Gene PXYLP1 in Homo sapiens

Synonym: ACPL2, HEL124, XYLP, UNQ370/PRO706, PXYLP1

Gene expression: GTEx, DEPOD

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold HP
Superfamily HP
Family HP2
Subfamily PXYLP1
Protein sequence
ID Type Fasta BLAST phosphatome Note
HsapP166_AA protein Get Run
HsapP166_AA_46-477 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0047369 Phosphoglycerate mutase-like 47-476 6.9e-72 235.9 In-house 5-437 (438) alignment 
Range on Protein: 47-476
Range on HMM: 5-437/438.0
IMPDPVTEPPVTDPVYEALLYCNIPSVAERSMEghAPHHFKLVSVHVFIRHGDRYPLYVIPKTKRPEIDCtlVANRKPYHPkleafishmskgsgasfes
..|  .......  ..   .|...|.|   |..  .|....|. |.|..|||.|.|.. ..|. .|....  . | ..|..                   
lapvlsvdfnillhlgtlspyfsapgvglisld..vpegcelkqvqvlfRHGaRtPtksklkkleplwel..lenattyps...................

plNSLPLYPNH-PLCEMGELTQTGVVQHLQNGQLLRDIYlkkhKLLpndwSADQL-YLETTGKSRTLQSGLALLYGFLPDFDWK--------KIYFRHQP
  ..|. .... . | .|.||..|..|. . |. ||..|    .||    . ... |. .... |||||. |.|.|..|.  ..         | . ..|
..gplsflndwlgpcgagqLTplGreqayelGkrlrkrY....glL....npedvlyvrssdvdRtlqSAqaflaGlfppegtgelapilwqpipihtip

---SALFCS-GSCYCPVRNQYLEKEQRRQYLLRLKNSQLEKTYGEMAKIVDVPTKQLRAANPIDSM-LCHFCHNVSFPCTRNGCVDMEHFKVIKthQIED
   . |... .|..|| ....|.. . ..  |.|..... |.. ............. . . . .. .......  ...   .....|...|..  ...|
esddfllnllpsdscpafdellkeflasdeflelllkdilkrlkkllpglnltpsdvldlydlcaydtlangyaglplspfcslftpeelevle..ylad

ERERREKKLYFGYSLLGAHPILNQTIGRMQRATEGRK----------------EELFALYSAHDVTLSPVLSALGLSEARF-------------------
..   ..  .. .. | ..|.||... |...| .|.                 .  . ||.|||.|. ..||||||.. ..                   
lefyylygygnelaklaggpllneilarledaingkstnlnltldsngvtfPldlklylyfaHdttiaallsaLglfddtwplpglpldkialnrlfrss

---PrFAARLIFELWQDReKPSEHSVRILYNGVDVTFHtsFCQDhhkrSPKPMCPLENLVRFVKRdmfV-AlgGsgtNYYDACH
   | .|..|.|||.... ...|..||.||||......  .|..    .|  .|||......||.   .    |   .....|.
eivP.yasnlvfElyecp.sdgeyyVrvlyngkvlplp..gcgs....gpgglCplddFkelvkk...llp..g...dfeelCg
0048946 Phosphoglycerate mutase-like 48-477 5.9e-76 249.1 In-house 4-411 (447) alignment 
Range on Protein: 48-477
Range on HMM: 4-411/447.0
MPDPVTEPPVTDPVYEALLYCNIPSVaerSMEGHAPHHFKLVSVHVFIRHGDRYPLYVIPKTKRPEIDCTLVANRKPYHPKLEaFISHMSKGSGASFESP
.|.........  ..    |...|..   ... ..|....|. |.|..|||.|.|.. ..|. .| .|.   ||  .....|. |. .. .  ..... |
gpaladgfnillhlgtlspyfsvpgy...gipepvpegcelkqvqvlfRHGaRtPtkkylkgleplldllknanvlelggdls.flndwkyqlkneplwp

lnslplypnhplCEMGELTQTGVVQHLQNGQLLRDIYlkkHKLLPndwSADQLYLETTGKSRTLQSGLALLYGFLPDF---DWKKIYFRHQPSALFCSGS
            |..|.||..|  |. . |. ||. |   ..|||   . ...|. .....|||||..|.|.|..|.    ... | .  .||  ...  
............cglgqLTplGreqlyelGkrlrkrY...lgllp...npseiyvrssdvdRtlqSaqaflaGlfppepplgyqpipihtvpssndnlll

CYCPVRNqylekEQRRQYLLRLKNSQLEKTYGEMAKIVDVPTKQLR-AANPIDSMLC-HFCHNVSFPCtrnGCVDMEHFKVIktHQIEDERERREKKLYF
..|| ..     |. ...|    . .|....  ..|...  .  |  . . .| .|. ...|. |..|   .....| ..|.  ....| . . |   . 
psCpafk.....ellkkelaeelkellkellerlkkllgglnltlsdvydlydlllyetaihglsplc...slftpeelevl..eyladlefyyeygygd

GYSLLGAHPILNQTIGRMQRATEGRKeeLFALYSAHDVTLSPVLSALGLSEARFPR------------------FAARLIFELWQDREK---PSEHSVRI
 ...| ..|.||. . |...|..|.    . ||.||| |. ..||||||.. . |.                  .|..|.|||......   ..|..||.
elarlaggpllneilarledaisgds..klylyfaHdttiaallsaLglfddelplpadnlpfnrlfrsseivPyasnlvfElyecpsslpsdgeyyVrv

LYNGVDVTFHtsFCQdhhkRSPKPMCPLENLVRFVKRdmfvALGgsgtNYYDACHR
|||| .....  .|.     .|  .|||.......|.    .|.    .....|. 
lyngeplplp..gCg....sgpgglCplddFkellkk....flp....dweklCgl
0049059 Phosphoglycerate mutase-like 52-458 3.7e-75 246.4 In-house 9-424 (435) alignment 
Range on Protein: 52-458
Range on HMM: 9-424/435.0
VTEPPVTDPVYEALLYCNIPSVAERSMegHAPHHFKLVSVHVFIRHGDRYPLYVIPKTKRPEIDCTLVANRKPYhpkleafishmskgsgasfesplNSL
.. .... ...  ..|...|.| . |.  ..|....|. |.|..|||.|.|.. ..|. .. ... | ....|                        ..|
sdgfnillllgtlspyfsapgvfgisl..dvpegcelkqvqvlfRHGaRtPtsklikklealwekllslltypn.......................gpl

PLYPNHP-LCEMGELTQTGVVQHLQNGQLLRDIYlkkHKLlpndWSADQLYLETTGKSRTLQSGLALLYGFLPDF-----------DWKKIYFRHQPSAL
. .....  . .||||..|..|. . |. ||. |   ..|    .. |..|. .... |||||. |.|.|..|.            ..  . .....|  
sflndwnyplgageLTplGreqayelGkrlrkrY...gfL....ynpdevyvrssdvdRtlqSaqaflaGlfppeilgsqllnplnvyqpvpietvdsdn

FCSGSCYCPVRNQYLEKEQRRQYLLRLKNSQLEKTYGEMAKIVDVPTKQLRAANP---IDSMLCHFCHNVSFPCTrnGCVDMEHFKVIKthQIEDERERR
..  ...||  ...|.. .  .  | | ...  | . |............ ...    .|..|.. .|....|..  .....| ..|..  .. | .   
dtlpydscpafdellkellasdeflelflerilkllqellpglgltpsdvldlydlckydtlllgyahglplpfc..slfteeelevle..yladlefyy

EKKLYFGYSLLGAHPILNQTIGRMQRATEGRK----------------EELFALYSAHDVTLSPVLSALGLSEARF----------------------Pr
..  .  .. | ..|.||. . |...| .|..                .  . ||.||| |. |.|||||| . .                       | 
lygygdeiaklaggpllneilarledaingdstnlnltldsnpatfpldlklylyfaHdttiapllsaLglfddqlplpadntpfpeldrlfrtseivP.

FAARLIFELWQDrEKPSEHSVRILYNGVDVTFHtsFCQdhhkRSPKPMCPLENLVRFVKR
.|..|.|||... ....|..||.||||......  .|.     .|. .|||......||.
yasnlvfElyec.pdgneyyVrvlyngkvlplp..gcg....sgpgglCplddFkelvkk
subfamily_PXYLP1_pd Subfamily PXYLP1 66-478 4.6e-208 682.5 In-house 2-419 (419) alignment 
Range on Protein: 66-478
Range on HMM: 2-419/419.0
LYCNIPSVAERSMEGHAPHHFKLVSVHVFIRHGDRYPLYVIPKTKRPEIDCTLVANRKPYHPKLEAFI-SHMSKGSGASFE---SPLNSLPLYPNHPL-C
||||||.|..||.||.....|||..|.|.||||||.||..|||.||.||.|.|.|..|....||..|. ...|..||..||   .||.||||.|||.. |
lycnipdveirseeGkikegfkLkavlvvirhGDrtPlsdipkskraeinCdlsaasknlvdklksfldnssseasgsdfenkvgplkslPllpnheriC

EMGELTQTGVVQHLQNGQLLRDIYLKKHKLL--PNDWSADQLYLETTGKSRTLQSGLALLYGFLPDFDWKKIYFRHQPSALFCSGSCYCP-VRNQYLEKE
|.|.|||.||||||..|.|||..|.||.|||  ||..|.|...||||.|.|||||.||||||.||....|.|..|..||..||.|.|.|| .....||||
elgqLtqkGvvqhLevGdllrkvYakklklLlkpnelssDevvlettrkrrtlqsalallygllpkaklkairvrespsvafClgeCsCPallrkrleke

QRRQYLLRLKNSQLEKTYGEMAKIVDVPTKQLRAANPIDSMLCHFCHNVSFPCTRNGCVDMEHFKVIktHQIEDE-RERREKKLYFGYS-LLGAHPILNQ
...|.|||.|.....|..||..|.....|......||.|..|...|||||.||.|.|||...|..|.  |...|| ..|..||.|...| ||.|.|.|..
adkqlLlrgkvldvmksvgetlkgtilqttlngisnpvdalltvlChnvslPcrreGcvepshvdvl..hkladelsqrsakksyyklsGllraypllrd

TIGRMQRATEGRKEELFALYSAHDVTLSPVLSALGLSEARFPRFAARLIFELWQdREKPSEHSVRILYNGVDVTFHTSFCQDHHKRSPKPMCPLENLVRF
...||....||...|.|.|||.|||||.|...||||||||....|.||.|||.. ||...|...|.||||.|||....||....|||.|..|||||||||
ivsrmlkiieGvdkekfvlysghDvtlrplvaaLglseartiayasrlvfelyr.reaskeyylrvlynGkDvtqkvdfCegdskrskkdlCPlenlvrf

VKRDMFVALggSGTNYYDACHRE
||.|.|.||  |.|||.|||.|.
vkkdyfsal..satnykdaCtrv
subfamily_HP2-Group1_pd Subfamily HP2-Group1 81-224 2.2e-14 44.6 In-house 14-153 (422) alignment 
Range on Protein: 81-224
Range on HMM: 14-153/422.0
HAPHHFKLVSVHVFIRHGDRY-PLYVIP--KTKRPEIDCTLVANRKPYhPKLEAFISHMSKGSGASFespLNSLplYPNHPLCEMGELTQTGVVQHLQNG
  |  .||  |.| ||||||    |  .  .      ||.||  . |   | |     . .     .   ||.     ..  | ...||  |  |.. ||
glpedvklkqvivvirhGdrvraaynGscwdGddaiwdcdlvsaslpv.ikvekerivvdriyrkiy...lntr..eedaGdcavaqltleGykqqelnG

QLLRDIYLKKHKLlPNDWSADQLYLETTGKSRTLQSGLALLYGFLPD
| ||..|...  |  .. .. ..|| .  .|||..|  ||. |. |.
qilrkvyvdtGfl.kssldssevylrsddesrtilsaqalilGmypq
0048439 Phosphoglycerate mutase-like 82-457 1.3e-64 211.9 In-house 3-387 (391) alignment 
Range on Protein: 82-457
Range on HMM: 3-387/391.0
APHHFKLVSVHVFIRHGDRYPLYVIPKTKRPEIDCtlvanrkpyhpkleafishmskgsgasfesplnslpLYPNHPlCEMGELTQTGVVQHLQNGQLLR
 |.. .|. |.|..|||.|.|.. .|.  .| ...                                    |.||.| | .||||..|. |. . |. ||
vpagcelkqvqvlfRHGaRtPtssypnkldpllnk....................................llpngp.cglgeLTplGreqlyelGrrlr

DIYLKkHKLLPNDW--SADQLYLETTGKSRTLQSGLALLYGFLPDFDWKKIYFRHQ---PSALFCSGSCYCPVRNQYLEKEQRRQYLLRLKNSQLEKTYG
. | . ..|||...  . ...|. .... |||||. |.|.|..|. ... |.       .. |.    ..||  ...| .......   .....||. . 
krYvd.lgllpskytlnpsevyvrssdvdRtlqSAqaflaGlfpplgltvilvivvesedpllnplpintcplledlllldalsalprfylseilerlae

EMAKIVDV--P-------------------------TKQLRAANPIDSMLCHFCHNVSFPCT-RNGCVDMEHFKVIKTHQIEDERERREKKlyfGYSLLG
.. .....                            .    . .  | .|.. .|. ..|.   ......|..|..  ...| .      .    .. | 
vlnrvlglnltaedvlslfdlcaketaalgsllklssplcdlftlydtllyeyahglplpewltdellspellkqladlvnelyyyltgsg...eiakla

AHPILNQTIGRMqrATEGRKEELFALYSAHDVTLSPVLSALGLSEA------RFPRFAARLIFELWQDrEKPSEHSVRILYNGVDV--------------
. |.||... ..  ...| ..  . ||.||| |. ..|||||| .        .| .|..|.|||... ....|..||.|||| ..              
ggpllneilddl..vangpsdpklylyfaHdttiaallsaLglfndtlplpadlppyasnlvfElyec.psdgeyyVrvlynggtldlprdltlldldef

----TFHTSFCQDhhkrSPKPMCPLENLVRFVK
    . . ..|..    .|  .|||...|..||
llrlvlplpgcgs....gpgglCplddFvelvk
0046349 Phosphoglycerate mutase-like 83-461 1.4e-63 208.5 In-house 3-404 (409) alignment 
Range on Protein: 83-461
Range on HMM: 3-404/409.0
PhHFKLVSVHVFIRHGDRYPLYVipktkrpeidctlvanrkpyhpkleafishmskgsgasfesplnsLPLYPNHPL-------CEMGELTQTGVVQHLQ
| . .|. |.|..|||.|.|..                                              |...||.|.       | .|.||..|..|. .
P.gceLkqvqvlfRHGaRtPtkk.............................................lsflpnwpginwtngpcgagqLTplGreqaye

NGQLLRDIYLKkHKLLPND--WSADQLYLETTGKSRTLQSGLALLYGFLPDFDWK---------------KIYFRHQP-------SALFCSGSCYCPVRN
 |. ||. | . ..|||.   .. |..|. .... |||||. |.|.|..|. ...               .|    .|       .. .. . ..||  .
lGkrlrkrYvd.lgLlpsnslynpdeiyvrssdvdRtlqSAqaflaGlfpplggeivpllrqdlldppfqpipidtvpiseddalddtllppdslcpald

QYLEKEQRR-QYLLRL----------KNSQLEKTYGEMAKIV-----DVP-TKQLRAAN-PIDSMLCHFCHNVSFPcTRNGCVDMEHFKVIKThqIEDER
..|.. .   .  |.           .....  .. ..|...     ... |. |..|.  .| .|.. .|. ..|    .....|..||.    . |  
kllkenlkslsevleflvdealldlelldetkdllkklaerlnselpglnltdpldvasllydtllyetahglplp.pwcdlftpeelkvlay..ladle

ERREKKLYfGYSLLGAHPILNQTIGRMQRATEGRK------EELFALYSAHDVTLSPVLSALGLSE-----ARFPRFAARLIFELWQDrEKPSEHSVRIL
   . .    .. | . |.||. . |...|..|.       .  . ||.|||.|. ..||||||..      ..| .|..|.|||...  ...|..||.|
yyylygsg.elaklaggpllneilarledaisgknpvtfpldlklylyfaHdttiaallsaLglfdrlfrssdippyasnlvfElyec.psdgeyyVrvl

YNGVDVTF---------------HTSFCQDHHKRSPKPMCPLENLVRFVKRDMF
|||  ...               .... .... .. . .||||. .|||.. ..
ynggplplpgcgegcplsefkellkkrlpgcgltdfdklCpledflrfvdkail
subfamily_ACP2_pd Subfamily ACP2 83-458 1.5e-49 161.4 In-house 4-346 (361) alignment 
Range on Protein: 83-458
Range on HMM: 4-346/361.0
PHHFKLVSVHVFIRHGDRYPLYVIPKTKrpeidctlvanrkpyhpkleafishmskgsgasfesplnslplY-----PNhplcEMGELTQTGVVQHLQNG
... || .|.| .||||| ||   |..|                                           |     |.     .|.||. |. |... |
seerkLkfvqvlfRHGdRsPlntypndk...........................................ykedewpq....glGqLTeeGmqqqyeLG

QLLRDIYLKKHKLLPNDWSADQLYLETTGKSRTLQSGLALLYGFLPD---F------DWKKIY--FRHQPSALFCSGSCYCPVRNQYLEKEQRRQYLLrL
..||. |....|.|... ...|.|. .. . |||.|  ..|.|..|.          .|...    ... . | .. .. ||.... |.. . .. .   
kfLrkrYvedtkfldakynpkqiyvrSsdvnRTlmSaqsvlaglfppetgvdypdeqeWqpvPvhtvseeedlllrakknCprydellqeakespevk.k

KNSQLEKTYGEMAKIVDVPTKQLRAANPIDSMLCHFC-HN-VSFPCTRNGCVdMEHFKVIKTHQIEDERERREK--KlyfGYSLLGAHPILNQTIGRMQR
.... .. . .. .  . .... . ..  |...|.   .| ...|   |  . .|. . ... . | | .  ..  .    .. | . |.||. . .|..
lleenkelleklsestgedidlenfyqlsdtlicerkyanelnlpewandel.fekleeladkvkeaefglnnektr...elkklrgGpllnellenmke

ATE---GRKEELFALYSAHDVTLSPVLSALGLSEARFPRFAARLIFELWQDreKPSEHSVRILYNGVDVTFHT----SFCQDhHKRspkpmCPLENLVRF
...    .|.. . |||||| || ..|.|||. | . |..|...|.||...  .  .. |..||.  . .  .    ..|..  ..     |||... ..
klkceekkkklklflYSaHDttlaalLeaLgifekkappyasaiivElyee..ddgkplvkvlyrnetskdppeltlpgCkg.eed.....Cplskfkki

