| ..||
.lydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavq

TEEQYIFIH
...||.|..
npsqyrfly
0051429 (Phosphotyrosine protein) phosphatases II 962-1198 1.1e-57 191.0 In-house 3-248 (272) alignment 
Range on Protein: 962-1198
Range on HMM: 3-248/272.0
SSDYINANYIDIWlyrDGYQRPSHYIATQGPVHETVYDFWRMiWQEQSACIVMVTNLVEVGRVKCYKYWP-------------DDTEVYGDFKVTCVEME
 |.||||.... .    .. .|  .....|| . |. ||||. ....  .||......|.||.||..|||             . |  ||.. ||....|
lsgyiNardvggy...grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee

PLAEYVVRTFTLERR-GYNEIREVKQFHFTGWPDHGVPYHAtgLLSFIRRVKLsnppsAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVD-------
 |  |..|...|..  ...|.||| ..|.|.|||||||..|  ||.... .        ||..|||||| .|||........|   ..| .||       
llldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnl

-IYNCVKALRSRRINMVQTEEQYIFIHDAILEAcLCGETAIPVcEFKAAYFDMIRIDSQ
 ....|. ||..| ..|||||||.|...|.||. |.. ..... |. .|..|.|. .  
yleeaveelraqrpgavqteeqylflyeallel.lrsllsvra.eyllaaldaideeyG
0051082 (Phosphotyrosine protein) phosphatases II 962-1170 6.5e-35 115.3 In-house 2-150 (151) alignment 
Range on Protein: 962-1170
Range on HMM: 2-150/151.0
SSDYINANYIDiwlyrdGYqrpshYIATQGPVHetvyDFWRMIWQEQSACIVMVTNLVEVGrvKCYKYWPDDTevygdfkvtcvemeplaeyvvrtftle
 |||||..|..      |.     .....|| .    ||........  .||......| |  .|..|.|.                             
lsdyinfsyvt......gg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg...........................

rrgyneiREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLsnpPSAGPIVVHCSAGAGRTGCYIVIDIMLDMaeregvVDIYNCVKALRSRRINMVQTEEQ
       .||.......|||.|.| .   .|.|.. .     .. ||..|||||| ||||. .....|| .      |... ... .|..| ..||...|
.......ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqq

YIFIHDAIL
..|.. |.|
flfqlfall
0036282 (Phosphotyrosine protein) phosphatases II 963-1167 4.9e-47 155.2 In-house 2-164 (174) alignment 
Range on Protein: 963-1167
Range on HMM: 2-164/174.0
SDYINANYIDIWLYRDgyqrpsHYIATQGPVHetvydFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDdtevygdfkvtcvemeplaeyvvrtftler
||||||...|..   .      ..||.|||       ||.|...... ..||.....| |..||. |||.                              
sdyinaspldlsyitp......rliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................

RGYNEIREVKQFHFTGWPDHGVPYHATgLLSFIRRVKLSNPP-SAGPIVVHCSAGAGRTGCYIVIDIMLDMAErEGVVDIYNCVKALRSRRINMVQTEEQ
. . . |.. |.....|||||||  .. ||.|...|.      . ||..|||||| ||||. .....|| . . |..||... |..||. | .||||..|
lredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YIFIHD
|.|...
yrflyy
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 966-1164 7.9e-29 95.3 In-house 78-272 (301) alignment 
Range on Protein: 966-1164
Range on HMM: 78-272/301.0
INANYIDIWlyrdgyQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTEV---YGDFKVTCVEMEPLAEYVV--RTFTL
| ||.|.         .| ..||||||...| .||| |. | .   |||... ||    || .| | ...     | ||.. ...| . .  .  ||. .
ihanwipts......GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlev

E-RRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNppsaGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTE
|   |  . | |  . .. |.|.|||   . |  ..  || |.     ||||||||| ||. ..|  ...    | .  ... . .| || .| | |||.
edstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkkse....kPivvhcsaGiGrsvafigteylareveadptieltealkhlrehrwngvqtn

EQYIF
.|  .
sqlyw
0049260 (Phosphotyrosine protein) phosphatases II 978-1167 1.2e-40 134.0 In-house 3-144 (152) alignment 
Range on Protein: 978-1167
Range on HMM: 3-144/152.0
DGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWpddtevygdfkvtcvemeplaeyvvrtftlerrgyneirevkQFHFT
||| .| ..||||||  .|. |||||... .  .|||.|.|.| |..||..|.                                          |....
dgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qylhl

GWPDHGVPYHATGLLSFIRRVKLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLdmaereGVVDIYNCVKALRSRRINMVQTEEQYIFIHD
 ||||||| ..  || ... ..  .  . ||..|||||| ||||.......||        |.....|. .|..| ..|....|..|...
pwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 978-1074 1.3e-11 38.5 In-house 230-323 (440) alignment 
Range on Protein: 978-1074
Range on HMM: 230-323/440.0
DGYQRPSHYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEvgrVKCYKYWPDDTE--VYGDFKVTCVEMEPLAEYVVRTftLERRGYNEIREVKQF
.|| .   .|||| |.  || ||||.. . . . |.|. .| .     |  ||| .|    .| | |     | .    |||  || .  .|. |..||
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrt..lelkykeevheirqf
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 985-1166 6.2e-24 79.3 In-house 6-197 (199) alignment 
Range on Protein: 985-1166
Range on HMM: 6-197/199.0
HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD---DTEVYGDFKVTCVEMEPLAEYVVRTFTLER--RGYNEIREVKQFHFTGW
.||||| |..||. |||.|.|.  |  |||| .      .    |||     |  || . ||.  .   ..|.. .. |          ||. .. || |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVPYHAT--GLLSFIRRV-KLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAE--REGVVDIYNCVKALRSRRINMVQTEEQYIFIH
 ..  |  |   |..   | | |  .     |..|||| | | || .. .|| .   |  .  |||...  | ||  |  .. . ..| ||.
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 985-1166 6.4e-24 79.2 In-house 5-196 (198) alignment 
Range on Protein: 985-1166
Range on HMM: 5-196/198.0
HYIATQGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPD---DTEVYGDFKVTCVEMEPLAEYVVRTFTLER--RGYNEIREVKQFHFTGW
.||||| |..||. |||.|.|.  |  |||| .      .    |||     |  || . ||.  .   ..|.. .. |          ||. .. || |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PDHGVPYHAT--GLLSFIRRV-KLSNPPSAGPIVVHCSAGAGRTGCYIVIDIMLDMAE--REGVVDIYNCVKALRSRRINMVQTEEQYIFIH
 ..  |  |   |..   | | |  .     |..|||| | | || .. .|| .   |  .  |||...  | ||  |  .. . ..| ||.
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 988-1171 4.3e-21 70.1 In-house 39-219 (255) alignment 
Range on Protein: 988-1171
Range on HMM: 39-219/255.0
AtqgpvheTVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCVEmePLAEYVVRTFTLERR-G-YNEIREVKQFHFTGWPDH
        ||  |...| | ..  .||.... | |..|| .|.|   |.  .. | .||. .  . |. |.|| ..    |   . ..|| ....||...
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiek

GVPYHATGLLSFIRRVKLSNppsagPIVVHCSAGAGRTGCYIVIDIMLD-----MAERE-GVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILE
  |  |  .|  .. |. |      ..|||||.| ||.  .......       . . | . .|  . .. |||.|   ..|  |  |    .|.
naPelareilnilkvvrdsk.....svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvld
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 990-1169 3.8e-21 69.8 In-house 97-284 (302) alignment 
Range on Protein: 990-1169
Range on HMM: 97-284/302.0
QGPVHETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWPDDTE---VYGDFKVTCVEME-PLAEYV----VRTFTLERRGYNE----IREVKQFHFT
  | ..|.  .| .| | . | .| ....|| .  || .|. |. .    .| . |. |...  |.|.     .. .|.| . ..      . |. ..|.
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

GWPDHGVPYHATGLLSFIRRVKLSNppsaGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAI
.||||| | .|   |  ..  .         ..|||||| ||||  . |   ...  .. | |. . |. .|. |   ||.|.| |..   .
awpdhGapkeaytaldilkfcesyk....knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliylllcv
subfamily_hpo-7_pd Subfamily hpo-7 994-1166 1.2e-16 55.4 In-house 44-220 (263) alignment 
Range on Protein: 994-1166
Range on HMM: 44-220/263.0
HETVYDFWRMIWQEQSACIVMVTNLVEVGRVKCYKYWP---DDTEVYGDFKVTCVEMEPlaEYVVRTFTLERR--GYNEIREVKQFHFTGWPDHGVPYHA
 .|.  |...| | ..  .||...  | |..|| .|.|   |.  .. . .|.. ..    . ...|  |        ....||.. ..||...  |  |
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpela

TGLLSFIRRVKLSNppsagPIVVHCSAGAGRTGCYIVIDIMLD-----MAERE-GVVDIYNCVKALRSRRINMVQTEEQYIFIH
   |  .. .. |      ..|||||.| ||.  . |....       . . . . .|  . .. |||.|   ..|  |  |  
reilnilkvarnsk.....slvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsi
0048076 (Phosphotyrosine protein) phosphatases II 1036-1170 7.1e-27 89.3 In-house 12-140 (145) alignment 
Range on Protein: 1036-1170
Range on HMM: 12-140/145.0
VYGDFKvTCVEMEPLAEYVVRT-FTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSaGPIVVHCSAGAGRTGCYIVIDIMLDmae
 .|..  | ...| |... ..| ..| .  ... |.. |.....|||||||  .  ||.|.. ..   .   ||..|||||| ||||.......||    
ylgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll...

rEGvVDIYNCVKALRSRRINMVQTEEQYIFIHDAIL
 .| |....... .||.| ..|....|..|.....|
.lg.vsleealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 1053-1167 3.8e-26 86.9 In-house 31-139 (144) alignment 
Range on Protein: 1053-1167
Range on HMM: 31-139/144.0
YVVRTFTLERRGYNEIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSaGPIVVHCSAGAGRTGCYIVIDIMLdmaeREGvVDIYNCVKALRSRR
. | ..| |.  . ..||. |.....||||||| ... ||.|.. ..   ... ||..|||||| ||||.......|.    ..| ........ .||||
ttvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrr

INMVQTEEQYIFIHD
 ..|....|..|...
pgavpnpgqlrfLle
0038934 (Phosphotyrosine protein) phosphatases II 1055-1161 1.8e-07 26.5 In-house 60-168 (194) alignment 
Range on Protein: 1055-1161
Range on HMM: 60-168/194.0
VRTFTLERRGYNEIREV---KQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPP-SAGPIVVHCSAGAGRTGCYIVIDIMLDmaEREGVVDIYNCVKALRS
| ..| . | |.  .      ...   .||.|..     ||.|.. |.  .   . | ..||| || ||||. ..  ..     .  . . .. ..  | 
vidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr..lgmsaeeAialfrekRp

RRINMVQTEEQ
  |. ..  |.
gaipnqdylea
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1067-1210 3.4e-31 103.0 In-house 87-231 (440) alignment 
Range on Protein: 1067-1210
Range on HMM: 87-231/440.0
EIREVKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNP-PSAGPIVVHCSAGAGRTGCYIVIDIMLDMAEREGVVDIYNCVKALRSRRINMVQTEEQYIFI
| | .||.|. ||||.|||  |  .| .|. |. |.   . ||..|||||||||||  |..| .|  |.|   .||.. ....|. | .|||| ||| |.
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDAILEACLCGETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQT
|.|.||. |||.| |   .      ..   . .|. | |..||. 
heavlegllcgdtliledditerveqiqwpnphtdksplqqefeg
PTPc_DSPc_SM00012 1071-1171 8.6e-37 120.9 In-house 2-105 (105) alignment 
Range on Protein: 1071-1171
Range on HMM: 2-105/105.0
VKQFHFTGWPDHGVPYHATGLLSFIRRVKLSNPPSA--GPIVVHCSAGAGRTGCYIVIDIMLDMAERE-GVVDIYNCVKALRSRRINMVQTEEQYIFIHD
||..|.||||||||| ... .|...| || ..  |.  .|.|||||||.||||.....||.|.. |.| . |||...||.||..| .||||||||.|...
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AILE
|.||
alle
subfamily_PTPDC1_pd Subfamily PTPDC1 1073-1167 3e-08 28.3 In-house 84-170 (182) alignment 
Range on Protein: 1073-1167
Range on HMM: 84-170/182.0
QFHFTGWPDHGVPYhATGLLSFIRRVKLSNppSAGPIVVHCSAGAGRTGCYIVIDIMLdmAERegvVDIYNCVKALRSRRINMVQTEEQYIFIHD
 ..  ||.|.||.   . .|  .. |. .   . | . ||| || ||||  |   ..   |.|   ..  . .| .||.| . .|| ||  ....
yvynfgwkDygvas.leriLdivkvvafal..qegkvavhChaGlGrtGvliacylvy..akr...ltaekaiklvrskrpksiqtreqvelvke
subfamily_eak_pd Subfamily eak 1092-1174 2.2e-10 34.5 In-house 224-306 (332) alignment 
Range on Protein: 1092-1174
Range on HMM: 224-306/332.0
LSFIRRVKlSNPPSAGPIVvHCSAGAGRTGCYIVIDIMLDMAER--EGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACL
 |.... .   |||  ||.  .. |. |.| ..|||... . .   . .  . . .   .|.||  | .. |. ||....|.  |
sstlkkyi.htppsfapii.qsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll
subfamily_CG42327_pd Subfamily CG42327 1105-1168 4.8e-14 46.7 In-house 246-310 (319) alignment 
Range on Protein: 1105-1168
Range on HMM: 246-310/319.0
SAGPIVVHCSAGAGRTGCYIVIDIMLDMAERE-GVVDIYNCVKALRSRRINMVQTEEQYIFIHDA
| ||.||||| |.||||  |  || .   |     ||| . |  .|  | . |.| ||| ||.  
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1105-1170 5.3e-14 46.7 In-house 261-341 (350) alignment 
Range on Protein: 1105-1170
Range on HMM: 261-341/350.0
SAGPIVVHCSAGAGRTGCYIVIDIMLD-------MAEREGVVD--------IYNCVKALRSRRINMVQTEEQYIFIHDAIL
 . ||.|||||| |||| .. .| .|        . ..   .|        |   |. ||..||.|||. .|.|||..|.|
rsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1106-1173 1.1e-10 35.4 In-house 265-344 (349) alignment 
Range on Protein: 1106-1173
Range on HMM: 265-344/349.0
AGPIVVHCSAGAGRTGCYIVIDIMLD---MAEREGV-V--------DIYNCVKALRSRRINMVQTEEQYIFIHDAILEAC
  ...|||||| |||| .. .|..|.   . ..| . .         |.  |  ||  ||.|||   |.|.|..|.|. .
lstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1109-1174 2.5e-18 60.2 In-house 1-66 (69) alignment 
Range on Protein: 1109-1174
Range on HMM: 1-66/69.0
IVVHCSAGAGRTGCYIVIdiMLDMA--EREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACL
.|||||.|.|||| .| |  |..||    | .|||.| |. .|  |  ||  | .|||||||. ||  
mvvhcssgtgrtgtfiai..mvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1110-1175 1.2e-17 58.0 In-house 1-66 (69) alignment 
Range on Protein: 1110-1175
Range on HMM: 1-66/69.0
VVHCSAGAGRTGCYIVIdiMLDMA--EREGVVDIYNCVKALRSRRINMVQTEEQYIFIHDAILEACLC
|||||.|.|||| .| |  |..||    | .|||.| |. .|  |  ||  |..|.|||||. ||   
vvhcssGtGrtGtfiai..mvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl
0050432 (Phosphotyrosine protein) phosphatases II 1168-1468 1.8e-82 272.5 In-house 7-300 (308) alignment 
Range on Protein: 1168-1468
Range on HMM: 7-300/308.0
AILEACLCGETAIPVCEFKAAYFDMIR-IDSQTNSSHLKDEFQTLNSVTPrlqAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLitidGESSNYINAALM
|.||..|...| |.|. .|  . |... ........ |. ||..|.||.|    ...|.|.||.|.||||..| || |..  .|    .|.|.|||| ..
allelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyv

DSY--RQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLS--QGCPQYWPEE---GMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEgyL
| |  ..| .||.||.||||||.||||.|...... ||||.. .    . |.||||.|   | |.||...|...|. .. |.. | ....||  ...  .
dgyssklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdges..r

MVQQFQYLGWAsHREVPGSKRSFLKLILQVEKWQeeceeGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFC
.|..|.|..|  .  || | ...|... .|.|..     ..| ...|| .| ||.| |.|. ...|...... ||||.|||.||  .|.||. ||||.|.
tvthfhytnWp.dhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylfl

YDVALEYLE
|...||||.
yralleylk
0051299 (Phosphotyrosine protein) phosphatases II 1176-1467 4.8e-80 264.4 In-house 1-286 (288) alignment 
Range on Protein: 1176-1467
Range on HMM: 1-286/288.0
GETAIPVCEFKAAYFDMIridsQTNSSHLKDEFQTLNSVTPRlqaEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAA
|.|.|.| |.  ..  ..    ... . |..||..| |..|     ..|.|.|| |..|||..| || |..  .| ..|| |.|.|||| ..| |... .
gdteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk

FIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLS--QGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNL--TRPQEGYLMVQQFQYLGWA
||.||.||||||.||||.|...... ||||....    . |.||||..|.| ||.|.|...|. .. |.. | ... ||  ..... ...|..|.|..| 
fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp

sHREVPGSKRSFLKLILQVEKWQEeceEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
 .  || | ...|... .| |...    |.| ...|| .| ||.|.|.|. ...|.......|||..|||.||. .|.||. ||||||.|...||||
.dhgvpdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1177-1469 4.3e-77 254.3 In-house 2-292 (298) alignment 
Range on Protein: 1177-1469
Range on HMM: 2-292/298.0
ETAIPVCEFKAAYFDMIRIDSQTNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITID-GESSNYINAALMDSYRQPAAF
.| | . ..|||   .  .. ... . ...|||.||||. ....|  ..|  |.|..|||..|... | .   | ..|  | |.||||. ...|..  ||
nteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnaf

IVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLS-Q-GCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPqeGYLMVQQFQYLGWASHr
|.||.||..||.||||.| ..  ..||||...  . .  ...|||.||  .|| |.|. .|     |.|.| . . . ..   .  .|.|...  |... 
iatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpdk.

EVPGSKRSFLKLILQVEKWQEECeeGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES
 ||  ..| |.|. .|...|...  |.   |..| .| |||| |.||  |.| ||...|||||..||.||...|..|.. ||| |.|.. ||.|.|
gvpenatsvldllrkvrasqqqa..gnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealds
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1177-1465 5.9e-55 181.8 In-house 8-289 (319) alignment 
Range on Protein: 1177-1465
Range on HMM: 8-289/319.0
ETAIPVCEFKAAYFDM-IRIDSQTNSSHLKDEFQTLNSVTPRLqaEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAA
|. . | .|.| | .. .. | . . ..|. ||. .  ... |   | . | |..| ||||....|. |.    |  ..| | |.||||. .. |...  
esdvavpdfpayyqqlsnksdfdddltklevefrracklgvnl..adqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdk

FIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNevdlSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRpQEGYLMVQQFQYLGWASHrE
.| .| ||.||..||||....| |..||.|      . | |||| ..  ...  .|.  |     . . | ... . .. ...   ..|| .|||  .  
yiaaqGPldntladfWrmiweyncstivllt....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgk.ekdirkitqfhflGwpdv.G

VPGSKRSFLKLILQVEKWQEEcEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE
|| .   ...|. .|.. ..  |...   ..||  | ||.|.. .. ......|... |||.. |. ||. ....|.   || |.|   ||
vpdypsdlmrlvkkvrhltsk.enhranivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
0043336 (Phosphotyrosine protein) phosphatases II 1181-1467 1.7e-71 236.2 In-house 3-277 (278) alignment 
Range on Protein: 1181-1467
Range on HMM: 3-277/278.0
PVCEFKAAYFDMIRIDSQTnsshLKDEFQTLNSVTPrlqaEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGE-SSNYINAALMDSYRQPAAFIVTQ
.|...  |. .. . . ..    |. ||..|.|...    ...|||.|| |.||||..| || |...  |  ..|. .|.|||| ..| |..| .||.||
svkdllkallelllnlktl....lllefeellsfkl....dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatq

YPLPNTVKDFWRLVYDYGCTSIVMLNEVDLS--QGCPQYWPeEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEgyLMVQQFQYLGWAsHREVPG
.|||.||.||||.|...|.|.||||.| .    ..| |||| .|.|.||...|.....  . |.. | ... ||  ...  ..|....||||  . .|| 
gPlpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtnlgdges..rtvthyhylgwp.dhgvpe

SKRSFLKLILQVEKWQEeceEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
|  ..|... .| ...|     .| ...|| .| ||.|.|.|. ...|....   ||...|||.||. .|..|. |.||||.|...||||
slsllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 1190-1467 2.2e-71 236.4 In-house 15-304 (307) alignment 
Range on Protein: 1190-1467
Range on HMM: 15-304/307.0
FDMIRIDSQTNSSHLKDEFQTLNSVTPRLqAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG--ESSNYINAALM--------DSYRQPAAFIVTQ
  ..... ... ..|. ||..|.|||..|   ..||| || |.||||..| || |..   | ..||  |.|.||||  .        |.|... .||.||
lllvllllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIatq

YPLPNTVKDFWRLVYDYGCTSIVMLNEVD--LSQGCPQYWPEE-GMLRYGPIQVECMSCSMDCDVINRIFRICNLtRPQEGYLMVQQFQYLGWAsHREVP
.|||.||.||||.....|.| ||||.| .   .. |.||||.| . | ||...|...| . . ... | ... .| .. .  ..|..|.|.||  .  ||
gPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwp.dhgvp

GSKRSFLKLILQVEKWQEECeEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNV---VDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
 |  ..|..| .|.|..||.  ..|....||  | ||.|.|.|. .. ........   ||...|||.||. .|..|. ||||||.|...||.|
psfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1190-1466 1.4e-37 124.1 In-house 16-276 (287) alignment 
Range on Protein: 1190-1466
Range on HMM: 16-276/287.0
FDMIRIDSQTNSSHLKDEFQTLNsvtprlqaedcsiaclprnHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDF
.| .. ||.. .  .|   .. .                     |||. |.|| |    .| .     |.||||  . ||..  |||..| |.. ||.||
vdalkedsesstatfkaaeelaa...................vkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdf

WRLVYDYGCTSIVML-NEVD-LSQGCPQYWPEE-GMLRYGPIQVECMSCS-MDCDVINRIFRICNLTRPQegYLMVQQFQYLGWaSHREVPGSKRSFLKL
||.|..   .|....  ||.   . | .||||    .| |   |  .. . .. .   | .|. .|   .    .|.|...| |   . .. .  .....
wravletrsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletre..arvvkqldllsw.PdkvlaPtavglirf

ILQVEKWQEECEEG--EGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEY
.|.|..  |   ..   |  ..|.  | ||||.. |. ..|.. .    |||  .|  ||. .  .| |. |.|. |.    |
vldvkqhielardasevGPlvvhddvGiGrsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1191-1469 2.5e-56 185.8 In-house 9-280 (287) alignment 
Range on Protein: 1191-1469
Range on HMM: 9-280/287.0
DMIRIDSQTNSSHLKDEFQTLNSVTPRLQaeDCSIACLPRNHDKNRFMDMLPPDRclpFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFW
.... . ....   |. |..|..|| | .  .  ..  ..|.||||. ..|.||    . . . ||  .||||. .|.|..  |||... |. ||...||
efvakghakgnegfknqftvleqvtqred..evthniasqnkdknRltqilvpdn...yrvllkgehpdyinavfidgykekkafiiaesPmfntarnfW

RLVYDYGCTSIVMLNE--VDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEgYLMVQQFQYLGWASHREVPGSKRSFLKLilq
.|. |   | |||| .   .  . | ||||||  . .|. ..| ..  .  ..|.| ... | .. ..  ..|.|.|.  | |...|.  . ..| .   
kliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagd.kqqvkqyqitnWdstgkvtepqtillvi...

VEKWQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES
 |. ...  .|..  ..|| .. |||.||||. . .. .|.. |.|||  .|  |  ||..| . |||.| .|. ||||.|
eemyktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1191-1469 2.2e-52 172.7 In-house 9-285 (290) alignment 
Range on Protein: 1191-1469
Range on HMM: 9-285/290.0
DMIRIDSQTNSSHLKDEFQTLNSVTprlQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGE---SSNYINAALMDSYRQPAAFIVTQYPLPNTVK
...  . ... .  ...|..|.|     . .   ..  . |. .||| .....|     |  | |.   . .||||. .. |..  ..|.|| |..||..
efvanghakgnegfrnqfkmldsge...sehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlv

DFWRLVYDYGCTSIVMLNEVDLSQ--GCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPqEGYLMVQQFQYLGWASHREVPGSKRSfLKL
|||.|...  .| |||| ..  ..   | ||||...  .||..... .. ..  . |.| ... | .   .   .|.|.|   | |. .|.  . . | .
dFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpqti.llv

ILQVEKwqEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES
| ...|   .  .|..  ..|| .. |||..|||. . .. .| . |.|||. .|..|  ||..|.. .||.. ... |.||.|
ieemyk..tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
0049772 (Phosphotyrosine protein) phosphatases II 1191-1468 6.4e-36 120.1 In-house 5-281 (314) alignment 
Range on Protein: 1191-1468
Range on HMM: 5-281/314.0
DMIRIDSQTNSSHLKDEFQTLNSVTPRLQAED-CSIACLPRNHDKNRFMDMLPPDrCLPFLITIDGESSNYINAALMDSYrqpAAFIVTQYPLPNTVKDF
.... . ..... | .....||......  |  . .| |..|.||||..| || | .. .| . ....|.||||  .|..    .||.||.||..|| ||
plasfsellihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvvdf

----------WRLV--YDYGCTSIVM---------------------LNEVDLSQgcpqywpeegmlrygpiqveCMSCSMDCDVINrifriCNLTRPQE
          ||.|  .|. .  |||                     |...|  .                    .. . .| . ..       |. |. 
reepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng....................neptaadlellk.....eelydpel

GYLMVQQFQYLGWAShREVPgSKRSFLKLILQVEKWqeeceEGEGRTIIHCLNGGGRSGMFCAIGIvveMVKRQNVvDVFHAVKTLRNSKP-----NMVE
   .. .. .. .    ..| . . |....  .|..     . .|....||  | ||.| |.....   ..|...| ..  |.. .|.  |     ...|
ferlgikylripvpD.gsap.lledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaay...lmkllgv.sleealedvrlkRpinpnpgfie

APEQYRFCYDVALEYLE
 .||| |.... ||||.
qleqyefilealleylk
subfamily_PTPRA_pd Subfamily PTPRA 1192-1466 7.5e-59 194.2 In-house 22-294 (330) alignment 
Range on Protein: 1192-1466
Range on HMM: 22-294/330.0
MIRIDSQTNSSHLKDEFQTLNSVtpRLQAeDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGE-SSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFW
 ||| |  .. ....||..| .   ..||  . .|    |..|||....|| |    .| ...|. .|.||||. .| |..   || .| |. .||.|||
eirirsaddnklfreefnalPag..piqa.tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfw

RLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQ--EGYLMVQQFQYLGWASHrEVPGSKRSFLKLI
|.....  ..|||| |..    . | ||||.||.. || |.||   . .  |.  | | . .|.  .  .   .|.|| . .|     ||   .  |||.
rmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv.GvPfepiGmlkll

LQVEKWQEECEEgegRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEY
 .|.| ..   .     ..||  | ||.| |...  |.|.|| ...||||..|| ||. .|.|| . ||| |.| | |||
kkvkklnqqsag...pivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
subfamily_PTPRB_pd Subfamily PTPRB 1192-1468 2.1e-51 169.7 In-house 15-286 (293) alignment 
Range on Protein: 1192-1468
Range on HMM: 15-286/293.0
MIRIDSQTNSSHLKDEFQTLNSVTprlQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFW
 ..  .. .  ....|...|..|    . . ...| |..|..|||. ..|| |     | .... ..|.||||  .. |..|  ||.|| |||.||.|||
hvkkmkadsdlrfseeyeelkavg...kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfW

RLVYDYGCTSIVMLNEVDL--SQGCPQYWPEE-GMLRYGPIQVECMSCSMDCDVINRIFRICNltrpQEGYLMVQQFQYLGWASHrEVPGSKRSFLKLIL
|.|..  .. |||| ..     . | .|||..     || |.|. .. .   | . | ..|..    ..    |.|.... |. | .|| . ...|... 
rmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdh.gvPektktlldfvr

QVEKWQEECEEgEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE
.|....|. .. .. ...||  | ||.| | |.  ... ......||.|  |  ||... ..| . .|| | ... |..|.
tvreaiektas.krPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldllr
0036941 (Phosphotyrosine protein) phosphatases II 1193-1467 9e-76 250.3 In-house 4-277 (297) alignment 
Range on Protein: 1193-1467
Range on HMM: 4-277/297.0
IRIDSQTNSSHLKDEFQTLnsvTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLitiDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRL
...........|. ||..|   .|.|   ..|.|.||.| .|||..| || |..   |   |.|.|.|||| ..| |... .||.||.|||||| ||||.
kllekllflalllkefeel...lpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrm

VYDYGCTSIVMLNEVDLS--QGCPQYWPEE--GMLRYGPIQVECMSCSM--DCDVINRIFRICNLtrPQEGYLMVQQFQYLGWASHrEVPGSKRSFLKLI
|.....|.||||.|..    . |.||||.|  . | ||...|...|..   . |.. | ... ..    .  ..|..|.|.||  |  || | .|.|..|
vweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdh.gvpespaslldfi

