Gene PGP in Homo sapiens

Synonym: PGPase, PGP

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HAD
Superfamily HAD
Family NagD
Subfamily PGP
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP130_AA protein Get Run
HsapP130_AA_28-320 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Hydrolase haloacid dehalogenase-like hydrolase 28-271 1.4e-18 59.4 Pfam-A 1-213 (215) alignment 
Range on Protein: 28-271
Range on HMM: 1-213/215.0
VDTLLFDCDGVLWRGETAV--PGAPEALRALRAR--------GKRLGFITNNSSKTraayaEKlrRLGFGGPAGPGASLEVFGTayctalylrqrlagap
..|..||..|.|. || .|  .|. .||....|         || . ... ..|       .     ||   .| |.|  | |                 
iktvvfDktGTLtegepsvallgnkaalalaaaletgsehpigkavvaaakanstr.....gg..ltgfatfigrgvsgkvdgi................

apkayVLGSPALAAELEAVGvASVGVGPEPLQGEGPGDWLHAPlepDVRAVVVGFDPHFSYMKLTKALRYLQQPGC-LLVGTnMDNRLPLENGRFIAGT-
     ||| | ....|.. .  .. .. .  | .|  .   |    ..||. |  .    . .. .|...|.. |. . . |  ||. . |.    ||  
.....vlgnpewmtalglrv.iapdlvaaegqskgrtvvvvav...qaralgviafadpvkpeaaeavasLkeaGievvllt.gdnpetaeaiakqagie

-GCLVRAVEmaaqrqadiiGKPSRFIFDCVSQEYGINPERTVMVGDRLdTDILLGAT
  . .  |           |||.  .|  . .|..|.|....||||.. .|.  .| 
dslvfaevv..........gkPepklfvaaieeLqidpgevamvGDgv.nDapalaa
Chronophin_1 29-317 3.3e-84 273.4 In-house 2-257 (261) alignment 
Range on Protein: 29-317
Range on HMM: 2-257/261.0
DTLLFDCDGVLWRGETAVPGAPEALRALRARGKRLGFITNNSSKTRAAYAEKLRRLGFGGPagpgASLEVFGTAYCTALYLRQrlaGAPAPKAYVLGSPA
...|.|.||||..||.|||||.|...||. .||.. |.||||..||. .|..|.|||. .     |. |.| .|...| .|||    |   |.||||.  
qlvLlDldGVlikgeeavpgAaeliealkqagkevlfvtNnsrrtreelaarlkrlGldav....aaeeifssalaaaallrq...qaakakvyvlGeeg

LAAELEAVGVASVGvGPEPlqgegpgdwlhaplepDVRAVVVGFDPHFSYMKLTKALRYLQQPgCLLVGTNMDNRLPLENGrFIAGTGCLVRAVEMAAQR
| .||.. |.  |. .||.                .|.|||||.|...|..||..| ...... .|.| || |   |||.|  . ||| |..||| |..|
lrkelreaGlrlvd.eped................rveaVvvGydeelsfeklaeaialirdg.alfvatnrDptvPleeG.iaPgtGslaaaveaAsgr

QADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGATCGLKTILTLTGVSTLGDVKNNQesdcvskKKMVPDFYVDSIADLLP
.. ..|||....|...... |..||.||||||||||||| || .||.|.|.|||||.| .... .       |...||..|.|||||| 
eplvvGKPepvmfeealekigadpeetvmvGDRldTDilagaraglstllvltGvseleeaqayk.......kdlrPdavvesiadlle
CECR5_TIGR01456 29-60 1.5e-07 21.1 In-house 39-71 (370) alignment 
Range on Protein: 29-60
Range on HMM: 39-71/370.0
DTLLFDCDGVLWRGETAVPGAPEALRALRAR-G
 ....| |||| ||.  ..||..||| |    |
fgfaldiDGvllrGkkpiagaskalrrLvddqG
Chronophin_2 30-320 7.4e-96 311.7 In-house 2-281 (282) alignment 
Range on Protein: 30-320
Range on HMM: 2-281/282.0
TLLFDCDGVLWRGETAVPGAPEALRALRARGKRLGFITNNSSKTRAAYAEKLRRLGFGGPagpgASLEVFGTAYCTALYLRQrlAGAPAPKAYVLGSPAL
..|||||||.| ||.||.|||| .. |  .||.  |.||||...|  |..|. |||| .     |  ..| .|||.|.|||.  .     | .|.|.  |
nvlfdcdgviwngekavagapevvsrlaragknvlfvtnnstrarenyvlkfarlgfadv....aaeqifssaycsaaylrd..vadvrgkvfviggegl

