Gene PTPRN2 in Homo sapiens

Synonym: IA-2beta, IAR, ICAAR, PTPRP, R-PTP-N2, PTPRN2

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family PTP
Subfamily PTPRN
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP106_AA protein Get Run
HsapP106_AA_727-1007 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
RESP18 RESP18 domain 73-137 8.3e-11 29.4 Pfam-A 15-74 (105) alignment 
Range on Protein: 73-137
Range on HMM: 15-74/105.0
EVSPVALQRLRVALQKLSGTGFTWQDDYTQYVMDQELADLPKTYLRRPeasspARPSKHSVGSER
..    |||| | ||.|   |. |.|| ||.|| |..  ...   . |      . ..... . |
glatpvlqrLqvvlqqlvpkglfWkDDltqevmaqkmerisrlrPqeP.....edrdgkaaaptr
Receptor_IA-2 Protein-tyrosine phosphatase receptor IA-2 508-597 2.6e-43 133.4 Pfam-A 1-90 (91) alignment 
Range on Protein: 508-597
Range on HMM: 1-90/91.0
EEARGYIVTDRDPLRPEEGRRLVEDVARLLQVPSSAFADVEVLGPAVTFKVSANVQNVTTEDVEKATVDNKDKLEETSGLKILQTGVGSK
||..||||||.|||..|||..|.|..|.|....||.|.|..||||||||||.||.|||.|.||.||.|..|||||...||||||.|||.|
eeefGYivtdkdpLsleeGlkLleilaelvklasssFidisvlGPavtFkvraneqnvstadvakaaveekdkLeketglkilqsgvgek
0050432 (Phosphotyrosine protein) phosphatases II 714-1010 2.7e-94 311.2 In-house 14-303 (308) alignment 
Range on Protein: 714-1010
Range on HMM: 14-303/308.0
WSEEPVQSNMDISTGHMILSYMEDhLKNKNRLEKEWEALCAYQAePNSSFVAQREENVPKNRSLAVLTYDHSRVLLkaensHSHSDYINASPIMDHD-PR
. ..... ..   . . .| ..|. .... .||.|.|.|....  ... .||...||..|||.  .| |||||| |     ...||||||| .. ..  .
frdtsilvsslklsvldllkllek.aldlglleeefeellsvkp.lleysvallpenkdkNrykdilpydhsRVkl.....degsdYInAsyvdgysskl

NPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDE---GSNLYHIYEVNLVSEHIwCEDFLVRSFYLKNLQTNETRTVTQFHFL
. ..|||||||| ||.|||.|||| .. |||||| | |||. .|..|||.|   ||  |. . |.|.||.. ..|. || ..|.||...|.||||.||..
prkfIatqgPlpntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseev.lddytvrtleltnlgdgesrtvthfhyt

SWYDRGVPSSSRSLLDFRRKVNKCYrgRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGaKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAI
.| | |||.| ..|||| ..|.|..  ...||.||||.| ||.||....|..|. . |. ...|.  .. .|| ||||||||.||..|   |..| .. .
nWpdhgvPpspeilldflelvrksl..pggpivVHCsaGvGRtGtfialdllleqleke.ggvdvfeavkklReqRpgmvqtpeqylflyralleylklk

L
|
l
0039614 (Phosphotyrosine protein) phosphatases II 714-1009 1.4e-88 292.5 In-house 3-292 (297) alignment 
Range on Protein: 714-1009
Range on HMM: 3-292/297.0
WSEEPVQSNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAEpnsSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSH-SHSDYINASPIMDHDPR
. .........|..... | .. .....|..|..|.| |. .. .     .|...||..|||.  .| |||||| || |...  .||||||| .  .| .
plrdallesipiplsvldlllllekansktllllefeellslkpd...ysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydll

NPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVrQCYHYWPDEGSnLYHIYEVNLVSEHIwCEDFLVRSFYLKNlqTNETRTVTQFHFLSWY
....|||||||| ||.|||.|||| |. ||||||.| |.|. .|..|||.||.  |. . |.|....  .... || . ..|  ..|.||||.|....| 
trkfIatqgPlpetvedFwrmvweqgvtvivmLtklvelgr.kcaqywpeegg.tygdftvtllkveh.ldgytvrtlevtn..ngesrtvthfqytgwp

DRGVPSSSRSLLDFRRKVNKCYRG--RSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGaKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAI
| |||.|...||.| ..|.....   ...|..||||.| ||.||.......|. . |. ...|.  ....|| ||||.||| .|..|   |..| .. .
dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqleke.ggvdvleavkelreqRpgavqtpsqyrflydallellkrk
subfamily_PTPRN_pd Subfamily PTPRN 715-1011 1.1e-178 587.2 In-house 1-297 (297) alignment 
Range on Protein: 715-1011
Range on HMM: 1-297/297.0
SEEPVQSNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNP
|||||.||.||||||..|||.|||||||.||||||||||||.|||... ||..|.|| |||| |||.|||||| ||.|.|...|||||||.|.|||||.|
seepvvsnldistGhvvlsyledhlknkdrlekewealcayeaepstkevakaeknvkknrskavlpydhsrvklkeeasaeksdyinasaildhdprap

AYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDR
|||||||||..|||||||||||.|.||||.||.|.|.||.||..|||||||..||||||.||||||||.|.||||||||||||.|||||||||||||...
ayiatqgplastvadfwqmvweqGvvvivnltrleeegvkqckrywpdeGsevyhiyevhlvsehiwcddylvrsfylknlqtsetrtvtqfhflswpee

GVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILK
|||.|..|||.|||||||.||||||||.|||||||||.|.|.|||.|||...||.||||||||||||||||||.|.||.||||||||||||||||||
gvPasaksllefrrkvnksyrGrscpivvhcsdGaGrtGvyilidlvlnrllkGvkeidiaatlehlrdqrpglvktkdqfefaltavaeevnailk
0045450 (Phosphotyrosine protein) phosphatases II 719-1004 8.1e-86 283.8 In-house 3-302 (307) alignment 
Range on Protein: 719-1004
Range on HMM: 3-302/307.0
VQSNMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAE-PNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSH-SHSDYINASPIMDHDP-----
.. .. |.. ...| .....|.....|.||.| |. .. . ...  .|...|| .|||.  .| |||.|| |. .... ..||||||| ......     
lplslfidalkllllvllllldfltgllkefekllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllldg

--RNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSN-LYHIYEVNLVSEHIwCEDFLVRSFYLKNL-QTNETRTVTQFH
  .. ..|||||||| ||.|||.|.|| |. ||||||.| |.| ..|..||||||.   |. . |.|.||.. .... || . ...| .|.|.||||.||
ydlkrkfIatqgPlpetvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfh

FLSWYDRGVPSSSRSLLDFRRKVNKCYRG--RSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKE--IDIAATLEHLRDQRPGMVQTKEQFEFALTAVA
...| | |||.|  .|||| ..|.|...   ...|..||||.| ||.||.......|  . |. .   .|.  ....||.||||.||. ||..|   |..
ytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall

E
|
e
0051299 (Phosphotyrosine protein) phosphatases II 722-1004 5.5e-94 310.1 In-house 2-284 (288) alignment 
Range on Protein: 722-1004
Range on HMM: 2-284/288.0
NMDISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAEpNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPImDHDPRNPAYIATQG
...||. ...  ... .......|..|.|.|.....  ..  .|...||..|||.  .| |||||| |. ......||||||| | |  ... ..|||||
dteisveellklvlkllangltglleefeellsllpd.ltlsaallpenleknRysdilpydhsRVkLsvldgvegsdYinAsyi.dgynlkrkfIatqg

PLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIwCEDFLVRSFYLKNL----QTNETRTVTQFHFLSWYDRGVP
||| ||.|||.|||| .. ||||||.| |.|...|..|||..||  |. . |.|.||.. ..|. || ....||    ...|.||||.||...| | |||
PlpntvedFWrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseev.lddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvp

SSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGaKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE
.| ..|||| |.|.|... ...|..||||.| ||.||....|..|. . |. ...|.  ....|| |||||||| ||..|   |..|
dspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqleke.ggvdvleavkrlreqRpgmvqtpeqyrfvyealle
0043336 (Phosphotyrosine protein) phosphatases II 725-1003 1.6e-85 282.2 In-house 2-274 (278) alignment 
Range on Protein: 725-1003
Range on HMM: 2-274/278.0
ISTGHMILSYMEDHLKNKNRLEKEWEALCAYQAepNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPImDHDPRNPAYIATQGPLP
||. ...  ..| .|..| .|..|.| |. ..   ..  .|...||..|||.  .| |||||| |. .... .||||||| . |  ......||||||||
isvkdllkallelllnlktllllefeellsfkl..dtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyv.dgynvprkfiatqgPlp

ATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPdEGSNLYHIYEVNLVSEHIwCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLL
 ||.|||.|||| |. .|||||.| |.|. .|..||| .||  |. . |.|..|.  ..|. || . ..||...|.||||..|.|.| | |||.|  .||
etvedFwrmvwelgvttivmLtelvelgrvkcaqYwp.ggsltygdftvtllkeeh.lddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslslll

DFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAkEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVA
|| ..|..... .. |..||||.| ||.||.......|. . |.  ..|.  ....|| ||||.||| .|..|   |..
dflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeg.gvdleeavkelreqRpgavqtpsqyrflyeall
subfamily_Ptp69D_pd Subfamily Ptp69D 727-1005 8.4e-70 230.3 In-house 6-285 (307) alignment 
Range on Protein: 727-1005
Range on HMM: 6-285/307.0
TGHMILSYMEDHLKNKNRLEKEWEALCAYqAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNpAYIATQGPLPAT
   .  ..   . . .  |.||.| | |    . |. |....||  |||. .. ..|. || ||  | . .||||||| |  .. ..  .|| |.|. ||
iddleealksrkrdtdfglakeyekLear.eidkstkvsekkenalknRyedikafDktRvkLkkingkedsdYinasfikgykekk.kfiaaqdPveat

VADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIwCEDFLVRSFYLKNLQ-----TNETRTVTQFHFLSWYDRGVPSSSR
. |||.|..|    .||||. | |   ..| .|||.|    |    |.||||.  ..|.  |.... . .      ...| |.|.|...| |  || ..|
igDfWRmiaeqevtlivmlsnlteknrkkcakYWpiedevqygdilvklvseek.hsdyiiReldvskkkeesgevedsrkvvqyhytgWkDskvPevar

SLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMaKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEE
.||.. ..|.. |.    ||.|||| |.||||..| .|..|... |  ...|| .|  .|| ||. .||  ||..|   |... 
gllklieqvrelyklnrsPivvhCsaGvgrsgifvaldsllqql.kaedkvdifetvkdLrsqRnllvqsleqYvflyralldy
subfamily_Urchin-PTPRA_pd Subfamily Urchin-PTPRA 727-1005 5.6e-64 211.5 In-house 18-290 (319) alignment 
Range on Protein: 727-1005
Range on HMM: 18-290/319.0
TGHMILSYMEDHLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNpAYIATQGPLPAT
. .. ||  .|  .....|| |. ..|   ..      |  ..|  |||   .|..|...| |.  .    ||||||| .  .  ..  |||.||||. |
ayyqqlsnksdfdddltklevefrracklgvnladqtfanldqnkdknriinilafdknvvklerliGeefsdyinasfvtGyqrkd.kyiaaqGPldnt

VADFWQMVWESGCVVIVMLTplaengVRQCYHYWPDEGSNLYHIYEVNLVSEHIwCEDFLVRSFYLKN-LQTNETRTVTQFHFLSWYDRGVPSSSRSLLD
.||||.|.||. |  ||.||        .|  ||| ..   .  ..|.. | .  .... ||.. | .  . .. | .|||||| | | ||| ..  |. 
ladfWrmiweyncstivllt......kdkcsqywplkivikeerfkvkvdsvee.taeyvvrdielsedgkekdirkitqfhflGwpdvGvpdypsdlmr

FRRKVNKCYR--GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMaKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEE
. .||..  .      .|.|||| |.||.|.|. .|..|..| |  | .|.  ... ||.||. .||   |. |  .|. ||
lvkkvrhltskenhranivvhcsaGvGrtGvyivldvlldrm.keekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
0040438 (Phosphotyrosine protein) phosphatases II 728-1006 8.9e-88 289.9 In-house 3-276 (317) alignment 
Range on Protein: 728-1006
Range on HMM: 3-276/317.0
GHMILSYMEDHLKNKNRLEKEWEALCAYQAEpnSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPImDHDPRNPAYIATQGPLPATV
 ...| ..  .......|..|.| |. .. .  .  ||...|| .|||.  .| |||||| |. .... .||||||| . |   .....|||||||| ||
ldlllalldllksdftalleefedllslkld..tysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyv.dgpnlkrkfIatqgPlpntv

ADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIwCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFR
.|||.|||| |. ||||||.| |.|...|..|||....  |. . |.|.||.  .... .| . ...|...|.||||.||...| | |||.| ..|||| 
edFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseee.lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfl

RKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAkEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV
..|.........|..||||.| ||.||.......|. . |.  ..|.  ....|| ||||.||| ||..|  .|..| .
eavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeg.gvdveeavkelreqRpgavqtpeqyrflydalleyl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 731-807 1.6e-07 25.0 In-house 7-84 (440) alignment 
Range on Protein: 731-807
Range on HMM: 7-84/440.0
ILSYMEDHLKNKNR---LEKEWEALCAYQAEPNSsfVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIM
|.. . |...|. |    | ||  | .  ..|.   .|   .|  |||   .|.||||||.|.  ..  .||||||| | 
ivadfadyvqnnrrsrafedewsllpsglsqpsd..iaslpnnkvknryrnilaydhsrvmleevkgvpdsdyinasyin
subfamily_Sponge-PTP8_pd Subfamily Sponge-PTP8 732-1008 3.7e-68 224.9 In-house 11-285 (305) alignment 
Range on Protein: 732-1008
Range on HMM: 11-285/305.0
LSYMEDHLKNKNRLEKEWEALCAYqaePNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDpRNPAYIATQGPLPATVADFW
   .|.. .... ||.....|.     ..| .| ..|.|. |||. .. ..|..|. |....|. .||||||| .  .. |. .||..||||. ||||||
ayikearvysdkgleaqykslyee...eesidvgkkeankaknrlkeitlldddriiltekeslddsdyinasyvdgyk.rkkkyivaqgPlkntvadfW

QMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSN--LYHIYEVNLVSEHIwCEDFLVRSFYLKN-LQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRR
....|   ..||||| | |.|  .|. |||.. ..   .  ..|.| ||.   .|.. | . . .  . .|.|||.|... .| | ||| .. |||.. .
rliveekvstivmltklveggkdkCrqYWpesktekkefgefsvelksekt.asdyieRklkisiededkesrtvlqyqltdWPdhGvpqfatsllslik

KVNKCYR-GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMaKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNA
.|.| .. ..  |..||||.| ||.|... .|. |... |  ...|..  | .|| .|..||||..|. |   |..|....
rvqkdqkkdkgvpllVhCsagvgRtGvfiavdialerl.kkEevvdvfevlkqlRskrmkmvqtldqYvflhdaldelitc
subfamily_PTPRB_pd Subfamily PTPRB 733-1003 1.7e-74 245.5 In-house 15-282 (293) alignment 
Range on Protein: 733-1003
Range on HMM: 15-282/293.0
SYMEDHLKNKNRLEKEWEALCAYQAEpNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNpAYIATQGPLPATVADFWQ
 ... . ... |. .|.| | | . . ..  .|....|  |||   .|.|||||| |.| ...|.||||||. | ..  ..  .|||||||| || |||.
hvkkmkadsdlrfseeyeelkavgkd.qavkaaelavnraknrytnilpydhsrvkLaalkdesgsDYinanyipgynspr.efiatqGPlpetvddfWr

MVWESGCVVIVMLTPLAENGVRQCYHYWPDE-GSNLYHIYEVNLVSEHIwCEDFLVRSFYLKNlqTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVN
||||. . .||||| | |.|  .| .|||..  . ||   .|.||.|.   ||. .|.. ...  ..|.|.|.|.||.|| | |||.....|||| |.|.
mvwekkssiivmltqlvekgkvkCeeYWPadeepvlyGdikvtlvaeee.ledwvirelkiek..ekeerkvrqyhftsWpdhgvPektktlldfvrtvr

KCY--RGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKgAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVA
.      .. ||.|||| | ||.||.. .|..|... .    .||.... .|| .|  .|||..|. |  ..| 
eaiektaskrPivvhCsaGvGRtGtfialdrllqaiee.edyvdifgivaelReeRnllvqtekqYifihqcvl
0047943 (Phosphotyrosine protein) phosphatases II 734-1004 4.2e-87 287.4 In-house 3-270 (273) alignment 
Range on Protein: 734-1004
Range on HMM: 3-270/273.0
YMEDHLKNKNRLEKEWEALCAYQAePNSSFVAQREENVPKNRSLAVLTYDHSRVLLkaenSHSHSDYINASPImDHDPRNPAYIATQGPLPATVADFWQM
.. ..|.....|..|.|.|. ..  . .  ||...||  |||.  .| |||||| |    ....||||||| . |  ......|||||||| ||.|||.|
lllekllgltllleefelllslkp.lltysvallpenkdknrykdilpydhsrvkl....gdggsdyinAsyv.dgynlkrkfiatqgPlpntvedfwrm

