Gene SACM1L in Homo sapiens

Synonym: SAC1, SACM1L

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family Sac
Subfamily SAC1
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP109_AA protein Get Run
HsapP109_AA_188-499 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_INPP5F_pd Subfamily INPP5F 30-507 7.8e-125 409.1 In-house 43-511 (951) alignment 
Range on Protein: 30-507
Range on HMM: 43-511/951.0
VLTIDRVStevTLAVKKDVPPSAVTRPIFGILGTIHLVAGNYLIVITKKIKVgeffSHVVWKATDFDVLSYKKTML-HLTDIQLQDNKTFLAMLNHVLNV
|..|.||    .| .... ..   .  ..|..| |.| .  .. .|..| ||     .  |.. | |. .|...   . .  . . .|  |  |.. |. 
vvaierva...kldlsekdskelekeectgliglielegkiivatiegkskv....nnkkwdlididssgylqlkeekeqneeeklekrlleelkkllsd

DGFYFSTTYDLTHTLQRLSNTSPEFQEMSLleraDQRFVWNGHLLRELSAQPEVH--RFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVR
. ||.|...|||.|||. .... . .        |.||.|| .||..| .  . .  .| .||. ||. ....||. . ..  |||||| .||| |.. |
gsFYysldfDltntlqkrgleeksestddw....derFfWNkfllkdlinyrdkldkefltpviqGfvetkeisieklkvsltlisrrSrkragtrfkrr

GIDSEGHAANFVETEQIVHYNGSKASFVQTRGSIPVFWSQRpNLKYKPLPQISKV-ANHMDGFQRHFDSQVIIYGKQVIINLINQKGSEKPLEQTFATMV
||| .|. |||||||.|.. .    ||.| |||.||||.|. . |||| ..| .  ..    |..||..|.  |||.||.||..||.||| | ..... .
GidddgnvAnfvEtElilsvekyvlsftqirGSvPvfweqs.gkkykpkikitrseeetqpaFdehfkeqlkkygkvvivnllsqkssekklskaykeql

SSLGSGMMRYIAFDFHKECKNMRWDRLSILLDQVAEMQDELSYFLVDSAGQVVANQEGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLE
  | |  . .| ||||.|....... .| |.... .   |  || .|. ..|...|.|||| ||.||||||||.|. ...  |. ||..||...  ....
lkleskdvflikfdfheetsgekfenvsklielikneikevgyfsydvkekviseqkgvfRtnclDcldrtNvvqqaiskavlelqleklglfepessid

EqDEFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTHLGLIMDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYSVDEL
. .|. . .|. |||| .|  .||||| ||| |.||.|.|   |.. || .|. ||| ||| | .||. ||| ||.   .| 
d.eellqklkklWadngdaisrqYagtnalkgdltrkgerklaGvlkdgyksvsryylnnfkdkyrqkvidlllGklpkqev
subfamily_SAC1_pd Subfamily SAC1 55-506 6.4e-218 714.9 In-house 5-457 (458) alignment 
Range on Protein: 55-506
Range on HMM: 5-457/458.0
RPIFGILGTIHLVAGNYLIVITKKIKVGEFFSHVVWKATDFDVLSYKKTMLHLTDIQLQDNKTFLAMLNHVLNVDGFYFSTTYDLTHTLQRLSN-TSPEF
. |.||||.|.|..|.|||||||| .||.. ..|.....|......||..|.||. | ...|..|..|..||. ..||||.|||||..||||.. ||...
vkiagilGiikLlsgkylivitkkeevgringkviyrvadveiipvkknslslteeqkkeekeylkllelvlksetfYfsytydltnslqrlekvtsaal

QEMSLLERADQRFVWNGHLLRELSAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYNGSKASF
.|.|||||||.||.||.|||..|...||...| |||..|||.....|.|.| ...|||||||.||||.||.|||.|.||..||||||||||... ...||
kerslleradeRffwnkhlledlrkepelesfilPvikGfikikelslnakeikfilisRRsifRaGtRyfvRGvdkeGnvanfvEtEqiveaekaltsF