VKR
|| 
vkp
subfamily_ACP6_pd Subfamily ACP6 86-430 1.3e-32 104.9 In-house 2-341 (376) alignment 
Range on Protein: 86-430
Range on HMM: 2-341/376.0
FKLVSVHVFIRHGDRYPLYVIPKTKRPEIDCTLVANrKPyHPKLEAFISHMSkGSgASFESPLN-SLPLYPNHPLCEMGELTQTGVVQHLQNGQLLRDIY
..|. | |. ||| | |.. .|...  | |  |. .  | . ...  ....  |     ||...      . .  . .|.||..|  |  . |. ||  |
leLkqvqvvfrhGartPikslPqeeeveWdkdlles.lp.dleidyrvtnln.Ge.pkPeskieekykkeilkGGafkGqLtkvGmqqvfdLGrkLrkrY

LKKHKLLPNDWSADQLYLETTGKSRTLQSGLALLYGFLPDFDWKK-----IYFRHQPSALFCSGSCYCPVRNQYLEKEQRRQyllrLKNSQLEKTYGEMA
. . |.|........ |.  |  .|||.|   |. |   .   .|     .| . . ..        ||  ...... ..      ..     .   ..|
vedikfLsqefnpqevyiRstnieRtlesarclvaGLygkiiiqkelpiilytdeedeevlyPnrqrcpllsrayrsvrksa....islpGisedtkqia

KIVDVPT-KQLRAANPIDSMLCHFCHNVSFPCTRNGCVDM-EHFKVIKTHQIEDErERREKKLYFGyslLGAHPILNQTIGRMQRATEGRKE-ELFALYS
. .|.   |.|      | .  .  ||.. |   .  .|. |.  | .   .  . . | .|       | . ..|.. . ....|.|.  . . . |||
dvldiseekkldfvslrDniaArlaHnlkvppilkdvidliekhAveelvvlleg.gdrpekeilk...lsvGkvlkeilenlekakekeiparklrLys

AHDVTLSPVLSALGLSEARFPRFAARLIFELWQDreKPSEHSVRILYNGVDVTF
|||.||...| |||  . ..| ||| .|.||..|  |  |. ||.||..  . .
aHDttlmtLLlalgvFDdkWPpfaadvileLyed..kageyfvrvlYqekelrl
0049226 Phosphoglycerate mutase-like 87-475 1e-67 221.8 In-house 2-340 (342) alignment 
Range on Protein: 87-475
Range on HMM: 2-340/342.0
KLVSVHVFIRHGDRYPLYVIPKTKRPEIDctlvanrkpyhpkleafishmskgsgasfesplnslplypnhPLCEMGELTQTGVVQHLQNGQLLRDIYlk
||. |.|.||||||.||. .|.. ..|.                                           . | .||||..|..|. . |. ||..|  
kLkqvqvliRHGdRtPlakgpldflnewf..........................................wgcglgeLTplGreqayelGrrlrkrY..

kHKLLPNDWSADQLYLETTGKSRTLQSGLALLYGFLPDFD------------WKKIYFRHQPSALFCSGSCYCPVRNQYLEKEQRRQYLLRLKnSQLEKT
 ..|||.... |..|. .....|||||. |.|.|..|.              .. |.. .  ..|.. ....||  ...|.. .  ... ... ......
.lgllpstynpdevyvrssdvdRtlqSaqaflaGlfppeltpilvplldwqpipiitepesndtllllpydscpnfdkllkellkseevqlfl.eeildl

YGEMAKIVDVPT-KQLRAAN-PIDSMLCHFCHNVSFPCTRNGCVDMEHFKVIKTHQIEDERERREKklyfGYSLLGAHPILNQTIGRMQRATEGRKEELF
. ...|.....      .|.   | .|.. .|....|.  . .   |. ..   .. .     .       ...| ..|.||. . |...|.|| ..  .
lkklskllglnlstlsdvadtlydlllyelahglplppwcslftleelkalyaldllyyygigyge....eiarlaggpllneilarleeaiegpsdlkl

ALYSAHDVTLSPVLSALGLSEARFPRFAARLIFELWQDRekpSEHSVRILYNGVD----VTFHTSFCqdhhkrspKPMCPLENLVRFVKRDMFvalggsg
 ||.|||.|. ..|||||| . ..| .|..|.|||...    .|..||.||||      ||..  .|        . .|||......||. ..       
ylyfahdttiaallsalglfddqlPpyasnlvfElyecd...geyyVrvlynggvlslpvtlplpgc........dglcpldefkelvkkflp.......

TNYYDAC
......|
gdfeelC
0053031 Phosphoglycerate mutase-like 87-459 7.9e-67 218.9 In-house 2-331 (342) alignment 
Range on Protein: 87-459
Range on HMM: 2-331/342.0
KLVSVHVFIRHGDRYPLYVIPKTKRPEIDCtlvanrkpyhpkleafishmskgsgasfesplnslplypnhpLCEMGELTQTGVVQHLQNGQLLRDIYlk
.|. |.|..|||.|.||. .|.. ..|  .                                           | .||||..|. |... |. ||..|  
eLkqvivlvRHGaRtPlskgpldplnewfy..........................................pcgageLTplGreqayelGrrlrkrY..

kHKLLPNDWSADQLYLETTGKSRTLQSGLALLYGFLPDFD------------WKKIYFRHQPSALFCSGSCYCPVRNQYLEKEQRRQYLLRLKNsQLEKT
 ..|||. .. |..|. .... |||||. |.|.|..|. .            .. ...   ..||.. ....||  ...|.. .  ... .|.. .... 
.lgllpstynpdevyvrssdvdRtlqSAqaflaGlfppegtpilnpllgwqpipihtepessdalllpnydpcpafdkllkealaseevkelle.rylel

YGEMAKIVDVPTKQLR--AANPIDSMLCHFCHNVSFPctrnGCVDMEHFKVIKTHQIEDERERREKKLYFGYSLLGAHPILNQTIGRMQRATEGRKEELF
. ...|........|.  . .  |..|.. .|. ..|     ..........|.   .| .          .. | ..|.||. . |......| ..  .
lqklskglgltlsdlldlvsdlydlllyelahglplp....pwctlftleelkalyaldllyyyglgpgnelaklaggpllneilarleekisgpldlkl

ALYSAHDVTLSPVLSALGLSEARFPRFAARLIFELWQDRekpSEHSVRILYNGV------DVTFHtsFCqdhhkrsPKpMCPLENLVRFVKRD
 ||.||| |. ..|||||| . ..| .|..|.|||..|    .|..||.||||       .....  .|       .  .|||......||  
ylyfahdttiaallsaLglfddqlPpyasnlvfElyedp...geyyVrvlynggtlseplvlplp..gc.......dg.lcplsefkelvkkl
His_Phos_2 Histidine phosphatase superfamily (branch 2) 87-424 3.1e-46 150.8 Pfam-A 1-347 (347) alignment 
Range on Protein: 87-424
Range on HMM: 1-347/347.0
KLVSVHVFIRHGDRYPLYVIPKTKRPEIDCTLVAnrkpyhpkleafiSHMSKGSGASFESPLNSlplYPNHPLCEMGELTQTGVVQHLQNGQLLRDIYLk
.| .|.| ||||||.|.   .|. . |... |.               ...  .. .|    ..     ..  ...|.||..|  |. . |. ||  |  
eLkgvvvviRHGdRtPkqkfkksvtsekfisllk.............lknvlekkghfpgtkrk...eklqlilkwgglThsGrkqaeelGeqlrqrYp.

khKLLPNDWSADQLYLETTGKSRTLQSGLALLYGFL-PDF-----------DWKKIYFRHQPS------ALFCSGSCYCPVRNQ-YLEKEQRRQYLLRLK
  .||.... .....  .. . |.|.|. |...|.| |.            |.... .....       .| . |.. ||  .. ... |.| . |..  
..gllrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnkl

NSQLEKTYG-EMAKIVDVPTKQLRAANPIDSMLCHFCHNvSFPCTRNGCV-DMEHFKVIKTHQIEDERERREK-KLYFGYSLLGAHPILNQTIGRMQRAT
...... .  .. ...  ... |  ... .   ..|...  |  ..  .. |   .....  |.|| .|     .      |  ....||. ........
kkvmdenlakrlsalctgednllfkerweklfreffeee.kfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdl

EGRK---EELFALYSAHDVTLSPVLSALGLSE------ARFPRFAARLIFELWQDREKPseHSVRILYN
|...   .. . ||..|| .. ..|.||||.|      .. . .|....|||..|.||   ..||.|..
eetqpsrhaklrlyfthDshiytllnaLgleekiareaspelpyasqivfelyedsekk..fyvrllfs
His_Phos_2 Histidine phosphatase superfamily (branch 2) 87-424 3.1e-46 150.8 In-house 1-347 (347) alignment 
Range on Protein: 87-424
Range on HMM: 1-347/347.0
KLVSVHVFIRHGDRYPLYVIPKTKRPEIDCTLVAnrkpyhpkleafiSHMSKGSGASFESPLNSlplYPNHPLCEMGELTQTGVVQHLQNGQLLRDIYLk
.| .|.| ||||||.|.   .|. . |... |.               ...  .. .|    ..     ..  ...|.||..|  |. . |. ||  |  
eLkgvvvviRHGdRtPkqkfkksvtsekfisllk.............lknvlekkghfpgtkrk...eklqlilkwgglThsGrkqaeelGeqlrqrYp.

khKLLPNDWSADQLYLETTGKSRTLQSGLALLYGFL-PDF-----------DWKKIYFRHQPS------ALFCSGSCYCPVRNQ-YLEKEQRRQYLLRLK
  .||.... .....  .. . |.|.|. |...|.| |.            |.... .....       .| . |.. ||  .. ... |.| . |..  
..gllrdhltyedvkirssserRvlaSAqafaaGllgpegelllsirkdllddsnaakdtmdevkkklkellregaescpafawppikvekrvvelvnkl

NSQLEKTYG-EMAKIVDVPTKQLRAANPIDSMLCHFCHNvSFPCTRNGCV-DMEHFKVIKTHQIEDERERREK-KLYFGYSLLGAHPILNQTIGRMQRAT
...... .  .. ...  ... |  ... .   ..|...  |  ..  .. |   .....  |.|| .|     .      |  ....||. ........
kkvmdenlakrlsalctgednllfkerweklfreffeee.kfdiskipelydtmkydalhnrqledleelyklygigdeeklkigllllnpllkkilsdl

EGRK---EELFALYSAHDVTLSPVLSALGLSE------ARFPRFAARLIFELWQDREKPseHSVRILYN
|...   .. . ||..|| .. ..|.||||.|      .. . .|....|||..|.||   ..||.|..
eetqpsrhaklrlyfthDshiytllnaLgleekiareaspelpyasqivfelyedsekk..fyvrllfs
subfamily_HP2-Group1_pd Subfamily HP2-Group1 295-438 9.9e-16 49.1 In-house 252-393 (422) alignment 
Range on Protein: 295-438
Range on HMM: 252-393/422.0
IDSMLCHFCHNVSFPCTRNGCV--DMEHFKVIKTHQIeDERERREKklyfgYSLLGAHPILNQTIGRMQRATEGRKEELFALYSAHDVTLSPVLSALGLS
.| .  |.|||...|      .   .    . ....       .||     |.  |   .| .    .... .| . . |.||| || || ..||||...
vdclithqchnaaipdkltedlakrgldellyrsyss.lkypsvek.....yarvGiGfllkdiwkevnesltGedlrkfllysGhdttliqllsalnvd

EARFPRFAARLIFELWQDREKPS----EHSVRILYNGVDVTFhtSFCQDH
| ..| .|. |..||..    |.    ...||.||||   ..   ||. .
efkwppyasllllellevstapaastpqyavrvlynGklkkl..pfcdan