Gene PTPRT in Homo sapiens

Synonym: RPTPrho, RP5-1121H13.2, PTPRT

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRK
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP103_AA protein Get Run
HsapP103_AA_890-1164 phosphatase_domain Get Run
HsapP103_AA_1176-1458 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
MAM MAM domain 32-191 1.4e-36 114.1 Pfam-A 1-160 (160) alignment 
Range on Protein: 32-191
Range on HMM: 1-160/160.0
CSFDEHysNCGYSVALGtNGFTWEQINTWEK-----PMLDQAVPT--GSFMMVNSSGRASGQKAHLLLPTLKENDTHCIDFHYYFSSRDRsspGALNVYV
|.|.|.   ||.|     . ..|..... ..     |  |.   .  |..|.|..| .| |..|.||.|.|......|..|.|. |....   | |||||
CdFeee..lCgwsqdet.ddldWtrvsgstptektgpssdhtlgkesghymyvetssgaegesarllspllpasssaClrFyyhmsgsev...gtLnvyv

KVNGGPQGNPVWNVSGVVTEGWVKAELAISTFwPHFYQVIFESVSLKGHPGYIAVDEVRVLAHPCRK
. ..... ...|..||  .. | .||...|.. .. .||.||.|  ||. |.||.|....  ..|..
reekegeetllweisgnqgssWqeaevtlsai.tkkfqvvfeavrgkgsegdialDdislsegeCse
fn3 Fibronectin type III domain 296-372 1.8e-08 27.6 Pfam-A 7-83 (85) alignment 
Range on Protein: 296-372
Range on HMM: 7-83/85.0
ELLAVGATYLWIKPNANSiIGDGPIILKEVEYRTTTGT--WAETHIVDSP-NYKLWHLDPDVEYEIRVLlTRPGEGgTGP
 . .|..|.| .. .. .  |.|||   |||||...|.  | | ..  .  ...| .| |. |||.||  .. |.| .||
svsevtstsltlsWsppk.dgggpitgYeveyrekgggeewkeftvprtttsvtltgLkpgteYefrVq.avngag.egp
fn3 Fibronectin type III domain 501-577 8.6e-13 41.4 Pfam-A 15-84 (85) alignment 
Range on Protein: 501-577
Range on HMM: 15-84/85.0
KIYIQWKPPNETNGVITLYEINYKAVGSLDpsadlssqRGKVFKLRNET-HHLFVGLYPGTTYSFTIKASTAKGFGPP
.. ..|.||.. .| || ||. |. .|. .          | |.. . | .. . || |||.|.|...| ...| ||.
sltlsWsppkdgggpitgYeveyrekggge........ewkeftvprtttsvtltgLkpgteYefrVqavngagegpe
0045450 (Phosphotyrosine protein) phosphatases II 884-1164 6.2e-98 323.6 In-house 5-305 (307) alignment 
Range on Protein: 884-1164
Range on HMM: 5-305/307.0
FQPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTA---SWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGD-PHSDYINANYI--------DGYH
. . |.. .||... ....   .|...|.| |.. ..    ....|.  ||..|||| .|. |||.||.| .|||. ..||||||.|.        |||.
lslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgyd

RPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD--TEVYGDIKVTLIETEPLAEYVIRTFTVQKK-GYHEIRELRLFHFTS
..|..||||||..|||.|||||.|....  |||.|.||| ||.||..||||.  . .||...|||...| |..|..||..|. . | .| |... ||.|.
lkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytg

WPDHGVPCYATGLLGFVRQVKFLNPP--EAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGV---VDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEAC
||||||| .   || |...|.  .    . ||..|||||| ||||.|||...||.. |.||.   ||....|..||.|| . ||..|||.|...|.|| .
wpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell

L
|
l
subfamily_PTPRK_pd Subfamily PTPRK 885-1200 3.3e-175 576.4 In-house 1-314 (314) alignment 
Range on Protein: 885-1200
Range on HMM: 1-314/314.0
QPAIRVADLLQHITQMKRGQGYGFKEEYEALPEGqtasWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQ
.||||||||||.|...||..|||||||||.|.||    ||.||.||||.|||.|.|..||.|||.| ..||||.||||||..||.|.||...|.||||.|
hpairvadllqsiallkraegygfkeeyeslfeg....wdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlq

ETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQK--KGYHEIRELRLFHFTSWPDHGVPCYATGLL
||||||||....||.|||||.|.|||||||||..|||.||||||||||.|.|||.|||.|.|.|.|.|  .|..||||.| |.|..||||.||..|||||
etvkdfWrlvydencasivmltelvevgrvkClkyWPedtevygdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgll

GFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNI
..||.||  ...|||.|||||||||||||.|||||..|||.|.|||||.||.|..||...||.|.|||||.|..|.||||||||.|||||.||..||...
klvrrvkksqeeeaGrivvhCsaGaGrtGtfiaidivldmieregvvdvfnavktlrsrkvnmveteeqykfiydvileaclcgetaipvsefkalyles

SRLDPQTNSSQIKDEFQT
.||||||||||.|.||||
irldpqtnssqlkeefqt
subfamily_PTPRD_pd Subfamily PTPRD 886-1237 1e-148 491.5 In-house 3-354 (564) alignment 
Range on Protein: 886-1237
Range on HMM: 3-354/564.0
PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQE
..| ||.| .|. ..|  ... |.|||. . |||. .|..|....|..|||| ||. ||||||.|  ..||. ||||||..||||.....|||||||..|
kpipvaelkehvaklkansdlkfeeeykkieegqqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyrkrkayIAtqgPlae

TVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD-TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGF
|..|||||.|..||..|||.|.|.| |.||| .|||.. || ||...||| |.| ||.|.||||...||  .| || | |||||||||||| .||.|| .
tiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdl

VRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISR
.|.|. ||.|.||||||||||| ||||.||.|| ||. ...|..|||...|..||.||  .|||||||.|.|.|||||  |||| ... ....   ....
irkvralnepdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqteeQYiFiheailealacgntevesenlkqhlqkLae

LDPQTNSSQIKDEFQTLNiVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCL
 ...|...... ||| |.  . .. .|. . .  |.|..|||  ..|.|..| 
veedtemtgleleFqrLa.takeieleefavatkpknkkknrfsnilalescr
0050432 (Phosphotyrosine protein) phosphatases II 886-1168 4.6e-105 346.6 In-house 24-304 (308) alignment 
Range on Protein: 886-1168
Range on HMM: 24-304/308.0
PAIRVADLLQHITQmkRGQGYGFKEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYDHSRVRLlvldgDPHSDYINANYIDGY--HRPRHYIATQGP
  ..| |||... .    . ....||.|.|.. ..  ....|.  ||..|||| .|. ||||||.|     |..||||||.|.|||  ..||..||||||
lklsvldllkllek..aldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgyssklprkfIatqgP

MQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD----DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYA
...||.|||||.|..|.  |||.|.||| ||.|| .|||.    ....||...|||...| |..|..||......|. | |... ||.|.||||||| ..
lpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpsp

TGLLGFVRQVKFLNppEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNT
. || |...|.  .  . |||||||||| ||||.|||.|..|.. | || ||.|..|. || || . |||.|||.|...|.|| ...  |
eilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyralleylklklt
subfamily_PTPRA_pd Subfamily PTPRA 886-1197 2e-104 344.0 In-house 12-329 (330) alignment 
Range on Protein: 886-1197
Range on HMM: 12-329/330.0
PAIRVADLLQHITQMKRGQGYGFKEEYEALPEGQ-TASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQ
. . | .| . | . .  .   |.||..||| |.  |. ..|...||..|||. ||. ||.||| | |..| ..|||||| .||||..  ..||.||| .
fplpvekleeeirirsaddnklfreefnalPagpiqatlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPke

ETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEV-YGDIKVTLIETEPLAEYVIRTFTVQKKGY----HEIRELRLFHFTSWPDHGVPCYAT
|||.|||||||. .||.|||.|.| |  . || .||||.  | ||.|.|.. ... | .| .| | ||...     .. | .| |||||||| |||  . 
etvedfwrmiweqksativmltelkerkeekcaqywPdeGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepi

GLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLY
|.| ....|| ||. .|||||||||||.|||| ||..|..|.. . |..||.|. |..||.|| ..|||.|||.|.. ..||  | |.| . |  . .  
GmlkllkkvkklnqqsagpivvhcsaGvGrtGtfivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlleyylygdteldvsslekhl

YNISRLDPQTNSSQIKDE
 ..    ..|.   ...|
qklynkitgtdkigleee
subfamily_Ptp69D_pd Subfamily Ptp69D 886-1180 8.5e-92 302.5 In-house 2-303 (307) alignment 
Range on Protein: 886-1180
Range on HMM: 2-303/307.0
PAIRVADLLQHITQMKRGQGYGFKEEYEALPEG-QTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQ
.|| . || . ... ||   .|...||| |..     |  .....||  |||| .|...|. ||.| .. |. .||||||..| ||.  ...|| |.|..
gaiaiddleealksrkrdtdfglakeyekLeareidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPve

ETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP-DDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKG-----YHEIRELRLFHFTSWPDHGVPCYA
.|..||||||.. ..  |||..|| |  | || .||| .|.  |||| |.|...|   .|.||.. | ||.      .. |..  .|.|.|.|  ||  |
atigDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPeva

TGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSL
.||| ...||. |.  . .|||||||||.||.| |.|.| .|.  ..|  ||||. |..|| ||  |||  |||||.. |.|.    |.| . | .. . 
rgllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldyssygdtdedvddleda

YY
. 
ie
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 886-970 2.9e-14 47.2 In-house 4-86 (440) alignment 
Range on Protein: 886-970
Range on HMM: 4-86/440.0
PAIRVADLLQHITQMKRGQGygFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGY
  | |||. ... . .| .   |..|.  || | .   | |   .|. |||| ||..|||||| |  . | |.|||||| ||.| 
rpiivadfadyvqnnrrsra..fedewsllpsglsqpsdiaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyingi
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 887-1199 3.1e-107 353.3 In-house 4-319 (319) alignment 
Range on Protein: 887-1199
Range on HMM: 4-319/319.0
AIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQET
 |.|..| .......     ....|.. | |... ..|.|...||..|||| ||..||..|| |  ||| . ||||||..||||.. . .||||.|...|
eievqeLkerlkalastgetllekefkllkeavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlent

VKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDT-EVYGDIKVTLIETEPLAEYVIRTFTVQKKGYH-EIRELRLFHFTSWPDHGVPCYATGLLGF
..|||||.|.|.|  .||.|.||| ..||. .|||. . |.|| . ||| | | |..|.|| ....||  . | ||.  |..|.||||.|| .||.|| .
iedfWrmvWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldl

VRQVKF-LNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNIS
.....   . ...||||||||||.|||| ||..| ||.  ..|||.|.|. |..||.||  .||..||| |...|.|||  .|.| | | ..|    ...
lkrirksrektqsgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveagdteievqdlrdrlkqla

RLDPQTNSSQIKDEFQ
  ...|  .... |||
ekvadtgetglerefq
subfamily_PTPRB_pd Subfamily PTPRB 887-1163 7e-107 351.8 In-house 6-285 (293) alignment 
Range on Protein: 887-1163
Range on HMM: 6-285/293.0
AIRVADLLQHITQMKRGQGYGFKEEYEALPE-GQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQE
 |.. .. .|...||. . ..|.|||| | . |.. . ..|.. .||.|||| ||..||||||.|  |.....|||||||||.||. ||..||||||. |
piklekfeehvkkmkadsdlrfseeyeelkavgkdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpe

TVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD--TEVYGDIKVTLIETEPLAEYVIRTFTVQKkgYHEIRELRLFHFTSWPDHGVPCYATGLLG
||.|||||.|...|  |||.|.||| |.||| .|||.|  . .||||||||...| | ..|||.....|   .|.|..| .|||||||||||  .. || 
tvddfWrmvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlld

FVRQVKFLN--PPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEAC
|||.|.       ...||||||||| |||| |||.|..|.  |.| .||||  | ||| .|..|||||.||.|.|...|. .
fvrtvreaiektaskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
0051299 (Phosphotyrosine protein) phosphatases II 887-1163 2.4e-106 350.6 In-house 4-286 (288) alignment 
Range on Protein: 887-1163
Range on HMM: 4-286/288.0
AIRVADLLQHITQMKRGQGYGFKEEYEALPEGQ-TASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQE
.|.| .||... ...... .|..||.|.|.. . . .. .|.  ||..|||| .|. ||||||.| ||||...||||||.|||||...|..||||||...
eisveellklvlkllangltglleefeellsllpdltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrkfIatqgPlpn

TVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP-DDTEVYGDIKVTLIETEPLAEYVIRTFTVQKK----GYHEIRELRLFHFTSWPDHGVPCYATG
||.|||||.|..|.  |||.|.||| ||.|| .||| .....||||.|||...| |..|..||..|...    | .| |. . ||.|.||||||| ... 
tvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspel

LLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEAC
|| |.|.|.  ...  ||.||||||| ||||.|||.|..|.. |.||.||... |. || || ..|||.|||.||..|.||..
lldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 887-1199 9.2e-81 266.5 In-house 4-324 (325) alignment 
Range on Protein: 887-1199
Range on HMM: 4-324/325.0
AIRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQET
.| | .|..|. . |  .  ||  |.. ||  .. .  .|   ||..|||. |....|.||| |  .. ||.||||||.|.  . .   ..|.| |. .|
siavvnlvehvekkkaqdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltat

VKDFWRMI--WQensASIVMVTNLVEVGRVKCVRYWPDD---TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGL
..|.||..  |.   .|.|.|.| .. |  .|  |||..   .  .| ..| |.  | ...|| | . |..    | | .. |.. ||.| ||. . . |
indlWrlvldWr...csvvvvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatl

LGFVRQVKFL------NPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEF
. ... || .      |   ..||.|||||| |||| ||.. ..|.   .|  ||||. |. ||..| ..|.| .||.....|. || ..||| .||. |
isilqlvkavservtantkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveaymsgntdvpvssf

RSLYYNISRLDPQTNSSQIKDEFQ
 .   ..   .| |.  .|. ||.
eaklsslqernpltqklniekefe
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 888-1201 2.9e-115 379.7 In-house 2-318 (318) alignment 
Range on Protein: 888-1201
Range on HMM: 2-318/318.0
IRVADLLQHITQMKRGQGYGFKEEYEAL-PEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQET
| | || .|. ....     ..||||.| .. .|...  . |. |..|||| ||..|||.||.|  |.|.. ||||||||||||.| . |||.|.|. ||
isvedleshvrrlresGelllseeyerlsrseetvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpet

VKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD-TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFV
..|||||.|. ||| |||.|...| |..|. ||||.. .. ||...|.| |.  |..||.|.|.|.... .| |. | .|.|||||.|||  ...|| .|
ieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsrsygklvvelkeevelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlv

RQVKFLN-PPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISR
|||.  . ...||||||||||| |||| |||.|..|. ...|..||.|. |..|| ||  .||||.||.|..|..|||  .|.| .   ..||   .. .
rqvskaqqksgagpivvhCsaGvGrtGvfiavdillerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasgdtevdasdlrsrirelre

LDPQTNSSQIKDEFQTL
 ||..  .... ||| |
qdpesgttemdaefqrl
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 888-1198 8.7e-105 345.1 In-house 6-314 (315) alignment 
Range on Protein: 888-1198
Range on HMM: 6-314/315.0
IRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETV
| . .|. ...| |     |||..||..| ||    |.||. ||..|||| |||.||.|||.| .|. ||||||.|||.|||| ..|.|||.|||  ..|
ipldqlityvaqkkastkngfkqdyesipggqlhpldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasv

KDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKgyHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQ
|||||....|. . |||.|||||  . |. .||||.  .|| | ||... |   || .||..|  .   .|||.  .|.||||| ||| |.. |. ..|.
kdfwrlvfeedigkivmltnlvegekrkaekywpdkkviyGkitvtrkseevnteytvrtlsvvfg..dnirevvqlhytswpdmgvpkytiplmnlirt

VKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDP
||  .  ..|.|||||||| |||| ||..|..|| || | ..|..| .. .|..|...||. ||| |..||.||. .||.|.|    .   | ..    |
vkqhhtnsvgaivvhcsaGvGrtGtfitldavldqaeaenaidvynfitgvrqnrikmvqvaeqyqfiydalletfvcgdtsiaqdlylqrydsllapsp

QTNSSQIKDEF
.| |. ....|
dtgstllqeqf
0043336 (Phosphotyrosine protein) phosphatases II 888-1161 3.5e-103 340.1 In-house 2-275 (278) alignment 
Range on Protein: 888-1161
Range on HMM: 2-275/278.0
IRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETV
|.| |||... .....  .....|.| |.. .. ....|.  ||..|||| .|. ||||||.| .|.||..||||||.|.|||..||..||||||..|||
isvkdllkallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpetv

KDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQ
.|||||.|.... .|||.|.||| |||||..|||.....|||..|||...| |. |..||..| ..|..| |. . .|...|||||||.  . || |...
edFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflka

VKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE
|.  .... ||..|||||| ||||.|||....|...|.|| ||....|.||| || . |||..||.|...|.||
vrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealle
subfamily_PTPRG_pd Subfamily PTPRG 888-1186 2.6e-102 337.9 In-house 1-310 (563) alignment 
Range on Protein: 888-1186
Range on HMM: 1-310/563.0
IRVADLLQHITQMKRGQGYGFKEEYEALPEGQTA---SWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHS-DYINANYIDGYHRPRHYIATQGPM
. | .. .|.....  .  ||.||.||| .  ..     ..... ||..|||| ||..||.|||.|  | |  .. |||||||||||.. . .||||||.
vpvkefakhvaslhadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgpl

QETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD-TEVYGDIKVTLIETEPLAEYVIRTFTVQK----KGY--HEIRELRLFHFTSWPDHGVPC
..|..|||||||..|.| |||.||||| || || .||| | .| || ..|||||.| || | .||.....    |.   .. .. | .|.|.||||||| 
kdtfddFWrmiWeqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPe

YATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFR
...  | ||.. .  |. ||||||||||||.|||| .|..||.|   ..| .|..|. .. .|||| .||||||||.|.|||.||| . ..| .   . .
hslpvLifvkkssaankaeaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaiasketellaeqve

SLYYNISRLD
.|      |.
elknctpyle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 888-1176 6.6e-93 306.2 In-house 4-296 (305) alignment 
Range on Protein: 888-1176
Range on HMM: 4-296/305.0
IRVADLLQHITQMKRGQGYGFKEEYEALPEGqTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETV
| ..|| ..|....  .  |....|..|.|    | |  |...|..|||. .|. .|..|..|   . ...||||||.|.|||.|  .||..|||...||
ialddlaayikearvysdkgleaqykslyee.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntv

KDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEV---YGDIKVTLIETEPLAEYVIRTFTVQK-KGYHEIRELRLFHFTSWPDHGVPCYATGLLG
.||||.|..|   .|||.|.||| |. || .|||. .     .|...|.| ...  ..|..| ... . .. .| | .  ...|.||||||| .|| || 
adfWrliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksektasdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatslls

FVRQVKFLNPPEAG-PIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFR
....|.     . | |..|||||| |||| |||.| .|. ...|.|||.|. ...|| .|...||| .||||.|||. |   ||.| | .  .|
likrvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitcgdtsiigsnlr
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 888-1163 8.2e-74 243.1 In-house 2-283 (290) alignment 
Range on Protein: 888-1163
Range on HMM: 2-283/290.0
IRVADLLQHITQMKRGQGYGFKEEYEALPEGQTA-SWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGD--PHSDYINANYIDGYHRPRHYIATQGPMQ
|.| .. ..... .  .  ||......|  |.   .  ..   .|...||. ||. ||  |. |  . |.     .|||| ||.||.  ..|||||||..
ipvdkfgefvanghakgnegfrnqfkmldsgesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvs

ETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD-TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGY-HEIRELRLFHFTSWPDHG-VPCYATGL
.|..|||..||||... |||.|| .| |.|||  ||||  |. || ....|.. | | ||..|.. |..|   .. ...  ...|.|...| |....| |
ntlvdFWkliwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsagakqsvtqyqitnwdstgkvtnpqtil

LGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEAC
| . ...|    .  ..||||||.. ||.. |.|..| .. .. |||.|.|. ....| |. ..|||..|| .... .|.. 
lvieemyktqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyl
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 888-981 2.3e-14 47.4 In-house 5-95 (95) alignment 
Range on Protein: 888-981
Range on HMM: 5-95/95.0
IRVADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVrllVLDGDPHSDYINANYIDGYHRPRHYIATQG
| |. .  |. .|.      | .|. ...    |.. .   . |  |||. ||. || .||   ||     |||||| ..||| |   |||.||
ihvsvfhshvlemhsnsdqefdnefksismtsgapytvgsseanipknrflnifpydatrv...vlttkrdsdyinacfvdgyarkncyiaaqg
subfamily_PTPN9_pd Subfamily PTPN9 890-1163 6.2e-85 279.8 In-house 3-290 (297) alignment 
Range on Protein: 890-1163
Range on HMM: 3-290/297.0
VADLLQHITQMKRgqgYGFKEEYEALPE-GQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVK
. .|.... ....    | ..||... .   .   ...|   | .|||| ... ||..|| |  .|.|..|||||||..|||.... .||||||...||.
ieelvayvkekgk...rGlskeyaeirnepveGtflasklranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvs

DFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP---DDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFV
|||||.|...   |||.| .|| ||.|| .|||   .... .||..|. .|.|   .|..|......   .|.|..  | |.||||.|||  |. || ..
dfWrmvWeqevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveveeeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvl

RQVK--------FL-----NPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEAC
..|.         |      .|.  ||||||||| |||| ||..|  |.  |..|.||....|. ||.||   .||.|||.| . |.||  
ekvrekqalavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
0040438 (Phosphotyrosine protein) phosphatases II 891-1199 7.5e-108 355.8 In-house 3-312 (317) alignment 
Range on Protein: 891-1199
Range on HMM: 3-312/317.0
ADLLQHITQMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDF
 |||... ...... ....||.| |.. .  ....|.  ||..|||| .|. ||||||.| .|.||..||||||.|.||....|..||||||...|| ||
ldlllalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedF

WRMIWQENSASIVMVTNLVEVGRVKCVRYWP-DDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVK
|||.|.... .|||.|.|.| ||.|| .||| ..| .|||..|||...| ||....||..|...|  | |... ||.|.||||||| . . || |...|.
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

FLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQT
  .... ||..|||||| ||||.|||...||.. | || ||....|.|||.|| . |||.|||.|..||.|| .....| .|..|. ...... . ....
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrkltlepaselklkllklliplald

NSSQIKDEFQ
... .. |..
dvklkekelk
0039614 (Phosphotyrosine protein) phosphatases II 893-1168 1.9e-98 324.8 In-house 19-294 (297) alignment 
Range on Protein: 893-1168
Range on HMM: 19-294/297.0
LLQHITQMKRGQGYGFKEEYEALPEGQTAsWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDG-DPHSDYINANYIDGYHR-PRHYIATQGPMQETVKDF
| ...  .|. . .....|.| |.. .   . .|.  ||..|||| .|. ||||||.| ..|| |..||||||.|.|||.. .|..||||||..|||.||
ldlllllekansktllllefeellslkpd.ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetvedF

WRMIWQENSASIVMVTNLVEVGRvKCVRYWPDDTEVYGDIKVTLIETEPLAEYVIRTFTVQKkgYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKF
|||.|.... .|||.|.||| || ||..|||.....|||..|||...| |. |..||..|..  . | |... |..|.||||||| ... || |...|. 
wrmvweqgvtvivmLtklvelgr.kcaqywpeeggtygdftvtllkvehldgytvrtlevtn..ngesrtvthfqytgwpdhgvppslellleflelvre

LNP--PEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNT
 .   |. ||..|||||| ||||.|||...||.. | || ||....|.||| || . |||..||.|..||.|| .....|
alaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrklt
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 893-1162 2e-91 301.0 In-house 2-275 (281) alignment 
Range on Protein: 893-1162
Range on HMM: 2-275/281.0
LLQHITQMKRGQGYGFKEEYEALPE-GQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFW
| .|. |... .  ||.||||.| . |.  .   .|.|||..|||| ||..||..||..   . . ..||||||...||. ...|||||||. .....||
lrkhlkqlsqndnaGfieeyeklaaigvdntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafW

RMIWQENSASIVMVTNLVEVGRVKCVRYWPDDT--EVYGDIKVTLIETEPLAEYVIRTFTVQKKGyHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQV-
.|.|...   |||||. .| |..|| ||||||.    |||..|. ...|  |.|. |.|......  | ||.. ...|.|||||||  .. ||.| ..| 
qmvweqkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeeekatyierkfkleres.getreveqlaytaWPdhGvPattkellefrkevl

KFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENE-GVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEA
|. .. .  |.|.||||| ||||..||.|.... .|.|   .|. . |.||| .|  .|||  || ||. |.|.|
kltekktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavlda
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 893-1177 4.9e-71 234.5 In-house 7-293 (439) alignment 
Range on Protein: 893-1177
Range on HMM: 7-293/439.0
LLQHITQMKRGQGYGFKEEYEALPEGQTA---SWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKD
. .|. .... .   |||..| .   .         | .. .. |||| .. ..||.|| |  . | ||| |||||||.||. .. ||||||| .||..|
fqehvekldknkqeifkeifekinstspdyaciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettdd

FWRMIWQENSASIVMVTNLVEVGRvkcvrYWPDDTEVY-GDIKVTLIETEPLAEYVIRTFTVQKKGY--HEIRELRLFHFTSWPDHGVPCYATGLLGFVR
|||........ |||.|||||  .     ||| |.||. ||| |       | .|||| | | ..    .  | .  ||...|||. ||. |. .| |.|
fwrlviekktvtivmltnlvesyk.....ywpsdaevcygdiavrvdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflr

QVKFLNP-PEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRS
 ..  |   | ||.||||||| ||||  ||.|  |.    |  |||   |. || || ..||.  ||||...|.||    |..|. . ||. 
ainsandkeeygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledivyGdiavtidefkk
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 894-1161 5.8e-94 309.4 In-house 9-277 (288) alignment 
Range on Protein: 894-1161
Range on HMM: 9-277/288.0
LQHITQMKRGQGYGFKEEYEAL-PEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWR
......... .  ||.|||..| . ..| | ..... .| .|||| ||..||. ||.|  |.  . .|||||.||||... ..|||||||...||.|||.
vakvakksarnrtgfseeynsLaalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWe

MIWQENSASIVMVTNLVEVGRVKCVRYWPDDTE--VYGDIKVTLIETEPLAEYVIRTFTVQKKGyhEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKF
.......  |||.|.||| |. || .||||. .   ||...|||.|.. | ..| |.. ..||.  . .|.  .....|||||||  .. ||...|||| 
lvyenktstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrklllekkk..teleitqyqylaWpdhgvPeskapllellrqvkv

LNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE
 |. ..|||.|||||| |||| |||.|...|. |.| ..|... | .|| || .||||..||.|.....|.
anqadtgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevlls
subfamily_PTPN14_pd Subfamily PTPN14 894-1160 8.3e-59 194.0 In-house 12-293 (300) alignment 
Range on Protein: 894-1160
Range on HMM: 12-293/300.0
LQHITQMKRGQGYGFKeEYEALPE-GQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDpHSDYINANYIDGY--HRPRHYIATQGPMQETVKDF
. .| ..|  .|  |. ||| .|.  . |  .||| .|| .|||. ... |...||.|     . ...||||  |      . |.||..|||.. ||.||
rakilekkleegkvft.eyeripkkredallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdf

WRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD-----TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFV
|.|.|... . |||.|.  | |. |...|.|..     |  .|  |||   .|    .. ......    .| |..  . .| |||||||   .| | ..
WqmvWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyL

RQVKFLNPP---------EAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAIL
..|. .            .  |..||||||.||||  |  | ..   |.. ..|| . .. || ||  ||||  || ||.....
eevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 896-1170 2.2e-103 340.6 In-house 17-297 (298) alignment 
Range on Protein: 896-1170
Range on HMM: 17-297/298.0
HITQMKRGQGYGFKEEYEALPEGQT----ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFW
  . .|. .  |...|.. | ...     .... |...||..|||| .||..|.|||.|   |.| .|||||| ....|..   .||||.|..|||.|||
laavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrnafiatqaPltetvedFW

RMIWQENSASIVMVTNLVEVGRVKCVRYWPD-DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKF
||...|....|||.|||.|....|. .||||  .| ||.|.|.| ..|  |....|...|.||  .. ||.| .|||||||.||| .|| .|...|.|. 
rmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra

lNPPEAG--PIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAI
 .. .||  |..|.|||| ||.| |||||..|. ...| |||.|. |. ||..|...|||||||||...|.|||  ..|. |
.sqqqagnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsfndei
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 897-1162 8e-62 203.6 In-house 9-292 (301) alignment 
Range on Protein: 897-1162
Range on HMM: 9-292/301.0
ITQMKRGQgygFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDG--DPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMI
 ....  .   |.|.|..| ||.  | .   ..||.. ||. ||  ||. |. |         . .||||.||||| . ...||.||||..|..||||.|
vaakhsnk...feeqykelkegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrli

WQENSASIVMVTNLVEVGRVKCVRYWPD---DTEVYGDIKVTLIETEPLAEYVIRTFTVQKK-----GYH----------EIRELRLFHFTSWPDHGV-P
|||  .|||||||| |  . || .|||.   ..| .| ..|||...  . ..||| ..|. .     ||           . ...  .. |.||..|| .
wqekpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvr

CYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEA
 ..| |     ...  . .. ||.|||||.. .|.| .....  |. .  |||||.|. .. .| ..   |.| |||....|.| . 
eprtvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmy
subfamily_CG7180_pd Subfamily CG7180 899-1168 4.5e-70 230.6 In-house 10-295 (296) alignment 
Range on Protein: 899-1168
Range on HMM: 10-295/296.0
QMKRGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQEN
. .|     .| |..  |. ..    .. . |||.|||. ... ||. || |  |||. .|||||| |.|.. ... || |..|..|||..|||....|.
dkrrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydee

SASIVMVTNLVEVGRvKCVRYWPDD-TEVYGDIKVTLIETEPLAEYVIRTFTVQKK----------GYHEIRELRLFHFTSWPD-HGVPCYATGLLGFVR
. ..|..|.  .  . ..  ||| .  | ||.| | ..|.. .|. .|||| ..||             | | ..||..| |.  . ||  ...|. ..|
isavvvLtktfdfak.mypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrr

QVKFLN-----PPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNT
.|. .       || ||.||..| ||.|.| ..|||  |...|.|. ||.|. |. || .| .||.. |.| .. | .||| ||. .
rvrlwrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleavlcnkd
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 902-1240 2.2e-93 308.1 In-house 14-353 (515) alignment 
Range on Protein: 902-1240
Range on HMM: 14-353/515.0
RGQGYGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSAS
 ..   | ||.  ||  .      |.|. | .||||.||. || .||.| |.. .|||||.|| || ...  . |||.||| . .|.||||...||| . 
nrhttlfseefhdlpgpniypqtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvtt

IVMVTNLVEVGRVKCVRYWPD---DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYheIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGP
|.|||.| |  ..|| .||||   |.  .| ||| |. .|  .. ..|..|| |     .| .  |||| |||.|||  .. || ....||  .   . |
iamvtklkegdkikcgkyWPdkpgdsvkfGsikvelvsleactggikrkltvlkgdd..srtvtqfhfteWPdkGvpkhtssllklikevkadhgqythp

IVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEF
...|||||.|||| .|.|| ..  |..  .||.|| |. .|..|. ||||.||| |...|.||  |  || |||  |     ..         |.. .||
liihcsaGvGrtGvvisidsvvahakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledllwrntlipvihftdhlqdlhssgdgrgrskmtkef

QTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFL
|||. ..|     ..  |    || |||  . |||.|    |
qtlkslcpdppasqtrsgrtrdnhpknrygnnlplqrnrvil
subfamily_PTPN6_pd Subfamily PTPN6 902-1160 8.2e-85 279.5 In-house 22-294 (306) alignment 
Range on Protein: 902-1160
Range on HMM: 22-294/306.0
RGQGYGFKEEYEALPEG---QTASWDTAKEDENRNKNRYGNIISYDHSRVRLLvLDGDPHSDYINANYIDGYHR--PRHYIATQGPMQETVKDFWRMIWQ
. .  ||.||.|.| .    .. | . ..  ||..|||| ||. .||.|| |   .. | |||||||||..  .   ..|||||| ...||.|||||.||
slekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwq

ENSASIVMVTNLVEVGRVKCVRYWPDD--TEVYGDIKVTLIETEPLAEYVIRTFTVQ-KKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKF---
|||  |||.|. || |. ||.|||||   .| ||.|.|| .. . ||.|..|...|. ||  .| ||.. .||.||||||||     .| |...|.    
ensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqe

-LNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGV---VDIFNCVRELRAQRVNLVQTEEQYVFVHDAIL
 |.  |||||||||||| |||| || ||..|.. |..|.   .|| ..|. .|.||  |||||.|| ||. || 
eleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaik
0047943 (Phosphotyrosine protein) phosphatases II 904-1162 1.5e-97 321.6 In-house 10-271 (273) alignment 
Range on Protein: 904-1162
Range on HMM: 10-271/273.0
QGYGFKEEYEALPEGQ-TASWDTAKEDENRNKNRYGNIISYDHSRVRLlvldGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASI
. ....||.|.|.. .   .. .|.  ||..|||| .|. ||||||.|    ||..||||||.|.|||...|..||||||...||.|||||.|..|.  |
gltllleefelllslkplltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmvweqnvrvi

VMVTNLVEVGRVKCVRYWPDD----TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPP--EA
||.|.||| ||.|| .|||..    ...||...|||...|  . |..||......|..| |. . ||.|.||||||| . . || |...|.  .    . 
VmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalealpsn

GPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEA
||.||||||| ||||.|||.|..||. | || ||....|. || || . |||.|||.|...|.|| 
gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealley
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 906-1169 3.3e-75 247.7 In-house 20-284 (287) alignment 
Range on Protein: 906-1169
Range on HMM: 20-284/287.0
YGFKEEYEALPE-GQTASWDT-AKEDENRNKNRYGNIISYDHSRVRLLvldgDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIV
 |||. .  | . .|.    | .   .|..|||. .|. .|  || |     . | ||||| .||||.  ...|....|| .|...||..|...|   ||
egfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgykekkafiiaesPmfntarnfWkliddrnvtaiv

MVTNLVEVGRVKCVRYWPDDT-EVYGDIKVTLIETEPLAEYVIRTFTVQKKG-YHEIRELRLFHFTSWPDHG-VPCYATGLLGFVRQVKFLNPPEAGPIV
|.... |  . .| .|||...  |.|. ...|.. |  |.|..|.. |..|.   . .... ...|.|...| |....| || . ...|    .  ..||
mlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktqrkrgntsiv

VHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTA
||||.. ||.. |.|..| .. ...|||.|.|. ... | |. . ||| ||| |. |..||   ...| 
vhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsfety
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 906-1201 1.6e-66 219.4 In-house 20-274 (392) alignment 
Range on Protein: 906-1201
Range on HMM: 20-274/392.0
YGFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMV
  | ||.  ||. .     .|... | .||||.||. || .||.| |.|  |.|||.|| ||....  . |||.|||   ...|||||..||| ..|.||
alffeefhdlpgpdiypqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamv

TNLVEVGrvkcvrywpddtevygdikvtlieteplaeyvirtftvqkKGyHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSA
|.| |                                          || .. |    |||| |||..|| ... || |...||      . |...||||
tklkegd........................................kg.ddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsa

GAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISR-LDPQTNSSQIKdEFQTL
| ||||  |.||...  |..  .||.|| | ..| .|  .|||.||| |.. |.||  |  || |||  |     ..|   | ...| |.| ||..|
gvgrtgvvisidsvvahakktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledllwrntlipvvhftdhlqdlstssdGdvrskqlk.efrsl
0046845 (Phosphotyrosine protein) phosphatases II 907-1171 1.2e-101 335.1 In-house 1-282 (284) alignment 
Range on Protein: 907-1171
Range on HMM: 1-282/284.0
GFKEEYEALPEGQTA---SWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGD-PHSDYINANYIDGY-----HRPRHYIATQGPMQETVKDFWRMIWQE
|..||.|.|.  ..    |...|.  ||..|||| .|. ||||||.| .|||| ..||||||.|.|||     ......||||||...||.|||||.|..
gleeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

NSASIVMVTNLVEVGRVKCVRYWP--DDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKG-YHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNP-
|.  |||.|.||| ||.|| .|||  ... .|||..|||...|    |..||......|   | |... ||.||||||||| ... || |.|.|. |.. 
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-PEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEG---VVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIP
 |  |||||||||| ||||.|||.|..|.. |.||   .||....|. || || . |||.|||.||..|.||......| ..
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklkltlle
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 907-1201 1.3e-88 291.8 In-house 20-315 (315) alignment 
Range on Protein: 907-1201
Range on HMM: 20-315/315.0
GFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT
 | ||.  ||. ..    .|.|..| .||||.||. .|..||.| |.| .|.|||||| || ...  . |||.||| . .|.|||||..||. ..|||||
lfseefhdlpdPdiyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvt

NLVEVGRVKCVRYWPD---DTEVYGDIKVTLIETEPLAEYVIRTFtVQKKGyHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHC
.. |  ..|| .||||   |.  .| |||.|...|. .. |.| . | .|. .| | .  |.|| |||.||.  .. || ....||  | ..  ...|||
kkqegdkikcrqywPdrkadsvefGsikvellsleadtdgvarkl.vtrks.eesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhc

SAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTL
|||.|||| .|.|| ... .... .||.|| |..|||.|. ||||||.| |..||.||  |  || |.|  |     ..      .  |.. .||.||
saGvGrtGvvisidevvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledllwrntlilvihftdhlqdlhtsvdgsgrskmtkefetl
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 907-1175 7.6e-75 246.8 In-house 27-296 (297) alignment 
Range on Protein: 907-1175
Range on HMM: 27-296/297.0
GFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRprHYIATQGPMQETVKDFWRMIWQENSASIVMVT
 |.||.  ||| .. .  .|..  | .|.|| ||. || |||.| ... || |||.|| .. |..   ..|.|| ||..||.|||.|...|. . |||..
vfseeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmln

NLVEVGRvKCVRYWPDDTE-VYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPC--YATGLLGFVRQVKFLNPPEA-GPIVVH
.. |  . || |||.|..   .||. |.|  ..    .. |...|.|      | .. ..|..|||. |.    |. || .. .|.     .| ||..||
ddnerdk.kcaryWsdkgvttfGdvsvvllsvsereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvh

CSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEF
|.|| |||| ...|| ..  |..|  ||||. |. || .|..||||.||| ||. |.||| |. .|.|..  |
claGvGrtgvlltidsvvaeakrekevdifglvkklrqerpylvqtkeqykfvyvavleallsedtriqasyf
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 907-1159 4.5e-44 145.3 In-house 28-286 (310) alignment 
Range on Protein: 907-1159
Range on HMM: 28-286/310.0
GFKEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLlVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT
|.  .|  |   | .|       ..  |||| ...  | |||.|  .|   . ||| |||.   .    .| .|||.| |. ||||||.|| . ||... 
glvkqyrkldakqdssltyeaykkymhknrysdvvcldtsrvkl.kidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllc

NLVEVGRVKCVRYWPD--DTEVYGDIKVTLIEtEPLAEYVIR----TFTVQK----KGYHEIRELR--LFHFTSWPDHGVPCYATGLlgfVRQvKFLNPP
. .| || ||| |||    || || |.|| .  |   |. |     ||  ..    .   ...|||  | ..  ||| |||         | | ..|   
kvgeegrpkcvgywpslgvtetygcirvtnls.esseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekcht...vpq.rllaqv

EAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI
  || ||||||| .|... .|..  .| ...   ||. . . ||. .|.  .||| ||....   
rhgpcvvhcsagkdrlyvvvalklkidkldrglkvdaeevktellksraiciqtelqyliidrvr
0036941 (Phosphotyrosine protein) phosphatases II 908-1179 1.5e-100 331.6 In-house 15-293 (297) alignment 
Range on Protein: 908-1179
Range on HMM: 15-293/297.0
FKEEYEALPEGQ-TASWDTAKEDENRNKNRYGNIISYDHSRVRLlvldGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT
...|.| |.. .   |...|.  ||..|||| .|. |||.||.|    .|..||||||.|.|||...|..||||||...|| |||||.|..|. .|||.|
llkefeellpllllgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmlt

NLVEVGRVKCVRYWP---DDTEVYGDIKVTLIETEP--LAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPP--EAGPI
.||| ||.|| .|||   ... .|||..|||...|   |..|..||..|...|. | |... ||.|.||||||| ... || |...|.  ..   . ||.
elvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpv

VVHCSAGAGRTGCFIAIDTMLDMAE---NEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLY
.|||||| ||.|.|||.|.||.. |    || |||...|..|| || . |||.|||.|...|.|| .....| .|.... .|.
lVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltkepllklvlll
DSPc_SM00195 908-1162 7.8e-91 299.4 In-house 2-261 (263) alignment 
Range on Protein: 908-1162
Range on HMM: 2-261/263.0
FKEEYEALPEGQ-TASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT
.|||.| | | . . . ..|....|..|||| ||. |||.||.|   .....|||||||||.|......|||||||...||.|||||.|.|..  |||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLVEVGRVKCVRYWPDD---TEVYGDIKVTLIETEPLA-EYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVH
. .| |. || ||||..   .|..|.|.|.|.|.|    |...||....|.| .| |... .....|||||||  .. .| ..|.||  .  . ||||||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEA
|||| ||||.|..||..|.  |.|  ||||..|.||| || ..|||.||| |...||||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
PTPc_SM00194 908-1162 7.8e-91 299.4 In-house 2-261 (263) alignment 
Range on Protein: 908-1162
Range on HMM: 2-261/263.0
FKEEYEALPEGQ-TASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT
.|||.| | | . . . ..|....|..|||| ||. |||.||.|   .....|||||||||.|......|||||||...||.|||||.|.|..  |||.|
lkeefekleestspketteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

NLVEVGRVKCVRYWPDD---TEVYGDIKVTLIETEPLA-EYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVH
. .| |. || ||||..   .|..|.|.|.|.|.|    |...||....|.| .| |... .....|||||||  .. .| ..|.||  .  . ||||||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEA
|||| ||||.|..||..|.  |.|  ||||..|.||| || ..|||.||| |...||||.
CsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeailey
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 908-1161 9.4e-42 137.6 In-house 13-267 (281) alignment 
Range on Protein: 908-1161
Range on HMM: 13-267/281.0
FKEEYEALPEGQTASWDTAKE-DENRNKNRYGNIISYDHSRVRLLV-LDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMV
||.|.  ||    .   |. .   | .|||| ||   | |||.| | .     .||| ||||      | || |||| .||  ||||||||||...|||.
fkqefsnlpgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttaivml

TNLVEVGRVKCVRYWPDDTEVYGDIKVTLIETEP-LAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFlnppEAGPIVVHCS
 ...|  | ||  |.| .. .  ..    .. |    .  . |  ..     | | .  . .  |||  ||  .  .|  .|...      . | |.|||
cqfletnrekcaeyfprnahcclqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwqvpessevmlkilrkira....rstppvihcs

AGAGRTGCFIAIDTMLDMAEN-EGVVDIFNCVRELRA-QRVNLVQTEEQYVFVHDAILE
|| ||.| ..|..  |.   .   . || . |  ||   |   ||| .||...   .|.
agvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlld
subfamily_ptpA1_pd Subfamily ptpA1 908-1120 1.7e-39 130.7 In-house 23-253 (418) alignment 
Range on Protein: 908-1120
Range on HMM: 23-253/418.0
FKEEYEALPEGQTASwDTAKED--ENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHrPRHYIATQGPMQETVKDFWRMIWQENSASIVMV
 |||.  | |    | .|.. |   | .|||| ||.  .|.||.|  ..    ||||||||||| . |...|.||||. .|. |||||.|..    |||.
ikeefrlleesvgps.etsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgay.pkqfictqgplpntiadfwrmvwenrcriivml

TNLVEVGRVKCVRYWPDD------------TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFV-----RQV
.   |  |.|| ||||..             ||.|   | |.|     |  | |  ..     | |..  ...  |||| .| ..  .  ..     || 
sresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfrqllhsitnrqn

KFLNPP-EAGPIVVHCSAGAGRTGCFIAIDTML
. .       ||.|||||| |||| | .   |.
qiipssdrnvpiivhcsagvgrtgtfctavimm
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 908-1162 7.6e-36 118.6 In-house 21-270 (288) alignment 
Range on Protein: 908-1162
Range on HMM: 21-270/288.0
FKEEYEALPEGQTAswDTAKE-DENRNKNRYGNIISYDHSRVRLLvldGDPHsDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT
 | ||.  |.. .   |....  .|  ..|| |.   | .||.|     ||.  ||.|| .   . .|. | .| |.. |.. .|.|. ...   |||..
lkkeyrdspneasi..diidsfianptrdryenlprcditrvkls...ddpd.fyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlc

NLVEVGRVKCVRYWPDDTEVYGDIK----VTLIETEPLaEYVIRTFTVQKKGYHEIR-ELRLFHFTSWPDHGVPCYatgLLGFVRQVKFLnPPEAGPIVV
.|.| |. |   |.|        |.    |.  . . . . ...  ... .   | .  ..  |.  |.|.|||      | ..| .. |      ||||
ellekGkeksaeyfPsklGekarigrlctvvkkkradi.dklvkvsllriskegeekvivkilhlleWdddgvPen...ylsplrllevl.kslqkPivv

HCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEA
|.|||.|||| .| |  .|...  .  . | . . .||..| . .||| ||..||  .|| 
hssaGvGrtgtlililialeslrlddflgirsllaklreerfkaiqtemqylyvhrcvlee
0045098 (Phosphotyrosine protein) phosphatases II 909-1166 2.3e-86 284.9 In-house 11-275 (278) alignment 
Range on Protein: 909-1166
Range on HMM: 11-275/278.0
KEEYEALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRllvldgdphsDYINANYIDGYhrPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNL
 | .. |. |.  .. .|   .|..|||| .|. ||||||.          |||||.|||||  |...||||||...|| |||||.|.... .|||.|.|
lefefllllgipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltel

VEVGRVKCVRYWPDDT-EVYGDIKVTLIETEPLAEYVIRTFTVQKK----GYHEIRELRLFHFTSWPDHGVPCYA--TGLLGFVRQVKFLNP--------
|| ||.||..|||..  ..|||..|||...| | .|..||..|.       . | |... .|...||||||| .   . .| ......  .         
velgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllasllls

-----PEAGPIVVHCSAGAGRTGCFIAIDTMLDMAenEGVVDIFNCVRELRAQRVN-LVQTEEQYVFVHDAILEACLCG
     .. ||..|||||| ||||...|...||..   ||.||....|.||| || .  ||..|||.|.....||  |.|
slllldsggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelllrg
subfamily_PTPN13_pd Subfamily PTPN13 909-1162 2.4e-73 241.8 In-house 14-268 (273) alignment 
Range on Protein: 909-1162
Range on HMM: 14-268/273.0
KEEYEALPEGQT-ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGdphsdYINANYIDGY--HRPRHYIATQGPMQETVKDFWRMIWQENSASIVMV
.||.. | | ..  . ...|..||..|||| |.. ||..||.|    |     ||||..|     .   .|||.|||. |||||||.|.|. ..  |.||
aeefkelrelkpldtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaeviamv

TNLVEVGRVKCVRYWPDDT----EVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPpEAGPIVV
|. .| |.||| ||||. .     |.. ..|.|.... | ..|.|...|...   | ||.  ..|..|||||||  |. || ||..|. |.  .||||||
tlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dagPivv

HCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEA
||||| ||.| .|.||..|.. |..  .|. . ||.|| ||  .|||..||.||. ||||.
hcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailev
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 909-1161 4e-46 152.2 In-house 9-257 (267) alignment 
Range on Protein: 909-1161
Range on HMM: 9-257/267.0
KEEYEALPEGQTASWD--TAKEDENRNKNRYGNIISYDHSRVRLLVLDGDphsdYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT
..|.| . .  . |    .    .|...||. . . ||..|| |   . .    |||| |..||.. ...|.||.|.. |. ||. .| ... . ||..|
ekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktknafivtqdplkntitdfltvihdqkvpvivllt

NlveVGRVKCVRYWPDD---TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGyHEIRELRLFHFTSWPD-HGVPCYATGLLGFVRQVKFLNppEAGPIVVH
.   |.  .  ..||     .. | |. |     .   .| | |. .. |     ... |...  |        |   |.| . . .. |     |.||.
k...vftdnirlfwPPkmgqakkyqdltvehslekeendyqiitlelkfkn.esahnvtlyyykkwnintnnkpylkplfgilaknqlen..gnrPlvva

CSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE
||.| ||.| |. ||..|. | .|||.|||. .|..| ||. ||.| |.|...|. . |
csdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellae
subfamily_CG42327_pd Subfamily CG42327 909-1089 4.8e-32 105.9 In-house 8-191 (319) alignment 
Range on Protein: 909-1089
Range on HMM: 8-191/319.0
KEEYEALPeGQTASWDtAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHR-PRHYIATQGPMQETVKDFWRMIWQENSASIVMVTN
 ||.. ||    |. | .     ..|.|. |..   ..|| |     |... |..|.|. ||.  | .|||.| .....  ||||..|. .|  || .|.
aeefrdlP.qliarad.evPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltd

LVEVGRVKCVRYWP-----DDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFtSWPDHGVPCYATGLLGFVRQVK
| | |  .| .|.|     |.|..||||.||| . |   .|.| |. ...   .| |||  . .  |.. .||.  . |.  . .|.
lselGikvcaeylPtketldntslyGdilvtlkgrevkdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliamllevr
subfamily_PTPRN_pd Subfamily PTPRN 910-1161 5.3e-60 197.6 In-house 33-290 (297) alignment 
Range on Protein: 910-1161
Range on HMM: 33-290/297.0
EEYEALPEG--QTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYI-DGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVT
.|.||| .   . .. ..||...| .|||. ....||||||.|     . .||||||  | |   |   |||||||. .|| |||.|.|.. .. ||..|
kewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqGvvvivnlt

NLVEVGRVKCVRYWPDD-TEVYGDIKVTLIETEPL-AEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCS
.| | |  .| |||||. .|||.  .| |.       .|..|.| ..    .| | .  ||| |||..|||  |  || | |.|       . |||||||
rleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpeegvPasaksllefrrkvnksyrGrscpivvhcs

AGAGRTGCFIAIDTMLD-MAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE
.||||||..|.|| .|. ..     .||   .  || || .||.|..|. |.  |. |
dGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavae
subfamily_PTPN12_pd Subfamily PTPN12 913-1163 8.1e-81 266.1 In-house 22-277 (290) alignment 
Range on Protein: 913-1163
Range on HMM: 22-277/290.0
EALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVG
|.. . .. | ......||..|||| .|. ||.||| |   .....|||||||.| | . . .|||.|||. .|..|||||||. |   .||. ..||.|
ekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelg

RVKCVRYWPDDT--EV-YGDIKVTLIETEPLA-EYVIRTFTVQKKgyHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAG
. || ||||. .  |. .|...|||.| . .  ...|||..|...  .| |... ||.|.|||||||  |. || ....|. |.  |. |.||||||| |
kkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvG

RTGCFIAIDTMLDMAENEGV---VDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEAC
|||  |||| . .. ..| .   .|.|. |.||| ||. ||||.|||..|. |..| .
rtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 914-1162 3.9e-68 224.3 In-house 3-263 (270) alignment 
Range on Protein: 914-1162
Range on HMM: 3-263/270.0
ALPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYH-RPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVG
 |....| . |  .   ... ||| .|.   ..||||  |. |... ||||||. |.. ....|||..||.. |.|.||||||.|.. .|||.|.|.| |
eldkeetsesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkg

RVKCVRYWPDDTEV-----YGDIKVTLIETEPLAEYVIRTFTVQKKGyhEIRELRLFHFTSWPDHGVPCYAT------GLLGFVRQVKFL-NPP-EAGPI
| || |||| ...      .|.|||. ...|    |...  ....||  |.|.|  |....|||||||  .        ||  .|.|.   .   .|.|.
rkkCerYWpaepkekvkledgkikvlalseekeegyiltrlrleekg..eerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkaePl

VVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEA
.|||||| ||||..||.|... . |... ||. . ..||| .|..|||. ||| |.. |..| 
lvHcsaGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavvey
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 915-1161 1.7e-47 156.7 In-house 17-293 (297) alignment 
Range on Protein: 915-1161
Range on HMM: 17-293/297.0
LPEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLvlDGDPHSDYINANYIDGY--HRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVG
| | .. |. .|| .    |||| .|...| .||.||   . . .|||||.|.     . . .|| .|||...||.|||.......   ||||..| | |
ldeargesfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqedG

RVKCVRYWPDDT---EVYGDIKVTLIETEP--LAEYVIRTFTVQKKgyHEIRELRLFHFTSWPDHGVP----------------CYAT-GLLGFVR----
| ||. |||.        ||. |  . .        ..  ...  .   | | .|   | ||||||||                | |   .|. |     
rdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhGvpsdledlvrfqaqvcscciavpmmlalvemfta

----QVKFLN--PPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE
    |.. |.   |   ...|||||| ||.|  .  |..|..  .. . |.   .. || ||  |||| ||. ...||.|.
mvflqleslraemprnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlk
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 917-1160 3.8e-63 208.0 In-house 24-274 (287) alignment 
Range on Protein: 917-1160
Range on HMM: 24-274/287.0
EGQTASWDTAKEDENRNKNRYGNIISYDHSRVrLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKC
|. || . .|.|  . .||||.... .|..|| ||. .|.  ||||||||. .|..   .||.|||.  ||.||||......|||....|  || .| ||
esstatfkaaeelaavkknryadvlPiddtrv.llsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkc

VRYWPDDTE--VYGDIKVTLIETEPL-AEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVK-----FLNPPEAGPIVVHCSAGAG
 .|||.       |   |.|.. . .  || .|.. . .   .| | .. ... ||||....  | ||. || .||       .  |.||.|||...|.|
ykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhielardasevGPlvvhddvGiG

RTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAIL
|.| ..|. ..... |. | ||. . |  || .|  |||.  |. .. .|. 
rsGillatlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 917-1162 3.3e-47 156.0 In-house 27-276 (307) alignment 
Range on Protein: 917-1162
Range on HMM: 27-276/307.0
EGQTASWDTAKEDENRNKNRYGNIISYDHSRVrLLVLDGDpHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKC
. .  .  .   . | .|||| ..   |..|. .. .||   |||| |||.    .|...|..|||...|. .|| |. ||.  |..|. ...|....||
kktpegvtveafsantdknryqdvkcqdkgri.vvkfdgl.asdyihanylgiaikpkkficaqgplentqysfwamaiqekvesvimlckvielakikc

VRYWPD---DTEVYGDIKV----TLIETEPLA--EYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFlnppEAGPIVVHCSAGA
 .|||    .. |.|.       . . .. ||  | .|   |.. .  .. | .. . .. |||.|||    . . ..  |..    .  |.||||||| 
eqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleavry....dtnpvvvhcsaGv

GRTGCFIAIDTMLD-MAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEA
||.|  .||  . | | . .   |. . |.|||.||   .||| ||...|  .|| 
GrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlley
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 920-1183 8.5e-86 283.1 In-house 50-311 (319) alignment 
Range on Protein: 920-1183
Range on HMM: 50-311/319.0
TASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTnlvevgRVKCVRY
 |  . |  |.|..|||..||...|...|.|  |.|   |||||| ...|| |.  |||.|||...|..|||||||. |...||..|      . || .|
ladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiweyncstivllt......kdkcsqy

WPDDTE-VYGDIKVTLIETEPLAEYVIRTFTVQKKGY-HEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAG--PIVVHCSAGAGRTGCFIA
|| ...  ..  || .   |  ||||.| . . ..|  ..||... |||  |||.||| |.. |. .|..|. |.  | .  .||||||||.|||| .|.
wplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrhltskenhranivvhcsaGvGrtGvyiv

IDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNIS
.|..||. ..|  ||..| ||.|| || .|||   || |.. |.||  | |.. . . .| . . . |
ldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvampdfpayleels
subfamily_PTPN23_pd Subfamily PTPN23 920-1162 6.6e-60 197.4 In-house 32-279 (288) alignment 
Range on Protein: 920-1162
Range on HMM: 32-279/288.0
TASWDTAKEDENRNKNRYGNIISYDHSRVRLLvldgDPHSDYINANYIDGYH-RPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVR
. .  .|    . .|||. .|. |||.|| |     . . ||||| .. .      ..||||.|.|.|. |||.|.... |  |||...  | |. |. |
arkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqkssviVmllskeelgkpkvdr

YWPD---DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKF----LNPPEAGPIVVHCSAGAGRTG
|||    .|...||..||| ... . ..| |..... .. ........ ..||||..|||     || |. .|.      . .   |.||||||| ||||
YwPedkgetvkfgdlsvtlksvretethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesayeavqrksktPlvvhCsaGvgRtg

CFIAIDT-MLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEA
 |  . . . .. ...|..|| . |. ||.|| . ||..||. |. .|.|||
vfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_egg_pd Subfamily egg 920-1160 1e-28 94.9 In-house 29-267 (307) alignment 
Range on Protein: 920-1160
Range on HMM: 29-267/307.0
TASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVgrVKCVRY
  |  || .|.|..| |   .   | |||.| .  |    |.| ||...|     ..| .| |...||.|||||..||.   |||.|  .|    .|  |
eislttaasdnnlekarskrvhckdssrvklelrrGqylddfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyy

WPD---DTEVY--GDIKVTLIETEPLAEYVIRTFTVQKKGYHeIRELRLFHFTSWPDHGVPCYATglLGFVRQVKFLnppeAGPIVVHCSAGAGRTGCFI
||    |. |.  | .... .. .  |. . |   ..  | .   |. | |.    ..    |    |  .|... |    . |.||..  |  ......
wpkaesdslvtvpGslrienlkvdskadplfrvtklklvGgd.deerflehwqgdvnnssdvysp..lrvlrklrnl....skpvvvqdilGvskaatlv

AIDTMLDMAEN--EGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAIL
||.. |            . ..|  || .|   |..  .|.||.  .|
aieiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlvl
subfamily_PTPN1_pd Subfamily PTPN1 921-1164 1e-64 213.1 In-house 22-272 (290) alignment 
Range on Protein: 921-1164
Range on HMM: 22-272/290.0
ASWDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGdphsDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYW
 .  .||..||||.||| ..  |||||..|   |     |||||. ..  .  |.|| ||||. .||. ||.|.|...| ..||. ..|| ...||..||
fptreaklpenrnlnryrdvspydhsrikleradn....dyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqyw

PDDTE---VYG---DIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVK---FLNpPEAGPIVVHCSAGAGRTG
| . |   .      .||.||..|   .|..|.. ....  .| ||.  ||.|.||| |||   . .| |. .|.    |. .. || |.||||| ||.|
PqgeeekellledtklkvkliseerksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGsls.sdvGpavihcsaGiGrsG

CFIAIDTMLDMAENEGV---VDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACL
 |. .||.|   |...    ||| . . ||| .|. |.|| .|  | . ||||   
tfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGak
subfamily_PTPN3_pd Subfamily PTPN3 922-1162 4.7e-74 243.8 In-house 32-274 (280) alignment 
Range on Protein: 922-1162
Range on HMM: 32-274/280.0
SWDTAKEDENRNKNRYGNIISYDHSRVRLLvldGDPHsDYINANYID----GYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCV
. ..|.  || .|||| .|..||. ||.|      .  |||||||..    . .   .|||||||...|..|||.|.|...|  |||.|.||| ||||| 
aisaarkpenlsknryrdilpydatrvklk...eset.dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlverGrvkCh

RYWPDDT--EVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIA
.|||. .    ||...|.. ...   .||.| .....|  .| |..  . ...|||||||  .. .| ||..|. |   .  |.||||||| |||| .|.
qyWPetedeleygefsvkcekedetksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGigrtGvlil

IDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEA
..| | . |..  | . . ||..| || .||||..|| || .|||..
letalalieaaepvypldivrtmrdqramlvqtasqykfvCeailkv
0040439 (Phosphotyrosine protein) phosphatases II 923-1164 5.4e-89 293.3 In-house 3-247 (249) alignment 
Range on Protein: 923-1164
Range on HMM: 3-247/249.0
WDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP-
...|.  ||..|||| .|. ||||||.| .|.| ..||||||.|||||...|..||||||..|||.|||||.|.... .|||.|.||| ||.|| .||| 
ysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

DDTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNP--PEAGPIVVHCSAGAGRTGCFIAIDTM
... .|||..|||...| ...|..||........ | |. . ...|.||||||| .   || |...|.  .   |. ||..|||||| ||||.|||...|
ggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylm

LDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACL
|.. | |. ||....|..|| || . ||..|||.|...|.|| .|
leqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallelll
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 923-1183 1.1e-84 279.4 In-house 17-275 (284) alignment 
Range on Protein: 923-1183
Range on HMM: 17-275/284.0
WDTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTnlvevgRVKCVRYWPD
   |  |.|..|||.|.|...|...|.|  |.|   |||||| .| || |.  |||||||...|..|||||||. |...||..|      . || .||| 
qtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt......kdkcsqywpl

DTE-VYGDIKVTLIETEPLAEYVIRTFTVQKKGY-HEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAG--PIVVHCSAGAGRTGCFIAIDT
...  ..  || .   |  .|||.| . . ..|  ..||..| |||  |||.||| |.. |. .|..|. |.  | .  .||||||||.|||| .|..|.
kivikeerfkvkvdsveeseeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvhcsagvgrtgvyivldv

MLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRSLYYNIS
.||. ..|  ||..| ||.|| || .|||   || |.. |.||  | |.. . . .| . . . |
lldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalleehlfghsdvalpdfpayleels
0037934 (Phosphotyrosine protein) phosphatases II 923-1161 2.5e-80 264.8 In-house 2-240 (243) alignment 
Range on Protein: 923-1161
Range on HMM: 2-240/243.0
WDTAKEDENRNKNRYGNIISYDHSRVRLlvldgDPhSDYINANYIDGYhrPrHYIATQGPMQETVKD----FWRMIWQENSASIVMVTNLVEVGRVKCVR
. .|.  ||..|||| .|. ||||||.|     .. |||||||.|...  | ..||||||..|||.|    ||||.|.... .|||.|.||| ||.||..
fsiallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvt..p.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPDDTeVYGDIKVTLIETEPLAEYVIRTFTVQKKG-YHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFL--------NPPEAGPIVVHCSAGAGR
|||... .|||..|||...| |..|..||.... .. ... |. . .|...|||||||   . || |...|.          . .. ||..|||||| ||
ywpgev.tygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgR

TGCFIAIDTMLDMAeneGvVDIFNCVRELRAQRVN-LVQTEEQYVFVHDAILE
||..||...||..    | ||....|..||.|| .  |||..||.|...|.||
tGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyealle
0049772 (Phosphotyrosine protein) phosphatases II 923-1164 6.3e-43 143.0 In-house 38-281 (314) alignment 
Range on Protein: 923-1164
Range on HMM: 38-281/314.0
WDTAKEDENRNKNRYGNIISYDhSRVRLLVLDGDPhSDYINANYIDGYhrpRHYIATQGPMQETVKDF----------WRMI--WQENSASIVM------
. .|.  .||.|||| .|. .| .||.|  |...  ||||||.|.||.   . .||||||...|| ||          |||.  .. |.  |||      
ilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf...lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevl

---------------VTNLVEVGrvkcvR-----YWPDDTevygdikvtlieteplaeyvirtfTVQKKGYHEIRELRLFHFTSWPDHGVPcYATGLLGF
                ..| . |           ....                          ...  . .  |.   .. . .||...|     .. |
adelsrLdaAlgKtpllildgng.....neptaadlellk........................eelydpelferlgikylripvpDgsap.lledfdef

VRQVKFLnpPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAeneGVvDIFNCVRELRAQRV-----NLVQTEEQYVFVHDAILEACL
.. .. .  .. ||..|||.|| ||||.|.... ..      || ..  .....|..|      ..... |||.|...|.||.. 
lefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll...gv.sleealedvrlkRpinpnpgfieqleqyefilealleylk
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 923-1163 3.9e-42 139.1 In-house 40-287 (305) alignment 
Range on Protein: 923-1163
Range on HMM: 40-287/305.0
WDTAKEDENRNKNRYGNIISYDHSRVRLlvlDG-DPHsDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP
  . || ....|||| ..   |. ||.|   .|  || .|| |||.     |. .| || |...|  ||| | .|..  .| |. ||.| |  ||. |..
mkafkeaqeagknrykdvgcldnnrvkl...egpwph.eyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfa

DDTE-V--Y--GDIKVTL-IET-------EPLAEYVIRT-FTVQKKGyHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKflnpPEAGPIVVHCSAGA
 . . |  .  .. |... .|.       .. .  | .| ....  | .. |    .|.  ||| |||.  . .| .. . .    |  |||||||||| 
skdkdvlefeekgqkisvkfessvtlkfrkdakakvtetvlviegpg.ekarkvthyhwidwpdrgvpaadlailellekar....pskgpivvhcsagi

GRTGCFIAIDTMLDMAENEGVV-DIFNCVRELRAQRVNLVQTEEQYVFVHDAILEAC
||||  . .. .||   .  .. |    .. .| || | .||..||.|||. ||. .
grtgsvvmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
0042113 (Phosphotyrosine protein) phosphatases II 924-1161 3.8e-88 290.3 In-house 2-241 (245) alignment 
Range on Protein: 924-1161
Range on HMM: 2-241/245.0
DTAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP-D
..|.  ||..|||| .|. |||.||.| . .||..||||||.|.|||......||||||..|||.|||||.|.... .|||.|...| ||||| .||| .
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

DTEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNP-PEAGPIVVHCSAGAGRTGCFIAIDTMLD
.. .|||..|||...| |..|..||..|...|..| || . .|...||||||| .   || |.. |.     .. ||..|||||| ||||.|||...||.
esltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

MAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE
..| |. |.....|.||| || . |||..||.|...|.||
qlekelgvsleeavkelrsqRpgavqtpsqyrflyealle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 924-1177 2.1e-62 205.6 In-house 26-280 (283) alignment 
Range on Protein: 924-1177
Range on HMM: 26-280/283.0
DTAKEDENRNKNRYGNIISYDHSRVRLLVLDGdphsDYINANYID---GYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYW
| |  |||..|||. .|...|  ||.|  .      ||||| .|     |.. . ||..|.|...||.|||.|...|. ..|||.|.| |  |.|| .||
diasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsqyW

PDD-TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRE-LRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDT
| . .| ||.  ||| .      ..|. .......  .    |  . .  | . |       |. | . .   .  . ||||||||.| |||. |||. .
PkrGsedyGeftvtlrkettsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfiaasa

MLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIPVCEFRS
 .. |  | |||.|. |. .| ||. .||| .|| .||...|| .|||.| |  ... |
svkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvleqalcgdtqiaavdlqs
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 925-1165 3.4e-92 303.2 In-house 3-244 (250) alignment 
Range on Protein: 925-1165
Range on HMM: 3-244/250.0
TAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVkCVRYWP-DD
 ||. .|..|||| .||..|.||| |   .|| .|||||| ...||.  . .||||||.|.|..|||||...|.|..|||.|||.| ... . .||| . 
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPvek

TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPP-EAGPIVVHCSAGAGRTGCFIAIDTMLDM
.| |||..|.| ..|  |.|..|.. . |.   . | .| .||..||| ||| .||  |.....|.  ..  ...|..|.|||| ||.|.|||||..|. 
aekyGdvtvsllskeefadytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

AENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLC
...| |||.|. .. ||..|.. |...||||||. .||.|  .
lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkalds
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 925-1161 2.3e-82 270.7 In-house 2-239 (239) alignment 
Range on Protein: 925-1161
Range on HMM: 2-239/239.0
TAKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYH-RPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD
.||.  |. |||| ||..|||||| |  |  |||||||||.|.  |   |. |||||| .. .  |||||.|||  . |||.| |.|  . || .|||| 
aakkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds

TEVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMA
|  | ...||| .|| .|.|.|||| . . |  | | .  .||| |||.||| ||| .||. |..   . | | | |.||||| ||||.|. ||.||  |
tskycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqa

ENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE
...  ||||| |. .| .|  .||| |||||.| |.||
kkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 926-1162 9.6e-83 272.0 In-house 2-239 (239) alignment 
Range on Protein: 926-1162
Range on HMM: 2-239/239.0
AKEDENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINANYIDGYH-RPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDT
||.  |. |||| ||..|||||| |  |  |||||||||.|.  |   |. |||||| .. .  |||||.|||  . |||.| |.|  . || .|||| |
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

EVYGDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAE
  | ...||| .|| .|.|.|||| . . |  | | .  .||| |||.||| ||| .||. |..   . | | | |.||||| ||||.|. ||.||  |.
skycnlrvtlrktevfadyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrqak

NEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEA
..  ||||| |. .| .|  .||| |||||.| |.|||
kqktvdifnyvkairedrphmvqtseqyvfihlavlea
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 926-1160 2.9e-73 241.3 In-house 23-265 (274) alignment 
Range on Protein: 926-1160
Range on HMM: 23-265/274.0
AKEDENRNKNRYGNIISYDHSRVRLLVLDG-DPHSDYINANYIDGYHR-PRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDD
 .   . .|||| .|.  ..||| |   .. |. |.||||||| ||..  . |.|||||...||.||||||.||..  |||.|.| |  . ||..|.||.
ldvfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPda

TEV-----YGDIKVTLIETEPLAEYVIRTFTVQKKGYheIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNP---PEAGPIVVHCSAGAGRTGCFIA
...     |||....  ..    .| .|......      |..  . .|.|||| .|  |. || .|..|.  .     ...|.||||||| ||||||||
edyeiserygdveikvekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfia

IDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAIL
|.  .   ..|.|||... | .|| .|  .|||.||| ..| |. 
isiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralc
subfamily_eak_pd Subfamily eak 926-1078 3.6e-14 46.9 In-house 47-198 (332) alignment 
Range on Protein: 926-1078
Range on HMM: 47-198/332.0
AKEDENRNKNrYGNIISYDHSRVRLLVLDGDPhSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDT-
..  |. |.|   .|. ||.  |||     ..   ||||  ..  .  |.|| |  . .. |  ||.|. ...| .||.. . || .  |  .|.||.| 
tarleavnrn.vvkivpydrylvrltssqlnr.lGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktr

E--VYGDIKVTLIETEPLAEYVIRTFTVQKkGyHEIRELRLFHFTSWPDHGVPCYA
|   .| ..|.  |    . .  | . ..| |  |  ..  ...  | .  .| | 
eelkfGildverkefvkrniletrllelsk.G.nethrvlhykvfGwtettlpkye
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 926-1074 1.2e-13 45.3 In-house 91-235 (244) alignment 
Range on Protein: 926-1074
Range on HMM: 91-235/244.0
AKEDENRNKNRYGNIISYDHSRVRLlvLDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVmVTNLVEvgrvKCVRYWPDDT-
| . .|  ||| |  . .| .|| |    |     |||| ..    |   || || |. .|  |||.|. .     .| |   ||    .   ||||   
afnpnnswknregaglpfdfnrvpl..skgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlv.vlgsve....eedeywpdsep

-EVY-GDIKVTLIETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGV
 | |  || ||| . . . .     . ..       . | .|  . ||  | 
lewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgt
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 928-1162 3.7e-41 135.7 In-house 52-288 (305) alignment 
Range on Protein: 928-1162
Range on HMM: 52-288/305.0
EDENRNKNRYGNIISYDHSRVRllvLDGDPHSDYINANYIDGYHRP-RHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDT--
 | .  |||| ..   |.| |.   ||  . |||| |||.     | . .|..|||...|. .|| |. |..   |||. . ||.|..|| .|||     
adiaitknryqdvpcqdqsavk...ldkpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqge

--EVYGDIKVTLI-ETEPLA---EYVIRTFTVQKKGYHEiRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFlnppEAGPIVVHCSAGAGRTGCFIAIDT
  |. . | |  .  . |.    |  | .. .   | ..   .| ...| ||| |||      | ..  ..        ||||||||| ||||  .||. 
klelksgivvenvsgskpmerdaeiqitllnltysgdqk.msvrhlqwtewpdrgvppckltslellsairg....skvpivvhcsagigrtgtivaiey

MLD-MAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEA
.|. .|||  .  . . |. || ||   .|.. ||.|.|  .|. 
ilekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlny
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 929-1161 7.9e-51 167.4 In-house 52-281 (290) alignment 
Range on Protein: 929-1161
Range on HMM: 52-281/290.0
DENR--NKNRYGNIISYDHSRVrlLVLDGDPhSDYINANYIDGYHRPrhYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDT--
|.|   .|||| ...  | .||  .. || .  ||. |||..| . .  .| |||....|| |.|||. ||. | |||. .|.| |. || .|.|.    
dkntefkknrykdvvcndktrv..ilkdGyd.GdyvhanyvkGlkam..filtqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe

-EVYGDIKVTL-IETEPLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLnppeAGPIVVHCSAGAGRTGCFIAIDTMLDM
   .|.| |.   |... |. . .|..|..|       |. ..  ||||. |.  .  ||  .| .. .    .||.||||||| |||| |.||.. |..
vltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlrilrka....sGpvvvhcsaGiGrtGtfvaievglqi

AENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE
  .   .|. . || ||  |.| || . ||. . ...|.
lldGkeldlldlvralrnsrlnsvqvdiqylalveilld
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 929-1162 1.8e-36 120.5 In-house 33-269 (285) alignment 
Range on Protein: 929-1162
Range on HMM: 33-269/285.0
DENRNKNRYGNIISYDHSRVRLLVLDgdphSDYINANYIDGYHR-PRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDT-EV
. | . ||| ..   . .|| |   |     ||| |...    .    ||.||||. ||. |||.||.||. | ..|.  |.| |  ||  |.|.   ||
eanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcalyypeklgev

--YGDIKVTLIET--EPLAEYVIRTFTVQKKGYHEIRELRLFHF--TSWPDHGVPCYATGLLGFVRQVKFLNPPEAgPIVVHCSAGAGRTGCFIAIDTM-
  .|  ..|| |   | .|  .. ..|| .        | . |     |||.  |  |  .. . . || .|| |  ||.|||||| |||  |. ||   
vkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkvnpkek.picvhcsagvgrtatfvgidyat

LDMAENeGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEA
. . ||   ..... |||.|| |.. ||.  |..|..  ..| 
irimen.pniemldivremramrfqavqshmqflflyvvlmey
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 929-1005 3e-08 27.6 In-house 35-116 (347) alignment 
Range on Protein: 929-1005
Range on HMM: 35-116/347.0
DENRNKNRYGNIISYDHSRVRLLV-----LDGDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMV
. . .|||  .    | .|| |          |.   |||| .|      ..|| || |. .||.|||.|.   . . .| .
ekslsknrskdvklidatrvvlspeksknsraddvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvti
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 930-1161 3.9e-72 237.3 In-house 2-237 (237) alignment 
Range on Protein: 930-1161
Range on HMM: 2-237/237.0
ENRNKNRYGNIISYDHSRVRLLVLDGDphSDYINANYIDGYH-RPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD--DTEV
||. |||||||..|||||| |    ..  ||||||.|..|.   |..|||.|||.. . .|||.|.|||. . |||.| |.|  ..|| .|||.  . . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YGDIKVTLIETEPLAEYVIRTFTVQKKG-YHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNP--PEAGPIVVHCSAGAGRTGCFIAIDTMLDMA
|| . |.|   | ...| .|.....|..  .|.| .  ..||||||.||| ... || | ...   .|  .|.|| ..||||| |||| |. ||.||  |
ygvltvslkkkeefsdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidamlrqa

ENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE
... ||||.| |  .  .|  ..||..||||.|..|||
kekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 930-1164 6.7e-20 65.9 In-house 46-280 (303) alignment 
Range on Protein: 930-1164
Range on HMM: 46-280/303.0
ENRNKNRYGNIISYDHSRVRLlvldgdPHSDYINANYIDGyHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEV--Y
.| .|||. ..|  |||.|.|        | || |.|..  .  .. | || |.. |  |||.|| ...   ....    |  ..     .| . .   .
knmdknrfvdvicldhskvkl......sdssyihasylel.dsskkailtqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

GD--IKVTLI-ETEPLAEYVIRTFTVQKKGYHEIreLRLFHFTSWPDHGVPCYatGLLGFVRQVKFL-----NPPEAGPIVVHCSAGAGRTGCFIAIDTM
 .  |.|  . . |    .|..  .| .  |. .  | . |. .||   .|.   |   ||.|.  |     .  .. | |    .| ||.| |  ..| 
eersirvgefkrvelgdgwvlkvlsvsngdyksf..lhvhhykawphnsipsd..gspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfalfeta

-LDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACL
 | . ...  .|. .|.  .|  |.  ||   |. .|.  . |  |
hlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehvl
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 930-1159 9.1e-19 62.0 In-house 50-281 (302) alignment 
Range on Protein: 930-1159
Range on HMM: 50-281/302.0
ENRNKNRYGNIISYDHSRVRLlvldGDPHSDYINANYIDGYHRPRHYIATQGPMQETV---KDFWRMIWQENSASIVMVTNLVEVGRvKCVRYWPDDTEV
.| .||.  ..  .|. .|.|    .    .|.||  ..  .  |  | .| | ....    .||||..||. .|.|..    |. .     ..|  .. 
knlkknqsedvpildsnlvkl....eaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqekivsvvilvgeeelkk.tlselfpkksgd

Y---GDIKVTLIETEPLAEYViR--TFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLD
|   |.. |     |   | .    .  |  .|. .     . ..| |... ||   . |   . .|  .. .   ..|.    |||| | |..  . ..
ykeygkmfvNnrkVekaeeek.tryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikadentvivSknGaGRagafltlavave

MAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAI
  ...  . | . |. .|.|| . |.. .|||... |.
klqkgkepnikeivksiRsqRpravdslkQyvslyial
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 930-1007 2.1e-10 34.6 In-house 33-109 (332) alignment 
Range on Protein: 930-1007
Range on HMM: 33-109/332.0
ENRNKNRYGNIISYDHSRVRLLVLDGdpHSDYINANYIDGYHRPRHYIATQGPMQE-TVKDFWRMIWQENSASIVMVTN
.| . ||   .  .||||| |   ||  . |. ||...||| .   || .| |... |   ||||. . . . |... .
nnmdmnriphlycfdhsrvelapqdg..kddfynaswvdgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 930-1076 1e-06 21.8 In-house 26-156 (169) alignment 
Range on Protein: 930-1076
Range on HMM: 26-156/169.0
ENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINAnyidgyhrprhyiatqgpmqetvkdfwRMIWQENSASIVMVTNLVEvgrvkCVRYWPDDTEVYGD
 |  |||    ..  | ||.|  .  |  ||||||                           ||||. |.. ||.. .  .        .||.  .    
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlgdtdd.....knnfwpekedyqlh

IKVTLIETEPLAEYViRTFTVQKK--G-------------YH-EIR-ELRLFHFTSWPDHGVPC
  | | |    . || ||  |...  |             |. ..  .|.|.|...||. ||| 
pavilgewytdslyv.rtdkvhantsgveglfevsmvihsydddvteklsllhystwpqngvpq
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 930-1075 2.6e-06 20.4 In-house 25-154 (169) alignment 
Range on Protein: 930-1075
Range on HMM: 25-154/169.0
ENRNKNRYGNIISYDHSRVRLLVLDGDPHSDYINAnyidgyhrprhyiatqgpmqetvkdfwRMIWQENSASIVMVTNLVEvgrvkCVRYWPDDTEVYGD
 |  |||    ..  | ||.|  .  |  ||||||                           ||||. |.. ||.. .  .        .||.  .    
cnetknrpagplapshtrvklqrvmedlgsdyina...........................rmiwetnasvivvlGdtdd.....knnfwpekedyqlh

IKVTLIETEPLAEYViRTFTVQ----------------KKGYHEIRE-LRLFHFTSWPDHGVP
  | | |    . || ||  |.                ..  ... | |.|.|...||. |||
pavilGewytdslyv.rtdkvhpntsgveglfevslvihsydddvteqlsllhystwpqngvp
Y_phosphatase Protein-tyrosine phosphatase 931-1161 2.4e-88 290.9 Pfam-A 1-235 (235) alignment 
Range on Protein: 931-1161
Range on HMM: 1-235/235.0
NRNKNRYGNIISYDHSRVRLlvlDGDPH-SDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP---DDTEV
|..|||| .|. ||..||.|   .|... ||||||||..||......||||||...|..|||||.|||.. .|||.|.|.| ||.|| .|||   .... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGDIKVTLI-ETE-PLAEYVIRTFTVQKKGYH-EIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMA
||||||.|  ...   .||..|.....||. . | ||.. .|.|.|||||||  ...|| ..|.|.  . .. ||.|||||||.||||.|.|.|..|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

ENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE
|.|. ||....|.|||.|| ..||..|||.|...||||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 931-1161 2.4e-88 290.9 In-house 1-235 (235) alignment 
Range on Protein: 931-1161
Range on HMM: 1-235/235.0
NRNKNRYGNIISYDHSRVRLlvlDGDPH-SDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP---DDTEV
|..|||| .|. ||..||.|   .|... ||||||||..||......||||||...|..|||||.|||.. .|||.|.|.| ||.|| .|||   .... 
nkkknRykdilpydktrvkl...kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YGDIKVTLI-ETE-PLAEYVIRTFTVQKKGYH-EIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMA
||||||.|  ...   .||..|.....||. . | ||.. .|.|.|||||||  ...|| ..|.|.  . .. ||.|||||||.||||.|.|.|..|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

ENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE
|.|. ||....|.|||.|| ..||..|||.|...||||
eaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
0041856 (Phosphotyrosine protein) phosphatases II 931-1171 4.5e-55 181.4 In-house 1-179 (182) alignment 
Range on Protein: 931-1171
Range on HMM: 1-179/182.0
NRNKNRYGNIISYDHSRvrllvldgdpHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTnlvevgrvkCVRYWPDDTevygdi
|..|||| .|. |||||          ..||||||...|.......||||||...|| ||.||.....  .||..|         ...|||..       
nldknrysdilpydhsr..........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.........eelywpell......

kvtlieteplaeyvirtftvqkkgyheIRELRLFHFTSWPDHGVPCyATGLLGFVRQVKFlnppEAGPIVVHCSAGAGRTGCFIAIDTMLDMaeneGvVD
                            |.   .....|||||||     || |...|.     | ||..|||||| ||||...|.. |. .    | |.
...........................erlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl....g.vs

IFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLCGNTAIP
....|...| .| . |.|..||.|...|.|| .|...| ..
leeavklvrsrRpgmvitpnqyfflqlallellllkktrpk
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 931-1034 1.6e-25 84.6 In-house 47-162 (350) alignment 
Range on Protein: 931-1034
Range on HMM: 47-162/350.0
NRNKNRYGNIISYDHSRVRLL----VLDGDPH----SDYINANYIDGY-----HRPRH-YIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKC
   |||| ||. |.||||.|       |.  |    .|||||||.          | . |||||.|...||.||...| . .   |...|..|| .. ||
lfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekc

VRYWPDDTevYGDIKVTL
 |||.. .  | ||.| |
yrYWqegs..ydditvkl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 932-1155 8.6e-32 105.1 In-house 51-273 (301) alignment 
Range on Protein: 932-1155
Range on HMM: 51-273/301.0
RNKNRYGNIISYDHSRVRLLVlDGDphSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGDI-
..|.|| ..    .. |...| ||      | ||.|.   .|...||||||...| .||| |. | .   |||... ||    ||  | | ...   || 
kdkhryptvPckPstaveviv.dGk..rvPihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldig

--KVTLIETEPLAEY--VIRTFTVQK-KGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKflnpPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAEN
  |... ..| . .   . ||. |.   |  . | .  . ...|.|.|||   . |  ..  ||        ||||||||| ||. .||. . .    |.
rfkikiknkelilnkkiskrtlevedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvk....ksekPivvhcsaGiGrsvafigteylarevea

EGVVDIFNCVRELRAQRVNLVQTEEQYVFV
.  ... . ...|| .| | |||..|  ..
dptieltealkhlrehrwngvqtnsqlywm
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 932-1162 5e-30 99.3 In-house 44-275 (312) alignment 
Range on Protein: 932-1162
Range on HMM: 44-275/312.0
RNKNRYGNIISYDHSRVrllVLDGDpHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD--------D
.. ||| ||  .|  |     | ||    || ||..    .| ....||||...|.  ||..     |.||.... .|| |  ||..|  |        |
kdlnrypniqcwdrgrf...tlagd.enfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdled

TEVYGDIkVTLIETEPLAE--YVIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFlnppEAGPIVVHCSAGAGRTGCFIAIDTMLD
  || .  .| ||    .      | . |  |   .   |  . ..||||||.|      | ..  ||     .  |.. ||||| |||| .. |..|. 
hrvytey.cteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlaliesmia

MA---ENEGVVDIFNCVRElraQRVNLVQTEEQYVFVHDAILEA
      .. | |.|  .|    .|   |..  |||..  ..|| 
alrhprkqnvkdsfvllrk...drarsvrvfpqyvyalrcvlef
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 932-1036 1.7e-14 47.9 In-house 49-167 (349) alignment 
Range on Protein: 932-1036
Range on HMM: 49-167/349.0
RNKNRYGNIISYDHSRVRLLVL--------------DGDPHSDYINANYID--GYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVK
  |||| .|. |.||||.|                 |.    |||||||.    .   ..||||| |.  ||.||...|  ..   .. ...  | .  |
faknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslek

CVRYWPDDTevYGDIKVTLIE
| .|| . .  | .|.| | .
cdiywqels..ysnitvklqn
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 942-1074 2.3e-09 31.6 In-house 4-126 (130) alignment 
Range on Protein: 942-1074
Range on HMM: 4-126/130.0
SYDHSRVRllvldgdpHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQEnSASIVMVTNLVEvgrvKCVRYWPDDTEVY---GDIKVTLIETE
 .. ||..          .||||...    | . |. || |. .|  |||.|. .     ...|   ||    .   ||||   .     || ||| . .
efevsrlq........gntyinasfvGllgrtaeylltqhpladtsmdfwkmmler.yvnvlvvlgsve....eedeywpdsePlewyeediivtltdrd

PLAEYVIRTFTVQKKGYHEIRELRLFHFTSWPDHGV
   .     . ....  .  . | .|. . ||  | 
efknikasnleiesdlneshqaltmfqisnwpsdgt
0044763 (Phosphotyrosine protein) phosphatases II 943-1161 3.6e-37 123.1 In-house 2-169 (178) alignment 
Range on Protein: 943-1161
Range on HMM: 2-169/178.0
YDHSRVRLLVLDGDPHSDYINANYIDGYhrprHYIATQGPmqetvKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEvygdikvtlieteplae
.|..|| |  | | . ||||||..|...     |.....|      |.........  .||..|. .| |..|| .|||....                 
ldrtrvllsnleglersdyinaseilpg....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag.................

yvirtftvqkkgyheirelRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMaeneGVvDIFNCVRELRAQR
                     .... .||||||     .| ||. .. . ... ||..|||||| ||.|...|.. |. .    |. .........|..|
...................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl....gl.sleeaielvrerR

VnLVQTEEQYVFVHDAILE
   |....|. ....  |.
p.ivpnpgqlrqLyefelr
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 945-1160 2.4e-19 64.6 In-house 32-256 (290) alignment 
Range on Protein: 945-1160
Range on HMM: 32-256/290.0
HSRVRLLVLDGDPHSDYINANYIDgYHRPRHYIATQGPMQET-------VKDFWRMIWQENSASIVMVTNLVEVGRV----KCVRYWPDDTE---VYGDI
..|| | .      .||| ||..  .    . |.|| | ...       ...|| |. ||.. ..||. .  |  .      | .| |.  .    ....
atrvvLkgygkrfnddyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgl

KVTLIETEPLAEYVIRTFTVQkkgYHEIRELRLFH--FTSWPDHGVPCYATGLLGFVRQVKflnpPEAGPIVVHCSAGAGRTGCFIAIDTMLDM-AENEG
.|   . |   .  .|. .|.   . . .|. . |  . .| .  |.     ||  ...||     .  |..|||  |  |  .. ||.    . || .|
tvkCkskekeddvetRelvvk...fddeeeftvtHsllkgWnklnvqedtktllsliqkvk....asktpvivHcvdGiSrsAalaaiilgyQkiaetsg

VVDIFNCVRELRAQRVNLVQTEEQYVFVHDAIL
 | . . . .|| || ......... ||  .|.
svkledvlkalrkqralaitsalelafvdagiv
0046846 (Phosphotyrosine protein) phosphatases II 949-1160 2.9e-46 152.7 In-house 2-170 (176) alignment 
Range on Protein: 949-1160
Range on HMM: 2-170/176.0
RLLVLDGDPHSDYINANYIDGYhrprHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTEVYGdikvtlieteplaeyvirtf
||..|  |...||||||.|.|.    ..||||||. .|. ||..|.....   .|..|..|| ||.|| .|||. ...                      
rlrllgldldldyinanlilgs....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi....................

tvqkkgyheirelrLFHFTSWPDHGVPCYaTGLLGFVRQVKFLNPPEaGPIVVHCSAGAGRTGCFIAIDtmldMAENEGVVDIFNCVRELRAQRV-NLVQ
               .... ||||||| . . || ......       ||..|||||| ||||...|..    . | |  ..........|.||  . ||
..............qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaay....llelekglsveealalvreqRplgavq

TEEQYVFVHDAIL
|.||| |.....|
tpeQyrflyefel
0043147 (Phosphotyrosine protein) phosphatases II 955-1156 2.2e-46 153.0 In-house 1-154 (172) alignment 
Range on Protein: 955-1156
Range on HMM: 1-154/172.0
GDPHSDYINANYIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLvevgrvkcvrywpddtevygdikvtlieteplaeyvirtftvQKKG
||..||||||.|.|.|. |...||||||...|. |||||.....   ||..|.|                                          .. .
gdegsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel..........................................lydp

YHEIRELRLFHFTSWPDHGVPcYATGLLGFVRQVKF-LNPPEAGPIVVHCSAGAGRTGCFIAIDTMLdmaeneG-VvDIFNCVRELRAQRVNLVQTEEQY
... |.   .....|||||||  .  || |.....  |.  . ||..|||||| ||||...|.. ||        . .....|...|..| . ||...||
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml......lgl.sleeavalvrekRpgavqnpsqy

VFVH
 |..
rfly
0051429 (Phosphotyrosine protein) phosphatases II 957-1162 2.6e-57 189.8 In-house 2-224 (272) alignment 
Range on Protein: 957-1162
Range on HMM: 2-224/272.0
PHSDYINANYIDGYHR---PRHYIATQGPMQETVKDFWRMiWQENSASIVMVTNLVEVGRVKCVRYWP-------------DDTEVYGDIKVTLIETEPL
| |.||||....||.|   |. .....||.. |..||||. ....  .||......|.||.|| ||||             . |  ||.. |||...| |
plsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseell

AEYVIRTFTVQKK-GYHEIRELRLFHFTSWPDHGVPCYAtgLLGFVRQVKFlnppeAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVD--------I
  |..|.... .. ...|.||....|.|.|||||||  |  || .....        ||..|||||| .|||...|.. .|   . | .||        .
ldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvallllllgvsletivddYlltnlyl

FNCVRELRAQRVNLVQTEEQYVFVHDAILEA
...|.|||||| . |||||||.|...|.||.
eeaveelraqrpgavqteeqylflyeallel
0051082 (Phosphotyrosine protein) phosphatases II 957-1160 6.9e-37 121.7 In-house 1-150 (151) alignment 
Range on Protein: 957-1160
Range on HMM: 1-150/151.0
PHSDYINANYIDGYhrprhYIATQGPMQetvkDFWRMIWQENSASIVMVTNLVEVGrvKCVRYWPDDTevygdikvtlieteplaeyvirtftvqkkgyh
|.|||||..|..|.     .....||..    ||........  .||......| |  .| .|.|.                                  
plsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

eiRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFlnpPEAGPIVVHCSAGAGRTGCFIAIDTMLDMaenegvVDIFNCVRELRAQRVNLVQTEEQYVFVH
  .|.. .....|||.|.| .   .| |....     .. ||..|||||| ||||...|.. || .      |... ...|.|..| ..||...|..|..
..ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqflfql

DAIL
 |.|
fall
0036282 (Phosphotyrosine protein) phosphatases II 959-1157 9.3e-51 167.3 In-house 2-164 (174) alignment 
Range on Protein: 959-1157
Range on HMM: 2-164/174.0
SDYINANYIDGYHRPRHYIATQGPMQetvkdFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDdtevygdikvtlieteplaeyvirtftvqkKGYHEI
||||||...|........||.|||..     ||.|...... ..||.....| |..|| .|||.                              . ... 
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe..............................lredle

RELRLFHFTSWPDHGVPCYATgLLGFVRQVKFLNPP-EAGPIVVHCSAGAGRTGCFIAIDTMLDMAEnEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHD
|.   .... |||||||  .. || ||..|.      . ||..|||||| ||||...|.. || . . |..||... ||||| || . |||..|| |...
rlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQyrflyy
0049260 (Phosphotyrosine protein) phosphatases II 966-1157 1.7e-42 140.0 In-house 1-144 (152) alignment 
Range on Protein: 966-1157
Range on HMM: 1-144/152.0
YIDGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWpddtevygdikvtlieteplaeyvirtftvqkkgyheirelrLFH
.||||..|...||||||. .|..|||||... .   |||.|.|.| |..|| .|.                                           ..
fidgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..........................................qyl

FTSWPDHGVPCYATGLLGFVRQVKFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLdmaeneGVVDIFNCVRELRAQRVNLVQTEEQYVFVHD
.. |||||||  .  || ... ...|.  . ||..|||||| ||||...|.. ||        |.....|. .|..| . |....|. |...
hlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 968-1061 4.9e-10 33.3 In-house 230-323 (440) alignment 
Range on Protein: 968-1061
Range on HMM: 230-323/440.0
DGYHRPRHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEvgrVKCVRYWPDDTE--VYGDIKVTLIETEPLAEYVIRTFTVQ-KKGYHEIREL
.|| .   .|||| |.. || ||||.. . . ..|.|. .| .     |  ||| .|    .| . |    .| .    .||. .. |.  ||||..
egyskknafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntrsvtfgpftvghkgsenmnrvkvrtlelkykeevheirqf
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 974-1156 7.5e-27 88.8 In-house 5-197 (199) alignment 
Range on Protein: 974-1156
Range on HMM: 5-197/199.0
RHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD---DTEVYGDIKVTLIETEPLAEYVIRTF--TVQKKGYHEIRELRLFHFTS
|.||||| |..||. |||.|.|.  |  |||| .      .    |||     |  || . ||       ..|.| ..  | .       ||.  . |||
rryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPCYATgLLGFV---RQV-KFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAEN--EGVVDIFNCVRELRAQRVNLVQTEEQYVFVH
| ..  |  |  ..|||   |.| |  .     |..|||| | | || |.|.|  .   |.    |||.|.  . ||  |. .. . ..| |..
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 974-1156 8.3e-27 88.6 In-house 4-196 (198) alignment 
Range on Protein: 974-1156
Range on HMM: 4-196/198.0
RHYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD---DTEVYGDIKVTLIETEPLAEYVIRTF--TVQKKGYHEIRELRLFHFTS
|.||||| |..||. |||.|.|.  |  |||| .      .    |||     |  || . ||       ..|.| ..  | .       ||.  . |||
rryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqfts

WPDHGVPCYATgLLGFV---RQV-KFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAEN--EGVVDIFNCVRELRAQRVNLVQTEEQYVFVH
| ..  |  |  ..|||   |.| |  .     |..|||| | | || |.|.|  .   |.    |||.|.  . ||  |. .. . ..| |..
wkekttpnval.fvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiy
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 980-1156 5.7e-20 66.0 In-house 97-281 (302) alignment 
Range on Protein: 980-1156
Range on HMM: 97-281/302.0
QGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPDDTE---VYGDIKVTLIET-EPLAEYVI-RTF---TVQ----KKGYHEIRELRLFHFT
  | ..|.. .| .| | | | .| ....|| .  ||  |. |. .    .|   |. ..  . |.|.   ..|   ||.    ||  .  . . ...|.
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

SWPDHGVPCYATGLLGFVRqvkFLNPPEaGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVH
.||||| |  |   |  ..   | .      ..|||||| |||| ..||   ...  .. | |. . |  .|. |   ||.|.| ... 
awpdhGapkeaytaldilk...fcesyk.knvlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqliyll
subfamily_hpo-7_pd Subfamily hpo-7 984-1161 1.5e-14 48.5 In-house 44-225 (263) alignment 
Range on Protein: 984-1161
Range on HMM: 44-225/263.0
QETVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWP---DDTEVYGDIKVTLieTEPLAEYVIRTFTVQK--KGYHEIRELRLFHFTSWPDHGVPCYA
 .|.. |...| | ..  .||...  | |..|| .|.|   |.  .. ...|.   |.   . ...|  . .  .   ...... . .. |...  |  |
vqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvct..tkvqsdvllktlellstlgeKkkthtvkhysykgWiekndpela

TGLLGFVRQVKflnppEAGPIVVHCSAGAGRTGCFIAIDTMLD-----MAENE-GVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE
   |  .. ..     .  ..|||||.| ||.  |  ....       . . . . .|  . ..||| .|   ..|  |  |    .|.
reilnilkvar.....nskslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmvLd
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 986-1160 1.2e-18 62.1 In-house 40-218 (255) alignment 
Range on Protein: 986-1160
Range on HMM: 40-218/255.0
TVKDFWRMIWQENSASIVMVTNLVEVGRVKCVRYWPD---DTEVYGDIKVTliETEPLAEYVIRTFTVQKK-G-YHEIRELRLFHFTSWPDHGVPCYATG
||. |...| | ..  .||.... | |..|| .|.|    .  .. |..||   |.. |. |.|| ..  . |   . .... .... |...  |  |  
tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvt..ttkssadvvlrtleitstlgekkkthtvkhysykGWieknaPelare

LLGFVRQVKflnppEAGPIVVHCSAGAGRTGCFIAIDTMLD-----MAENE-GVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAIL
.|  .. |.     .. ..|||||.| ||.  |. .. .       . . | . .|  . ..||| .|   ..|  |  |    .|
ilnilkvvr.....dsksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl
0048076 (Phosphotyrosine protein) phosphatases II 1027-1160 2.2e-25 84.4 In-house 13-140 (145) alignment 
Range on Protein: 1027-1160
Range on HMM: 13-140/145.0
YGDIKvTLIETEPLAEYVIRT-FTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEaGPIVVHCSAGAGRTGCFIAIDTMLDmaen
.|..  | .. | |... |.| ...    . . |.   .....|||||||  .  || |..... . . . ||..|||||| ||||...|.. ||     
lgslp.taldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll....

EGvVDIFNCVRELRAQRVNLVQTEEQYVFVHDAIL
.| |.........|.|| . |....|. |.....|
lg.vsleealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 1044-1157 3.2e-24 80.7 In-house 32-139 (144) alignment 
Range on Protein: 1044-1157
Range on HMM: 32-139/144.0
VIRTFTVQKKGYHEIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEaGPIVVHCSAGAGRTGCFIAIDTMLdmaeNEGvVDIFNCVRELRAQRV
 . ..| .   ....||   .....||||||| ... || |.. .. . ... ||..|||||| ||||...|.. |.     .| ..........|..| 
tvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeg.gpvlVHCsaGvgRtgtlvaaylmk....klg.lsleealalvrsrrp

NLVQTEEQYVFVHD
. |....|. |...
gavpnpgqlrfLle
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1057-1200 6.2e-30 98.9 In-house 87-231 (440) alignment 
Range on Protein: 1057-1200
Range on HMM: 87-231/440.0
EIRELRLFHFTSWPDHGVPCYATGLLGFVRQVKFL-NPPEAGPIVVHCSAGAGRTGCFIAIDTMLDMAENEGVVDIFNCVRELRAQRVNLVQTEEQYVFV
| | |. .|. .|||.||| .|  .| ....|.   .    ||..|||||||||||  ||.|..|  |.    .|||. .  .| .| ..||| |||.||
esrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyafv

HDAILEACLCGNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQT
|.|.||. |||.| |   .      .|   .|.|. | ...||. 
heavlegllcgdtliledditerveqiqwpnphtdksplqqefeg
0038934 (Phosphotyrosine protein) phosphatases II 1057-1116 4.4e-08 28.5 In-house 59-135 (194) alignment 
Range on Protein: 1057-1116
Range on HMM: 59-135/194.0
EIRELR----------------LFHFTSWPDHGVPCYATGLLGFVRQVK-FLNPPEAGPIVVHCSAGAGRTGCFIAI
 .  |.                 ..   .||.|..     || |.. |. |||  . | ..||| || ||||...| 
lvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaa
PTPc_DSPc_SM00012 1062-1161 4e-35 115.6 In-house 3-105 (105) alignment 
Range on Protein: 1062-1161
Range on HMM: 3-105/105.0
RLFHFTSWPDHGVPCYATGLLGFVRQVKFLNPPEA--GPIVVHCSAGAGRTGCFIAIDTMLDMAENE-GVVDIFNCVRELRAQRVNLVQTEEQYVFVHDA
. .|.|.|||||||.... .| ..|.||  .  ..  .|.|||||||.||||.|.|.|..|.. |.| . ||||..|.||| || ..|||||||.|...|
khyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyra

ILE
.||
lle
subfamily_PTPDC1_pd Subfamily PTPDC1 1064-1157 9e-09 30.0 In-house 85-170 (182) alignment 
Range on Protein: 1064-1157
Range on HMM: 85-170/182.0
FHFTSWPDHGVPCYaTGLLGFVRQVKFLNppEAGPIVVHCSAGAGRTGCFIAIDTMLdmAENegvVDIFNCVRELRAQRVNLVQTEEQYVFVHD
..  .|.|.||.   . .|  |. |.|    . | . ||| || ||||  ||   .   |..   ..  . .. .|..| . .|| ||  .|..
vynfgwkDygvasl.eriLdivkvvafal..qegkvavhChaGlGrtGvliacylvy..akr...ltaekaiklvrskrpksiqtreqvelvke
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1090-1163 6.9e-11 36.1 In-house 259-344 (349) alignment 
Range on Protein: 1090-1163
Range on HMM: 259-344/349.0
FLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLD---MAENEGV---------VDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEAC
.|.  .  ...|||||| |||| .. .| .|.   . .|| .           |.  | ||| ||...||   |......|.|. .
yldtdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyf
subfamily_eak_pd Subfamily eak 1092-1164 4.4e-07 23.6 In-house 233-306 (332) alignment 
Range on Protein: 1092-1164
Range on HMM: 233-306/332.0
NPPEAGPIvVHCSAGAGRTGCFIAIDTMLDMAENE--GVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACL
 ||   || . .. |. |.| |. || .. . .|    .  . . .   . .|.  | .. |. |.....|.  |
tppsfapi.iqsarGsaraGvfvvidllirlidnkkknlysvedlilkvkskrihsvlvalqhsfiyeivldyll
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1095-1160 2e-14 48.1 In-house 261-341 (350) alignment 
Range on Protein: 1095-1160
Range on HMM: 261-341/350.0
EAGPIVVHCSAGAGRTGCFIAIDTMLD------MAENEG--------VV-DIFNCVRELRAQRVNLVQTEEQYVFVHDAIL
.. ||.|||||| |||| ....| .|       . ..|         .   |.  | ||| ||...||. .|..|...|.|
rsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeall
subfamily_CG42327_pd Subfamily CG42327 1096-1158 4.3e-14 46.9 In-house 247-310 (319) alignment 
Range on Protein: 1096-1158
Range on HMM: 247-310/319.0
AGPIVVHCSAGAGRTGCFIAIDTMLDMAENE-GVVDIFNCVRELRAQRVNLVQTEEQYVFVHDA
 ||.||||| |.||||  || |  .   |.    ||| . |  .| .| . |.| ||| |..  
qGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1099-1164 1.7e-18 60.8 In-house 1-66 (69) alignment 
Range on Protein: 1099-1164
Range on HMM: 1-66/69.0
IVVHCSAGAGRTGCFIAIdtMLDMA--ENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACL
.|||||.|.|||| ||||  |..||    | .||||| |. .|  |  .|  | .|.|.|||. ||  
mvvhcssgtgrtgtfiai..mvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvealk
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1100-1165 6.5e-18 58.9 In-house 1-66 (69) alignment 
Range on Protein: 1100-1165
Range on HMM: 1-66/69.0
VVHCSAGAGRTGCFIAIdtMLDMA--ENEGVVDIFNCVRELRAQRVNLVQTEEQYVFVHDAILEACLC
|||||.|.|||| ||||  |..||    | .||||| |. .|  |  .|  |..|.|.|||. ||   
vvhcssGtGrtGtfiai..mvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvealkl
0050432 (Phosphotyrosine protein) phosphatases II 1162-1459 3.1e-80 265.1 In-house 11-301 (308) alignment 
Range on Protein: 1162-1459
Range on HMM: 11-301/308.0
ACLCGNTAIPVCEFRSLYYNISR-LDPQTNSSQIKDEFQTLNIVTPrvrPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLisvdGESSNYINAALMDSH-
..|...| |.|. ..  .... . |.......... ||..|. |.|   ....|..|||.|.||||..|.||.|..  .|    .|.|.|||| ..| . 
lllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkp...lleysvallpenkdkNrykdilpydhsRVkl....degsdYInAsyvdgys

-KQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQ--FCMQYWPEK---TSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPqdGYRIVQH
 |.| .|..||.||||||.||||.|...|.. .|||.. .  .   | ||||..   .| .||...|...| ....|...| ....|.  .   .|.|.|
sklprkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdg..esrtvth

LQYIGWPaYRDTPPSKRSLLKVVRRLEKWQeqydgREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVA
..|..||   ..||| ..||. .....|..     ..| .|||| .| ||.|||.|.  ..|...... .|||..||.||  . .||.|.|||.|.|...
fhytnWp.dhgvPpspeilldflelvrksl.....pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyral

LEYLSS
||||..
leylkl
0051299 (Phosphotyrosine protein) phosphatases II 1166-1457 2.5e-79 262.0 In-house 1-286 (288) alignment 
Range on Protein: 1166-1457
Range on HMM: 1-286/288.0
GNTAIPVCEFRSLYYNISrldpQTNSSQIKDEFQTLNIVTPRvrpEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAA
|.|.|.| |...|....     ... .....||..|  ..|     ..|..||| |..|||..|.||.|..  .| ..|| |.|.|||| ..| .... .
gdteisveellklvlkll....angltglleefeellsllpd...ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyidgynlkrk

FVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQF--CMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNM--ARPQDGYRIVQHLQYIGWP
|..||.||||||.||||.|...|.. .|||.. .  .   | ||||...| .||.|.|...| ....|...| ... |.   .... .|.|.|..|..||
fIatqgPlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwp

aYRDTPPSKRSLLKVVRRLEKWQEqydGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
   ..|.| ..||. .|.. |...    ..| .|||| .| ||.|||.|.  ..|...... .||...||.||. . .||.|.|||.||||..||||
.dhgvpdspellldflrlvrkala...sgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvyealleyl
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 1166-1460 1.4e-75 249.4 In-house 1-293 (298) alignment 
Range on Protein: 1166-1460
Range on HMM: 1-293/298.0
GNTAIPVCEFRSLYYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVD-GESSNYINAALMDSHKQPAA
||| | . ... .  ...  ..... .. ..|||.|| |. ... |  ...  |.|..||| .|...|| .   | ..|  | |.||||. ....|.  |
gnteieaedlkaalqklaavkkkkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrna

FVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQ--FCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPqdGYRIVQHLQYIGWPAy
|..||.||..||.||||.| ... ...|||...   .   . .|||.. .  || |.|.  | .   |.| | . . .  .   . | |..|... ||  
fiatqaPltetvedFWrmvteedigtiVmltnleeldktkyhkywPdegketygeitvsllskeefadlivrklkvskkkee..kerevrqlhftsWpd.