VQTRGSIPVFWSQRPNLKYKPLPQISKVANHMDGFQRHFDSQVIIYGKQVIINLINQKGSEKPLEQTFATMVSSLGSGMMRYIAFDFHKECKNMRWDRLS
||.|||||..|||.||||||| ...|. ....|.|..|.|.|. .||..|..||..||||||.|.......|..|.. ...|.||||||||..||||||.
vqvRGsiPllWsqkpnLkykPkvklsesedsldafkkhldeqielygenvlvnLvdqkGsEkklgeayesvvralnkkkikyvafDFHkeCrkmrwdrlk

ILLDQVAEMQDELSYFLVDSAGQVVANQEGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLEEQDEFEKIYKNAWADNANACAKQYAGTG
.|.||....... .|||.......|..|.||.|.||.||||||||.||||||..||.||..||||....|||...|.|...||.|||||.|...||||||
lLidqlekelsqegyflkseekkivkeqkgvvRtnCiDcLDRtnvvqsllarevLqkqleslgvlateskledsaeletsfknlwadnadavsvqYaGtg

ALKTDFTRTGKRTHLGLIMDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYSVDE
|||||||||||||.||...||.||..|||||||.||.||||||||||.|.|..
AlKtDftRtGkrtllGalrDgvnsvsryyknnfldgerqdsidLflgkyrvet
Sac_COG5329 55-506 1.3e-131 431.7 In-house 59-523 (1070) alignment 
Range on Protein: 55-506
Range on HMM: 59-523/1070.0
RPIFGILGTIHLVAGNYLIVITKKIKV-GEFFSHVVWKATDFDVLSYKKTMLHLTDIQ--LQDNKT-----FLAMLNHVLNVDGFYFSTTYDLTHTLQRL
  |.|.|| | |   ..|||||.| || . . .. . |  ..|..|...      .|    .. ..      .  |  .|  . |||||..|.| |||. 
heiygvlGlielegslflivitgkskvaqvipgetiykilavdfislnnnkwddeeiesdeasteklrsehpcselkkLlsngsFYfStdfditntLqkr

SNTSPEFQemslLERADQRFVWNGHLLREL----SAQPEVHR-------FALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAA
... .| .     ..||..|.||  ||.||    |  ..          |  .| .||..  . ....|     ||||||  ||| |.  ||.| .|..|
lkeelels....vdtadeefmwnsflleelinyrsklsslekqlldnagFlttvIrGFaetvfikvkkktiaLtlISRrSskragtRflarGvDddGnva

NFVETEQIVHYNGSKASFVQTRGSIPVFWSQRPNLKYKPLPQISK-VANHMDGFQRHFDSQVIIYGKQVIINLINQKGSEKPLEQTFATMVSSLGSGMMR
|||||||||  .    ||.|.|||||.||.|  |. ..|  ||.. . .  . |..|||...  ||...|.||...|.||..| . .   .  .    . 
nFVETEqIvyssqycfsFtQvRGSiPiFWeqesnsligpkiqitrsseatqsafdkHFdklfekYGdvhivNLlktKssEieLseryekhlklsekpkih

YIAFDFHKECKNMRWDRLSILLDQVAEMQDELSYFL-VDSAGQVVANQEGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVGQKLeeqdEFEKI
.. ||||||......|... ||.....   |  ||    . |.... |.||||.||.||||||||||.|...| |. |.. ..|   ...     .| ..
lteFdfhketsqdgfddvkkLlplieqdllefgyfsydvkegkliseQdGVfRtNClDCLDRTNviQqliskrvlleqfrsikvisaidde....dflqk

YKNAWADNANACAKQYAGTGALKTDFTRTGKRTHLGLIMDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYSVDE
... ||||..| ...| ||||||..|||.|||.  | . |  .|. |.| ||| |. .||.|||.|| .. .|
lneLWadnGDaisqiYTGtgalkssftrkgkrsiagalsDatkSvsRmyinnfvDkekQdaidllLgklpdqe
Syja_N SacI homology domain 57-350 1.1e-93 304.9 Pfam-A 1-318 (319) alignment 
Range on Protein: 57-350
Range on HMM: 1-318/319.0
IFGILGTIHLVAGNYLIVITKKIKVGEFF-SHVVWKATDFDVLSYKKTMLHLTDIQ------LQDNKTFLAMLNHVLNVDGFYFSTTYDLTHTLQRLSNT
..||||.|.| ...||.||||. ||...  .| ..| ....... ...  . . |.       .... .|..|. .|. ..||||..||||..||| |..
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

