Gene CIN in Homo sapiens

Synonym: CIN, PLP, dJ37E16.5, RP1-37E16.5, PDXP

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily PGP
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP129_AA protein Get Run
HsapP129_AA_18-296 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Chronophin_2 20-296 3e-144 470.5 In-house 1-282 (282) alignment 
Range on Protein: 20-296
Range on HMM: 1-282/282.0
QGVLFDCDGVLWNGERAVPGAPELLERLARAGKAALFVSNNSRRARPELALRFARLGFGGLRAEQLFSSALCAARLLRQrlpgPPDAPGAVFVLGGEGLR
..||||||||.||||.||.||||...|||||||  |||.|||.|||....|.|||||| ...|||.||||.|.|..||.    ..|. |.|||.||||||
dnvlfdcdgviwngekavagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadvaaeqifssaycsaaylrd....vadvrgkvfviggeglr

AELRAAGLRLAGDPSAG------DGAAPRVRAVLVGYDEHFSFAKLREACAHLRDPECLLVATDRDPWHPLSDGSRTPGTGSLAAAVETASGRQALVVGK
.|||.||.....|..         . .|.||||||||||...| || .|||.|||..|||.|||||||||||||..|||.|||.||.||||||.|.|.||
kelreagvpvvedadeqeasiydcaldpdvravlvgydekltflklakacaylrdadclllatdrdpwhplsdgritpgsgsltaaletasgrkatvigk

PSPYMFECITENFSIDPARTLMVGDRLETDILFGHRCGMTTVLTLTGVSRLEEAQAYLA---AGQHDLVPHYYVESIADLTEGLED
||..|||||...||.||||.||.|||||||||||..||..|||||||||.|||||.|.    |.|.||||.|.||||||| |.||.
psrfmfecissqfsvdparslmigdrletdilfgsncglstvltltgvssleeaqeysdsqlaeqrdlvpdyvvesiadllealee
Chronophin_1 20-295 1.3e-119 389.4 In-house 2-260 (261) alignment 
Range on Protein: 20-295
Range on HMM: 2-260/261.0
QGVLFDCDGVLWNGERAVPGAPELLERLARAGKAALFVSNNSRRARPELALRFARLGFGGLRAEQLFSSALCAARLLRQrlpgpPDAPGAVFVLGGEGLR
| ||.|.||||..||.|||||.||.|.|..|||..|||.|||||.|.||| |..|||. ...||..|||||.||.||||     ..| ..|.|||.||||
qlvLlDldGVlikgeeavpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldavaaeeifssalaaaallrq.....qaakakvyvlGeeglr

AELRAAGLRLAGDPSAgdgaapRVRAVLVGYDEHFSFAKLREACAHLRDPeCLLVATDRDPWHPLSDGsRTPGTGSLAAAVETASGRQALVVGKPSPYMF
.|||.|||||...|..      ||.||.|||||..||.||.||.|..||. .|.|||.|||..||..| ..|||||||||||.||||..||||||.|.||
kelreaGlrlvdeped......rveaVvvGydeelsfeklaeaialirdg.alfvatnrDptvPleeG.iaPgtGslaaaveaAsgreplvvGKPepvmf