LQVEKWQEECEEGeGRTIIHCLNGGGRSGMFCAIGIVVEMVK---RQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
 .|.|....  .| |....|| .| ||||.|.|. .......   ... ||.. |||.||. .|..|. .|||||.|.. ||.|
elvrkvlkllpsg.gpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallell
0047943 (Phosphotyrosine protein) phosphatases II 1193-1467 4.7e-75 247.9 In-house 3-272 (273) alignment 
Range on Protein: 1193-1467
Range on HMM: 3-272/273.0
IRIDSQTNSSHLKDEFQTLNSVTPrlqAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLitiDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRL
.......... |. ||..| |..|     ..|.|.||.|.||||..| || |..  .|   ....|.|||| ..| |... .||.||.||||||.||||.
lllekllgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrm

VYDYGCTSIVMLNEVDLS--QGCPQYWPEEG---MLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQegYLMVQQFQYLGWAsHREVPGSKRSFLKLIL
|...... ||||.|..    . |.||||.||   .|.||...|...|.  . |.. | ... ||  ..  ...|..|.|.||     || |  |.|..| 
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvthfhytgwp.dhgvppslesllefie

QVEKWQEECEEGeGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
.|.|..|.. .. | ...|| .| ||.|.|.|. ........ . |||. ||| ||. .|.||. ||||||.|...||||
lvrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
0039614 (Phosphotyrosine protein) phosphatases II 1193-1467 6.6e-74 244.3 In-house 23-289 (297) alignment 
Range on Protein: 1193-1467
Range on HMM: 23-289/297.0
IRIDSQTNSSHLKDEFQTLNSVTPrlqaeDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG--ESSNYINAALMDSYRQ-PAAFIVTQYPLPNTVKDF
.... ......|. ||..| |..|     |.||| || | ||||..| || |..   | ..||  ..|.|||| ..| |.. . .||.||.|||.||.||
lllekansktllllefeellslkp.....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedF

WRLVYDYGCTSIVMLNEVDLSQ-GCPQYWPEEGMlRYGPIQVECMSCSMDCDVINRIFRICNltrpQ--EgyLMVQQFQYLGWAsHREVPGSKRSFLKLI
||.|...|.|.||||.. .  .  |.|||||||  .||...|..... .. ... | ... |       .  ..|..|||.||  .  || | ...|...
wrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....nges..rtvthfqytgwp.dhgvppslelllefl

LQVEKWQEECeEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
 .|.....|. ...|....|| .| ||.|.|.|. ...|....   |||..|||.||. .|..|. |.||||.||..||.|
elvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallell
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1193-1465 6.1e-60 197.7 In-house 12-277 (288) alignment 
Range on Protein: 1193-1465
Range on HMM: 12-277/288.0
IRIDSQTNSSHLKDEFQTLNSVTprlQAEDCSIACLPRNHDKNRFMDMLPPDrCLPFLITI--DGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFW
. . |..| . ...|...| ..    . .. ... |..|..|||. ..|| |   .  ..   ......||||. .|....  ..| || ||..||.|||
vakksarnrtgfseeynsLaale...ktksvtagrlavnakknRyrnilpyD.ekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfW

RLVYDYGCTSIVMLNEV--DLSQGCPQYWPEEGM-LRYGPIQVECMSCSMDCDVINRIFRICnltrPQEGYLMVQQFQYLGWASHReVPGSKRSFLKLIL
.|||..  . ||||.|.  .  . | .|||...   .|| ..|. ..     |...| . .      ... | ..|.|||.|. |  || ||. .|.|. 
elvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhg.vPeskapllellr

QVEKWQEECeegEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE
||.  ...     |. |.|| .| ||.| | |.  ....|......||. .|. ||......|.  .|| |.|.| |.
qvkvanqad...tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_PTPN3_pd Subfamily PTPN3 1193-1464 8.9e-44 144.5 In-house 6-272 (280) alignment 
Range on Protein: 1193-1464
Range on HMM: 6-272/280.0
IRIDSQTNSSHLKDEFQTLNSVTPRLQaedCSIACLPRNHDKNRFMDMLPPDRCLpflITIDGESSNYINAALMD----SYRQPAAFIVTQYPLPNTVKD
...  . .| ..  .|..|    | |.   .|.| .|.| .|||. |.|| |      .... ....||||  ..    |  .   .|.|| ||..|..|
lllkeglesGavlaqfeqlyrkkpgla...isaarkpenlsknryrdilpydatr...vklkesetdyinanyvnmeipstglvnryiatqGPlaktatd

FWRLVYDYGCTSIVMLNEVD--LSQGCPQYWPEE-GMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEgyLMVQQFQYLGWASHrEVPGSKRSFLKL
||..|..  .. |||| ..     . | |||||.   |.|| ..|.| ... .  .. | . ... .  .|   .. |.||| |. | .|| .. .||..
fWqmvweqksslivmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdketkee..rkilqlqylaWpdh.gvPddsadflef

ILQVEKWQEECEEgegRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVAL
. .|.| ..  ||    ...||  | ||.|.. .. . . .. ... | . . |.|.|. . ..|....||.|  .  |
vervrklrsgkee...PvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1195-1469 8.7e-63 207.3 In-house 16-285 (319) alignment 
Range on Protein: 1195-1469
Range on HMM: 16-285/319.0
IDSQTNSSHLKDEFQTLNSVTPRlqaeDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLV
.  .| .  |. ||..|.  ..     . . |  ..|..|||. ..|. ||.   | ..|| |.|.||||. .|.|..  .|| || || ||..||||.|
alastgetllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmv

YDYGCTSIVMLNEVD--LSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGyLMVQQFQYLGWASHrEVPGSKRSFLKLILQVEK
.....  .|||...   |   . .||||| . .|| . |.  .     |.| | . . ...   |   .|..|||. |. | .|| . .| |.|. ...|
WeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevet.RevkhfqyteWpdh.dvPekatslldllkrirk

WQEECEegEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES
 .|. .  .|  ..|| .| || | |... ...| ||...|.|||. |..||  .. ||. ||||.|.|.. ||..|.
srektq..sgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_PTPN13_pd Subfamily PTPN13 1195-1468 7.8e-39 128.6 In-house 4-270 (273) alignment 
Range on Protein: 1195-1468
Range on HMM: 4-270/273.0
IDSQTNSSHLKDEFQTLNSVTPRLQaedCSIACLPRNHDKNRFMDMLPPDRCLpflITIDGESSnYINAALMDSY--RQPAAFIVTQYPLPNTVKDFWRL
. .. .. . ..||..|. . | ..   |...   .|.||||. ..|| |.     .....|.. ||||.|.      .   .|..| |||.||||||..
lqkkldqqqPaeefkelrelkpldt...cevgkkkenkdknryrnvlPydetr...vklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqm

VYDYGCTSIVMLN-EVDLS-QGCPQYWPEEG---MLRYGPIQVECMSCSMDCDVINRIFRICNLTRpqEGYLMVQQFQYLGWASHrEVPGSKRSFLKLIL
|..  .. |.|.  |..     | .||||.    .  .. ..|| .      .   | . . ..    .    |.....  |  | .|| |  ..|... 
vweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses..gesrevahlnfvkwPdh.gvPssaaellqfva

QVEKWQEeceeGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE
.| . |.     .|  ..||  | ||||.. .| .|.....|.. .|| . |..||. .  .| . .|| |.| ..|| |.
evrrlqt....dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPN6_pd Subfamily PTPN6 1196-1469 1.5e-44 147.3 In-house 20-299 (306) alignment 
Range on Protein: 1196-1469
Range on HMM: 20-299/306.0
DSQTNSSHLKDEFQTLNSVTPRlQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMD--SYRQPAAFIVTQYPLPNTVKDFWRLV
..... . ...||..|.    . .  . . .  |.|. |||.  .|| |     |   .   |.||||  ..  .  . ...| ||  |..||.||||.|
eeslekagfeeefeelqqeeak.kllsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmv

YDYGCTSIVML-NEVDL-SQGCPQYWPEEGML-RYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYlMVQQFQYLGWASHrEVPGSKRSFLKLILQVE
..  .. |||. .||.   . | .|||.| .  .|| |.|...| .   | | | ..... .. .|    | |...  |  |  || ..  .|... .|.
wqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeer.evfqyhfksWPdh.gvpkdpgavLdfledvn

KWQEECE-EGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNV---VDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES
. |||.| . .| ...|| .| || | |  | |........ .   .|. ..||..|. .  .|   .||.| | .  .|.|.
rkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyiet
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1196-1468 3.2e-44 146.1 In-house 9-277 (281) alignment 
Range on Protein: 1196-1468
Range on HMM: 9-277/281.0
DSQTNSSHLKDEFQTLNSVTPRLQAEdcsIACLPRNHDKNRFMDMLPPDRCLPFLIT-IDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVY
 || ... .. |...|...  .  |.    .  . |  |||....   |     .    . ....||||  ...|......|.|| |.|.....||..|.
lsqndnaGfieeyeklaaigvdntat...askadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvw

DYGCTSIVML-NEVDLSQ-GCPQYWPEEG-MLRYGPIQVECMSCSMDCDVINRIFRIcnlTRPQEGYLMVQQFQYLGWASHrEVPGSKRSFLKLILQVEK
..  . |||. .|.. ..  | .|||..   |.|| ..|. .. ..    |.| |..   .| .     |.|..|. |  |  || . . .|.   .|.|
eqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkl...eresgetreveqlaytaWPdh.GvPattkellefrkevlk

WQEECEEgeGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQ-NVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE
 .|. ..     .|||  | ||.| . |.  .|. |... . .||   |. ||...  || .  ||.| | . |..|.
ltekktk..aplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_PTPN12_pd Subfamily PTPN12 1197-1468 2.9e-49 162.5 In-house 3-278 (290) alignment 
Range on Protein: 1197-1468
Range on HMM: 3-278/290.0
SQTNSSHLKDEFQTLNSVTPRLQAED---CSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGES-SNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRL
..... ... |||.| ... ...||.    . .  ..|  |||. |.|| |     | .|..|  |.|||| ..    .. ..| .| |||.|..||||.
ekegeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrm

VYDYGCTSIVML-NEVDLSQ-GCPQYWPEE--GMLRYGPIQVECMSCSM-DCDVINRIFRIcnlTRpQEGYLMVQQFQYLGWASHrEVPGSKRSFLKLIL
....  . .||. .||.| .  | .|||||    |..|...|....  . | | . | ...   .. |.   .|.||.|  |  | .|| |. | |.|| 
iweknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkv...ea.qkesrkvyqfhYtaWPDh.gvPssaksllelie

QVEKWQEeceEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNV---VDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE
.|.. ||   . .   ..||  | || |  .|| .| |..|....   .|||. | .||. .. .| . |||.. |   .|...
lvrelqe...sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvq
subfamily_Ptp69D_pd Subfamily Ptp69D 1198-1467 8.6e-55 181.0 In-house 19-286 (307) alignment 
Range on Protein: 1198-1467
Range on HMM: 19-286/307.0
QTNSSHLKdEFQTLNSVtprLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDY
.|.   .| |...|..        .....    |  |||. |. . |.    | .| | |.|.||||  . .|..   ||. | |. .|..||||.. . 
dtdfglak.eyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeq

GCTSIVMLNEV-DLSQ-GCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRP---QEGYLMVQQFQYLGWAsHREVPGSKRSFLKLILQVEK
  | |||| .. . ..  |..|||.|   .|| | |...| .   | |.| . . .        |    | |..|.||    .|| . |. |||| ||..
evtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWk.DskvPevargllklieqvre

WQEECeegEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
 ..     ..  ..|| .| ||||.| |. .... .|  . ||.|. || ||. .. .|.  ||| |.|   |.| 
lykln...rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1198-1467 2e-17 57.6 In-house 22-285 (302) alignment 
Range on Protein: 1198-1467
Range on HMM: 22-285/302.0
QTNSSHLKDEFQTLNSVtpRLQAEDCSIacLPRNHDKNRFMDMLPPDRClpfLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTV---KDFWRLVY
. .....|.||......  . ..| |..    .| .||.  |.  .|     |. ...|  .|.||. ..        |..| |  ...    .|||.|.
sldtaevkkefkkidtm..kvdlekCka..fkknlkknqsedvpildsn...lvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvf

DYGCTSIVM-LNEVDLSQGCPQYWP--EEGMLRYGPIQVECMSCSMDCDVInRIFRICNLTRPQEGYLMVQQFQYLGWAShREVPGSKRSFLKLILQVek
.  ..|.|. . | .|..   ...|   .  . || . |     .   .     . |  |       ....      | .  .|| .  .  | . .|  
qekivsvvilvgeeelkktlselfpkksgdykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkq.kkvpvkyaeliktaakv..

wQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
  .. .... .|.|   || || |.| .  ..|| ..... . .   ||..|. .|..|.. .|| . | ..| |.
.fakkikadentvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1198-1322 4.5e-17 56.5 In-house 16-147 (392) alignment 
Range on Protein: 1198-1322
Range on HMM: 16-147/392.0
QTNSSHLKDEFQTLnsvtPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITI-DGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDY
.  |. . .||. |    |  .. . ..|  . |  |||. ..|| |.    |  | |   |.|.||. ..|. .  |.| .| | . ...||||.|.. 
nrhsalffeefhdl....pgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqe

GCTSIVMLNE------VDLSQGCPQY----WPEEGM
  |.|.|...       |  . . |.    ||....
nvttiamvtklkegdkgddartvaqfhftewPdkdv
subfamily_CG7180_pd Subfamily CG7180 1199-1466 3.8e-70 230.9 In-house 10-289 (296) alignment 
Range on Protein: 1199-1466
Range on HMM: 10-289/296.0
TNSSHLKDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGES-SNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYG
..  . . |.. .  .||||. .||  .    | .|||  ...|.|   ..| ..|||. |.||||. .||. .....|||. |  .||..||||||| .
dkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydee

CTSIVMLN-EVDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNL--------TRPQEGYLMVQQFQYLGWASHREVPGSKRSFLKLILQ
. ..|.|  . | .. .|.|||.... .||.| || ..     ..  | |..           .  .    .|..||.  | .. .|| |  ....|. .
isavvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrr

VEKWQEEC--EEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEY
|..|.|.   .. || ..... .|..|||...|| . .|.|.... ||||.||||||.|.|..||  |.|...||| ||.
vrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1199-1469 2.2e-54 179.7 In-house 19-285 (305) alignment 
Range on Protein: 1199-1469
Range on HMM: 19-285/305.0
TNSSHLKDEFQTLNSvtpRlqAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGES-SNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYG
.... |. ....| .   .   | . . .   |. |||. .. . |     | . . .  |.||||. .|.|..  ..||.| ||.|||.|||||.... 
ysdkgleaqykslye...e..eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveek

CTSIVMLNEV--DLSQGCPQYWPEEGML--RYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGyLMVQQFQYLGWASHrEVPGSKRSFLKLILQVEKWQ
 ..|||| ..  .  . | |||||.     ..|...||  | .   | |.| ..|..    .|.   | |.|   |  |  || .  |.|.|| .|.| |
vstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkes.rtvlqyqltdWPdh.Gvpqfatsllslikrvqkdq

EEceEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES
..  . .   ..|| .| ||.|.|.|. | .| .|. .|||||. .|.||.....||.  .|| |..|.  |....
kk..dkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_PTPN23_pd Subfamily PTPN23 1199-1467 1.3e-44 147.1 In-house 12-280 (288) alignment 
Range on Protein: 1199-1467
Range on HMM: 12-280/288.0
TNSSHLKDEFQTLNSVTPRLqAEDCSIACLPRNHDKNRFMDMLPPDRCLpflITIDGESSNYINAALMDSYRQ-PAAFIVTQYPLPNTVKDFWRLVYDYG
 . ..|. .|. |..   .  |.. |||   .. .|||. |.|| |.     ....|.  .||||. . .       ||.|| ||..|. |||..||.  
dgktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnR...vklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqk

CTSIVMLN-EVDLSQG-CPQYWPEE--GMLRYGPIQVECMSCSMDCDVINRIFRICnlTRPQEGYLMVQQFQYLGWASHrEVPGSKRSFLKLILQVEK-W
   ||||  . .| .  . .||||.     ..|...| . |      ...|....   |....   .|.  |.  |...  || |  ..|... .||. .
ssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkle..tldadavksvshlqltsWpel.GvPasPetllqfldevesay

QEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVE-MVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
... .. .   ..||. | ||.|.|. .  .|. . |.. ..|. . |..||. . .||.  ||..|.|.. ||. 
eavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaa
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1199-1468 6.6e-41 134.9 In-house 12-294 (301) alignment 
Range on Protein: 1199-1468
Range on HMM: 12-294/301.0
TNSSHLKDEFQTLNSVTPrlqaEDCSIACLPRNHDKNRFMDMLPPDRC---LPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYD
..| ........|.....    . |.. .  .|.  ||| .. . |     |    ..|  . .||||  .|.|..  .||..| |. .|..|||||...
khsnkfeeqykelkeged....ksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwq

YGCTSIVMLNEVDL--SQGCPQYWPEEGML--RYGPIQVECMSCSMDCDVIN--------------RIFRICNLTRPQeGYLMVQQFQYLGWASHREVPg
.  .||||. . .    . | ||||.  .   ..||..|. ..  .  | .               .| |  . .. .     | |.|   |  .  |. 
ekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdk.sswdvlqlqvtdWpqdGvvr.

SKRSFLKLILQVEKWQEECeeGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE
 .|  |. | .| . |     | |  ..|| .. .|||..|.. | .| .|.. |||||  .|..| ||| .|   ||| . |||  .||.
eprtvLqviddvihrqqki..gggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_PTPRN_pd Subfamily PTPRN 1199-1463 2e-38 126.8 In-house 26-288 (297) alignment 
Range on Protein: 1199-1463
Range on HMM: 26-288/297.0
TNSSHLKDEFQTLNSVTPrlQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFL-ITIDGESSNYINAA-LMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDY
.| ..|. |...| .     . . ...|  ..| .|||  ..|| |     |  . . |.|.||||. ..|.  . .|.| || ||..|| |||..|.. 
knkdrlekewealcayea..epstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweq

GCTSIVMLNEVDL--SQGCPQYWPEEGMLRYGPIQVECMSCSMDC-DVINRIFRICNLTRPQEgyLMVQQFQYLGWAsHREVPGSKRSFLKLILQVEKwq
|.. ||.| ...    . | .|||.||   |.  .|. .|  . | | . | | . ||   .     | || .| |  ...|| | .|.|..  .|.|  
GvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtset..rtvtqfhflswp.eegvPasaksllefrrkvnk..

eeCEEGE-GRTIIHCLNGGGRSGMFCAIGIVVE-MVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVA
  .  |     ..|| .| ||.|....| .|.. ..|  . .|.  ... ||. .|..|.. .|..|.. . 
..syrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1199-1466 1.8e-25 84.2 In-house 24-282 (290) alignment 
Range on Protein: 1199-1466
Range on HMM: 24-282/290.0
TNSSHLKDEFqtLNSVTPRLQAEDCSIACLPRNH--DKNRFMDMLPPDRCLpfLITIDGESSNYINAALMDSYRqpAAFIVTQYPLPNTVKDFWRLVYDY
 |   |  |.  |. . | | ..      . .|    |||. |.   |.    .|  ||   .|. |  ..  .  | ||.|| .| .|| |.||.| . 
knvdelakey..leklkpylpvqylerkifdkntefkknrykdvvcndktr..vilkdGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqe

GCTSIVMLNEV--DLSQGCPQYWPEE--GMLRYGPIQVECM-SCSMDCDVINRIFRICNLTRPQEGYLmvQQFQYLGWAsHREVPGSKRSFLKLILQVEK
. . |||| |.  |    | ||.||.   .| .| | | |  . . | ..| ... . .    .|  |  . ..   |   . |. |. ..|...  . |
kvaaivmlceliedGkakceqyypekeGevltfGeitvlcseeddkdaniikktlsvrdkdsGkehkl..khlkikswp.dksvalstlallrtlrilrk

WqeeceegEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEY
         |  ..||  | ||.| | || . ....     .|.   |..||||. | |.   ||    .. |..
a.......sGpvvvhcsaGiGrtGtfvaievglqilldGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_PTPRG_pd Subfamily PTPRG 1200-1469 7.9e-53 174.5 In-house 17-289 (563) alignment 
Range on Protein: 1200-1469
Range on HMM: 17-289/563.0
NSSHLKDEFQTLNSVTPRlQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSN--YINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYG
.   .. ||. |.| |   .  |.. .  | |. ||| ..... ||    |  . |. ..  ||||  .| |..  |||.||.||..|..||||....  
gdigfseefealqsetis.kdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqn

CTSIVMLNE--VDLSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNL--TRPQE--GYLMVQQFQYLGWASHrEVPGSKRSFLKLILQVek
 . |||. .   .  . |..|||... ..|| .||  ..  . .    | . | ||   . ..    ..|.|..|  |  |  || ..   |. . .   
vaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdh.gvPehslpvLifvkks..

wQEECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES
 .   ..  | ...|| .|.||.|.....  ... ....|.|.||. .|..|  ....|.  ||| | .|. || . |
.saankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1200-1467 3.4e-37 122.9 In-house 18-279 (439) alignment 
Range on Protein: 1200-1467
Range on HMM: 18-279/439.0
NSSHLKDEFQTLNSVTPRLQAeDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGC
.   .|..|...||. |  .. ..|.|    .. |||. |. . |     |  | |   | ||||  .. | ..  .| ||.|  .|..||||||..  .
kqeifkeifekinstspdyac.iaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviekkt

TSIVMLNEVDLSQGcpqYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWAsHREVPGSKRSFLKLILQVEKWQEEcEE
. |||| ..  |     ||| ..   || | | .       . . | |.. |     |    | ||.|. |  ...||      |...  ..  ... ||
vtivmltnlvesyk...ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawp.dknvpaqashvldflrainsandk.ee

gEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
  |  ..||  | ||.|   |. | .| .| .| ||.   || ||. . .||.|  || | |.  || .
.ygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
0040438 (Phosphotyrosine protein) phosphatases II 1201-1467 4.4e-73 241.6 In-house 17-276 (317) alignment 
Range on Protein: 1201-1467
Range on HMM: 17-276/317.0
SSHLKDEFQTLNSVtprlQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCT
   |..||..| |.    . ...|.| || |.||||..| || |..   |  ..| ..|.|||| ..| .... .||.||.|||||| ||||.|...|.|
ftalleefedllsl....kldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvt

SIVMLNEVDLS--QGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLtrPQEGYLMVQQFQYLGWAsHREVPGSKRSFLKLILQVEKWQEece
.||||.| .    . | ||||... | ||...|...|.  . ... | ... .|    .  ..|..|.|.||  .  || | ...|... .|....|   
vivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWp.dhgvppspdllldfleavreale...

EGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
...| ...|| .| ||.|.|.|. ...|.... . |||..|||.||. .|..|. ||||||.||..||||
dpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1201-1467 3.6e-25 83.6 In-house 15-277 (307) alignment 
Range on Protein: 1201-1467
Range on HMM: 15-277/307.0
SSHLKDEFQTLNSVTPrlqaEDCSIACLPRNHDKNRFMDMLPPDRClPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTS
 ..|.|||. |   ||    |  .. ..  | ||||. |.   |..   ....|| .|.|| |  .    .|  ||..| || ||. .|| .. .    |
vqalvdefrvlakktp....egvtveafsantdknryqdvkcqdkg.rivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekves

IVMLNEV-DLSQ-GCPQYWPEE-G-MLRYGP----IQVECMSC---SMDCDVINrifrICNLTR-PQEGYLMVQQFQYLGWAShREVPGSKRSFLKLILQ
..|| .| .|..  | |||| | |  | .|     | |. . .   . | |.||    . .|     ..   .|..|.  |   | ||  . . . |.  
vimlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlin....vttlkvdwaqksrtiqhlqwenwpd.rgvpqinltainllea

VEKWQEeceegegRTIIHCLNGGGRSGMFCAIGIVV-EMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
|.  ..         ..||  | ||||   || .|   |.. .|  |. . |. ||. ..  ...  || . . | |||.
vrydtn.......pvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1202-1468 3.9e-32 106.3 In-house 6-260 (267) alignment 
Range on Protein: 1202-1468
Range on HMM: 6-260/267.0
SHLKDEFQTLNSVTPRLQAEDCSIAClpRNHDKNRFMDMLPPDRCLpflITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSI
 ... ||. .. ...  .   .|||    |...||. | || |      . .  .  .||||. ...|..  |||||| || ||. ||. .. |.... |
ceiekefelikkisdtsstisqsiae..knqernrlddnlpyddtr...vilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMLNEVDLsQGCPQYWPEE--GMLRYGPIQVECmscSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWAshreVPGSKRSFLKLILQVEKwQEECEEG
|.|  |   .  ...|| .     .|  . ||    |.. .  .      .|   .|    |  . |  |     .   .. .|| .. .   ... |.|
vlltkvft.dnirlfwPPkmgqakkyqdltveh...slekeendyqiitlelkfknesahnvtlyyykkwn....intnnkpylkplfgila.knqleng

EGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE
.   ...| .| |||| |  |   .| .|...|.|.|. .. .|. .. .|.. |.| .....  || |
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaeyae
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1203-1466 1.3e-17 58.4 In-house 12-268 (281) alignment 
Range on Protein: 1203-1466
Range on HMM: 12-268/281.0
HLKDEFQTLNSVTPrlqAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLI--TIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTS
 .|.||  |    |   .. |..   | |  |||....   |     |     . .|..|| |  . |      .|.|| |  .|  ||||....   |.
dfkqefsnlpgdpp...sdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqentta

IVMLNEVDL--SQGCPQYWPEEGmlrYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYL-MVQQFQYLGWASHrEVPGSKRSFLKLILQVEKWqeece
|||| ..     . | .|.| .    .  .|.. .| | .   .|. .    |    ||   .. .. .  |    .||.|   .||.. ..        
ivmlcqfletnrekcaeyfprna...hcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdw.qvpessevmlkilrkirar.....

egEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQ-NVVDVFHAVKTLRNS-KPNMVEAPEQYRFCYDVALEY
      .|||  | |||| . |. | .. .. .  . |. . |  || . .   |.. .|| . . | |..
..stppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1203-1467 2e-17 57.8 In-house 25-289 (305) alignment 
Range on Protein: 1203-1467
Range on HMM: 25-289/305.0
HLKDEFQTLNSVT-PRLQAEDCS-IACLPRNHDKNRFMDMLPPDRCLPFLitIDGESSNYINAALMDSYRQPA-AFIVTQYPLPNTVKDFWRLVYDYGCT
.|..||. |   | | .             .  |||. |.   |. .  |   .   |.|| |  .     |   ||..| || .|. .|| .| .    
klreefrglakytrpdmtqvafnanqsadiaitknryqdvpcqdqsavkl..dkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkve

SIVMLNE-VDLS-QGCPQYWPE---EGMLRYGPIQVECMSCS--MDCDVINRIfRICNLTRPQEGYLMVQQFQYLGWAsHREVPGSKRSFLKLILQVEkw
 ||||   |.|    | ||||    | .   . | || .| |  |. |   .|  . |||   .  . |...|.  |   | ||  | . |.|.  .   
qivmlcktvelgklkcaqywpaaqgeklelksgivvenvsgskpmerdaeiqi.tllnltysgdqkmsvrhlqwtewp.drgvppckltslellsair..

qeeceEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKR-QNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
       .   ..||  | ||.|   ||  ..| .   ...  . . ||.||. .   ...  || | . | |.|.
.....gskvpivvhcsagigrtgtivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
0046845 (Phosphotyrosine protein) phosphatases II 1204-1468 3.9e-75 248.2 In-house 2-275 (284) alignment 
Range on Protein: 1204-1468
Range on HMM: 2-275/284.0
LKDEFQTLNSVTPRLQaEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG--ESSNYINAALMDSY-----RQPAAFIVTQYPLPNTVKDFWRLVYDY
|..||..|.|.|. |   ..|.|.|| |..|||..| || |..  .| ..||  |.|.|||| ..| |     ... .||.||.||||||.||||.|...
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

GCTSIVMLNEVDLSQ--GCPQYWPEEG-MLRYGPIQVECMSCSMDCDVINRIFRICNLtRPQEGYLMVQQFQYLGWAsHREVPGSKRSFLKLILQVEKWQ
... ||||.| .  .   |.||||.|| .|.||...|...|. .. |.. | ... ||  . . ...|..|.|..|  .. || | ...|... .|....
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhytswp.dhgvppspedlleflrlvrell

EEcEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQN---VVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE
|.  .|.| ...|| .| ||.|.|.|. .. |......   .|||..||| ||. .|.||. .|||||.|...|||| 
en.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
DSPc_SM00195 1204-1467 3.2e-66 218.7 In-house 2-262 (263) alignment 
Range on Protein: 1204-1467
Range on HMM: 2-262/263.0
LKDEFQTLNSVTPRLqaeDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIV
|| ||..|.. |.     ... |. ..|..|||. ..|| |.    | .... |.|.||||  .. .... ..|.||.|||.||.||||.|.. ... ||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNEVDL--SQGCPQYWPEE--GMLRYGPIQVECMSCSMDC-DVINRIFRICNLTRpqEGYLMVQQFQYLGWASHrEVPGSKRSFLKLILQVEKWQEECe
||.| .   .. | .|||||  |  ..| |.|.....  .  ..| | ... . ..  |    |.|.|| .|  | .|| |..|.|.|. .|.|....  
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts.

egEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
  .| ...|| .| ||.|.|..| |... ..... ||.|. || ||...|.||.  |||.|.|...|||.
..sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1204-1467 3.2e-66 218.7 In-house 2-262 (263) alignment 
Range on Protein: 1204-1467
Range on HMM: 2-262/263.0
LKDEFQTLNSVTPRLqaeDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIV
|| ||..|.. |.     ... |. ..|..|||. ..|| |.    | .... |.|.||||  .. .... ..|.||.|||.||.||||.|.. ... ||
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNEVDL--SQGCPQYWPEE--GMLRYGPIQVECMSCSMDC-DVINRIFRICNLTRpqEGYLMVQQFQYLGWASHrEVPGSKRSFLKLILQVEKWQEECe
||.| .   .. | .|||||  |  ..| |.|.....  .  ..| | ... . ..  |    |.|.|| .|  | .|| |..|.|.|. .|.|....  
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts.

egEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
  .| ...|| .| ||.|.|..| |... ..... ||.|. || ||...|.||.  |||.|.|...|||.
..sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_ptpA1_pd Subfamily ptpA1 1204-1425 1.9e-24 81.1 In-house 23-254 (418) alignment 
Range on Protein: 1204-1425
Range on HMM: 23-254/418.0
LKDEFQTLN-SVTPRlqaeDCSIACLPRNHDKNRFMDMLPPDRCLPFLITI-DGESSNYINAALMDSyRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSI
.|.||. |. || |     . |     .|  |||. ..|| ..    |  | | | |.||||  .|    |  ||.|| |||||. ||||.|..  |  |
ikeefrlleesvgps....etsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidg.aypkqfictqgplpntiadfwrmvwenrcrii

VMLNEV--DLSQGCPQYWPEE-----------GMLRYGPIQVECMSCSMDCDViNRIFRICNLTRPQEGYlMVQQFQYLGWASHrEVPGSKRSFLKLILQ
|||.    .    | .||||.           |   .|   || .    | .  . | |   ||   |    . |.|| ||  | ..|   . | .|.  
vmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdper.eiitrnirltfegetr.ditqyqyegwpdh.nipdhtqpfrqllhs

VEKWQEECEEGEGR---TIIHCLNGGGRSGMFCAIGIVVE
. . |..      |    |.||  | ||.| ||.  |...
itnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1205-1469 3.7e-63 208.5 In-house 23-282 (318) alignment 
Range on Protein: 1205-1469
Range on HMM: 23-282/318.0
KDEFQTLNSVTPRLQAEDCsiaCLPRNHDKNRFMDMLPPDRCLPFLITIDGE-SSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVM
. |.. |. ..    . .      | |. |||....|. |..   | ...|| .|.||||  .| ||.  |.| .| |||.|..||||.|.. ... |||
seeyerlsrseetvtslks...lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivm

LNEVD--LSQGCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNltRPQEGYLMVQQFQYLGWASHrEVPGSKRSFLKLILQVEKWQEECeeGEG
| ..     . . .|||..|   || ..|| ..     | . | |.. .  . .|   .|.|..|  |. .  || |  |.|.|. ||.|.|...  |.|
ltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpde.gvpesgaslldlvrqvskaqqks..gag

RTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES
 ...||  | || |.|.|. |..| .| ...||||. ||.||. .. || . .|| |.||| ||.|.|
pivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1205-1468 4.5e-57 188.6 In-house 22-289 (325) alignment 
Range on Protein: 1205-1468
Range on HMM: 22-289/325.0
KDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITI-DGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVM
.| |     ..|  ..    .| .| | .|||| .... |.  . | |  |  ||.||||. . ....   |. .| ||..|..|.||||.|. |. .|.
qdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvvvv

LNEVDLS-QGCPQYWPEE--GMLRYGPIQVECMSCSMDCDVINRIFRIcnlTRPQEG-YLMVQQFQYLGWA--SHREVPGSKRSFLKLILQVEKWQEECE
|||.||  . | .|||.|     ..|...|. ..     | . |.. .    ....|  . |.|||. .|     .. | .  |.|.|. .|..      
lneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldv...kqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtant

EGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE
.. .  ..|| .| ||.|.| ..  ... |  .  ||.|  || ||. .|.|||. .|| ..|.   |.. 
kastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaym
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1205-1466 7e-53 174.6 In-house 23-278 (315) alignment 
Range on Protein: 1205-1466
Range on HMM: 23-278/315.0
KDEFQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFL-ITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVM
|. |.      |  |     .|    |..|||...... |.  ..| ..   . |.|.||...| | ..  .| .| |....||||||||... .. |||
kngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivm

LNEV-DL-SQGCPQYWPEEGMlRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEgylmVQQFQYLGWAsHREVPGSKRSFLKLILQVEKWQEECEegeG
|... .   . . .|||.. .  ||.| |  .|  .  ..  | . .    . .|    | |..|  |    .|| .  ....|| .| .....     |
ltnlvegekrkaekywpdkkv.iyGkitvtrkseevnteytvrtlsvvfgdnire....vvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsv...g

RTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEY
  ..|| .| ||.| |...  |.. .. .|..||..... .|. . .||.. |||.| ||. || 
aivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_CG42327_pd Subfamily CG42327 1206-1390 6e-11 36.6 In-house 9-191 (319) alignment 
Range on Protein: 1206-1390
Range on HMM: 9-191/319.0
DEFQTLNSVTPRLQaedcsiACLPRNHDKNRFMDMLPPDRCLPFLITI-DGESSNYINAALMDSYRQ-PAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVM
.||. |  .  |        .  .  .||.|... .|     . |  | | ....|..|. .  |.. |. .| .| .| ..  ||||.|..     || 
eefrdlPqliarad......evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivq

LNEVD-LS-QGCPQYWPEE----GMLRYGPIQVECMSCsmdcDVINRIFRICNLTRPQEGYLM--VQQFQYlGWAsHREVPGSKRSFLKLILQVE
| ..  |  . |..|.| .    .   || |.|         .| .| .    | .  .. .   .  . |  |  . ||| ...... ..|.|.
ltdlselGikvcaeylPtketldntslyGdilvtlkgr....evkdryaistlllkrvdkeesrelthywy.kwl.eaevPaeeaaliamllevr
subfamily_PTPN14_pd Subfamily PTPN14 1208-1470 1.4e-38 127.7 In-house 26-299 (300) alignment 
Range on Protein: 1208-1470
Range on HMM: 26-299/300.0
FQTLNSVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGESSNYINAALMDSY--RQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLN
|.  . .... .  ..| | || | .|||| |.|| . .   |..   .|..||||. .      .   .||.| ||..||.|||..|.. | . |||| 
fteyeripkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqlivmlt

EV--DLSQGCPQYWPEE----GMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGylMVQQFQYLGWASHReVPGSKRSFLKLILQVEKWQEECE--
|   |  . . .|.|..      ...|  .|     .    || . ...  |   .|    |  .||  |. |. ||   ..||. . .|.  ... .  
eeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeer..tvwhlqytDWpdhg.vPeDvkgflsyLeevqsvrrktnse

----EGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLESS
    | .   ..||..|.||.|.     .... .. ....|. .....||. .  .|..  ||.| |.| ..||..|
veskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylkns
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1213-1467 3.3e-23 77.0 In-house 15-295 (297) alignment 
Range on Protein: 1213-1467
Range on HMM: 15-295/297.0
SVTPRLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGEsSNYINAALM--DSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEV--D
..    ..|. | |  .    |||. |.|  |     |     | ..||||  .      ..  .|..| || .||.|||.||.. .   |||. ..  |
llldeargesfssakrnsslrknryrdilatddtrvkllrvite.rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqed

LSQGCPQYWPE--EGMLRYGPIQVECMSCSMDCdvINRIFRiCNLT---RpqEGYLMVQQFQYLGWASHrEVP----GSKRS-------------FLKLI
  . |  |||.  .. |. | . || .|   |    .|..   .|.   |  .   .|.  |.|.|  |  ||      .|              .| |.
Grdkcapywpsvvqerlkagdvvveflsstsde..fdrvil.telqliyr..sesrvvrhvqflswpdh.Gvpsdledlvrfqaqvcscciavpmmlalv

--------LQVEKWQEECEEgEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
        ||.|  . |    .  ...||  | ||||.     ......... . ||   .. ||. .. .|.. ||. ..||..|. |
emftamvflqleslraempr.nayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkkl
0045098 (Phosphotyrosine protein) phosphatases II 1217-1468 1.8e-63 209.9 In-house 19-273 (278) alignment 
Range on Protein: 1217-1468
Range on HMM: 19-273/278.0
RLQAEDCSIACLPRNHDKNRFMDMLPPDRCLPFlitidgessNYINAALMDSYrqPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEV--DLSQGCP
  .  ... | .. | ||||..| || |..  .         .|||| ..|.|  | .||.||.|||.|| ||||.....|.|.||||.|.  .  . |.
lgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekca

QYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGY--LMVQQFQYLGWASHrEVPGSK--RSFLKLILQVEKWQE----------ECEEGE
|||||.|.|.||...|...|...  |.. | ....|||  .|..  . |....||.|  | .|| .   .|||.|. .......           .....
qywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdh.gvpslpilksflellefirealkllaslllsslllldsg

GRTIIHCLNGGGRSGMFCAIGIVVEMVkrQNVVDVFHAVKTLRNSKPN-MVEAPEQYRFCYDVALEYLE
|....||  | ||.|...|. .. |..  ...||...|||.||. .|. .|. .|||||.|...||.|.
gpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1219-1465 6e-45 148.3 In-house 21-264 (283) alignment 
Range on Protein: 1219-1465
Range on HMM: 21-264/283.0
QAEDCSIACLPRNHDKNRFMDMLPPDRclpFLITIDGESSNYINAALMD---SYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEV--DLSQGC
   |. ||.  .|. |||. ...| |.   . . .. || .||||. .    ||.|   .|..| || .||.|||..|.|   |.|||| ..  || . |
pdldadiasadenkrknrnqeivpadq...wrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikC

PQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLmVQQFQYLGWASHREVPGSkRSFLKLiLQVEKWQEECEegEGRTIIHCLNGGGR
 ||||..|   ||.  |           | . . . . .  ..  | .  .|. .| .  | .    |..|.  .|   | | .  .|  ..|| .|.||
sqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidWleygeqaii.nslvkf.nkvislqtesk..kgPivvhCstgiGr

SGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE
...|.|.   |. .. . |||||  || .|. .. .| . .||.. ....||
tavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1220-1465 6.9e-52 171.7 In-house 14-253 (284) alignment 
Range on Protein: 1220-1465
Range on HMM: 14-253/284.0
AEDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNevdlSQGCPQYWP
. | . | |..| ||||....|. |.    |  ..| | |.||||. .  |...  .| || ||.||..||||....| |..||.|      . | ||||
gtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt....kdkcsqywp

EEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRpQEGYLMVQQFQYLGWASHrEVPGSKRSFLKLILQVEKWQEEcEEGEGRTIIHCLNGGGRSGMFC
 ..  ...  .|.  | .   . . | ... . .. ...   ..|| .|||  .  || .   ...|. .|.. ..  |...   ..||  | ||.|.. 
lkivikeerfkvkvdsveeseeyvvrdielsedgk.ekdirkirqfhflgwpdv.gvpdypsdlmrlvkkvrhltsk.enhranivvhcsagvgrtgvyi

AIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE
.. ......|... |||.. |. ||. ....|.   || |.|   ||
vldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1221-1468 1.1e-35 117.9 In-house 10-265 (270) alignment 
Range on Protein: 1221-1468
Range on HMM: 10-265/270.0
EDCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGE-SSNYINAALMD-SYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVD--LSQGCPQY
.. ..    |..  ||..|.||  .    | ... .  ..||||  .     .....| .. |||.|.|.|||....   |.|||. ..     . | .|
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPEEGM----LRYGPIQVECMSCSMDCDVINRIFRICnlTRPQEGYLMvqQFQYLGWASHREVPGS-----KRSFLKLILQVEKWQEECEEGEgRTIIHC
||.|      |..| |.|  .| . .   | .  |.   .. .|  |.   |.|  |  |  .. .      .. ||.. .| ....| ...|  ...||
Wpaepkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlv..HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHc

LNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE
 .| ||.|.. |. |.|....... ||| . .. ||. ....|. ||||.| | . .|| |
saGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveyae
0040439 (Phosphotyrosine protein) phosphatases II 1222-1467 9.7e-67 220.5 In-house 2-246 (249) alignment 
Range on Protein: 1222-1467
Range on HMM: 2-246/249.0
DCSIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLS--QGCPQYWP
..|.|.|| |.||||..| ||.|.. . |  ..| . |.|||| ..| |... .||.||.|||.||.||||.....|.|.||||.. .    ..| ||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

EEGMLRYGPIQVECMSCSMDCDVINRIFRICNLtrPQEGYLMVQQFQYLGWAsHREVPGSKRSFLKLILQVEKWQEECeEGEGRTIIHCLNGGGRSGMFC
..|.| || ..|...|. .  |.. | ... ||       ..|...||..|  .  || |  ..|..| .|.|..||. . .|....|| .| ||.|.|.
lggsleygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfi

AIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
|. ...|.... . ||...|||.||. .|..|. ||||||.|...||.|
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 1222-1467 2.7e-61 202.5 In-house 1-242 (243) alignment 
Range on Protein: 1222-1467
Range on HMM: 1-242/243.0
DCSIACLPRNHDKNRFMDMLPPDRCLPFLitiDGesSNYINAALMDSYRQpaaFIVTQYPLPNTVKD----FWRLVYDYGCTSIVMLNEVD--LSQGCPQ
..|||.|| |..|||..| || |.   .|   .|  |.|||| |.. ...   .|.||.|||.||.|    |||.....|.|.||||.| .    ..|.|
sfsiallpenlsknrysdilpydhsrvkl...eg..sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPeEGMlRYGPIQVECMSCSMDCDVINRIFRICNlTRPQEGYLMVQQFQYLGWAsHREVPGSKRSFLKLILQVEKWQEE-----CEEGEGRTIIHCLNG
||| ... .||...|...|..   |.. | ....| . ... ...|....||.|  .  || |  ..|... .| ...||     .. ..|....||  |
ywp.gev.tygdftvtllseehlddytvrtlllen.ldlddltrlvihyhylpwp.dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

GGRSGMFCAIGIVVEMVkrqNvVDVFHAVKTLRNSKPN-MVEAPEQYRFCYDVALEYL
 ||.|...|. .. ...   . ||...|||.||. .|. .|. |.||||.|...||.|
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPN1_pd Subfamily PTPN1 1222-1465 6.6e-37 121.8 In-house 23-269 (290) alignment 
Range on Protein: 1222-1465
Range on HMM: 23-269/290.0
DCSIACLPRNHDKNRFMDMLPPDRClpfLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEV--DLSQGCPQYWPE
... | ||.|...||. |. | | .    |... .. .||||.|..  .    .|.|| ||||||. ||..|..  . ..||||.|    .. | ||||.
ptreaklpenrnlnryrdvspydhs...rikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPq

E---GMLRYG--PIQVECMSCSMDCDVINRIFRICNLTRPQEgyLMVQQFQYLGWASHrEVPGSKRSFLKLILQVEKWQeECEEGEGRTIIHCLNGGGRS
.     | .    ..|. .|  .    . |.... ||.  .     . .| |. |.    || |  .|||.. .| .      .  | ..|||  | |||
geeekellledtklkvkliseerksyytvrllelenlktqet..reilhfhyttwpdf.gvpespaaflkflfkvresG.slssdvGpavihcsaGiGrs

GMFCAIG-IVVEMVKRQN--VVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE
| || .  ..|.. |...   ||. . .  ||. .  .. ...| || |   ||
GtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1222-1467 3.8e-16 53.9 In-house 26-270 (285) alignment 
Range on Protein: 1222-1467
Range on HMM: 26-270/285.0
DCSIACLPRNHDKNRFMDMlppdRCLP-FLITIDGESSNYINAALMDS-YRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVD--LSQGCPQYW
.|. ..   | | ||. |.    ||.    . .     .|| |. |    .. ...| || |||.|. |||...|.   . ..||  .     . |  |.
nctytayeanpdlnryadv....rcieetrvvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyy

PEE--GMLRYGPIQVECMSC---SMDCDVINRIfRICNLTRPQEGYLMVQQFQyLGWASHREVPGSKRSFLKLIlqveKWQEECEEGEGRTIIHCLNGGG
||.   ....|  ..    |   ..   ..| .  . |        | ... | . |   .  |   | ...|     || .. .  |    .||  | |
peklgevvkfgkyeitlteckeeaiagtilnal.tvintedasseplymnhvq.vpwwpdqlapedarpmiely....kwvkkvnpkekpicvhcsagvg

RSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
|.  |  |      .  .  ....  |. .|  . . |..  |. | | | .||.
rtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
0042113 (Phosphotyrosine protein) phosphatases II 1223-1468 4.3e-64 211.6 In-house 1-244 (245) alignment 
Range on Protein: 1223-1468
Range on HMM: 1-244/245.0
CSIACLPRNHDKNRFMDMLPPDRCLPFLITIDGES-SNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLS--QGCPQYWPE
.|.|.|| |.||||..| || |...  |  ..|.  |.|||| ..| ||..  ||.||.|||.||.||||.....|.|.||||.| .    ..|.||||.
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

EGMLRYGPIQVECMSCSMDCDVINRIFRICNLtrPQEGYLMVQQFQYLGWAsHREVPGSKRSFLKLILQVEKWQEEceEGEGRTIIHCLNGGGRSGMFCA
...|.|| ..|...|.  . |.. |.... ||  .   ...|....||.|  .  || . ...|...  |.|...|   ..|....||  | ||.|.|.|
gesltygdftvtllseehlddytvrtlevtnl..gddesrevihyhylpwp.dhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfia

IGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE
. ...|....   |....||| ||. .|..|. |.||||.|...||.|.
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallellk
subfamily_PTPN9_pd Subfamily PTPN9 1224-1467 9.4e-48 157.7 In-house 35-290 (297) alignment 
Range on Protein: 1224-1467
Range on HMM: 35-290/297.0
SIACLPRNHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWP--
  . |. |  |||. |.|  |.   .| ..|. | |.||||  .| |.|. ||| || ||..||.||||.|..  .  |||   |       | ||||  
lasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWple

EEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGylMVQQFQYLGWASHrEVPGSKRSFLKLILQVEKWQEECEEG----------EGRTIIHCL
|| . ..| ..|. ..  .  |   |.. | | .  ..    |  ||.|.|  .  || |  |.|... .| . |    .           .   ..|| 
eessaefgdlsvsnveveeeedykvrvleiknvkteesr..kvthfqflsWPdy.GvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcs

NGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
 | ||.| |... | .. ......|||...||.||. .  ..  |||| |||   ||| 
aGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1224-1455 2.1e-18 61.1 In-house 45-269 (301) alignment 
Range on Protein: 1224-1455
Range on HMM: 45-269/301.0
SIACLPRnhDKNRFMDMlPPDRCLPFLITIDGESsNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNE--VDLSQGCPQYWPEEG
| | ||.  ||.|.  . | .      .  ||.    | |  ...  .|  ||.|| ||.|| .||| ..  |    |||| .   .| . | .| | . 
syaylpk..dkhryptv.PckPstavevivdGkr.vPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvki

--MLRYG--PIQVECMSCSMDCDVINRIFRICNLTRPQEGYlMVQQFQYLGWAsHREVPGSKRSFLKLILQVEKwqeeceeGEGRTIIHCLNGGGRSGMF
   |. |   |... .   .. ....| ... . |.  .    |  .||  |. .|.|| |.    .|.  | |        |   ..|| .| |||  |
sekldigrfkikiknkelilnkkiskrtlevedstgkfatr.tvthyqysewt.drgvPkshaelfdlmelvkk.......sekPivvhcsaGiGrsvaf

CAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQ
 .  ..   |. .. ... .|.| ||. . | |   .|
igteylareveadptieltealkhlrehrwngvqtnsq
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1225-1469 9.2e-62 203.5 In-house 3-244 (250) alignment 
Range on Protein: 1225-1469
Range on HMM: 3-244/250.0
IACLPRNHDKNRFMDMLPPDRCLPFLITID-GESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEV-DLSQGCPQYWPEEGM
.|  |.|..|||..|... | .   | . .  . |.||||. ...|..  |||.|| ||..|..||||.|...  ..||||... .  . ..|||| |. 
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPveka

LRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEgyLMVQQFQYLGWAsHREVPGSKRSFLKLILQVEKWQEECEEgeGRTIIHCLNGGGRSGMFCAIGI
 .|| ..|. .|  .  |.. | . . . .. .|   .|.|.... |   . ||   .. |.|. .|.. |.....  .  |..| .| |||| |.||  
ekyGdvtvsllskeefadytkrklklskakkade..rivrqlhfvvWP.dkgvPevatavLellkkvqasqqqagn..aPvivqCsaGvgrsGafiaida

VVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES
|.| .|...|||||. .|.||. .|..||. ||| |.| ..|..|.|
vlerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1225-1468 1.9e-54 179.6 In-house 38-278 (315) alignment 
Range on Protein: 1225-1468
Range on HMM: 38-278/315.0
IACLPRNHDKNRFMDMLPPDRCLPFLITID-GESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG--CPQYWPE--
.|  . |. |||. ..|| |.    |  ||    |.||||. . |. .  |.| .| ||. .|.||||.|...  |.|||... . .    | ||||.  
varetinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrk

EGMLRYGPIQVECMSCSMDCDVINRIFricnLTRPQEGYLMVQQFQYLGWASHrEVPGSKRSFLKLILQVEKWqeeCEEGEGRTIIHCLNGGGRSGMFCA
    ..| |.|| .| . | | ..| .     ||  | .  | |||. .|  .  |.    |.|||| .|       .. |   ..||. | ||.|....
adsvefGsikvellsleadtdgvarkl....vtrkseesrtvtqfqftewPdk.Gvdkqtssllklikevkad...ngkkefsllvhcsaGvGrtGvvis

IGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE
|  ||. .||...||||. ||.||. .| .| . |.| | ||. ||.| 
idevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1226-1468 9.7e-45 147.8 In-house 23-269 (274) alignment 
Range on Protein: 1226-1468
Range on HMM: 23-269/274.0
ACLPRNHDKNRFMDMLPPDRCLPFLITIDGE--SSNYINAALMDSYR-QPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG--CPQYWPEE
  ..... |||. ..|| ..    | . ..|   |.||||  .  |. .  |.. || ||||||.||||..|   .. |||| ..  ..   | .|.|..
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

GML----RYGPIQVECMSCSMDCDVINRIFRICNLTRPQEgylmVQQFQYLGWASHrEVPGSKRSFLKLILQVEKWQEECEEGEGRTIIHCLNGGGRSGM
  .    ||| ....  .     |   | . . .|.|...    |. . |  |  | ..| . ...|.|.|.||. .|| ..  . ...||  | || |.
edyeiserygdveikvekiverndysvrklvlkylerers....vkhywytdWPdh.ksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGc

FCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE
| || | |  .....||||.. |  ||  .  ||.. |||.. . .  .||.
fiaisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1226-1323 3e-08 27.6 In-house 91-184 (244) alignment 
Range on Protein: 1226-1323
Range on HMM: 91-184/244.0
ACLPRNHDKNRFMDMLPPDRCLPFlITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQgcpQYWPEEGML
|  | |  |||    || |      ..    .  ||||...    . | .|.||.|| .|  |||... .     .|.|  |.  .   .|||.   |
afnpnnswknregaglpfdfnrvp.lskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed...eywpdsepl
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1227-1469 1.5e-13 45.1 In-house 39-278 (312) alignment 
Range on Protein: 1227-1469
Range on HMM: 39-278/312.0
CLPRNHDKNRFMDMLPPDRCLpflITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEV--DLSQGCPQYWPE-EGML
.. . .| ||. ..   ||     .|. |.   || | ..    .|  |..|| || ||.  ||.|.   |.|||..|  .  | |. | .|  .  |..
aflkfkdlnrypniqcwdrgr...ftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfv

RYGPIQVECMSCSM-------DCDVINRIFRICNLTRPQEGYLmvQQFQYLGWASHrEVPGSKRSFLKLILQVEKWQEeceegegRTIIHCLNGGGRSGM
     .|   .|.           .  |....   .  ||  |  ...|.  |  |  .| |  . |.|.  | | .          | ||  | ||.| 
dledhrvyteycteieiggkskdkithrvlkvvvkatgqeskl..nhyqwaswpdh.gmpdscdtalrllsavkkdkk.......pviahcsagvgrtgt

FCAIGIVVEMV---KRQNVVDVFHavkTLRNSKPNMVEAPEQYRFCYDVALEYLES
.. |  ..  .   ..||| |.|     ||. .   |..  || ..  . ||.| |
laliesmiaalrhprkqnvkdsfv...llrkdrarsvrvfpqyvyalrcvleflys
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1228-1462 1.7e-15 51.4 In-house 49-285 (310) alignment 
Range on Protein: 1228-1462
Range on HMM: 49-285/310.0
LPRNHDKNRFMDMLPPDRCLPFLiTID-GESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDlSQGCPQ---YWPEEGML
  ..  |||. |..  | .   | .||     .|| |  . .    ..||..| ||  |. ||||....  . ||..|  |   .| |.   |||  |. 
ykkymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvg.eegrpkcvgywpslgvt

-RYGPIQVECMSCSMD-CDVINRIFRIC--NLT-RPQEGYL---MVQQFQYLGWAsHREVPGSKRSFLK--LILQVEkwqeeceegEGRTIIHCLNGGGR
  || |.|  .| | .  .. |    .   |.    |   |    |.  ..  |   | ||  |   .   |. ||           |  ..||  | .|
etygcirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwp.drgvpdekchtvpqrllaqvr.........hgpcvvhcsagkdr

SGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDV
 .. .|. . .. ..| . ||. . .  |..|.   .... || .   |
lyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrv
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1229-1465 3.4e-11 37.3 In-house 45-277 (303) alignment 
Range on Protein: 1229-1465
Range on HMM: 45-277/303.0
PRNHDKNRFMDMLPPDRClpfliTIDGESSNYINAALMDSYRQPAAfIVTQYPLPNTVKDFWRLVYDYG--CTSIVMLNEVDLSQGCPQYWPE-EGMLRY
 .| |||||.|..  |        .    | || |. ..   .  | |.|| ||. |  |||... .    |  ... .    . |    .|. . .|..
vknmdknrfvdvicldhs.....kvklsdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GPIQVEC---MSCSMDCDVINRIFRICNLTrpQEGYLMVqqFQYLGWaSHREVPGS-KRSFLKLILQVEKWQEECEEGEGrTIIHCLNGGGRSGMFCAIG
    .         .      ..  . | .     .| |   .|  |  | ..|.     |.| | |..       ...  |.   | | ||.| |. . 
eersirvgefkrvelgdgwvlkvlsvsngd..yksflhv..hhykaw.phnsipsdgspkfvkqiwqlqsvlrkysdstp.tvymslsgcgragtfalfe

I-VVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE
   . . . |. .|. . ....|| .   |.   |. . | .  |
tahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllae
subfamily_PTPRK_pd Subfamily PTPRK 1230-1465 1.2e-115 380.7 In-house 42-275 (314) alignment 
Range on Protein: 1230-1465
Range on HMM: 42-275/314.0
RNHDKNRFMDMLPPDRCLPFLITIDGE-SSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVdLSQG---CPQYWPEEGMLrY
 |..|||..|.|..||...|||||||. ||.||||||.|||..||||||||.||..|||||||||||..|.|||||.|.  ..|   | .||||...  |
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltel.vevgrvkClkyWPedtev.y

GPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHrEVPGSKRSFLKLILQVEKWQEEceeGEGRTIIHCLNGGGRSGMFCAIGIVVE
|.|.||............||||...|.|.||.. .|.|||.|||..| .|| |....|||. .|.|.|||   ..||...||..|.||.|.|.|| ||..
gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh.dvPvsatgllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivld

MVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE
|..|..|||||.||||||..|.||||. |||.|.|||.||
mieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1230-1467 6.7e-52 171.2 In-house 42-276 (515) alignment 
Range on Protein: 1230-1467
Range on HMM: 42-276/515.0
RNHDKNRFMDMLPPDRCLPFLITI-DGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQ--GCPQYWPE--EGMLR
 |. |||. ..|| |.    |  | |   |.|.||. . |.    |.| .| |.. .|.||||||...  | |.|...   .    | .|||.     ..
infkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvk

YGPIQVECMSCSMDCDVINRIFRicnLTRPQEgYLMVQQFQYLGWASHrEVPGSKRSFLKLILQVEKWQEECEegeGRTIIHCLNGGGRSGMFCAIGIVV
.| |.|| .| . . . | | ..   ... .. .  | ||.. .|  .  ||   .|.|||| .|   ... .      ||||. | || |....|  ||
fGsikvelvsleactggikrklt...vlkgdd.srtvtqfhfteWPdk.Gvpkhtssllklikevkadhgqyt...hpliihcsaGvGrtGvvisidsvv

EMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
  .|  ..||||. |. .|. .| .| . ||| | |.. ||.|
ahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1230-1465 2.7e-27 90.5 In-house 2-237 (237) alignment 
Range on Protein: 1230-1465
Range on HMM: 2-237/237.0
RNHDKNRFMDMLPPDRCLPfLITIDGESSNYINAALMDSYR-QPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEV--DLSQGCPQYWPEEG-MLRY
.|. |||. ..   | .   ..   | .|.||||. ....   |  .| .| || .. .|||..|..  |. ||||  .     . | .|||.      |
enkiknrygnivaydhsrv.vlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GPIQVECMSCSMDCDVINRIFRICNLTRpQEGYLMVQQFQYLGWAsHREVPGSKRSFLKLILQVEKWQEECEEgEGRTIIHCLNGGGRSGMFCAIGIVVE
| . |        .|   | . . . .. ...  ...|.|.  |  .| ||    ..|..  .. .  .   |  |  ||||  | ||.|.|  |  .. 
gvltvslkkkeefsdytvrslllskrlt.lkevrlihqyqftswp.drgvpqqtaallrfrkniinrsphvse.sgpwiihcsagvgrtgiflvidamlr

MVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE
  | ..|||..  |... . .| .... .|| | ... ||
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1230-1467 1.8e-19 64.9 In-house 42-271 (288) alignment 
Range on Protein: 1230-1467
Range on HMM: 42-271/288.0
RNHDKNRFMDMLppdRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVdLSQ---GCPQYWPEEgMLRYG
 |  ..|. ..    ||    . .. ..  ||.| .. | . .  .| .| ||  |.. .|... . .   ||||.|. | .      .|.| . . .  
anptrdryenlp...rcditrvklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcel.lekGkeksaeyfPsk.lGeka

PIQVECMSCSMDCDVINRIFRICNLT--RPQEGYLMVQQFQYLGWASHrEVPGSKRSFLKLILQVekwqEECEEgegRTIIHCLNGGGRSGMFCAIGIVV
 |.  |     . . |... ..  |   .. |   .|..  .| |  .  || .  |.|.|.  .    .....     ..|. .| ||.| .  | |..
rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWddd.gvPenylsplrllevl....kslqk...PivvhssaGvGrtgtlililial

EMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
|... .. . . . .. ||... . ...  || . . . ||.|
eslrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
Y_phosphatase Protein-tyrosine phosphatase 1231-1465 7e-66 217.4 Pfam-A 1-235 (235) alignment 
Range on Protein: 1231-1465
Range on HMM: 1-235/235.0
NHDKNRFMDMLPPDRCLPFLiTIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLS--QGCPQYWP--EEGMLRYG
|..|||. |.|| |.    | . ....|.||||  ...|... .||.|| ||..|..||||.|... ...||||.... .  . |.||||  ||..|.||
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

PIQVECM-SCS-MDCDVINRIFRICNLTRPQEGYLMvQQFQYLGWAsHREVPGSKRSFLKLILQVEKWQeecEEGEGRTIIHCLNGGGRSGMFCAIGIVV
 |.||.. . .  . ... | ... . ....|   . .|..| .|  ...|| |..|.|.|| .|||..   |. .| ...|| .| ||.|.|.|. |..
dikvelkekekedekeytlrklelkkkkeesekrev.kqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldill

EMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE
|...... |||...||.||...|.||.  ||| |.|.. ||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1231-1465 7e-66 217.4 In-house 1-235 (235) alignment 
Range on Protein: 1231-1465
Range on HMM: 1-235/235.0
NHDKNRFMDMLPPDRCLPFLiTIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLS--QGCPQYWP--EEGMLRYG
|..|||. |.|| |.    | . ....|.||||  ...|... .||.|| ||..|..||||.|... ...||||.... .  . |.||||  ||..|.||
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

PIQVECM-SCS-MDCDVINRIFRICNLTRPQEGYLMvQQFQYLGWAsHREVPGSKRSFLKLILQVEKWQeecEEGEGRTIIHCLNGGGRSGMFCAIGIVV
 |.||.. . .  . ... | ... . ....|   . .|..| .|  ...|| |..|.|.|| .|||..   |. .| ...|| .| ||.|.|.|. |..
dikvelkekekedekeytlrklelkkkkeesekrev.kqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldill

EMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE
|...... |||...||.||...|.||.  ||| |.|.. ||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1231-1469 1.1e-54 180.6 In-house 51-286 (297) alignment 
Range on Protein: 1231-1469
Range on HMM: 51-286/297.0
NHDKNRFMDMLPPDRCLPFLITIDGE-SSNYINAALMDSYRQpaAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLS-QGCPQYWPEEGMLRYGPI
| .|.|. ..|| |.    |  .. . .|.|.||. . ....   .| || | ..||.|||..|.|.  . |||||. . . . | .||...|.  .| .
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdv

QVECMSCSMDCDVINRIFRICNLTrPqEGYLMVQQFQYLGWASHREVP-GSKRSFLKLILQVEKWQEECEEGegRTIIHCLNGGGRSGMFCAIGIVVEMV
 |. .| |  .  |.| . . .   .     .|.|.|.. | .. .    | .|.|||| .|.|  .. .||    ..|||.| || |....|  ||  .
svvllsvsereGfikrelevtkgk.a.karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaeg..PllvhclaGvGrtgvlltidsvvaea

KRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLES
||.. ||.|  || ||...|..| . |||.| | . ||.| |
krekevdifglvkklrqerpylvqtkeqykfvyvavlealls
0041856 (Phosphotyrosine protein) phosphatases II 1231-1468 1.7e-43 143.6 In-house 1-172 (182) alignment 
Range on Protein: 1231-1468
Range on HMM: 1-172/182.0
NHDKNRFMDMLPPDRCLpflitidgeSSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNevdlsqgCPQYWPeegmlrygpiqv
|.||||..| ||.|. .          ..|||| |..... .  ||.|| ||..|| ||.|.....|.|.||.|.       ...|||            
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.......eelywp............

ecmscsmdcdvinrifricnltrpQEGYLMVQQFQYLGWASHREVPgsKRSFLKLILQVEKwqeeceeGEGRTIIHCLNGGGRSGMFCAIGivveMVKRQ
                        .. . .. |..||.|  |   .   ...|..| .|..        .|....||  | ||.|...|.     ..|..
........................ellerlgiqylylpwpDhgvpd..ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaay....lmkkl

NvVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE
. |....|||..|. .|.||. |.||.|.....||.|.
g.vsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1231-1465 6.2e-28 92.6 In-house 7-238 (239) alignment 
Range on Protein: 1231-1465
Range on HMM: 7-238/239.0
NHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSY-RQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEV--DLSQGCPQYWPEEgMLRYG
|. |||. ...  |.    |  .     |.||||. .  |   | |.| ||  .  .  ||||....     ||||  .     . | ||||.    .| 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

PIQVECMSCSMDCDVINRIFRICNLTRPQEGYlmVQQFQYLGWAsHREVPGSKRSFLKLILQVEKwqeECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEM
 ..|      . .| | | | . .. . .| |  | |...  |   . ||    . | |  .. |   .   |    .|||  | ||.| |  |  ..  
nlrvtlrktevfadyiirtfvmsqvgqteery..vyqyhftvwp.dkgvpqyatavlglrrkitk...dslpgarpwvihcsagvgrtgaflvidamlrq

VKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALE
 |.|. ||.|  ||..|. .| ||.. ||| | .   ||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1231-1464 7.1e-28 92.4 In-house 8-238 (239) alignment 
Range on Protein: 1231-1464
Range on HMM: 8-238/239.0
NHDKNRFMDMLPPDRCLPFLITIDG-ESSNYINAALMDSY-RQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEV--DLSQGCPQYWPEEgMLRYG
|. |||. ...  |.    |  .     |.||||. .  |   | |.| ||  .  .  ||||....     ||||  .     . | ||||.    .| 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tskyc

PIQVECMSCSMDCDVINRIFRICNLTRPQEGYlmVQQFQYLGWAsHREVPGSKRSFLKLILQVEKwqeECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEM
 ..|      . .| | | | . .. . .| |  | |...  |   . ||    . | |  .. |   .   |    .|||  | ||.| |  |  ..  
nlrvtlrktevfadyiirtfvmsqvgqteery..vyqyhftvwp.dkgvpqyatavlglrrkitk...dslpgarpwvihcsagvgrtgaflvidamlrq

VKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVAL
 |.|. ||.|  ||..|. .| ||.. ||| | .   |
akkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1231-1468 1.8e-12 41.6 In-house 48-288 (305) alignment 
Range on Protein: 1231-1468
Range on HMM: 48-288/305.0
NHDKNRFMDMLPPDRCLPFLitIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVD--LSQGCPQYWPEE--GMLRYG
...|||. |.   |.    |        .|| |  . .  .|  || || || .|  ||| . ..    .| || ..    .. | .|.. .   .| . 
eagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

----PIQVECMSCSM---DCDVINRIFR-ICNLTRPQEGYLMVQQFQYLGWAsHREVPGSKRSFLKLIlqvekwqEECEEGEGRTIIHCLNGGGRSGMFC
     |.| . |..      |   .. . .  .  | |  . |... .  |   | || .  . |.|.       |..    | ...||  | ||.|   
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwp.drgvpaadlailell.......ekarpskgpivvhcsagigrtgsvv

AIGIVVEMV-KRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE
 .  ... .   | . |  . .. .|. . | ... .|| | ..| |.|..
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyfr
subfamily_eak_pd Subfamily eak 1233-1371 4.5e-09 30.1 In-house 54-191 (332) alignment 
Range on Protein: 1233-1371
Range on HMM: 54-191/332.0
DKNrFMDMLPPDRCLPFLITIDGESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVML-NEVDLS-QGCPQYWPEEG--MLRYGPI
..|  ....| || |  | .   .   ||||.|..       .|.|  .  . |  ||..|..    .||.| ..|.|  .   .|.|...   |..| .
nrn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGil

QVECMSCsMDCDVINriFRICNLTRPQEGYlMVQQFQYLGWAS
.||. .  .  ....  .|   |..  | .  |. ... ||. 
dverkef.vkrnile..trllelskGneth.rvlhykvfGwte
0046846 (Phosphotyrosine protein) phosphatases II 1248-1468 9.9e-37 121.7 In-house 2-174 (176) alignment 
Range on Protein: 1248-1468
Range on HMM: 2-174/176.0
PFLITIDGESSNYINAALMDSYRqpaaFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVD--LSQGCPQYWPEegMLRYGPiqvecmscsmdcdvinri
............|||| |....|    .|.||.|||.|. ||.......|.| .|.|.|     . .||.||||  . ..|                   
rlrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpe..leklgi..................

fricnltrpqegylmvqQFQYLGWASHrEVPGSkRSFLKLILQVEKWQEEceeGeGRTIIHCLNGGGRSGMFCAIGivveMVKRQNVVDVFHAVKTLRNS
                 |...|.|  |  || . . .|.|. .......|   | |....||  | ||.|...|.     ...... ..|..|....|. 
.................qylhlpwpDh.gvpdl.elllellefirealke...g.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreq

KP-NMVEAPEQYRFCYDVALEYLE
.| ..|. ||||||.|...|..|.
RplgavqtpeQyrflyefellllk
0044763 (Phosphotyrosine protein) phosphatases II 1255-1467 4.2e-23 77.3 In-house 15-171 (178) alignment 
Range on Protein: 1255-1467
Range on HMM: 15-171/178.0
GESSNYINAALMDSYrqpaaFIVTQYPLpntvKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEGMlrygpiqvecmscsmdcdvinrifricnlt
 |.| ||||  .. .     ......|      |...|....|.|.||.|.| .    ..|..|||||                                
lersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag..............................

rpqegylmvQQFQYLGWASHReVPGSKRSFLKLILQVEKWQEeceEGEGRTIIHCLNGGGRSGMFCAIGIVVEMvkrqNVvDVFHAVKTLRNSKPnMVEA
          |......  |  || . . ||...  .|....   | .|....||  | ||||...|. .. ..    .. ....|.. .|. .| .|. 
.........iqylhipipDhg.vpdllehflefvefieeald...ekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerRp.ivpn

PEQYRFCYDVALEYL
|.|.|..|...|..|
pgqlrqLyefelrll
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1255-1320 5.2e-07 23.3 In-house 87-156 (349) alignment 
Range on Protein: 1255-1320
Range on HMM: 87-156/349.0
GESSNYINAALMDSYR--QPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLS--QGCPQYWPEE
|   .||||  .   |      .| || ||| ||.||....   |   .. ||. .    . | .|| | 
gklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
subfamily_PTPRD_pd Subfamily PTPRD 1256-1469 2e-66 219.8 In-house 74-283 (564) alignment 
Range on Protein: 1256-1469
Range on HMM: 74-283/564.0
ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQ--GCPQYWPEEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTR
|.|.||||  .|.||.. |.| || ||..|..||||.|... ...||||...  ..   | .||||.|  .|| ..|. ...    |.. | |.. . ..
egsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkks

PQEgyLMVQQFQYLGWASHrEVPGSKRSFLKLILQVEKWQEeceEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAP
 .    .|.||..  | .|  || | .|.|.|| .|....|   ...| ...|| .| ||.|.|..| ...| .| ...||..  ||.||. .. ||. .
ses..reVrqFhFtsWPdh.gvpesatslLdlirkvralne...pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqte

EQYRFCYDVALEYLES
||| |.... ||.|..
eQYiFiheailealac
0043147 (Phosphotyrosine protein) phosphatases II 1256-1461 3.5e-35 116.6 In-house 3-155 (172) alignment 
Range on Protein: 1256-1461
Range on HMM: 3-155/172.0
ESSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVdlsqgcpqywpeegmlrygpiqvecmscsmdcdvinrifricnLTRPQ
|.|.|||| ..| |. |  ||.||.||.||. ||||.....|.| ||.|.|                                            |. |.
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

EGYLMVQQFQYLGWASHREVpgSKRSFLKLILQVEKWQeeCEEGEGRTIIHCLNGGGRSGMFCAIGIVVemvkrqNVVDVFHAVKTLRNSKPNMVEAPEQ
  . .. |..||.|  |     . . .|... ......  ... .|....||  | ||.|...|. ..         .....||...|. .|..|. |.|
llerlgiqylylpwpDhgvp..llellleflefidell..alspggpvlVHCsaGvgRtgtlvaaylml......lglsleeavalvrekRpgavqnpsq

