Gene SCP3 in Homo sapiens

Synonym: C3orf8, HYA22, PSR1, RBSP3, SCP3, CTDSPL

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family FCP
Subfamily SCP
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP123_AA protein Get Run
HsapP123_AA_105-247 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
CPDc_SM00577 106-247 3.5e-49 158.5 In-house 2-145 (146) alignment 
Range on Protein: 106-247
Range on HMM: 2-145/146.0
KKCVVIDLDETLVHS-------SFKPISNADFIVPveidgtiHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRAR-LFRESC
||..|.|||||||||       ||.. |. |....       ..|.|||||.|||||... .|||.|.||.. .||||...||||. . .  | |.|..|
kkvLVlDLdetLvhsanmaepksfsevsptdslae.......tlvlvlkRPyvdeFLkkaaklfelvifTsaskkyadtildllDpkrllkyrvlyRqdc

VFHRGNYVKD-LSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTD
....|...|| || | ..||||.|.|||..|. ..||||...........|
rlvkgkllkddlsllkvdlskvviiDnseestlvnpenalkikpyisalsd
subfamily_DULLARD_pd Subfamily DULLARD 106-248 1.3e-47 153.3 In-house 1-152 (153) alignment 
Range on Protein: 106-248
Range on HMM: 1-152/153.0
KKCVVIDLDETLVHS--------SFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRW-GVFRARLFRES
.| .|.||||||.||        . ||  . ||.| | ||..  ..|| ||||||.||... . .. |.||||. .||..|.| ||.  |... |..|..
rktlvlDlDetlihsahdsvtkstvkpgtapdfvvkvlidkepvlfyvykrPhvDlfLdvvskWydlviftasmeeyaaavvdkLdsgrgilkrryyrqh

CVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDT
|| . |.|.|||| .  .||.|||.|||| .| ..|.||.|..||. | .||
CvlesgkytkdlslvssdlssviilDnspvayrknpdnaipikswlsdpsdt
subfamily_SCP_pd Subfamily SCP 107-248 1.4e-88 286.0 In-house 1-142 (142) alignment 
Range on Protein: 107-248
Range on HMM: 1-142/142.0
KCVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVK
||.|||||||||||||||..||||.||||||||.|||||||||||||||.|.|.|||.|||||||||||||||||||...|.||||||||||||.|||||
kclvidldetlvhssfkpvknadfvvpveidgtvhqvyvlkrphvdeflkrvgelfevvlftaslakyadpvadlldkkkvlrarlfrescvfhkgnyvk

DLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTDT
|||||||.|.||||||||||||||||||||||.|||||..||
dlsrlgrdlkkviivdnspasyifhpenavpveswfddkedt
NIF NLI interacting factor-like phosphatase 107-266 8.2e-54 173.8 Pfam-A 1-158 (159) alignment 
Range on Protein: 107-266
Range on HMM: 1-158/159.0
KCVVIDLDETLVHSSFKPISNADFIVPveiDgTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDR-WGVFRARLFRESCVFHRGNYV
|..|.|||||||||..|. .. |.  .   . . ....| |||..||||... . .| |.||||  .||.|| | ||.   .|..||.||||....|.||
ktLVLDLDetLvhskekkdlkedgkkv...e.ektkasvkkRPgldeFLkelskayevviftasskeyaepvldkldpkkklfkkrlyresctlrngkyv

KDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDD-MTDTELLDLIPFFEGLSREDDV
|||| |||.||.|.|||.|| |. ..|.|..|......|  .|||||.|.||.| |...|||
KdLsllgrdlsrvvivDdsprsfelqpdngipiepfygdsdkdtellkllpflealeksddv
subfamily_CTDSPL2_pd Subfamily CTDSPL2 108-247 8.3e-50 160.5 In-house 1-141 (142) alignment 
Range on Protein: 108-247
Range on HMM: 1-141/142.0
CVVIDLDETLVHSSFKPISNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGV-FRARLFRESCVFHRGNYVK
..|.||||||||.| ... .| .  ||. . ...|||| .||.. |||.|. .||| .|||||   ||| . ||||     .. |||||.||.  |||.|
slvldldetlvhcslekleeatltfpvlfenktyqvyvrlrpflreflervsklfevilftaskkvyadklldlldpekklikhrlfrehcvcvdgnyik

DLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDDMTD
||| |||.|.|.||||||| .. .  || .|..|||.| .|
dlsilGrdlektiivdnspqafayqlenGipieswfedend
subfamily_FCP1_pd Subfamily FCP1 108-237 1.9e-15 49.2 In-house 3-138 (146) alignment 
Range on Protein: 108-237
Range on HMM: 3-138/146.0
CVVIDLDETLVHSSFKPI-----SNADFIVPVEIDGTIHQVYVLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWG-VFRARLFRESCVFHR
..|.|||.||.|.. .|.     ..   |   ..  . .  || .||.. |||... .|.|  ..| .  .||. .| .||  . .|  |..    ... 
vLvvDlDqtlihttkdptievkeekkkdikkftlpeekevyyvklRpnlkefleklsklyelhiytmgtraYaeqiakilDpekklfserilsrdellda

GNYVKDLSRL-GRELSKVIIVDNSPASYIFHpENAVP
 . .|.|..|  .. | |.|.|.  . . |. || . 
ssktkklkklfptddsmvviiDDredvWnfa.enlik
subfamily_TIM50_pd Subfamily TIM50 145-247 7.5e-29 92.4 In-house 23-125 (126) alignment 
Range on Protein: 145-247
Range on HMM: 23-125/126.0
VLKRPHVDEFLQRMGQLFECVLFTASLAKYADPVADLLDRWGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSPASYIFHPENAVPVQSWFDD
. ||| || ||.....||| |.||.. . .| |. | ||  .. . ||||... .  |. ||||| | |.|||||.||  ..|. ..||||. .. |  .
fkkrPgvdafleqlaelfeivvftseqgltaaplidkldPkqlimyrlfrdatkyvdGehvkdlsklnrdlskvivvdldkksvklqpenalalkkweGn

MTD
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