VWESGCVVIVMLTPLAENGVRQCYHYWPDEG---SNLYHIYEVNLVSEHIwCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKV
||| .. ||||||.| |.| ..|..|||.||   |  |. . |.|.||.. ..|. || ..|.||.|.|.||||.||...| | |||.|  |||.| ..|
vweqnvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseet.kddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielv

NKCYRG--RSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGaKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE
.|...   .. |..||||.| ||.||....|..|. . |. ...|.  .. .||.|||||||| ||..|   |..|
rkalealpsngpvvVHCsaGvgRtgtfialdllldqleke.ggvdvleavkllrsqRpgmvqtpeqyrflyealle
subfamily_Anemone-PTP-5_pd Subfamily Anemone-PTP-5 734-1008 1e-71 236.7 In-house 14-285 (319) alignment 
Range on Protein: 734-1008
Range on HMM: 14-285/319.0
YMEDHLKNKNRLEKEWEALCayQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNpAYIATQGPLPATVADFWQM
... . . .. ||||.. |   .|....   |..||| .|||   .|.||..|| |.. .    ||||||| |  .. |. ..||||.||  |. |||.|
lkalastgetllekefkllk..eavndtfdsaskeenkkknryqnilaydrtrvvlseldgvegsdyinasfidgyqere.kfiatqaPlentiedfWrm

VWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHiWCEDFLVRSFYLKNLQTN-ETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNK
||| .. ..|||| |.|..  .. .|||.|  . |  . |.| .|.   ||. .| . |...... |||.|..|....| | .|| ...||||. ....|
vWeeessivvmltklveklkvklkkywpeenfeeyGrlivtleeee.eledyiirklklnkkssevetRevkhfqyteWpdhdvPekatslldllkrirk

CYRG-RSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAkEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNA
  ..  | ||.||||.|.|| ||.. .|..|... . .  .|.  |  .|| ||. |||..||..|   |. | |.|
srektqsgPivvhCsaGvGRtGtfivldamlervkeeg.vlDvfstvsrlRtqRnimvqrpeqYkfiyealleavea
subfamily_ptpA1_pd Subfamily ptpA1 735-974 4.5e-36 119.5 In-house 13-265 (418) alignment 
Range on Protein: 735-974
Range on HMM: 13-265/418.0
MEDHLKNKNRLEKEWEALcAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNpaYIATQGPLPATVADFWQMV
...|.|   ....|.  |      |. .   ... |  |||   .|  .|.|| ||  . .  ||||||  |    |..  .|.|||||| |.||||.||
lknhikcihkikeefrll.eesvgpsetsegdkkhntsknrytnilpvnhtrvqlkkiqdkegsdyinanyidgaypkq..fictqgplpntiadfwrmv

WESGCVVIVMLTPLAENGVRQCYHYWPDE-----------GSNLYHIYEVNLVSEHIWCEdFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRS-
||  | .||||.  .||   .| .|||..           | ...  | |.||      |   . .  ..     ||| .||...  | |. .|  ..  
wenrcriivmlsresencrikcdrywpeqiggeqfsiygngnevfgtysvelveviqdpe.reiitrnirltfegetrditqyqyegwpdhnipdhtqpf

--LLD-FRRKVNK--CYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDI
  ||     . |.      |  ||||||| | ||.||..   ....|. .  |..| 
rqllhsitnrqnqiipssdrnvpiivhcsagvgrtgtfctavimmkkldhyfkqlda
0036941 (Phosphotyrosine protein) phosphatases II 736-1005 6.9e-85 280.2 In-house 6-276 (297) alignment 
Range on Protein: 736-1005
Range on HMM: 6-276/297.0
EDHLKNKNRLEKEWEALCAYQAePNSSFVAQREENVPKNRSLAVLTYDHSRVLLkaenSHSHSDYINASPImDHDPRNPAYIATQGPLPATVADFWQMVW
 ..|.....|.||.| |. ... . |  ||...||..|||.  .| |||.|| |    ....||||||| . |   .. ..|||||||| ||.|||.|||
lekllflalllkefeellplll.lgslsvallpenleknRykdilpydhtRVkl....ddegsdYinAsyv.dgydlkrkfIatqgPlpntvedFWrmvw

ESGCVVIVMLTPLAENGVRQCYHYWPDE--GSNLYHIYEVNLVSEHIW-CEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNK
| .. ||||||.| |.|  .|..|||.|  .|  |. . |.|.|.... ..|. .| . .......|.||||.||...| | |||.| .||||| ..|.|
eqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrk

CYRG--RSCPIIVHCSDGAGRSGTYVLIDMVLNKMAK--GAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEE
...   .. |..||||.| |||||....|..|. . .    ...||  .. .||.||||.||| ||..|   |..| 
vlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallel
subfamily_PTPN6_pd Subfamily PTPN6 736-1005 6e-73 240.5 In-house 19-296 (306) alignment 
Range on Protein: 736-1005
Range on HMM: 19-296/306.0
EDHLKNKNRLEKEWEALCAYQA-EPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKaENSHSHSDYINASPIM-DHDPRNPAYIATQGPLPATVADFWQM
|.. ..|. .|.|.|.|   .| .  |   ... ||  |||  ..| .||.|| || |.| . ||||||. |. .    . .|||||| |..||.|||.|
eeeslekagfeeefeelqqeeakkllsrkegakpenkeknryknilPfDhtrvilk.epsvpgsdyinanyikkevkgsdksyiatqgclettvsdFWrm

VWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNL-YHIYEVNLVSEhIWCEDFLVRSFYLK-NLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVN
||.  . ||||.|   | |  .|..||||| ..  |  ..|. |||    .|. .|.. .. . . .|.|.| |.|| || | |||..   .||| ..||
vwqensrvivmttkevErgkekCarYWPdeeekeeyGkisvtnvse.ksladYilRelsvskkkkkkeerevfqyhfksWPdhgvpkdpgavLdfledvn

KCYRGRS----CPIIVHCSDGAGRSGTYVLIDMVLNKMAKG--AKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEE
. ..  .     ||.||||.| || ||...||..|... |     .|||  . . .|.|| |.|||..|. |  .|... 
rkqeeleeaeagpivvhCsaGiGRtGtfiviDillkliekkgldadidiqklvksvreqrsglvqteqqykfvykaikky
subfamily_Sponge-PTP11_pd Subfamily Sponge-PTP11 736-1008 4.5e-64 211.1 In-house 13-285 (290) alignment 
Range on Protein: 736-1008
Range on HMM: 13-285/290.0
EDHLKNKNRLEKEWEALCAyQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSH--SHSDYINASPIMDHDPrNPAYIATQGPLPATVADFWQM
..| |.... ......| .  .....  |.  ..| ..||.  .. ||  |. |.  ..|     .||||. | ..   . .|||||||.. |..|||..
nghakgnegfrnqfkmlds.gesehtvtvgltssnkllnRfanivvyddnritLrpisghkDCtneyinAcyikgyke.kkqyiatqgpvsntlvdFWkl

VWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCeDFLVRSFYLKNLQT-NETRTVTQFHFLSWYDRG-VPSSSRSLLDFRRKVN
.|.  . .|||||   |.|  .|. ||||.... |  ....|..|..   ..  | . .|| .. .....|||... .| . | |.  . .|| ... ..
iwqekvtiivmltniieegkvkCqqYWpdsdtkaygefsikllneetln.eyierklevknknsagakqsvtqyqitnwdstgkvtnpqtillvieemyk

KCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMaKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNA
. ..    .|.|||||. |||.... ... .||. |    ||. . |...| |.||.|||..|...  . | . .. 
tqrkrgntsivvHCSdtvgrsavfcaaattinkc.ktegvidvfqvlksqRiqkpgsvqtvqqyqgifqivltylds
subfamily_Urchin-PTP-7_pd Subfamily Urchin-PTP-7 736-1004 1.2e-61 203.4 In-house 17-277 (315) alignment 
Range on Protein: 736-1004
Range on HMM: 17-277/315.0
EDHLKNKNRLEKEWEALCAYQAEPNSsfVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHdPRNPAYIATQGPLPATVADFWQMVW
. .   || .....|..   |  |    ||.. ||. |||   ...||.||| |   . ..||||.||. |  .  ..  |||.|||..|.| |||..|.
qkkastkngfkqdyesipggqlhpld..vakkienkqknryiniiaydksrvqlpllendphsdyvnanfidGy.nkkrryiaaqgpnvasvkdfwrlvf

ESGCVVIVMLTPLAENGVRQCYHYWPDEgSNLYHIYEVNLVSEHIWcEDFLVRSFylKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYR
|  .  ||||| |.|.  |.. .||||.   .|  . | ..|| .  ... ||..       .. |.| |.|. || | ||| .. .|... |.|..   
eedigkivmltnlvegekrkaekywpdk.kviyGkitvtrkseevn.teytvrtl..svvfgdnirevvqlhytswpdmgvpkytiplmnlirtvkqhht

GRSCPIIVHCSDGAGRSGTYVLIDMVLNKmAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE
   ..|.||||.| ||.||.. .| ||.. |.  . ||.   .. .|..| .|||. ||..|   |. |
nsvgaivvhcsaGvGrtGtfitldavldq.aeaenaidvynfitgvrqnrikmvqvaeqyqfiydalle
subfamily_Sponge-PTP10_pd Subfamily Sponge-PTP10 736-1008 2.5e-61 202.2 In-house 13-280 (287) alignment 
Range on Protein: 736-1008
Range on HMM: 13-280/287.0
EDHLKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKaensHSHSDYINASPIMDHDpRNPAYIATQGPLPATVADFWQMVW
..| |...  .. .  |   . ....  ..  ..| .|||.  .| .|  |||||      | |||||. |  .   . |.|....|.  |. .||....
kghakgnegfknqftvleqvtqredevthniasqnkdknRltqilvpdnyrvllk....gehpdyinavfidgyk.ekkafiiaesPmfntarnfWklid

ESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHiWCEDFLVRSFYLKNLQ-TNETRTVTQFHFLSWYDRG-VPSSSRSLLDFRRKVNKC
.    .||||. . ||  ..||.|||.| | ..  |...|..|.   .....| . .|| . ......|.|... .| ..| |..   .|| . ... . 
drnvtaivmlcqekendeevcyqyWpeeksvvlGeyniellnee.vnagyierklevknknkagdkqqvkqyqitnWdstgkvtepqtillvieemyktq

YRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKgAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNA
..    .|.|||||. |||.... ... .||  .    ||.   |.. | |.||.||| ||..|   .| | ...
rkrgntsivvhCsdtvGrsamfcaaattinkckt.eGviDvfqvlksqriqkpgsvqtveqykfindivleylds
subfamily_PTPN23_pd Subfamily PTPN23 736-1010 1.3e-60 199.7 In-house 8-284 (288) alignment 
Range on Protein: 736-1010
Range on HMM: 8-284/288.0
EDHLKNKNRLEKEWEALCAYQAEP-NSSFVAQREENVPKNRSLAVLTYDHSRVLLKaensHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMV
.  |..|  |.|... |  .|..  ..  .|  . .. ||||  .| |||.|| |.     |. |||||| . |  |  | .||||.||. |..|||.||
rkmldgktaldkkfkeleqkqdkearkrsiaiaklyseknrsrdilPyDhnRvklr....gskDDYinAsfvkdlspgcPdfiatqaPlqstlnDFWlmv

WESGCVVIVMLTPLAENGVRQCYHYWPDEG--SNLYHIYEVNLVSEHiWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNK
.|    |||||.  .| |  .. .||| .   .. .  ..| | |..   | .  | . |. |.......|.  .. || . |||.|  .||.|  .|..
yeqkssviVmllskeelgkpkvdrYwPedkgetvkfgdlsvtlksvr.etethvervlkletldadavksvshlqltsWpelGvPasPetllqfldeves

CYR----GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAIL
.|.        |..|||| | ||.|.. |.  ..... ||   .||   ...|| ||  |||.|||..|.. || |... .|
ayeavqrksktPlvvhCsaGvgRtgvfalvyaavrelekgnglldiiqvvsrlreqRrfmvqekeqlkfsyeavleaarrvl
subfamily_PTPRD_pd Subfamily PTPRD 738-1008 7.9e-93 307.0 In-house 18-283 (564) alignment 
Range on Protein: 738-1008
Range on HMM: 18-283/564.0
HLKNKNRLEKEWEALCAYqaEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDpRNPAYIATQGPLPATVADFWQMVWES
. ... ..|.|.. .     .  .  .|. ..| .|||   .. |||||| |.. . .. ||||||| |  .. .. |||||||||. |..|||.|||| 
kansdlkfeeeykkieeg..qqftweaankpaNkaKNRyanivaYdhsRVvLskvegdegsDYINAsfidgyr.krkayIAtqgPlaetiedFWRmvweq

GCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIwCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGR
 . .||||| | |.|  .| .|||..|.  |  ..|.|..|.   .|. .|.| ||. ...|.|.|.|||| || |.||| | .||||..|||... .  
nsstiVmltkleEkgkvkchkYWPekgtetygeltVtleeeee.ladyeirtfklkkkkssesreVrqFhFtsWPdhgvpesatslLdlirkvralnepd

SCPIIVHCSDGAGRSGTYVLIDMVLNKMAKgAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNA
. ||.|||| | ||.||.. ||..|... .  | .||  ....|| ||. ||||.||. |  .|..| ...
agPivVhCSaGVGRTGtfividamlerike.ektvDiyqyvkalrkqRnamVqteeQYiFiheailealac
subfamily_Choan-PTP-1_pd Subfamily Choan-PTP-1 738-1010 1.5e-72 239.1 In-house 9-280 (281) alignment 
Range on Protein: 738-1010
Range on HMM: 9-280/281.0
HLKNK-NRLEKEWEALCAYQAEpNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDpRNPAYIATQGPLPATVADFWQMVWE
. .|. . . .|.|.| | . . |..  ....||| |||   .  ||..|| .. .......|||||. .   .  . .|||||||.||....|||||||
lsqndnaGfieeyeklaaigvd.ntataskadenvlknrYsnivaYDatrvkvtpneenkntDYinanfvpgyk.gekeyiatqgPvPaslvafWqmvwe

SGCVVIVMLTPLAENGVRQCYHYWPDEGSN-LYHIYEVNLVSEHiWCEDFLVRSFYLkNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYR
    .|||.|   |.|  .|..||||. |.  |  . |. ..|.   . .. | | | . ...|||.|.|.....| | |||.... ||.||..|.|. .
qkvsaivmvtreieagklkChrYWPddnselkygdvtvkstaee.ekatyierkfkl.eresgetreveqlaytaWPdhGvPattkellefrkevlklte

GRS-CPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAIL
 .. .|...||| | ||.|||. .| ....... ..|.|. |....|| .|  ||||  |.||   || . ..  |
kktkaplvihCsaGvGrtGtyialDrlvkaveaeleeldvkavvaelrkernlmvqtvvqyefvykavldaldkel
subfamily_PTPRG_pd Subfamily PTPRG 738-1007 7.9e-68 224.0 In-house 14-288 (563) alignment 
Range on Protein: 738-1007
Range on HMM: 14-288/563.0
HLKNKNRLEKEWEALCAYQAEP-NSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHS-DYINASPIMDHDpRNPAYIATQGPLPATVADFWQMVW
| ... ....|.|||    ..       .|..||  ||| | ...||.||| |.    . .. |||||. |. .  .. |.|||||||. |. |||.|.|
hadgdigfseefealqsetiskdldaehsqkpenkrKnRylnivaydrsRvklsplpgkkkklDYinAnyidGyq.kskafiatqgplkdtfddFWrmiW

ESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWC----EDFLVRSFYLKNLQT-NETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKV
|    .|||.| | |.| |.|  ||| ..|  |   .|.|..|.. .    . . .. . ||. .  .. ..|.|.|. .| | |||..|   | | .| 
eqnvaiivmitnlvergrrkcdvYWPkdesetygalqvtlieeevlalytvrtlviknlklkkkkqcdteklvrqyhytkWPdhgvPehslpvLifvkks

NKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKgAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVN
..  .    ||.|||| |.||.|||. .| .|... .  . ...  .| |.| ||. .|||.||. |   |. | ..
saankaeaGPivvHcsaGvgrtGtyivldtllkqiqq.enavnvfgflkhiraqRnflvqteEqYiflhdalleaia
subfamily_Choan-PTP-3_pd Subfamily Choan-PTP-3 738-1003 3.3e-55 181.9 In-house 5-274 (287) alignment 
Range on Protein: 738-1003
Range on HMM: 5-274/287.0
HLKNKNRLEKEWEALCAYQAEPNSSFV-AQREENVPKNRSLAVLTYDHSRVLLKAENSHShSDYINASPIMDHDpRNPAYIATQGPLPATVADFWQMVWE
... |. ..|| .||.         |  |.   .| |||   || .|..|||| ||  .  ||||||  .  .  .. |.||.|||..||| |||..|.|
errvkddvdkevdalkedsesstatfkaaeelaavkknryadvlPiddtrvllsaegelG.sdyinanyvasyt.ddeafiaaqgPiaatvrdfwravle

SGCVVIVMLTPLAENGVRQCYHYWPDEGSN-LYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSS----SRSLLDFRRKVN
    .....|   |..  .||.|||.     .   | | |..  |   .. ||.. | .|.|.|.| | |...||| |.... .     |  || .....
trsasvitmtreveearlkcykywPerevPmrvGGysvvlldydikePeygvralrlidletrearvvkqldllswPdkvlaPtavglirfvldvkqhie

KCYRGR-SCPIIVHCSDGAGRSGTYvLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVA
    .    |..||.. |.||||.. |  .|| .. .   ..|.||.. .|| .| ..||.  |. .   |..
lardasevGPlvvhddvGiGrsGil.latlvlvsrledlGrvdvaavvirlreyraalvqavvqlrllyealv
subfamily_Sponge-PTP3_pd Subfamily Sponge-PTP3 738-821 5.5e-09 30.1 In-house 18-95 (95) alignment 
Range on Protein: 738-821
Range on HMM: 18-95/95.0
HLKNKNRLEKEWEALCAYQAEPNssFVAQREENVPKNRSLAVLTYDHSRVLLKAensHSHSDYINASpIMDHDPRNPAYIATQG
| .  . ...|. ..      |    |   | |.|||| | .. || .|| | .   .  ||||||  ..|   |. .|||.||
hsnsdqefdnefksismtsgapy..tvgsseanipknrflnifpydatrvvltt...krdsdyinac.fvdgyarkncyiaaqg
subfamily_Anemone-PTP-2_pd Subfamily Anemone-PTP-2 739-1007 6.7e-79 260.2 In-house 23-291 (298) alignment 
Range on Protein: 739-1007
Range on HMM: 23-291/298.0
LKNKNRLEKEWEALCAYQA--EPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNpAYIATQGPLPATVADFWQMVWE
 |.  ....|.. | . .   | ... ||...||  |||   ....|.|||.|..|..  .||||||| .  .. || |.||||.||..||.|||.||.|
kkkltgyalefqrlnsvsseieeeekevarkpenkkkNRyadiialdssRvvLekedadeesdYiNAsflhaykgrn.afiatqaPltetvedFWrmvte

SGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCeDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKcYRG
    .|||||.| | .  .. .||||||.. |   .|.| |..    |. || . ... .....|.| |.|| || |.|||. ..|.||..|||.. .. 
edigtiVmltnleeldktkyhkywPdegketygeitvsllskeefa.dlivrklkvskkkeekerevrqlhftsWpdkgvpenatsvldllrkvra.sqq

RSC--PIIVHCSDGAGRSGTYVLIDMVLNKMaKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVN
..   |.||.||.| |||||.. || ||... |  . .|.  ... || .|||.|||.||. |  .|| | ..
qagnkpvivqCsaGvgRsGtfiaidsvlerv.kkeqvvDvfqvvkvlRkkrpgavqteeqYvfiyeavleald
subfamily_Urchin-PTPRB-like_pd Subfamily Urchin-PTPRB-like 739-1003 4.1e-74 244.2 In-house 17-276 (288) alignment 
Range on Protein: 739-1003
Range on HMM: 17-276/288.0
LKNKNRLEKEWEALCAYQAEpNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPImDHDPRNPAYIATQGPLPATVADFWQMVWESG
 .|.. ...|...| | . . .|. .... .| .|||   .|.||. || ||  .  . .|||||| | | . .. .||||||||..|| |||..|.|  
arnrtgfseeynsLaalekt.ksvtagrlavnakknRyrnilpyDekrvklkkleeeagaDYinasyi.dgekkkkkyiatqgPladtvndfWelvyenk

CVVIVMLTPLAENGVRQCYHYWPDEGS-NLYHIYEVNLVSEHiWCEDFLVRSFYLKnlQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGR
   ||||| | |.| ..| .||||..  ..|   .| ||...   |||..|.. |.  .... ...||...|.| | ||| |.. ||...|.|.      
tstivmltelveggktkCeeYWPdadkpknyGsvtvtlvesk.eledfvlrkllle..kkkteleitqyqylaWpdhgvPeskapllellrqvkvanqad

SCPIIVHCSDGAGRSGTYVLIDMVLNKMAKgAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVA
. |||||||.| ||.||.. .|...... .  . ||.|.|...|| ||. .|||..|.||   ...
tgpiivhCsaGvGrtgtFialdalidavee.edyiDvagtvaklRkqRallvqtlkqYefiyevll
subfamily_PTPN9_pd Subfamily PTPN9 739-1004 4.8e-66 217.8 In-house 10-288 (297) alignment 
Range on Protein: 739-1004
Range on HMM: 10-288/297.0
LKN--KNRLEKEWEALCAYQAEPNSsFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASpIMDHDPRNPAYIATQGPLPATVADFWQMVWE
.|.  |. | ||.... . ..| .   ...   |. |||   || ||..|| |. .. ...||||||.  .|   .. |.|||||||. || |||.||||
vkekgkrGlskeyaeirnepveGtf.lasklranleknrytdvlcydetrvvlakvdedeasdyinan.fvdGykqkkafiatqGplkktvsdfWrmvWe

SGCVVIVMLTPLAENGVRQCYHYWP--DEGSNLYHIYEVNLVSEHIwCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKC-
. ..|||| | . |.| ..| .|||  .| |. .  ..|. |. .   ||. ||.. .|| .|.|.|.|| | |||| | |||||. ||||...|| .  
qevlvivmttrvvergrlkcgqyWpleeessaefgdlsvsnvevee.eedykvrvleiknvkteesrkvthfqflsWPdyGvPssaaslldvlekvrekq

------------YRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAkEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE
            .. .  ||.|||| | ||.||.. .|. |... . .  .|.  |...|| ||  ..|| ||.||   || |
alavkelgdewkghpsgPPivvhcsaGiGrtGtfitldiclsrleevg.tvdvvetvkllrtqrafsiqtpeqyefcylavle
subfamily_CG7180_pd Subfamily CG7180 739-1005 7.6e-51 167.5 In-house 11-289 (296) alignment 
Range on Protein: 739-1005
Range on HMM: 11-289/296.0
LKNKNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPImDHDPRNPAYIATQGPLPATVADFWQMVWESG
 ..| |.| . |   . . | .    . |.||  |||   |. ||. ||.|.  . ...||||||. . |   .. .|| |..|   || .||..|.. .
krrkfrveyklelkltprleigdCagglrkenreknrdvkvvPyDynRvvLekldGeeksdYinavyv.dsflkkkeyivteapkketvdefWrlvydee

CVVIVMLTPLAENGVrQCYHYWPDEGSNLYHIYEVNLVSEHIWCeDFLVRSFYLKNL----------QTNETRTVTQFHFLSWYD-RGVPSSSRSLLDFR
.  .|.||   .    ..  ||| .. . |   .|..|.|. .  ..  | | |.             . |||.|..|..  |.    ||.|. .|...|
isavvvLtktfdfak.mypsywpnkskeqygeifveiveekqya.nlkirtfkltkkivalteqekqvkaetRivklfqlteWeledkvPlstnalielr

RKVNKcYRGR------SCPIIVHCSDGAGRSGTYVLIDMVLNKMAKgAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEE
|.|.. .|..        |..|..||||.||| |. ||. |... |  .|.|.   .  || .||..|...|.. .    . | 
rrvrl.wrekvdedpeegPvvvvssdGasRsGvylaidanlelvek.eeevdvFeavktlrrsRpqLvenveeYkyiYdvllea
subfamily_Sponge-PTP6_pd Subfamily Sponge-PTP6 740-1006 4.5e-46 152.2 In-house 16-279 (439) alignment 
Range on Protein: 740-1006
Range on HMM: 16-279/439.0
KNKNRL-EKEWEALCAYQAE--PNSSFVAQrEENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDpRNPAYIATQGPLPATVADFWQMVWE
|||. . ....| . . . .   ..|..|| | . .|||   | ..||.|| |.      || ||||  |  .   .  |||||||   |. |||..|.|
knkqeifkeifekinstspdyaciaslaaq.eydqtknrykdvgafdhtrvtlqeipgvphshyinanyikGyy.ddklyiatqgpkkettddfwrlvie

SGCVVIVMLTPLAEngvrqCYHYWPDEGSNLYHIYEVNlVSEHIWCEDFLVRSFYLKN--LQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCY
  .| ||||| | |      |.||| ..   |    |  |   |   .. .| | . |   .|.  ||| |||...| |. ||. .  .||| | .| . 
kktvtivmltnlve.....sykywpsdaevcygdiavr.vdrnielpnyvirgfkvfnerdttekertvlqfhyiawpdknvpaqashvldflrainsan

RGRS-CPIIVHCSDGAGRSGTYVLIDMVLNKMaKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV
  .   |..|||| | ||.|| . .|. |... |  ...||   .. ||.||  |||.  |. |   || |..
dkeeygpvvvhcsagvGrtGtiialdialeql.klenkvdikgivkvlrkqrkqmvqalcqyvfiynavledi
subfamily_Sponge-PTP9_pd Subfamily Sponge-PTP9 740-1000 7.5e-41 134.8 In-house 12-287 (301) alignment 
Range on Protein: 740-1000
Range on HMM: 12-287/301.0
KNKNRLEKEWEALcaYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENS--HSHSDYINASPIMDHDpRNPAYIATQGPLPATVADFWQMVWES
|..|..|.....|  ...|..|. |  .||| . ||   . .||. |..|| ...   .. .||||| | .   .. ..||.|||.  |..|||...|. 
khsnkfeeqykel..kegedksctvglseenkalnrfknitvyddnriilkpkpnldlcqreyinasyidgys.ekkkfiaaqgpmkktlvdfWrliwqe

GCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEV-NLVSEHIWCEDFLVRSFYLK---------------NLQTNETRTVTQFHFLSWYDRGVPSSSR
  | |||.| | |.   .|..|||.   . .. ... ......    ||..|.. .|                 .......|.|..  .| . ||    |
kpvsivmvtnlkegtkskceqywpnseaeseefgpftvtlvneqvyPdfvirqlnvkiqdgsnngyierkfkvksdksswdvlqlqvtdWpqdGvvrepr

SLLDF-RRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKmAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALT
  |      . .  .    |..|||||. .|||.|. ... |   .|    .|.    . .| ..||.|.| ||. .   
tvLqviddvihrqqkigggpvvVHCSdtVsrsGvYcsvsiglEQ.ckaegVVdvfqvtkavrrskpgaVtTLeqytsiyd
subfamily_Anemone-PTP-6_pd Subfamily Anemone-PTP-6 742-1008 2.1e-78 258.6 In-house 19-282 (318) alignment 
Range on Protein: 742-1008
Range on HMM: 19-282/318.0
KNRLEKEWEALCAYQaEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPImDHDPRNPAYIATQGPLPATVADFWQMVWESGCVV
.  |..|.|.|   . |  .|. .  . |  |||   .|.|||.||.|.  ...  ||||||. | |   |. ||||.|.||| |. |||.|||| .. |
elllseeyerlsrse.etvtslkslepvnkaknryanilaydhtrvkLqmlegeegsDyinanyi.dGyrrkkayiaaqaPlpetieDfWrmvWeqnsav

IVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSeHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCY-RGRSCP
||||| . |.| ... .|||..||. |    |.| . .. ..|...|.| ... ...|.|.| |.|. || |.|||.|. ||||. |.|.|   .    |
ivmltqeeergkakvhryWPskgsrsygklvvelke.evelsdyvlrefkvtrteeeesrqvrqyhytsWpdegvpesgaslldlvrqvskaqqksgagp

IIVHCSDGAGRSGTYVLIDMVLNKMAKgAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNA
|.|||| | || |... .|..|.....  . .|.  | ..||.||. ||||..|.||  ... | ...
ivvhCsaGvGrtGvfiavdillerika.ealvDvfqtvkqlreqrnlmvqtedqyefiydvllealas
subfamily_PTPN13_pd Subfamily PTPN13 742-1004 6.4e-63 207.6 In-house 10-267 (273) alignment 
Range on Protein: 742-1004
Range on HMM: 10-267/273.0
KNRLEKEWEALCAYQAEPNSSfVAQREENVPKNRSLAVLTYDHSRVLLKAENShshsdYINASPIM-DHDPRNPAYIATQGPLPATVADFWQMVWESGCV
..  ..|.. |   ..  ... |....||  |||   || ||..|| |..| .     ||||| |    .  .  |||.||||| ||.||||||||  . 
qqqPaeefkelrelkpldtce.vgkkkenkdknryrnvlPydetrvklgdegg.....yinaslikvpvgkdeyeyiacqGPlPetvkdfwqmvweqkae

VIVMLTPLAENGVRQCYHYWPDEGSNLYHIYE---VNLVSeHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRgR
||.|.|   |.|  .|  |||.. ..   ...   |.|.      ..| ||.. .|.....|.| |....| .| | |||||. .|| | ..|..  .  
viamvtlekekgkvkchrywPesknkklkvsnrlevellk.vqkldgfvvralavkdsesgesrevahlnfvkwPdhgvPssaaellqfvaevrrlqt.d

SCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAkEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE
. ||.|||| | |||||.. ||.||. ...   |.|.  ....||.|| |.||||.|. |   |. |
agPivvhcsaGiGrsGtlitidvvlglierdk.efdvkeivrklreqrqgvvqtkdqyifvykaile
subfamily_PTPN14_pd Subfamily PTPN14 742-1003 1.8e-55 183.1 In-house 22-293 (300) alignment 
Range on Protein: 742-1003
Range on HMM: 22-293/300.0
KNRLEKEWEALCAYQAEPNsSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHsHSDYINASPIMD-HDPRNPAYIATQGPLPATVADFWQMVWESGCV
. .. .|.| .   ... .   .|. .||..|||   || |...|| |.. .   ...||||| |      ..  ||..||||. || ||||||||.|  
egkvfteyeripkkredal.lstaklpenaeknrfkdvlPyednrvelsptken.stgyinassikvsvggkersyivaqgPleltvqdfWqmvWeqgvq

VIVMLTPLAENGVRQCYHYWPDEGSNLYHI-YEVNLVSEHIW--CEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNK-----
.|||||   |.|  ....|.|...|.  .. ..   |...     . .  ... || | ..| |||  . .  | |.|||.  .. |.. ..|.      
livmlteeeedgkeksfkyfPkleskkktvefgkfkvttkfsedsdsvittglklkhlpskeertvwhlqytDWpdhgvPeDvkgflsyLeevqsvrrkt

--CY--RGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGaKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVA
      . .. |..||||.|.||.|  .| |.... . .. .||||  .|..|| ||  .|||  |..|  ... 
nseveskeskPPvlvhCsaGvGrtGvlilsdlliatlehn.eeidikkvlarLreqrmllvqtlaqYkfvYkvli
subfamily_Sponge-PTP1_pd Subfamily Sponge-PTP1 742-1011 6.2e-33 108.9 In-house 5-264 (267) alignment 
Range on Protein: 742-1011
Range on HMM: 5-264/267.0
KNRLEKEWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHshsdYINASPIMDHDPRNpAYIATQGPLPATVADFWQMVWESGCVV
.  .|||.| .     . .       |.|  .||   .| ||..|| |. ..      ||||| .  .  .| |.|.||.||  |..||.... . .. |
eceiekefelikkisdtsstisqsiaeknqernrlddnlpyddtrvilrtkeee....yinasyvegyktkn.afivtqdplkntitdfltvihdqkvpv

IVMLTPLAENGVRQCyhyWPDE-G-SNLYHIYEVNLVSEHiWCEDFLVRSFYLKnLQTNETRTVTQFHFLSWYDRGVPS-SSRSLLDFRRKvNKCYRGrS
||.||.  .. .|.    || . | .. |.   |.   |.   .|. . .. || .. . .. || ...  |          . |.    | |.   | .
ivlltkvftdnirlf...wPPkmgqakkyqdltvehslek.eendyqiitlelk.fknesahnvtlyyykkwnintnnkpylkplfgilak.nqleng.n

CPIIVHCSDGAGRSGTYVLIDMVLNKMaKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILK
 |..|.|||| |||||.. ||  |... |     ||   | ..|.||.|.|.|||.. .    .||  .  ||
rPlvvacsdGvGrsGtflvidsqlera.ktegvsdifdflrkirsqriglvdtkeryiyihellaeyaegrlk
subfamily_PTPRA_pd Subfamily PTPRA 743-1004 5.1e-73 240.8 In-house 32-293 (330) alignment 
Range on Protein: 743-1004
Range on HMM: 32-293/330.0
NRLEKEWEALCAYQAEPnSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNpAYIATQGPLPATVADFWQMVWESGCVVI
... .|..|| | . .  .  .|..|||  ||| . .| ||.||| |   . . .||||||| |  .  ..  .||.|||.  || |||.|.||     |
klfreefnalPagpiqa.tlelaskeenkeknrvvnilPydfsrvilsvkeGveesdyinasfidGykekd.kfiaaqGPkeetvedfwrmiweqksati

VMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNlVSEHIWCEDFLVRSFYLK----NLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRS
|||| | |    .|. ||||||.  |    |. | ..  ..|. || | ..    . . ...| |.|||| || | |||. .. .|.. .||.|. .  .
vmltelkerkeekcaqywPdeGlvtyGnirve.vedetvlvdytvrkflvqqlpdatrekksrlvrqfhftswPdvGvPfepiGmlkllkkvkklnqqsa

CPIIVHCSDGAGRSGTYVLIDMVLNKMaKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE
 ||.|||| |.||.||.. .| ||... |  . .|.  ....|| ||| ||||.||.||   .. |
gpivvhcsaGvGrtGtfivldavlerv.kaerkvdvfefvkrlrlqrpqmvqtdeqyefiykvlle
0046845 (Phosphotyrosine protein) phosphatases II 745-1009 4.1e-88 290.7 In-house 2-277 (284) alignment 
Range on Protein: 745-1009
Range on HMM: 2-277/284.0
LEKEWEALCAYQAEPN-SSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSH-SHSDYINASPIMDHD----PRNPAYIATQGPLPATVADFWQMVWESG
||.|.|.|. ..  .  |  ||...||. |||.  .| |||||| || .... ..||||||| .  .|     .....|||||||| ||.|||.|||| .
leeefeellsltvklllslsvallpenlsknRykdilpydhsRVklksldgdledsdYinAsyvdgydldltyikkkfIatqgPlpntvedFwrmvweqn

CVVIVMLTPLAENGVRQCYHYWPDEG-SNLYHIYEVNLVSEHIwCEDFLVRSFYLKNLQ-TNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYR-
. ||||||.| |||. .|..|||.|| .  |. . |.|.||.. ..|. || ..|.||. |.|.||||.||..|| |.|||.|...||.| |.|..... 
vrvIVmltelvengrekcaqYwplegevltygdftvtllseev.kddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellen

-GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAK--EIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAI
 ....||.||||.| ||.||....|..|. . |.    ..|.  .. .||.|||||||| ||..|   |..| .. .
lpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyrfvyealleylklk
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 745-933 1.5e-33 111.0 In-house 9-196 (297) alignment 
Range on Protein: 745-933
Range on HMM: 9-196/297.0
LEKEWEALCaYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAenSHSHSDYINASPIMD-HDPRNPAYIATQGPLPATVADFWQMVWESGCVVIV
||.| ..|   .|...|  .|.|.  . |||   .|..| .|| |.   . . .|||||  ..  ... .  || .|||| ||| |||..|.| .  |||
leaekdlll.deargesfssakrnsslrknryrdilatddtrvkllr..viterdyinadyvvfpdeeadlkyilaqGplsatvddfwtlvaeqdvrviv

MLTPLAENGVRQCYHYWPDEGSNLYHIyeVNLVSEHIW--CEDFL-VRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKC
|.. | |.|  .|. |||.   .  .    ..| |..    ..|  |    |. .  .|.| |.   |||| | ||||    |  |. .|  |
mvaklqedGrdkcapywpsvvqerlka..gdvvveflsstsdefdrviltelqliyrsesrvvrhvqflswpdhGvpsdledlvrfqaqvcsc
subfamily_Cele-PTP-4_pd Subfamily Cele-PTP-4 745-998 2.6e-13 44.1 In-house 28-277 (302) alignment 
Range on Protein: 745-998
Range on HMM: 28-277/302.0
LEKEWEALCAYQAEPNSsfVAQREENVPKNRSLAVLTYDHSRVLLKAEnshsHSDYINASPIMDHDPRnPAYIATQGPLPATV---ADFWQMVWESGCVV
..||.... . ... ..       .|. ||.|  |  .|. .| |.||      .|.||| .   . . .  | .| |   ..   ..||.||..  .| 
vkkefkkidtmkvdlek..Ckafkknlkknqsedvpildsnlvkleae....pdsyvnaskvevPelt.rsiilaQlpkvdsedsveeFWrmvfqekivs

IVMLTPLAENGVrQCYHYWPDEGSNlYHIYEVNLV-SEHIWCEDFLVRSFYLKNLQTN--ETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKV-NKCYRGR
.|.|    |       ...| .  . |. |.   |    .   .  .  ...  |  .  ..  ..  ..  | .  || .  .|     || .|   . 
vvilvgeeelkk.tlselfpkksgd.ykeygkmfvNnrkVekaeeektryviEvlPegcsnsvlanvyvltnWkqkkvpvkyaeliktaakvfakkikad

ScPIIVHCSDGAGRSGTYVLIDMVLNKMAKGaKEIDIAATLEHLRDQRPGMVQTKEQFEFA
. ....    |||| |. .   ....|. || ||  |. ... .| ||| .|.. .|. . 
e.ntvivSknGaGRagafltlavaveklqkg.kepnikeivksiRsqRpravdslkQyvsl
DSPc_SM00195 746-1006 5.6e-82 270.4 In-house 3-262 (263) alignment 
Range on Protein: 746-1006
Range on HMM: 3-262/263.0
EKEWEALCAYQAEPnSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHdPRNPAYIATQGPLPATVADFWQMVWESGCVVIVML
..| | | ... .  ..  |....|. |||.  .| |||.|| || |.....||||||. |  .  .. .||||||||| ||.|||.|||| .. .||||
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TPLAENGVRQCYHYWPDE--GSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIV
|   ||| ..|..|||.|  |.. .. ..|.||....  ... .| . |.. ...|||.|||... .| |.|||.| .|.|.. |.|.|...  | ||.|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSDGAGRSGTYVLIDMVLNKMAKGAKeIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV
|||.| ||.||.|.||..|.|.... | .|| .....||.||||||||.||. |. .|..| .
hCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
PTPc_SM00194 746-1006 5.6e-82 270.4 In-house 3-262 (263) alignment 
Range on Protein: 746-1006
Range on HMM: 3-262/263.0
EKEWEALCAYQAEPnSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHdPRNPAYIATQGPLPATVADFWQMVWESGCVVIVML
..| | | ... .  ..  |....|. |||.  .| |||.|| || |.....||||||. |  .  .. .||||||||| ||.|||.|||| .. .||||
keefekleestspk.etteaekkknksknRyknilpydhtrVklkkeekkegsdYINAnyikga.nkkkkyIatQgPlpstvedFWrmvweekvkiivml

TPLAENGVRQCYHYWPDE--GSNLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIV
|   ||| ..|..|||.|  |.. .. ..|.||....  ... .| . |.. ...|||.|||... .| |.|||.| .|.|.. |.|.|...  | ||.|
teeeengkekcdrywpeesggketfgkisvklvevekkkdeiilrtleltkegkeetrkvtqyqyknWpdhgvpdstksvlellravkkskstssgpivV

HCSDGAGRSGTYVLIDMVLNKMAKGAKeIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV
|||.| ||.||.|.||..|.|.... | .|| .....||.||||||||.||. |. .|..| .
hCsaGvgRtgtfvtidiilskleeekk.vdifeivkelRkqRpgmvqtleqYlfiyeaileyi
subfamily_Cele-PTP-6_pd Subfamily Cele-PTP-6 746-996 9.6e-34 111.8 In-house 19-267 (307) alignment 
Range on Protein: 746-996
Range on HMM: 19-267/307.0
EKEWEALCayQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENShsHSDYINASPImDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVML
  |.. |.  . .|..  |   . |  |||   |   |..|...| .     |||| |  .     .   .|..|||| .|. .|| |. .     ..||
vdefrvla..kktpegvtveafsantdknryqdvkcqdkgrivvkfdgl..asdyihanyl.giaikpkkficaqgplentqysfwamaiqekvesviml

TPLAENGVRQCYHYWPDE-GSNLY------HIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVnkcyRGRS
  . | .  .|  ||| | | .|        |   || ....  .. |.    ||   ....||.... .  | |||||    . ...   |    |.  
ckvielakikceqywpleegqklvfgeapntisvanlgakklapdedlinvttlkvdwaqksrtiqhlqwenwpdrgvpqinltainlleav....rydt

CPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFE
 |..|||| | ||||| | | .| .|| .|    |.   .| ||.||.  .||. |. 
npvvvhcsaGvGrsGtivaislvqdkmiaGinckdmkklveelrsqrhyaiqteaqyl
subfamily_PTPN1_pd Subfamily PTPN1 747-1010 1.8e-64 212.3 In-house 6-275 (290) alignment 
Range on Protein: 747-1010
Range on HMM: 6-275/290.0
KEWEALCAY---QAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENShshsDYINASpIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIV
. .....     .|.  .  .|...|| ..||   |  |||||. |. ..     |||||| ... .  .  || |||||| ||. |||||||  .  .|
rlykeiyldirkeasdfptreaklpenrnlnryrdvspydhsrikleradn....dyinas.lveleeakrsyiltqGPlpntvdhfWqmvWeqkskavv

MLTPLAENGVRQCYHYWPDEGS--NLYH---IYEVNLVSEHIwCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNK--CYRG
||  . |..  .|..||| . .  .|      ..|.|.||..  . . || . |.||.|.|||....||...| | |||.|  ..|.|  || .  .   
mlnkvvekeqikcaqywPqgeeekellledtklkvkliseer.ksyytvrllelenlktqetreilhfhyttwpdfgvpespaaflkflfkvresGslss

RSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAK--EIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAIL
   | ..||| | |||||..|.| .| .. |  .   .||  .| .|| .| |..||..|..|. .|. | .. | 
dvGpavihcsaGiGrsGtfclvdtclvliekkddlssvdikkvllelrkyrlGliqtadqlrfsylaileGakvik
subfamily_Cele-PTP-14_pd Subfamily Cele-PTP-14 747-996 3e-25 83.4 In-house 31-280 (310) alignment 
Range on Protein: 747-996
Range on HMM: 31-280/310.0
KEWEALCAYQaEPNSSFVAQrEENVPKNRSLAVLTYDHSRVLLKAENSHsHSDYINASPIMDHDPRNpAYIATQGPLPATVADFWQMVWESGCVVIVMLT
|..  | | | ..  .. |  .... |||   |.  | ||| || ..|  . ||| |  .     |. ..| .||||  |. |||.|...  .  |..| 
kqyrkldakq.dssltyeay.kkymhknrysdvvcldtsrvklkidksr.yedyihanyvktnylrs.tficsqgplqhtiidfwrmifqeraesilllc

PLAENGVRQCYHYWPDEGS-NLYHIYEVNLVSEHiwCEDF----LVRSFYLKNLQTNET------RTVTQFHFLSWYDRGVPSSSRSLLDFRrKVNKCyr
  .|.|  .|  |||  |  . |    |  .||    |.|    |  .|   |.  .|         |.  ..  | |||||      .  |  . .   
kvgeegrpkcvgywpslgvtetygcirvtnlses..seefeicnlavtfvpdnvpvdeqpanlkelrvslikwpnwpdrgvpdekchtvpqr.llaqv..

gRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKeIDIAATLEHLRDQRPGMVQTKEQFE
 |  | .|||| | .| .. | ... ..|. .| | .|.     .|. .|   .||. |. 
.rhgpcvvhcsagkdrlyvvvalklkidkldrglk.vdaeevktellksraiciqtelqyl
subfamily_Urchin-PTP-8_pd Subfamily Urchin-PTP-8 748-1005 4.4e-61 201.8 In-house 3-254 (284) alignment 
Range on Protein: 748-1005
Range on HMM: 3-254/284.0
EWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNpAYIATQGPLPATVADFWQMVWESGCVVIVMLTp
|. ..|   ..      |  ..|  |||   .|..|...| |.       ||||||| |  .  ..  ||||||||. |.||||.|.||. |  ||.|| 
efrracklgvngtdqtfanldqnkdknrighilafdknvvklerliGeefsdyinasfitGyqrkd.kyiatqGPldntladfWrmiweyncstivllt.

laengVRQCYHYWPDEGSNLYHIYEVNLVSEHIwCEDFLVRSFYLKN-LQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYR--GRSCPIIVH
       .|  ||| ..   .. ..|.. | .  .|.. ||.. | .  . .. |...||||| | | ||| ..  |. . .||..  .      .|.||
.....kdkcsqywplkivikeerfkvkvdsvee.seeyvvrdielsedgkekdirkirqfhflgwpdvgvpdypsdlmrlvkkvrhltskenhranivvh

CSDGAGRSGTYVLIDMVLNKMAKgAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEE
|| |.||.|.|. .|..|..| .  | .|.  ... ||.||. .||   |. |  .|. ||
csagvgrtgvyivldvlldrmke.ekqvdvynfvrdlrqqrntlvqdlvqykfiysallee
subfamily_Urchin-PTP-5_pd Subfamily Urchin-PTP-5 748-1006 7.1e-59 194.3 In-house 29-284 (297) alignment 
Range on Protein: 748-1006
Range on HMM: 29-284/297.0
EWEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPrnpAYIATQGPLPATVADFWQMVWESGCVVIVMLTP
. | ||  .|.  .. ||..  | .|.|   .| || ||| |.  |..  |||.||| .         .|.|| | .|||||||.||..    .||||. 
seeflclpeaniqpqtvaekkvnfeksRYkniLPydssRvkLaivnddpdsDyvnasfvkgnkh...rlittqmPmkatvadfWamvldeqvstivmlnd

LAENGVrQCYHYWPDEGSNLYHIYEVNLVSEHiWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPS--SSRSLLDFRRKVNKCYRGRSC-PIIVH
. |.   .| .||.|.|.. .    | | | .  .| |. |.. ... ..  .| | |..|..| |. |.   | .|||..   |.| . ...  |..||
dnerdk.kcaryWsdkgvttfGdvsvvllsvs.ereGfikrelevtkgkakarrvvkqyqfveWPdkaverkdsassllklisevrkdfsqnaegPllvh

CSDGAGRSGTYVLIDMVLNKmAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV
|. | || | .. || |. . ||  ||.||  ....||..|| .||||||..|   || | .
claGvGrtgvlltidsvvae.akrekevdifglvkklrqerpylvqtkeqykfvyvavleal
subfamily_Sponge-PTP5_pd Subfamily Sponge-PTP5 749-1005 3.7e-50 165.4 In-house 12-265 (283) alignment 
Range on Protein: 749-1005
Range on HMM: 12-265/283.0
WEALCAYQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENShshsDYINASPIM--DHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLT
 | |      . .. .|  .|| .|||   ....|  || ||.|.     |||||. |.  ... ..  ||..|.||  || |||.||..   . |||||
revlkrlsvpdldadiasadenkrknrnqeivpadqwrvelksesr....dyinavfipvsksykqdkkyiiaqsPldrtvvdfWkmvfdekitaivmlt

PLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEhIWCEDFLVRSFYLKNL-QTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHC
.| |.   .|  ||| .||  |  . | |  |    . | .. . |..   ...|  .. . .  | . |  .   ||. | . . .  . .  ||.|||
klqedlrikCsqyWPkrGsedyGeftvtlrke.ttsnsfiikelllrvnssakstlllahyqvidWleygeqaiinslvkfnkvislqteskkgPivvhC

SDGAGRSGTYVLIDMVLNKMaKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEE
| | ||..... .   .... .    .|. |... .| ||...|||..|. .  ..| |.
stgiGrtavfiaasasvkda.ltesvvdvfavvkimreqrmmavqtldqyklvhelvleq
subfamily_PTPRK_pd Subfamily PTPRK 755-1004 1.9e-71 235.5 In-house 28-275 (314) alignment 
Range on Protein: 755-1004
Range on HMM: 28-275/314.0
YQAEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASpIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVR
|.. ..   .|...||  ||||  .|.||.||| |.. .  ..||||||. ..|   |  |.|.|||||. ||.|||..|.. .|  ||||| | |.|  
yeslfegwdaakkdenreknrsgdilaydrsrvflitidgdpssdyinaa.lidsykrpaafivtqgPlqetvkdfWrlvydencasivmltelvevgrv

QCYHYWPDEGSNlYHIYEVNLVSEHIWcEDFLVRSFYLKN--LQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRS
.|..|||....  |   .|.||. ..  ....|| | ...   . .|.|.| ||.||.| | .|| | ..||.. |.|.|    .  .|.|||| ||||.
kClkyWPedtev.ygdikvelvetell.aelvvrifrveklargqeeirevrqfqflgWpdhdvPvsatgllklvrrvkksqeeeaGrivvhCsaGaGrt

GTYVLIDMVLNkMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE
||.. ||.||. |..  . .|.  .   ||.... ||.|.||. |   .. |
Gtfiaidivld.mieregvvdvfnavktlrsrkvnmveteeqykfiydvile
subfamily_PTPN12_pd Subfamily PTPN12 755-1013 3e-71 234.7 In-house 24-284 (290) alignment 
Range on Protein: 755-1013
Range on HMM: 24-284/290.0
YQAEP-NSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDpRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGV
|.||   |. ....|||| |||   .| ||.||| |. .... .||||||. |   .  . .|||.|||||.|. |||.|.||    ..||.  . |.| 
ykaekvysteagekeenvkknrykDilPydksrvelskieeeegsdYinanfikgve.gkleyiaaqgPLpktlddfWrmiweknveivvmaCrevelgk

RQCYHYWPDEG-SNL-YHIYEVNLVSEHIWCEDFLVRSFYLKNLqtNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGR
 .| .|||.|| ..| .  .||.| .|.   .|||.|.. ...   .|.|.|.|||. .| |.|||||  |||.. ..|..  .  . |..|||| | ||
kkCerYWpeegeeelefgefevtleeekavdddflirtLkveaq..kesrkvyqfhYtaWPDhgvPssaksllelielvrelqesedaPlvvhCsaGvGr

SGTYVLIDMVLNKMAKGAK--EIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNAILKAL
 || . ||.| . . ..    |.|.   . .|| ||. .||||||.|.   |||| |.. |...
tGtiiaidyvrellkaekipeeldvfdlvlelrkqraalvqtkeqyelvykavaelvqkeleii
subfamily_PTPN3_pd Subfamily PTPN3 755-1003 3e-66 218.2 In-house 25-272 (280) alignment 
Range on Protein: 755-1003
Range on HMM: 25-272/280.0
YQAEPNSS-FVAQREENVPKNRSLAVLTYDHSRVLLKAENShshsDYINASPI-MDHDPRNP--AYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAE
|. .|. .  .|.. ||..|||   .|.||. || ||....    |||||. . |. .  .    ||||||||. |..||||||||  . .||||| | |
yrkkpglaisaarkpenlsknryrdilpydatrvklkeset....dyinanyvnmeipstglvnryiatqGPlaktatdfWqmvweqksslivmlttlve

NGVRQCYHYWPDEGSNL-YHIYEVNLVSEhIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGA
.|  .|..|||... .| |  ..|.. .|    . ...| ..||. .|.| |...|. .|.| | |||..| ..|.| ..|.|. .|.. |..|||| | 
rGrvkChqyWPetedeleygefsvkceke.detksyvlrelvlkdketkeerkilqlqylaWpdhgvPddsadflefvervrklrsgkeePvvvhCsaGi

GRSGTYVLIDMVLNkMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVA
||.| ..|... |  .   |... . . . ..||||  .|||..|..|   |. 
grtGvlilletala.lieaaepvypldivrtmrdqramlvqtasqykfvCeail
0049772 (Phosphotyrosine protein) phosphatases II 756-1009 3.4e-42 140.6 In-house 32-283 (314) alignment 
Range on Protein: 756-1009
Range on HMM: 32-283/314.0
QAEPNSSFVAQREENVPKNRSLAVLTYDhSRVLLKAENSHShSDYINASPIMDHdprnPAYIATQGPLPATVADF----------WQMV--WESGCVVIV
.  ...  ||. ..|  |||.| .| .| .|| |. .. .. ||||||| .  .     ..|||||||. || ||          |.||  ..  . .||
vlpeltilvadlflnrdknryldilpad.nrvilpglpvsg.sdyinasyvdgf....lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdiv

M---------------------LTPLAENGvrqcyHYWPDEGSNLYHiyevnlvSEHIWCEDFlvrsfylknlqtneTRTVTQFHFLSWYDRGVPsSSRS
|                     |..| .||      ... .   |..       .|. . |.|              .|.. ... . ..| ..| ... 
msrdevladelsrLdaAlgKtpllildgng.....neptaadlellk.......eelydpelf..............erlgikylripvpDgsap.lled

LLDFRRKVNKCyrGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMakgakEIDIAATLEHLRDQRP-----GMVQTKEQFEFALTAVAEEVNAI
...| . ....   .  |..|||..| ||.||.|...... ..      .... .||..| .||     |.... ||.|| | |. | .. .
fdeflefieea..dkggpvlvHCkaGkgRtgtfvvaaylmkll.....gvsleealedvrlkRpinpnpgfieqleqyefilealleylkfl
subfamily_Urchin-PTP-3_pd Subfamily Urchin-PTP-3 757-1006 1.5e-56 186.9 In-house 35-288 (325) alignment 
Range on Protein: 757-1006
Range on HMM: 35-288/325.0
AEPNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDhDPRNPAYIATQGPLPATVADFWQMV--WEsgCVVIVMLTPLaENGVR
 .. .  || . ||. |||   |...|.||| |.. .  ..||||||| . | | .   ..|.| ||.||. |.|..|  |.  | |.|.|  | ..|  
ddgiakkvamkpenkaknrfknvvaldksrvvletkkddpssdyinasylrd.dkkkdvflaaqaPltatindlWrlvldWr..csvvvvlnel.dlgkd

QCYHYWPDE--GSNLYHIYEVNLVSEHIWcEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRR---KVNKCYRG---RSCPIIVHCS
.|  |||.|   |  .   ||.|..      |.. | . .|. .  |||.| ||.. || | ||.    .|. . .   .|... .     | ||.||||
rcavywpkemgksktfGglevklrtieei.sdyvhrvldvkqvkkGetrsvkqfqlqswddmGvqkrpatlisilqlvkavservtantkastpilvhcs

DGAGRSGTYVLIDMVLNKMAKGAkEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV
.| ||.|... .  .|.|. . . ..||   ...|| .|| ||.| .|. .  .|..| .
aGvGrtGvfislysalakviees.rvdifgfvkklrkdrpsmvetvdqyiliyealveay
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 757-848 8.8e-13 42.5 In-house 25-120 (347) alignment 
Range on Protein: 757-848
Range on HMM: 25-120/347.0
AEPNSSFvAQREENVPKNRSLAVLTYDHSRVLLKAENSHS-----HSDYINASPIMdHDPRNPAYIATQGPLPATVADFWQMVWESGCV-VIVMLTPL
. .. .. .. | .. ||||  |   | .||.|  |.|.         ||||| |   |  .  || || ||| || |||.||       |. .. | 
spskfts.vewekslsknrskdvklidatrvvlspeksknsraddvetyinashik.fdnaskeyiltqyplpdtvrdfwkmvsvtkvtqvvtifepi
subfamily_Cele-PTP-15_pd Subfamily Cele-PTP-15 758-1002 1.8e-27 91.0 In-house 24-266 (285) alignment 
Range on Protein: 758-1002
Range on HMM: 24-266/285.0
EPNSSFVAQrEENVPKNRSLAVLTYDHSRVLLKAensHsHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCY
 || .. |  | |   ||   |   . .||.||    |   ||| || .      . .||.|||||| |..|||.|...     ..||  | | || .| 
ppnctytay.eanpdlnryadvrcieetrvvlkn...h.drdyihaswmrmpgkdqstyittqgplpetlsdfwhmiyqekiayvlmlctlfeggvekca

HYWPDEGSNL--YHIYEVNLVSEH-IWCEDFLVRSFYLKNLQT--NETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCyRGRSCPIIVHCSDGAGRS
 |.|..  ..  .  ||. |   .       .. .. . | .   .|   . . .   | |.  |  .| .... . |.|    .  || |||| | ||.
lyypeklgevvkfgkyeitlteckeeaiagtilnaltvintedasseplymnhvqvpwwpdqlapedarpmielykwvkkv.npkekpicvhcsagvgrt

GTYVLIDMVLNKMAKgAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAV
 |.| ||    .. .   .|..   .  .|  |   ||.. || |    .
atfvgidyatirime.npniemldivremramrfqavqshmqflflyvvl
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 758-893 1.6e-26 87.9 In-house 35-183 (350) alignment 
Range on Protein: 758-893
Range on HMM: 35-183/350.0
EPNSSFVAQREENVPKNRSLAVLTYDHSRVLLK--------AENSHSHSDYINASPIMDH---DPRNPAY--IATQGPLPATVADFWQMVWESGCVVIVM
. |   ...  |   |||   .| |.|||| ||         . |.| .|||||. .         || .  ||||.||| || ||.... . .  ||..
psnDvilseGvelfaknrYknilPYehsrvkLkkslkssdakkhslstnDYinanYlkltrfsveinpdfkYiatqaPlpstvddfykvillnkvkvils

LTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCEDFLVRSFYLK
||.. |.....||.||.. . . ...   .   . .  .|   .|. .|
ltsdvelnlekcyrYWqegsydditvklaskwenimgindsslysadvk
0045098 (Phosphotyrosine protein) phosphatases II 759-1006 2.6e-76 251.9 In-house 22-272 (278) alignment 
Range on Protein: 759-1006
Range on HMM: 22-272/278.0
PNSSFVAQREENVPKNRSLAVLTYDHSRVLlkaenshshsDYINASPIMDHdprNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYH
|.. ..|....|..|||   .| ||||||           |||||| |. .   ....|||||||| ||||||.|.|| |. ||||||.| |.|.  |..
pseitpalylgnldknRykdilpydhsrVk..........dYINAsyidgy...pkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaq

YWPDEGSNLYHIYEVNLVSEHIWcEDFLVRSFYLKNL----QTNETRTVTQFHFLSWYDRGVPSSS--RSLLDFRRKVNKCYR-------------GRSC
|||..||  |. ..|.|.||... .|. .| ... ||    ...|.|.||..|.|.| | ||||..  .|.|.. . ......             ....
ywpeggsltygdftvtllseevl.ddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsgg

PIIVHCSDGAGRSGTYVLIDMVLNKMakGaKEIDIAATLEHLRDQRPG-MVQTKEQFEFALTAVAEEV
|..|||| | ||.||.|.....|  .  . . .|.  ....|| |||| .||..||..|   ...| .
pvlVHCsaGvgRtGtlvaaylmlell..e.ggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_Urchin-PTP-1_pd Subfamily Urchin-PTP-1 759-1006 1.7e-60 199.5 In-house 33-277 (315) alignment 
Range on Protein: 759-1006
Range on HMM: 33-277/315.0
PNSSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDpRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYH
.    ||. ..| .|||   .| .|..|| |.  . . .||||||| |   |  . ||||.||||.|.| |||.||...    |||.| . |.   .|  
iyrqrvaretinfkknryknilPldsarvkleviddsPdsdyinasyiksvd.ddkayiasqgPlkasvddfwrmvlqekvttivmvtkkqegdkikcrq

YWPD--EGSNLYHIYEVNLVSEHiWCEDFLVRSFYLKNlqTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYV
||||    |  .  ..|.|.| .  . |  .| . ...  ..|.||||||.|  | |.||.  . ||| . ..|    . .  ...|||| |.||.|  .
ywPdrkadsvefGsikvellsle.adtdgvarklvtrk..seesrtvtqfqftewPdkGvdkqtssllklikevkadngkkefsllvhcsaGvGrtGvvi

LIDMVLNKMAKgAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV
 || |...... .. .|.  ... ||..|| .|||.|.. |   || |..
sidevvaqikr.trsvdvfnfvknlrakrpylvqteeeyafiydavledl
subfamily_eak_pd Subfamily eak 760-919 5e-17 56.3 In-house 42-197 (332) alignment 
Range on Protein: 760-919
Range on HMM: 42-197/332.0
NSSFVAQREENVPKNrSLAVLTYDHSRVLLKAENsHSHSDYINASpIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHY
 |  ...| |.| .|  . .. ||.  | | .     .  ||||| ...       || |  .    |  ||||| |     ||.|    |... .   |
lsisetarleavnrn.vvkivpydrylvrltssq.lnrlGyinas.laefsevGrkyiltGiasedkvfafwqmvleqkspaivqlledvelkleksdky

WPDEG--SNLYHIYEVNLvSEHIWCEDFLVRSFYLKnlQTNETRTVTQFHFLSWYDRGVPSS
.||..     . |..|.   |..  . . .| . |.  . |||  |  ...  | .  .|  
fpdktreelkfGildver.kefvkrniletrllels..kGnethrvlhykvfGwtettlpky
subfamily_Urchin-PTP-4_pd Subfamily Urchin-PTP-4 761-1006 8.4e-50 164.3 In-house 36-236 (392) alignment 
Range on Protein: 761-1006
Range on HMM: 36-236/392.0
SSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPrNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGvrqcyhyw
   |||.| |..|||   .| || .|| |.  .  ..|||.||| |   |  . ||||.||| .|.. |||.||..     |.|.| | |          
pqtvaqkeinlkknryknilpydsarvkleviddipdsdylnasyipsfdn.ekayiasqgpnaaslddfwrmvfqenvttiamvtklkegd........

pdegsnlyhiyevnlvsehiwcedflvrsfylknlQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDM
                                   . ...|||.||||  | |..||  . ||| | ..|.  .   . |.|.||| | ||.|  . || 
...................................kgddartvaqfhftewPdkdvpkhtssllkfikevkadfGqythpliihcsagvgrtgvvisids

VLNKmAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV
|. . || .. .|.   .  .| .|| |||||||. |   || |..
vvah.akktrmvdvfnfvtnirrkrpymvqtkeqyafiygavledl
subfamily_Sponge-PTP-2_pd Subfamily Sponge-PTP-2 761-863 7.5e-07 22.2 In-house 18-87 (169) alignment 
Range on Protein: 761-863
Range on HMM: 18-87/169.0
SSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINAspimdhdprnpayiatqgplpatvadfwQMVWESGCVVIVMLTPLAEngvrqCYHYW
  |.|.   |  |||  . |.  | || |.    .  ||||||                            .|.||.   |||.|    .        .|
nnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlgdtdd.....knnfw

PDE
|. 
pek
subfamily_Sponge-PTP2_pd Subfamily Sponge-PTP2 761-863 1e-06 21.7 In-house 17-86 (169) alignment 
Range on Protein: 761-863
Range on HMM: 17-86/169.0
SSFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINAspimdhdprnpayiatqgplpatvadfwQMVWESGCVVIVMLTPLAEngvrqCYHYW
  |.|.   |  |||  . |.  | || |.    .  ||||||                            .|.||.   |||.|    .        .|
nnfmaeltcnetknrpagplapshtrvklqrvmedlgsdyina............................rmiwetnasvivvlGdtdd.....knnfw

PDE
|. 
pek
subfamily_Urchin-PTP-6_pd Subfamily Urchin-PTP-6 762-1006 7.8e-63 207.3 In-house 35-276 (515) alignment 
Range on Protein: 762-1006
Range on HMM: 35-276/515.0
SFVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPrNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWP
  ||| | | .|||   .| || .|| |.  |   ||||.||| |   |  . ||||.|||..|.| |||..|..     |.|.| | |.   .| .|||
qtvaqeeinfkknryknilPydsvrvklevindnPhsdyfnasyipsfdn.dkayiasqgPnkasvddfWrlvlqenvttiamvtklkegdkikcgkyWP

D--EGSNLYHIYEVNLVSEHIwCEDFLVRSfyLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLID
|    |  .  ..|.||| .  | . . |   |. |. ...||||||||  | |.|||  ..||| . ..|       . |.|.||| |.|| | .. ||
dkpgdsvkfGsikvelvslea.ctggikrk..ltvlkgddsrtvtqfhfteWPdkGvpkhtssllklikevkadhgqythpliihcsaGvGrtGvvisid

MVLNKMaKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV
 |. .. | .. .|.  ... .|..|| .|||.||. |   || |..
svvaha.kttrmvdvfnfvtnirqkrpylvqtqeqyafiygavledl
0040439 (Phosphotyrosine protein) phosphatases II 763-1004 1.1e-75 249.7 In-house 4-244 (249) alignment 
Range on Protein: 763-1004
Range on HMM: 4-244/249.0
FVAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPImDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPD
 ||...||..|||.  .| |||||| |.  ... .||||||| | |   .....|||||||| ||.|||.|.|| |. ||||||.| |.|  .|..|||.
svallpenkdknrypdilpydhsrvklsilpglflsdyinAsyi.dgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywpl

EGSNLYHIYEVNLVSEHIwCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRG--RSCPIIVHCSDGAGRSGTYVLIDM
.||  |. . |.|.|... ..|. || ..|.||...|.|||.......| | |||.|  .|||| ..|.|...   ...|..||||.| ||.||......
ggsleygdftvtllsvev.kddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaayl

VLNKMAKGaKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE
.|. . |  ...|.  ....||.||||.||. ||..| . |..|
mleqleke.lgvdleeavkllrsqRpgavqnpeqyrflyealle
0037934 (Phosphotyrosine protein) phosphatases II 763-1003 8.8e-70 230.3 In-house 3-239 (243) alignment 
Range on Protein: 763-1003
Range on HMM: 3-239/243.0
FVAQREENVPKNRSLAVLTYDHSRVLLkaenshSHSDYINASPIMDHdPRnpaYIATQGPLPATVAD----FWQMVWESGCVVIVMLTPLAENGVRQCYH
..|...||..|||   .|.|||||| |      . ||||||. |.   ||   .|||||||| ||.|    ||.|.|| |. ||||||.| |.|. .|..
siallpenlsknrysdilpydhsrvkl......egsdyinanliyvt.pr...liatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaq

YWPdeGSNLYHIYEVNLVSEHIwCEDFLVRSFYLKNLQ-TNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKC--------YRGRSCPIIVHCSDGA
|||  |.  |. ..|.|.||.  ..|. || ..|.||. ...||.|...|.|.| | |||.|  .|||| ..|...        .. .. |..|||| | 
ywp..gevtygdftvtllseeh.lddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGv

GRSGTYVLIDMVLNKMakgakEIDIAATLEHLRDQRPG-MVQTKEQFEFALTAVA
||.||.......| ..     ..|.  ....||.|||| .||| .|..|   |..
gRtGtliaaylmllll.....gvdleeavkllreqRpgkavqtpsqyrflyeall
subfamily_Cele-PTP-10_pd Subfamily Cele-PTP-10 763-997 4.2e-28 92.9 In-house 46-280 (305) alignment 
Range on Protein: 763-997
Range on HMM: 46-280/305.0
FVAQRE--ENVPKNRSLAVLTYDHSRVLLKAENshsHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYW
| |..    .. |||   |   |.| |.|.  .    |||| |  .      .  .|..||||  |. .|| || .     ||||    | |  .| .||
fnanqsadiaitknryqdvpcqdqsavkldkps...psdyihanyvgcpmipekrficaqgpldqtidefwwmviqnkveqivmlcktvelgklkcaqyw

PDEGSNLYHIYeVNLVSEHIWCEDFLVRSF----YLKNLQ--TNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVnkcyRGRSCPIIVHCSDGAGRSGT
|    .  ..    .| | .     . |       | ||    ... .| ....  | |||||    . |..   .    ||   ||.|||| | ||.||
paaqgeklelk.sgivvenvsgskpmerdaeiqitllnltysgdqkmsvrhlqwtewpdrgvppckltslellsai....rgskvpivvhcsagigrtgt

YVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEF
 | |. .|.|.|.  .   .   .  |||||   .|.  |. |
ivaieyilekiaenkpcppmpelvkalrdqrafsiqndvqylf
subfamily_Nvec-PTP-2_pd Subfamily Nvec-PTP-2 764-1007 2.5e-70 231.6 In-house 3-243 (250) alignment 
Range on Protein: 764-1007
Range on HMM: 3-243/250.0
VAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRnPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRqCYHYWPDE
||.. .|  |||   ....|.|||.|. |..  .||||||| .  .| |  |.|||||||.||. |||.||.|    .||||| | |..   . .||| |
vakkpqnkeknryadiialdssrvvLekekgdkesdyinasflhgyder.kafiatqgPlqatiedfWrmvleeksgtivmLtnLkesekt.yhqywPve

GSNLYHIYEVNLVSEHIWCeDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRG-RSCPIIVHCSDGAGRSGTYVLIDMVL
... |    |.| |....  |. .| . | . . .. |.| |.||..| |.|||   .. |....||..  .   . |.||.|| | ||||... || ||
kaekyGdvtvsllskeefa.dytkrklklskakkaderivrqlhfvvWPdkgvPevatavLellkkvqasqqqagnaPvivqCsaGvgrsGafiaidavl

NKmAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVN
.. .|  | .|.   .. || .||..|...||. |  ... . ..
er.lkkekvvdvfkvikvlrkdrphavesleqyvfvyeiilkald
subfamily_Choan-PTP-2_pd Subfamily Choan-PTP-2 764-1008 3.4e-52 172.1 In-house 14-266 (270) alignment 
Range on Protein: 764-1008
Range on HMM: 14-266/270.0
VAQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDE
. .   .   ||.  .|   ..|| |. ... |.. ||||  .   | .. .|||..||||.|. .||.|.||.    |||.|.| |.| ..|  ||| |
lpeaargkklnRyadiLPsPatRvrleeleedsataYinAnyvrGfdgekkkYiaamgPlpttlksfwrmiweekvtaivmttgleEkgrkkCerYWpae

GSN--LYHIYEVNLVSEHIWC-EDFLVRSFYLKnlQTNETRTVTQFHFLSWYDRGVPSSSR------SLLDFRRKV----NKCYRGRscPIIVHCSDGAG
  .   ..  ... ....    | ....   |.  .. |.| .. |.. .| |.|||...       .||   |.|    ..  ..   |..||||.| |
pkekvkledgkikvlalseekeegyiltrlrle..ekgeerrlvHfwyntWpdhgvpreedsslstdqllkmlravrrsekeldkae..PllvHcsaGvg

RSGTYVLIDMVLNKMAKgAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNA
|.|| ...|.... . .  |..|..| .|.|| .|. .||. ||.||.  ||.| .. 
RtGtlialDiavrlLee.tkkvdvlaiieelRkdRmalvqhpeqyeflykavveyaer
subfamily_Cele-PTP-16_pd Subfamily Cele-PTP-16 764-1006 5.3e-17 56.4 In-house 41-279 (303) alignment 
Range on Protein: 764-1006
Range on HMM: 41-279/303.0
VAQREENVPKNRSLAVLTYDHSRVLLkaenshSHSDYINASpIMDHDPRNPAyIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDE
  |  .|. |||   |.  |||.| |      | | || ||  .. | .. | | || ||. | ||||||. |    ....|   .|         .| .
knqfvknmdknrfvdvicldhskvkl......sdssyihas.yleldsskka.iltqlplshtaadfwqmiieqkvkcvlllltdseydklggdsvfprn

GSNLYHIYEVNLVSEHIWCEdfLVRSFYLKNLQTNET--RT-VTQFHFLSWYDRGVPSS-SRSLLDFRRKVNKCYRG--RSCPIIVHCSDGAGRSGTYVL
   |     .  | |    |  |.  . || |   .   .. .   |. .|    .||  |  ..    ...   |    | | .     | ||.||. |
qdflkfeersirvgefkrve..lgdgwvlkvlsvsngdyksflhvhhykawphnsipsdgspkfvkqiwqlqsvlrkysdstptvymslsgcgragtfal

IDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV
..     . .    .|.   || .|. |   ||   || .  | .|| |
fetahlslhseqasldlvkclenvrngrlhavqnlsqfsvvytllaehv
subfamily_Sponge-PTP4_pd Subfamily Sponge-PTP4 764-864 3.8e-11 37.1 In-house 90-182 (244) alignment 
Range on Protein: 764-864
Range on HMM: 90-182/244.0
VAQREENVPKNRSLAVLTYDHSRVLLKAEnShSHSDYINASPImDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGvrqcyHYWPDE
 |   .|  |||  | | .| .|| |    |     ||||| .     |   || || ||  |  |||.|. |    |.|.|  . |.       |||| 
dafnpnnswknregaglpfdfnrvplskg.s.mgntyinasfv.gclgrtaeyiltqhpladtsmdfwkmmlerhvnvlvvlgsveeed.....eywpds

G
 
e
0042113 (Phosphotyrosine protein) phosphatases II 765-1003 4.1e-76 250.9 In-house 4-240 (245) alignment 
Range on Protein: 765-1003
Range on HMM: 4-240/245.0
AQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPImDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG
|...||..|||.  .| |||.|| |. .... .|||||||.. | . ..| .|||||||| ||.|||.|.|| |. .|||||.. |.|  .|..|||...
allpenkdknrysdilpydhtrvklspdggdldsdyinasyv.dgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplge

SNLYHIYEVNLVSEHIwCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYR-GRSCPIIVHCSDGAGRSGTYVLIDMVLN
|  |. . |.|.||.. ..|. || . ..||...|.|.|...|.|.| | |||.....|||| . |.|... ... |..||||.| ||.||.......|.
sltygdftvtllseeh.lddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmle

KMAKGaKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVA
 . |  .....  ....||.||||.||| .|..|   |..
qleke.lgvsleeavkelrsqRpgavqtpsqyrflyeall
subfamily_Nvec-PTP-1_pd Subfamily Nvec-PTP-1 765-1004 2.9e-59 195.1 In-house 2-238 (239) alignment 
Range on Protein: 765-1004
Range on HMM: 2-238/239.0
AQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG
|..  |  |||   ..|||||||.|.  .   |||||||| . |.|    ||||||| . ..  |||.|.|.   .|||||| | |   ..|..||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

SNlYHIYEVNLVSEHIWCeDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNK
|. |    | |    ... |...|.| . ..   | | | |.||  | |.|||  . ..| .|||. |     . | ..||| | ||.|....|| .| .
sk.ycnlrvtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

mAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE
 ||  | .||   .. .|..|| |||| ||. |   || |
.akkqktvdifnyvkairedrphmvqtseqyvfihlavle
subfamily_Anemone-PTP-1_pd Subfamily Anemone-PTP-1 765-1003 3.8e-59 194.7 In-house 3-238 (239) alignment 
Range on Protein: 765-1003
Range on HMM: 3-238/239.0
AQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG
|..  |  |||   ..|||||||.|.  .   |||||||| . |.|    ||||||| . ..  |||.|.|.   .|||||| | |   ..|..||||  
akkrvnkaknryanivtydhsrvvleklsndphsdyinasylrdydgspkayiatqgcveissgdfwrmmwqerrcvivmltglieghkkkchqywpdst

SNlYHIYEVNLVSEHIWCeDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNK
|. |    | |    ... |...|.| . ..   | | | |.||  | |.|||  . ..| .|||. |     . | ..||| | ||.|....|| .| .
sk.ycnlrvtlrktevfa.dyiirtfvmsqvgqteeryvyqyhftvwpdkgvpqyatavlglrrkitkdslpgarpwvihcsagvgrtgaflvidamlrq

mAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVA
 ||  | .||   .. .|..|| |||| ||. |   || 
.akkqktvdifnyvkairedrphmvqtseqyvfihlavl
subfamily_Cele-PTP-20_pd Subfamily Cele-PTP-20 765-997 2e-35 116.8 In-house 51-274 (290) alignment 
Range on Protein: 765-997
Range on HMM: 51-274/290.0
AQREENVPKNRSLAVLTYDHSRVLLKAEnshSHSDYINASPIMDhdpRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG
 ... .. |||   |   | .||.||      . ||. |  .      .. .| |||.| .|| |.|.|| . .  .||||  | |.|  .| .|.|.. 
fdkntefkknrykdvvcndktrvilkdG...ydGdyvhanyvkG...lkamfiltqGalkdtvidiwrmvlqekvaaivmlceliedGkakceqyypeke

SNLYHIYEVNLVS--EHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVnkcyRGRSCPIIVHCSDGAGRSGTYVLIDMVL
 .   . |. ..   |.   ..   . . ... ..     .  ..  || |. |. |. .||   | .    |  | |..|||| | ||.||.| |.. |
GevltfGeitvlcseeddkdaniikktlsvrdkdsGkehklkhlkikswpdksvalstlallrtlril....rkasGpvvvhcsaGiGrtGtfvaievgl

NKMAKGaKEIDIAATLEHLRDQRPGMVQTKEQFEF
. . .| ||.|.. .   ||. | . ||   |.  
qilldG.keldlldlvralrnsrlnsvqvdiqyla
subfamily_egg_pd Subfamily egg 765-1002 2.7e-24 80.4 In-house 35-266 (307) alignment 
Range on Protein: 765-1002
Range on HMM: 35-266/307.0
AQREENVPKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMdHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENgvRQCYHYWPDEG
|  ..|  | ||  |   | ||| |. ..     |.| |  .   .|    .| .| ||  || |||.||..  .  |||||   |.   .| .|||   
aasdnnlekarskrvhckdssrvklelrrGqylddfihanrvk.Gkpllnefilaqaplkntvddfwrmvfqeevqyivmltsrkes..erceyywpkae

SNLYHIYEVNLVSEHIWC---EDFLVRSFYLKNLQTNetrtvTQFHFLSWYDRGVPSSSRSLLDFRrkVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMV
|.   .   .|  | .      | | |   || . ..      .  ||  .   |  ||     .|  | .  |  | |..|.. .|  ...| | |.. 
sdslvtvpGslrienlkvdskadplfrvtklklvGgd.....deerflehwqgdvnnssdvysplr..vlrklrnlskpvvvqdilGvskaatlvaieia

LNKMAKGA-KEIDIAATLEHLRDQRPGMVQTKEQFEFALTAV
| .. .|      .  .   || .|.  |..  .. |    |
llsllrGpitkslvlravvflrlrrrlsvesvllylfvyrlv
subfamily_Cele-PTP-13_pd Subfamily Cele-PTP-13 766-996 6.3e-32 105.3 In-house 33-259 (281) alignment 
Range on Protein: 766-996
Range on HMM: 33-259/281.0
QREENVPKNRSLAVLTYDHSRVLLKA-ENSHSHSDYINASPIMDHDpRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEG
..  |  ||| | .   | ||| ||     .  .||| |  |      .  || ||||   | ||||.|.|.     ||||  . |    .|  |.| . 
nqpvnnkknrylnipcldisrvqlkvkmpnknstdyihanyirspf.lkrgyiltqgpkketradfwrmiwqenttaivmlcqfletnrekcaeyfprna

SNLYHIYEVNLVSEHIWCEDFLVRSfYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVnkcyRGRSCPIIVHCSDGAGRSGTYVLIDMVLNK
    .. .. .  |    .  || .  |.     ||| .|.. .  | |  || ||  .|   ||.    | || | ..||| | ||||| . ... |. 
hcclqfdklsvsyedstvnkslvtt.rlnlsyegetrlithwlwkewpdwqvpessevmlkilrki....rarstppvihcsagvgrsgtlmaveialqs

MAKGAKEIDIAATLEHLRD-QRPGMVQTKEQFE
.       ||   . |||   |   ||| .|. 
ihshftlpdikqivshlrvtgraasvqtlqqym
subfamily_Cele-PTP-8_pd Subfamily Cele-PTP-8 768-1006 1.2e-28 95.0 In-house 41-271 (288) alignment 
Range on Protein: 768-1006
Range on HMM: 41-271/288.0
EENVPKNRSLAVLTYDHSRVLLKaenshSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNL
 .|  ..|   .   | .|| |.       .|.  |. ..   . .   | .| || .|.  .|.|. ||.   ||||. | | | ..  .|.| .  . 
ianptrdryenlprcditrvkls.....ddpdfyiaanvvssakykrrlicaqaPlngtieelWkmllesdveyivmlcellekGkeksaeyfPsklGek

YHIYE-VNLVSEHIWCEDFLVRSFYLKNLQTNETRT-VTQFHFLSWYDRGVPSSSRSLLDFRRKVnkcyRGRSCPIIVHCSDGAGRSGTYVLIDMVLnKM
 .|    . | ..    | ||.   |.. .. |..  | . |.| | | ||| .  | | .   .    .    ||.||.| |.||.|| .|| ..| ..
arigrlctvvkkkradidklvkvsllriskegeekvivkilhlleWdddgvPenylsplrllevl....kslqkPivvhssaGvGrtgtlililial.es

AKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV
..    . |   |..||..|   .||. |. ..   | ||.
lrlddflgirsllaklreerfkaiqtemqylyvhrcvleel
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 768-871 2.4e-15 50.7 In-house 46-164 (349) alignment 
Range on Protein: 768-871
Range on HMM: 46-164/349.0
EENVPKNRSLAVLTYDHSRVLLKA--------ENSHSHS------DYINASPIM-DHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENG
 |   |||   .| |.|||| ||         ..|.|.|      |||||  .   .   .  ||||| |||.|| ||....   |  ... |.   |..
velfaknrykdilPyehsrvklkkslksskvikastsesdsgklddyinanylkltrisvekkyiatqaPlPstvddfykvillngvklvlsLnddkels

VRQCYHYWPDEGSNLYHIY
...|. || .   . ... 
lekcdiywqelsysnitvk
subfamily_Anemone-PTP-4_pd Subfamily Anemone-PTP-4 769-1000 3.8e-58 191.5 In-house 2-233 (237) alignment 
Range on Protein: 769-1000
Range on HMM: 2-233/237.0
ENVPKNRSLAVLTYDHSRVLLKAENSHshSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDE-GSNL
||  |||   . .||||||.||   |   ||||||. . . |     |||.|||| ..  |||||||.  | |||||| | |.   .|..|||.    . 
enkiknrygnivaydhsrvvlkgagsg..sdyinatylkgfdgtpkkyiaaqgplesscddfwqmvwqekcsvivmltgliegnelkchkywpstdqpaa

YHIYEVNLVSEHIWcEDFLVRSFYL-KNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKV-NKCYR-GRSCPIIVHCSDGAGRSGTYVLIDMVLnK
| .. | |  .  .  |. |||. | |.|. .| | . |..| || |||||  . .|| ||... |.     .|.| |.||| | ||.| ...|| .| .
ygvltvslkkkeef.sdytvrslllskrltlkevrlihqyqftswpdrgvpqqtaallrfrkniinrsphvsesgpwiihcsagvgrtgiflvidaml.r

MAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALT
 ||  | .||   .  . ..|| ..|||.|. |   
qakekkvvdiynyvysieedrpyiiqtkdqyvfihq
subfamily_Cele-PTP-18_pd Subfamily Cele-PTP-18 769-998 1.6e-30 100.9 In-house 47-279 (305) alignment 
Range on Protein: 769-998
Range on HMM: 47-279/305.0
ENVPKNRSLAVLTYDHSRVLLKAENSHshsDYINASPIMdhDPRNP-AYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNL
..  |||   |   |. || |..   |   .|| |  .    | ||  .| || ||  | |||| | ..     | ||  | | | ..|..|.. .  . 
qeagknrykdvgcldnnrvklegpwph...eyihanyvs..tptnpkrfictqaplektcadfwymclqdkveaifmlcnllekgakkcleyfaskdkdv

YHIYEVNLvSEHIWCEDFLV------------RSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVnkcyRGRSCPIIVHCSDGAGRSGTY
 .. | .     . .|                ..  . .   ...| ||..|.  | |||||..  ..|..  |     |    ||.|||| | ||.|. 
lefeekgq.kisvkfessvtlkfrkdakakvtetvlviegpgekarkvthyhwidwpdrgvpaadlailelleka....rpskgpivvhcsagigrtgsv

VLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFA
|... .|...  | .  |    | ..|.||   .|| .|. | 
vmleyildqllagqiiedtdkilqkireqrnnsiqtdaqylfv
subfamily_Cele-PTP-12_pd Subfamily Cele-PTP-12 769-869 4.7e-06 20.3 In-house 33-131 (332) alignment 
Range on Protein: 769-869
Range on HMM: 33-131/332.0
ENVPKNRSLAVLTYDHSRVLLKAENshSHSDYINASPImDHDPRNPAYIATQGPLPA-TVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNL
.|.  ||   .  .||||| |  ..   . |. ||| . |   .. ||| .| |.   |   ||.|| |    .|...  . |.  |.. .   | | . 
nnmdmnriphlycfdhsrvelapqd..gkddfynaswv.dgyskksayifaqapfndhteyvfwrmvserkpsmilvfgdidekqkrkapydisdrgfek

YH
  
sf
Y_phosphatase Protein-tyrosine phosphatase 770-1004 3.7e-77 254.3 Pfam-A 1-235 (235) alignment 
Range on Protein: 770-1004
Range on HMM: 1-235/235.0
NVPKNRSLAVLTYDHSRVLLkaENSHSHSDYINASPIMDHDpRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWP--DEGSNL
|  |||.  .| ||..|| |  ..| ..||||||. .. .. .. ..|||||||. |..|||.|||.  . |||||| | |.| ..| .|||  .|.|. 
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YHIYEVNLV-SEHIWCEDFLVRSFYLKNLQTN-ETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKM
|. ..|.|. .|. ..... .| . ||. ... |.|.|.|.|. .| |.|||.|..||||. |||.|  . .| |..||||.|.||.||.|..|..|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

AKGAKeIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE
 .. . .|.  ....|| |||||||. ||..|   |..|
eaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
Y_phosphatase Protein-tyrosine phosphatase 770-1004 3.7e-77 254.3 In-house 1-235 (235) alignment 
Range on Protein: 770-1004
Range on HMM: 1-235/235.0
NVPKNRSLAVLTYDHSRVLLkaENSHSHSDYINASPIMDHDpRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWP--DEGSNL
|  |||.  .| ||..|| |  ..| ..||||||. .. .. .. ..|||||||. |..|||.|||.  . |||||| | |.| ..| .|||  .|.|. 
nkkknRykdilpydktrvkl..kgsegpsdYInAnyvkgyk.ekkkfIatQgPlkstiedFWrmvwqekvkvivmltsleekgrekcaqYwpeeeeeslt

YHIYEVNLV-SEHIWCEDFLVRSFYLKNLQTN-ETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKM
|. ..|.|. .|. ..... .| . ||. ... |.|.|.|.|. .| |.|||.|..||||. |||.|  . .| |..||||.|.||.||.|..|..|...
ygdikvelkekekedekeytlrklelkkkkeesekrevkqlhytnWpdhgvpespkslldlirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleql

AKGAKeIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE
 .. . .|.  ....|| |||||||. ||..|   |..|
eaeee.vdvlqivkelRkqRpgmvqsleqYiflykaile
subfamily_PTPN5_RR_pd Subfamily PTPN5_RR 770-1006 2e-58 192.7 In-house 28-268 (274) alignment 
Range on Protein: 770-1006
Range on HMM: 28-268/274.0
NVPKNRSLAVLTYDHSRVLLKAENSHSH-SDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSN--
.  |||  ..|  ..|||||..|.|... |.||||  |   | .. ||.||||||| ||||||.|...  . |||||| | |.  ..| .|.||. .   
sqtknryktilPnensrvllesessededssyinanyikGydeeskayvatqGPlpntvadfWrmiyqeevqvivmltklkeaneqkCavyfPdaedyei

--LYHIYEVNlVSEHIWCEDFLVRSFYLKNLQTneTRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGR---SCPIIVHCSDGAGRSGTYVLIDMV
   |   |.. |.. . ..|. ||...||.|.   .|.|. . . .| |. .| . ..|||. ..|..  . .     |..|||| | || | .. |.. 
serygdveik.vekiverndysvrklvlkyler..ersvkhywytdWPdhksPddantlldlvleveesreeenaklapvvvhCsaGiGrtGcfiaisia

LNKMAKgAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV
.... .  . .|.  .  .|| .| |||||.||.|.   |... .
vrqlre.eivvdvlkivcnlrldrGGmvqtseqyelihralclyl
0041856 (Phosphotyrosine protein) phosphatases II 770-1005 1e-45 150.9 In-house 1-170 (182) alignment 
Range on Protein: 770-1005
Range on HMM: 1-170/182.0
NVPKNRSLAVLTYDHSRvllkaenshsHSDYINASPIMDHDPRNPaYIATQGPLPATVADFWQMVWESGCVVIVMLTplaengvrqCYHYWPdegsnlyh
|..|||   .| |||||          ..|||||. ..   | .  .|||||||. |||||..|..| |. .||.||         ...|||        
nldknrysdilpydhsr..........dldyInanlylgslpatr.fiatqgpllstvadflrmlkelgittivnlt.........eelywp........

iyevnlvsehiwcedflvrsfylknlqTNETRTVTQFHFLSWYDRGVPSsSRSLLDFRRKVNKcyrgRSCPIIVHCSDGAGRSGTYVLIDMVLNKmakga
                           ....|...|...|.| | |||.  ..|||| ..|..    ...|..|||| | ||.||.|...... .     
...........................ellerlgiqylylpwpDhgvpd.ldelldfieevle....eggpvlVHCsaGvgRtgtlvaaylmkkl.....

kEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEE
 ....  .....| .|||||.| .|. |   |. |.
.gvsleeavklvrsrRpgmvitpnqyfflqlallel
subfamily_CG42327_pd Subfamily CG42327 772-926 8.8e-26 85.3 In-house 30-186 (319) alignment 
Range on Protein: 772-926
Range on HMM: 30-186/319.0
PKNRSLAVLTYDHSRVLLKAENSHSHSDYINASPIMDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPD----EGSNL
.|.| . |.   ..|| |.   .. .. |..|| .  .|  .  |||.| .|  . .|||..|||    ||| || | |.|...| .|.|     .. .|
dksrvinvvPlPetrvvlqrigdddkdeyldasyvrGyddapnsyiaaqvsledsssdfwrtvweqqsrvivqltdlselGikvcaeylPtketldntsl

YHIYEVNLVSEHIwCEDFLVRSFYLKNLQTNETRTVTQFHFlSWYDRGVPSSSRSLLDF
|  . | |    .  . ... .. ||... .|.| .| . .  | . .||.. ..|.  
yGdilvtlkgrev.kdryaistlllkrvdkeesrelthywy.kwleaevPaeeaaliam
subfamily_Cele-PTP-11_pd Subfamily Cele-PTP-11 774-1005 2.5e-18 60.8 In-house 47-275 (312) alignment 
Range on Protein: 774-1005
Range on HMM: 47-275/312.0
NRSLAVLTYDHSRVLLK-AENSHSHSDYINASpimDhdpRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGS-------
||   .  .|  |  |   || . |.....         .   ...|||||  |.. |||..   |.. |..|. . |.|  .| .|  |  .       
nrypniqcwdrgrftlagdenfyihanfvkic...t...kperfvctqgplentcthfwqlalslgstsiillcgfvedgsekcakyisdivgfvdledh

NLYHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKcyrgRSCPIIVHCSDGAGRSGTYVLIDMVLNKM
 .|  |  ..       .    | . .    | .   . .. . || | |.| |  . | .   |.|       |.| ||| | ||.|| .||. ..  .
rvyteycteieiggkskdkithrvlkvvvkatgqesklnhyqwaswpdhgmpdscdtalrllsavkk....dkkpviahcsagvgrtgtlaliesmiaal

AKGAKEiDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEE
 .  |. ..  ..  || .|   |..  |. .|| .| | 
rhprkq.nvkdsfvllrkdrarsvrvfpqyvyalrcvlef
subfamily_Sponge-PTP-4_pd Subfamily Sponge-PTP-4 780-875 6.1e-07 23.8 In-house 3-82 (130) alignment 
Range on Protein: 780-875
Range on HMM: 3-82/130.0
LTYDHSRVLlkaenshsHSDYINASPIMDHDpRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENgvrqcYHYWPDegSNLYHIYEVNL
| .. ||.           .||||| .   . |   |. || || .|  |||.|. |    |.|.|  . |.       ||||  |. .. || ..
lefevsrlq........gntyinasfvGllg.rtaeylltqhpladtsmdfwkmmleryvnvlvvlgsveee.....deywpd..sePlewyeedi
0044763 (Phosphotyrosine protein) phosphatases II 782-997 4.7e-34 113.0 In-house 2-162 (178) alignment 
Range on Protein: 782-997
Range on HMM: 2-162/178.0
YDHSRVLLKAENSHSHSDYINASPIMDHdprnpAYIATQGPlpatvADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSnlyhiyevnlvsehiw
.|..||||     .  ||||||| |...      |.....|     ||......| |. .||.||.  |.|  .|..|||.| .                
ldrtrvllsnleglersdyinaseilpg.....lylgslpp.....addlellkelgithivnlteelelgflkcdpywpeeag................

cedflvrsfylknlqtnetrtvTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLNKmakgakEIDIAATLEHL
                       |.... . | |||.... .|.| . .....  . .|..|||| | ||||| |......         ... . .|..
......................iqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkkl......glsleeaielv

RDQRPgMVQTKEQFEF
| .|| .|.. .| ..
rerRp.ivpnpgqlrq
subfamily_Cele-PTP-1_pd Subfamily Cele-PTP-1 782-1002 1.7e-21 71.6 In-house 30-255 (290) alignment 
Range on Protein: 782-1002
Range on HMM: 30-255/290.0
YDHSRVLLKAENSHSHSDYINASPIMdhDPRNPAYIATQGPLPAT-------VADFWQMVWESGCVVIVMLTPLAENGVR----QCYHYWPDEGSNLYHI
  ..|| ||   ..  .||| |. .    | . . |.|| |. ..       . .|| |. .     .|||    |.       .| .| |..  .   .
veatrvvLkgygkrfnddyiHAnrvt..cpnglrliltqsPqekitekrnStiekfwwmakqEkvkqvVmlcefeeksantslfaCakYvpesvgeelkf

YEVNLV-SEHIWCEDFLVRSFYLKnLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNkCYrgrSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGA
  ...   . .  .|. .|   .|  . .|  |||   . .| .. |. ....||.  .||. ..     |.|||| ||  || .   |..   |.|.  
kgltvkCkskekeddvetRelvvk.fddeeeftvtHsllkgWnklnvqedtktllsliqkvk.as...ktpvivHcvdGiSrsAalaaiilgyQkiaets

KEIDIAATLEHLRDQRPGMVQTKEQFEFALTAV
... ... |. || ||  ........ |.. ..
gsvkledvlkalrkqralaitsalelafvdagi
0046846 (Phosphotyrosine protein) phosphatases II 795-1000 1.6e-39 130.8 In-house 9-167 (176) alignment 
Range on Protein: 795-1000
Range on HMM: 9-167/176.0
HSHSDYINASPIMDHdprnpAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYhiyevnlvsehiwcedflvrsfylkn
  ..|||||. |. .     ..|||||||| |.|||..|..| |. ..|.|| . | |  .|..|||.. .. .                          
dldldyinanlilgs.....rpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgi..........................

lqtnetrtvtQFHFLSWYDRGVPSSsRSLLDFRRKVNKCYRGRsCPIIVHCSDGAGRSGTYVLIDMVLNKmakgaKEIDIAATLEHLRDQRP-GMVQTKE
          |...| | | |||.. . ||.. . ......    |..|||| | ||.||.|.....  .     | ...  .|...|.||| |.||| |
..........qylhlpwpDhgvpdl.elllellefirealkeg.gpvlVHCsaGigRtgtlvaayllele.....kglsveealalvreqRplgavqtpe

QFEFALT
| .|   
Qyrflye
subfamily_Cele-PTP-19_pd Subfamily Cele-PTP-19 795-996 5.7e-29 95.8 In-house 77-271 (301) alignment 
Range on Protein: 795-996
Range on HMM: 77-271/301.0
HSHSDYINASpimdhdPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHI--YEVNLVS-EHIWCEDFLVRSFY
  |...|..|       .   .|||||||..|  ||| |.       ||||.   |. ...| .| | . |.  .|  ....... |.|  ..   |.. 
Pihanwipts......GhphrfiatqgPlkntsedfwamlvqydvekivmlgqkvekleekceeylpvkisekldigrfkikiknkelilnkkiskrtle

LKNLQ-TNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRgrscPIIVHCSDGAGRSGTYVLIDMvLNKMAKGAKEIDIAATLEHLRDQRPGMVQ
...     .||||| . . .| ||||| |   | |.   | |  .    ||.||||.| ||| ...  .. | .  .  ..|... .|.|||..|   ||
vedstgkfatrtvthyqysewtdrgvPkshaelfdlmelvkksek....PivvhcsaGiGrsvafigtey.lareveadptieltealkhlrehrwngvq

TKEQFE
|..|. 
tnsqly
0043147 (Phosphotyrosine protein) phosphatases II 796-998 1.1e-40 134.5 In-house 3-153 (172) alignment 
Range on Protein: 796-998
Range on HMM: 3-153/172.0
SHSDYINASPImDHDPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLaengvrqcyhywpdegsnlyhiyevnlvsehiwcedflvrsfylKNL
..|||||||.. |     . .|||||||. |.||||.|..| |. .||.||.|                                             ..
egsdyinasyl.dlyyipdrfiatqgplrntladfwrmlkelgithivnltel............................................lyd

QTNETRTVTQFHFLSWYDRGVPsSSRSLLDFRRKVNK-CYRGRSCPIIVHCSDGAGRSGTYVLIDMVLnkmakgaKEIDIAATLEHLRDQRPGMVQTKEQ
 ....|.. |...|.|.| ||| ... ||.| . ... . . ...|..|||| | ||.|| |.....|       . ...  .....|..|||.||...|
pellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.......lglsleeavalvrekRpgavqnpsq

FEFA
  | 
yrfl
0051429 (Phosphotyrosine protein) phosphatases II 797-1008 5.3e-44 146.2 In-house 3-227 (272) alignment 
Range on Protein: 797-1008
Range on HMM: 3-227/272.0
HSDYINASPIMDHdPR---NPAYIATQGPLPATVADFWQMvWESGCVVIVMLTPLAENGVRQCYHYWP------------DEGSNLYHIYEVNLVSEHiW
 |.||||. .     |     ......||||.|.||||.. .| |. .||.|... | |  .|. |||            .. . ||. . | |.||. .
lsgyiNardvggy.grvvkpgrlyrsggplpltaadfwrl.kelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllsee.l

CEDFLVRSFYLKNL-QTNETRTVTQFHFLSWYDRGVPSSSrsLLDFRRKVNKcyrgrSCPIIVHCSDGAGRSGTYVLIDMVLnKMAKGAKEID-------
..|...| ..|..| ...|.|.|...|...| |.|||...  ||.. . ...     . |..|||| | .|.||.|.....|         .|       
lldyilrellltlllsagearevmhlhytdwpdhgvpqea..llellellld.....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnl

-IAATLEHLRDQRPGMVQTKEQFEFALTAVAEEVNA
 .....|.||.||||.||| ||..| . |..| ...
yleeaveelraqrpgavqteeqylflyeallellrs
0051082 (Phosphotyrosine protein) phosphatases II 797-1001 1.1e-33 111.3 In-house 2-148 (151) alignment 
Range on Protein: 797-1001
Range on HMM: 2-148/151.0
HSDYINASPIMDHdprnpaYIATQGPLPatvaDFWQMVWESGCVVIVMLTPLAENGvrQCYHYWPDEGsnlyhiyevnlvsehiwcedflvrsfylknlq
.|||||.| . ..      .....|||.    ||.....| |. .||.|... |.|   |..|.|..|                                
lsdyinfsyvtgg......lyrsggpla....dflellkelgiktivnlrseeerg..ycpeylpelg................................

tnetRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKcyrGRSCPIIVHCSDGAGRSGTYVLIDMVLNKmakgakeIDIAATLEHLRDQRPGMVQTKEQFE
    ..|.....|.| | |.| |  ..|.| .....    .. |..|||| | ||.|| |.....| .       ......||..| .|||.||...|| 
....ievlhipildwpdpglplsfdavleflellld...kkngpvlvHCsaGkgRTGtlvalylmllg.......vsleealeeyrlkrpgvvqpnqqfl

FALTA
| | |
fqlfa
0036282 (Phosphotyrosine protein) phosphatases II 798-997 3.5e-40 132.9 In-house 2-161 (174) alignment 
Range on Protein: 798-997
Range on HMM: 2-161/174.0
SDYINASPImDHDPRNPAYIATQGPLPatvadFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDegsnlyhiyevnlvsehiwcedflvrsfylknLQT
||||||||. |   ..| .||.||||.     ||.|..| |. ..|||... |.|   |..|||.                                |..
sdyinaspl.dlsyitprliagqgpla.....fwemlkelgittvvmlleekelglykcinywpe................................lre

NETRTVTQFHFLSWYDRGVPSSSRsLLDFRRKVNKCYRG-RSCPIIVHCSDGAGRSGTYVLIDMVLNKMAkgAKEIDIAATLEHLRDQRPGMVQTKEQFE
 ..|.. |...| | |.|||..|  ||.| . |....   ...|..|||| | ||.|| |.....|  .    . .|. ...  || |||||||| .|..
dlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaGvgRtGtlvaaylmlrgll..eslvdaldlvrelRlqrpgmvqtpsQyr

F
|
f
0049260 (Phosphotyrosine protein) phosphatases II 810-998 2.9e-40 132.8 In-house 5-142 (152) alignment 
Range on Protein: 810-998
Range on HMM: 5-142/152.0
DPRNPAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWpdegsnlyhiyevnlvsehiwcedflvrsfylknlqtnetrtvtQFHFL
  .. ..||||||.| |.||||.|..| |. .||||| | |.|  .|..|.                                            |...|
yampfefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyi............................................qylhl

SWYDRGVPSSSRSLLDFRRKVNKCYRGRSCPIIVHCSDGAGRSGTYVLIDMVLnkmakgaKEIDIAATLEHLRDQRPGMVQTKEQFEFA
 | | |||..|  ||.. . ..|... ...|..|||| | ||.||.|.....|       . ...  .....| .|||.|....| .| 
pwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.......lgvsleeavalvrekRpgavpnpgqlrfl
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 814-862 3.9e-07 23.8 In-house 236-281 (440) alignment 
Range on Protein: 814-862
Range on HMM: 236-281/440.0
PAYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAEngvRQCYHYWPD
 |.|||| || .|| |||..| .     |.||  | .   . |  ||| 
nafiatqmpldstvldfwrlvhdyristiimlnqlnd...ktcsiywpv
subfamily_Anemone-PTP-3_pd Subfamily Anemone-PTP-3 815-997 3.5e-24 80.1 In-house 6-195 (199) alignment 
Range on Protein: 815-997
Range on HMM: 6-195/199.0
AYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWC-EDFLVRSFYLKNLQTN--ETRTVTQFHFLSW
 ||||| ||  |.|||||||||.|   |||.     |   .   |||   |   .   ...... | .  |. . .. | |  |    || .... | ||
ryiatqhplretmadfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

YDRGVPSSSR--SLLDFRRKVNKCYR-GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAK-GAKEIDIAATLEHLRDQRPGMVQTKEQFEF
 ..  |  .    ..   |.| | |   . .|.||||||| | .| .| .|. .    .  .  .|.      ||. | |.. . ....|
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf
subfamily_Nvec-PTP-3_pd Subfamily Nvec-PTP-3 815-997 3.5e-24 80.1 In-house 5-194 (198) alignment 
Range on Protein: 815-997
Range on HMM: 5-194/198.0
AYIATQGPLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWC-EDFLVRSFYLKNLQTN--ETRTVTQFHFLSW
 ||||| ||  |.|||||||||.|   |||.     |   .   |||   |   .   ...... | .  |. . .. | |  |    || .... | ||
ryiatqhplretladfwqmvwetgsghivmvnddqknkeadypfywpttesgtgkygslsvttktittkpdytitaliltnnttappstreishyqftsw

YDRGVPSSSR--SLLDFRRKVNKCYR-GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAK-GAKEIDIAATLEHLRDQRPGMVQTKEQFEF
 ..  |  .    ..   |.| | |   . .|.||||||| | .| .| .|. .    .  .  .|.      ||. | |.. . ....|
kekttpnvalfvgfvvasrevskkyeqekdapvivhcsdgqgftgvfvaldigvrsheesktsvvdlfevakrlrqarcgiisslqhynf
subfamily_Cele-PTP-9_pd Subfamily Cele-PTP-9 818-1003 6e-25 82.8 In-house 39-218 (255) alignment 
Range on Protein: 818-1003
Range on HMM: 39-218/255.0
AtqgplpaTVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHiWCEDFLVRSFYLK-NLQ-TNETRTVTQFHFLSWYDRG
        ||. |.|..  ..  |.|||. .||.|| .| .|.| |  .   . .||... .    | ..|   .  .|    .|.||. ...  | .. 
l.......tvdkfyqtivqtktevvvmlcdfaeegvekcssyfplekdeklkladvnvtttk.ssadvvlrtleitstlgekkkthtvkhysykGWiekn

VPSSSRSLLDFRRKVNKcyrgrSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKG-----AKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVA
 |  .| .|   . | .     | ...|||| | ||| ..||...|  || .      . |.|    ||.|| .|.. ..|  |. |..  | 
aPelareilnilkvvrd.....sksvvvhCstGiGrsaafvlaelvyqkmirsldttetveldylslleelrskrkraihtPlqlafsilmvl
subfamily_hpo-7_pd Subfamily hpo-7 818-1002 4.1e-23 76.6 In-house 42-223 (263) alignment 
Range on Protein: 818-1002
Range on HMM: 42-223/263.0
AtqgpLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSNLYHIYEVNLVSEHIWCeDFLVRSFYLKN-LQ-TNETRTVTQFHFLSWYDRG
     |  |.. |.|..  ..  |.|||.  .|.|| .| .|.| |  .   . .||... ..   | |...  | . |.   .|.||... .  | .. 
l....lvqtidkfyqtivqtktevvvmLcDfneegvekcssyfPlekdekqklanvnvcttkvqs.dvllktlellstlgeKkkthtvkhysykgWiekn

VPSSSRSLLdfrrKVNKCYRGrSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKG-----AKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAV
 |  .|. |    .. |  |. | ...|||| | |||  ......|  || .      . |.|    ||.|| .|.. ..|  |. |..  |
dpelareil....nilkvarn.skslvvhcstGiGrsaafsvaElvyqkmirsldttstveldylsLleelrssrkraihtPmqLafsilmv
subfamily_Cele-PTP-7_pd Subfamily Cele-PTP-7 822-1004 8e-15 49.1 In-house 99-286 (302) alignment 
Range on Protein: 822-1004
Range on HMM: 99-286/302.0
PLPATVADFWQMVWESGCVVIVMLTPLAENGVRQCYHYWPDEGSN--LYHIYEVNLVSEHIWCEDF------LVRSFYLKNLQTN--ETRTVTQFHFLSW
|   |.  .| .. .    ..| |. . |.. ..| .|. |.  .   .  | |. || .   |.|       . .  .|| ...    .||  ..| .|
pkkstlekhwalieqynvaivvqlcsfvedeekkcaeyysdkvggelkfgrytvktvsvktdleeftdkksfklytveiknekkkkkvkktvdilafsaw

YDRGVPSSSRSLLDFRRkVNKCYRGRscpIIVHCSDGAGRSGTYVLIDMVLNKMAKgAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAE
 | | |  . . ||  .   ..|.     ..|||| | ||.|| | |   ..  .|  |  |..  .  .|. | | ||...|  . |  |. 
pdhGapkeaytaldilk.fcesykkn...vlvhcsaGvGrtGtlvaikyGiqlcsk.kkvtdllsivlpvrqcryGavqdeqqliylllcvtk
subfamily_PTPDC1_pd Subfamily PTPDC1 878-997 4e-08 27.9 In-house 58-167 (182) alignment 
Range on Protein: 878-997
Range on HMM: 58-167/182.0
EHIWCEDFLVRSFYLKNLQTNETRTVTqFHFLSWYDRGVPSSsRSLLDFRRKVNKCYRGRscPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKeidiaaT
||  |   | .| .  .|.    . .. .. ..| | ||.|  ...||  . |. . .     . |||  | || |  .   .| .|  ...|      .
ehasCGagleesGfsYdlealmeqgiy.vynfgwkDygvasl.eriLdivkvvafalqeg..kvavhChaGlGrtGvliacylvyakrltaek......a

LEHLRDQRPGMVQTKEQFEF
.. .|..||  .||.|| |.
iklvrskrpksiqtreqvel
0048076 (Phosphotyrosine protein) phosphatases II 882-1000 3.2e-24 80.7 In-house 36-137 (145) alignment 
Range on Protein: 882-1000
Range on HMM: 36-137/145.0
CedflvrsfylKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRsCPIIVHCSDGAGRSGTYVLIDMVLNkmakgaKEIDIAATLEHL
.           . .....|...|...|.| |.|||.... ||.| . ......   .|..|||| | ||.||.|.....|       . ...  .||..
l..........tselellerlgiqylylpwpDhgvpdllellleflefieealkeg.gpvlVHCsaGvgRtgtlvaaylmll......lgvsleealelv

RDQRPGMVQTKEQFEFALT
| ||||.|.. .|..| . 
rsqrpgavpnpgqlrflye
0048179 (Phosphotyrosine protein) phosphatases II 887-998 6.9e-23 76.4 In-house 33-137 (144) alignment 
Range on Protein: 887-998
Range on HMM: 33-137/144.0
VRSFYLKNLQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRgRSCPIIVHCSDGAGRSGTYVLIDMVLnkmakgAKEIDIAATLEHLRDQRP
| ..  .  .. ..|...|...|.| |.|||...  ||.| . ...... ...|..|||| | ||.||.|......       . ...  .|...| .||
vinlteeyepefleregiqylhlpwpDhgvpdllellleflefieeale.eggpvlVHCsaGvgRtgtlvaaylmk......klglsleealalvrsrrp

GMVQTKEQFEFA
|.|.. .|..| 
gavpnpgqlrfL
subfamily_Urchin-PTP-2_pd Subfamily Urchin-PTP-2 895-1005 5.6e-20 66.1 In-house 83-193 (440) alignment 
Range on Protein: 895-1005
Range on HMM: 83-193/440.0
LQTNETRTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCY-RGRSCPIIVHCSDGAGRSGTYVLIDMVLNKmAKGAKEIDIAATLEHLRDQRPGMVQTKE
..  |.||. |.|. .| |.|||  .  .| . . ||..  .  . |..|||| ||||.|  . .| .| . || . .||| . .. .|..|| |||| |
ingiesrtlkqyhyqgwpdkgvpkfagpvlkmiqdvnesqekagngpllvhcsagagrtgviiavdsilre.akrsdqidifsfinsmrnnrpqmvqtpe

QFEFALTAVAEE
|. |   || | 
qyafvheavleg
0038934 (Phosphotyrosine protein) phosphatases II 901-1000 5.6e-09 31.4 In-house 77-171 (194) alignment 
Range on Protein: 901-1000
Range on HMM: 77-171/194.0
RTVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRG-RSCPIIVHCSDGAGRSGTYVLIDMVLNkmakgaKEIDIAATLEHLRDQRPGMVQTKEQFEFAL
.   ... | . |.|.. |   ||.| . |.. ..   .. . |||  | ||.|| |   ..          ..  . ....|. |||.... ...|  |
kagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyr......lgmsaeeAialfrekRpgaipnqdyleall

T
.
k
PTPc_DSPc_SM00012 902-1004 2.9e-32 106.3 In-house 1-105 (105) alignment 
Range on Protein: 902-1004
Range on HMM: 1-105/105.0
TVTQFHFLSWYDRGVPSSSRSLLDFRRKVNKCYRGRS--CPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFAL
||...|...| | |||..| |.|.. |.|.|... ..   |..||||.|.||.||.|..|..|... |. ||.||  ....||.||||||||.||. | .
tvkhyhytgwpdhgvPeesdsilellravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmvqteeqylfly

TAVAE
.|..|
ralle
subfamily_DSP23_pd Subfamily DSP23 926-996 5.4e-06 21.1 In-house 73-136 (148) alignment 
Range on Protein: 926-996
Range on HMM: 73-136/148.0
FRRKVNKCyRGRSCPIIVHCSDGAGRSGTYVLIDMVlnKMAKgakeIDIAATLEHLRDQRPGMVQTKEQFE
| | |..    ..  . |||  | ||.|| .   .|  |. |    .  | ..  .| .||| |.| || .
fvrvveea.eekneavsvhcllgrgrtgtmlacylv..kerk....laaaeaiaevrrlrpgsvetveqek
subfamily_Fungi-PTP1_pd Subfamily Fungi-PTP1 933-1001 5e-11 36.9 In-house 257-339 (350) alignment 
Range on Protein: 933-1001
Range on HMM: 257-339/350.0
CYRGRSCPIIVHCSDGAGRSGTYVLIDMVLN------KMAKGAKEID--------IAATLEHLRDQRPGMVQTKEQFEFALTA
    || ||.|||| | || ||.| .|..|.      .. |  ...|        |  .. .|| ||  |||...|| |   |
ldnarsspilvhCsaGvGrtGtlvtlDsllsdfeilenltkesrkldvaaktrDlisiivnelrkqrismvqnldqfifiYea
subfamily_CG42327_pd Subfamily CG42327 935-1001 1.7e-13 45.0 In-house 244-310 (319) alignment 
Range on Protein: 935-1001
Range on HMM: 244-310/319.0
RGRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTA
| .  |..||||||.||.|. .  |. .... .  . .||  .. ..| .|   |.||||.||    
resqGPlvvhcsdGvGrtGlviasdiairsleeskrsvdiPqlvssvrrdrasavltkeqyefiykv
subfamily_Fungi-PTP2_pd Subfamily Fungi-PTP2 935-1000 1.4e-07 25.1 In-house 262-338 (349) alignment 
Range on Protein: 935-1000
Range on HMM: 262-338/349.0
RGRSCPIIVHCSDGAGRSGTYVLIDMVLN----------KMAKGAKEID-IAATLEHLRDQRPGMVQTKEQFEFALT
  .. ...|||| | ||.|..| .|..|.          |.   |.  | |  .. .|| ||  |||   || . . 
tdqlstllvhcsaGcGrtGvlvtldlllsileplqnesnkiklqallkDlisiivnelrkqrismvqnlaqfiaiye
subfamily_Choan-PTP-4_pd Subfamily Choan-PTP-4 936-1006 4.3e-15 50.3 In-house 226-295 (297) alignment 
Range on Protein: 936-1006
Range on HMM: 226-295/297.0
GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAkEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEEV
 |. ...|||| | ||||  || |..|.|. |.    |.|| |..||.||. .||| ||||.  .|| . .
prnayllvhcsaGvGrsGvvvlsdvilaklrkkr.ipdvaailsilreqrarlvqtleqfellydavlkkl
subfamily_Cele-PTP-17_pd Subfamily Cele-PTP-17 936-1002 3.8e-06 20.6 In-house 269-334 (347) alignment 
Range on Protein: 936-1002
Range on HMM: 269-334/347.0
GRSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGaKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAV
..  |..| |  |  || | ||  ...... .| |  |  . . ..|||| |.      . .|. | 
eklapvvvmcdlgldrsatvvltsiiieqvldg.ktpdcddlfkkmrdqragvftmsifytyairaa
subfamily_Sponge-PTP7_pd Subfamily Sponge-PTP7 942-1005 5.8e-09 30.2 In-house 1-63 (69) alignment 
Range on Protein: 942-1005
Range on HMM: 1-63/69.0
IVHCSDGAGRSGTYVLIdMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEE
.|||| |.||.||.. | ||     |  | .||   ....|  || ||  .... |   |..| 
vvhcssGtGrtGtfiai.mvemarikseklvdifnnvqymrkcrpmmvmneneymfihdalvea
subfamily_Sponge-PTP-7_pd Subfamily Sponge-PTP-7 942-1005 6.7e-09 30.0 In-house 2-64 (69) alignment 
Range on Protein: 942-1005
Range on HMM: 2-64/69.0
IVHCSDGAGRSGTYVLIdMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFALTAVAEE
.|||| |.||.||.. | ||     |  | .||   . ..|  || ||  . .. |   |..| 
vvhcssgtgrtgtfiai.mvemarikseklvdifnnvqymrkcrpmmvmneieyifihdalvea