SPEFQE-----MSLLERADQRFVWNGHLLRELSAQ-PEVHRFALPVLHGFITMHSCSIN-GKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQ
. | .|     ..||...|.||||| .||..|    ....|. ||...||....|.... .| ....||||||. |||.||  ||||..|..||||||||
eeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEq

IVH-Y-N--GSKASFVQTRGSIPVFWSQRPNLKYKPLPQIS-KVANHMDGFQRHFDSQVIIYGKQVIINLINQKGSEKPLEQTFATMVSSL-----GSGM
||.   .  ..  ||||.|||.|.||.| .||..|| ..|. .  .. . |..||....  |||.|..||...||.||.|..........|      .  
ivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkk

MRYIAFDFHKECKNMRWD
..||.||||||||.....
lkyiefDfhkeckgkkfe
Syja_N SacI homology domain 57-350 1.1e-93 304.9 In-house 1-318 (319) alignment 
Range on Protein: 57-350
Range on HMM: 1-318/319.0
IFGILGTIHLVAGNYLIVITKKIKVGEFF-SHVVWKATDFDVLSYKKTMLHLTDIQ------LQDNKTFLAMLNHVLNVDGFYFSTTYDLTHTLQRLSNT
..||||.|.| ...||.||||. ||...  .| ..| ....... ...  . . |.       .... .|..|. .|. ..||||..||||..||| |..
aygilGlirllsesyllvitkrekvakirgehpiykiksvefiplnseeeessaieeekeeeekeeekllkllkkllssgsfYfSydyDltrslqrksek

SPEFQE-----MSLLERADQRFVWNGHLLRELSAQ-PEVHRFALPVLHGFITMHSCSIN-GKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQ
. | .|     ..||...|.||||| .||..|    ....|. ||...||....|.... .| ....||||||. |||.||  ||||..|..||||||||
eeeekeeeskslpllkevderFvWNrnllkplielkldlsrwllpliqGfveqrsievkskkkveltLIsRrsvkraGtRylrRGidddGnvANfvEtEq

IVH-Y-N--GSKASFVQTRGSIPVFWSQRPNLKYKPLPQIS-KVANHMDGFQRHFDSQVIIYGKQVIINLINQKGSEKPLEQTFATMVSSL-----GSGM
||.   .  ..  ||||.|||.|.||.| .||..|| ..|. .  .. . |..||....  |||.|..||...||.||.|..........|      .  
ivsekkeeskrvfSfvqiRGSvPlfWeqasnlslkpkikitrsseasqkafkkHfkklikrYgkivvvnLlekkgrEkkLseayeelinklnkklkekkk

MRYIAFDFHKECKNMRWD
..||.||||||||.....
lkyiefDfhkeckgkkfe
subfamily_Synaptojanin_pd Subfamily Synaptojanin 57-509 3.6e-91 297.8 In-house 6-443 (754) alignment 
Range on Protein: 57-509
Range on HMM: 6-443/754.0
IFGILGTIHLVAG----NYLIVITKKIKVGEFFSHVVWKATDFDVLSYKKTMLHLtdiqlqdnkTFLAMLNHVLNVDGFYFSTTYDLTHTLQRLSNTspe
..|.|| ..| ||    ..|...|   .||      ..| |. ...| ...  .            .. |...|. . ||||.. | ...|.  ...   
aygllGvlrlnagdetlsflvlvtgcksvGkisdaeifkitstelvslrseasde.........driielkkllasgtfyfsssadsasrldlslsa...

fQEMSLLERADQRFVWNGHLLRELSA-QPEVHRFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIVHYNGSKA
 |. .  |  |.||.||  |   |.  . . ... |.|. | ....   .  |    .|||| || |||.|..|||.. ||..||||||||..  . . .
.qrrkqeesednrffWnrslhlhlqrfgvncddWllkvmcGsveirtvyagakqakaalisrlsceraGtrfnvrGvndeGnvanfveteqvillddkvt