AAELEAVGVASVGVGPEPLqgegpGDWLHAPLEPDVRAVVVGFDPHFSYMKLTKALRYLQQPGCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQRQ
 .||.. ||  |.   |.         ....|.||||||.||.| .....||.||  ||... |||. |. |   ||..|| . |.| |  |.|.|. |.
rkelreagvpvvedadeqe.....asiydcaldpdvravlvgydekltflklakacaylrdadclllatdrdpwhplsdgritpgsgsltaaletasgrk

ADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGATCGLKTILTLTGVSTLGDVKNNQESDCVSKKKMVPDFYVDSIADLLPALQ
| .|||||||.|.|.|... ..| |..|.||||.||||.|  |||.|.|||||||.| . .. ..|.  .....|||..|.||||||.||.
atvigkpsrfmfecissqfsvdparslmigdrletdilfgsncglstvltltgvssleeaqeysdsqlaeqrdlvpdyvvesiadlleale
subfamily_PGP_pd Subfamily PGP 30-318 2.8e-94 306.5 In-house 1-278 (279) alignment 
Range on Protein: 30-318
Range on HMM: 1-278/279.0
TLLFDCDGVLWRGETAVPGAPEALRALRARGKRLGFITNNSSKTRAAYAEKLRRLGFGgpagPGASLEVFGTAYCTALYLRQrlaGAPAPKAYVLGSPAL
|.|||||||||.||||.|||.||| ||.. ||.. |.|||| |.|. ...|...|||        . |.. .|...| ||.|        | ||||. .|
tvlfDcDGVlWlgetaipgaaealnaLkklgKkvlfvtNnstksreellkkfkklgfe....kvkeeeilssaaaiadyLkq...kkfekkvyvlgeegl

AAELEAVGVASVGVGPEPLQGEGP-GDWLHAPLEPDVRAVVVGFDPHFSYMKLTKALRYLQQPGCLLVGTNMDNRLPLENGRFIAGTGCLVRAVEMAAQR
..||...|. ..| ||| |..|     . .  |..||.|||||.| ..||.||.|| .||..| .|...|| |. |||.... |.|.| ||.|.|.|..|
keeLkeagiellgtgpeklkdeldedfveelkldkdvgAVvvgvdeklsyakllkAanyLrepevlflatneDallplkkevvipgaGslvaaieaasgr

QADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGATCGLKTILTLTGVSTLGDVKNNQESDcvskkKMVPDFYVDSIADLLPA
.. ..|||........ ... |.||||.|.||||.||||.| .|||.|.| |.||..| ||.......     |.|||.|.||.||||. 
kplvlGKPnelllelllekeeidpertlmiGDrlktDilfgkncGlqtLlvlsGvtkledveeikkee.....klvPdyyldsladllel
subfamily_CUT_pd Subfamily CUT 30-81 2.2e-07 20.7 In-house 20-75 (391) alignment 
Range on Protein: 30-81
Range on HMM: 20-75/391.0
TLLFDCDGVLWRGETAVPGAPEALRALRARGKR----LGFITNNSSKTRAAYAEKL
....| |||| ||.  .|.| |||. |  .  .      |.||..  |  . ||||
givlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaekl
Subfamily.CECR5.protein 30-81 2.4e-07 20.6 In-house 22-77 (393) alignment 
Range on Protein: 30-81
Range on HMM: 22-77/393.0
TLLFDCDGVLWRGETAVPGAPEALRALRARGKR----LGFITNNSSKTRAAYAEKL
....| |||| ||.  .|.| |||. |  .  .      |.||..  |  . ||||
givlDiDGvLlRgkkvipaakealklledkkgelkvPvvfltnggnftekekaekl
Hydrolase_6 Haloacid dehalogenase-like hydrolase 31-138 5e-30 94.9 Pfam-A 1-100 (101) alignment 
Range on Protein: 31-138
Range on HMM: 1-100/101.0
LLFDCDGVLWRGETAVPGAPEALRALRARGKRLGFITNNSSKTRAAYAEKLRRLGFGgpagpGASLEVFGTAYCTALYLRQRlagAPAPKAYVLGSPALA
.|||.|||||||..|.|||.|||.||||.||.. ..||||||....||.||..||.       .  .|. .|...| ||..|    .  |..|.|. .|.
flfDvdGvLwrgdkaipgaaealkalraagkpvvllTNnsskseeeyakkleklgvd.....vteeqvvtsataaaeylkkr...kadkkvlvigeeglr