ECITENFSIDPARTLMVGDRLETDILFGHRCGMTTVLTLTGVSRLEEAQAYLaagqHDLVPHYYVESIADLTEGLE
|...|....||..|.||||||.||||.|.|.|..|.|.|||||.|||||||.    .||.|...|||||||.| ||
eealekigadpeetvmvGDRldTDilagaraglstllvltGvseleeaqayk....kdlrPdavvesiadlleele
CECR5_TIGR01456 20-51 1.7e-06 17.7 In-house 39-71 (370) alignment 
Range on Protein: 20-51
Range on HMM: 39-71/370.0
QGVLFDCDGVLWNGERAVPGAPELLERLARA-G
 |...| ||||  |.. ..||.. | || .  |
fgfaldiDGvllrGkkpiagaskalrrLvddqG
Hydrolase haloacid dehalogenase-like hydrolase 21-251 1.3e-16 53.0 Pfam-A 3-215 (215) alignment 
Range on Protein: 21-251
Range on HMM: 3-215/215.0
GVLFDCDGVLWNGERAV--PGAPELLERLARA--------GKAALFVSNNSRRArPElaL----RFARLGFGGLRAEQlfssalcaarllrqrlpgppda
 |.||..|.|..||..|  .|. ..|. .|..        |||  ... ..    .   |     |.  | .| . ..                      
tvvfDktGTLtegepsvallgnkaalalaaaletgsehpigkavvaaakanstr.gg..ltgfatfigrgvsgkvdgi......................

pgavfVLggeGLRAELRAAGLR-L--------------------AgdpsagdgaapRVRAVLVGYDEHFSFAKLREACAHLRDPEC-LLVATdRDPWHPL
     ||   | .  ..| ||| .                                 .||. |  ..     ...||.|.|..  . . ..|  |  .. 
.....vl...gnpewmtalglrviapdlvaaegqskgrtvvvvav...........qaralgviafadpvkpeaaeavasLkeaGievvllt.gdnpeta

SDGSRTPGT-GSLAAAVETasgrqalvvGKPSPYMFECITENFSIDPARTLMVGDRLeTDILFGHRCG
.   . .|  .||  |  .         |||.| .|. . | . ||| ...||||.. .|. .. ..|
eaiakqagiedslvfaevv.........gkPepklfvaaieeLqidpgevamvGDgv.nDapalaaAg
subfamily_PGP_pd Subfamily PGP 22-292 4.6e-96 312.4 In-house 2-277 (279) alignment 
Range on Protein: 22-292
Range on HMM: 2-277/279.0
VLFDCDGVLWNGERAVPGAPELLERLARAGKAALFVSNNSRRARPELALRFARLGFGGLRAEQLFSSALCAARLLRQrlpgpPDAPGAVFVLGGEGLRAE
||||||||||.||.|.|||.|.|..|...|| .|||.||| ..| ||. .|..|||  .. |...||| ..|. |.|         . |.||| |||..|
vlfDcDGVlWlgetaipgaaealnaLkklgKkvlfvtNnstksreellkkfkklgfekvkeeeilssaaaiadyLkq.....kkfekkvyvlgeeglkee

LRAAGLRLAG-DPSAGDGAAP-----------RVRAVLVGYDEHFSFAKLREACAHLRDPECLLVATDRDPWHPLSDGSRTPGTGSLAAAVETASGRQAL
|..||..|.| .|.  ....            .|.||.||.||..|.||| .|...||.||.|..||..| ..||... ..||.|||.||.|.||||..|
LkeagiellgtgpeklkdeldedfveelkldkdvgAVvvgvdeklsyakllkAanyLrepevlflatneDallplkkevvipgaGslvaaieaasgrkpl

VVGKPSPYMFECITENFSIDPARTLMVGDRLETDILFGHRCGMTTVLTLTGVSRLEEAQAYLAAGqhDLVPHYYVESIADLTE
|.|||.....|...|...||| ||||.||||.||||||..||..|.| |.||..||..... ...  .|||.||..|.|||.|
vlGKPnelllelllekeeidpertlmiGDrlktDilfgkncGlqtLlvlsGvtkledveeikkee..klvPdyyldsladlle
subfamily_LHPP_pd Subfamily LHPP 22-265 5.5e-34 109.1 In-house 1-224 (227) alignment 
Range on Protein: 22-265
Range on HMM: 1-224/227.0
VLFDCDGVLWNGERAVPGAPELLERLARAGKAALFVSNNSRRARPELALRFARLGFGgLRAEQLFSSALCAARLLRQRLPgppdapgAVFVLGGEGLRAE
|| |  |||.|.. |.||| | |.|| .||.   ||.|...... .|. |  ||||. ...|..|.|.  |..|||.|           ..|  .. . .
vllDlsGvlhnedaaipgavealkrLrqagvkvrfvtNttkeskralverLirlgfd.veeeeiftsleaarqllrerkl.......rpyllveddveed