SFVQTRGSIPVFWSQrPNLKY--KPLPQISKVANHMDGFQRHFDSQVIIYGKQVIINLINQKGSEKPLEQTFATM-VSSLGSGMMRYIAFDFHKECKNMR
||||.|||.|.||.| | |.   . .    ...     |.||....   ||..||.||. .|..|. |...| .   .|  .  . .. ||.|...|  .
sfvqirGsvPlfWeq.PGlqvGshkvklsrgfeasaaafdrhleqlkeryGevvivnllGskegeevlskafkkhlkasehakdvpfvkfdyhqkvkggk

WDRLSILLDQVAEM-QDELSYFLVdSAGQVVANQEGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGvlhVGQKLEEQDEFEKIYKNAWADNANACAK
 . |. ||......  .. |.||  . ..|. .|.|| |.||.||||||| .|..|.   |. ||. |.   ...| .  ..||...|. |  | . ..|
keklekllkkqlklflesasffls.kgkevekeqtGvlrvnClDCldrtnavqtvlglevlekqlealk...lsskesvvsrfeevfkslWsknGdeisk

QYAGTGALKTDfTRTGKrthlglIMDGWNSMIRYYKNNFSDGFRQDSIDLFL-GNYSVDELES
 |||||||... ....|      ..||  |. |  .||| |. .|..|||.| ||  |.|| .
iyaGtgalegk.akvsk......lkdgarsvartiqnnfldsskqeaidllllgntyveelad
subfamily_FIG4_pd Subfamily FIG4 57-506 7.2e-90 292.9 In-house 70-545 (569) alignment 
Range on Protein: 57-506
Range on HMM: 70-545/569.0
IFGILGTIHLVAGNYLIVITKKIKVGEFFSHVVWKATDFDVLSYKKTMLHltDIQLQDNKTFLAMLNHVLNVDGFYFSTTYDLTHTLQRLSNTSP-----
 .|||| .... | |||..||. ||.   .|...|  | .... .... .    .  |.. .| ....|     |||| .||||.|||  . .|      
ayGilGfvrflegyylilvtkrkkvaviGghaiykiedialikitedskk..sekssdearylklfkdvdltknfyfsysydltrtlqtnlllsdsnrek

-------EFQEMSLLERADQRFVWNGHLLRELSAQPEVHRFALPVLHGFITMHSCSINGKYFDWILISRRSCFRAGVRYYVRGIDSEGHAANFVETEQIV
       . .  .   .|...|||| .||  |... . ... | ..|||.. .. |. ||  . .||.|||   || |.  ||....|. || |||||||
ekaedrvditieakkldanekfvWnnflleplkdtvktfdWlleiihGfvsqskisvlgksiyvtliarrsskfaGarflkrGvnnkGdvaneveteqiv

HY-------NGSKASFVQTRGSIPVFWSQRP-NLKYKPLPQISKVANHMDGFQRHFDSQVIIYGKQVI-INLINQK---GSEKPLEQTFATMVSSLGS--
|        ... .||||.|||.|..|||   .|. ||  .| .|  ...   .|||. .  ||  .| .||. .|     |. |.. | . .. |    
heasegsldsdryssfvqlrGsvPlyWsqdasklvtkPpikidvvdPfasaaalhfddlfqryGspiiilnlvkkkekrkresilleefeaaieylnefl

---GMMRYIAFDFHKECKNMRWDRLSILLDQVAEMQDELSYFLVDSAGQVVANQEGVFRSNCMDCLDRTNVIQSLLARRSLQAQLQRLGVLHVgQKLEEQ
     ..||..|...  |.   . |..| .   ..  .  .||  .. . .. |||. |.||.|||||||. | ......|. ||..||...   ||| .
PeekklkyiswdmaraskskeenvlevlekyaeksvkktGiflsapdlestkiqeGivrtnCvdcldrtnaaqfvigkvalgyqlkslGiide.sklefd

DEFEKIYKNAWADNANACAKQYAGTGALKTDFTRTGKRTHLGLIMDGWNSMIRYYKNNFSDGFRQDSIDLFLGNYSVDE
 .  .. .. . |  .  | ||.|.   .|  | .  ...     |  ... ||| | |.|  .||.|.|||| ||  |
sdvvrlleelyedlGdtlalqygGsqlvntiktyrkiaqwssksrdiletlkryysnsfvdadkqdainlflGvyspre