AELEAVGV
.||...|.
eelkeaGf
subfamily_LHPP_pd Subfamily LHPP 32-283 7.4e-35 111.9 In-house 2-220 (227) alignment 
Range on Protein: 32-283
Range on HMM: 2-220/227.0
LFDCDGVLWRGETAVPGAPEALRALRARGKRLGFITNNSSKTRAAYAEKLRRLGFGGpagpgASLEVFGTAYCTALYLRQRLAgapapKAYVLGSPALAA
| |  |||. ...|.||| |||. ||..|... |.||.. ....| .|.|.||||.         |.| ..  .. .||.|       . |.| ...   
llDlsGvlhnedaaipgavealkrLrqagvkvrfvtNttkeskralverLirlgfdv.....eeeeiftsleaarqllrerkl.....rpyllveddvee

ELEAVGVASVgvgpeplqgegpgdwlhaplepdvRAVVVGFDP-HFSYMKLTKALRYLQQ-PGCLLVGTNMDNRLPLENGrFIAGTGCLVRAVEMAAQRQ
..|..  ..                          |||.|  | .|.| .|..| | | . ..  |.  | .     ..|  . | |. |.|.| |.. .
dfedidtdkp........................navviglapesfeyetlnqafrllleakkakliainkgkyykrkdG.lalgpGafvkaleyatgvk

ADIIGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGATCGLKTILTLTGV
| ..||||...|. . .| |..||. ||.|| .  |.    ..||...|  ||.
aevvGKPsalffekaleelgvdpeeavmiGDdvedDveGAlkaGlrgvlVktGk
HAD_2 Haloacid dehalogenase-like hydrolase 184-278 4.6e-07 21.6 Pfam-A 85-175 (176) alignment 
Range on Protein: 184-278
Range on HMM: 85-175/176.0
ALRYLQQPGCLLVG-TNMDNRLPLENGRFIAGTgCLVRAVEMAAQRQAdiiGKPSRFIFDCVSQEYGINPERTVMVGDRLdTDILLGATCGLKTIL
.||.|.. |. ||  .|....   .. .       |..||  . . .|    ||.  ... | ...|..||......|.|  |.  .  .|..|..
llrrlkakgvklvilSngsaeavkllleklgle.dlfdavftsddvga...pKpdpeayekvlerlgvkpeeilfidDsl.edveaAraaGirtvh
Hydrolase_like HAD-hyrolase-like 233-315 7.2e-19 58.9 Pfam-A 2-75 (75) alignment 
Range on Protein: 233-315
Range on HMM: 2-75/75.0
IGKPSRFIFDCVSQEYGINPERTVMVGDRLDTDILLGATCGLKTILTLTGVSTLGDVKNnqesdcvskKKMVPDFYVDSIADL
.|||.....|   ...|..|...||.||.|.|||. .  .|...||.|||||. .| |          .|  ||..||.....
lgKPnpgmydkalevlgappsevvmiGDslatDieaAnnaGirsilVltGvsreedlkl.........akakpdyvvddleea