Gene FIG4 in Homo sapiens

Synonym: ALS11, BTOP, CMT4J, KIAA0274, SAC3, YVS, dJ249I4.1, RP1-249I4.1, FIG4

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily FIG4
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP107_AA protein Get Run
HsapP107_AA_249-595 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Sac_COG5329 14-179 5.2e-15 45.6 In-house 2-159 (1070) alignment 
Range on Protein: 14-179
Range on HMM: 2-159/1070.0
KLVLYETRARYFLVGSNNAETKYRVLkidRTEPKDLVIIDDRHVYTQQEVRELLGRLDLGnrtkmgqkgssglfraVSAFGVVGFVRFLEGYYIVLITKR
|..|.|.  |   ..||. ..  | |     ....|.....  |.....  | . .|                      .|| |.. . . ... .||. 
killsekktRsiaivsnkyalvfrrl...svknselsvcaaelvavselkkegfrslssa................heiygvlGlielegslflivitgk

RKM-ADIGGHAIYKVEDTNMIYIPNDSVRVTHP--DEARYLR--------IFQNVDLSSNFYFSYSYDLSHSLQYNL
 |  . |.|..|||...  .| . |..        |||..          ... ..  . ||||. .|.. .|| .|
skvaqvipgetiykilavdfislnnnkwddeeiesdeasteklrsehpcselkkLlsngsFYfStdfditntLqkrl
subfamily_FIG4_pd Subfamily FIG4 15-624 1.7e-277 912.4 In-house 1-567 (569) alignment 
Range on Protein: 15-624
Range on HMM: 1-567/569.0
LVLYETRARYFLVGSNNAETKYRVLKIDRTEPKDLVIIDDRHVYTQQEVRELLGRLDLGNRTkmgqkgssGLFRAVSAFGVVGFVRFLEGYYIVLITKRR
||||||.||..|||||..|||.||||||||....||...|....|..|..||| .|. .||.        || ..|||.|..||||||||||..|.|||.
lvlyetkarlylvGsnkretkfrvlkidrtverelvvledkveftkneikellasleeanrd........glekkvsayGilGfvrflegyylilvtkrk

KMADIGGHAIYKVEDTNMIYIPNDSVR-VTHPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTvlrmplemlksemT----QNRQESFDIFEdegl
|.| ||||||||.||...|.|..||..  ...||||||..|..|||..||||||||||...||.||.             .    ...... |  .    
kvaviGghaiykiedialikitedskksekssdearylklfkdvdltknfyfsysydltrtlqtnll.............lsdsnrekekaedrvd....

ITqggsgVFGICSEPYMKYVWNGELLDIIKSTVHR-DWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDA
||     .    ..   |.||| .||...|.||.. ||||.|||||. |||. ..|...||||||||||||||.||||||.|..||||||||||||...|
it.....ieakkldanekfvWnnflleplkdtvktfdWlleiihGfvsqskisvlgksiyvtliarrsskfaGarflkrGvnnkGdvaneveteqivhea

SVMSFTAGSYSSYVQVRGSVPLYWSQDISTMMPKPPITLDQADPFAHVAALHFDQMFQRFGSPIIILNLVKEREKRKHERILSEELVAAVTYLNQFLPPE
| .|.....|||.||.|||||||||||.|....||||..|..||||..||||||..|||.|||||||||||..||||.|.||.||. ||..|||.|||.|
segsldsdryssfvqlrGsvPlyWsqdasklvtkPpikidvvdPfasaaalhfddlfqryGspiiilnlvkkkekrkresilleefeaaieylneflPee

HTIVYIPWDMAKYTKSKLCNVLDRLNVIAESVVKKTGFFVNRPDSYCSIlrpdekwnelggcviptgrLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQ
... || ||||...||| .|||. |. .||..|||||.|...||.....                   .|.||.||||||||||||.|||..||.||.||
kklkyiswdmaraskskeenvlevlekyaeksvkktGiflsapdlestk...................iqeGivrtnCvdcldrtnaaqfvigkvalgyq

LYSLGLIDKPNLQFDTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPHLW
|.|||.||...|.||.|.|||.||||||.||||.|||||||||...|||||||.|...|.||..||.|||||.|.|||.||.|||||||..|.||.|.||
lkslGiidesklefdsdvvrlleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdainlflGvyspreglpslW

ELPTDFYLHHKNTMRL
||.||||||......|
eletdfylhnayslkl
subfamily_SAC1_pd Subfamily SAC1 90-181 3.1e-20 63.2 In-house 5-99 (458) alignment 
Range on Protein: 90-181
Range on HMM: 5-99/458.0
VSAFGVVGFVRFLEGYYIVLITKRRKMADIGGHAIYKVEDTNMIYIPNDSVRVTHP---DEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTV
|. .|..|... | | |...|||..... | |. ||.|.|...| . . |.  |.    .|..||.. ..|  |..||||| |||..||| .  |
vkiagilGiikLlsgkylivitkkeevgringkviyrvadveiipvkknslslteeqkkeekeylkllelvlksetfYfsytydltnslqrlekv
Syja_N SacI homology domain 92-424 8.6e-87 282.2 Pfam-A 1-314 (319) alignment 
Range on Protein: 92-424
Range on HMM: 1-314/319.0
AFGVVGFVRFLEGYYIVLITKRRKMADIG-GHAIYKVEDTNMIYIPNDSVRVT---------HPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTV
|.|..|..|.|...|...||||.|.|.|. .| |||......| ..... . .         ...|...|. ..... |..|||||.|||..||| . . 
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

LRMPLEMLKS-EmtqnrqesfdifedeglitqggsgvfGICSEPYMKYVWNGELLDIIKSTV--HRDWLLYIIHGFCGQSKLLIY-GRPVYVTLIARRSS
 .   |  ..                               .|. ...|||  ||. ..       .|||..|.||..|... .  .. |..|||.|||.
eeeekeeesksl..........................pllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsv

KFAGTRFLKRGANCEGDVANEVETEQILCDA-SvmsfTAGSYSSYVQVRGSVPLYWSQdISTMMPKPPITLD-QADPFAHVAALHFDQMFQRFgSPIIIL
|.||||.|.||.. .|.|||.||||||...  .    ..... |.||.||||||.|.|  |....||.|... . ..  .....||.....|. ..|...
kraGtRylrRGidddGnvANfvEtEqivsekke....eskrvfSfvqiRGSvPlfWeq.asnlslkpkikitrsseasqkafkkHfkklikrY.gkivvv

NLVkerEKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKS
||.   ||...|. |||.. .....||..|. .. . || .|. | .|.
nLl...ekkgrEkkLseayeelinklnkklkekkklkyiefDfhkeckg
Syja_N SacI homology domain 92-424 8.6e-87 282.2 In-house 1-314 (319) alignment 
Range on Protein: 92-424
Range on HMM: 1-314/319.0
AFGVVGFVRFLEGYYIVLITKRRKMADIG-GHAIYKVEDTNMIYIPNDSVRVT---------HPDEARYLRIFQNVDLSSNFYFSYSYDLSHSLQYNLTV
|.|..|..|.|...|...||||.|.|.|. .| |||......| ..... . .         ...|...|. ..... |..|||||.|||..||| . . 
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

LRMPLEMLKS-EmtqnrqesfdifedeglitqggsgvfGICSEPYMKYVWNGELLDIIKSTV--HRDWLLYIIHGFCGQSKLLIY-GRPVYVTLIARRSS
 .   |  ..                               .|. ...|||  ||. ..       .|||..|.||..|... .  .. |..|||.|||.
eeeekeeesksl..........................pllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsv

KFAGTRFLKRGANCEGDVANEVETEQILCDA-SvmsfTAGSYSSYVQVRGSVPLYWSQdISTMMPKPPITLD-QADPFAHVAALHFDQMFQRFgSPIIIL
|.||||.|.||.. .|.|||.||||||...  .    ..... |.||.||||||.|.|  |....||.|... . ..  .....||.....|. ..|...
kraGtRylrRGidddGnvANfvEtEqivsekke....eskrvfSfvqiRGSvPlfWeq.asnlslkpkikitrsseasqkafkkHfkklikrY.gkivvv

NLVkerEKRKHERILSEELVAAVTYLNQFLPPEHTIVYIPWDMAKYTKS
||.   ||...|. |||.. .....||..|. .. . || .|. | .|.
nLl...ekkgrEkkLseayeelinklnkklkekkklkyiefDfhkeckg
subfamily_SAC1_pd Subfamily SAC1 227-600 5e-65 210.9 In-house 116-455 (458) alignment 
Range on Protein: 227-600
Range on HMM: 116-455/458.0
KYVWNGELLDII-KSTVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDAsvmsftaGSYSSYVQVR
...||. ||. . |.   ....| .|.||  ...| . ....  .||.||| . ||||. .||.. ||.||| ||||||.           . .|.||||
RffwnkhlledlrkepelesfilPvikGfikikelslnakeikfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqiveae.......kaltsFvqvR

GSVPLYWSQdISTMMPKPPITLDQADPFAHVAALHFDQMFQRFGSPIiILNLVkerEKRKHERILSEELVAAVTYLNqflppEHTIVYIPWDMAKYTKSK
||.||.||| ....  || ..| . .   .    |.|.  ...|. . ..|||   ... .|  | |..   |. ||     ...| |. .|  |  .. 
GsiPllWsq.kpnLkykPkvklsesedsldafkkhldeqielygenv.lvnLv...dqkGsEkklgeayesvvraln.....kkkikyvafDFHkeCrkm

LCNVLDRLNVIAESVVKKTGFFVNrpdsycsilrpdE---KwnelggcvipTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQF
  . |. |    |. ....|.|.             .   |          . . |.|..||||.|||||||  | .... .|  || |||.. . .   
rwdrlklLidqlekelsqegyflk............seekk..........ivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslgvlateskle

-DTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHP
  ..  . | .|. |..|..| || | .      |       .   .|.....|||| | |.|  |||||.|||| . .
dsaeletsfknlwadnadavsvqYaGtgAlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflgkyrv
subfamily_INPP5F_pd Subfamily INPP5F 227-598 3.8e-64 208.2 In-house 168-506 (951) alignment 
Range on Protein: 227-598
Range on HMM: 168-506/951.0
KYVWNGELLDIIKSTVHRD---WLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILcdaSVMSFtagsYSSYVQ
...||  ||. .  . ...   .|. .| ||.  ... |    | .||| ||| | ||||| .|| . .| |||.||||.||   || ..      |..|
rFfWNkfllkdlinyrdkldkefltpviqGfvetkeisieklkvsltlisrrSrkragtrfkrrGidddgnvAnfvEtElil...sveky....vlsftq

VRGSVPLYWSQDISTMMPKPPITLDQADPfAHVAALHFDQMFQRFGSpIIILNLVKErekRKHERILSEELVAAVTYLNqflppEHTIVYIPWDMAKYTK
.|||||..|.|. . . ||. || ....   ..   ||.. ....|  . | ||...   ...|..||.    ... |.     .. ...|  |. ..|.
irGSvPvfweqsgkkykpkikitrseeet.qpaFdehfkeqlkkygk.vvivnllsq...kssekklskaykeqllkle.....skdvflikfdfheets

SKLCNVLDRLNVIAESVVkktgffvnrpdsycsiLRPDEKWNELGGCVIptgRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQFD
..  . ...|.   .  .                ..    ...  . ||     |.|..||||.|||||||..| ...| .|  ||  |||..  .   |
gekfenvsklieliknei................kevgyfsydvkekvi...seqkgvfRtnclDcldrtNvvqqaiskavlelqleklglfepessidd

TDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVF
 . .. ...|. |.||..| || |.. .    |       .   || ....|||| | | |. ||. |.| ||  
eellqklkklWadngdaisrqYagtnalkgdltrkgerklaGvlkdgyksvsryylnnfkdkyrqkvidlllGkl
subfamily_Synaptojanin_pd Subfamily Synaptojanin 227-596 1e-42 137.5 In-house 105-434 (754) alignment 
Range on Protein: 227-596
Range on HMM: 105-434/754.0
KYVWNGELLDII-KSTV-HRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILcdasvmsFTAGSYSSYVQV
...||  |   . .  |  .|||| .. |      . .  . . ..||.| |.. |||||  ||.| || ||| |||||..       .   . .|.||.
rffWnrslhlhlqrfgvncddWllkvmcGsveirtvyagakqakaalisrlsceraGtrfnvrGvndeGnvanfveteqvi.......llddkvtsfvqi

RGSVPLYWSQDiSTMMPKPPITLDQADPFAHVA-ALHFDQMFQRFGSPiIILNLVkerEKRKHERILSEELVAAVTyLNQFlppEHTIVYIPWDMAKYTK
||||||.|.|     . .  . | ..   .. |   |..|. .|.|.  .|.||.    ... |..||..     .  ...   .. . .. .|. . .|
rGsvPlfWeqP.GlqvGshkvklsrgfeasaaafdrhleqlkeryGev.vivnll...Gskegeevlskafkkhlk.aseh...akdvpfvkfdyhqkvk

SKLCNVLDRLNV-IAESVVKKTGFFVNRpdsycsilrpDEKwnelggcVIptgRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQf
..  ..|..|   ...  .....||...          ...       |    . |||.||.||.|||||||. | ..|   |. ||  |.|  |...  
ggkkeklekllkkqlklflesasfflsk..........gke.......ve...keqtGvlrvnClDCldrtnavqtvlglevlekqlealklsskesvv.

dTDAVRLFEELYEDHGDTLSLQYGGSQLVHRVKTyrkiapwTQHSKDIMQTLSRYYSNAFSDADRQDSINLFL-G
 .   . |..|..  || .|  | |.. ..           .   ||  ....|   | | |. .|..|.|.| |
.srfeevfkslWsknGdeiskiyaGtgalegkak.......vsklkdgarsvartiqnnfldsskqeaidllllg
Sac_COG5329 229-641 4.3e-92 300.9 In-house 185-560 (1070) alignment 
Range on Protein: 229-641
Range on HMM: 185-560/1070.0
VWNGELLDIIKS--TVHRDWLLYIIHGFCGQSKLLIYGRPVYVTLIARRSSKFAGTRFLKRGANCEGDVANEVETEQILCDAsvmsftaGSYSSYVQVRG
... . |. ...     ...|  .|.||. . .  . .. .. |||.|||||.||||||.|| . .| |||.||||||. ..         . |..||||
inyrsklsslekqlldnagFlttvIrGFaetvfikvkkktiaLtlISRrSskragtRflarGvDddGnvanFVETEqIvyss.......qycfsFtQvRG

SVPLYWSQDiSTMMPKPPITLDQADP-FAHVAALHFDQMFQRFGSpIIILNLVKEREkrkHERILSEELVAAVTyLNQFLPPehtiVYIPWDMAKYTKSK
|.|..|.|. |. . .|.|   . .. .  ... |||. |.. |  . |.||.|. .   .|. |||..   .. |.....      .. .|. | |. .
SiPiFWeqe.snsligpkiqitrsseatqsafdkHFdklfekYGd.vhivNLlktKs...sEieLseryekhlk.lsekpki....hlteFdfhketsqd

LCNVLDRLNVIAESVVKKTGFFVNrpdsycsilrpdekwnelGGCVIPTGRLQTGILRTNCVDCLDRTNTAQFMVGKCALAYQLYSLGLIDKPNLQfdtD
  ... .|   .|. ..  |.|                     .    .   |.|..|||| |||||||..|....| .|  |..|.. |.. . .   |
gfddvkkLlplieqdllefgyfsy..................dvkegkliseQdGVfRtNClDCLDRTNviQqliskrvlleqfrsikvisaidde...d

AVRLFEELYEDHGDTLSLQYGGSQLVHRVKTYRKIAPWTQHSKDIMQTLSRYYSNAFSDADRQDSINLFLGVFHPTEGKPHLWELPTDFYLHHKntMRLL
 .  ..||. |.||..| .|.|.. . .  |....  .  ...|...  ||.|.| | |. .||.|.|.|| . . |. . ...  ....|. .   .. 
flqklneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllLgklpdqeavelydpineyvnlrlr..kses

PTRRSYTYWWTPEVIK
  ......... . ..
eftaaknvsiftltfn