YRFCYD
|||.|.
yrflyy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1256-1321 8.5e-09 29.6 In-house 81-154 (350) alignment 
Range on Protein: 1256-1321
Range on HMM: 81-154/350.0
ESSNYINAALMDSY----RQPAAF--IVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEEG
....||||  .       .. . |  | || |||.||.||.....  . . |..|.. .    . | .||.| .
stnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqegs
0051429 (Phosphotyrosine protein) phosphatases II 1257-1468 1.9e-41 137.9 In-house 3-226 (272) alignment 
Range on Protein: 1257-1468
Range on HMM: 3-226/272.0
SSNYINAALMDSYRQ---PAAFIVTQYPLPNTVKDFWRLvYDYGCTSIVMLNEVD--LSQGCPQYWP------------EEGMLRYGPIQVECMSCSMDC
 |.||||  .. | .   | ... ...|||.|..||||| ...|...||.| ...   ...|..|||            .. . .|| . | ..|...  
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DVINRIFRICNLTRPQEGyLMVQQFQYLGWASHREVPGSKRSFLKLILQvekwqeeceegEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVD-----
|.| | ... .|  ..|. ..| ...|..|  |   . . ...|.|.|.           .|. ..||  | .|.|...|. .... | .. .||     
dyilrellltlllsagea.revmhlhytdwpdhgvpqeallellellld...........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---VFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE
   ...||. ||   |..|. .|||.|.|...||.|.
nlyleeaveelraqrpgavqteeqylflyeallellr
0051082 (Phosphotyrosine protein) phosphatases II 1257-1463 1.5e-26 88.2 In-house 2-149 (151) alignment 
Range on Protein: 1257-1463
Range on HMM: 2-149/151.0
SSNYINAALMDSYrqpaaFIVTQYPLPntvkDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPEEGmlrygpiqvecmscsmdcdvinrifricnltrpqe
 |.|||.  ....     ......||.    ||..|....|...||.|.. .  . ||.|.||.|                                   
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg...................................

gyLMVQQFQYLGWASHrEVPGSKRSFLKLILQVEKwqeeceEGEGRTIIHCLNGGGRSGMFCAIGIVVEMvkrqnvVDVFHAVKTLRNSKPNMVEAPEQY
  . | ....|.|  .  .| |  ..|... ....       ..| ...||  | ||.|...|. .. ..      |... |.. .| . |..|  ..|.
..ievlhipildwpdp.glplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

RFCYDVA
.|.. . 
lfqlfal
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1257-1306 7.9e-10 32.8 In-house 69-118 (347) alignment 
Range on Protein: 1257-1306
Range on HMM: 69-118/347.0
SSNYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNE
. .||||. .        .|.||||||.||.|||..|.    | .| . |
vetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtife
0036282 (Phosphotyrosine protein) phosphatases II 1258-1461 3.3e-38 126.4 In-house 2-164 (174) alignment 
Range on Protein: 1258-1461
Range on HMM: 2-164/174.0
SNYINAALMDSYRQPAAFIVTQYPLPntvkdFWRLVYDYGCTSIVMLNEVDLSQ--GCPQYWPEegmlrygpiqvecmscsmdcdvinrifricnltRPQ
|.||||  .| .. .  .|..|.||.     ||......|.|..|||.|    .  .|..||||                                 ...
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

EGYLMVQQFQYLGWASHREVPGSKrsFLKLILQVEKWQEEceEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKrQNVVDVFHAVKTLRNSKPNMVEAPEQ
  . .. |..||.|  | . . |.  .|... .||....|   ..| ...||  | ||.|...|. ..  . . ...||... |..||. .|.||. |.|
dlerlgiqylylpwpDhgvpdlsi..llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YRFCYD
|||.|.
yrflyy
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1258-1461 2.8e-15 51.3 In-house 46-253 (290) alignment 
Range on Protein: 1258-1461
Range on HMM: 46-253/290.0
SNYINAALMdSYRQPAAFIVTQYPLPN-------TVKDFWRLVYDYGCTSIVMLNEVDLSQ------GCPQYWPEE--GMLRYGPIQVECMSCSMDCDVI
..|| |  . .. .  ..|.|| |. .       |...|| .. .   ...||| |..  .       | .| ||.  . |... ..|.| |   . ||.
ddyiHAnrv.tcpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddve

NRIFRIcnlTRPQEGYLMVQQFQYLGWAsHREVPGSKRSFLKLILQVEkwqeeCEegEGRTIIHCLNGGGRSGMFCAIGIVVEMVK-RQNVVDVFHAVKT
.|   .   .  .|  . |.  .. ||  ...|. .....|.|| .|.     ..  .   |.|| .|  || .. || .   ..   .. | .  ..|.
tRelvv...kfddeeeftvtHsllkgWn.klnvqedtktllsliqkvk.....as..ktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlka

LRNSKPNMVEAPEQYRFCYD
||. . ...  .... |   
lrkqralaitsalelafvda
subfamily_egg_pd Subfamily egg 1259-1464 2.8e-20 67.2 In-house 69-267 (307) alignment 
Range on Protein: 1259-1464
Range on HMM: 69-267/307.0
NYINAALMDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQGCPQYWPE--EGMLRY--GPIQVECMSCSMDCDVINRIFRIcNLTRP
..| |  ..       ||..| || |||.||||.|.   .  ||||.    |. |. |||   .  |..  | ...|..      | . |. .. .|  .
dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtkl.klvGg

QEGYLMVQQFQYlGWASHREVpgskRSFLKLILQVEKWQEeceegegRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVV--DVFHAVKTLRNSKPNMVEA
..  . .. .|.  .    .|     | |... .. .  .        ..... .|  ... . || | .  . |  ..   | .||. ||  ..  ||.
ddeerflehwqg.dvnnssdv....ysplrvlrklrnlsk.......pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsves

PEQYRFCYDVAL
. .| | | . |
vllylfvyrlvl
0049260 (Phosphotyrosine protein) phosphatases II 1266-1461 1.9e-31 104.2 In-house 2-144 (152) alignment 
Range on Protein: 1266-1461
Range on HMM: 2-144/152.0
MDSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWpeegmlrygpiqvecmscsmdcdvinrifricnltrpqegylmvqQ
.| |..| .|| ||.|.|||..||||.....|.| ||||.| .     .|.||.                                             |
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi.............................................q

FQYLGWASHReVPGSKRSFLKLILQVEKWqeeCEEGEGRTIIHCLNGGGRSGMFCAIGIVVemvkrqNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYD
...| |  |  || .   .| |.| .||.   ... .|....||  | ||.|...|. ..       . |....||. .|. .|..|. |.|.||.|.
ylhlpwpDhg.vpdlsqlllflllfiekl...aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1267-1330 3.6e-13 43.6 In-house 230-293 (440) alignment 
Range on Protein: 1267-1330
Range on HMM: 230-293/440.0
DSYRQPAAFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDlSQGCPQYWPEEG-MLRYGPIQV
. | .  ||| || ||  || ||||||.||  ..|.|||...  . |  ||| .   . .||. |
egyskknafiatqmpldstvldfwrlvhdyristiimlnqln.dktcsiywpvntrsvtfgpftv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1274-1462 1.1e-18 62.1 In-house 6-199 (199) alignment 
Range on Protein: 1274-1462
Range on HMM: 6-199/199.0
AFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG--CPQYWP--EEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGW
 .|.||.|| .|. |||..|.. |   |||.|. .  .    | |||  | |  .|| . | . . .   |     . ..| |        . ..|.  |
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

AShREVPGSKrSFLKLILQVEKWQ-EECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEM--VKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDV
   .  |     |. ...   .      .| .   |.|| .| | .|.| |. | |      .  |||.|   | ||...  .. . ..| | |.|
ke.kttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1274-1462 1.1e-18 62.1 In-house 5-198 (198) alignment 
Range on Protein: 1274-1462
Range on HMM: 5-198/198.0
AFIVTQYPLPNTVKDFWRLVYDYGCTSIVMLNEVDLSQG--CPQYWP--EEGMLRYGPIQVECMSCSMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGW
 .|.||.|| .|. |||..|.. |   |||.|. .  .    | |||  | |  .|| . | . . .   |     . ..| |        . ..|.  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

AShREVPGSKrSFLKLILQVEKWQ-EECEEGEGRTIIHCLNGGGRSGMFCAIGIVVEM--VKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDV
   .  |     |. ...   .      .| .   |.|| .| | .|.| |. | |      .  |||.|   | ||...  .. . ..| | |.|
ke.kttpnva.lfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1281-1455 9.3e-06 19.3 In-house 99-276 (302) alignment 
Range on Protein: 1281-1455
Range on HMM: 99-276/302.0
PLPNTVKDFWRLVYDYGCTSIVMLNEVD--LSQGCPQYWPEE--GMLRYGPIQVECMSCSMDCDVIN--RIFRI-----CNLTRPQEGYLMVQQFQYLGW
|  .|.. .| |. .|  . .| | ..     . | .|. ..  | |..|   |. .|   | .     . |..      |  . ..    |. ... .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

ASHReVPGSKRSFLKLIlqveKWqeeCEEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQ
  |   |    . |...    |.   ||      ..|| .| ||.| . ||   ... ....| |. . |. .|. .   |   .|
pdhG.apkeaytaldil....kf...cesykknvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqq
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1282-1466 4.9e-10 33.9 In-house 39-220 (255) alignment 
Range on Protein: 1282-1466
Range on HMM: 39-220/255.0
LpnTVKDFWRLVYDYGCTSIVMLNEVDL--SQGCPQYWPEE--GMLRYGPIQVECMScsMDCDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHrEVPG
|  ||. |.. .   . . .||| .      . | .|.| |  . |..  ..| .       ||. |  .|      .     |. ..| ||  .   | 
l..tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk..ssadvvlrtleitstlgekkkthtvkhysykGWiek.naPe

SKRSFLKLILQVEKWQeeceegegRTIIHCLNGGGRSGMFCAIGIVVE-MVKR---QNV--VDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEY
  |  |...  | . .          ..|| .|.|||  |  . .|   |..     .   .|    .. ||....  .. | |  |.  . |..
lareilnilkvvrdsk........svvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvldl
subfamily_hpo-7_pd Subfamily hpo-7 1282-1466 2.4e-09 31.5 In-house 43-226 (263) alignment 
Range on Protein: 1282-1466
Range on HMM: 43-226/263.0
LPNTVKDFWRLVYDYGCTSIVMLNEVDLS--QGCPQYWPEE--GMLRYGPIQVECMSCSMdcDVINRIFRICNLTRPQEGYLMVQQFQYLGWASHREVPG
| .|.. |.. .   . . .||| .      . | .|.| |  . ...  ..| .       ||. .   . .    .     |....| ||  ....  
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs..dvllktlellstlgeKkkthtvkhysykgWiekndpel

SkRSFLKlILQVEKWQEEceegegrTIIHCLNGGGRSGMFCAIGIVVE-MVKRQ---NV--VDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEY
. |. |. ||.| .   .        ..|| .|.|||  |  . .|   |..     .   .|    .. ||.|..  .. | |  |   . |..
a.reiln.ilkvarnsks.......lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLdf
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1330-1468 2.5e-20 67.2 In-house 252-386 (392) alignment 
Range on Protein: 1330-1468
Range on HMM: 252-386/392.0
VECMSCSMDCDVINRIFRIcnlTRPQEGYLMVQQFQYLGWASHRE-VPGSKRSFLKLILQVEKWQEEceEGEGRTIIHCLNGGGRSGMFCAIGIVVEMVK
.. .| | | ||  .  .    .|       | |.|. ||  |        ||.||||  |    ..  . |   ..||| | ||.|.||.    .  . 
lqdlstssdGdvrskqlke...frslkashtvtqyqfhgwpkhgsdqqsgarsllkliravkgstns..kkefsilvhclsgagrtgvfctameciaqia

RQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYLE
. . ||.| .|| ||  . ..|.. |.| | |||  ||| 
egdsvdifqtvkilradrmqfvqteeeyafvydvireylh
0048076 (Phosphotyrosine protein) phosphatases II 1343-1466 2.4e-17 58.4 In-house 28-142 (145) alignment 
Range on Protein: 1343-1466
Range on HMM: 28-142/145.0
NRIFRICNLTRPQEGY-LMVQQFQYLGWASHrEVPGSKRSFLKLILQVEKWQEEceegEGRTIIHCLNGGGRSGMFCAIGIVVEmvkrQNvVDVFHAVKT
. | .. |||. .|..  .. |..||.|  | .|| . . .|... ..|....|    .|....||  | ||.|...|. .. .    .. |....|.. 
lgittvlnltselellerlgiqylylpwpDh.gvpdllellleflefieealke....ggpvlVHCsaGvgRtgtlvaaylmll....lg.vsleealel

LRNSKPNMVEAPEQYRFCYDVALEY
.|.  |..|. |.|.||.|.. ||.
vrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 1344-1461 1.3e-16 56.1 In-house 29-139 (144) alignment 
Range on Protein: 1344-1461
Range on HMM: 29-139/144.0
RIFRICNLTRPQEGYLMVQ---QFQYLGWASHrEVPGSKRSFLKLILQVEKWQEeceeGEGRTIIHCLNGGGRSGMFCAIGIVVemvkRQNvVDVFHAVK
 |  ..||| . | . . .   |...|.|  | .|| .   .|...  .|...|     .|....||  | ||.|...|. ...    ... .....|..
gittvinlteeyepefleregiqylhlpwpDh.gvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaaylmk....klg.lsleeala

TLRNSKPNMVEAPEQYRFCYD
 .|.  |..|. |.|.||...
lvrsrrpgavpnpgqlrfLle
PTPc_DSPc_SM00012 1361-1465 1.1e-26 88.5 In-house 2-105 (105) alignment 
Range on Protein: 1361-1465
Range on HMM: 2-105/105.0
VQQFQYLGWASHrEVPGSKRSFLKLILQVEKWQEECEEgEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQ-NVVDVFHAVKTLRNSKPNMVEAPEQYRFC
|....|.||  | .|| .  |.|.|. .|.|.....|. .. ...|| .| ||.|.|.|. |........ . ||.|  || ||...|.||.  ||| |.
vkhyhytgwpdh.gvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

YDVALE
|.. ||
yralle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1361-1467 3.2e-17 57.0 In-house 91-194 (440) alignment 
Range on Protein: 1361-1467
Range on HMM: 91-194/440.0
VQQFQYLGWAShREVPGSKRSFLKLILQVEKWQEECeeGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCY
..|..| ||   . ||      ||.| .|.. ||..  |.|  ..||  | ||.|.  |.  ..  .|| . .|.|  ....||..|.||..|||| | .
lkqyhyqgwpd.kgvpkfagpvlkmiqdvnesqeka..gngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafvh

DVALEYL
.. || |
eavlegl
subfamily_CG42327_pd Subfamily CG42327 1398-1466 4.3e-09 30.5 In-house 245-314 (319) alignment 
Range on Protein: 1398-1466
Range on HMM: 245-314/319.0
EGEGRTIIHCLNGGGRSGMFCAIGIVVEMVKRQ-NVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEY
|  |  ..|| .| ||.|.  |  | .. ..   . ||. . |  .|. . . | . ||| | | |. ||
esqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1404-1467 5.6e-11 36.6 In-house 1-64 (69) alignment 
Range on Protein: 1404-1467
Range on HMM: 1-64/69.0
IIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
..||  | ||.| | || . .  .| . .||.|  |. .|  .| ||   ..| | .|   | |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalveal
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1404-1467 1e-10 35.9 In-house 2-65 (69) alignment 
Range on Protein: 1404-1467
Range on HMM: 2-65/69.0
IIHCLNGGGRSGMFCAIGIVVEMVKRQNVVDVFHAVKTLRNSKPNMVEAPEQYRFCYDVALEYL
..||  | ||.| | || . .  .| . .||.|  |. .|  .| ||    .| | .|   | |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalveal