Gene PTPRN in Homo sapiens

Synonym: IA-2, IA-2/PTP, IA2, ICA512, R-PTP-N, PTPRN

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRN
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP105_AA protein Get Run
HsapP105_AA_691-971 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
RESP18 RESP18 domain 60-155 1.7e-38 118.4 Pfam-A 1-100 (105) alignment 
Range on Protein: 60-155
Range on HMM: 1-100/105.0
GQCQVGVGQARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLTQYVISQEMERIPRLRPPEPRPRDRSGLAPKRP----GPAGELLLQDIPTGSAPAAQH
||.||||.|..|| ....|||||||.||.||...||.|.|||||.|..|.||||.||||.|| .||... ||.|     ....|.| .  |....|. . 
GqgqvgveqlwplqglatpvlqrLqvvlqqlvpkglfWkDDltqevmaqkmerisrlrPqePedrdgkaaaptrtaevlskqeeklrlltPaskspkvkv
Receptor_IA-2 Protein-tyrosine phosphatase receptor IA-2 469-558 1.2e-43 134.5 Pfam-A 2-91 (91) alignment 
Range on Protein: 469-558
Range on HMM: 2-91/91.0
EEYGYIVTDQKPLSLAAGVKLLEILAEHVHMSSGSFINISVVGPALTFRIRHNEQNLSLADVTQQAGLVKSELEAQTGLQILQTGVGQRE
||.||||||..|||| .|.||||||||.|...|.|||.|||.|||.||..|.||||.|.|||...|.  |..||..|||.|||.|||..|
eefGYivtdkdpLsleeGlkLleilaelvklasssFidisvlGPavtFkvraneqnvstadvakaaveekdkLeketglkilqsgvgeke
0050432 (Phosphotyrosine protein) phosphatases II 678-974 2.1e-91 301.8 In-house 14-303 (308) alignment 
Range on Protein: 678-974
Range on HMM: 14-303/308.0
WCEEPAQANMDISTGHMILAYMEDhLRNRDRLAKEWQALCAYQAePNTCATAQGEGNIKKNRHPDFLPYDHARIKLkvessPSRSDYINASPIIEHD-PR
..... ....   . . .| ..|. . .. .| .|...|....  .... .|. . |..|||..|.||||| |.||     .. ||||||| .  ..  .
frdtsilvsslklsvldllkllek.aldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgysskl

MPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDE---GASLYHVYEVNLVSEHIwCEDFLVRSFYLKNVQTQETRTLTQFHFL
  ..|||||||..|..|||.|||| ...|||||| |||.|...|..|||.|   |   |. . |.|.||.. ..|. || ..|.|....|.||.|.||..
prkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhyt

SWPAEGTPASTRPLLDFRRKVNKCYrgRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGvKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAI
.||  |.| |...|||| ..|.|..  ...||.||||.| |||||.|..|..|... |. ...|.  .. ..| |||| | ...|..|   |..| .. .
nWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

L
|
l
0039614 (Phosphotyrosine protein) phosphatases II 678-973 1.5e-83 276.0 In-house 3-292 (297) alignment 
Range on Protein: 678-973
Range on HMM: 3-292/297.0
WCEEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAEpntCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSP-SRSDYINASPIIEHDPR
....... ...|..... |... ... .. .| .|.. |. .. .   . .|. . |..|||..|.||||| |.|||.| .    ||||||| .  .| .
plrdallesipiplsvldlllllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydll

MPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVkQCDRYWPDEGAsLYHVYEVNLVSEHIwCEDFLVRSFYLKNvqTQETRTLTQFHFLSWP
 ...|||||||..|..|||.|||| |.|||||||.|||.|. .|..|||.||   |. . |.|....  .... || . ..|  ..|.||.|.|....||
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgwp

AEGTPASTRPLLDFRRKVNKCYRG--RSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGvKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAI
  |.| |.. ||.| ..|.....   ...|..||||.| |||||.|.....|... |. ...|.  .....| |||| | . .|..|   |..| .. .
dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPRN_pd Subfamily PTPRN 679-975 1.5e-176 580.3 In-house 1-297 (297) alignment 
Range on Protein: 679-975
Range on HMM: 1-297/297.0
CEEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMP
.|||...|.||||||..|.|.||||.|.|||.|||.|||||.|||.|...|. | |.||||. ..|||||.|.||| |.| ..|||||||.|..||||.|
seepvvsnldistGhvvlsyledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap

AYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAE
|||||||||..|.|||||||||.|..|||.||.| |.|||||.|||||||...||.|||.||||||||.|.|||||||||.||.||||.|||||||||.|
ayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpee

GTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAILK
|.|||...||.|||||||.||||||||.|||||||||||.|||||.||||..||||||||||||||.||||||||..||||||||||||||||||||
gvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnailk
0045450 (Phosphotyrosine protein) phosphatases II 684-968 2.3e-81 269.2 In-house 4-302 (307) alignment 
Range on Protein: 684-968
Range on HMM: 4-302/307.0
QANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAE-PNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSP-SRSDYINASPIIEHDP------
. .. |.. ...|......| .. .|.||.. |. .. . .... .|. . |..|||..|.||||| |.||.....  . ||||||| .. ...      
plslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldgy

-RMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGAS-LYHVYEVNLVSEHIwCEDFLVRSFYLKNV-QTQETRTLTQFHF
 .  ..|||||||..|..|||.|.|| |.|||||||.|||.| ..|..|||||| .  |. . |.|.||.. .... || . ...  .|.|.||.|.||.
dlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhy

LSWPAEGTPASTRPLLDFRRKVNKCYRG--RSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKE--IDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE
..||  |.| |. .|||| ..|.|...   ...|..||||.| |||||.|.....| .. |. .   .|.  .....|.|||| | . .|..|   |..|
tgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0051299 (Phosphotyrosine protein) phosphatases II 686-968 5.6e-90 297.0 In-house 2-284 (288) alignment 
Range on Protein: 686-968
Range on HMM: 2-284/288.0
NMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAEpNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIiEHDPRMPAYIATQG
...||. ... .... ....  .|..|...|.....  .|. .|. . |..|||..|.||||| |.||.|... . ||||||| | .  ..  ..|||||
dteisveellklvlkllangltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi.dgynlkrkfIatqg

PLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIwCEDFLVRSFYLKNV----QTQETRTLTQFHFLSWPAEGTP
||..|..|||.|||| ...||||||.|||.|...|..|||..|   |. . |.|.||.. ..|. || ....|.    ...|.|| |.||...||  |.|
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp

ASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGvKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE
 |...|||| |.|.|... ...|..||||.| |||||.|..|..|... |. ...|.  .....| ||||.| . .|..|   |..|
dspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0043336 (Phosphotyrosine protein) phosphatases II 689-967 4.2e-82 271.0 In-house 2-274 (278) alignment 
Range on Protein: 689-967
Range on HMM: 2-274/278.0
ISTGHMILAYMEDHLRNRDRLAKEWQALCAYQAepNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIiEHDPRMPAYIATQGPLS
||. ... |..| .| .. .| .|.. |. ..   .|. .|. . |..|||..|.||||| |.||.....   ||||||| . .  .. ...|||||||.
isvkdllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv.dgynvprkfiatqgPlp

HTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPdEGASLYHVYEVNLVSEHIwCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLL
.|..|||.|||| |.|.|||||.|||.|...|..||| .|   |. . |.|..|.  ..|. || . ..| .. |.|| |..|.|.||  |.| |. .||
etvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

DFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVkEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVA
|| ..|..... .. |..||||.| |||||.|.....|... |.  ..|.  .....| |||| | . .|..|   |..
dflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyeall
0040438 (Phosphotyrosine protein) phosphatases II 692-970 1.5e-84 279.3 In-house 3-276 (317) alignment 
Range on Protein: 692-970
Range on HMM: 3-276/317.0
GHMILAYMEDHLRNRDRLAKEWQALCAYQAEpnTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIiEHDPRMPAYIATQGPLSHTI
 ...||..  ....  .| .|.. |. .. .  |. .|. . |..|||.||.||||| |.||.....   ||||||| . .   . ...|||||||..|.
ldlllalldllksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv.dgpnlkrkfIatqgPlpntv

ADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIwCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFR
.|||.|||| |.|||||||.|.|.|...|..|||...   |. . |.|.||.  .... .| . ... ...|.||.|.||...||  |.| |...|||| 
edFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfl

RKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVkEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV
..|.........|..||||.| |||||.|.....|... |.  ..|.  .....| |||| | . .|..|  .|..| .
eavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleyl
0047943 (Phosphotyrosine protein) phosphatases II 697-968 4.5e-84 277.4 In-house 2-270 (273) alignment 
Range on Protein: 697-968
Range on HMM: 2-270/273.0
AYMEDHLRNRDRLAKEWQALCAYQAePNTCATAQGEGNIKKNRHPDFLPYDHARIKLkvesSPSRSDYINASPIiEHDPRMPAYIATQGPLSHTIADFWQ
... ..| ....|..|...|. ..  . |. .|. . |..|||..|.||||| |.||    ... ||||||| . .  .. ...|||||||..|..|||.
llllekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwr

MVWESGCTVIVMLTPLVEDGVKQCDRYWPDEG---ASLYHVYEVNLVSEHIwCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRK
|||| ...||||||.|||.| ..|..|||.||      |. . |.|.||.. ..|. || ..|.|..|.|.|| |.||...||  |.|.|. .||.| ..
mvweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefiel

VNKCYRG--RSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGvKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE
|.|...   .. |..||||.| |||||.|..|..|... |. ...|.  .. ..|.|||| | . .|..|   |..|
vrkalealpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_Ptp69D_pd Subfamily Ptp69D 697-969 1.1e-64 213.5 In-house 12-285 (307) alignment 
Range on Protein: 697-969
Range on HMM: 12-285/307.0
AYMEDHLRNRDRLAKEWQALCAYqAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMpAYIATQGPLSHTIADFWQ
|.   .      ||||.. | |    . .. ... . |  |||..|  ..|. |.|||.      ||||||| |. .. .   .|| |.|.  || |||.
alksrkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekk.kfiaaqdPveatigDfWR

MVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIwCEDFLVRSFYLKNVQ-----TQETRTLTQFHFLSWPAEGTPASTRPLLDFR
|..|   |.||||. | |   |.|..|||.|    |    |.||||.  ..|.  |.... ...      ...| ..|.|...|.    | ..| ||.. 
miaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevargllkli

RKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKgVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEE
..|.. |.    ||.|||| |.||.|... .|..|... .  ...|| .|  ..| ||. ||.| .|..|   |... 
eqvrelyklnrsPivvhCsaGvgrsgifvaldsllqqlka.edkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_PTPRB_pd Subfamily PTPRB 698-967 3.7e-70 231.3 In-house 16-282 (293) alignment 
Range on Protein: 698-967
Range on HMM: 16-282/293.0
YMEDHLRNRDRLAKEWQALCAYQAEpNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDpRMPAYIATQGPLSHTIADFWQM
... . ..  |...|.. | | . . .....|. . | .|||. . |||||.|.||.  .. | ||||||. | ..   .  .||||||| .|. |||.|
vkkmkadsdlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgyn.sprefiatqGPlpetvddfWrm

VWESGCTVIVMLTPLVEDGVKQCDRYWPDE-GASLYHVYEVNLVSEHIwCEDFLVRSFYLKNvqTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNK
|||. ...||||| ||| | ..|..|||..  . ||   .|.||.|.   ||. .|.. ...  ..|.|...|.||.|||  | | .|..|||| |.|..
vwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeee.ledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvre

CY--RGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKgVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVA
      .. ||.|||| | |||||.| .|..|... .    .||.... ..| .|  || ...|. |  ..| 
aiektaskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvl
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 698-969 1e-64 213.9 In-house 25-290 (319) alignment 
Range on Protein: 698-969
Range on HMM: 25-290/319.0
YMEDHLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDpRMPAYIATQGPLSHTIADFWQM
  .|   .. .|  |....|   ..  . . |  . |  |||  . |..|....||.       ||||||| .  .  |   |||.||||  |.||||.|
nksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyq.rkdkyiaaqGPldntladfWrm

VWESGCTVIVMLTplvedgVKQCDRYWPDEGASLYHVYEVNLVSEHIwCEDFLVRSFYLKN-VQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNK
.||. |. ||.||       ..| .||| ..   .  ..|.. | .  .... ||.. | .  . .. | .|||||| ||  | | .. .|. . .||..
iweyncstivllt......kdkcsqywplkivikeerfkvkvdsvee.taeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmrlvkkvrh

CYR--GRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKgVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEE
  .      .|.|||| |.||||.|| .|..|.|| .  | .|.  ... .|.||. ||..  |. |  .|. ||
ltskenhranivvhcsaGvGrtGvyivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 698-972 2.3e-62 205.9 In-house 13-285 (305) alignment 
Range on Protein: 698-972
Range on HMM: 13-285/305.0
YMEDHLRNRDRLAKEWQALCAYqaePNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIiEHDPRMPAYIATQGPLSHTIADFWQM
 .|..  . . | .....|.     ....   . | | .|||. .  ..|. ||.|. ..|   ||||||| . .   |  .||..|||| .|.||||..
ikearvysdkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyv.dgykrkkkyivaqgPlkntvadfWrl

VWESGCTVIVMLTPLVEDGVKQCDRYWPDEGAS--LYHVYEVNLVSEHIwCEDFLVRSFYLKN-VQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKV
..|   ..||||| |||.| ..| .|||.. .    .  ..|.| ||.   .|.. | . . .  . .|.||..|... .|| .| | ..  ||.. ..|
iveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksekt.asdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslikrv

NKCYR-GRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKgVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNA
.| .. ..  |..||||.| ||||..| .|. |.|. |  ...|..  | ..| .|...| ..||. |   |..|....
qkdqkkdkgvpllVhCsagvgRtGvfiavdialerlkk.EevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
0036941 (Phosphotyrosine protein) phosphatases II 699-969 6.5e-82 270.5 In-house 5-276 (297) alignment 
Range on Protein: 699-969
Range on HMM: 5-276/297.0
MEDHLRNRDRLAKEWQALCAYQAePNTCATAQGEGNIKKNRHPDFLPYDHARIKLkvesSPSRSDYINASPIiEHDPRMPAYIATQGPLSHTIADFWQMV
. ..| .. .| ||.. |. ... . .. .|. ..|..|||..|.||||| |.||    ... ||||||| . .   .  ..|||||||..|..|||.||
llekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmv

WESGCTVIVMLTPLVEDGVKQCDRYWPDE--GASLYHVYEVNLVSEHIW-CEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVN
|| ..|||||||.|||.| ..|..|||.|  .   |. . |.|.|.... ..|. .| . .......|.||.|.||...||  |.| |...|||| ..|.
weqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvr

KCYRG--RSCPIIVHCSDGAGRTGTYILIDMVLNRMAK--GVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEE
|...   .. |..||||.| ||.||.|..|..|... .    ...||  .. ..|.|||| | . .|..|   |..| 
kvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 699-972 2e-68 225.8 In-house 15-285 (319) alignment 
Range on Protein: 699-972
Range on HMM: 15-285/319.0
MEDHLRNRDRLAKEWQALCayQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRmPAYIATQGPLSHTIADFWQMV
.. .      |.||.. |   .|...|  .|. | | ||||... |.||..|..|.       ||||||| |  .. |  ..||||.||..|| |||.||
kalastgetllekefkllk..eavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqer.ekfiatqaPlentiedfWrmv

WESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHiWCEDFLVRSFYLKNVQTQ-ETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKC
|| .. ..|||| ||| .  .. .|||.|    |  . |.| .|.   ||. .| . |.. ... |||....|....|| .. | ... |||. ....| 
WeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeee.eledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirks

YRG-RSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGvKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNA
 ..  | ||.||||.|.|||||.| .|..|.|. .    .|.  |  ..| ||. .|. ..|..|   |. | |.|
rektqsgPivvhCsaGvGRtGtfivldamlervkee.gvlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 700-972 1.6e-57 189.6 In-house 13-285 (290) alignment 
Range on Protein: 700-972
Range on HMM: 13-285/290.0
EDHLRNRDRLAKEWQALCAyQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSP--SRSDYINASPIIEHDPRmPAYIATQGPLSHTIADFWQM
..| .....  .....| .  ....|  .. .. | ..||  ....||  || |.  |.      .||||. | ..  .  .|||||||.|.|..|||..
nghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgykek.kqyiatqgpvsntlvdFWkl

VWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCeDFLVRSFYLKNVQT-QETRTLTQFHFLSWPAEG-TPASTRPLLDFRRKVN
.|.  .|.|||||  .|.| ..|  ||||.... |  ....|..|..   ..  | . .|| .. ......||... .|. .|  .. .  || ... ..
iwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

KCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMaKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNA
. ..    .|.|||||. ||..... ... .|.. |    ||. . |.. | |.||.| ...|...  . | . .. 
tqrkrgntsivvHCSdtvgrsavfcaaattinkc.ktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 700-972 2.6e-54 179.1 In-house 13-280 (287) alignment 
Range on Protein: 700-972
Range on HMM: 13-280/287.0
EDHLRNRDRLAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKvessPSRSDYINASPIiEHDPRMPAYIATQGPLSHTIADFWQMVW
..| ....   . .. |   . ...    .  . | .|||  ..|..|  |. ||      . |||||. | .      |.|....|...|. .||....
kghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfi.dgykekkafiiaesPmfntarnfWklid

ESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHiWCEDFLVRSFYLKNVQ-TQETRTLTQFHFLSWPAEG-TPASTRPLLDFRRKVNKC
.   |.||||. . |.  ..| .|||.| . ..  |...|..|.   .....| . .|| . ........|... .|. .|  .     || . ... . 
drnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq

YRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKgVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNA
..    .|.|||||. ||..... ... .|.  .    ||.   |.. | |.|| |.  .|..|   .| | ...
rkrgntsivvhCsdtvGrsamfcaaattinkckt.eGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_ptpA1_pd Subfamily ptpA1 700-939 1.8e-37 124.1 In-house 14-266 (418) alignment 
Range on Protein: 700-939
Range on HMM: 14-266/418.0
EDHLRNRDRLAKEWQALcAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRmpAYIATQGPLSHTIADFWQMVW
..|..   .. .|.. |      |.  .  . . |  |||. . || .|.|..||       ||||||  |    |.   .|.|||||  ||||||.|||
knhikcihkikeefrll.eesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypk..qfictqgplpntiadfwrmvw

ESGCTVIVMLTPLVEDGVKQCDRYWPDE-----------GASLYHVYEVNLVsEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLL
|  | .||||.   |.   .||||||..           |  ..  | |.|| | |   .  . .  ..     ||| .||...  ||    |  |.|. 
enrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelv.eviqdpereiitrnirltfegetrditqyqyegwpdhnipdhtqpfr

DFRRKV----NK--CYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIA
.. . .    |.      |  ||||||| | |||||.    ...... . .|..| .
qllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldhyfkqldat
subfamily_PTPN23_pd Subfamily PTPN23 702-974 3e-60 198.5 In-house 10-284 (288) alignment 
Range on Protein: 702-974
Range on HMM: 10-284/288.0
HLRNRDRLAKEWQALCAYQA-EPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKvessPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWE
 | ..  | |... |  .|. | .  ..|  . . .|||. | |||||.|.||.     |. |||||| . .  |  | .||||.||  |..|||.||.|
mldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmvye

SGCTVIVMLTPLVEDGVKQCDRYWPDEG--ASLYHVYEVNLVSEHiWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCY
    |||||.   | | ...||||| .   .  .  ..| | |..   | .  | . |.  .........  .. |||  | |||   ||.|  .|...|
qkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvr.etethvervlkletldadavksvshlqltsWpelGvPasPetllqfldevesay

R----GRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAIL
.        |..|||| | ||||.. |.  ... . ||   .||   ....| ||   |. |.|..|.. || |... .|
eavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 702-967 4.7e-51 168.3 In-house 5-274 (287) alignment 
Range on Protein: 702-967
Range on HMM: 5-274/287.0
HLRNRDRLAKEWQALCAY-QAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLkVESSPSRSDYINASPIIEHDpRMPAYIATQGPLSHTIADFWQMVWE
..| .| . || .||.   .. . |  .|.   ..||||. | ||.|..|. | .. .   ||||||  .  .  .  |.||.|||.. |. |||..|.|
errvkddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvll.saegelGsdyinanyvasyt.ddeafiaaqgPiaatvrdfwravle

SGCTVIVMLTPLVEDGVKQCDRYWPDEGAS-LYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPAS----TRPLLDFRRKVN
   ......|  ||.. ..| .|||.     .   | | |..  |   .. ||.. | ...|.|.| . |...||||... . .     |  || .....
trsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhie

KCYRGR-SCPIIVHCSDGAGRTGTYILIdMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVA
    .    |..||.. |.||.|... . .|| .. . . ..|.||.. ..| .| .||..  |. .   |..
lardasevGPlvvhddvGiGrsGillat.lvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 703-967 4e-73 241.0 In-house 17-276 (288) alignment 
Range on Protein: 703-967
Range on HMM: 17-276/288.0
LRNRDRLAKEWQALCAYQAEPNTCATAQGEgNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASpIIEHDPRMPAYIATQGPLSHTIADFWQMVWESG
 |||. . .|...| | . . ...|. . . | ||||... ||||. |.|||     . .||||||  |. . .. .|||||||| .|. |||..|.|  
arnrtgfseeynsLaalektksvtagrlav.nakknRyrnilpyDekrvklkkleeeagaDYinas.yidgekkkkkyiatqgPladtvndfWelvyenk

CTVIVMLTPLVEDGVKQCDRYWPDEGA-SLYHVYEVNLVSEHiWCEDFLVRSFYLKnvQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGR
 . ||||| |||.| ..|..||||..   .|   .| ||...   |||..|.. |.  .... ...||...|.|| .| |.|..|||...|.|.      
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlvesk.eledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad

SCPIIVHCSDGAGRTGTYILIDMVLNRMAKgVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVA
. |||||||.| |||||.| .|...... .  . ||.|.|....| ||. ||  . |.||   ...
tgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPRG_pd Subfamily PTPRG 703-971 7.4e-67 220.8 In-house 15-288 (563) alignment 
Range on Protein: 703-971
Range on HMM: 15-288/563.0
LRNRDRLAKEWQALCAYQAE-PNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSR-SDYINASPIIEHDpRMPAYIATQGPLSHTIADFWQMVWE
  .  ....|..||    ..   .. ..| . | .|||. . ..||..|.||.  .   .  |||||. |  .  .  |.||||||| .|. |||.|.||
adgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiWe

SGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWC----EDFLVRSFYLKNVQT-QETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVN
   ..|||.| |||.| ..||.||| ...  | . .|.|..|.. .    . . .. . ||. .  .. .. .|.|. .||  |.| .. | | | .| .
qnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkkss

KCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGvKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVN
.  .    ||.|||| |.||||||| .| .|... .  . ...  .| |.| ||. || ...|. |   |. | ..
aankaeaGPivvHcsaGvgrtGtyivldtllkqiqqe.navnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 703-974 7.8e-67 220.3 In-house 10-280 (281) alignment 
Range on Protein: 703-974
Range on HMM: 10-280/281.0
LRNR-DRLAKEWQALCAYQAEpNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDpRMPAYIATQGPLSHTIADFWQMVWES
 .|    ...|...| | . . ||   .. . |..|||. .   ||..|.|.. ... . .|||||. .   .    .|||||||. .....||||||| 
sqndnaGfieeyeklaaigvd.ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgyk.gekeyiatqgPvPaslvafWqmvweq

GCTVIVMLTPLVEDGVKQCDRYWPDEGA-SLYHVYEVNLVSEHIwCEDFLVRSFYLkNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRG
  ..|||.|  .| |  .| |||||. .   |  . |. ..|.   . .. | | | . .. |||...|.....||  | ||.|. ||.||..|.|. . 
kvsaivmvtreieagklkChrYWPddnselkygdvtvkstaeee.katyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlkltek

RS-CPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAIL
.. .|...||| | ||||||| .| .......  .|.|. |.....| .|  .|..  |.||   || . ..  |
ktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 703-970 6.7e-54 178.2 In-house 19-288 (325) alignment 
Range on Protein: 703-970
Range on HMM: 19-288/325.0
LRNRDRLAKEWQALCAYQaePNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASpIIEHDPRMPAYIATQGPLSHTIADFWQMV--WE
 ...| .|.|.. | . .  . .  .|    |..||| .. ...|..|. |.     . |||||||  .. | .   ..|.| ||..|| |.|..|  |.
aqdqdgfahefgllpsdd..giakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinas.ylrddkkkdvflaaqaPltatindlWrlvldWr

sgCTVIVMLTPLvEDGVKQCDRYWPDE-GAS-LYHVYEVNLVSEHIWcEDFLVRSFYLKNVQTQETRTLTQFHFLSWP---AEGTPASTRPLLDFRRKVN
  |.|.|.|  | . | ..|  |||.| | |  .   ||.|..      |.. | . .|.|.  |||.. ||.. ||.    .  ||.  ..|.   .|.
..csvvvvlnel.dlgkdrcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavs

KCYRG---RSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVkEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV
.. .     | ||.||||.| ||||..| .  .|... .   ..||   ....| .|| .|.. ||. .  .|..| .
ervtantkastpilvhcsaGvGrtGvfislysalakviees.rvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 704-971 5e-74 244.2 In-house 24-291 (298) alignment 
Range on Protein: 704-971
Range on HMM: 24-291/298.0
RNRDRLAKEWQALCAYQA--EPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMpAYIATQGPLSHTIADFWQMVWES
 .  ..|.|.| | . .   | ..   |. . | ||||..| ...|..|. |. |..   ||||||| .  .. |  |.||||.|| .|..|||.||.| 
kkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvtee

GCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCeDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKcYRGR
  ..|||||.|.| .  .. .||||||.  |   .|.| |..    |. || . ... .....|.. |.|| ||| .|.|. .. .||..|||.. .. .
digtiVmltnleeldktkyhkywPdegketygeitvsllskeefa.dlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqqq

SC--PIIVHCSDGAGRTGTYILIDMVLNRMaKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVN
.   |.||.||.| ||.||.| || ||.|. |  . .|.  ... .| .|||.|....|. |  .|| | ..
agnkpvivqCsaGvgRsGtfiaidsvlerv.kkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_PTPN9_pd Subfamily PTPN9 704-968 2.3e-61 202.5 In-house 13-288 (297) alignment 
Range on Protein: 704-968
Range on HMM: 13-288/297.0
RNRDRLAKEWQALCAYQAEpNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASpIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGC
...  | ||.... . ..|  |  ...  .|..|||. | | ||..|..|. ..  . ||||||.  ..   .  |.||||||| .|. |||.||||. .
kgkrGlskeyaeirnepve.Gtflasklranleknrytdvlcydetrvvlakvdedeasdyinan.fvdGykqkkafiatqGplkktvsdfWrmvWeqev

TVIVMLTPLVEDGVKQCDRYWPDE--GASLYHVYEVNLVSEHiWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKC----
 |||| | .|| |  .| .|||.|   .. .  ..|. |. .   ||. ||.. .|||.|.|.|..| | |||||  |.| |.  |||...|| .     
lvivmttrvvergrlkcgqyWpleeessaefgdlsvsnveve.eeedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekqala

---------YRGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKgVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE
         .. .  ||.|||| | |||||.| .|. |.|. . |  .|.  |....| ||   ..  .|.||   || |
vkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrlee.vgtvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 704-785 7.9e-07 23.2 In-house 20-95 (95) alignment 
Range on Protein: 704-785
Range on HMM: 20-95/95.0
RNRDRLAKEWQALCAYQAEPNTCAtaQGEGNIKKNRHPDFLPYDHARIKLKVEsspSRSDYINASpIIEHDPRMPAYIATQG
   . . .|....      | |.     | || |||  . .||| .|. |        ||||||  ...   |  .|||.||
nsdqefdnefksismtsgapytvg..sseanipknrflnifpydatrvvlttk...rdsdyinac.fvdgyarkncyiaaqg
subfamily_PTPRD_pd Subfamily PTPRD 705-972 2.4e-88 292.2 In-house 21-283 (564) alignment 
Range on Protein: 705-972
Range on HMM: 21-283/564.0
NRDRLAKEWQALCAYqaEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDpRMPAYIATQGPLSHTIADFWQMVWESGCT
.  .. .|.. .     .  |. .|. . | .|||  . ..||| |..|.     . ||||||| |  .. .. |||||||||..||.|||.||||  ..
sdlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweqnss

VIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIwCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCP
.||||| |.| | ..|..|||..|   |  ..|.|..|.   .|. .|.| ||. ...|.|. .|||| ||| .| | |...|||..|||... .  . |
tiVmltkleEkgkvkchkYWPekgtetygeltVtleeeee.ladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepdagP

IIVHCSDGAGRTGTYILIDMVLNRMAKgVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNA
|.|||| | |||||.| ||..|.|. .  | .||  .....| ||. .| ...|. |  .|..| ...
ivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 706-970 3.3e-48 159.0 In-house 19-236 (392) alignment 
Range on Protein: 706-970
Range on HMM: 19-236/392.0
RDRLAKEWQALCAYQAEPNTCatAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRmPAYIATQGPLSHTIADFWQMVWESGCTV
   ...|.. |   .. |.|.  || | |.||||. . |||| ||.||.|    . |||.||| |   |    ||||.||| . .. |||.||..   | 
salffeefhdlpgpdiypqtv..aqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdne.kayiasqgpnaaslddfwrmvfqenvtt

IVMLTPLVEDGvkqcdrywpdegaslyhvyevnlvsehiwcedflvrsfylknvQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPI
|.|.| | |                                             . ...|| .||||  || .. |  |  || | ..|.  .   . |.
iamvtklkegd...........................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpl

IVHCSDGAGRTGTYILIDMVLNRmAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV
|.||| | ||||  | || |. . || .. .|.   .  .| .|| .|..|.|. |   || |..
iihcsagvgrtgvvisidsvvah.akktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 706-964 8.3e-37 121.5 In-house 14-287 (301) alignment 
Range on Protein: 706-964
Range on HMM: 14-287/301.0
RDRLAKEWQALcaYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESS--PSRSDYINASPIiEHDPRMPAYIATQGPLSHTIADFWQMVWESGC
 .........|  ...|...|     | | . ||. .  .||. || || ...   .. .||||| | .   .  ..||.|||. .|..|||...|.   
snkfeeqykel..kegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyi.dgysekkkfiaaqgpmkktlvdfWrliwqekp

TVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEV-NLVSEHIWCEDFLVRSFYLK---------------NVQTQETRTLTQFHFLSWPAEGTPASTR-P
. |||.| | |.  ..| .|||.  |. ...... ......    ||..|.. .|                 .........|..  .|| .|     |  
vsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvreprtv

LLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRmAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALT
|      . .  .    |..|||||. .|.|.|. ... |   .|    .|.    . || ..|| |   .|. .   
LqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQ.ckaegVVdvfqvtkavrrskpgaVtTLeqytsiyd
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 707-949 4.4e-25 82.9 In-house 27-269 (310) alignment 
Range on Protein: 707-949
Range on HMM: 27-269/310.0
DRLAKEWQALCAYQAEPNTCATAqgEGNIKKNRHPDFLPYDHARIKLKVESSpSRSDYINASPIIEHDPRmPAYIATQGPLSHTIADFWQMVWESGCTVI
. |.|... | | |    |  .   . ...|||. | .  | .|.|||.. |    ||| |  .     |  ..| .|||| ||| |||.|...  .  |
eglvkqyrkldakqdssltyeay..kkymhknrysdvvcldtsrvklkidks.ryedyihanyvktnylr.stficsqgplqhtiidfwrmifqeraesi

VMLTPLVEDGVKQCDRYWPDEGAS-LYHVYEVNLVSEHiwCEDF----LVRSFYLKNVQTQETRT------LTQFHFLSWPAEGTPASTRPLLDFRrKVN
..|   .|.|  .|  |||  | .  | .  |  .||    |.|    |  .|   ||  .|  .      ..  ..  ||  | |      .  |  . 
lllckvgeegrpkcvgywpslgvtetygcirvtnlses..seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqr.lla

KCyrgRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKeIDIAATLEHVRDQR
.    |  | .|||| | .|... . ... .... .| | .|.     ... .|
qv...rhgpcvvhcsagkdrlyvvvalklkidkldrglk.vdaeevktellksr
subfamily_PTPN6_pd Subfamily PTPN6 708-969 1.4e-70 232.7 In-house 27-296 (306) alignment 
Range on Protein: 708-969
Range on HMM: 27-296/306.0
RLAKEWQALCAYQAE-PNTCATAQGEGNIKKNRHPDFLPYDHARIKLKvESSPSRSDYINASPII-EHDPRMPAYIATQGPLSHTIADFWQMVWESGCTV
 . .|...|   .|.   .   ..   | .|||.   ||.||.|..|| |.| . ||||||. |  |      .|||||| |..|..|||.|||.  ..|
gfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrmvwqensrv

IVMLTPLVEDGVKQCDRYWPDEGASL-YHVYEVNLVSEhIWCEDFLVRSFYLK-NVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRS-
|||.|  || | ..| |||||| ..  | ...|. |||    .|. .|.. .. . . .|.|.. |.|| ||| .|.|...  .||| ..||. ..  . 
ivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvnrkqeelee

---CPIIVHCSDGAGRTGTYILIDMVLNRMAK-GV-KEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEE
    ||.||||.| |||||.|.||..|. . | |.  .|||  . . ||.|| |||. ..|. |  .|... 
aeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
subfamily_PTPRA_pd Subfamily PTPRA 708-968 1.4e-69 229.5 In-house 33-293 (330) alignment 
Range on Protein: 708-968
Range on HMM: 33-293/330.0
RLAKEWQALCAYQAEpNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIiEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIV
.. .|..|| | . . .|. .|. | | .||| .. ||||..|. | | .    ||||||| | .   .   .||.|||...|. |||.|.||   . ||
lfreefnalPagpiq.atlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfi.dGykekdkfiaaqGPkeetvedfwrmiweqksativ

MLTPLVEDGVKQCDRYWPDEGASLYHVYEVNlVSEHIWCEDFLVRSFYLK----NVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSC
||| | |   ..| .||||||.  |    |. | ..  ..|. || | ..    . . ...| ..|||| |||  | |. .. .|.. .||.|. .  . 
mltelkerkeekcaqywPdeGlvtyGnirve.vedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsag

PIIVHCSDGAGRTGTYILIDMVLNRMaKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE
||.|||| |.|||||.| .| ||.|. |  . .|.  .....| ||| .|... |.||   .. |
pivvhcsaGvGrtGtfivldavlerv.kaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
subfamily_PTPN13_pd Subfamily PTPN13 708-968 4.6e-62 204.8 In-house 12-267 (273) alignment 
Range on Protein: 708-968
Range on HMM: 12-267/273.0
RLAKEWQALCAYQAEpNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSpsrsdYINASPI-IEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVI
  |.|.. |   ..  .|| ... . | .|||. . ||||..|.||. |..     ||||| | .. .     |||.|||| .|..||||||||  ..||
qPaeefkelrelkpl.dtcevgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkaevi

VMLTPLVEDGVKQCDRYWPDEGASLYHVYE---VNLVSeHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRgRSC
.|.|  .|.|  .|.||||..  .   |..   |.|.      ..| ||.. .|.....|.| .....| .||  |.|.|. .|| | ..|..  .  . 
amvtlekekgkvkchrywPesknkklkvsnrlevellk.vqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.dag

PIIVHCSDGAGRTGTYILIDMVLNRMAKGVkEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE
||.|||| | ||.||.| ||.||. ...   |.|.  .....|.|| |.|..|||. |   |. |
PivvhcsaGiGrsGtlitidvvlglierdk.efdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 708-969 1.4e-20 68.2 In-house 20-275 (312) alignment 
Range on Protein: 708-969
Range on HMM: 20-275/312.0
RLAKEWQALCAYQAEPNTCATAQgegNIKKNRHPDFLPYDHARIKLKVEsspsRSDYINASPIiEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIV
.|.||..|.    .. .  |  .       ||.|.   .|  |. |  .       || |  .     .   ...|||||  |.. |||..   |.| |.
qltkeykavgnivsdsectaflk...fkdlnrypniqcwdrgrftlagd....enfyihanfv.kictkperfvctqgplentcthfwqlalslgstsii

MLTPLVEDGVKQCDRYWPDEGASL----YHVYEVNLVSEHIW--CEDFLVRSfYLKNV--QTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKcyr
.|. .|||| ..| .|  |  . .    . ||        |     | .     || |   | .   | .. . |||  | | |    | .   |.|   
llcgfvedgsekcakyisdivgfvdledhrvyteycteieiggkskdkithr.vlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk...

gRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEiDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEE
    |.| ||| | ||||| .||. ..  . .  |. ..  ..  .| .|   ||   |. .|| .| | 
.dkkpviahcsagvgrtgtlaliesmiaalrhprkq.nvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 708-962 8.5e-16 52.2 In-house 27-277 (302) alignment 
Range on Protein: 708-962
Range on HMM: 27-277/302.0
RLAKEWQALCAYQAEPNTCATAQgeGNIKKNRHPDFLPYDHARIKLKVEsspsRSDYINASPIIEHDPRmPAYIATQGPLSHT---IADFWQMVWESGCT
.. ||.... . ... . | . .   |.|||...|.  .|. ..||. |      .|.||| .   . . .  | .| | . .   ...||.||..  ..
evkkefkkidtmkvdlekCkafk..knlkknqsedvpildsnlvkleae....pdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekiv

VIVMLTplVEDGV-KQCDRYWPDEGASlYHVYE-VNLVSEHIWCEDFLVRSFYLKNVQTQ--ETRTLTQFHFLSWPAEGTPASTRPLLDFRRKV-NKCYR
 .|.|    |. . |  . ..| .  . |. |. . .    .   .  .  ...  .     ..   .  ..  |...  | .   |     || .|   
svvilv..geeelkktlselfpkksgd.ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkik

GRScPIIVHCSDGAGRTGTYILIDMVLNRMAKGvKEIDIAATLEHVRDQRPGLVRSKDQFEFA
. . ....    |||| |. .   ...... || ||  |. ... .| |||  | | .|. . 
ade.ntvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvsl
0046845 (Phosphotyrosine protein) phosphatases II 709-973 1.5e-84 279.0 In-house 2-277 (284) alignment 
Range on Protein: 709-973
Range on HMM: 2-277/284.0
LAKEWQALCAYQAEPN-TCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSP-SRSDYINASPIIEHD----PRMPAYIATQGPLSHTIADFWQMVWESG
| .|...|. ..  .  .. .|. . |..|||..|.||||| |.|||....  . ||||||| .  .|     . ...|||||||..|..|||.|||| .
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CTVIVMLTPLVEDGVKQCDRYWPDEG-ASLYHVYEVNLVSEHIwCEDFLVRSFYLKNVQ-TQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYR-
..||||||.|||.|...|..|||.||    |. . |.|.||.. ..|. || ..|.|.. |.|.||.|.||..|||  |.|.|...||.| |.|..... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-GRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVK--EIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAI
 ....||.||||.| |||||.|..|..|... |.    ..|.  .. ..|.|||| | . .|..|   |..| .. .
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 709-972 1.5e-74 246.0 In-house 22-282 (318) alignment 
Range on Protein: 709-972
Range on HMM: 22-282/318.0
LAKEWQALCAYQAEPnTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASpIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVM
| .|...|   .... |   .  . | .|||. . |.|||.|.||.  ..   ||||||.  |.   |  ||||.|.||..|| |||.|||| ...||||
lseeyerlsrseetv.tslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinan.yidGyrrkkayiaaqaPlpetieDfWrmvWeqnsavivm

LTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSeHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCY-RGRSCPIIV
|| ..| | ....||||..|.  |    |.| . .. ..|...|.| ... ...|.|.  |.|. ||| ||.|.|.  |||. |.|.|   .    ||.|
ltqeeergkakvhryWPskgsrsygklvvelke.evelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagpivv

HCSDGAGRTGTYILIDMVLNRMAKgVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNA
||| | ||||..| .|..|.|...  . .|.  | ...|.||. .|. .||.||  ... | ...
hCsaGvGrtGvfiavdillerika.ealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 709-970 7.2e-60 197.5 In-house 20-276 (515) alignment 
Range on Protein: 709-970
Range on HMM: 20-276/515.0
LAKEWQALCAYQAEPNTCatAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRmPAYIATQGPLSHTIADFWQMVWESGCTVIVM
...|.. |   .  |.|   || | | ||||. . |||| .|.||.|      |||.||| |   |    ||||.|||.  .. |||..|..   | |.|
fseefhdlpgpniypqtv..aqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdnd.kayiasqgPnkasvddfWrlvlqenvttiam

LTPLVEDGVKQCDRYWPD-EGASL-YHVYEVNLVSEHIwCEDFLVRSfyLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPII
.| | |.   .| .||||  | |. .  ..|.||| .  | . . |   |. .. ...||.|||||  || .|.|  |. || . ..|       . |.|
vtklkegdkikcgkyWPdkpgdsvkfGsikvelvslea.ctggikrk..ltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpli

VHCSDGAGRTGTYILIDMVLNRMAKGvKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV
.||| |.|||| .| || |. ..... . .|.  ... .|..|| ||. ..|. |   || |..
ihcsaGvGrtGvvisidsvvahaktt.rmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 709-970 9.1e-57 187.3 In-house 21-277 (315) alignment 
Range on Protein: 709-970
Range on HMM: 21-277/315.0
LAKEWQALCAYQAEPNTCatAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRmPAYIATQGPLSHTIADFWQMVWESGCTVIVM
...|.. |   .. ...   |. . | ||||. . ||.|.||.||.|      ||||||| |   |    ||||.||||  .. |||.||...  | |||
fseefhdlpdPdiyrqrv..aretinfkknryknilPldsarvkleviddsPdsdyinasyiksvddd.kayiasqgPlkasvddfwrmvlqekvttivm

LTPLVEDGVKQCDRYWPDEGAS--LYHVYEVNLVSEHiWCEDFLVRSFYLKNvqTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPII
.| . |.   .| .||||. |    .  ..|.|.| .  . |  .| . ...  ..|.||.|||.|  || .|..  |  || . ..|    . .  ...
vtkkqegdkikcrqywPdrkadsvefGsikvellsle.adtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsll

VHCSDGAGRTGTYILIDMVLNRMAKGvKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV
|||| |.||||  | || |....... . .|.  ... .|..|| ||...... |   || |..
vhcsaGvGrtGvvisidevvaqikrt.rsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_PTPN14_pd Subfamily PTPN14 709-967 4.3e-54 178.5 In-house 25-293 (300) alignment 
Range on Protein: 709-967
Range on HMM: 25-293/300.0
LAKEWQALCAYQAePNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPsRSDYINASPIIE-HDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIV
. .|.. .   ..   .. ||. . | .|||..|.|||...|..|.      ...||||| |      .   ||..|||| .|. ||||||||.| ..||
vfteyeripkkre.dallstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvqliv

MLTPLVEDGVKQCDRYWPDEGASLYHV-YEVNLVSEHIW--CEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNK-------C
|||   ||| ... .|.|... .  .| ..   |...     . .  ... || . ..| ||.  . .  || .| |   .. |.. ..|.         
mlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrktnse

Y--RGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGvKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVA
   . .. |..||||.|.||||  || |.... . .. .||||  .|...| ||  ||..  |..|  ... 
veskeskPPvlvhCsaGvGrtGvlilsdlliatlehn.eeidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 709-975 3.1e-37 123.0 In-house 8-264 (267) alignment 
Range on Protein: 709-975
Range on HMM: 8-264/267.0
LAKEWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVesspSRSDYINASpIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVM
. ||.. .     . .|...  .| | ..||  | ||||..|. |.     .  .|||||  .|   .  |.|.||.||. ||.||.... . ...|||.
iekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrt....keeeyinas.yvegyktknafivtqdplkntitdfltvihdqkvpvivl

LTPLVEDGVKQcdrYWPDE--GASLYHVYEVNLVSEHiWCEDFLVRSFYLKnVQTQETRTLTQFHFLSWPAEGTP-ASTRPLLDFRRKvNKCYRGrSCPI
||.  .| ...   .|| .   |  |.   |.   |.   .|. . .. || .. . .. .| ...  |  .       .||.    | |.   | . |.
ltkvftdnirl...fwPPkmgqakkyqdltvehslek.eendyqiitlelk.fknesahnvtlyyykkwnintnnkpylkplfgilak.nqleng.nrPl

IVHCSDGAGRTGTYILIDMVLNRMaKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAILK
.|.|||| ||.||.. ||  |.|. |     ||   | ..|.||.||| .|... .    .||  .  ||
vvacsdGvGrsGtflvidsqlera.ktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrlk
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 709-959 5.5e-33 109.3 In-house 18-266 (307) alignment 
Range on Protein: 709-959
Range on HMM: 18-266/307.0
LAKEWQALCayQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSpsRSDYINASPI-IEHDPRmpAYIATQGPLSHTIADFWQMVWESGCTVIV
|  |.. |.  . .|.. ..   . | .|||. |    |..|| .|..     |||| |  . |  .|.   .|..||||  |. .|| |. .     ..
lvdefrvla..kktpegvtveafsantdknryqdvkcqdkgrivvkfdgl..asdyihanylgiaikpk..kficaqgplentqysfwamaiqekvesvi

MLTPLVEDGVKQCDRYWPD-EGASLYHVYE------VNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVnkcyRG
||  ..| .  .|..|||  ||  | .. .       || ....  .. |.    || . .|..||.... .  || .|.|      ...   |    |.
mlckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleav....ry

RSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQF
   |..|||| | ||.|| . | .| ..| .|.   |.   .| .|.||.  .... |.
dtnpvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqy
DSPc_SM00195 711-970 7.8e-80 263.3 In-house 4-262 (263) alignment 
Range on Protein: 711-970
Range on HMM: 4-262/263.0
KEWQALCAYQAEPnTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASpIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLT
.| . | ... .  .. .|. . | .|||. ..||||| |.||| | ... ||||||. .|. . .  .||||||||..|..|||.|||| ....|||||
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAn.yikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

PLVEDGVKQCDRYWPDE--GASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVH
  .|.| ..||||||.|  | . .. ..|.||....  ... .| . |.. ...|||..||... .|| .|.| ||...|.. |.|.|...  | ||.||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSDGAGRTGTYILIDMVLNRMAKGVKeIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV
||.| |||||...||..|...... | .|| ......|.||||.|....|. |. .|..| .
CsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 711-970 7.8e-80 263.3 In-house 4-262 (263) alignment 
Range on Protein: 711-970
Range on HMM: 4-262/263.0
KEWQALCAYQAEPnTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASpIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLT
.| . | ... .  .. .|. . | .|||. ..||||| |.||| | ... ||||||. .|. . .  .||||||||..|..|||.|||| ....|||||
eefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAn.yikgankkkkyIatQgPlpstvedFWrmvweekvkiivmlt

PLVEDGVKQCDRYWPDE--GASLYHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVH
  .|.| ..||||||.|  | . .. ..|.||....  ... .| . |.. ...|||..||... .|| .|.| ||...|.. |.|.|...  | ||.||
eeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivVh

CSDGAGRTGTYILIDMVLNRMAKGVKeIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV
||.| |||||...||..|...... | .|| ......|.||||.|....|. |. .|..| .
CsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_PTPN12_pd Subfamily PTPN12 711-977 2.9e-71 234.7 In-house 12-284 (290) alignment 
Range on Protein: 711-977
Range on HMM: 12-284/290.0
KEWQALCA----YQAEP-NTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASpIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTV
||.|.| .    |.||   . .... | |.||||. | ||||..|..|. ...   ||||||. .|..     .|||.||||..|. |||.|.||   ..
kefqklkklsekykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinan.fikgvegkleyiaaqgPLpktlddfWrmiweknvei

IVMLTPLVEDGVKQCDRYWPDEG-ASL-YHVYEVNLVSEHIWCEDFLVRSFYLKNVqtQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSC
.||.  .|| | |.|.||||.||  .| .  .||.| .|.   .|||.|.. ...   .|.|...|||. .||  |.|.|. .||.. ..|..  .  . 
vvmaCrevelgkkkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqeseda

PIIVHCSDGAGRTGTYILIDMVLNRMAKGVK--EIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAILKAL
|..|||| | ||||| | ||.| . . ..    |.|.   . ..| ||. ||..|.|.|.   |||| |.. |...
PlvvhCsaGvGrtGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleii
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 712-969 9.9e-63 207.3 In-house 3-254 (284) alignment 
Range on Protein: 712-969
Range on HMM: 3-254/284.0
EWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDpRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTp
|....|   ..  . . |  . |  |||  . |..|....||.       ||||||| |  .  |   ||||||||  |.||||.|.||. |. ||.|| 
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyq.rkdkyiatqGPldntladfWrmiweyncstivllt.

lvedgVKQCDRYWPDEGASLYHVYEVNLVSEHIwCEDFLVRSFYLKN-VQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYR--GRSCPIIVH
      ..| .||| ..   .. ..|.. | .  .|.. ||.. | .  . .. |...||||| ||  | | .. .|. . .||..  .      .|.||
.....kdkcsqywplkivikeerfkvkvdsvee.seeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvh

CSDGAGRTGTYILIDMVLNRMAKgVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEE
|| |.||||.|| .|..|.|| .  | .|.  ... .|.||. ||..  |. |  .|. ||
csagvgrtgvyivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_PTPN1_pd Subfamily PTPN1 712-974 3.5e-61 201.5 In-house 7-275 (290) alignment 
Range on Protein: 712-974
Range on HMM: 7-275/290.0
EWQALCA---YQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSpsrsDYINASpIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVM
 .....     .|.  ....|. . | ..||. |  ||||.||||. ..     |||||| ..| .     || |||||..|.. |||||||  .  .||
lykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinas.lveleeakrsyiltqGPlpntvdhfWqmvWeqkskavvm

LTPLVEDGVKQCDRYWPDEGA--SLY-H--VYEVNLVSEHIwCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNK--CYRGR
|  .|| .  .| .||| .    .|  .   ..|.|.||..  . . || . |.|..|||||....||...||  | | |   .|.|  || .  .    
lnkvvekeqikcaqywPqgeeekellledtklkvkliseer.ksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslssd

SCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVK--EIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAIL
  | ..||| | ||.||..|.| .| .. |  .   .||  .| ..| .| ||.. .||..|. .|. | .. | 
vGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvik
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 712-968 1.9e-58 192.9 In-house 29-277 (315) alignment 
Range on Protein: 712-968
Range on HMM: 29-277/315.0
EWQALCAYQAEPntCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIiEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTP
.....   |  |    .|.   | .|||. . ..||..|..| .    . |||.||. | .   .   |||.|||.  .. |||..|.|  .. ||||| 
dyesipggqlhp..ldvakkienkqknryiniiaydksrvqlpllendphsdyvnanfi.dGynkkrryiaaqgpnvasvkdfwrlvfeedigkivmltn

LVEDGVKQCDRYWPDEgASLYHVYEVNLVSEHIWcEDFLVRSFylKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSD
|||.  .....||||.   .|  . | ..|| .  ... ||..    |  .. |.. |.|. |||  | |..| ||... |.|..      ..|.||||.
lvegekrkaekywpdk.kviyGkitvtrkseevn.teytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhhtnsvgaivvhcsa

GAGRTGTYILIDMVLNRMaKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE
| |||||.| .| ||... .  . ||.   .. ||..| ..|.. .|..|   |. |
GvGrtGtfitldavldqa.eaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 712-970 4.4e-56 185.2 In-house 29-284 (297) alignment 
Range on Protein: 712-970
Range on HMM: 29-284/297.0
EWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPrmpAYIATQGPLSHTIADFWQMVWESGCTVIVMLTP
. . ||  .|.  .  .|.   |..|.|. . ||||  |.||..  .   |||.||| .         .|.|| |   |.||||.||..   ..||||. 
seeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnd

LvEDGVKQCDRYWPDEGASLYHVYEVNLVSEHiWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPA--STRPLLDFRRKVNKCYRGRSC-PIIVH
. ... |.| |||.|.| . .    | | | .  .| |. |.. ... ... .| . |..|..|| .  .   |.. ||..   |.| . ...  |..||
d.nerdkkcaryWsdkgvttfGdvsvvllsvs.ereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvh

CSDGAGRTGTYILIDMVLNRmAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV
|. | |||| .. || |. . ||  ||.||  .....|..|| ||. |.|..|   || | .
claGvGrtgvlltidsvvae.akrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_CG7180_pd Subfamily CG7180 712-969 3.5e-52 171.9 In-house 20-289 (296) alignment 
Range on Protein: 712-969
Range on HMM: 20-289/296.0
EWQALCAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIiEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTP
. .   . . | ..||.. .. |..|||... .|||..|. |.     ..||||||. . .   .  .|| |..|  .|. .||..|.. ..  .|.|| 
klelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyv.dsflkkkeyivteapkketvdefWrlvydeeisavvvLtk

LVeDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCeDFLVRSFYLKNV----------QTQETRTLTQFHFLSWPA-EGTPASTRPLLDFRRKVNKcYRG
   |  |..  ||| ..   |   .|..|.|. .  ..  | | |.             . |||....|..  |.  .  | ||  |...||.|.. .|.
tf.dfakmypsywpnkskeqygeifveiveekqya.nlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielrrrvrl.wre

R------SCPIIVHCSDGAGRTGTYILIDMVLNRMAKgVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEE
.        |..|..||||.|.| |. ||. |. . |  .|.|.   .  .| .||.|| ..... .    . | 
kvdedpeegPvvvvssdGasRsGvylaidanlelvek.eeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 717-897 9.1e-32 105.1 In-house 16-196 (297) alignment 
Range on Protein: 717-897
Range on HMM: 16-196/297.0
CAYQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKveSSPSRSDYINASPIIEHDPRM-PAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVED
   .|.... ..|. .. ..|||. | | .| .|.||.   ... .|||||  ..  |      || .||||| |. |||..|.| .  ||||.. | ||
lldeargesfssakrnsslrknryrdilatddtrvkll..rviterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrvivmvaklqed

GVKQCDRYWPDEGASLYHVyeVNLVSEHI--WCEDF-LVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKC
| ..|  |||.      .    ..| |..    ..|  |    |. .  .|.| ..   |||||  | |.    |  |. .|  |
Grdkcapywpsvvqerlka..gdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcsc
subfamily_PTPRK_pd Subfamily PTPRK 719-968 1e-65 216.7 In-house 28-275 (314) alignment 
Range on Protein: 719-968
Range on HMM: 28-275/314.0
YQAEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIiEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVK
|.. ..   .|. . | .|||  | |.||..|..|..    . ||||||. | .   |  |.|.||||| .|..|||..|.. .|. ||||| ||| |  
yeslfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaali.dsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrv

QCDRYWPDEGASlYHVYEVNLVSEHIWcEDFLVRSFYLKN--VQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRT
.| .|||...   |   .|.||. ..  ....|| | ...   . .|.|.. ||.||.||. ..| | . ||.. |.|.|    .  .|.|||| |||||
kClkyWPedtev.ygdikvelvetell.aelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrt

GTYILIDMVLNrMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE
||.| ||.||. |..  . .|.  .   .|.... .|  ..|. |   .. |
Gtfiaidivld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_PTPN3_pd Subfamily PTPN3 719-967 3.4e-65 214.8 In-house 25-272 (280) alignment 
Range on Protein: 719-967
Range on HMM: 25-272/280.0
YQAEP-NTCATAQGEGNIKKNRHPDFLPYDHARIKLKveSSPSrsDYINASPIIEHDPR---MPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVE
|. .|  .. .|.   |..|||. | ||||..|.|||  .|..  |||||. .    |    .  ||||||||..| .||||||||  ...||||| |||
yrkkpglaisaarkpenlsknryrdilpydatrvklk..eset..dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlve

DGVKQCDRYWPDEGASL-YHVYEVNLVSEhIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGA
.| ..| .|||... .| |  ..|.. .|    . ...| ..||. .|.| |...|. .|.|| .| | ..  .|.| ..|.|. .|.. |..|||| | 
rGrvkChqyWPetedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGi

GRTGTYILIDMVLNrMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVA
|||| .||... |  .    ... . . . ..||||  ||....|..|   |. 
grtGvlilletala.lieaaepvypldivrtmrdqramlvqtasqykfvCeail
0045098 (Phosphotyrosine protein) phosphatases II 721-970 2e-74 245.8 In-house 20-272 (278) alignment 
Range on Protein: 721-970
Range on HMM: 20-272/278.0
AEPNTCATAQGEGNIKKNRHPDFLPYDHARIKlkvesspsrsDYINASPIIEHdPrmPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQC
  |... .|. .||..||| .|.||||| |.|          |||||| |  . |  ...||||||| .|.||||.|.|| |.|||||||.|||.|.. |
gipseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy.p..kkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekc

DRYWPDEGASLYHVYEVNLVSEHIWcEDFLVRSFYLKNV----QTQETRTLTQFHFLSWPAEGTPAST--RPLLDFRRKVNKCYR-------------GR
..|||..|   |. ..|.|.||... .|. .| ... |.    .. |.|..|..|.|.||  |.| ..  ...|.. . ......             ..
aqywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllssllllds

SCPIIVHCSDGAGRTGTYILIDMVLNRMakGvKEIDIAATLEHVRDQRPG-LVRSKDQFEFALTAVAEEV
..|..|||| | |||||.......| ..  . . .|.  .....| ||||  | ...|..|   ...| .
ggpvlVHCsaGvgRtGtlvaaylmlell..e.ggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 721-881 4.3e-14 46.7 In-house 83-236 (244) alignment 
Range on Protein: 721-881
Range on HMM: 83-236/244.0
AEPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSpsRSDYINASpIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTplvedGVKQC
 .|.    |    |  |||.   ||.|  |. |   |      ||||| ..    |   || || ||. |  |||.|. |    |.|.|       |.. 
pdpsvmkdafnpnnswknregaglpfdfnrvplskgsm..gntyinas.fvgclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlg.....sveee

DRYWPDEGAslYHVYEVNLVSEHIWCEDFL---VRSFYLKNVQTQETRTLTQFHFLSWPAEGTP
| ||||        || ..       ..|       . ..    .  ..|| |    ||..|| 
deywpdsep..lewyeeditvtltdrdefknikasnleiesdmneshqaltmfqisnwpsdgtt
0049772 (Phosphotyrosine protein) phosphatases II 722-973 1.1e-39 132.4 In-house 34-283 (314) alignment 
Range on Protein: 722-973
Range on HMM: 34-283/314.0
EPNTCATAQGEGNIKKNRHPDFLPYDhARIKLKVESSPSrSDYINASPIIEHdprmPAYIATQGPLSHTIADF----------WQMV--WESGCTVIVM-
 ..|. .|. . |..|||..|.||.|  | .|. ..  . ||||||| .  .     ..|||||||..|. ||          |.||  ..  . .||| 
peltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivms

--------------------LTPLVEDGvkqcdRYWPDEGASLYHvyevnlvSEHIWCEDFlvrsfylknvqtqeTRTLTQFHFLSWPAEGTPaSTRPLL
                    |..| . |      ... .   |..       .|. . |.|              .|.  ... . .| ...| ... ..
rdevladelsrLdaAlgKtpllildgng.....neptaadlellk.......eelydpelf..............erlgikylripvpDgsap.lledfd

DFRRKVNKCyrGRSCPIIVHCSDGAGRTGTYILIDMVLNRMakgvkEIDIAATLEHVRDQRP-----GLVRSKDQFEFALTAVAEEVNAI
.| . ....   .  |..|||..| |||||........ ..      .... .||.|| .||     |.... .|.|| | |. | .. .
eflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 722-814 1.6e-10 35.1 In-house 25-122 (347) alignment 
Range on Protein: 722-814
Range on HMM: 25-122/347.0
EPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESS-PSRS----DYINASPiIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVM-LTPLVE
 |. ..... | ...|||  |    | .|. |  | |  ||.     |||||  |  |     || || || .|. |||.||     | .|  . |  .
spskftsvewekslsknrskdvklidatrvvlspeksknsraddvetyinash.ikfdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepikd
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 723-946 5.4e-30 99.0 In-house 26-244 (281) alignment 
Range on Protein: 723-946
Range on HMM: 26-244/281.0
PNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVE-SSPSRSDYINASPIiEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCD
 . |.. .   | ||||. .    | .|..|||.      .||| |  |         || ||||   | ||||.|.|.   | ||||  ..|   ..| 
sdlctvfnqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyi.rspflkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekca

RYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSfYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVnkcyRGRSCPIIVHCSDGAGRTGTYIL
 |.| .     .. .. .  |    .  || .  |.     ||| .|.. .  ||    | |.  .|   ||.    | || | ..||| | ||.|| . 
eyfprnahcclqfdklsvsyedstvnkslvtt.rlnlsyegetrlithwlwkewpdwqvpessevmlkilrki....rarstppvihcsagvgrsgtlma

IDMVLNRMAKGVKEIDIAATLEHVR
... |. .   .   ||   . |.|
veialqsihshftlpdikqivshlr
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 723-965 6.1e-28 92.6 In-house 24-265 (285) alignment 
Range on Protein: 723-965
Range on HMM: 24-265/285.0
PNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESspsrSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDR
|  |. .  | |   ||. |    . .|. ||        ||| || .        .||.|||||  |..|||.|...   . ..||  |.| ||..|  
ppnctytayeanpdlnryadvrcieetrvvlknhd....rdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekcal

YWPDEGASL--YHVYEVNLVSE-HIWCEDFLVRSFYLKNVQTQETRTLT--QFHFLSWPAEGTPASTRPLLDFRRKVNKCyRGRSCPIIVHCSDGAGRTG
|.|..   .  .  ||. |           .. .. . | .   .  |   . .   || . .|  .||.... . |.|    .  || |||| | ||| 
yypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv.npkekpicvhcsagvgrta

TYILIDMVLNRMAKGvKEIDIAATLEHVRDQRPGLVRSKDQFEFALTA
|.. ||    |. .   .|..   .  .|  |   |.|. || |    
tfvgidyatirimen.pniemldivremramrfqavqshmqflflyvv
0040439 (Phosphotyrosine protein) phosphatases II 725-968 5.3e-73 241.0 In-house 2-244 (249) alignment 
Range on Protein: 725-968
Range on HMM: 2-244/249.0
TCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIiEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYW
.. .|. . |..|||.||.||||| |.||.. ..   ||||||| | .   . ...|||||||..|..|||.|.|| |.|||||||.||| | ..|..||
eysvallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqyw

PDEGASLYHVYEVNLVSEHIwCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRG--RSCPIIVHCSDGAGRTGTYILI
|..|   |. . |.|.|... ..|. || ..|.|....|.|| .......||  |.| |. .|||| ..|.|...   ...|..||||.| |||||.|..
plggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaa

DMVLNRMAKGvKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE
...|... |  ...|.  .....|.|||| | . .|..| . |..|
ylmleqleke.lgvdleeavkllrsqRpgavqnpeqyrflyealle
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 725-969 7e-49 161.2 In-house 24-265 (283) alignment 
Range on Protein: 725-969
Range on HMM: 24-265/283.0
TCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSpsrsDYINASPII--EHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDR
 .  |  . | .|||. . .|.|  |..|| ||     |||||. |.  ... .   ||..|.|| .|. |||.||..   | |||||.| ||  ..| .
dadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmltklqedlrikCsq

YWPDEGASLYHVYEVNLVSEhIWCEDFLVRSFYLKNV-QTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYIL
||| .|.  |  . | |  |    . | .. . |..   ...|  |. . .  |   |  |    |. | . . .  . .  ||.|||| | |||...| 
yWPkrGsedyGeftvtlrke.ttsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhCstgiGrtavfia

IDMVLNRMaKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEE
.   .. . .    .|. |... .| ||...|...||. .  ..| |.
asasvkda.ltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 725-858 3.8e-25 83.4 In-house 38-184 (350) alignment 
Range on Protein: 725-858
Range on HMM: 38-184/350.0
TCATAQGEGNIKKNRHPDFLPYDHARIKLK--------VESSPSRSDYINASPII------EHDPRMpAYIATQGPLSHTIADFWQMVWESGCTVIVMLT
    ..|     |||. . |||.|.|.|||        .. | | .|||||. .       | .|    |||||.||  |. ||.... . . .||..||
DvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdf.kYiatqaPlpstvddfykvillnkvkvilslt

PLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCEDFLVRSFYLKN
..|| ....|.|||.. . . ..|   .   . .  .|   .|. .|.
sdvelnlekcyrYWqegsydditvklaskwenimgindsslysadvkk
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 725-970 1.6e-17 58.1 In-house 38-279 (303) alignment 
Range on Protein: 725-970
Range on HMM: 38-279/303.0
TCATAQGEGNIKKNRHPDFLPYDHARIKLkvesspSRSDYINASpIIEHDPRMPAyIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYW
. .  |   |..|||  | .  ||...||      | | || ||  .| | .  | | || ||||| ||||||. |    ....|    |      |  .
svsknqfvknmdknrfvdvicldhskvkl......sdssyihas.yleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvf

PDEGASLYHVYEVNLVSEHIWCEdfLVRSFYLKNVQTQ--ETRTL-TQFHFLSWPAEGTPASTRPL-LDFRRKVNKCYR--GRSCPIIVHCSDGAGRTGT
| .   |     .  | |    |  |.  . || .     . ...    |. .|| .  |. . |  .    ...   |    | | .     | ||.||
prnqdflkfeersirvgefkrve..lgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragt

YILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV
. |..     . .    .|.   || ||. |   |.   || .  | .|| |
falfetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_eak_pd Subfamily eak 725-883 6.6e-17 55.9 In-house 43-197 (332) alignment 
Range on Protein: 725-883
Range on HMM: 43-197/332.0
TCATAQGEGNIKKNrHPDFLPYDHARIKLKvESSPSRSDYINASpIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYW
.   ..   ....|   . .|||.  ..|   |   |  ||||| ..|       || |  .    .  ||||| |     ||.|   || .... |.|.
sisetarleavnrn.vvkivpydrylvrlt.ssqlnrlGyinas.laefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdkyf

PDEG--ASLYHVYEVNLvSEHIWCEDFLVRSFYLKnvQTQETRTLTQFHFLSWPAEGTPAS
||..     . ...|.   |..  . . .| . |.  .  ||  .  ...  |    .|  
pdktreelkfGildver.kefvkrniletrllels..kGnethrvlhykvfGwtettlpky
0037934 (Phosphotyrosine protein) phosphatases II 726-967 1.7e-67 222.8 In-house 2-239 (243) alignment 
Range on Protein: 726-967
Range on HMM: 2-239/243.0
CATAQGEGNIKKNRHPDFLPYDHARIKLkvessPSrSDYINASPIIEHdPRmpaYIATQGPLSHTIAD----FWQMVWESGCTVIVMLTPLVEDGVKQCD
...|. . |..|||..|.||||| |.||     .. ||||||. |    ||   .|||||||..|..|    ||.|.|| |.|||||||.||| |...|.
fsiallpenlsknrysdilpydhsrvkl.....eg.sdyinanliyvt.pr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekca

RYWPDEGasLYHVYEVNLVSEHIwCEDFLVRSFYLKNVQ-TQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKC--------YRGRSCPIIVHCSDG
.|||.|    |. ..|.|.||.  ..|. || ..|.|.. ...||. ...|.|.||  |.| |. .|||| ..|...        .. .. |..|||| |
qywpgev..tygdftvtllseeh.lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaG

AGRTGTYILIDMVLNRMakgvkEIDIAATLEHVRDQRPG-LVRSKDQFEFALTAVA
 |||||.|.....| ..     ..|.  .....|.||||  | . .|..|   |..
vgRtGtliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_egg_pd Subfamily egg 726-964 9.9e-23 75.3 In-house 32-264 (307) alignment 
Range on Protein: 726-964
Range on HMM: 32-264/307.0
CATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASpIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDgvKQCDRYWP
  ||  . | .| | .     | .|.||...      |.| |   .. .| .  .| .| ||  |  |||.||..  .  |||||  .|   ..|. |||
lttaasdnnlekarskrvhckdssrvklelrrGqylddfihan.rvkGkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywp

DEGASLYHVYEVNLVSEH--I-WCEDFLVRSFYLKNVQTQETRTLTQfhFLSWPAEGTPASTRPLldfrrKVNKCYRGRSCPIIVHCSDGAGRTGTYILI
   .    .   .|  |   .    | | |   || | ...     .     .  . .     ||     .| .  |  | |..|.. .|  ...| . |
kaesdslvtvpGslrienlkvdskadplfrvtklklvGgddeerfle..hwqgdvnnssdvyspl.....rvlrklrnlskpvvvqdilGvskaatlvai

DMVLNRMAKG-VKEIDIAATLEHVRDQRPGLVRSKDQFEFALT
.. |  . .| .    .  .   .| .|.  | |  .. |   
eiallsllrGpitkslvlravvflrlrrrlsvesvllylfvyr
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 727-959 3.4e-27 89.9 In-house 48-278 (305) alignment 
Range on Protein: 727-959
Range on HMM: 48-278/305.0
ATAQGEGNIKKNRHPDFLPYDHARIKLKvesSPSRSDYINASPIIehDPRMP--AYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYW
|    . .| |||. |    |.. .||.    || |||| |  .    | .|   .|..|||| .|| .|| || .     ||||   || |  .| .||
anqsadiaitknryqdvpcqdqsavkld...kpspsdyihanyvg..cpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqyw

PDEGASLYHV---YEVNLVSEHIWCE-DFLVRSFYLkNVQ--TQETRTLTQFHFLSWPAEGTPASTRPLLDFRrkvnKCYRGRSCPIIVHCSDGAGRTGT
|       ..     |. ||     | |  ..   | |.    ... .. ....  ||  | |      |..      . ||   ||.|||| | |||||
paaqgeklelksgivvenvsgskpmerdaeiqitll.nltysgdqkmsvrhlqwtewpdrgvppckltslell....sairgskvpivvhcsagigrtgt

YILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQF
 . |. .|...|.  .   .   .  .||||   ...  |.
ivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqy
0042113 (Phosphotyrosine protein) phosphatases II 728-967 3e-72 238.2 In-house 3-240 (245) alignment 
Range on Protein: 728-967
Range on HMM: 3-240/245.0
TAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIiEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDE
.|. . |..||| .|.||||| |.||.....   |||||||..   . . | .|||||||..|..|||.|.|| |.|.|||||...|.| ..|..|||..
vallpenkdknrysdilpydhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplg

GASLYHVYEVNLVSEHIwCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYR-GRSCPIIVHCSDGAGRTGTYILIDMVL
.   |. . |.|.||.. ..|. || . ..|... |.|. ...|.|.||  |.| ... |||| . |.|... ... |..||||.| |||||.|.....|
esltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylml

NRMAKGvKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVA
... |  .....  .....|.|||| | . .|..|   |..
eqleke.lgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 729-835 1.3e-13 45.0 In-house 43-164 (349) alignment 
Range on Protein: 729-835
Range on HMM: 43-164/349.0
AQGEGNIKKNRHPDFLPYDHARIKLKVESSPS--------------RSDYINASPI----IEHDPrmpAYIATQGPLSHTIADFWQMVWESGCTVIVMLT
..|     |||. | |||.|.|.|||    .|                |||||  .    |. .     ||||| ||  |. ||....   |  ... |.
seGvelfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvek...kyiatqaPlPstvddfykvillngvklvlsLn

PLVEDGVKQCDRYWPDEGASLYHVY
   | ....||.|| .   | ..| 
ddkelslekcdiywqelsysnitvk
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 730-971 6.6e-66 217.0 In-house 5-243 (250) alignment 
Range on Protein: 730-971
Range on HMM: 5-243/250.0
QGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRmPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKqCDRYWPDEGA
.   | .|||. |....|..|. |. |..   ||||||| .  .| |  |.|||||||..|| |||.||.|   ..||||| |.| . . . .||| |.|
kkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPveka

SLYHVYEVNLVSEHIWCeDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRG-RSCPIIVHCSDGAGRTGTYILIDMVLNR
  |    |.| |....  |. .| . | . . .. |.. |.||..||  | |. ..  |....||..  .   . |.||.|| | ||.|..| || ||.|
ekyGdvtvsllskeefa.dytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavler

MaKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVN
. |  | .|.   .. .| .||. |.|..|. |  ... . ..
l.kkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 730-970 6.9e-42 138.4 In-house 44-279 (439) alignment 
Range on Protein: 730-970
Range on HMM: 44-279/439.0
QGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIE-HDPRMpaYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDgVKqcdrYWPDEG
  | .  |||. |  ..||.|. |.       | ||||  |   .|...  |||||||  .|  |||..|.|  .. ||||| |||   |    ||| ..
aqeydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyyddkl..yiatqgpkkettddfwrlviekktvtivmltnlves.yk....ywpsda

ASLYHVYEVNlVSEHIWCEDFLVRSFYLKN--VQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRS-CPIIVHCSDGAGRTGTYILIDMV
   |    |  |   |   .. .| | . |   .|.  ||. |||...|| .  || .  .||| | .| .   .   |..|||| | ||||| | .|. 
evcygdiavr.vdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsandkeeygpvvvhcsagvGrtGtiialdia

LNRMaKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV
|... |  ...||   .. .|.||  .|..  |. |   || |..
leql.klenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 731-959 2.3e-34 113.4 In-house 53-272 (290) alignment 
Range on Protein: 731-959
Range on HMM: 53-272/290.0
GEGNIKKNRHPDFLPYDHARIKLKvesSPSRSDYINASPIIEHDprmPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGAS
 . ..||||. |    | .|. ||        ||. |  .   .   . .| |||.|  |. |.|.|| . . ..||||  |.|||  .|..|.|..   
kntefkknrykdvvcndktrvilk...dGydGdyvhanyvkGlk...amfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypekeGe

LYHVYE--VNLVSEHIWCEDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVnkcyRGRSCPIIVHCSDGAGRTGTYILIDMVLNR
     |  |    |.   ..   . . ......     |  ..  |||    . ||  ||   | .    |  | |..|||| | |||||.. |.. |. 
vltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril....rkasGpvvvhcsaGiGrtGtfvaievglqi

MAKGvKEIDIAATLEHVRDQRPGLVRSKDQF
. .| ||.|.. .   .|. | . |.   |.
lldG.keldlldlvralrnsrlnsvqvdiqy
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 732-970 2.6e-56 185.7 In-house 26-268 (274) alignment 
Range on Protein: 732-970
Range on HMM: 26-268/274.0
EGNIKKNRHPDFLPYDHARIKLKVESSPSR-SDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGAS
 |. .|||. . || ...|. |. ||| .  |.||||  |   | .  ||.||||||..|.||||.|...  ..|||||| | |   ..| .|.||.   
fgsqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedy

----LYHVYEVNlVSEHIWCEDFLVRSFYLKNVQTqeTRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGR---SCPIIVHCSDGAGRTGTYILID
     |   |.. |.. . ..|. ||...||...   .|... . . .|| . .| ....|||. ..|..  . .     |..|||| | |||| .| |.
eiserygdveik.vekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiais

MVLNRMAKGvKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV
. .... .  . .|.  .  ..| .| |.|....|.|.   |... .
iavrqlree.ivvdvlkivcnlrldrGGmvqtseqyelihralclyl
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 732-967 2.7e-53 175.6 In-house 6-238 (239) alignment 
Range on Protein: 732-967
Range on HMM: 6-238/239.0
EGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEgASL
  |  |||. . . |||.|. |.  |   .||||||| . ..|    ||||||| .. .  |||.|.|.    |||||| |.|   |.| .||||  .| 
rvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tsk

YHVYEVNLVSEHIWCeDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLnRMAK
|    | |    ... |...|.| . .|   | | . |.||  || .| |  .  .| .|||. |     . | ..||| | ||||....|| .| | ||
ycnlrvtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml.rqak

GVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVA
  | .||   .. .|..|| .|.. .|. |   || 
kqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 733-968 2.3e-53 175.8 In-house 6-238 (239) alignment 
Range on Protein: 733-968
Range on HMM: 6-238/239.0
GNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEgASLY
 |  |||. . . |||.|. |.  |   .||||||| . ..|    ||||||| .. .  |||.|.|.    |||||| |.|   |.| .||||  .| |
vnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpds.tsky

HVYEVNLVSEHIWCeDFLVRSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLnRMAKG
    | |    ... |...|.| . .|   | | . |.||  || .| |  .  .| .|||. |     . | ..||| | ||||....|| .| | || 
cnlrvtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidaml.rqakk

VKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE
 | .||   .. .|..|| .|.. .|. |   || |
qktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 733-972 7.1e-50 164.5 In-house 19-266 (270) alignment 
Range on Protein: 733-972
Range on HMM: 19-266/270.0
GNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGAS--
 . | ||. | ||  ..|..|. ... |.. ||||  .   | .  .|||..|||  |. .||.|.||.  | |||.|.|.|.| |.|.|||| |  .  
rgkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpaepkekv

LYHVYEVNLVSEHIW-CEDFLVRSFYLKnvQTQETRTLTQFHFLSWPAEGTPASTR------PLLDFRRKV----NKCYRGRscPIIVHCSDGAGRTGTY
 ..  ... ....    | ....   |.  .. |.| |. |.. .|| .| | ..        ||   |.|    ..  ..   |..||||.| ||||| 
kledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae..PllvHcsaGvgRtGtl

ILIDMVLNRMAKGvKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNA
|..|.... . .  |..|..| .|..| .|. ||.  .|.||.  ||.| .. 
ialDiavrlLeet.kkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 733-970 8.2e-29 95.5 In-house 42-271 (288) alignment 
Range on Protein: 733-970
Range on HMM: 42-271/288.0
GNIKKNRHPDFLPYDHARIKLKvesspSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEG-ASL
.|  ..|. .    | .|.||.       .|.  |. ..   .     | .| ||  ||  .|.|. ||.   ||||. |.| | .. . |.| .   . 
anptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGeka

YHVYEVNLVSEHIWCEDFLVRSFYLKNVQTQETRT-LTQFHFLSWPAEGTPASTRPLLDFRRKVnkcyRGRSCPIIVHCSDGAGRTGTYILIDMVLNrMA
      . | ..    | ||.   |.. .. |..  . . |.| |. .| | .  . | .   .    .    ||.||.| |.||||| ||| ..|. ..
rigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililiale.sl

KGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV
. .  . |   |.. |..|   .... |. ..   | ||.
rlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_CG42327_pd Subfamily CG42327 733-891 1.2e-25 84.8 In-house 27-187 (319) alignment 
Range on Protein: 733-891
Range on HMM: 27-187/319.0
GNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPD----EG
.  .|.|  . .|  ..|. |.  ..  .. |..|| .  .|     |||.| .|  . .|||..|||    ||| || | | |.|.| .|.|     ..
tskdksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldn

ASLYHVYEVNLVSEHIwCEDFLVRSFYLKNVQTQETRTLTQFHFlSWPAEGTPASTRPLLDFR
 |||  . | |    .  . ... .. ||.|. .|.| || . .  |.  . ||. ..|.   
tslyGdilvtlkgrev.kdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliaml
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 733-829 2.3e-06 20.7 In-house 26-89 (169) alignment 
Range on Protein: 733-829
Range on HMM: 26-89/169.0
GNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINAspiiehdprmpayiatqgplshtiadfwQMVWESGCTVIVMLTplvedGVKQCDRYWPDEGA
 |  |||    |   |.|.||.       ||||||                            .|.||.  .|||.|      .  . . .||.   
cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlg.....dtddknnfwpeked
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 733-811 2.8e-06 21.0 In-house 33-109 (332) alignment 
Range on Protein: 733-811
Range on HMM: 33-109/332.0
GNIKKNRHPDFLPYDHARIKLKVESspSRSDYINASPIiEHDPRMPAYIATQGPLS-HTIADFWQMVWESGCTVIVMLTP
 |.  || | .  .||.|..|  .    . |. ||| . .   .  ||| .| |.  ||   ||.|| |   ..|...  
nnmdmnriphlycfdhsrvelapqd..gkddfynaswv.dgyskksayifaqapfndhteyvfwrmvserkpsmilvfgd
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 733-829 3.3e-06 20.1 In-house 25-88 (169) alignment 
Range on Protein: 733-829
Range on HMM: 25-88/169.0
GNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINAspiiehdprmpayiatqgplshtiadfwQMVWESGCTVIVMLTplvedGVKQCDRYWPDEGA
 |  |||    |   |.|.||.       ||||||                            .|.||.  .|||.|      .  . . .||.   
cnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlG.....dtddknnfwpeked
Y_phosphatase Protein-tyrosine phosphatase 734-968 5.4e-76 250.5 Pfam-A 1-235 (235) alignment 
Range on Protein: 734-968
Range on HMM: 1-235/235.0
NIKKNRHPDFLPYDHARIKLkvESSPSRSDYINASPIIEHDpRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWP--DEGASL
| ||||..|.||||. |.||  ..|...||||||. .  .. .  ..|||||||..||.|||.|||.  ..|||||| |.| | ..|..|||  .|.   
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YHVYEVNLV-SEHIWCEDFLVRSFYLKNVQTQ-ETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRM
|. ..|.|. .|. ..... .| . ||. ... |.|...|.|. .|| .|.|.|...|||. |||.|  . .| |..||||.|.|||||....|..|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

AKGVKeIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE
 .. . .|.  .....| ||||.| | .|..|   |..|
eaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 734-968 5.4e-76 250.5 In-house 1-235 (235) alignment 
Range on Protein: 734-968
Range on HMM: 1-235/235.0
NIKKNRHPDFLPYDHARIKLkvESSPSRSDYINASPIIEHDpRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWP--DEGASL
| ||||..|.||||. |.||  ..|...||||||. .  .. .  ..|||||||..||.|||.|||.  ..|||||| |.| | ..|..|||  .|.   
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YHVYEVNLV-SEHIWCEDFLVRSFYLKNVQTQ-ETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRM
|. ..|.|. .|. ..... .| . ||. ... |.|...|.|. .|| .|.|.|...|||. |||.|  . .| |..||||.|.|||||....|..|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

AKGVKeIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE
 .. . .|.  .....| ||||.| | .|..|   |..|
eaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 734-964 2e-56 185.9 In-house 3-233 (237) alignment 
Range on Protein: 734-964
Range on HMM: 3-233/237.0
NIKKNRHPDFLPYDHARIKLKVESSPsrSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDE-GASLY
|  |||. .   |||.|. ||   |   ||||||. . . |     |||.||||  .  |||||||.  |.|||||| |.|   ..| .|||.    . |
nkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaay

HVYEVNLVSEHIWcEDFLVRSFYL-KNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKV-NKCYR-GRSCPIIVHCSDGAGRTGTYILIDMVLnRM
 |. | |  .  .  |. |||. | |... .| | . |..| |||  | |  |  || ||... |.     .|.| |.||| | |||| ...|| .| | 
gvltvslkkkeef.sdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml.rq

AKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALT
||  | .||   .  . ..|| ....|||. |   
akekkvvdiynyvysieedrpyiiqtkdqyvfihq
0041856 (Phosphotyrosine protein) phosphatases II 734-968 2.3e-44 146.5 In-house 1-169 (182) alignment 
Range on Protein: 734-968
Range on HMM: 1-169/182.0
NIKKNRHPDFLPYDHARiklkvesspsRSDYINASPIIEHDPRMPaYIATQGPLSHTIADFWQMVWESGCTVIVMLTplvedgvkqCDRYWPdegaslyh
|..|||..|.||||| |           .|||||. ..   | .  .||||||| .|.|||..|..| |.|.||.||         ...|||        
nldknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

vyevnlvsehiwcedflvrsfylknvqTQETRTLTQFHFLSWPAEGTPAsTRPLLDFRRKVNKcyrgRSCPIIVHCSDGAGRTGTYILIDMVLNRmakgv
                           . ..|. .|...|.||  |.|  .. |||| ..|..    ...|..|||| | |||||........ .     
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....

kEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE
 ....  ....|| .||| | . .|. |   |. |
.gvsleeavklvrsrRpgmvitpnqyfflqlalle
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 734-962 5.4e-27 89.3 In-house 48-279 (305) alignment 
Range on Protein: 734-962
Range on HMM: 48-279/305.0
NIKKNRHPDFLPYDHARIKLkveSSPSRSDYINASPIiEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYH
. .|||. |    |. |.||    .|   .|| |  .         .| || || .| |||| | ..     | ||  |.| | |.|  |.. .     .
eagknrykdvgcldnnrvkl...egpwpheyihanyv.stptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdvle

VYEVNLvSEHIWCEDFLVR------------SFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVnkcyRGRSCPIIVHCSDGAGRTGTYIL
  | .     . .|                 .  . .   ...|  |..|.  ||  | ||.   .|..  |     |    ||.|||| | ||||. ..
feekgq.kisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtgsvvm

IDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFA
.. .|...  | .  |    | ..|.||   ... .|. | 
leyildqllagqiiedtdkilqkireqrnnsiqtdaqylfv
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 744-881 2.7e-10 34.6 In-house 3-127 (130) alignment 
Range on Protein: 744-881
Range on HMM: 3-127/130.0
LPYDHARIKlkvesspsRSDYINASPIiEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTplvedGVKQCDRYWPDEGAslYHVYEVNLVSEH
|... .|..          .||||| .     |   |. || ||. |  |||.|. |    |.|.|       |.. | ||||     .. || ...   
lefevsrlq........gntyinasfv.Gllgrtaeylltqhpladtsmdfwkmmleryvnvlvvlg.....sveeedeywpdseP..lewyeediivtl

IWCEDF-LVRSFYLKNVQTQE--TRTLTQFHFLSWPAEGTP
   ..|  ... .|.  .      ..|| |.   ||..|| 
tdrdefknikasnleiesdlneshqaltmfqisnwpsdgtt
0044763 (Phosphotyrosine protein) phosphatases II 745-961 4.4e-32 106.5 In-house 1-162 (178) alignment 
Range on Protein: 745-961
Range on HMM: 1-162/178.0
PYDHARIKLKVESSPSRSDYINASPIIEHdprmpAYIATQGPlshtiADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGAslyhvyevnlvsehi
|.|. | .|   . . |||||||| |...      |.....|     ||......| |.|.||.||. .| |  .||.|||.|                 
pldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag...............

wcedflvrsfylknvqtqetrtlTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLNRmakgvkEIDIAATLEH
                        |.... .|  |.| ... .|.| . .....  . .|..|||| | ||.|| ....... .       ... . .|.
.......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaiel

VRDQRPgLVRSKDQFEF
|| .||  | . .| ..
vrerRp.ivpnpgqlrq
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 748-966 1.5e-16 55.4 In-house 32-255 (290) alignment 
Range on Protein: 748-966
Range on HMM: 32-255/290.0
HARIKLKVESSPSRSDYINASPIIEhdPRMPAYIATQGPLSHT-------IADFWQMVWESGCTVIVMLTPLVEDGVK----QCDRYWPDEGASLYHVYE
..|. ||.  .   .||| |. ..   |   . |.|| |. ..       | .|| |. .   . .|||    |   .    .| .| |..      .  
atrvvLkgygkrfnddyiHAnrvtc..pnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkfkg

--VNLvSEHIWCEDFLVRSFYLKNvQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNkCYrgrSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVK
  |.   . .  .|. .|   .|  . .|  |.|   . .|    .. .|. ||.  .||. ..     |.|||| ||  |  .   |..    .|.  .
ltvkC.kskekeddvetRelvvkf.ddeeeftvtHsllkgWnklnvqedtktllsliqkvk.as...ktpvivHcvdGiSrsAalaaiilgyQkiaetsg

EIDIAATLEHVRDQRPGLVRSKDQFEFALTAV
.. ... |. .| ||  .. |. .. |.. ..
svkledvlkalrkqralaitsalelafvdagi
0051429 (Phosphotyrosine protein) phosphatases II 761-972 3e-42 140.5 In-house 3-227 (272) alignment 
Range on Protein: 761-972
Range on HMM: 3-227/272.0
RSDYINASPIIEHdPR---MPAYIATQGPLSHTIADFWQMvWESGCTVIVMLTPLVEDGVKQCDRYWP------------DEGASLYHVYEVNLVSEHiW
 |.||||. .     |     ......||| .|.||||.. .| |...||.|....| |  .||||||            ..   ||. . | |.||. .
lsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee.l

CEDFLVRSFYLKNV-QTQETRTLTQFHFLSWPAEGTPASTrpLLDFRRKVNKcyrgrSCPIIVHCSDGAGRTGTYILIDMVLnRMAKGVKEID-------
..|...| ..|... ...|.|.....|...||  |.| ..  ||.. . ...     . |..|||| | .||||.......| .       .|       
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnl

-IAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNA
 .....|..|.|||| | . .|..| . |..| ...
yleeaveelraqrpgavqteeqylflyeallellrs
0043147 (Phosphotyrosine protein) phosphatases II 761-962 1.2e-37 124.6 In-house 4-153 (172) alignment 
Range on Protein: 761-962
Range on HMM: 4-153/172.0
RSDYINASPIiEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLvedgvkqcdrywpdegaslyhvyevnlvsehiwcedflvrsfylKNVQ
.|||||||.. .    .. .|||||||..|.||||.|..| |.|.||.||.|                                             .  
gsdyinasyl.dlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lydp

TQETRTLTQFHFLSWPAEGTPaSTRPLLDFRRKVNK-CYRGRSCPIIVHCSDGAGRTGTYILIDMVLnrmakgvKEIDIAATLEHVRDQRPGLVRSKDQF
....|.  |...|.||  |.| ... ||.| . ... . . ...|..|||| | ||||| ......|       . ...  ....||..||| | ...| 
ellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsqy

EFA
 | 
rfl
0046846 (Phosphotyrosine protein) phosphatases II 761-964 6.7e-36 119.0 In-house 11-167 (176) alignment 
Range on Protein: 761-964
Range on HMM: 11-167/176.0
RSDYINASPIIEHdprmpAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYhvyevnlvsehiwcedflvrsfylknvq
 .|||||. |. .     ..||||||| .|.|||..|..| |.|..|.|| .|| |  .|..|||.. .  .                            
dldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi............................

tqetrtltQFHFLSWPAEGTPAStRPLLDFRRKVNKCYRGRsCPIIVHCSDGAGRTGTYILIDMVLNRmakgvKEIDIAATLEHVRDQRP-GLVRSKDQF
        |...| ||  |.| . . ||.. . ......    |..|||| | |||||.......  .     | ...  .|..||.||| | | . .| 
........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllele.....kglsveealalvreqRplgavqtpeQy

EFALT
.|   
rflye
0036282 (Phosphotyrosine protein) phosphatases II 762-961 1.1e-35 118.3 In-house 2-161 (174) alignment 
Range on Protein: 762-961
Range on HMM: 2-161/174.0
SDYINASPIiEHDPRMPAYIATQGPLShtiadFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDegaslyhvyevnlvsehiwcedflvrsfylknVQT
||||||||.     . | .||.||||.     ||.|..| |.|..|||....|.|   | .|||.                                 ..
sdyinaspl.dlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

QETRTLTQFHFLSWPAEGTPASTRpLLDFRRKVNKCYRG-RSCPIIVHCSDGAGRTGTYILIDMVLNRMAkgVKEIDIAATLEHVRDQRPGLVRSKDQFE
 ..|.  |...| ||  |.| ..  ||.| . |....   ...|..|||| | ||||| ......| ..    . .|. ...  .| |||| | . .|..
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyr

F
|
f
0051082 (Phosphotyrosine protein) phosphatases II 762-965 4.5e-33 109.3 In-house 3-148 (151) alignment 
Range on Protein: 762-965
Range on HMM: 3-148/151.0
SDYINASPIIEHdprmpaYIATQGPLShtiaDFWQMVWESGCTVIVMLTPLVEDGvkQCDRYWPDEGaslyhvyevnlvsehiwcedflvrsfylknvqt
|||||.| . ..      .....|||.    ||.....| |...||.|....| |   | .|.|..|                                 
sdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg.................................

qetRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKcyrGRSCPIIVHCSDGAGRTGTYILIDMVLNRmakgvkeIDIAATLEHVRDQRPGLVRSKDQFEF
   ........|.||. |.| |.  .|.| .....    .. |..|||| | ||||| ......| .       ......||..| .|||.|....|| |
...ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqflf

ALTA
 | |
qlfa
0049260 (Phosphotyrosine protein) phosphatases II 776-962 1.1e-37 124.5 In-house 7-142 (152) alignment 
Range on Protein: 776-962
Range on HMM: 7-142/152.0
RMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWpdegaslyhvyevnlvsehiwcedflvrsfylknvqtqetrtltQFHFLSW
.. ..||||||...|.||||.|..| |.|.||||| |.|.|  .|..|.                                            |...| |
mpfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhlpw

PAEGTPASTRPLLDFRRKVNKCYRGRSCPIIVHCSDGAGRTGTYILIDMVLnrmakgvKEIDIAATLEHVRDQRPGLVRSKDQFEFA
|  |.| ..  ||.. . ..|... ...|..|||| | |||||.......|       . ...  ....|| .||| | ...| .| 
pDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfl
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 778-959 2.1e-26 87.3 In-house 90-270 (301) alignment 
Range on Protein: 778-959
Range on HMM: 90-270/301.0
PAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHV--YEVNLVS-EHIWCEDFLVRSFYLKNVQ-TQETRTLTQFHFL
  .|||||||. |  ||| |.       ||||.  ||. ...|. | | . ..  ..  ....... |.|  ..   |.. ...     .|||.| . . 
hrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtlevedstgkfatrtvthyqys

SWPAEGTPASTRPLLDFRRKVNKCYRgrscPIIVHCSDGAGRTGTYILIDMvLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQF
.|...|.| |   | |.   | |  .    ||.||||.| ||. ..|  .. | |  .  ..|... .|.|.|..|   |. . |.
ewtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigtey.lareveadptieltealkhlrehrwngvqtnsql
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 778-829 1.7e-07 25.0 In-house 236-284 (440) alignment 
Range on Protein: 778-829
Range on HMM: 236-284/440.0
PAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEdgvKQCDRYWPDEGA
 |.|||| ||  |. |||..| .   . |.||  | .   | |  ||| .  
nafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpvntr
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 779-962 8.6e-24 78.8 In-house 5-195 (198) alignment 
Range on Protein: 779-962
Range on HMM: 5-195/198.0
AYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIW-CEDFLVRSFYLKNVQTQ--ETRTLTQFHFLSW
 ||||| || .|.|||||||||.|   |||.     .   .   |||   ..  .   ...... |    |. . .. | |  |    || .... | ||
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PAEGTPASTR--PLLDFRRKVNKCYR-GRSCPIIVHCSDGAGRTGTYILIDMVLNRMA-KGVKEIDIAATLEHVRDQRPGLVRSKDQFEFA
    ||  .    ..   |.| | |   . .|.||||||| | || .. .|. .          .|.      .|. | |.. | ....| 
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 779-962 8.7e-24 78.8 In-house 6-196 (199) alignment 
Range on Protein: 779-962
Range on HMM: 6-196/199.0
AYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIW-CEDFLVRSFYLKNVQTQ--ETRTLTQFHFLSW
 ||||| || .|.|||||||||.|   |||.     .   .   |||   ..  .   ...... |    |. . .. | |  |    || .... | ||
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

PAEGTPASTR--PLLDFRRKVNKCYR-GRSCPIIVHCSDGAGRTGTYILIDMVLNRMA-KGVKEIDIAATLEHVRDQRPGLVRSKDQFEFA
    ||  .    ..   |.| | |   . .|.||||||| | || .. .|. .          .|.      .|. | |.. | ....| 
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynfi
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 786-968 2.1e-16 54.2 In-house 99-286 (302) alignment 
Range on Protein: 786-968
Range on HMM: 99-286/302.0
PLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDE--GASLYHVYEVNLVSEHIWCEDFL------VRSFYLKNVQTQ--ETRTLTQFHFLSW
|   |.  .| .. .   ...| |. .|||. |.|  |. |.  |   .  | |. || .   |.|       . .  .|| ...    .|.  ..| .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

PAEGTPASTRPLLDFRRkVNKCYRGRscpIIVHCSDGAGRTGTYILIDMVLNRMAKgVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE
|  |.|. . . ||  .   ..|.     ..|||| | ||||| . |   ..  .|  |  |..  .  ||. | | |....|  . |  |. 
pdhGapkeaytaldilk.fcesykkn...vlvhcsaGvGrtGtlvaikyGiqlcsk.kkvtdllsivlpvrqcryGavqdeqqliylllcvtk
subfamily_hpo-7_pd Subfamily hpo-7 787-966 9.9e-22 72.1 In-house 43-223 (263) alignment 
Range on Protein: 787-966
Range on HMM: 43-223/263.0
LSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHIWCeDFLVRSFYLKNVQ--TQETRTLTQFHFLSWPAEGTPAST
|  ||. |.|..  .. .|.|||.   |.||..|..|.| |      . .||... ..   | |...  | ..    ..|.|.... .  |...  |  .
lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekndpela

RPLLdfrrKVNKCYRGRsCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVK-----EIDIAATLEHVRDQRPGLVRSKDQFEFALTAV
|  |    .. |  |.   ...|||| | ||.  . ....|  .| . ..     |.|    ||..| .|.. .    |. |..  |
reil....nilkvarns.kslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmv
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 788-966 3.2e-23 77.1 In-house 38-217 (255) alignment 
Range on Protein: 788-966
Range on HMM: 38-217/255.0
SHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGASLYHVYEVNLVSEHiWCEDFLVRSFYLKNVQT--QETRTLTQFHFLSWPAEGTPASTR
| |.. |.|..  .. .|.|||. . |.||..|..|.| |      . .||... .    | ..|   .    .  ..|.|.. ...  |... .|  .|
sltvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWieknaPelar

PLLDFRRKVNKcyrgrSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVK-----EIDIAATLEHVRDQRPGLVRSKDQFEFALTAV
 .|   . | .     | ...|||| | ||. ...|...|  .| . ..     |.|    ||..| .|.. .    |. |..  |
eilnilkvvrd.....sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmv
0038934 (Phosphotyrosine protein) phosphatases II 849-964 1.3e-08 30.3 In-house 45-171 (194) alignment 
Range on Protein: 849-964
Range on HMM: 45-171/194.0
FLVRSFYLKNVQTQETRTLT----------------QFHFLSWPAEGTPASTRPLLDFRRKVNKCYRG-RSCPIIVHCSDGAGRTGTYILIDMVLNrmak
.||| . |.||.     .||                ... | .|  ||. |.  ||.| . |.. ..   .. . |||  | ||||| .   ..      
dlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr....

gvKEIDIAATLEHVRDQRPGLVRSKDQFEFALT
    ..  . ....|. ||| ... |..|  |.
..lgmsaeeAialfrekRpgaipnqdyleallk
0048179 (Phosphotyrosine protein) phosphatases II 852-962 6.7e-19 63.5 In-house 34-137 (144) alignment 
Range on Protein: 852-962
Range on HMM: 34-137/144.0
RSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRgRSCPIIVHCSDGAGRTGTYILIDMVLnrmakgVKEIDIAATLEHVRDQRPG
 ..  .  .. ..|. .|...|.||  |.| ..  ||.| . ...... ...|..|||| | |||||........      .. ...  .|..|| .|||
inlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrrpg

LVRSKDQFEFA
 | . .|..| 
avpnpgqlrfL
0048076 (Phosphotyrosine protein) phosphatases II 854-964 4.6e-20 67.2 In-house 34-137 (145) alignment 
Range on Protein: 854-964
Range on HMM: 34-137/145.0
FYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRsCPIIVHCSDGAGRTGTYILIDMVLNrmakgvKEIDIAATLEHVRDQRPGLV
. | . .. ..|. .|...|.||  |.| ... ||.| . ......   .|..|||| | |||||.......|       . ...  .||.|| |||| |
lnltselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelvrsqrpgav

RSKDQFEFALT
 . .|..| . 
pnpgqlrflye
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 859-969 5.7e-19 62.8 In-house 83-193 (440) alignment 
Range on Protein: 859-969
Range on HMM: 83-193/440.0
VQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCY-RGRSCPIIVHCSDGAGRTGTYILIDMVLnRMAKGVKEIDIAATLEHVRDQRPGLVRSKD
..  |.||| |.|. .|| .| |  . |.| . . ||..  .  . |..|||| ||||||  | .| .| | ||   .||| . .. .|..|| .|.. .
ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsil.reakrsdqidifsfinsmrnnrpqmvqtpe

QFEFALTAVAEE
|. |   || | 
qyafvheavleg
PTPc_DSPc_SM00012 867-968 1.6e-29 97.6 In-house 2-105 (105) alignment 
Range on Protein: 867-968
Range on HMM: 2-105/105.0
LTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRGRS--CPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALT
....|...|| .|.| .. ..|.. |.|.|... ..   |..||||.|.|||||....|..|... |. ||.||  .....|.||||.|....|. | ..
vkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylflyr

AVAE
|..|
alle
subfamily_PTPDC1_pd Subfamily PTPDC1 870-961 1.7e-06 22.6 In-house 85-167 (182) alignment 
Range on Protein: 870-961
Range on HMM: 85-167/182.0
FHFLSWPAEGTPaSTRPLLDFRRKVNKCYRGRscPIIVHCSDGAGRTGTYILIDMVLNrmakgvKEIDIAATLEHVRDQRPGLVRSKDQFEF
.. ..|.  |.. | . .||  . |. . .     . |||  | ||||  |   .| .      |... . ... ||..||  .....| |.
vynfgwkDygva.sleriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvya......krltaekaiklvrskrpksiqtreqvel
subfamily_CG42327_pd Subfamily CG42327 899-965 2.3e-14 47.8 In-house 244-310 (319) alignment 
Range on Protein: 899-965
Range on HMM: 244-310/319.0
RGRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTA
| .  |..||||||.||||. |  |. .... .  . .||  .. .|| .|   |..|.|.||    
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 899-964 4.5e-09 30.5 In-house 259-338 (350) alignment 
Range on Protein: 899-964
Range on HMM: 259-338/350.0
RGRSCPIIVHCSDGAGRTGTYILIDMVLN------RMAKGVKEIDIA--------ATLEHVRDQRPGLVRSKDQFEFALT
  || ||.|||| | |||||.. .|..|.       . |  ...| |         .. ..| ||  .|...||| |   
narsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYe
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 900-970 9.2e-13 42.7 In-house 226-295 (297) alignment 
Range on Protein: 900-970
Range on HMM: 226-295/297.0
GRSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVkEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEV
 |. ...|||| | ||.|  .| |..|... |.    |.|| |...|.||. ||.. .|||.  .|| . .
prnayllvhcsaGvGrsGvvvlsdvilaklrkkr.ipdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 900-930 6.3e-07 23.0 In-house 263-293 (349) alignment 
Range on Protein: 900-930
Range on HMM: 263-293/349.0
GRSCPIIVHCSDGAGRTGTYILIDMVLNRMA
 .. ...|||| | ||||... .|..|. . 
dqlstllvhcsaGcGrtGvlvtldlllsile
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 906-969 2.6e-09 31.3 In-house 1-63 (69) alignment 
Range on Protein: 906-969
Range on HMM: 1-63/69.0
IVHCSDGAGRTGTYILIDMVLNRMaKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEE
.|||| |.|||||.| | . . |. |  | .||   ....|  || .|  .... |   |..| 
vvhcssGtGrtGtfiaimvemari.kseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 906-968 4.9e-09 30.5 In-house 2-63 (69) alignment 
Range on Protein: 906-968
Range on HMM: 2-63/69.0
IVHCSDGAGRTGTYILIDMVLNRMaKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAE
.|||| |.|||||.| | . . |. |  | .||   . ..|  || .|  . .. |   |..|
vvhcssgtgrtgtfiaimvemari.kseklvdifnnvqymrkcrpmmvmneieyifihdalve