Gene HDHD2 in Homo sapiens

Synonym: 3110052N05Rik, HEL-S-301, HDHD2

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily LHPP
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP127_AA protein Get Run
HsapP127_AA_7-256 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Chronophin_1 8-237 6.5e-41 131.5 In-house 2-240 (261) alignment 
Range on Protein: 8-237
Range on HMM: 2-240/261.0
KAVLVDLSGTLHIEDAAVPGAQEALKRLRGASVIIRFVTNTTKESKQDLLERLRKLEFD-ISEDEIFTSLTAARSLLERKQVRPM-LLVDDRALP---DF
. ||.|| | |  ...|||||.|....|. |   . |||| ... ...| .||..| .| ....|||.| .||..||......   ...  . |    . 
qlvLlDldGVlikgeeavpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrqqaakakvyvlGeeglrkelre

KGIQTSD-----PNAVVMGLApEHFHYQILNQAFRLLLDGAPLIAIHKARYYKRKDGLALGPGPFVTALEYATDTKATVVGKPEKTFFLEALRGTGCEPE
.|... |     ..|||.|   |.. .. |..| .|. ||| ..|  . ..  ...| | | |  . |.| |......||||||   | |||. .| .||
aGlrlvdepedrveaVvvGyd.eelsfeklaeaialirdgalfvatnrDptvPleeGiaPgtGslaaaveaAsgreplvvGKPepvmfeealekigadpe

EAVMIGDDCRDDVGGAQDVGMLGILVKTGKYRASDEEKIN
|.||.||    |.  ... |.  .|| ||  .... ....
etvmvGDRldTDilagaraglstllvltGvseleeaqayk
Hydrolase haloacid dehalogenase-like hydrolase 8-215 5e-07 21.6 Pfam-A 2-213 (215) alignment 
Range on Protein: 8-215
Range on HMM: 2-213/215.0
KAVLVDLSGTLHIEDAAV--PGAQEALKRLRGA---------SVIIRFVTNTTKE-----------------------SKQDLLERLRKLEfdISEDEIF
|.|. |. |||     .|  .|...||. .. .         . .... .. . .                       ........| . .  |. |.. 
ktvvfDktGTLtegepsvallgnkaalalaaaletgsehpigkavvaaakanstrggltgfatfigrgvsgkvdgivlgnpewmtalglrv..iapdlva

TSLtaarsllERKQ-------VrpmllvddralpdfkgiqtsdpnaVVMGLAPEHFHYQILNQAFRLLLD----GAPLIAIH-----KARYYKRKDGLal
..        ..|.       |                         .  |.  .|. ..   |  ..      |  .  .       |.   .  |.  
aeg.......qskgrtvvvvav........................qaralgviafadpvkpeaaeavasLkeaGievvlltgdnpetaeaiakqagi..

gPGPFVTALEYatdtkatvvGKPEKTFFLEALRGTGCEPEEAVMIGDDCrDDVGGAQD
  . .|.|  .         ||||.  |. |..  . .|.|..|.||.   |. ... 
.edslvfaevv.........gkPepklfvaaieeLqidpgevamvGDgv.nDapalaa
Chronophin_2 9-88 3e-09 27.6 In-house 2-83 (282) alignment 
Range on Protein: 9-88
Range on HMM: 2-83/282.0
AVLVDLSGTLHIEDAAVPGAQEALKRLRGASVIIRFVTNTTKESKQDLLERLRKLEF-DISEDEIFTSL-TAARSLLERKQV
.|| |  | .   . ||.|| | ..||  |   . |||| .. ..... ... .| | |. ...||.|   .|. | .  .|
nvlfdcdgviwngekavagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycsaaylrdvadv
subfamily_CUT_pd Subfamily CUT 9-89 4.1e-08 23.1 In-house 20-105 (391) alignment 
Range on Protein: 9-89
Range on HMM: 20-105/391.0
AVLVDLSGTLHIEDAAVPGAQEALKRLRGA----SVIIRFVTNTTKESKQDLLERL-RKLEFDISEDEIFTSLTAARSLLERKQVR
....|. | |  .   .|.|.||||.|        | . |.||..  ....  |.| .||..... |... | .  ..| |. ..|
givlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaeklsekLdvevdadqvllshsPlkllaekydkr
Subfamily.CECR5.protein 9-89 4.3e-08 23.0 In-house 22-107 (393) alignment 
Range on Protein: 9-89
Range on HMM: 22-107/393.0
AVLVDLSGTLHIEDAAVPGAQEALKRLRGA----SVIIRFVTNTTKESKQDLLERL-RKLEFDISEDEIFTSLTAARSLLERKQVR
....|. | |  .   .|.|.||||.|        | . |.||..  ....  |.| .||..... |... | .  ..| |. ..|
givlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaeklsekLdvevdadqvllshsPlkllaekydkr
CECR5_TIGR01456 9-88 7.6e-06 15.5 In-house 40-124 (370) alignment 
Range on Protein: 9-88
Range on HMM: 40-124/370.0
AVLVDLSGTLHIEDAAVPGAQEALKRLRGA----SVIIRFVTNTTKESKQDLLERL-RKLEFDISEDEIFTSLTAARSLLERKQV
....|. | |      ..||..||.||        . . ..||.   |..   | |  .|. ..| . .  | .  ..| .. . 
gfaldiDGvllrGkkpiagaskalrrLvddqGalkiPvllltngGglseraraeelsalLgvevsplqviqshsPykklvnkyek
subfamily_LHPP_pd Subfamily LHPP 10-234 2.3e-105 342.6 In-house 1-227 (227) alignment 
Range on Protein: 10-234
Range on HMM: 1-227/227.0
VLVDLSGTLHIEDAAVPGAQEALKRLRGASVIIRFVTNTTKESKQDLLERLRKLEFDISEDEIFTSLTAARSLLERKQVRPMLLVDDRALPDFKGIQTSD
||.||||.||.||||.|||.||||||| |.| .|||||||||||..|.|||..|.||..|.||||||.|||.||.....||.|||.|.. .||..|.|..
vllDlsGvlhnedaaipgavealkrLrqagvkvrfvtNttkeskralverLirlgfdveeeeiftsleaarqllrerklrpyllveddveedfedidtdk

PNAVVMGLAPEHFHYQILNQAFRLLLD--GAPLIAIHKARYYKRKDGLALGPGPFVTALEYATDTKATVVGKPEKTFFLEALRGTGCEPEEAVMIGDDCR
|||||.|||||.|.|. |||||||||.  .|.||||.|..|||||||||||||.||.||||||..||.|||||...|| .||. .|..||||||||||..
pnavviglapesfeyetlnqafrllleakkakliainkgkyykrkdGlalgpGafvkaleyatgvkaevvGKPsalffekaleelgvdpeeavmiGDdve