RDTPPSKRSLLKVVRRLEKWQEQydGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF
...|  ..|.|...|. ...|.|    .   .|.| .| ||||||.|| || | ..... .|||..||.||... ..|.| |||.|.||. ||.|.||
kgvpenatsvldllrkvrasqqq..agnkpvivqCsaGvgRsGtfiaidsvlervkkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavlealdsf
0043336 (Phosphotyrosine protein) phosphatases II 1173-1457 8.7e-70 230.7 In-house 5-277 (278) alignment 
Range on Protein: 1173-1457
Range on HMM: 5-277/278.0
CEFRSLYYNISRLDPQTnssqIKDEFQTLnivtPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGE-SSNYINAALMDSHKQPAAFVVTQHP
...  ..... . ....    .. ||..|    ... ....||.||| |.||||..|.||.|...  | ...|. .|.|||| ..| ...| .|..||.|
kdllkallelllnlktl....lllefeel....lsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgP

LPNTVADFWRLVFDYNCSSVVMLNEMDTAQF--CMQYWPeKTSGCYGPIQVEFVSADIDEDIIHRIFRICNmaRPQDGYRIVQHLQYIGWPaYRDTPPSK
||.||.||||.|........|||.| .  .   | |||| ..| .||...|.... . ..|...| ... |  .  . .|.|.|..|.|||   ..|.| 
lpetvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeehlddytvrtlevtn..lgdgesrtvthyhylgwp.dhgvpesl

RSLLKVVRRLEKWQEqydGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
 .||. .... ...|    ..| ..||| .| ||.|||.|.  ..|...    .|....||.||. . ..|.|..||.|.||..||||
sllldflkavreale...dsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyealleyl
0045450 (Phosphotyrosine protein) phosphatases II 1179-1457 5.2e-71 235.2 In-house 14-304 (307) alignment 
Range on Protein: 1179-1457
Range on HMM: 14-304/307.0
YYNISRLDPQTNSSQIKDEFQTLNIVTPRVrPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG--ESSNYINAALM--------DSHKQPAAFVVT
.. . .|..... . .. ||..|. ||... . ..||.||| |.||||..|.||.|..   | |.||  |.|.||||  .        |..... .|..|
llllvllllldfltgllkefekllsvtvfl.lgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgydlkrkfIat

QHPLPNTVADFWRLVFDYNCSSVVMLNEMD--TAQFCMQYWPEK-TSGCYGPIQVEFVSADIDEDIIHRIFRICNMaRPQDGYRIVQHLQYIGWPaYRDT
|.|||.||.||||........ .|||.| .  . . | ||||.. .. .||...|...| ........| ... .. .. .  |.|.|..|.|||   ..
qgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdl.dgtgesrtvthfhytgwp.dhgv

PPSKRSLLKVVRRLEKWQEQYdGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNI---IDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
|||  .||. .....|..|.. ...|...|||  | ||.|||.|.  ..........   .|....||.||. ....|...|||.|.||..||.|
ppsfeelldfieevrkaleel.pkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeallell
0049772 (Phosphotyrosine protein) phosphatases II 1179-1458 5.8e-39 130.0 In-house 3-281 (314) alignment 
Range on Protein: 1179-1458
Range on HMM: 3-281/314.0
YYNISRLDPQTNSSQIKDEFQTLNIVTPRVRPED-CSIGLLPRNHDKNRSMDVLPLDrCLPFLISVDGESSNYINAALMDSHkqpAAFVVTQHPLPNTVA
.|...... ....... .....|| ....| ||  . .. |..|.||||..|.|| | .. .| ......|.||||  .|..    .|..||.||..|| 
ayplasfsellihddllklllvlnrrslsvlpeltilvadlflnrdknryldilpad.nrvilpglpvsgsdyinasyvdgf...lkfIatqgpleitvv

DF----------WRLVF--DYNCSSVVM---------------------LNEMDTAQfcmqywpektsGCYGPIQVEFVSadidediihrifricnmARP
||          ||.|.  |.|.  .||                     |...|  .           . . .  .|.                    . 
dfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...........neptaadlellk.................eel

QDGYRIVQH-LQYIGWPAYRDTPPSKRSLLKVVRRLEKWqeqydGREGRTVVHCLNGGGRSGTFCAICSvceMIQQQNIiDVFHIVKTLRNNKS-----N
 |. .  .. ..|. .| . ...|. . ...... .|..      ..|...|||  | ||.|||....    .. .... ..  ... .|.  .     .
ydpelferlgikylripvpDgsaplledfdeflefieea.....dkggpvlvHCkaGkgRtgtfvvaay...lmkllgv.sleealedvrlkRpinpnpg

MVETLEQYKFVYEVALEYLS
..|.|||| |..|. ||||.
fieqleqyefilealleylk
0039614 (Phosphotyrosine protein) phosphatases II 1180-1458 2.7e-75 248.9 In-house 20-290 (297) alignment 
Range on Protein: 1180-1458
Range on HMM: 20-290/297.0
YNISRLDPQTNSSQIKDEFQTLNIVTPrvrpeDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG--ESSNYINAALMDSHKQ-PAAFVVTQHPLPNTV
  . .|.......... ||..|  ..|     |.||.||| | ||||..|.||.|..   | ..||  ..|.|||| ..| ... . .|..||.|||.||
dlllllekansktllllefeellslkp.....dysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrkfIatqgPlpetv

ADFWRLVFDYNCSSVVMLNEMDTAQF-CMQYWPEKTSgCYGPIQVEFVSADIDEDIIHRIFRICNmarpQDGYRIVQHLQYIGWPaYRDTPPSKRSLLKV
.||||.|........|||.. .  .  | |||||... .||...|.... . ......| ... |     .  |.|.|.||.|||   ..||| ..||..
edFwrmvweqgvtvivmLtklvelgrkcaqywpeegg.tygdftvtllkvehldgytvrtlevtn....ngesrtvthfqytgwp.dhgvppslelllef

VRRLEKWQEQYdGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLS
.. ........ ...|...||| .| ||.|||.|.  ..|...    .||...||.||. ....|.|..||.|.|...||.|.
lelvrealael.pkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellk
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 1181-1460 2.3e-55 182.6 In-house 9-281 (287) alignment 
Range on Protein: 1181-1460
Range on HMM: 9-281/287.0
NISRLDPQTNSSQIKDEFQTLNIVTPrvRPEDCSIGLLPRNHDKNRSMDVLPLDRclpFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFW
.... ...... . |. |..|. ||   |...  ... ..|.||||. ..|. |    . . . ||  .||||. .|..|.  ||.... |. ||. .||
efvakghakgnegfknqftvleqvtq..redevthniasqnkdknRltqilvpdn...yrvllkgehpdyinavfidgykekkafiiaesPmfntarnfW

RLVFDYNCSSVVMLNE--MDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHlQYIGWPAYRDTPPSKRSLLKVVRR
.|. | | . .||| .   .. . | |||||..| ..|. ..|... .. .. | | ... |  . .|  ...|. |.  |.  .. .  . .|| . ..
kliddrnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellneevnagyierklevknknkagdkqqvkqy.qitnWdstgkvtepqtillvieem

lekWQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF
    ..|.   ..  |||| .. |||..|||.    .  ... .|||| ..|  |  | ..| | |||||.... ||||.||
...yktqrkrgntsivvhCsdtvGrsamfcaaattinkckteGviDvfqvlksqriqkpgsvqtveqykfindivleyldsf
0036941 (Phosphotyrosine protein) phosphatases II 1184-1458 5.5e-76 251.0 In-house 5-278 (297) alignment 
Range on Protein: 1184-1458
Range on HMM: 5-278/297.0
RLDPQTNSSQIKDEFQTLnivTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLisvDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLV
.|.......... ||..|   .|.  . ..|..|||.| .|||..|.||.|..   |   |.|.|.|||| ..| .... .|..||.||||||.||||.|
llekllflalllkefeel...lpllllgslsvallpenleknRykdilpydhtRVkl...ddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmv

FDYNCSSVVMLNEMDTAQF--CMQYWPEK--TSGCYGPIQVEFVSADI--DEDIIHRIFRICNMarPQDGYRIVQHLQYIGWPAYrDTPPSKRSLLKVVR
...|....|||.| .  ..  | ||||..   | .||...|...| ..  ..|.. | ... ..    .  |.|.|..|.||| . ..|.| .|||. ..
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdt..gngesrtvthfhytgwpdh.gvpespaslldfie

RLEKWQEQYdGREGRTVVHCLNGGGRSGTFCAICSVCEMIQ---QQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLS
...|.....  ..|...||| .| ||||||.|.  ......    .. .|.. .||.||. . ..|.|||||.|.||. ||.| 
lvrkvlkll.psggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellk
0047943 (Phosphotyrosine protein) phosphatases II 1184-1457 9e-74 243.7 In-house 4-272 (273) alignment 
Range on Protein: 1184-1457
Range on HMM: 4-272/273.0
RLDPQTNSSQIKDEFQTLNIVTPrvrPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLisvDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLV
.|.......... ||..|  ..|   . ..|..|||.|.||||..|.||.|..  .|   ....|.|||| ..| .... .|..||.||||||.||||.|
llekllgltllleefelllslkp...lltysvallpenkdknrykdilpydhsrvkl...gdggsdyinAsyvdgynlkrkfiatqgPlpntvedfwrmv

FDYNCSSVVMLNEMDTAQF--CMQYWPEKT---SGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQdgYRIVQHLQYIGWPaYRDTPPSKRSLLKVVRR
...|.. .|||.| .  .   | ||||..    |  ||...|...| ....|...| ... |.  ..  .|.|.|..| |||   ..|||  |||. .. 
weqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtge..srtvthfhytgwp.dhgvppslesllefiel

LEKWQEQYDGReGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
..|..|.. .  | .|||| .| ||.|||.|.  ......  . .||. .|| ||. . .||.|.|||.|.||..||||
vrkalealpsn.gpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflyealleyl
subfamily_PTPN13_pd Subfamily PTPN13 1185-1458 1.4e-42 140.9 In-house 4-270 (273) alignment 
Range on Protein: 1185-1458
Range on HMM: 4-270/273.0
LDPQTNSSQIKDEFQTLNIVTPRvrpEDCSIGLLPRNHDKNRSMDVLPLDRCLpflISVDGESSnYINAALMDS--HKQPAAFVVTQHPLPNTVADFWRL
|  . .. | ..||..|. . |    ..|..|   .|.||||  .||| |.     . ...|.. ||||.|.     |.   ....| |||.||.|||..
lqkkldqqqPaeefkelrelkpl...dtcevgkkkenkdknryrnvlPydetr...vklgdegg.yinaslikvpvgkdeyeyiacqGPlPetvkdfwqm

VFDYNCSSVVMLN-EMDTAQ-FCMQYWPEKTS---GCYGPIQVEFVSADIDEDIIHRIFRICNMARpqDGYRIVQHLQYIGWPAYrDTPPSKRSLLKVVR
|.. ... ..|.  | .. .  | .||||...     .. ..|| .     ..   | . . ...      | |.||... || . ..| |  .||..|.
vweqkaeviamvtlekekgkvkchrywPesknkklkvsnrlevellkvqkldgfvvralavkdses..gesrevahlnfvkwPdh.gvPssaaellqfva

RLEKWQEqydgREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLS
.. . |.     .|  ||||  | |||||. .|  | ..|.... .|| .||..||. .  .| | .|| |||...|| |.
evrrlqt....dagPivvhcsaGiGrsGtlitidvvlglierdkefdvkeivrklreqrqgvvqtkdqyifvykailevlk
subfamily_PTPN14_pd Subfamily PTPN14 1185-1458 1.6e-41 137.2 In-house 16-297 (300) alignment 
Range on Protein: 1185-1458
Range on HMM: 16-297/300.0
LDPQTNSSQIKDEFQTlniVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSH--KQPAAFVVTQHPLPNTVADFWRL
|. . .....  |..    ....    ..| . || | .|||  |||| . .   |..   .|..||||. .      .   ..|.| ||..|| |||..
lekkleegkvfteyer...ipkkredallstaklpenaeknrfkdvlPyednrvelsptkenstgyinassikvsvggkersyivaqgPleltvqdfWqm

VFDYNCSSVVMLNEM--DTAQFCMQYWPEK----TSGCYGPIQVEFVSADIDEDIIHRIFRICNMarPQDGYRIVQHLQYIGWPAyRDTPPSKRSLLKVV
|.. . . .||| |   |  . ...|.|..     .  .|  .|     .  . .| . ...  .  |   .| | ||||. ||  .. |.  .. |. .
vWeqgvqlivmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhl..pskeertvwhlqytDWpd.hgvPeDvkgflsyL

RRLEKWQEQYDG------REGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLS
....  ... .       ..   .|||..|.||.|       . . ..... ||. .....||. .  .|.|| ||||||.| ..|| 
eevqsvrrktnseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehneeidikkvlarLreqrmllvqtlaqYkfvYkvlikylk
subfamily_PTPN6_pd Subfamily PTPN6 1186-1457 6.4e-47 155.0 In-house 20-297 (306) alignment 
Range on Protein: 1186-1457
Range on HMM: 20-297/306.0
DPQTNSSQIKDEFQTLNIVTPRVRpEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMD--SHKQPAAFVVTQHPLPNTVADFWRLV
. ... . ...||..|.    . .  . . |  |.|. |||   .|| |     | . .   |.||||  ..  .... .... ||  |..||.||||.|
eeslekagfeeefeelqqeeakkl.lsrkegakpenkeknryknilPfDhtrvilkepsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmv

FDYNCSSVVML-NEMDT-AQFCMQYWPEK-TSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDgYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLE
.. |.  .||. .|..   . |..|||.. ..  || |.|. || .  .| | | ...... . ..  | | ....  ||   ..| ..  .|. .. ..
wqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvseksladYilRelsvskkkkkke.erevfqyhfksWPd.hgvpkdpgavLdfledvn

KWQEQYD-GREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNI---IDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
. ||.    ..| .|||| .| || |||  |  . ..|... .   ||. ..||..|. .| .| | .||||||..  .|.
rkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikkyi
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 1188-1455 8.1e-54 178.1 In-house 30-289 (319) alignment 
Range on Protein: 1188-1455
Range on HMM: 30-289/319.0
QTNSSQIKDEFQTLNIVTprVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDY
. . .... ||. .  ..  |   | .   |..| |||| ...|. |.    |  ..| | |.||||. .. ....  .. .| ||.||.|||||....|
dddltklevefrracklg..vnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkdkyiaaqGPldntladfWrmiwey

NCSSVVMLNemdtAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIvQHLQYIGWPAYrDTPPSKRSLLKVVRRLEKWQEQY
|||..|.|      . | |||| |.   ..  .|.  | .  .. . | ... . .. .|  .| .   . ||| .   | .   |...|..... ... 
ncstivllt....kdkcsqywplkivikeerfkvkvdsveetaeyvvrdielsedgkekdirki.tqfhflGwpdv.Gvpdypsdlmrlvkkvrhltske

DGREgRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALE
..|.   ||||  | ||.|.. ..  . ....... .||...|. ||......|. | ||||.|   ||
nhra.nivvhcsaGvGrtGvyivldvlldrmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 1188-1460 1.6e-49 163.4 In-house 16-286 (290) alignment 
Range on Protein: 1188-1460
Range on HMM: 16-286/290.0
QTNSSQIKDEFQTLNIvtpRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGE---SSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVF
... .. ...|..|.      ...   .|| . |. .||. .... |     |  . |.   . .||||. .. .|.  ....|| |..||..|||.|. 
akgnegfrnqfkmlds...gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykekkqyiatqgpvsntlvdFWkliw

DYNCSSVVMLNEM--DTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPqDGYRIVQHLQYIGWPAYRDTPPSKrSLLKVVRRLEKw
. ... .||| ..  .  . | ||||.. .  ||..... ..  . ...|.| ... |.    .  ..|...|   |.   . .  . . | |... .| 
qekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetlneyierklevknknsa.gakqsvtqyqitnwdstgkvtnpq.tillvieemyk.

qEQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF
  |.   ..  |||| .. |||..|||.    .  ...  ||||...|..|  | ..|.| .||...... |.||.||
.tqrkrgntsivvHCSdtvgrsavfcaaattinkcktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltyldsf
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 1189-1460 8.2e-61 200.8 In-house 20-286 (319) alignment 
Range on Protein: 1189-1460
Range on HMM: 20-286/319.0
TNSSQIKDEFQTLNIVTPRvrpeDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYN
| . ... ||..|.. ..     . .    ..|..|||  ..|. ||.   | ..|| |.|.||||. .|....  .|. || || ||. ||||.|....
tgetllekefkllkeavnd....tfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqerekfiatqaPlentiedfWrmvWeee

CSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRIcNMARPQDGYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKWQEQ
.| ||||...      .. .||||..   || . |.  . .  ||.| | . . | .  .   | |.| ||  ||   | | . .|||....|..| .|.
ssivvmltklveklkvklkkywpeenfeeyGrlivtleeeeeledyiirklkl.nkkssevetRevkhfqyteWpd.hdvPekatslldllkrirksrek

YDgrEGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF
 .  .|  |||| .| || |||...  . | .......|||..|..||  .  ||.. |||||.||. ||.....
tq..sgPivvhCsaGvGRtGtfivldamlervkeegvlDvfstvsrlRtqRnimvqrpeqYkfiyealleaveag
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 1189-1454 6.6e-58 191.0 In-house 18-276 (288) alignment 
Range on Protein: 1189-1454
Range on HMM: 18-276/288.0
TNSSQIKDEFQTLnivTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLIS-VDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYN
.| .....|...|   ..  . .. ..| |..|..|||  ..||.|     |    ......||||. .|..|.  ... || ||..|| |||.||....
rnrtgfseeynsL...aalektksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyidgekkkkkyiatqgPladtvndfWelvyenk

CSSVVMLNEM--DTAQFCMQYWPEKTS-GCYGPIQVEFVSADIDEDIIHRIFRICnmarPQDGYRIVQHLQYIGWPAYRdTPPSKRSLLKVVRRLEKWQe
 | .|||.|.  .  . | .|||..     || ..|. |.    ||...| . .      . . . ....|| .||     | ||. ||...| ..  . 
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlveskeledfvlrkllle....kkkteleitqyqylaWpdhg.vPeskapllellrqvkvan.

QYDgrEGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVAL
| |   |. .||| .| ||.||| |.  . ....... |||. .|. ||... ..|.||.|| |.||| |
qad..tgpiivhCsaGvGrtgtFialdalidaveeedyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_Ptp69D_pd Subfamily Ptp69D 1189-1457 2.6e-54 179.4 In-house 20-286 (307) alignment 
Range on Protein: 1189-1457
Range on HMM: 20-286/307.0
TNSSQIKdEFQTLNIVtprVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYN
|.   .| |...|.       . .....    |  |||. |. . |.    |  . | |.|.||||  . ..|.   |.. | |. .|. ||||.. . .
tdfglak.eyekLear...eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekkkfiaaqdPveatigDfWRmiaeqe

CSSVVMLNEMDTAQF--CMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMAR----PQDGYRIVQHlQYIGWPaYRDTPPSKRSLLKVVRRLEK
   .||| ...  .   | .|||. .   || | |..|| .  .| |.| . . ..       .|  ..||. .| ||.     | . |.|||.......
vtlivmlsnlteknrkkcakYWpiedevqygdilvklvseekhsdyiiReldvskkkeesgevedsrkvvqy.hytgWk.DskvPevargllklieqvre

WQEQYdgrEGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
 ...    ..  |||| .| ||||.| |..|. . ... . .|.|..|| ||.... .|. ||||.|.|   |.| 
lykln...rsPivvhCsaGvgrsgifvaldsllqqlkaedkvdifetvkdLrsqRnllvqsleqYvflyralldys
subfamily_PTPRB_pd Subfamily PTPRB 1189-1457 4.9e-54 178.3 In-house 22-285 (293) alignment 
Range on Protein: 1189-1457
Range on HMM: 22-285/293.0
TNSSQIKDEFQTLNIVTprvRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGE-SSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYN
 .  ....|...|. |    . . ...  |..|..|||  ..|| |     | ....| .|.||||  .. ...|  |..|| |||.|| ||||.|.. .
dsdlrfseeyeelkavg...kdqavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynsprefiatqGPlpetvddfWrmvwekk

CSSVVMLNEMD--TAQFCMQYWPEK-TSGCYGPIQVEFVSADIDEDIIHRIFRICNmarpQDGYRIVQHLQYIGWPAYrDTPPSKRSLLKVVRRLEKWQE
.| .||| ..     . | .|||.. ..  || |.|..|. .  || . | ..|..    ..  | |...... || . . | . ..||. ||......|
ssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeeeledwvirelkiek....ekeerkvrqyhftsWpdh.gvPektktlldfvrtvreaie

QyDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
. . ... .||||  | ||.||| |.  . . |......|.| ||  ||... ..| | .|| |.... |..|
k.taskrPivvhCsaGvGRtGtfialdrllqaieeedyvdifgivaelReeRnllvqtekqYifihqcvldll
subfamily_PTPN12_pd Subfamily PTPN12 1189-1457 2.8e-51 169.1 In-house 5-277 (290) alignment 
Range on Protein: 1189-1457
Range on HMM: 5-277/290.0
TNSSQIKDEFQTLNIVTPRVRPED---CSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVF
... . . |||.|  .. . . |.    . |  ..|  |||  |.|| |     |   ..|  |.|||| ..   ... ... .| |||.|. ||||...
egeeefakefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgvegkleyiaaqgPLpktlddfWrmiw

DYNCSSVVML-NEMDTAQF-CMQYWPEK-TSGC-YGPIQVEFVSAD-IDEDIIHRIFRICNmarpQDGYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRL
..| . |||. .|.. ... | .||||.  . . .|...|.  . . .|.|.. | ... .    |.  |.|. ..|  ||  ...| |. |||.... .
eknveivvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkvea....qkesrkvyqfhYtaWPD.hgvPssaksllelielv

EKWQEqydGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNI---IDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
.. ||     .   ||||  | || || .||  | |......|   .|||..| .||.... .| | |||..||.  .|..
relqe...sedaPlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelv
subfamily_PTPN23_pd Subfamily PTPN23 1190-1456 5.3e-46 151.7 In-house 13-279 (288) alignment 
Range on Protein: 1190-1456
Range on HMM: 13-279/288.0
NSSQIKDEFQTLNIVTPRVrPEDCSIGLLPRNHDKNRSMDVLPLDRCLpflISVDGESSNYINAALMDSH-KQPAAFVVTQHPLPNTVADFWRLVFDYNC
. .... .|. |.    .   .. || .  .. .|||| |.|| |.     . ..|.  .||||. . .   .   |..|| ||..|..|||..|..   
gktaldkkfkeleqkqdke.arkrsiaiaklyseknrsrdilPyDhnR...vklrgskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvyeqks

SSVVMLNEM-DTAQF-CMQYWPEKT--SGCYGPIQVEFVSADIDEDIIHRIFRIcnMARPQDGYRIVQHLQYIGWPAYrDTPPSKRSLLKVVRRLEK-WQ
| .||| .  .. .  . .||||..  .  .|...|   |    |  ..|....    ...|  . |.|||.  || .   | |  .||...   |. ..
sviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvretethvervlkl..etldadavksvshlqltsWpel.GvPasPetllqfldevesaye

EQYDGREGRTVVHCLNGGGRSGTFCAICSVCEMI-QQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY
..    .   ||||. | ||.|.|. . .. . . ... ..|. ..|..||... .||.. ||.||.||. ||.
avqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavlea
subfamily_PTPRN_pd Subfamily PTPRN 1190-1453 2.1e-43 143.1 In-house 27-288 (297) alignment 
Range on Protein: 1190-1453
Range on HMM: 27-288/297.0
NSSQIKDEFQTLNivTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLI-SVDGESSNYINAA-LMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYN
| .... |...|   . .  |. ....  ..| .|||| .||| |     |  . . |.|.||||. ..|.  . .|.. || ||..||||||..|..  
nkdrlekewealc..ayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprapayiatqgplastvadfwqmvweqG

CSSVVMLNEMDT--AQFCMQYWPEKTSGCYGPIQVEFVSADI-DEDIIHRIFRICNMARPQdgYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKwqe
.  .|.| ...    . | .|||.. |  |.  .|..||  |  .| . | | . |.   .   | |  . .. ||. ...|.| .|||.  |...|   
vvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtse..trtvtqfhflswpe.egvPasaksllefrrkvnk...

QYDGREGRTVVHCLNGGGRSGTFCAICSVCE-MIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVA
 | ||    |||| .| ||.|....|  |.. ...  . ||.   .. ||......|.| .|..|.. . 
syrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltav
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 1190-1458 6.5e-39 128.4 In-house 13-294 (301) alignment 
Range on Protein: 1190-1458
Range on HMM: 13-294/301.0
NSSQIKDEFQTLNivtpRVRPEDCSIGLLPRNHDKNRSMDVLPLDR--C-LPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDY
.| ........|.    ..... |..||  .|.  ||  .. ..|     |    ..|  . .||||  .|. ..  .|...| |. .|..|||||....
hsnkfeeqykelk....egedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgysekkkfiaaqgpmkktlvdfWrliwqe

NCSSVVMLNEMD--TAQFCMQYWPE--KTSGCYGPIQVEFVSADIDEDIIHR--------------IFRICNMARPQDGYRIVQhLQYIGWPAYrDTPPS
  .|.||. ...  | . | ||||.  ..|  .||..|..|.  .  | . |              | |  .. . .... ..| || . ||      . 
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlq.lqvtdWpqd.Gvvre

KRSLLKVVRRLEKWQEQYDGreGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLS
.|  |.|.    . | . .|  |  |||| .. .|||..|..    |  . . ..||| ..|..| .|  .| ||||| ..|.|  .||.
prtvLqviddvihrqqkigg..gpvvVHCSdtVsrsGvYcsvsiglEQckaegVVdvfqvtkavrrskpgaVtTLeqytsiydvidmylq
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 1190-1457 2.3e-36 120.2 In-house 18-279 (439) alignment 
Range on Protein: 1190-1457
Range on HMM: 18-279/439.0
NSSQIKDEFQTLNIVTPRVRpedCSIGLLPRN--HDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDY
.   .|..|...| . |  .   |   |. ..  . |||  || ..|     |  . |   | ||||  .. . ..  .. || |  .|. ||||||.. 
kqeifkeifekinstspdya...ciaslaaqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddklyiatqgpkkettddfwrlviek

NCSSVVMLNE-MDTAQfcmqYWPEKTSGCYGPIQVEfVSADID-EDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKWQE
... .||| . ... .    ||| ..  ||| | |  |  .|.  . . | |.. |     .  | | ...|| ||  .. |     .|. .| ..  ..
ktvtivmltnlvesyk....ywpsdaevcygdiavr.vdrnielpnyvirgfkvfnerdttekertvlqfhyiawpd.knvpaqashvldflrainsand

QYDgrEGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
. .   |  ||||  | ||.||  |.    | .. .| .|.  ||| ||... .||..| || |.|.  || .
kee..ygpvvvhcsagvGrtGtiialdialeqlklenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 1190-1457 1e-19 65.1 In-house 24-285 (302) alignment 
Range on Protein: 1190-1457
Range on HMM: 24-285/302.0
NSSQIKDEFQtlNIVTPRVRPEDCSIglLPRNHDKNRSMDVLPLDRClpfLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTV---ADFWRLVFDY
.....|.||.  .| | .|  | |..    .| .||.| ||  ||     |. ...|  .|.||. ..  .     ...| |  ...   ..|||.||. 
dtaevkkefk..kidtmkvdlekCka..fkknlkknqsedvpildsn...lvkleaepdsyvnaskvevPeltrsiilaQlpkvdsedsveeFWrmvfqe

NCSSVVMLNEMDTAQF-CMQYWPeKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYR-IVQHLQYI-GWPAyRDTPPSKRSLLKVVRRLekWQ
.. |||.|   .. .    ...| |.|| |   .  ||     |      .| .    |..    ..  .. .  |..    | .  .| | .  .  ..
kivsvvilvgeeelkktlselfp.kksgdykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkq.kkvpvkyaeliktaakv..fa

EQYDGREgRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
.. .. | .||.   || || |.| .   . | .|...   .  |||..|......|..|.|| ..| ..| |.
kkikade.ntvivSknGaGRagafltlavaveklqkgkepnikeivksiRsqRpravdslkQyvslyialllyi
subfamily_CG7180_pd Subfamily CG7180 1192-1457 5.5e-68 223.8 In-house 13-290 (296) alignment 
Range on Protein: 1192-1457
Range on HMM: 13-290/296.0
SQIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSS
 . . |.. .  .|||.. .||  ||   | .|||  .|.| |   ..| ..|||. |.||||. .||. ......||. |  .|| .|||||.| ..|.
rkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyvdsflkkkeyivteapkketvdefWrlvydeeisa

VVMLN-EMDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNM--------ARPQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEK
||.|  ..| |. . .|||.|.   ||.| || |. .   ..  | |..  .        .  .   |||...|.  |.     | |  .|....|| ..
vvvLtktfdfakmypsywpnkskeqygeifveiveekqyanlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrl

WQEQY--DGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
|.|.   |  || .||.. .|..||| ..||    |...... .|||. |||||... ..||. |.||..|.| ||..
wrekvdedpeegPvvvvssdGasRsGvylaidanlelvekeeevdvFeavktlrrsRpqLvenveeYkyiYdvlleav
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 1192-1456 2.1e-31 103.9 In-house 6-258 (267) alignment 
Range on Protein: 1192-1456
Range on HMM: 6-258/267.0
SQIKDEFQTLNIVTPRVRPEDCSIGllPRNHDKNRSMDVLPLDRCLpflISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSV
 .|. ||. .. ...      .||.    |...||  |.|| |      . .  .  .||||. ....|.  ||.||| || ||..||. .. |.... .
ceiekefelikkisdtsstisqsia..eknqernrlddnlpyddtr...vilrtkeeeyinasyvegyktknafivtqdplkntitdfltvihdqkvpvi

VMLNEMDTAQFcMQYWPEK--TSGCYGPIQVEFVSADIDEDiiHRIFRICNMARpQDGYRIVQHLQYIGWPAYRDTPPSKRSLLKVvrrLEKwqEQYDGR
|.|    | .   ..|| |   .  |  . ||.     ..|  ..|  .    . ..  . |    |  |    .  |  . |. .   | |  .| .  
vlltkvftdni.rlfwPPkmgqakkyqdltvehslekeend..yqiitlelkfk.nesahnvtlyyykkwnintnnkpylkplfgi...lak..nqleng

EGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY
.   ||.| .| ||||||  | |  | ...... |.|. .. .|. .  .|.|.|.| ...|.  ||
nrPlvvacsdGvGrsGtflvidsqleraktegvsdifdflrkirsqriglvdtkeryiyihellaey
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 1192-1457 2.9e-30 100.3 In-house 16-277 (307) alignment 
Range on Protein: 1192-1457
Range on HMM: 16-277/307.0
SQIKDEFQTLNIVTprvrPEDCSIGLLPRNHDKNRSMDVLPLDRCLpFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSV
....|||. |   |    ||  ..  .  | ||||  ||   |..   .. .|| .|.|| |  .    .|  |...| || ||. .|| .. . .  ||
qalvdefrvlakkt....pegvtveafsantdknryqdvkcqdkgr.ivvkfdglasdyihanylgiaikpkkficaqgplentqysfwamaiqekvesv

VMLNE-MDTAQF-CMQYWPEKT--SGCYGP----IQVEFVSAD---IDEDIIHrifrICNM-ARPQDGYRIVQHLQYIGWPAyRDTPPSKRSLLKVVrrl
.|| . ...|.  | |||| .      .|     | |. . |.    |||.|     . ..     .. | .||||.  ||  | .|. . . . ..   
imlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlin....vttlkvdwaqksrtiqhlqwenwpd.rgvpqinltainll...

EKWqeQYDgrEGRTVVHCLNGGGRSGTFCAICSVC-EMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
|    .||  .   ||||  | |||||  ||. |   ||. .|  |. ..|. ||...   ..|  || ... | |||.
eav..ryd..tnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqylylhrvlleyf
subfamily_ptpA1_pd Subfamily ptpA1 1192-1411 2.7e-27 90.5 In-house 21-250 (418) alignment 
Range on Protein: 1192-1411
Range on HMM: 21-250/418.0
SQIKDEFQTLNivtPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISV-DGESSNYINAALMDSHkQPAAFVVTQHPLPNTVADFWRLVFDYNCSS
 .||.||. |.     | | . | |   .|  |||  ..||...    |  . | | |.||||  .|    |  |..|| |||||.|||||.|..  |  
hkikeefrlle...esvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidga.ypkqfictqgplpntiadfwrmvwenrcri

VVMLNE-MDT-AQFCMQYWPEKTSG-----------CYGPIQVEFVS--ADIDEDIIHRIFRICNMARPQDgyriVQHLQYIGWPAYRdTPPSKRSLLKV
.|||.   .     | .||||.  |            .|   ||.|    | . .|| |  |.      .|    . . || ||| .   |   . . ..
ivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpereiitrnirltfegetrd....itqyqyegwpdhn.ipdhtqpfrql

VRRLEKWQEQ---YDGREGRTVVHCLNGGGRSGTFCAIC
.. . . |.|      |.   .|||  | ||.||||.  
lhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctav
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 1193-1457 2.4e-57 189.5 In-house 20-288 (325) alignment 
Range on Protein: 1193-1457
Range on HMM: 20-288/325.0
QIKDEFQTLNIVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISV-DGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSV
| .| |     ..| . .    .  .| | .|||  .|..||.  . | .  |  ||.||||. . ..|.   |. .| ||..|. |.||||.|..|| |
qdqdgfahefgllpsddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrddkkkdvflaaqaPltatindlWrlvldWrcsvv

VMLNEMDTA-QFCMQYWPEK--TSGCYGPIQVEFVSADIDEDIIHRIFRIcnmARPQDG-YRIVQHLQYIGWP--AYRDTPPSKRSLLKVVRRLEKWQEQ
|.|||.|.  . | .|||..   |  .|...|......   | .||.. .    ....|  | |. .|. .|.    .  | .  |.|..|  ...    
vvlneldlgkdrcavywpkemgksktfGglevklrtieeisdyvhrvldv...kqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservta

YDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
     .  .||| .| ||.|.| .. |. . . ..  .|.|  || ||... .|||| .|| ..||   |..
ntkastpilvhcsaGvGrtGvfislysalakvieesrvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_PTPRG_pd Subfamily PTPRG 1193-1459 1.4e-53 177.0 In-house 20-289 (563) alignment 
Range on Protein: 1193-1459
Range on HMM: 20-289/563.0
QIKDEFQTLNIVTpRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGESSN--YINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSS
 .. ||. |.  |   .  |..    | |. ||| ..... ||    | .. |. ..  ||||  .| ...  ||..||.||..|. ||||.... | . 
gfseefealqset.iskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyqkskafiatqgplkdtfddFWrmiWeqnvai

VVMLNE--MDTAQFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNM--A-RPQ-DGYRIVQHLQYIGWPAYrDTPPSKRSLLKVVRRLEKWQE
.||. .   .... | .|||. .|  || .||  .. ..      | . | |.      | |  . |.. .|  ||   ..| ..   |. |.. .. ..
ivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdh.gvPehslpvLifvkkssaank

QydgREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS
.     | .|||| .|.||.||.... .. . |||.|...||...|..| .. ..|.| ||| |.... || ..|
a...eaGPivvHcsaGvgrtGtyivldtllkqiqqenavnvfgflkhiraqRnflvqteEqYiflhdalleaias
0046845 (Phosphotyrosine protein) phosphatases II 1194-1458 5.9e-74 244.3 In-house 2-275 (284) alignment 
Range on Protein: 1194-1458
Range on HMM: 2-275/284.0
IKDEFQTLNIVTPRVRpEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG--ESSNYINAALMDSH-----KQPAAFVVTQHPLPNTVADFWRLVFDY
...||..|. .|. .   ..|..||| |..|||..|.||.|..  .| |.||  |.|.|||| ..| .     ... .|..||.||||||.||||.|...
leeefeellsltvkll.lslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweq

NCSSVVMLNEMDTAQ--FCMQYWPEKT-SGCYGPIQVEFVSADIDEDIIHRIFRICNMaRPQDGYRIVQHLQYIGWPaYRDTPPSKRSLLKVVRRLEKWQ
|.. .|||.| .  .   | ||||..  .  ||...|...| ....|...| ... |.  . . .|.|.|..|..||  ...||| ..||. .| .....
nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnl.gytgesrtvthfhytswp.dhgvppspedlleflrlvrell

EQyDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQN---IIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLS
|.  ...| .|||| .| ||.|||.|.  ..|......    .||...|| ||. . .||.|||||.||||..||||.
en.lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylk
DSPc_SM00195 1194-1457 1.7e-67 222.9 In-house 2-262 (263) alignment 
Range on Protein: 1194-1457
Range on HMM: 2-262/263.0
IKDEFQTLNIVTPRVrpeDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVV
.| ||..|.  |.     ... .  ..|..|||. ..|| |.    | . .. |.|.||||  .. .... ....||.|||.||.||||.|.. ... .|
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNEMDT--AQFCMQYWPEK--TSGCYGPIQVEFVSADIDE-DIIHRIFRICNMARpqDGYRIVQHLQYIGWPAYrDTPPSKRSLLKVVRRLEKWQEQYd
||.| ..   . | .||||.  ..  .| |.|..|. .... .|| | ... . ..  .  | |...|| .||   ..| |..|.|...| ..|....  
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts.

grEGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
  .| .|||| .| ||.|||..| .... ..... .|.|.||| ||... .||.|||||.|.||..|||.
..sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 1194-1457 1.7e-67 222.9 In-house 2-262 (263) alignment 
Range on Protein: 1194-1457
Range on HMM: 2-262/263.0
IKDEFQTLNIVTPRVrpeDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVV
.| ||..|.  |.     ... .  ..|..|||. ..|| |.    | . .. |.|.||||  .. .... ....||.|||.||.||||.|.. ... .|
lkeefekleestspk...etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikgankkkkyIatQgPlpstvedFWrmvweekvkiiv

MLNEMDT--AQFCMQYWPEK--TSGCYGPIQVEFVSADIDE-DIIHRIFRICNMARpqDGYRIVQHLQYIGWPAYrDTPPSKRSLLKVVRRLEKWQEQYd
||.| ..   . | .||||.  ..  .| |.|..|. .... .|| | ... . ..  .  | |...|| .||   ..| |..|.|...| ..|....  
mlteeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegk..eetrkvtqyqyknWpdh.gvpdstksvlellravkksksts.

grEGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
  .| .|||| .| ||.|||..| .... ..... .|.|.||| ||... .||.|||||.|.||..|||.
..sgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN3_pd Subfamily PTPN3 1194-1454 6.1e-44 145.0 In-house 17-272 (280) alignment 
Range on Protein: 1194-1454
Range on HMM: 17-272/280.0
IKDEFQTLNIVTPRVrpeDCSIGLLPRNHDKNRSMDVLPLDRCLpflISVDGESSNYINAALMD----SHKQPAAFVVTQHPLPNTVADFWRLVFDYNCS
.  .|..|    | .   ..|.  .|.| .|||  |.|| |      .... ....||||  ..    |...   ...|| ||..|..|||..|.. ..|
vlaqfeqlyrkkpgl...aisaarkpenlsknryrdilpydatr...vklkesetdyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqkss

SVVMLNEM-D-TAQFCMQYWPEKTSGC-YGPIQVEFVSADIDEDIIHRIFRICNMARpqDGYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKWQeqy
 .||| .. .   . | |||||..  . || ..|.  . | .. .. | . ... .   .  | . .|||. ||   . | .. ..|..|.|..| .   
livmlttlverGrvkChqyWPetedeleygefsvkcekedetksyvlrelvlkdket..keerkilqlqylaWpd.hgvPddsadflefvervrklr...

DGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVAL
 |.|  .||||  | ||.| . ..     .|.... . . .||.|.|. ....|.| .||||| |  |
sgkeePvvvhCsaGigrtGvlilletalalieaaepvypldivrtmrdqramlvqtasqykfvCeail
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 1195-1456 6.6e-24 79.0 In-house 14-268 (281) alignment 
Range on Protein: 1195-1456
Range on HMM: 14-268/281.0
KDEFQTLnivtPRVRP-EDCSIGLLPRNHDKNRSMDVLPLDRCLPFLI--SVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSV
|.||  |    |   | . |..   | |  ||| ...  ||     |     . .|..|| |  . |      ...|| |  .| |||||.... | ...
kqefsnl....pgdppsdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspflkrgyiltqgpkketradfwrmiwqenttai

VMLNEMDT--AQFCMQYWPEKTSGCygpIQVEFVSADIDEDIIHRIFRICNMARPQDG-YRIVQHLQYIGWPAYRdTPPSKRSLLKVVRRLEkwqeqydG
||| ..     . | .|.| ..  |   .|.. .| . ..  . . .    .    .|  |.. |  .  || ..  | |   .||..|..         
vmlcqfletnrekcaeyfprnahcc...lqfdklsvsyedstvnkslvttrlnlsyegetrlithwlwkewpdwq.vpessevmlkilrkir.......a

REGRTVVHCLNGGGRSGTFCAICSVCEMIQQQ-NIIDVFHIVKTLRN-NKSNMVETLEQYKFVYEVALEY
|    |.||  | |||||. |.    . |. .  . |. .||  ||   ..  |.||.|| ....| |..
rstppvihcsagvgrsgtlmaveialqsihshftlpdikqivshlrvtgraasvqtlqqymliwkvlldf
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 1201-1310 1.1e-10 35.6 In-house 78-181 (244) alignment 
Range on Protein: 1201-1310
Range on HMM: 78-181/244.0
LNIVTPrvRPEDCSIGLLPRNHDKNRSMDVLPLDRCLpFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTA
 ||. |   |      . | |  |||    ||.|      .|    .  ||||...    . | ...||||| .|  |||.....     .|.|  ..  
qniirp..dpsvmkdafnpnnswknregaglpfdfnr.vplskgsmgntyinasfvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveee

QfcmQYWPEK
.   .|||. 
d...eywpds
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 1203-1456 4e-27 89.8 In-house 15-294 (297) alignment 
Range on Protein: 1203-1456
Range on HMM: 15-294/297.0
IVTPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGEsSNYINAALM--DSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--D
..    |.|. |    .    |||  |.|  |     |  |  | ..||||  .     ...  ....| || .|| |||.||.. .   .||. ..  |
llldeargesfssakrnsslrknryrdilatddtrvkllrvite.rdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqed

TAQFCMQYWPEKTSGC--YGPIQVEFVSADIDEDIIHRIFRICNMARpqDGYRIVQHLQYIGWPAYRdTP----PSKRS-------------LLKVVR--
  . |. |||.   .    | . |||.|   ||     .  .  . |  .  | |.| |...|| .   |      .|              .| .|   
Grdkcapywpsvvqerlkagdvvveflsstsdefdrviltelqliyr..sesrvvrhvqflswpdhG.vpsdledlvrfqaqvcscciavpmmlalvemf

------RLEKWQEQYdGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY
      .||  . ..  |.  ..|||  | ||||       . ...... | ||  |.. ||.... .|.||||....|...|. 
tamvflqleslraem.prnayllvhcsaGvGrsGvvvlsdvilaklrkkripdvaailsilreqrarlvqtleqfellydavlkk
0040438 (Phosphotyrosine protein) phosphatases II 1205-1457 8.3e-73 240.7 In-house 27-276 (317) alignment 
Range on Protein: 1205-1457
Range on HMM: 27-276/317.0
TPRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTA--Q
 ... ....|...|| |.||||..|.||.|..   | ...| ..|.|||| ..| .... .|..||.||||||.||||.|........|||.| .    .
llslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpntvedFwrmvweqgvtvivmLteleelgre

FCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMarPQDGYRIVQHLQYIGWPaYRDTPPSKRSLLKVVRRLEKWQEqydGREGRTVVHCLNGG
 | ||||....  ||...|...| . ...|..| ... ..    .  |.|.|..|.|||   ..||| ..||. ........|   ...| ..||| .| 
kcaqYwplgetltygdftvtllseeelagitlrtlevedl..gdsesrtvthfhytgWp.dhgvppspdllldfleavreale...dpggpvlVHCsaGv

GRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
||.|||.|.  ..|.... . .||...||.||. ....|.|.|||.|.|...||||
gRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl
0045098 (Phosphotyrosine protein) phosphatases II 1206-1458 1.3e-65 216.9 In-house 18-273 (278) alignment 
Range on Protein: 1206-1458
Range on HMM: 18-273/278.0
PRVRPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFlisvdgessNYINAALMDSHkqPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFC
.   | ... .|.. | |||| .|.||.|..  .         .|||| ..|..  | .|..||.|||.|||||||..........|||.|   .. . |
llgipseitpalylgnldknRykdilpydhsrVk.........dYINAsyidgy..pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

MQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGY--RIVQHLQYIGWPAYrDTPPSK--RSLLKVVRRLEKWQE----------QYDGR
 |||||. |  ||...|...| .. .|...| ....|    . ..  | |.||.|..|| . ..|..   .|.|...........          .....
aqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdh.gvpslpilksflellefirealkllaslllssllllds

EGRTVVHCLNGGGRSGTFCAICSVCEMIqqQNIIDVFHIVKTLRNNKSN-MVETLEQYKFVYEVALEYLS
.|...|||  | ||.||..|.  ..|..  .. .|....||.||. . . .|..||||.|.||..||.|.
ggpvlVHCsaGvgRtGtlvaaylmlell..eggvdlleavkelrsqRpglavqnleqyrflyefllelll
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 1207-1455 6.2e-47 154.8 In-house 19-264 (283) alignment 
Range on Protein: 1207-1455
Range on HMM: 19-264/283.0
RVRPEDCSIGLLPRNHDKNRSMDVLPLDRclpFLISVDGESSNYINAALMD---SHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQ
 | . |. |    .|. |||  ...| |.   . . .. || .||||. .    |.||   ....| || .|| |||..||| . ...||| ..  |  .
svpdldadiasadenkrknrnqeivpadq...wrvelksesrdyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlri

FCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRiVQHLQYIGWPAYRDTPPSkRSLLKVVRrLEkwQEQYDGREGRTVVHCLNGG
 | ||||.. |  ||.  |        .  | . . . . .  ..    . | |.|.|  | . ..   ||.|. . .     | . ..|  |||| .|.
kCsqyWPkrGsedyGeftvtlrkettsnsfiikelllrvnssakstll.lahyqvidWleygeqaii.nslvkfnk.vi..slqteskkgPivvhCstgi

GRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALE
||...|.|. .  . .. . ..||| .|| .|...  .| ||.|||.|.|..||
Grtavfiaasasvkdaltesvvdvfavvkimreqrmmavqtldqyklvhelvle
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 1208-1459 1.1e-54 180.7 In-house 34-285 (305) alignment 
Range on Protein: 1208-1459
Range on HMM: 34-285/305.0
VrPEDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLN--EMDTAQFCM
  .| . .|    |. |||. .. .||     |   . .  |.||||. .|..|.  ...|.| ||.|||||||||....  |..|||     .  . | 
e.eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgykrkkkyivaqgPlkntvadfWrliveekvstivmltklveggkdkCr

QYWPEKTSG--CYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGyRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKWQEQydGREGRTVVHCLNGGG
|||||...    .|...||  |    .| | | ..|..    ... | | ..|   ||     | .  |||....|..| |..  ...   .||| .| |
qYWpesktekkefgefsvelksektasdyieRklkisiededkes.rtvlqyqltdWPd.hGvpqfatsllslikrvqkdqkk..dkgvpllVhCsagvg

RSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS
|.|.|.|.    | ... ...|||...|.||... .||.||.|| |....  |.. .
RtGvfiavdialerlkkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 1210-1457 8.2e-22 72.5 In-house 24-270 (285) alignment 
Range on Protein: 1210-1457
Range on HMM: 24-270/285.0
PEDCSIGLLPRNHDKNRSMDVLPLDRCLpflISVDGESSNYINAALMDS-HKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMD--TAQFCMQY
| .|.      | | ||  ||  ..      . .     .|| |. |    |. .... || |||.|..|||..... . . |.||  .     . |  |
ppnctytayeanpdlnryadvrcieetr...vvlknhdrdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcaly

WPEKTSGCYGPIQVEFVSADIDED-IIHRIFRICNMARPQD---GYRIVQHLQYIGWPAyRDTPPSKRSLLKvvrrLEKWQEQYDGREGRTVVHCLNGGG
.|||        . |   ..  |. |   |.    .   .|       ..|.|   ||  . .|   | ...    | || .. . .|   .|||  | |
ypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpd.qlapedarpmie....lykwvkkvnpkekpicvhcsagvg

RSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
|. ||  |      | ..  |... ||. .|  . . |..  |. |.| | .||.
rtatfvgidyatirimenpniemldivremramrfqavqshmqflflyvvlmeyf
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 1211-1457 5.4e-39 128.8 In-house 10-264 (270) alignment 
Range on Protein: 1211-1457
Range on HMM: 10-264/270.0
EDCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGE-SSNYINAALMD-SHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMD--TAQFCMQY
.. ..    |..  ||..|.||  .    | ... .  ..||||  .   ........ .. |||.|. .|||.... . ...||. ..     . | .|
sesdlpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerY

WPEKTSG----CYGPIQVEFVSADIDEDIIHRIFRICnmaRPQDGYRIVqHLQYIGWP-----AYRDTPPSKRSLLKVVRRLEKWQEQYDGREgRTVVHC
||...       .| |.|  .|   .|  | .  |.    .  .  |.| | .|  ||        |.  | ..|||..| . ..... |  |  ..|||
Wpaepkekvkledgkikvlalseekeegyiltrlrle...ekgeerrlv.HfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae.PllvHc

LNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
 .| ||.||. |.  ......... .|| .|.. ||... ..|.. |||.|.|.. .|| 
saGvgRtGtlialDiavrlLeetkkvdvlaiieelRkdRmalvqhpeqyeflykavveya
0040439 (Phosphotyrosine protein) phosphatases II 1212-1457 1.9e-65 216.2 In-house 2-246 (249) alignment 
Range on Protein: 1212-1457
Range on HMM: 2-246/249.0
DCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTA--QFCMQYWP
..|..||| |.||||..|.||.|.. . | ...| . |.|||| ..|  ... .|..||.|||.||.||||..........|||.. .    . | ||||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywp

EKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMarPQDGYRIVQHLQYIGWPaYRDTPPSKRSLLKVVRRLEKWQEQYdGREGRTVVHCLNGGGRSGTFC
...|  || ..|...| .. .|...| ... |.    .  | |.|.||..||   ..|||  .||. .....|..|.. ...|...||| .| ||.|||.
lggsleygdftvtllsvevkddytvrtleltnl..ydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleel.pkggpvlVHCsaGvgRtGtfi

AICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
|.  ..|...  . .|....||.||. ....|...|||.|.||..||.|
aaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeallell
0037934 (Phosphotyrosine protein) phosphatases II 1212-1457 2e-60 199.7 In-house 1-242 (243) alignment 
Range on Protein: 1212-1457
Range on HMM: 1-242/243.0
DCSIGLLPRNHDKNRSMDVLPLDRCLPFLisvDGesSNYINAALMDSHKQpaaFVVTQHPLPNTVAD----FWRLVFDYNCSSVVMLNEMD--TAQFCMQ
..||.||| |..||| .|.||.|.   .|   .|  |.|||| |..  ..   . .||.|||.||.|    |||..........|||.| .  ... | |
sfsiallpenlsknrysdilpydhsrvkl...eg..sdyinanliyvtpr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPEKTsgCYGPIQVEFVSADIDEDIIHRIFRICNmARPQDGYRIVQHLQYIGWPaYRDTPPSKRSLLKVVRRLEKWQEQ-----YDGREGRTVVHCLNG
|||...  .||...|...|    .|...| ....|   ..| .| |.|..|..||   ..|.|  .||. .. . ...|.     .. ..|...|||  |
ywpgev..tygdftvtllseehlddytvrtlllen.ldlddltrlvihyhylpwp.dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

GGRSGTFCAICSVCEMIqqqNiIDVFHIVKTLRNNKSN-MVETLEQYKFVYEVALEYL
 ||.||..|.  .....   . .|....||.||. ... .|.|..||.|.||..||.|
vgRtGtliaaylmllll...g.vdleeavkllreqRpgkavqtpsqyrflyeallell
subfamily_PTPRA_pd Subfamily PTPRA 1212-1456 2.7e-56 185.9 In-house 49-294 (330) alignment 
Range on Protein: 1212-1456
Range on HMM: 49-294/330.0
DCSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGE-SSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWP
 . .     |..||| ...|| |    .|  ..|. .|.||||. .| .|.   |. .| |. .|| ||||...... ...||| |..    . |.||||
tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekdkfiaaqGPkeetvedfwrmiweqksativmltelkerkeekcaqywP

EKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARP--QDGYRIVQHLQYIGWPAYrDTPPSKRSLLKVVRRLEKWQEQYDGregRTVVHCLNGGGRSGT
.. .  || |.||     . .|.  | | . ...    ..  |.|. . . .||     |   . .||......| ..|. |     ||||  | ||.||
deGlvtyGnirvevedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdv.GvPfepiGmlkllkkvkklnqqsag...pivvhcsaGvGrtGt

FCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY
|... .| |... ....|||..|| ||.....|| |.|||.|.|.| |||
fivldavlervkaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlley
0042113 (Phosphotyrosine protein) phosphatases II 1213-1457 5.4e-63 208.0 In-house 1-243 (245) alignment 
Range on Protein: 1213-1457
Range on HMM: 1-243/245.0
CSIGLLPRNHDKNRSMDVLPLDRCLPFLISVDGES-SNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQF--CMQYWPE
.|..||| |.||||..|.||.|...  | ...|.  |.|||| ..| ....  | .||.|||.||.||||..........|||.| .  ..  | ||||.
ysvallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywpl

KTSGCYGPIQVEFVSADIDEDIIHRIFRICNMarPQDGYRIVQHLQYIGWPaYRDTPPSKRSLLKVVRRLEKWQEQydGREGRTVVHCLNGGGRSGTFCA
..|  || ..|...| ....|...|.... |.  . | .| |.|..|..||   ..|.. ..||.......|....  ...|...|||  | ||.|||.|
gesltygdftvtllseehlddytvrtlevtnl..gddesrevihyhylpwp.dhgvpdllellldflefvrkalae..dsngpvlVHCsaGvgRtGtfia

ICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
.  ..|...    ......|| ||. ....|.|..||.|.||..||.|
aylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeallell
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 1213-1448 1.8e-12 41.9 In-house 21-212 (255) alignment 
Range on Protein: 1213-1448
Range on HMM: 21-212/255.0
CSIGLLPRNHDKNRSMDVLpldrclpflisvdgessnyinaalmdshkqpaafvvtqhplpnTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEK
|. .. |..  |......|                                           ||. |.. .   . . |||| ..     . | .|.| .
ctehvkPekdkkrknlysl...........................................tvdkfyqtivqtktevvvmlcdfaeegvekcssyfple

TSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKWQeqydgregRTVVHCLNGGGRSGTFCAI
  .     .|. ....   |.. |  .|  .   .   . |.| .| ||.. . .|   | .|....   . .          |||| .|.||| .|  .
kdeklkladvnvtttkssadvvlrtleitstlgekkkthtvkhysykGWie.knaPelareilnilkvvrdsk........svvvhCstGiGrsaafvla

CSVCE-MIQQQN-----IIDVFHIVKTLRNNKSNMVETLEQYKF
 .|   ||.. .      .|   ... ||....  ..|  |  |
elvyqkmirsldttetveldylslleelrskrkraihtPlqlaf
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1215-1311 2.7e-16 54.0 In-house 39-146 (392) alignment 
Range on Protein: 1215-1311
Range on HMM: 39-146/392.0
IGLLPRNHDKNRSMDVLPLDRCLPFL-ISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNE------MDTAQFCMQY-
..  . |  |||  ..||.|.    | .  |   |.|.||. ..| ..  |.. .| | . .. ||||.||. | ....|...       | |. . |. 
vaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdnekayiasqgpnaaslddfwrmvfqenvttiamvtklkegdkgddartvaqfh

---WPEKT
   ||.| 
ftewPdkd
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 1216-1460 1.3e-63 209.5 In-house 4-245 (250) alignment 
Range on Protein: 1216-1460
Range on HMM: 4-245/250.0
GLLPRNHDKNRSMDVLPLDRCLPFLISVD-GESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM-DTAQFCMQYWPEKTSG
.  |.|..||| .|...|| .   | ...  . |.||||. ......  ||..||.||..|. ||||.|.... ...|||... .. . . |||| ... 
akkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyderkafiatqgPlqatiedfWrmvleeksgtivmLtnLkesektyhqywPvekae

CYGPIQVEFVSADIDEDIIHRIFRICNMARpqDGYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKWQEQYDgrEGRTVVHCLNGGGRSGTFCAICSV
 || ..|.  | ..  |...| . . .  .   . |||..|... ||  .  |   .. |........ |.| .  ..  .|.| .| ||||.|.|| .|
kyGdvtvsllskeefadytkrklklskakk..aderivrqlhfvvWPd.kgvPevatavLellkkvqasqqqag..naPvivqCsaGvgrsGafiaidav

CEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF
 | .......|||...|.||... ..||.|||| ||||..|..| |.
lerlkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkaldsv
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 1216-1455 6.3e-53 175.1 In-house 20-253 (284) alignment 
Range on Protein: 1216-1455
Range on HMM: 20-253/284.0
GLLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNemdtAQFCMQYWPEKTSGC
  |..| |||| ...|. |.    |  ..| | |.||||. .  ....  .. || ||.||.|||||....||||..|.|      . | |||| |.   
anldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkdkyiatqGPldntladfWrmiweyncstivllt....kdkcsqywplkivik

YGPIQVEFVSADIDEDIIHRIFRICNMARPQDGyRIVQHLQYIGWPAYrDTPPSKRSLLKVVRRLEKWQEQYDGREgRTVVHCLNGGGRSGTFCAICSVC
..  .|.  | .  |. . | ... . .. .|  | ..   . ||| .   | .   |...|..... ... ..|.   ||||  | ||.|.. ..  . 
eerfkvkvdsveeseeyvvrdielsedgkekdi.rkirqfhflgwpdv.gvpdypsdlmrlvkkvrhltskenhra.nivvhcsagvgrtgvyivldvll

EMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALE
....... .||...|. ||......|. | ||||.|   ||
drmkeekqvdvynfvrdlrqqrntlvqdlvqykfiysalle
subfamily_PTPN1_pd Subfamily PTPN1 1216-1455 1.8e-37 123.6 In-house 27-269 (290) alignment 
Range on Protein: 1216-1455
Range on HMM: 27-269/290.0
GLLPRNHDKNRSMDVLPLDRCLpflISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKTS-
  ||.|...||  || | | .    | .. .. .||||.|.. ..    ...|| ||||||. ||..|.. .. .|||||..     . |.||||.. . 
aklpenrnlnryrdvspydhsr...ikleradndyinaslveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvmlnkvvekeqikcaqywPqgeee

---GCY-GPIQVEFVSADIDEDIIHRIFRICNMARPQdgYRIVQHLQYIGWPAYrDTPPSKRSLLKVVRRLEKwQEQYDGREGRTVVHCLNGGGRSGTFC
    .    ..|...| .. .  . |.... |.   .   | . |  |. || .   | |  ..|| . .. .         | .|.||  | |||||||
kellledtklkvkliseerksyytvrllelenlktqe..treilhfhyttwpdf.gvpespaaflkflfkvre.sGslssdvGpavihcsaGiGrsGtfc

AICSVCEMIQQQ---NIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALE
 . ..   |...   . .|. . .  ||. .  .. | .| .| |   ||
lvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaile
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 1217-1460 4.1e-59 195.2 In-house 42-283 (318) alignment 
Range on Protein: 1217-1460
Range on HMM: 42-283/318.0
LLPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM-DTA-QFCMQYWPEKTSG
| | |. ||| ...|. |..   |  ..| |.|.||||  .| ...  |.. .| |||.|. ||||.|.. |.. .||| .. . . . . .|||.| | 
lepvnkaknryanilaydhtrvkLqmlegeegsDyinanyidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivmltqeeergkakvhryWPskgsr

CYGPIQVEFVSADIDEDIIHRIFRICNmaRPQDGYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKWQEQYDgrEGRTVVHCLNGGGRSGTFCAICSV
 || ..||  .    .| . | |.. .  . ..  |.|.  .|  ||  ...| |  |||..||. .|.|.. .  .| .||||  | || |.|.|. ..
sygklvvelkeevelsdyvlrefkvtr..teeeesrqvrqyhytsWpd.egvpesgaslldlvrqvskaqqksg..agpivvhCsaGvGrtGvfiavdil

CEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSSF
 | |......|||..||.||...  || | .||.|.|.| ||.| |.
lerikaealvDvfqtvkqlreqrnlmvqtedqyefiydvllealasg
subfamily_CG42327_pd Subfamily CG42327 1217-1372 5.4e-11 36.7 In-house 24-183 (319) alignment 
Range on Protein: 1217-1372
Range on HMM: 24-183/319.0
LLPRNHDKNRSMDVLPLDRCLPFLISV-DGESSNYINAALMDSH-KQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTA--QFCMQYWPEKTS
. .  .||.| ..|.||    . | .. | ....|..|. .  . . |. .. .| .| .. .||||.|.. .   .| | ..     . | .|.| | .
vPvtskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtket

G----CYGPIQVEFVSADIDEDIIHRIFRICNMARpqDGYRIVQHLQYiGWPAyRDTPPSKRSL
.     || |.| .   ....  .   . . .. .  .  | . |  |  |.   . | ....|
ldntslyGdilvtlkgrevkdryaistlllkrvdk..eesrelthywy.kwle.aevPaeeaal
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 1218-1458 1.3e-52 173.6 In-house 41-278 (315) alignment 
Range on Protein: 1218-1458
Range on HMM: 41-278/315.0
LPRNHDKNRSMDVLPLDRCLPFL-ISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQF--CMQYWPE--KTS
 . |. |||  ..||||.    | .  |   |.||||. . | ..  |.. .| ||. .| ||||.|.... ...||.....      | ||||.    |
etinfkknryknilPldsarvkleviddsPdsdyinasyiksvdddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrqywPdrkads

GCYGPIQVEFVSADIDEDIIHRIFricnMARPQDGYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKWQEQydgREGRTVVHCLNGGGRSGTFCAICS
  .| |.|| .| . | | ..| .    . |  . .| |   |. .||  . ..    ||||... .   ...   .|   .|||. | ||.| ...| .
vefGsikvellsleadtdgvarkl....vtrkseesrtvtqfqftewPd.kGvdkqtssllklikevkadngk...kefsllvhcsaGvGrtGvviside

VCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLS
| . |.... .|||..||.||...  .| | |.| |.|.. ||.| 
vvaqikrtrsvdvfnfvknlrakrpylvqteeeyafiydavledll
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 1218-1458 7.2e-50 164.6 In-house 25-269 (274) alignment 
Range on Protein: 1218-1458
Range on HMM: 25-269/274.0
LPRNHDKNRSMDVLPLDRCLPFLISVDG--ESSNYINAALMDS-HKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQF--CMQYWPEKT-
..... |||  ..|| ..    | | ..  | |.||||  .   ...  |.| || |||||||||||...  ... .||| ..  |.   | .|.|... 
vfgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaed

---SGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDgyriVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFC
   |. || ........   .|   | . . .. |...    |.|  |  ||  ...| . ..||..|.  |. .|. . . . .||||  | || | | 
yeiserygdveikvekiverndysvrklvlkylerers....vkhywytdWPd.hksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfi

AICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLS
||   .  .......||..||  || ..  ||.| |||......  .||.
aisiavrqlreeivvdvlkivcnlrldrGGmvqtseqyelihralclylk
subfamily_PTPN9_pd Subfamily PTPN9 1218-1457 3.9e-48 159.0 In-house 39-290 (297) alignment 
Range on Protein: 1218-1457
Range on HMM: 39-290/297.0
LPRNHDKNRSMDVLPLDRCLPFLISVDG-ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMD-T-AQFCMQYWP--EKTS
|. |  |||  ||| .|.   .| .||. | |.||||  .| .||. ||. || ||..|| ||||.|.. ..  .||   .  .    | ||||  |..|
lranleknrytdvlcydetrvvlakvdedeasdyinanfvdGykqkkafiatqGplkktvsdfWrmvWeqevlvivmttrvvergrlkcgqyWpleeess

GCYGPIQVEFVSADIDEDIIHRIFRICNMARPQdgYRIVQHLQYIGWPAYrDTPPSKRSLLKVVRRLEKWQEQY----------DGREGRTVVHCLNGGG
  .| ..|. |. .  ||  .|.. | |.   .   | | | |...|| |  .| |  |||.|..   . | .           . ..   ||||  | |
aefgdlsvsnveveeeedykvrvleiknvktee..srkvthfqflsWPdy.GvPssaaslldvlekvrekqalavkelgdewkghpsgPPivvhcsaGiG

RSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
|.|||...    . ..... .||.. ||.||. .. .. | |||.| |   ||| 
rtGtfitldiclsrleevgtvdvvetvkllrtqrafsiqtpeqyefcylavleya
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 1218-1458 1.4e-45 150.6 In-house 38-277 (281) alignment 
Range on Protein: 1218-1458
Range on HMM: 38-277/281.0
LPRNHDKNRSMDVLPLDRCLPFL-ISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVML-NEMDTAQF-CMQYWPEKT-SG
 . |  ||| ...   |     .  . . ....||||  ... |.......|| |.|.....||..|.... | .||. .|... .  | .|||... . 
adenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgykgekeyiatqgPvPaslvafWqmvweqkvsaivmvtreieagklkChrYWPddnsel

CYGPIQVEFVSADIDEDIIHRIFRIcnmARPQDGYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKWQEQYDGreGRTVVHCLNGGGRSGTFCAICSV
 || ..|.....   .  |.| |..    | .   | |..|.|. ||     | . . ||.  . ..| .|.        |.||  | ||.||. |.  .
kygdvtvkstaeeekatyierkfkl...eresgetreveqlaytaWPd.hGvPattkellefrkevlkltekktk..aplvihCsaGvGrtGtyialDrl

CEMIQQ-QNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLS
.. ... .. .||  .|. ||...  || |. ||.||| . |..|.
vkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldald
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 1219-1456 1.3e-14 48.5 In-house 45-278 (303) alignment 
Range on Protein: 1219-1456
Range on HMM: 45-278/303.0
PRNHDKNRSMDVLPLDRClpfliSVDGESSNYINAALMDSHKQPAAfVVTQHPLPNTVADFWRLVFDYNCSSVVM-LNEMDTAQFCMQYWPEKTSGCY--
 .| |||| .||. ||        |    | || |. .. . .  | ..|| ||. | ||||... . .   |.. | . .  ..  ..   .       
vknmdknrfvdvicldhs.....kvklsdssyihasyleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprnqdflkf

--GPIQV-EFVSADIDEDIIHRIFRICNmarpqDGYRIVQHL-QYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGReGRTVVHCLNGGGRSGTFCAIC
    |.| ||   .. .    ..  . |       |.   |. .|  ||       .   ..| . .|.    .|      ||   | | ||.|||. . 
eersirvgefkrvelgdgwvlkvlsvsn.....gdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysds.tptvymslsgcgragtfalfe

SV-CEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY
.    . ..|. .|. . ....|| .   |. | |. .|| .  |.
tahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaeh
subfamily_PTPRK_pd Subfamily PTPRK 1220-1455 7.4e-115 378.1 In-house 42-275 (314) alignment 
Range on Protein: 1220-1455
Range on HMM: 42-275/314.0
RNHDKNRSMDVLPLDRCLPFLISVDGE-SSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMdTAQF---CMQYWPEKTSGcY
 |..||||.|.|. ||...|||..||. ||.||||||.||.|.||||.|||.||..||.||||||.|.||.|.|||.|. ....   |..||||.|.  |
enreknrsgdilaydrsrvflitidgdpssdyinaalidsykrpaafivtqgPlqetvkdfWrlvydencasivmltel.vevgrvkClkyWPedtev.y

GPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAYrDTPPSKRSLLKVVRRLEKWQEQydgREGRTVVHCLNGGGRSGTFCAICSVCE
|.|.||.|..........||||....||.|...|.|...|..|||.. |.| |...|||.|||..|.||.   ..||.||||..|.||.|||.||..|..
gdikvelvetellaelvvrifrveklargqeeirevrqfqflgWpdh.dvPvsatgllklvrrvkksqee...eaGrivvhCsaGaGrtGtfiaidivld

MIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALE
||......|||..|||||..|.||||| |||||.|.|.||
mieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 1220-1456 2.6e-54 179.3 In-house 48-278 (315) alignment 
Range on Protein: 1220-1456
Range on HMM: 48-278/315.0
RNHDKNRSMDVLPLDRCLPFL-ISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKtSGCYG
 |..||| ..... |.  ..| .    . |.|.||...| ....  .. .| |....| |||||||..... .|||...     . . .|||.|    ||
enkqknryiniiaydksrvqlpllendphsdyvnanfidGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltnlvegekrkaekywpdk.kviyG

PIQVEFVSADIDEDIIHRIFricnMARPQDGYRIVQHLQYIGWPaYRDTPPSKRSLLKVVRRLEKWQEQYDgreGRTVVHCLNGGGRSGTFCAICSVCEM
.| |  .| .. ...  | .        .|  | |  |.|  ||   . | .  .|....|.  .....     |  |||| .| ||.|||... .| . 
kitvtrkseevnteytvrtl....svvfgdnirevvqlhytswp.dmgvpkytiplmnlirtvkqhhtnsv...gaivvhcsaGvGrtGtfitldavldq

IQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY
.. .|.|||..... .|.|. .||...|||.|.|.. || 
aeaenaidvynfitgvrqnrikmvqvaeqyqfiydallet
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 1220-1455 5.6e-27 89.5 In-house 2-237 (237) alignment 
Range on Protein: 1220-1455
Range on HMM: 2-237/237.0
RNHDKNRSMDVLPLDRCLPfLISVDGESSNYINAALMDS-HKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKT-SGCY
.|. |||  ..   | .   ..   | .|.||||. ...    |  .. .| || ..  |||..|.. .|| .|||  .     . | .|||.     .|
enkiknrygnivaydhsrv.vlkgagsgsdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

GPIQVEFVSADIDEDIIHRIFRICNMARpQDGYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKwQEQYDGREGRTVVHCLNGGGRSGTFCAICSVCE
| . | .   .   |   | . . .  . . . |...  |.  ||  |  |    .||.  ... . . ..  . |  ..||  | ||.| |  | ..  
gvltvslkkkeefsdytvrslllskrlt.lkevrlihqyqftswpd.rgvpqqtaallrfrkniin.rsphvsesgpwiihcsagvgrtgiflvidamlr

MIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALE
  ......|..  |... ...  ...| .|| |.... ||
qakekkvvdiynyvysieedrpyiiqtkdqyvfihqtile
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 1220-1454 7e-18 59.2 In-house 51-287 (310) alignment 
Range on Protein: 1220-1454
Range on HMM: 51-287/310.0
RNHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMD--TAQFCMQYWPEK-TSGCYG
..  |||  ||. || .   |        .|| |  . .    ..|...| ||  |. ||||..|.  . |...|  .       |. |||    .  ||
kymhknrysdvvcldtsrvklkidksryedyihanyvktnylrstficsqgplqhtiidfwrmifqeraesilllckvgeegrpkcvgywpslgvtetyg

PIQVEFVSADIDEDII-HRIFRICNMARPQDGYRI-V--QHLQYIGWPAYRDTPPSKRSLLKVVRRLEKwqeqyDGREGRTVVHCLNGGGRSGTFCAICS
 |.|  .|   .|  |      .     | |     .    .. | || . |.         | .||       . | |  ||||  | .| .. .|.  
cirvtnlsesseefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqrlla.....qvrhgpcvvhcsagkdrlyvvvalkl

VCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVAL
  . ... . .|. ...  |....   ..|  || ..  | .
kidkldrglkvdaeevktellksraiciqtelqyliidrvri
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 1220-1459 2.7e-15 50.9 In-house 42-278 (312) alignment 
Range on Protein: 1220-1459
Range on HMM: 42-278/312.0
RNHDKNRSMDVLPLDRCLpflISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKTS-----
. .| ||  ..   ||     ... |.   || | ..    .|  ||.|| || ||.. ||.|..   ..|...|  .  |... | .|  .  .     
kfkdlnrypniqcwdrgr...ftlagdenfyihanfvkictkperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdle

--GCYGPIQVEF-VSADIDEDIIHRIFRICNMARPQDGyrIVQHLQYIGWPAYrDTPPSKRSLLKVVRRLEKWQEqydgregRTVVHCLNGGGRSGTFCA
    |     |  .     . | ||....   |  |.    ..| |.  || .   | |  . |...  . | .          . ||  | ||.||.. 
dhrvyteycteieiggkskdkithrvlkvvvkatgqes..klnhyqwaswpdh.gmpdscdtalrllsavkkdkk.......pviahcsagvgrtgtlal

ICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS
| |.   ...    .| ..   ||....  |... || ..  . ||.| |
iesmiaalrhprkqnvkdsfvllrkdrarsvrvfpqyvyalrcvleflys
Y_phosphatase Protein-tyrosine phosphatase 1221-1455 4.5e-66 218.0 Pfam-A 1-235 (235) alignment 
Range on Protein: 1221-1455
Range on HMM: 1-235/235.0
NHDKNRSMDVLPLDRCLPFLiSVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTA--QFCMQYWP--EKTSGCYG
|..|||. |.|| |.    | . ....|.||||  ....|.. .|..||.||..|..||||.|........|||.. .    . | ||||  |..|  ||
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

PIQVEFV--SADIDEDIIHRIFRICNMARPQdGYRIVQHLQYIGWPaYRDTPPSKRSLLKVVRRLEKWQeqyDGREGRTVVHCLNGGGRSGTFCAICSVC
 |.|| .  . ....... | ... . ....   |.|..|.| .||  ...| |..|||...|..||..   . ..| .|||| .| ||.|||.|.  ..
dikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldill

EMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALE
|...... .||..|||.||... .||..||||.|.|.. ||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 1221-1455 4.5e-66 218.0 In-house 1-235 (235) alignment 
Range on Protein: 1221-1455
Range on HMM: 1-235/235.0
NHDKNRSMDVLPLDRCLPFLiSVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTA--QFCMQYWP--EKTSGCYG
|..|||. |.|| |.    | . ....|.||||  ....|.. .|..||.||..|..||||.|........|||.. .    . | ||||  |..|  ||
nkkknRykdilpydktrvkl.kgsegpsdYInAnyvkgykekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeesltyg

PIQVEFV--SADIDEDIIHRIFRICNMARPQdGYRIVQHLQYIGWPaYRDTPPSKRSLLKVVRRLEKWQeqyDGREGRTVVHCLNGGGRSGTFCAICSVC
 |.|| .  . ....... | ... . ....   |.|..|.| .||  ...| |..|||...|..||..   . ..| .|||| .| ||.|||.|.  ..
dikvelkekekedekeytlrklelkkkkees.ekrevkqlhytnWp.dhgvpespkslldlirkveksk...eaksgpvvVhCsaGvgRtgtfvaldill

EMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALE
|...... .||..|||.||... .||..||||.|.|.. ||
eqleaeeevdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 1221-1459 6.8e-55 181.3 In-house 51-286 (297) alignment 
Range on Protein: 1221-1459
Range on HMM: 51-286/297.0
NHDKNRSMDVLPLDRCLPFLISVDGE-SSNYINAALMDSHKQpaAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT-AQFCMQYWPEKTSGCYGPI
| .|.|  ..|| |.    | .|. . .|.|.||. . . |.   .. || | ..||||||..|.|.. | .||||. .   . | .||..|..  .| .
nfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh..rlittqmPmkatvadfWamvldeqvstivmlnddnerdkkcaryWsdkgvttfGdv

QVEFVSADIDEDIIHRIFRICNMArPqDGYRIVQHLQYIGWPAYRDTP-PSKRSLLKVVRRLEKWQEQYdgREGRTVVHCLNGGGRSGTFCAICSVCEMI
 |.  | .  |  |.| . . . . .    |.|.  |.. ||        | .||||..  ..|  .|    ||  .||||.| || | ...| ||   .
svvllsvsereGfikrelevtkgk.a.karrvvkqyqfveWPdkaverkdsassllklisevrkdfsqn..aegPllvhclaGvGrtgvlltidsvvaea

QQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLSS
.... .|.| .|| ||... ..| | |||||||.. ||.|.|
krekevdifglvkklrqerpylvqtkeqykfvyvavlealls
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 1221-1457 3.1e-53 175.6 In-house 43-276 (515) alignment 
Range on Protein: 1221-1457
Range on HMM: 43-276/515.0
NHDKNRSMDVLPLDRCLPFL-ISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTA-QF-CMQYWPE--KTSGCY
|. |||  ..||.|.    | .  |   |.|.||. . | .   |.. .| |.. .| ||||||...| . ..|....    .  | .|||.    |  .
nfkknryknilPydsvrvklevindnPhsdyfnasyipsfdndkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWPdkpgdsvkf

GPIQVEFVSADIDEDIIHRIFricNMARPQDgYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKWQEQYDgreGRTVVHCLNGGGRSGTFCAICSVCE
| |.|| || . . . | | .   .. . .| .| |   .. .||  . .|.  .||||... .   ..||       ..||. | || | ...| ||  
Gsikvelvsleactggikrkl...tvlkgdd.srtvtqfhfteWPd.kGvpkhtssllklikevkadhgqyt...hpliihcsaGvGrtGvvisidsvva

MIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
 ... ...|||..|. .|...  .| | ||| |.|.. ||.|
hakttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
0041856 (Phosphotyrosine protein) phosphatases II 1221-1457 2.3e-41 136.8 In-house 1-171 (182) alignment 
Range on Protein: 1221-1457
Range on HMM: 1-171/182.0
NHDKNRSMDVLPLDRCLpflisvdgeSSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNemdtaqfCMQYWPektsgcygpiqv
|.|||| .|.|| |. .          ..|||| |...   .  |..||.||..|||||.|.. .......|.|.       . .|||            
nldknrysdilpydhsr.........dldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt.......eelywp............

efvsadidediihrifricnmarpQDGYRIVQHLQYIGWPAYRDTPpsKRSLLKVVRRLEKwqeqydgREGRTVVHCLNGGGRSGTFCAICsvceMIQQQ
                        .. .| . ...|..|| .  ..   ..||. ... ..       ..|...|||  | ||.||..|.     .. ..
........................ellerlgiqylylpwpDhgvpd..ldelldfieevle.......eggpvlVHCsaGvgRtgtlvaay....lmkkl

NiIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
. ......||..|. ...||.|..|| |.. ..||.|
g.vsleeavklvrsrRpgmvitpnqyfflqlallell
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 1221-1456 1.2e-38 127.5 In-house 38-276 (287) alignment 
Range on Protein: 1221-1456
Range on HMM: 38-276/287.0
NHDKNRSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVML-NEMDTAQF-CMQYWPEKTSG-CYGP
.  |||  ||||.|    .|       |.||||  . |...  ||...| |.. || ||||.|.. . .||...  |.. |.  | .||||.      | 
avkknryadvlPiddtrvllsaegelGsdyinanyvasytddeafiaaqgPiaatvrdfwravletrsasvitmtreveearlkcykywPerevPmrvGG

IQVEFVSADIDE-DIIHRIFRICNMARpqDGYRIVQHLQYIGWPAYrDTPPSKRSLLKVVRRL-EKWQEQYDGRE-GRTVVHCLNGGGRSGTFCAICSVC
  |  .. || | .   | .|. ..       |.|. |... ||.    .|.  .|.. |    .. . . |. | |  |||.  | ||||.. |.  . 
ysvvlldydikePeygvralrlidlet..rearvvkqldllswPdk.vlaPtavglirfvldvkqhielardasevGPlvvhddvGiGrsGillatlvlv

EMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY
.. ..   .||  .|  ||. .  .| .  |....||    |
srledlGrvdvaavvirlreyraalvqavvqlrllyealvty
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 1221-1456 3.8e-28 93.0 In-house 56-282 (290) alignment 
Range on Protein: 1221-1456
Range on HMM: 56-282/290.0
NHDKNRSMDVLPLDRCLpfLISVDGESSNYINAALMDSHKqpAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKTSG--CYG
.  |||  ||   |.    .|  ||   .|. |  ..  |  | |..|| .| .|| |.||.| . . . .||| |.  |    | ||.|||      .|
efkknrykdvvcndktr..vilkdGydGdyvhanyvkGlk..amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGevltfG

PIQVEF-VSADIDEDIIHRIFRICNMARPQDgyRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKwqeqydgREGRTVVHCLNGGGRSGTFCAICSVCE
 | |    . | |..||.... . ..   ..   ...||. . ||  .  . |. .||...| | |         |  ||||  | ||.||| ||    .
eitvlcseeddkdaniikktlsvrdkdsGke..hklkhlkikswpd.ksvalstlallrtlrilrk.......asGpvvvhcsaGiGrtGtfvaievglq

MIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY
.. .   .|.  .|..||| . | |.   ||  . |. |..
illdGkeldlldlvralrnsrlnsvqvdiqylalveilldl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 1221-1455 6.2e-28 92.6 In-house 7-238 (239) alignment 
Range on Protein: 1221-1455
Range on HMM: 7-238/239.0
NHDKNRSMDVLPLDRCLPFLISVD-GESSNYINAA-LMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMD--TAQFCMQYWPEKTSgCYG
|. |||  ...  |.    |  .     |.||||. | |    | |.. ||  .  .  ||||....     .|||  .     . | ||||. ||  | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kyc

PIQVEFVSADIDEDIIHRIFRICNMARPQDGYriVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKwqEQYDGREgRTVVHCLNGGGRSGTFCAICSVCEM
 ..| .  ...  | | | | . .. . .. |  | . ..  ||  .  |    ..| . |.. |  .   |     |.||  | ||.|.|  | ..   
nlrvtlrktevfadyiirtfvmsqvgqteery..vyqyhftvwpd.kgvpqyatavlglrrkitk..dslpgar.pwvihcsagvgrtgaflvidamlrq

IQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALE
 ..|. .|.|  ||..|...  ||.| ||| |..   ||
akkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 1221-1454 7.6e-28 92.3 In-house 8-238 (239) alignment 
Range on Protein: 1221-1454
Range on HMM: 8-238/239.0
NHDKNRSMDVLPLDRCLPFLISVD-GESSNYINAA-LMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMD--TAQFCMQYWPEKTSgCYG
|. |||  ...  |.    |  .     |.||||. | |    | |.. ||  .  .  ||||....     .|||  .     . | ||||. ||  | 
nkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdsts.kyc

PIQVEFVSADIDEDIIHRIFRICNMARPQDGYriVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKwqEQYDGREgRTVVHCLNGGGRSGTFCAICSVCEM
 ..| .  ...  | | | | . .. . .. |  | . ..  ||  .  |    ..| . |.. |  .   |     |.||  | ||.|.|  | ..   
nlrvtlrktevfadyiirtfvmsqvgqteery..vyqyhftvwpd.kgvpqyatavlglrrkitk..dslpgar.pwvihcsagvgrtgaflvidamlrq

IQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVAL
 ..|. .|.|  ||..|...  ||.| ||| |..   |
akkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 1221-1457 2.6e-19 64.1 In-house 48-287 (305) alignment 
Range on Protein: 1221-1457
Range on HMM: 48-287/305.0
NHDKNRSMDVLPLDRCLPFLisVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKTSGCY---
...|||  ||  ||.    |        .|| |  . .  .|  |. || || .| |||| . .. .  .. || ..    |. |..|.. |        
eagknrykdvgcldnnrvkl..egpwpheyihanyvstptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvlefe

---GPIQVEFVSAD---IDEDIIHRIFRI-CNMARPQDGYRIVQHLQYIGWPAyRDTPPSKRSLLKVvrrLEKWQeqydGREGRTVVHCLNGGGRSGTFC
     |.| | |.    . .|   .. .    .  |    | |.|  .| ||  |  |..  ..|..   ||| .       | .||||  | ||.|.  
ekgqkisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpd.rgvpaadlailel...lekar....pskgpivvhcsagigrtgsvv

AICSVCEMIQQQNII-DVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
 .  ... . . .|| |  .|.. .|... | ..| .|| ||..| |.|.
mleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfvhqvilnyf
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 1222-1457 2.1e-21 70.9 In-house 56-289 (305) alignment 
Range on Protein: 1222-1457
Range on HMM: 56-289/305.0
HDKNRSMDVLPLDRCLPFLIsvDGESSNYINAALMDSHKQPA-AFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNE-MDTAQF-CMQYWPEKTS---GCY
  |||  ||   |. .  |   .   |.|| |  .     |   |...| || .|. .|| .| . .   .|||   ... .. | ||||          
itknryqdvpcqdqsavkld..kpspsdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqywpaaqgeklelk

GPIQVEFVSAD--IDEDIIHRIfRICNMARPQDGYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEkwqeqydGREGRTVVHCLNGGGRSGTFCAICSV
. | || ||    .. |   .|  . |..   |    |.|||.  ||  |  || | . |...  .        | .   ||||  | ||.||  ||  .
sgivvenvsgskpmerdaeiqi.tllnltysgdqkmsvrhlqwtewpd.rgvppckltslellsair.......gskvpivvhcsagigrtgtivaieyi

CEMIQQQ-NIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
 | | .. .   . ..||.||....  ...  || |.. | |.|.
lekiaenkpcppmpelvkalrdqrafsiqndvqylfihrvmlnyf
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 1222-1448 4.8e-21 69.8 In-house 51-272 (301) alignment 
Range on Protein: 1222-1448
Range on HMM: 51-272/301.0
HDKNRSMDVlPLDRCLPFLISVDGESSnYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKTSGCY--GP
.||.|   | | .      . |||.    | |  .... .|  |..|| ||.||  ||| ..  |.   .||| .   .. . | .| | |.|     | 
kdkhryptv.PckPstavevivdGkrv.PihanwiptsGhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigr

IQVEFVSA--DIDEDIIHRIFRICNMARPQDgYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKwqeqydgREGRTVVHCLNGGGRSGTFCAICSVCE
 ... ..    ....|..| ... . ..  .  | | | ||  |.. |..| |.  | ...  . |        |   |||| .| ||| .| .   .  
fkikiknkelilnkkiskrtlevedstgkfa.trtvthyqysewtd.rgvPkshaelfdlmelvkk.......sekPivvhcsaGiGrsvafigteylar

MIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKF
 .. .. |.. . .| ||... | | | .|  .
eveadptieltealkhlrehrwngvqtnsqlyw
subfamily_eak_pd Subfamily eak 1224-1361 6.2e-09 29.7 In-house 55-191 (332) alignment 
Range on Protein: 1224-1361
Range on HMM: 55-191/332.0
KNrSMDVLPLDRCLPFLISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWPEKT--SGCYGPIQ
.|  ....| || |  | |   .   ||||.|..  .    ...|  .  . |  ||..|.. .  ..|.| |      .   .|.|.||     .| ..
rn.vvkivpydrylvrltssqlnrlGyinaslaefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyfpdktreelkfGild

VEFVSAdIDEDIIHriFRICNMARPQDGYRiVQHLQYIGWPA
||  .  . ..|..  .|   . .  . .| |.| .. ||  
verkef.vkrnile..trllelskGnethr.vlhykvfGwte
0046846 (Phosphotyrosine protein) phosphatases II 1239-1458 1.9e-36 120.8 In-house 3-174 (176) alignment 
Range on Protein: 1239-1458
Range on HMM: 3-174/176.0
FLISVDGESSNYINAALMDSHKqpaaFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFC--MQYWPEKTSGCYgpiqvefvsadidediihrif
...........|||| |.....    ...||.|||.|.|||.......... ||.|.|.   ...  ..|||| ..  .                     
lrllgldldldyinanlilgsr....piatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi.....................

ricnmarpqdgyrivqHLQYIGWPAYrDTPPSkRSLLKVVRRLEKWQEQYdgreGRTVVHCLNGGGRSGTFCAicsvCEMIQQQNIIDVFHIVKTLRNNK
                . ....|| . ..|.. . ||.... .......     |...|||  | ||.||..|    . ... .. ..|.......|. .
................qylhlpwpDh.gvpdl.elllellefirealkeg....gpvlVHCsaGigRtgtlva....ayllelekglsveealalvreqR

S-NMVETLEQYKFVYEVALEYLS
. ..|.| |||.|.||..|..|.
plgavqtpeQyrflyefellllk
0044763 (Phosphotyrosine protein) phosphatases II 1241-1457 1.6e-24 81.9 In-house 10-171 (178) alignment 
Range on Protein: 1241-1457
Range on HMM: 10-171/178.0
ISVDG-ESSNYINAALMDSHkqpaaFVVTQHPLpntvADFWRLVFDYNCSSVVMLNEMDTAQF--CMQYWPEKTSgcygpiqvefvsadidediihrifr
... | |.| ||||  .. .     . ....|     ||...|. .......|.|.| .   |  | .||||...                         
snleglersdyinaseilpg.....lylgslpp....addlellkelgithivnlteelelgflkcdpywpeeag.........................

icnmarpqdgyrivqhLQYIGWPAYRDTPPS-KRSLLKVVRRLEKWQEqydGREGRTVVHCLNGGGRSGTFCaicsVCEMIQQQNIiDVFHIVKTLRNNK
                .||. .|   ...|.  . .|..|. .|....    ..|...|||  | |||||..    .. .. .... ....... .|. .
................iqylhipipDhgvpdllehflefvefieeald...ekggpvlVHCsaGvgRsgtlv....aaylmkklgl.sleeaielvrerR

SnMVETLEQYKFVYEVALEYL
. .|.. .|....||..|..|
p.ivpnpgqlrqLyefelrll
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 1241-1457 8.3e-22 72.5 In-house 60-271 (288) alignment 
Range on Protein: 1241-1457
Range on HMM: 60-271/288.0
ISVDGESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKTsGCYGPIQVEFVSADIDEDIIHRIFRI
. .. ..  ||.| .. |.| .  .. .| ||  |.  .|..... .   .|||.|.     .   .|.| |  |    |.        . . |... ..
vklsddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPskl.Gekarigrlctvvkkkradidklvkv

CNM--ARPQDGYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKWQEqydgregRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNK
  .   .. .   ||..| .  |.     | .  | |... .|.. |.         |||. .| ||.||.  |  . |... .. . . .... ||...
sllriskegeekvivkilhlleWdd.dgvPenylsplrllevlkslqk.......PivvhssaGvGrtgtlililialeslrlddflgirsllaklreer

SNMVETLEQYKFVYEVALEYL
 . ..|  || .|. . ||.|
fkaiqtemqylyvhrcvleel
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1245-1310 2e-06 21.4 In-house 87-156 (349) alignment 
Range on Protein: 1245-1310
Range on HMM: 87-156/349.0
GESSNYINAALMDSHK--QPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQF--CMQYWPEK
|   .||||  .   .      .. || ||| || ||....   .   |. ||. .  ..  | .|| | 
gklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkelslekcdiywqel
subfamily_PTPRD_pd Subfamily PTPRD 1246-1460 6.2e-64 211.6 In-house 74-284 (564) alignment 
Range on Protein: 1246-1460
Range on HMM: 74-284/564.0
ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQ--FCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRIcNMAR
|.|.||||  .|..... |.. ||.||..|..||||.|...|.|..|||...   .   | .|||||..  || ..|....    .|.. | |.. ....
egsDYINAsfidgyrkrkayIAtqgPlaetiedFWRmvweqnsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeeeladyeirtfkl.kkkk

pQDGYRIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKWQEqydGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETL
 ..  | |.. ... ||  .. | | .|||...|. ....|     .| .|||| .| ||.|||..| .. | |.... .|.. .||.||...  ||.| 
.ssesreVrqFhFtsWPd.hgvpesatslLdlirkvralne...pdagPivVhCSaGVGRTGtfividamlerikeektvDiyqyvkalrkqRnamVqte

EQYKFVYEVALEYLSSF
||| |..|. ||.|...
eQYiFiheailealacg
0043147 (Phosphotyrosine protein) phosphatases II 1246-1451 9.4e-33 108.7 In-house 3-155 (172) alignment 
Range on Protein: 1246-1451
Range on HMM: 3-155/172.0
ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMdtaqfcmqywpektsgcygpiqvefvsadidediihrifricnMARPQ
|.|.|||| ..| .  |  |..|| ||.||.|||||.. ..... .|.|.|                                            .  |.
egsdyinasyldlyyipdrfiatqgplrntladfwrmlkelgithivnltel...........................................lydpe

DGYRIVQHLQYIGWPAYRDTppSKRSLLKVVRRLEKWQeqYDGREGRTVVHCLNGGGRSGTFCAICSVCemiqqQNIiDVFHIVKTLRNNKSNMVETLEQ
. .| . ...|..|| .  .  . . ||.... .....     ..|...|||  | ||.||..|.  ..     ... .....|...|. ....|.. .|
llerlgiqylylpwpDhgvp..llellleflefidell..alspggpvlVHCsaGvgRtgtlvaaylml.....lgl.sleeavalvrekRpgavqnpsq

YKFVYE
|.|.|.
yrflyy
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1246-1310 2.5e-08 28.0 In-house 81-153 (350) alignment 
Range on Protein: 1246-1310
Range on HMM: 81-153/350.0
ESSNYINAALMDSH----KQPAAF--VVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTA--QFCMQYWPEK
....||||  .       .. . |  . || |||.|| ||.....  .   ...|.. .    . | .||.| 
stnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvilsltsdvelnlekcyrYWqeg
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 1246-1297 4.9e-08 26.9 In-house 68-119 (347) alignment 
Range on Protein: 1246-1297
Range on HMM: 68-119/347.0
ESSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEM
.. .||||. .   .    ...||.|||.|| |||..|.  . . || . | 
dvetyinashikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifep
0051429 (Phosphotyrosine protein) phosphatases II 1247-1458 1.8e-36 121.6 In-house 3-226 (272) alignment 
Range on Protein: 1247-1458
Range on HMM: 3-226/272.0
SSNYINAALMDSHKQ---PAAFVVTQHPLPNTVADFWRLvFDYNCSSVVMLNEMD--TAQFCMQYWP------------EKTSGCYGPIQVEFVSADIDE
 |.||||  ..   .   | ..  ...|||.|.||||||  .......|.| . .   .. | .|||            . ..  || . | ..|  . .
lsgyiNardvggygrvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseelll

DIIHRIFRICNMARPQDGyRIVQHLQYIGWPAYRDTPPSKRSLLKVVRRlekwqeqydgrEGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIID-----
|.|.| ... ..  .... | | ||.|..|| .   . . ..||.....           .|. .|||  | .|.||..|.  . . .  . |.|     
dyilrellltlllsagea.revmhlhytdwpdhgvpqeallellellld...........ggpvlvHCsaGkdRTGtvvallllllgvsletivddYllt

---VFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLS
   ....|. ||    ..|.| |||.|.||..||.| 
nlyleeaveelraqrpgavqteeqylflyeallellr
0051082 (Phosphotyrosine protein) phosphatases II 1247-1453 2.8e-24 80.8 In-house 2-149 (151) alignment 
Range on Protein: 1247-1453
Range on HMM: 2-149/151.0
SSNYINAALMDSHkqpaaFVVTQHPLPntvaDFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTsgcygpiqvefvsadidediihrifricnmarpqd
 |.|||.  ....     . ....||.    ||..|. .......|.|.. .  ..| .|.||                                     
lsdyinfsyvtgg.....lyrsggpla....dflellkelgiktivnlrseeergycpeylpelg...................................

gyRIVQHLQYIGWPAYrDTPPSKRSLLKVVRRLEKwqeqydGREGRTVVHCLNGGGRSGTFCAICSVCEMiqqqniIDVFHIVKTLRNNKSNMVETLEQY
  . | |.....||.. ..| |  ..|.... |..       ..| ..|||  | ||.||..|.  ....      .... ... .|    ..| . .|.
..ievlhipildwpdp.glplsfdavleflellld......kkngpvlvHCsaGkgRTGtlvalylmllg......vsleealeeyrlkrpgvvqpnqqf

KFVYEVA
 |.. . 
lfqlfal
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 1247-1310 3.8e-06 21.2 In-house 12-72 (130) alignment 
Range on Protein: 1247-1310
Range on HMM: 12-72/130.0
SSNYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQfcmQYWPEK
  .|||| ..    . | .. ||||| .|  |||.....     .|.|  ..  .   .|||. 
gntyinasfvGllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveeed...eywpds
0036282 (Phosphotyrosine protein) phosphatases II 1248-1451 2.4e-37 123.6 In-house 2-164 (174) alignment 
Range on Protein: 1248-1451
Range on HMM: 2-164/174.0
SNYINAALMDSHKQPAAFVVTQHPLPntvadFWRLVFDYNCSSVVMLNEMDTAQ--FCMQYWPEktsgcygpiqvefvsadidediihrifricnmaRPQ
|.||||  .| .  .  ....|.||.     ||..........||||.|    .   | .||||                                 ...
sdyinaspldlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe.................................lre

DGYRIVQHLQYIGWPAYRDTPPSKrsLLKVVRRLEKWQEQydGREGRTVVHCLNGGGRSGTFCAICSVCEMIQqQNIIDVFHIVKTLRNNKSNMVETLEQ
| .| . ...|..|| .   . |.  ||..|...|.....  ...| ..|||  | ||.||..|.  .. ..  .. .|....|..||. ...||.| .|
dlerlgiqylylpwpDhgvpdlsi..llefvkfveealse..dpggpvlVHCsaGvgRtGtlvaaylmlrgll.eslvdaldlvrelRlqrpgmvqtpsQ

YKFVYE
|.|.|.
yrflyy
subfamily_egg_pd Subfamily egg 1249-1454 7.3e-20 65.8 In-house 69-267 (307) alignment 
Range on Protein: 1249-1454
Range on HMM: 69-267/307.0
NYINAALMDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSG--CY--GPIQVEFVSADIDEDIIHRIFRICNmARP
..| |  .. .     |...| || ||| ||||.||  ..  .|||.    .. |  |||   |    .  | ...| .  |   | . |. ..     .
dfihanrvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkeserceyywpkaesdslvtvpGslrienlkvdskadplfrvtklkl.vGg

QDGYRIVQHLQYiGWPAYRDtppsKRSLLKVVRRLEKWQEqydgregRTVVHCLNGGGRSGTFCAI-CSVCEMIQQQN-IIDVFHIVKTLRNNKSNMVET
.|  | ..| |.  .    |      | |.|.|.| .  .        .||.. .|  ...|. ||  .......       | . |. || ..   ||.
ddeerflehwqg.dvnnssd....vysplrvlrklrnlsk.......pvvvqdilGvskaatlvaieiallsllrGpitkslvlravvflrlrrrlsves

LEQYKFVYEVAL
  .| ||| . |
vllylfvyrlvl
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 1249-1454 1.3e-13 45.7 In-house 47-256 (290) alignment 
Range on Protein: 1249-1454
Range on HMM: 47-256/290.0
NYINAALMDsHKQPAAFVVTQHPLPN-------TVADFWRLVFDYNCSSVVMLNEMDT-----AQF-CMQYWPEKTSG--CYGPIQVEFVSADIDEDIIH
.|| |  .    .  ....|| |. .       |. .|| .. . .  .|||| |..       .| | .| ||.  .   .. ..|.  |   ..|...
dyiHAnrvt.cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkgltvkCkskekeddvet

RIFRICNMARPQdgYrIVQHLQYIGWpAYRDTPPSKRSLLKVVRRLEKwqeqydgREGRTVVHCLNGGGRSGTFCAICSVCEMIQ-QQNIIDVFHIVKTL
|   .    . .  .  |.| .. ||  .. .......||.... ...       ..   .||| .|  || .. ||   . .|  ... . .  ..|.|
Relvvkfddeee..f.tvtHsllkgW.nklnvqedtktllsliqkvka.......sktpvivHcvdGiSrsAalaaiilgyQkiaetsgsvkledvlkal

RNNKSNMVETLEQYKFVYEVAL
|... ... . ... ||  ...
rkqralaitsalelafvdagiv
0049260 (Phosphotyrosine protein) phosphatases II 1256-1451 1.9e-28 94.5 In-house 2-144 (152) alignment 
Range on Protein: 1256-1451
Range on HMM: 2-144/152.0
MDSHKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDT--AQFCMQYWpektsgcygpiqvefvsadidediihrifricnmarpqdgyrivqh
.| ...| .|. ||.|.|||.|||||.. ..... .|||.| .     .| ||.                                              
idgyampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi..............................................

lQYIGWPAYRDTPPSKRSLLKVVRRLEKWQeqYDGREGRTVVHCLNGGGRSGTFCAICSVCemiqqqNIIDVFHIVKTLRNNKSNMVETLEQYKFVYE
 ||. .|   ...|.   ||. . .. ..   .  ..|...|||  | ||.||..|.  ..      . ......|. .|. ....|.. .|..|.||
.qylhlpwpDhgvpdlsqlllflllfiekl..aldkggpvlVHCsaGvgRtgtlvaaylml......lgvsleeavalvrekRpgavpnpgqlrflye
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 1259-1452 5.4e-20 66.4 In-house 1-199 (199) alignment 
Range on Protein: 1259-1452
Range on HMM: 1-199/199.0
HKQPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQF--CMQYWPEKTS--GCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHL
||    ...||||| .|.||||..|..     .||.|. .  .      |||   |  | || . |   .     |     . ..| .      | . | 
hkgqrryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishy

QYIGWPAyRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAIC--SVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEV
|.  |   . ||     .  ||   |  .   . ..   .||| .| | .| | |.          .  ..|.| . | ||. .  .. .|..|.|.|.|
qftswke.kttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1261-1321 5.1e-14 46.4 In-house 234-294 (440) alignment 
Range on Protein: 1261-1321
Range on HMM: 234-294/440.0
QPAAFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTaQFCMQYWPEKT-SGCYGPIQVE
.  ||. || ||  || |||||| ||. |...|||...  . |  ||| .| |  .||. | 
kknafiatqmpldstvldfwrlvhdyristiimlnqlnd.ktcsiywpvntrsvtfgpftvg
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 1264-1452 1.1e-19 65.4 In-house 5-198 (198) alignment 
Range on Protein: 1264-1452
Range on HMM: 5-198/198.0
AFVVTQHPLPNTVADFWRLVFDYNCSSVVMLNEMDTAQF--CMQYWPEKTS--GCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGW
 ...||||| .|.||||..|..     .||.|. .  .      |||   |  | || . |   .     |     . ..| .      | . | |.  |
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PAyRDTPPSKRSLLKVVRRLEKWQEQYDGREGRTVVHCLNGGGRSGTFCAIC--SVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEV
   . ||     .  ||   |  .   . ..   .||| .| | .| | |.          .  ..|.| . | ||. .  .. .|..|.|.|.|
ke.kttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfiyqv
subfamily_hpo-7_pd Subfamily hpo-7 1265-1449 2.1e-11 38.2 In-house 42-219 (263) alignment 
Range on Protein: 1265-1449
Range on HMM: 42-219/263.0
FvvtqhpLPNTVADFWRLVFDYNCSSVVMLNEMDTA--QFCMQYWPEKTSGCYGPIQVEFVSADIDEDIIHRIFRICNMARPQDGYRIVQHLQYIGWPAY
.      | .|.. |.. .   . . |||| ..  .  . | .|.| .  .     .|. ..... .|.. .   . ..   .   . |.| .| ||.. 
l......lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqsdvllktlellstlgeKkkthtvkhysykgWiek

RDtPPSKRSLLKVVRRLEKWQEqydgregrTVVHCLNGGGRSGTFCAICSVCE-MIQQQN-----IIDVFHIVKTLRNNKSNMVETLEQYKFV
.| |   |. |....   . ..         |||| .|.|||  |  . .|   ||.. .      .|   ... ||....  ..|  |  | 
nd.pelareilnilkvarnsks........lvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafs
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 1269-1447 1.2e-08 28.8 In-house 97-278 (302) alignment 
Range on Protein: 1269-1447
Range on HMM: 97-278/302.0
QHPLPNTVADFWRLVFDYNCSSVVMLNEM--DTAQFCMQYWPEKTSGC--YGPIQVEFV--SADIDEDIIHRIFR-----ICNMARPQDGYRIVQHLQYI
  |  .|.  .| |. .|| . || | ..  |  . | .|. .|  |   .|   |. |    |..|    . |.     | |  . ..  . |. |.. 
ivpkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafs

GWPAYrDTPPSKRSLLKVVRRLEKWQEQydgregrTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYK
.|| .  .|    . |....  | ....        .||| .| ||.||. ||    .. ..... |. .||. .|. .   | . .|  
awpdh.Gapkeaytaldilkfcesykkn.......vlvhcsaGvGrtGtlvaikyGiqlcskkkvtdllsivlpvrqcryGavqdeqqli
subfamily_Cele-PTP-5_pd Subfamily Cele-PTP-5 1275-1458 7.3e-06 18.8 In-house 130-310 (346) alignment 
Range on Protein: 1275-1458
Range on HMM: 130-310/346.0
TVADFWRLVFDYNCSSVVMLNEMDTAQFCMQYWPEKTSGCY---GPIQVEFVSADIDEDIihRIFRICNMARPQDGYRIVQHLQYIGWPAYrDTPPSKRS
 | ||| .... .   | ..   |  .       .   | |   | . ..   ||.  |   . . |  .   .    |.|  ..  |    . ||    
fvedfwymiyqeqihlvylmvpddklkntttslfndenggyqytgkmfinnrradvsgdp..keytievlpegnsdsvicqvhhhapwkhl.qqppktlp

LLKVVRRLEKwqEQYDGREGRTVVhCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLS
..|.. ..    |.     |  ||  | | ||. .|       . ...    ... |.|......   ||.. ||  .| . ..|..
iikmihqfls..ekqvqnagvcvv.slfgcgracsfigalyainqlnngiepniceimknikqqrpggvesfaqyasiyaivfdyia
PTEN_1 1320-1409 2.6e-07 25.7 In-house 53-149 (196) alignment 
Range on Protein: 1320-1409
Range on HMM: 53-149/196.0
VEFVSADIDEDIIHRIFRICNMARPQDG----Y----RIVQHLQYIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDGrEGRTVVHCLNGGGRSGTFCA
...|.|| |.   . |. ..|..   .     |    .. ....|.  |   ...|| ..|........ |  . .  ..  .|||  | ||||| .|
lkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpn.gnvVlVHCkaGlgRsGtvva
0048076 (Phosphotyrosine protein) phosphatases II 1333-1456 7.4e-19 63.3 In-house 28-142 (145) alignment 
Range on Protein: 1333-1456
Range on HMM: 28-142/145.0
HRIFRICNMARP-QDGYRIVQHLQYIGWPAYrDTPPSKRSLLKVVRRLEKWQEQydgrEGRTVVHCLNGGGRSGTFCAICsvceMIQQQNiIDVFHIVKT
. | .. |...  .. .| . ...|..|| . ..|.. . ||.... .|.....    .|...|||  | ||.||..|..    .. ... ........ 
lgittvlnltselellerlgiqylylpwpDh.gvpdllellleflefieealke....ggpvlVHCsaGvgRtgtlvaay....lmlllg.vsleealel

LRNNKSNMVETLEQYKFVYEVALEY
.|.  ...|.. .|..|.||. ||.
vrsqrpgavpnpgqlrflyefelel
0048179 (Phosphotyrosine protein) phosphatases II 1333-1451 2.4e-17 58.5 In-house 28-139 (144) alignment 
Range on Protein: 1333-1451
Range on HMM: 28-139/144.0
HRIFRICNMARPQDGYRI---VQHLQYIGWPAYrDTPPSKRSLLKVVRRLEKWQEqydgREGRTVVHCLNGGGRSGTFCAICsvceMIQQQNiIDVFHIV
. |  ..|.. . . .     . ......|| . ..|..   ||.... .|...|    ..|...|||  | ||.||..|..    ..  .. .......
lgittvinlteeyepefleregiqylhlpwpDh.gvpdllellleflefieeale....eggpvlVHCsaGvgRtgtlvaay....lmkklg.lsleeal

KTLRNNKSNMVETLEQYKFVYE
. .|.  ...|.. .|..|..|
alvrsrrpgavpnpgqlrfLle
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 1348-1458 1e-20 68.5 In-house 277-386 (392) alignment 
Range on Protein: 1348-1458
Range on HMM: 277-386/392.0
YRIVQHLQYIGWPAY-RDTPPSKRSLLKVVRRLEKWQEqyDGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQY
   |   |. ||| .  |  .  |||||..| .    .  . .|   .|||| | ||.| ||.       | . . .|.|  || || .. ..|.| |.|
shtvtqyqfhgwpkhgsdqqsgarsllkliravkgstn..skkefsilvhclsgagrtgvfctameciaqiaegdsvdifqtvkilradrmqfvqteeey

KFVYEVALEYLS
 |||.|  ||| 
afvydvireylh
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 1349-1457 2.5e-15 50.7 In-house 89-194 (440) alignment 
Range on Protein: 1349-1457
Range on HMM: 89-194/440.0
RIVQHLQYIGWPAyRDTPPSKRSLLKVVRRLEKWQEQydGREGRTVVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKF
| ... .| |||  .  |     .||... ... ||.    .|  .|||  | ||.|   |. |.    .. . ||.| .....|||. .||.| ||| |
rtlkqyhyqgwpd.kgvpkfagpvlkmiqdvnesqek..agngpllvhcsagagrtgviiavdsilreakrsdqidifsfinsmrnnrpqmvqtpeqyaf

VYEVALEYL
|.|. || |
vheavlegl
PTPc_DSPc_SM00012 1351-1455 2.4e-26 87.3 In-house 2-105 (105) alignment 
Range on Protein: 1351-1455
Range on HMM: 2-105/105.0
VQHLQYIGWPAYrDTPPSKRSLLKVVRRLEKWQEQYDGrEGRTVVHCLNGGGRSGTFCAICSVCEMIQQQ-NIIDVFHIVKTLRNNKSNMVETLEQYKFV
|.|..| |||    .| .  |.|...| ..|.... .  .. .|||| .| ||.|||.|.. ........ . .|.| ||| ||. ...||.|.||| |.
vkhyhytgwpdh.gvPeesdsilellravkknknkses.skpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfl

YEVALE
|.. ||
yralle
0038934 (Phosphotyrosine protein) phosphatases II 1354-1447 7.9e-08 27.7 In-house 80-167 (194) alignment 
Range on Protein: 1354-1447
Range on HMM: 80-167/194.0
LQYIGWPAYRD-TPPSKRSLLKVVRRLEKWQEQydGREGRTVVHCLNGGGRSGTFCAICSVCEmiQQQNIIDVFHIVKTLRnnkSNMVETLEQYK
..|. .|   | |.||   ||. .. .... ..    .|  .|||  | ||.||..|   ..   .. .  .  ....  |    ..... ....
ieylklpfpddgtvPsleillrfldlvdeflne..dpggvvaVHCkaGlgRtGtlvaaYLiyr..lgmsaeeAialfrekR...pgaipnqdyle
subfamily_PTEN_pd Subfamily PTEN 1356-1450 1.2e-06 23.6 In-house 82-173 (184) alignment 
Range on Protein: 1356-1450
Range on HMM: 82-173/184.0
YIGWPAYRDTPPSKRSLLKVVRRLEKWQEQYDgrEGRTVVHCLNGGGRSGTFCAiCSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVY
 . .|   ..||.   | ..|. .||| |. .  .   ||||  | ||.|.  . . . .. . ..  .. .. .. | .... |    | ..|.
vavypfdDhnppplelleeivediekwleedk..knvvvvHCkaGkGRtGvliv.ayllkslllekaeealelfaeaRtknkkgvtiPsqrRYve
subfamily_DSP23_pd Subfamily DSP23 1365-1451 2.4e-06 22.3 In-house 63-140 (148) alignment 
Range on Protein: 1365-1451
Range on HMM: 63-140/148.0
TPPSKRSLLKVVRRLEKWQEqydgREGRTVVHCLNGGGRSGTFCAicsvCEMIQQQNIIDVfHIVKTLRNNKSNMVETLEQYKFVYE
.||.   . . || .|. .|    ..    |||| | ||.||. |    | .......    . .  .|. .   |||.|| | |..
hppaleqvvefvrvveeaee....kneavsvhcllgrgrtgtmla....cylvkerklaaa.eaiaevrrlrpgsvetveqeklvrd
subfamily_CG42327_pd Subfamily CG42327 1389-1456 9.6e-11 35.9 In-house 246-314 (319) alignment 
Range on Protein: 1389-1456
Range on HMM: 246-314/319.0
REGRTVVHCLNGGGRSGTFCAICSVCEMIQQQ-NIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALEY
. |  |||| .| ||.|.  |     . ...  . .|. ..|  .|..... | | |||.|.| |. ||
sqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykvlsey
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 1391-1457 1.3e-07 25.7 In-house 263-344 (350) alignment 
Range on Protein: 1391-1457
Range on HMM: 263-344/350.0
GRTVVHCLNGGGRSGTFCAICSVCE------MIQQQ-NIID--------VFHIVKTLRNNKSNMVETLEQYKFVYEVALEYL
   .|||  | || ||.... |. .      ..... . .|        .. ||. ||. . .|| .|.|. |.|| .| | 
spilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYeallfyf
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 1393-1458 3.5e-07 23.9 In-house 268-345 (349) alignment 
Range on Protein: 1393-1458
Range on HMM: 268-345/349.0
TVVHCLNGGGRSGTFCAICSVCE---MIQQ-QNIID--------VFHIVKTLRNNKSNMVETLEQYKFVYEVALEYLS
 .|||  | ||.|... . .. .   . |.  | |.        .. || .||  . .||. | |. ..||  |.|..
llvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiyealLkyfa
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 1394-1455 4.5e-09 30.5 In-house 1-62 (69) alignment 
Range on Protein: 1394-1455
Range on HMM: 1-62/69.0
VVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALE
||||  | ||.||| ||      |. . ..|.|  |. .|  .  ||   ..| |...   |
vvhcssGtGrtGtfiaimvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalve
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 1394-1455 8.5e-09 29.7 In-house 2-63 (69) alignment 
Range on Protein: 1394-1455
Range on HMM: 2-63/69.0
VVHCLNGGGRSGTFCAICSVCEMIQQQNIIDVFHIVKTLRNNKSNMVETLEQYKFVYEVALE
||||  | ||.||| ||      |. . ..|.|  |. .|  .  ||    .| |...   |
vvhcssgtgrtgtfiaimvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalve