Gene CDC14 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily CDC14
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP001_AA protein Get Run
MbreP001_AA_223-398 phosphatase_domain Get Run
MbreP001_AA_417-572 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
0048567 (Phosphotyrosine protein) phosphatases II 222-401 4.7e-40 131.3 In-house 3-156 (157) alignment
Range on Protein: 222-401
Range on HMM: 3-156/157.0
QIDNACVIVPDRLYFATVRQLPPSTPEAFFFTVDSEFKYEafvsrpathaprnsapspqpfgltmcGFCADFGPFNLSTSVRFCRKLWQFLEQPQHKDQR
.. ....|.|||||||....|| |...|..|..| .. ||                           |..||||.||.. .||..||..||.........
engdlieiipdrlyfallprlpkslynalyFsiddglvye..........................dfffdfGPlnlailyrFilklnkflkilelagka

IYFCTGTDMQVRSNAAALIGLFAVWCLNMTDEQAIACLDTAKPPFAPFRDASYAPVLYKLHVRYVISGAYQALLNGFIDV
|.... .... |...| |||......|..| |.|||.|  . |.. |||||||.. ||.|..  |..| ..|| .||.|.
iavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynltlldvlyGllkAlelgfldl

subfamily_CDC14_pd Subfamily CDC14 224-574 2.2e-158 521.3 In-house 1-326 (328) alignment
Range on Protein: 224-574
Range on HMM: 1-326/328.0
DNACVIVPDRLYFATVRQLPPSTPEAFFFTVDSEFKYEafvsrpathaprnsapspqpfgltmcGFCADFGPFNLSTSVRFCRKLWQFLEQPQHKDQRIY
|||.....|||||||.|. | ||.|...|.||.|.|||                           |.|||||.||....|.|.||...|.........|.
dnalelledrlyfatlrkkPkstselhyfsvddelkye..........................nfyadfGPlnlavlyrycvklnkkLkseekaskkiv

FCTGTDMQVRSNAAALIGLFAVWCLNMTDEQAIACLDTAK-PPFAPFRDASYAPVLYKLHVRYVISGAYQALLNGFIDVHTFDLDTYDHFERVENGDFTT
..|..|.. |.|||.|||..||..|..|.|.|...|..|. |||.|||||||... |||....|..|...|| .||.|...|||..|...||||||||..
lytsadskkranaalligayaviylkktaeeayraleaaetppfvpfrdasygsasykltlldvlkgvekalqkgfldledfdleeYekyervenGDfnw

IIPNKFIALAGPHNTRHVDDGYTHLAPENLFEPFRRLGVTDIVRLNKKMYDRTKFTQAGFAHHDLFFIDGTCPPPAILESFLEITEKCTGTAVVHCKAGL
|.|.||.|||||||.....|||.. |||.|.| ||. .||..||||||.||..|||.|||.|.|||||||..|. ||...||||.||..|...|||||||
ivPdkflalagPhnkskledgyplhaPeklleyfrknnvttvvrLnkklYdakkftdaGfdhkDlffiDGstPsdaivkkfleiaekaeGaiavhCkaGL

GRTGSLIGCYMMKHYRFNAPETIAWLRIARPGSVIGPQQTYLVNHQADMWLA
||||.||.||.||||||.|.|.||||||.||||||||||..|...||..|| 
GrtGtLiacylmkhyrftaaeaiawlricrPGsvigpqqkfleekqaalwle

DSPn Dual specificity protein phosphatase, N-terminal half 228-264 7.4e-10 29.7 Pfam-A 2-38 (141) alignment
Range on Protein: 228-264
Range on HMM: 2-38/141.0
VIVPDRLYFATVRQLPPSTPEAFFFTVDSEFKYEAFV
 ...|||||..... | .|.. ..|..|.|..|| |.
eliedrLyfvslkkkpkktenthyfsiDeelvYepfy

DSPn Dual specificity protein phosphatase, N-terminal half 288-393 1e-30 97.3 Pfam-A 36-141 (141) alignment
Range on Protein: 288-393
Range on HMM: 36-141/141.0
GFCADFGPFNLSTSVRFCRKLWQFLEQPQHKDQRIYFCTGTDMQVRSNAAALIGLFAVWCLNMTDEQAIACLDTAKPPFAPFRDASYAPVLYKLHVRYVI
.|.||||| ||.  .|||.|| . |.....|...|...|..|.. |.||| ||| .|| .|... |.|.. | ...|.. ||||||| .  |.|..  ..
pfyadFGPlnlaqiyrfcvklnkkLkeaelkkkkivlytsldekkranaalLigaYavivlklspeealkplesvepsllpFrDAsygestyeltildcl

SGAYQA
.| ..|
kglekA

0050432 (Phosphotyrosine protein) phosphatases II 361-567 1e-32 109.1 In-house 6-293 (308) alignment
Range on Protein: 361-567
Range on HMM: 6-293/308.0
TAKPPFAPFRDASYAPVLYKLHVRYVISGAYQALLNGFID------VHTFDLDTYDHFERVENGDFTT-------------------------------I
 | ... .|||.|. .. .||.|  ..   ..|| .|...       ....| .|......||.|.                                 .
dallelllfrdtsilvsslklsvldllkllekaldlglleeefeellsvkplleysvallpenkdkNrykdilpydhsRVkldegsdYInAsyvdgyssk