LraAGLRlAGDPsagdgaaprvRAVLVGY-DEHFSFAKLREACAHLRD-PECLLVATDRDPWHPLSDGsRTPGTGSLAAAVETASGRQALVVGKPSPYMF
.  ...    .|           || .|  .|.|....| .|   | . ..  |.| ... ..  .||  . | |. ..|.| | | .| ||||||...|
f..edid.tdkp..........navviglapesfeyetlnqafrllleakkakliainkgkyykrkdG.lalgpGafvkaleyatgvkaevvGKPsalff

ECITENFSIDPARTLMVGDRLETDILFGHRCGMTTVLTLTGVSRLE
|   |....||.. .|.|| .| |.    ..|. .||  ||. | |
ekaleelgvdpeeavmiGDdvedDveGAlkaGlrgvlVktGkfrpe
Hydrolase_6 Haloacid dehalogenase-like hydrolase 22-127 1.7e-28 90.0 Pfam-A 1-100 (101) alignment 
Range on Protein: 22-127
Range on HMM: 1-100/101.0
VLFDCDGVLWNGERAVPGAPELLERLARAGKAALFVSNNSRRARPELALRFARLGFGgLRAEQLFSSALCAARLLRQRLPgppdaPGAVFVLGGEGLRAE
.|||.|||||.|..|.|||.|.|..| .|||  ....|||.. . |.| .. .||.  . .||...|| .||..|..| .      . |.|.|.||||.|
flfDvdGvLwrgdkaipgaaealkalraagkpvvllTNnsskseeeyakkleklgvd.vteeqvvtsataaaeylkkrka.....dkkvlvigeeglree

LRAAGL
|..||.
lkeaGf
PGP_phosphatase Mitochondrial PGP phosphatase 187-261 3.7e-06 16.5 Pfam-A 88-167 (168) alignment 
Range on Protein: 187-261
Range on HMM: 88-167/168.0
GSRTPGTGSLAAAVETASGRQALVVGKPSPYMFECITENFSID-----PARTLMVGDRLETDILFGHRCGMTTVLTLTGV
||.   ... |.|.| ..| . |   .  |   | ..| |. .     .   ..||||| ||.|.... | . |..  ||
GssddkdaekaealekslgipVlrhkekKPgcaeevleyfkekkvvtkadeiavvgDRllTdvlmanmmGslsvwlregv
HAD_2 Haloacid dehalogenase-like hydrolase 210-256 5e-08 24.7 Pfam-A 130-175 (176) alignment 
Range on Protein: 210-256
Range on HMM: 130-175/176.0
VVGKPSPYMFECITENFSIDPARTLMVGDRLeTDILFGHRCGMTTVL
 . ||.| ..| . | . ..| ..|...|.|  |.  .. .|. ||.
gapKpdpeayekvlerlgvkpeeilfidDsl.edveaAraaGirtvh
Hydrolase_like HAD-hyrolase-like 211-290 8.6e-22 68.2 Pfam-A 2-75 (75) alignment 
Range on Protein: 211-290
Range on HMM: 2-75/75.0
VGKPSPYMFECITENFSIDPARTLMVGDRLETDILFGHRCGMTTVLTLTGVSRLEEAQAylaagQ-HdlVPHYYVESIADL
 |||.| |.. . | ....|....|.||.|.|||......|....|.|||||| |....       .   |.|.|......
lgKPnpgmydkalevlgappsevvmiGDslatDieaAnnaGirsilVltGvsreedlkl.....aka..kpdyvvddleea