DDVGGAQDVGMLGILVKTGKYRASDEE
|||.||...|. |.||||||.|..||.
dDveGAlkaGlrgvlVktGkfrpedek
Hydrolase_6 Haloacid dehalogenase-like hydrolase 10-88 4.3e-21 66.2 Pfam-A 1-80 (101) alignment 
Range on Protein: 10-88
Range on HMM: 1-80/101.0
VLVDLSGTLHIEDAAVPGAQEALKRLRGASVIIRFVTNTTKESKQDLLERLRKLEFDISEDEIFTSLTAARSLLERK-QV
.|.|. |.|. .| |.|||.||||.|| | . . ..|| ...|.......|.||..|..|....|| |||...|... . 
flfDvdGvLwrgdkaipgaaealkalraagkpvvllTNnsskseeeyakkleklgvdvteeqvvtsataaaeylkkrkad
subfamily_PGP_pd Subfamily PGP 10-89 8.6e-14 42.5 In-house 2-82 (279) alignment 
Range on Protein: 10-89
Range on HMM: 2-82/279.0
VLVDLSGTLHIEDAAVPGAQEALKRLRGASVIIRFVTNTTKESKQDLLERLRKLEFD-ISEDEIFTSLTAARSLLERKQVR
||.|  |.| ... |.||| |||..|. .   . ||||   .|...||....|| |. ..|.||..|  |. . |..|. .
vlfDcDGVlWlgetaipgaaealnaLkklgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkqkkfe
subfamily_PGP_pd Subfamily PGP 108-251 1.2e-18 58.5 In-house 128-268 (279) alignment 
Range on Protein: 108-251
Range on HMM: 128-268/279.0
SDPNAVVMGLApEHFHYQILNQAFRLLLD-GAPLIAIHKARYYKRKDGLA-LGPGPFVTALEYATDTKATVVGKPEKTFFLEALRGTGCEPEEAVMIGDD
.| .|||.|.  |...|. | .| . | .  . ..|  . . .. |...   |.|..| |.| |.. |..|.|||..  .   |. .  .|| ..|||| 
kdvgAVvvgvd.eklsyakllkAanyLrepevlflatneDallplkkevvipgaGslvaaieaasgrkplvlGKPnelllelllekeeidpertlmiGDr

CRDDVGGAQDVGMLGILVKTGKYRASDEEKINPPPyltcESFPHAV
 . |.  ... |.  .|| .| .. .| |.|.       .  |...
lktDilfgkncGlqtLlvlsGvtkledveeikkee....klvPdyy
Chronophin_2 108-227 6.2e-11 33.1 In-house 124-244 (282) alignment 
Range on Protein: 108-227
Range on HMM: 124-244/282.0
SDPNAVVMGLApEHFHYQILNQAFRLLLDGAPL-IAIHKARYYKRKDGLA-LGPGPFVTALEYATDTKATVVGKPEKTFFLEALRGTGCEPEEAVMIGDD
 | .||..|   |.. .  | .|   | |   | .|  .  ..  .||    | | . .||| |.  ||||.||| . .|         .| ...|||| 
pdvravlvgyd.ekltflklakacaylrdadclllatdrdpwhplsdgritpgsgsltaaletasgrkatvigkpsrfmfecissqfsvdparslmigdr

CRDDVGGAQDVGMLGILVKTGK
 . |.   .. |.  .|  || 
letdilfgsncglstvltltgv
HAD_2 Haloacid dehalogenase-like hydrolase 176-223 1e-08 27.0 Pfam-A 130-176 (176) alignment 
Range on Protein: 176-223
Range on HMM: 130-176/176.0
VVGKPEKTFFLEALRGTGCEPEEAVMIGDDCrDDVGGAQDVGMLGILV
 . ||.. ..  .|. .|. |||...|.|   .|| .|...|. ...|
gapKpdpeayekvlerlgvkpeeilfidDsl.edveaAraaGirtvhv
Hydrolase_like HAD-hyrolase-like 177-246 4.5e-18 56.3 Pfam-A 2-71 (75) alignment 
Range on Protein: 177-246
Range on HMM: 2-71/75.0
VGKPEKTFFLEALRGTGCEPEEAVMIGDDCRDDVGGAQDVGMLGILVKTGKYRASDEEKINPPPYLTCES
 |||..... .||.  |..|.|.|||||.  .|. .|. .|.  |||.|| .|. | ..  . |  ....
lgKPnpgmydkalevlgappsevvmiGDslatDieaAnnaGirsilVltGvsreedlklakakpdyvvdd
CECR5_TIGR01456 200-256 4.5e-08 22.9 In-house 305-360 (370) alignment 
Range on Protein: 200-256
Range on HMM: 305-360/370.0
VMIGDDCRDDVGGAQDVGMLGILVKTGKYRASDEEKINpPPYLTCESFPHAVDHILQ
 |.||.   |. ||...|.  |||||| |  .|| |   .. |  .|  .||..||.
ymvGDnPasDiiGarnaGlfsilvktgvydgadelkeg.karlvvdsvseavikiLe