IPNKFIALAGPHntrhvddgytHLAPENLFEPFRRLGVTDIVRLNKKMYDR-TKFTQ-------AGFAHHDLFFI-------------------------
.|.||||  ||.          .   |. .  .   .|. ||.|.| ...   |. |        |. ... |..                         
lprkfIatqgPl..........pntvedFwrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdge

-------------DGTCPP-PAILESFLEITEKC--TGTAVVHCKAGLGRTGSLIGCYMM-----KHYRFNAPETIAWLRIARPGSVIGPQQTYLVNH
             |. .|| |.|| .|||. .|.   |. ||||.||.|||| .| ....     |.......|....||  |||.|..|.| ... .
srtvthfhytnWpdhgvPpspeilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpeqylflyr

0045450 (Phosphotyrosine protein) phosphatases II 364-565 1.7e-30 102.3 In-house 3-296 (307) alignment
Range on Protein: 364-565
Range on HMM: 3-296/307.0
PPFAPFRDASYAPVLYKLHVRYVISGAYQALLnGFIDVHTFDLDTYDHFERVENGDFTTI----------------------------------------
.|. .|.|| .   |..| ..  ..| ...    ...|..|.|..|......||.|.  .                                        
lplslfidalkllllvllllldfltgllkefe.kllsvtvfllgeysiallpenkdknrykdilpydhtRVklssldgsledsdYiNAsyvrvpllllld

---IPNKFIALAGPHNTrhvddgythlAPENLFEPFRRLGVTDIVRLNKKMYDRTK------------------------------------------FT
   ...||||  ||..            .|. .. ....||| ||.|.. ...  .                                          .|
gydlkrkfIatqgPlpe..........tvedFwrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgt

QAGFAHHDLFF---IDGTCPP-PAILESFLEITEK------CTGTAVVHCKAGLGRTGSLIGCYMMKHYR--------FNAPETIAWLRIARPGSVIGPQ
. .. .. ...    |...|| ...| .|.|. .|      . |  .|||.||.||||..|..|.|....        ....|....||  |||.|  |.
gesrtvthfhytgwpdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpe

QTYLV
| . .
qyrfl

0039614 (Phosphotyrosine protein) phosphatases II 368-566 4e-30 100.7 In-house 3-282 (297) alignment
Range on Protein: 368-566
Range on HMM: 3-282/297.0
PFRDASYAPVLYKLHVRYVISGAYQALLNGFIDVHTFDL----DTYDHFERVENGDFTTII------------------------------------PNK
|.|||.. .....|.|  .. . ..|. ..... . ..|    . | .....||.|.  ..                                    ..|
plrdallesipiplsvldlllllekansktllllefeellslkpdysiallpenkdknrykdilpydhsrvklkpedgvdldsdYinAsyvdgydlltrk

FIALAGPHNTrhvddgythlAPENLFEPFRRLGVTDIVRLNKKMYDRTKF----------------------TQAGFA-----------------HHDLF
|||  ||..            .|. .. ....||| ||.|.| ...  |.                      . .|.                  .. . 
fIatqgPlpe..........tvedFwrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytg

FIDGTCPP-PAILESFLEITEK------CTGTAVVHCKAGLGRTGSLIGCYMM-----KHYRFNAPETIAWLRIARPGSVIGPQQTYLVN
. |...|| ...| .|||. ..        |  .|||.||.||||..|..|.|     |.......|....|| .|||.|  |.| . . 
wpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrfly

0049772 (Phosphotyrosine protein) phosphatases II 379-561 2.3e-32 108.4 In-house 79-268 (314) alignment
Range on Protein: 379-561
Range on HMM: 79-268/314.0
YKLHVRYVIsGAYQALLNGFIDVHTFDLDTYDHFERVENGDFTTIIPNK---------------------FIALAGPHntrhvddgythlapenlfepfR
|   ..  |  .   | ....| .....  |.....|..||. .... .                     .. | |..                      
yvdgflkfI.atqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng.....................n

RLGVTDIVRLNKKMYDRTKFTQAGFAHHDLFFIDGTCPPPAILESFLEITEK--CTGTAVVHCKAGLGRTGS-LIGCYMMKHYRFNAPETIAWLRIARP-
 . . |.  |.. .||. .|...|. .... . ||..|.......|||. |.    |  .|||||| ||||. .. .|.||...... |.....| .|| 
eptaadlellkeelydpelferlgikylripvpDgsaplledfdeflefieeadkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRpi

----GSVIGPQQ
    |..  ..|
npnpgfieqleq

0040438 (Phosphotyrosine protein) phosphatases II 381-567 1.8e-33 111.6 In-house 7-270 (317) alignment
Range on Protein: 381-567
Range on HMM: 7-270/317.0
LHVRYVISGAYQALLNGFIDVHTFDLDTYDHFERVENGDFTTII----------------------------------PNKFIALAGPHNTrhvddgyth
|.. ... .  .|||..|.|. ...||||...|..||.|.  .                                   ..||||  ||..          
lalldllksdftalleefedllslkldtysvaelpenkdknrypdilpydhsRVkLsplggdldsdYInAsyvdgpnlkrkfIatqgPlpn.........

lAPENLFEPFRRLGVTDIVRLNKKMYD------------------------RTKFTQAGFAHHDLFF-------------------IDGTCPP-PAILES
   |. .. . ..||| ||.|.. ...                        .  .. ||. .. | .                    |...|| | .| .
.tvedFwrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllld

FLEITEKC----TGTAVVHCKAGLGRTGSLIGCYMM-----KHYRFNAPETIAWLRIARPGSVIGPQQTYLVNH
|||. ...     |  .|||.||.||||..|..|.|     |.......|....|| .|||.|  |.| . .  
fleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflyd

0043336 (Phosphotyrosine protein) phosphatases II 381-565 1.5e-30 102.0 In-house 9-269 (278) alignment
Range on Protein: 381-565
Range on HMM: 9-269/278.0
LHVRYVISGAYQALLNGFIDVHTFDLDTYDHFERVENGDFTTII----------------------------------PNKFIALAGPHNTrhvddgyth
 .....  . ...||..| ....|.||||......||.|.  .                                   |.||||  ||..          
kallelllnlktllllefeellsfkldtysiallpenkdknrykdilpydhsrvklsllggdldsdYinAsyvdgynvprkfiatqgPlpe.........

lAPENLFEPFRRLGVTDIVRLNKKM--------------------------------------------YDRTKFTQAGFAHHDLFfiDGTCP-PPAILE
  .|. .. .. |||| ||.|.. .                                            .|  ..|  .. ...    |...| ....| 
.tvedFwrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp..dhgvpeslslll

SFLEITEK----CTGTAVVHCKAGLGRTGSLIGCYMM-----KHYRFNAPETIAWLRIARPGSVIGPQQTYLV
.||..  .    . |  .|||.||.|||| .|..|..     |.......|....||  |||.|  |.| . .
dflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrfl

0047943 (Phosphotyrosine protein) phosphatases II 391-566 4.6e-24 80.8 In-house 18-265 (273) alignment
Range on Protein: 391-566
Range on HMM: 18-265/273.0
YQALLNGFIdvhtfdLDTYDHFERVENGDFTTI------------------------------IPNKFIALAGPHNTRhvddgythlaPENLFEPFRRLG
...||. ..      | || .....||.|.  .                              ...||||  || .             |. .  .   .
felllslkp......lltysvallpenkdknrykdilpydhsrvklgdggsdyinAsyvdgynlkrkfiatqgPlpnt..........vedfwrmvweqn

VTDIVRLNKKMYD----------------------------------------------RTKFTQAGFAHHDLFFIDGTCP-PPAILESFLEITEK----
|. ||.|.. ...                                               |. .     .| . . |  .|  ...| .|.|. .|    
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--CTGTAVVHCKAGLGRTGSLIGCYMM-----KHYRFNAPETIAWLRIARPGSVIGPQQTYLVN
    |. ||||.||.||||..| ....     |.......|....||  |||.|. |.| ... 
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfly

0045098 (Phosphotyrosine protein) phosphatases II 393-571 4.6e-30 100.4 In-house 9-271 (278) alignment
Range on Protein: 393-571
Range on HMM: 9-271/278.0
ALLNGFIDVHTFDLDTYDHFERVENGDFT----------------------T-IiPNKFIALAGPHNtrhvddgythLAPENLFEPFRRLGVTDIVRLNK
.|| ..  ..... ... .. ...|.|.                       .   |.|||| .||..             .. .. .. ||.| ||.|..
lllefefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgy.pkkfIatqgPlp..........stvadfwrmlwelgitvivmlte

KMYDR----------------------------------------------TKFTQAGFAHHDL-FFIDGTCPPPAILESFLEITE--------------
 ...                                               . ....|. |... .. |...|.  || ||||..|              
lvelgrekcaqywpeggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslll

------KCTGTAVVHCKAGLGRTGSLIGCYMMKHY---RFNAPETIAWLRIARPG-SV-IGPQQTYLVNHQADM
         |. .|||.||.|||| |...|.|...   .....|....||  ||| .| .  |. .|   ....
sslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel

0044763 (Phosphotyrosine protein) phosphatases II 402-571 9.3e-31 102.2 In-house 5-170 (178) alignment
Range on Protein: 402-571
Range on HMM: 5-170/178.0
HTFDLDTYDHFERVENGDFTTIIPNKFIALAGPhntrhvddgythlapENLFEPFRRLGVTDIVRLNKKMY------DRTKFTQAGFAHHDLFFIDGTCP
. ..|... ..||... ... |.|. ... ..|               .. .| ...||.| ||.|.. ..      |.  ...||. .. . . |...|
trvllsnleglersdyinaseilpglylgslpp...............addlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvp

P-PAILESFLEITE----KCTGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARPGSVIGPQQTYLVNHQADM
. ..... |.|. |    .. |. .|||.||.||.|.|. .|.||.......| |...| .||..    |. .|   .  .
dllehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpivpnpgqlrqLyefelrl

0041856 (Phosphotyrosine protein) phosphatases II 405-568 3.6e-36 119.8 In-house 3-166 (182) alignment
Range on Protein: 405-568
Range on HMM: 3-166/182.0
DLDTYDHFERVENGDFTTIIPNKFIALAGPHNTRHVDDGYTHLAPENLFEPFRRLGVTDIVRLNKKMYDRTKFTQAGFAHHDLFFIDGTCPPPAILESFL
|.. | .. ..... . . | ..... . |... ..  |..   ... .. ...||.| ||.|.  .|. ......|. ...|.. |...|.. .| .|.
dknrysdilpydhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpdldelldfi

EITEKCTGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARPGSVIGPQQTYLVNHQ
|. ..  |. .|||.||.||||.|...|.||.......|.....| .|||.|| |.| ...  .
eevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqla

0051429 (Phosphotyrosine protein) phosphatases II 405-568 1.2e-17 59.9 In-house 2-220 (272) alignment
Range on Protein: 405-568
Range on HMM: 2-220/272.0
DLDTYDHFERVENGdFTTIIPNKFIALAGPHNTRHVDdgythlapenlFEPFRRLGVTDIVRLNKKM---YDRTKFTQAGFAHHDLFFIDGTCPPP----
.|..| ..  |    . ...|..... .||..  . |           |. ...||.. || | . .   .. . .  .|. .. | ..| . |..    
plsgyiNardvggy.grvvkpgrlyrsggplpltaad...........fwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilyga

------------------------------------------------AILESFLEITEKcTGTAVVHCKAGLGRTGSLIGCYMMKhYRFN---------
                                                  | ..||.  .  |  .|||.|| .||| .. ....  ....         
lrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYl

-----APETIAWLRIARPGSVIGPQQTYLVNHQ
     . |....|| .|||.|  ..| . . . 
ltnlyleeaveelraqrpgavqteeqylflyea

0038934 (Phosphotyrosine protein) phosphatases II 409-562 1.3e-35 118.2 In-house 6-166 (194) alignment
Range on Protein: 409-562
Range on HMM: 6-166/194.0
YDHFERVENgdfttIIPNKFIALAGPHNTR--HVDDGYTHLAPENLFEPFRRL--GVTDIVRLN--KKMYDRTKFTQAGFAHHDLFFID-GTCPPPAILE
. ..|||..     ||...|||...|.. .  .. ... ...||.|.. .. |  ... ...|.  ...||...|..||. ...|.|.| ||.|. .|| 
wlkyervgd.....iitgrfiafkvPlsgsldkyieelyrfspedlvrylkllnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleill

SFLEIT-----EKCTGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARPGSVIGPQQT
.||..      |.  |. .||||||||||| |...|........| | ||..|..|||... ... 
rfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyl

PTEN_1 409-570 6.3e-25 83.1 In-house 14-190 (196) alignment
Range on Protein: 409-570
Range on HMM: 14-190/196.0
YDHFERVENGDFTTIIPNKFIALAGP-HNtRHVDDGYTHLAPEN--LFEPFRRLGVTDIVRLNK------KMYDRTKFTQAGFAHHDLFFIDGTCPPPAI
... | .... .|. |  .. | . | .  .. .. |   ....  ... .   |.| .|.|.       . || ..| . |. .... . | . |. . 
alptelldltyitsriiamgkapsrpllq.eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslse

LESFLEITEKC------TGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIAR-PGSVIGPQQTYLVNHQAD
|  ...  . .       ....|||||||||.| .. .|.|......| |.....|..| ||..  |.|  |.. .|.
lfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfae

0042113 (Phosphotyrosine protein) phosphatases II 410-565 7.3e-29 96.3 In-house 2-235 (245) alignment
Range on Protein: 410-565
Range on HMM: 2-235/245.0
DHFERVENGDFTTI----------------------------------IPNKFIALAGPHNTrhvddgythlAPENLFEPFRRLGVTDIVRLNKKMYD--
......||.|.  .                                  |..|||| .||..            .|. .. ...||.| ||.|.. ...  
svallpenkdknrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpe..........tvedfwrmlwelgittivmLteeeelgr

-----------------------------------------RTKFTQAGFAHHDLFFIDGTCPP-PAILESFLEITEK-----CTGTAVVHCKAGLGRTG
                                         ...... .. .| | . |...|. ...|..|||. .|       |. .|||.||.||||
vkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtG

SLIGCYMM-----KHYRFNAPETIAWLRIARPGSVIGPQQTYLV
 .|..|.|     |.......|....||  |||.|  |.| . .
tfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrfl

0040439 (Phosphotyrosine protein) phosphatases II 411-565 1.4e-27 92.3 In-house 5-238 (249) alignment
Range on Protein: 411-565
Range on HMM: 5-238/249.0
HFERVENGDFTTI----------------------------------IPNKFIALAGPHNTrhvddgythlAPENLFEPFRRLGVTDIVRLNKKM-----
.....||.|   .                                  |...|||  || .           . |. .. ...||.| ||.|.. .     
vallpenkdknrypdilpydhsrvklsilpglflsdyinAsyidgyyikrrfiatqgPlpe..........tvedfwrmlwelgitvivmLtslvelgre

----------------------------------------YDRTKFTQAGFAHHDLFfIDGTCPPPAILESFLEITEK------CTGTAVVHCKAGLGRT
                                        || ...|  .. ..|.   .|..| ...| .|.|. .|      . |  .|||.||.|||
kcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRt

GSLIGCYMM-----KHYRFNAPETIAWLRIARPGSVIGPQQTYLV
| .|..|.|     |.......|....|| .|||.|  |.| . .
GtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfl

0043147 (Phosphotyrosine protein) phosphatases II 413-567 1.7e-32 107.9 In-house 8-155 (172) alignment
Range on Protein: 413-567
Range on HMM: 8-155/172.0
ERVENGDFTTiIPNKFIALAGPhntrhvddgyTHLAPENLFEPFRRLGVTDIVRLNKKMYDRTKFTQAGFAHHDLFFIDGTCPPPAILESFLEITEK---
..... |..  ||..|||  ||          .    .  .. ...||.| ||.|.. .||...... |. .. | . |...|....|..|||. ..   
inasyldlyy.ipdrfiatqgp..........lrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidella

--CTGTAVVHCKAGLGRTGSLIGCYMMKhYRFNAPETIAWLRIARPGSVIGPQQTYLVNH
    |. .|||.||.|||| |. .|.|. ..... |..|..| .|||.|  |.| ... .
lspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyy

0037934 (Phosphotyrosine protein) phosphatases II 414-566 6.4e-30 99.9 In-house 33-235 (243) alignment
Range on Protein: 414-566
Range on HMM: 33-235/243.0
RVENGDFTTIIPNkFIALAGPHNTRHVDdgythlAPENLFEPFRRLGVTDIVRLNKKM------------------------------------------
   |...... |. .||  ||..  . |      .... .. . .||.| || |.. .                                          
dyinanliyvtpr.liatqgPlpetved......dlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllen

YDRTKFTQAGFAHHDLFFIDGTCPP-PAILESFLEITE------------KCTGTAVVHCKAGLGRTGSLIGCYMMKHY-RFNAPETIAWLRIARPG-SV
.| ...|. .. .| | . |...|. |..| .||...             .  |. .|||.||.|||| || .|.|... .... |....||  ||| .|
ldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkav

IGPQQTYLVN
  |.| . . 
qtpsqyrfly

0048567 (Phosphotyrosine protein) phosphatases II 415-572 8.4e-35 114.3 In-house 2-138 (157) alignment
Range on Protein: 415-572
Range on HMM: 2-138/157.0
VENGDFTTIIPNKFIALAGPHNTRhvddgythlapenlfepfrrlgvtdivrlnkKMYDRTKF-TQAGFAHHDLFFIDGtcPPP--------AILESFLE
.||||...|||..... ..|. ..                               ..|..  | ...|. ..|.|| .|  |..         .|..||.
kengdlieiipdrlyfallprlpk...............................slynalyFsiddglvyedfffdfG..PlnlailyrFilklnkflk

ITEKCTGTAVVHCKAGL---GRTGSLIGCYMMKHYRFNAPETIAWLRIARPGSVIGPQQTYLVNHQADMW
|.|.. .. .|||||||   |||. |||||...|..|.. |.||.|||.|||||......||. ..  ..
ilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllslynltl

0051082 (Phosphotyrosine protein) phosphatases II 419-567 2e-26 87.8 In-house 7-147 (151) alignment
Range on Protein: 419-567
Range on HMM: 7-147/151.0
DFTTIIPNkFIALAGPHNtrhvddgythlapeNLFEPFRRLGVTDIVRLNKKM---YDRTKFTQAGFAHHDLFFIDGTCPPP----AILESFLEITEKC-
.|. . .. ... .||..                .| ...||.. || |....   |.   ....|. .... ..| . |.     ... .|||. ... 
nfsyvtgg.lyrsggpla..............dflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkk

TGTAVVHCKAGLGRTGSLIGCYMMKhYRFNAPETIAWLRIARPGSVIGPQQTYLVNH
 |  .|||.||.|||| |...|.|. ..... |.....|. |||.|. .|| ... .
ngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf

0036282 (Phosphotyrosine protein) phosphatases II 422-565 1.5e-28 95.1 In-house 13-162 (174) alignment
Range on Protein: 422-565
Range on HMM: 13-162/174.0
TIIPNKFIALAGPHNtrhvddgythlapenLFEPFRRLGVTDIVRLNKKMYDR------------TKFTQAGFAHHDLFFIDGTCPPPAILESFLEITEK
..|....|| .||..                .| ...||.|..|.|.. ...             . ... |. ...| . |...|. .||..|... |.
syitprliagqgpla...............fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfvee

C-----TGTAVVHCKAGLGRTGSLIGCYMMKHYRF-NAPETIAWLRIAR---PGSVIGPQQTYLV
.      |. .|||.||.|||| |...|.|... . .. . ....| .|   ||.|. |.| . .
alsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrfl

0046845 (Phosphotyrosine protein) phosphatases II 423-567 5.4e-21 70.7 In-house 74-268 (284) alignment
Range on Protein: 423-567
Range on HMM: 74-268/284.0
IIPNKFIALAGPHNTrHVDDGYTHLAPEnlfepfrrlGVTDIVRLNKKMYDR---------------------------------------------TKF
.|..||||  || ..  |.| .  .  .         .|. || |.. . .                                              |..
yikkkfIatqgPlpn.tvedFwrmvweq.........nvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytge

TQAGFAHHDLFFIDGTCPP-PAILESFLEITEKC------TGTAVVHCKAGLGRTGSLIGCYMMKHY--------RFNAPETIAWLRIARPGSVIGPQQT
.     .| . . |  .|| |..| .||.. ...       |. ||||.||.|||| .| .......        .....|....||  |||.|  ..| 
srtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqy

YLVNH
..| .
rfvye

subfamily_RNGTT_pd Subfamily RNGTT 423-556 1.6e-09 31.7 In-house 13-158 (189) alignment
Range on Protein: 423-556
Range on HMM: 13-158/189.0
IIPNKFIALAGPHNTRHVDDG--YTHLAPENLFEPFR----RLGVTDIVRLNKKMYDRTKFTQAGFAHHDLFFI-DGTCPPPAILESFLEITEK-----C
.| .||...  |  .|. ||    ..  |. |.. ..    .||.   .  ....||. .... |  .. |     | .| .   ..| .. |.      
liaekflpfktplskrydddlaeenrfepsmllsylktlkvklglvidltntsryYdkeelekegikyvklqcagkgeaPeaeqvkefiklveeffkknp

TGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARPGSV
. .  |||. |  ||| || .|....  ... . .|  . |||  .
eevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGi

0051299 (Phosphotyrosine protein) phosphatases II 424-566 1.9e-20 68.9 In-house 90-279 (288) alignment
Range on Protein: 424-566
Range on HMM: 90-279/288.0
IPNKFIALAGPHNTrHVDDGYTHLAPEnlfepfrrlGVTDIVRLNKKM-----------------------------------------------YDRTK
...||||  || ..  |.| .  .  .         .|. ||.|.| .                                               .| ..
lkrkfIatqgPlpn.tvedFWrmvweq.........nvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdg

FTQAGFAHHDLFFIDGTCPP-PAILESFLEITEKC----TGTAVVHCKAGLGRTGSLIGCYMM-----KHYRFNAPETIAWLRIARPGSVIGPQQTYLVN
...    .| . . |  .|. |  | .||..  |.     |. ||||.||.|||| .| ....     |.......|....||  |||.|. |.| ..| 
esrtvthfhytnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpeqyrfvy





0049260 (Phosphotyrosine protein) phosphatases II 449-566 6.1e-28 92.8 In-house 22-143 (152) alignment
Range on Protein: 449-566
Range on HMM: 22-143/152.0
PENLFEPFRRLGVTDIVRLNKKMYDRTKFTQAGFAHHDLFFIDGTCPPPAILESFLEI-----TEKCTGTAVVHCKAGLGRTGSLIGCYMMKhYRFNAPE
 .. .. ...||.| ||.|.. ...   ..  .. .. |.. |...|. ..|  || .      ..  |. .|||.||.|||| |. .|.|. ..... |
ladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvslee

TIAWLRIARPGSVIGPQQTYLVN
..|..| .|||.|. |.| ... 
avalvrekRpgavpnpgqlrfly

0046846 (Phosphotyrosine protein) phosphatases II 449-571 6.3e-27 89.8 In-house 36-171 (176) alignment
Range on Protein: 449-571
Range on HMM: 36-171/176.0
PENLFEPFRRLGVTDIVRLNKK--------MYDRTKFTQAGFAHHDLFFIDGTCPPPAILESFLEITEKCT---GTAVVHCKAGLGRTGSLIGCYMMKH-
 .. .| ...||.| .|.|..         ...   ....|. .. | . |...|. ..|...||. ...    |. .|||.||.|||| |. .|.... 
ladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaayllele

YRFNAPETIAWLRIARP-GSVIGPQQTYLVNHQADM
. ... |..|..|  || |.|  |.| . . . . .
kglsveealalvreqRplgavqtpeQyrflyefell

0048179 (Phosphotyrosine protein) phosphatases II 453-565 3.4e-25 83.9 In-house 22-137 (144) alignment
Range on Protein: 453-565
Range on HMM: 22-137/144.0
FEPFRRLGVTDIVRLNKKmYDRTKFTQAGFAHHDLFFIDGTCPPP-AILESFLEITEKC---TGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWL
.| ...||.| ...|. . |. . ... |. .. | . |  .|.  ..|..|||. |..    |  .|||.||.||||.|. .|.||...... |..|..
lellkklgittvinltee.yepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklglsleealalv

RIARPGSVIGPQQTYLV
| .|||.|. |.| . .
rsrrpgavpnpgqlrfL

0048076 (Phosphotyrosine protein) phosphatases II 453-565 1.2e-24 82.0 In-house 22-135 (145) alignment
Range on Protein: 453-565
Range on HMM: 22-135/145.0
FEPFRRLGVTDIVRLnkkMYDRTKFTQAGFAHHDLFFIDGTCPPP-AILESFLEITEKC---TGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWL
.| ...||.| ...|   ..... ... |. .. | . | ..|.  ..|..|||. |..    |  .|||.||.||||.|...|.|........|.....
lellkdlgittvlnl...tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleealelv

RIARPGSVIGPQQTYLV
| .|||.|. |.| . .
rsqrpgavpnpgqlrfl

subfamily_PRL_pd Subfamily PRL 454-570 1.2e-14 48.7 In-house 28-148 (151) alignment
Range on Protein: 454-570
Range on HMM: 28-148/151.0
EPFRRLGVTDIVRLNKKMYDRTKFTQAGFAHHDLFFIDGTCPPPAILESFLEIT-----EKCTGTAVVHCKAGLGRTGSLIGCYMMKHyRFNAPETIAWL
| ... .|. .||  .  || .|. ..|   .|| | ||. || ...|..||.      |.   |  ||| |||||.  |.   .. .  ..  ... ..
eelkkeevktvvrvceptydteklekegievldlafddGavPpeevveeWlellkekfkeepkstvavhcvaGlGraPvlvalaliea.Gmkyedavefi

RIARPGSVIGPQQTYLVNHQAD
|  | |..   | ..| ...| 
rekrrgainskqlkflekykak

subfamily_DSP11_pd Subfamily DSP11 459-552 3.2e-07 24.4 In-house 57-157 (178) alignment
Range on Protein: 459-552
Range on HMM: 57-157/178.0
LGV-TDIVrLNKKMYDRTKFTQAGFAHHDLFFIDGTCPPPAILESFLEITEKCT-------GTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRI
||.  |.    .. |.....|. |  .. |.    . |   ....| |  .. .           |||  |. ||| ||  |....  ... . |  .  
lGLvidlt.ntdryykkkeltdegvkylklncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafee

AR
||
ar

0036941 (Phosphotyrosine protein) phosphatases II 460-569 7.3e-19 63.6 In-house 102-272 (297) alignment
Range on Protein: 460-569
Range on HMM: 102-272/297.0
GVTDIVRLNKKMYD---------------------------------RTKFTQAGFAHHD--------------LFFIDGTCPP-PAILESFLEITEK--
.|| || |.. . .                                  . .|.  .   |              .   |  .|. ||.| .|.|  .|  
nvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvl

----CTGTAVVHCKAGLGRTGSLIGCYMM--------KHYRFNAPETIAWLRIARPGSVIGPQQTYLVnHQA
      |  .|||.||.||.|..|....|        |..... .|.. .||  |||.|  ..| . . ..|
kllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrfl.yea

subfamily_DSP23_pd Subfamily DSP23 460-566 1.1e-13 46.1 In-house 31-139 (148) alignment
Range on Protein: 460-566
Range on HMM: 31-139/148.0
GVTDIVRLNKKMYDRTKFTqAGFAHHDLFfIDGTCPP-PAILESFLEITEKCT--GTAV-VHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARPGS
||  .| | ..   ... |  . . . |  ||  .|| .  .. |... |.    . || |||  | ||||... ||..|. .. | |.|| .|  ||||
gvrylvslteegrphveat.pnltlvrlr.iddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrpgs

VIGPQQTYLVN
|   .|  || 
vetveqeklvr

subfamily_PTEN_pd Subfamily PTEN 470-552 2.8e-09 32.2 In-house 71-156 (184) alignment
Range on Protein: 470-552
Range on HMM: 71-156/184.0
KMYDRTKFTQAgFAHhdLFFIDGTCPPPAILESFLEITE-----KCTGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAP-ETIAWLRIAR
. || .||..   |.  . | | . ||  .||...|  |     . .  .||||||| |||| || .|..|.  .. . |....   ||
rkydskkfdgr.vav..ypfdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR

subfamily_PTPDC1_pd Subfamily PTPDC1 472-566 1.2e-13 46.0 In-house 73-169 (182) alignment
Range on Protein: 472-566
Range on HMM: 73-169/182.0
YDRTKFTQAGFAHHDLFFID-GTCPPPAILESFLEITEKCT-GTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARPGSVIGPQQTYLVN
||  .....| ... . . | |...   ||.    ..  .. |   ||| ||||||| || ||.. . |..| ..|  .|  || |.   .|  ||.
YdlealmeqgiyvynfgwkDygvasleriLdivkvvafalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvk

subfamily_PTPMT1_pd Subfamily PTPMT1 476-566 6.2e-09 30.5 In-house 68-162 (171) alignment
Range on Protein: 476-566
Range on HMM: 68-162/171.0
KFTQAGFAHHDLFFIDGT-CPPPAILESFLEITEKCT--GTA-VVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARPGSVIGPQQTYLVN
.... |  .  |  .| |  |  . ||  .|. || .  |    |||||| ||...|..||.||.....  | .  |.  |.   .  .|  ...
ewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalq

subfamily_CDKN3_pd Subfamily CDKN3 476-552 5.2e-06 20.2 In-house 94-174 (202) alignment
Range on Protein: 476-552
Range on HMM: 94-174/202.0
KFTQAGFAHHDLFFIDGTCPPPAILESFLE---ITEKCTGTAVVHCKAGLGRTGSLIGCYMMK-HYRFNAPETIAWLRIAR
...|||.. |   . ||. | .|    .||   |. |    ..|||  ||||.  .| | ..  .  ..  ..|. ||  .
lyqqaglivhhypiadglvpdiasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlk

DSPc Dual specificity phosphatase, catalytic domain 502-559 9.4e-12 39.9 Pfam-A 64-119 (133) alignment
Range on Protein: 502-559
Range on HMM: 64-119/133.0
SFLEITEKCTGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARpgSVIGP
.|.|  |.  .. .|||.||. |...|| .|.|| ..... | .. ..  |  | | |
efiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr..skisp

DSPc Dual specificity phosphatase, catalytic domain 502-559 9.4e-12 39.9 In-house 64-119 (133) alignment
Range on Protein: 502-559
Range on HMM: 64-119/133.0
SFLEITEKCTGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARpgSVIGP
.|.|  |.  .. .|||.||. |...|| .|.|| ..... | .. ..  |  | | |
efiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerr..skisp

PTPc_motif_SM00404 502-560 1.1e-10 36.5 In-house 71-127 (140) alignment
Range on Protein: 502-560
Range on HMM: 71-127/140.0
SFLEITEKCTGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARpgSVIGPQ
.|.|  ||  |. .|||.||. |...|| .|.|. . ... | .  ..  |  . | |.
dfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayefvkerR..piispn

subfamily_DSP1_pd Subfamily DSP1 502-562 3.7e-07 24.4 In-house 86-144 (163) alignment
Range on Protein: 502-562
Range on HMM: 86-144/163.0
SFLEITEKCTGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARPgsVIGPQQT
 |..  .|. |   .||.||. |  .|.  |.||. |..  |   . .  |.  .| |  .
efidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRs..iisPnag

subfamily_DSP19_pd Subfamily DSP19 502-554 7e-07 23.7 In-house 80-132 (152) alignment
Range on Protein: 502-554
Range on HMM: 80-132/152.0
SFLEITEKCTGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARPG
 |.| . .  |. .|||.||  |. |..  |.||. . .  |..  .| ||| 
dFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearpc

subfamily_DSP8_pd Subfamily DSP8 502-553 4.5e-06 20.3 In-house 84-135 (159) alignment
Range on Protein: 502-553
Range on HMM: 84-135/159.0
SFLEITEKCTGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARP
.|.. . .  |. .||. ||  |  ... .|.||. ...  |.  ...  ||
efidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrp

subfamily_Slingshot_pd Subfamily Slingshot 503-564 3.2e-07 23.9 In-house 88-147 (169) alignment
Range on Protein: 503-564
Range on HMM: 88-147/169.0
FLEITEKCTGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARpgSVIGPQQTYL
|.| . |    ..|||| |. |. | .  | ||.|...  |......  |  ||| | ...|
fiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerr..svikPnkgfl

subfamily_DSP10_pd Subfamily DSP10 503-560 1.8e-06 21.9 In-house 84-139 (159) alignment
Range on Protein: 503-560
Range on HMM: 84-139/159.0
FLEITEKCTGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARPgsVIGPQ
|.|   |.  . .|||.||. |  ...  |.||| . .  .   . . .||  .| | 
fieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrp..iisPn

Y_phosphatase Protein-tyrosine phosphatase 503-561 3.6e-06 21.9 Pfam-A 158-225 (235) alignment
Range on Protein: 503-561
Range on HMM: 158-225/235.0
FLEITE----KCTGTAVVHCKAGLGRTGSLIGCYMM-KHY----RFNAPETIAWLRIARPGSVIGPQQ
...  |    ...|  ||||.|| ||||...   .. ..      ..  ...  ||  |||.|   .|
lirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleq

Y_phosphatase Protein-tyrosine phosphatase 503-561 3.6e-06 21.9 In-house 158-225 (235) alignment
Range on Protein: 503-561
Range on HMM: 158-225/235.0
FLEITE----KCTGTAVVHCKAGLGRTGSLIGCYMM-KHY----RFNAPETIAWLRIARPGSVIGPQQ
...  |    ...|  ||||.|| ||||...   .. ..      ..  ...  ||  |||.|   .|
lirkvekskeaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdvlqivkelRkqRpgmvqsleq

subfamily_DSP12_pd Subfamily DSP12 503-553 4.1e-06 21.3 In-house 74-124 (155) alignment
Range on Protein: 503-553
Range on HMM: 74-124/155.0
FLEITEKCTGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARP
|.| . .  |. .|||.||. |  ...  |.||.....  . .  .. ..|
FieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkp

DSPc_SM00195 504-561 1.1e-06 23.5 In-house 188-250 (263) alignment
Range on Protein: 504-561
Range on HMM: 188-250/263.0
LEITEKCTGTAVVHCKAGLGRTGSLIGCYMM-----KHYRFNAPETIAWLRIARPGSVIGPQQ
 . ... .|. ||||.||.||||...   ..     .. ...  |..  ||  |||.|   .|
kkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleq

PTPc_SM00194 504-561 1.1e-06 23.5 In-house 188-250 (263) alignment
Range on Protein: 504-561
Range on HMM: 188-250/263.0
LEITEKCTGTAVVHCKAGLGRTGSLIGCYMM-----KHYRFNAPETIAWLRIARPGSVIGPQQ
 . ... .|. ||||.||.||||...   ..     .. ...  |..  ||  |||.|   .|
kkskstssgpivVhCsaGvgRtgtfvtidiilskleeekkvdifeivkelRkqRpgmvqtleq

PTPc_DSPc_SM00012 505-556 1.6e-07 26.8 In-house 27-90 (105) alignment
Range on Protein: 505-556
Range on HMM: 27-90/105.0
EITEKC------TGTAVVHCKAGLGRTGSLIGCYMMKHYR------FNAPETIAWLRIARPGSV
. ..|.      ..  ||||.|| |||| ..  ... .        ..  ...  ||  |||.|
ravkknknksesskpvvVhCsaGvgRtgtfvaldillqqleketkevdifqivkelrkqRpgmv

subfamily_DSP14_pd Subfamily DSP14 508-558 1.2e-06 22.6 In-house 80-128 (157) alignment
Range on Protein: 508-558
Range on HMM: 80-128/157.0
EKCTGTAVVHCKAGLGRTGSLIGCYMMKHYRFNAPETIAWLRIARPgsVIG
.|  | ..|||.||  |  ||   |.||. . .  |.  ... |||  .| 
kkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRp..iir