Gene MbreMKP-Un-4 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP_MKP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP005_AA protein Get Run
MbreP005_AA_186-330 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 21-144 4.5e-12 38.5 Pfam-A 2-111 (113) alignment 
Range on Protein: 21-144
Range on HMM: 2-111/113.0
PEELMGLMetDTDRLVVLDVRPYSDYVVGHIKNAFTLRFSSIllrrlrqNKVSVLDLLIDEASQCIFRERTSRPHAVIVVYDnntteldISEPDHRNSLH
..||  |.  . ...|.||||. ..|  |||..|  ....|.       .. . |    ..|...  ...   ..  .|||.        |  . ..  .
akelkell..ekekvvllDvRspeeyakghIpgAvnvpldsl.......yprrdlffkdklaeeleesgkkldkdktvvvyc.......rsgnrsggaaa

VTVQHLLNS-NY-HVRFLRGGFNGFQ
. ....|..  |  |..|.|||....
lllalilkelgyknvyvLdGGfeawk
0049772 (Phosphotyrosine protein) phosphatases II 149-331 6.3e-30 100.4 In-house 148-278 (314) alignment 
Range on Protein: 149-331
Range on HMM: 148-278/314.0
FCEANPNNtppqaalslsslsldrnmtpstpierhhrdkapaqilpylyvgAEAHAENRELLKrlnvthvlNLTTHDSRKYPE-FGYHQIAIRDsWNQDM
.... .|.                                           .| .|.. ||||        . .. ...   . . |..| . | .... 
llildgng...........................................neptaadlellk........eelydpelferlgikylripvpD.gsapl

SKCFEDAFEYINKCrAEGGCVLLHCVAGISRSAT-VAIAYLMTFRELDLNAAYSTVKERRPcIAPNLDFMGELQRYEEKLAAKRQ
.. |....|.|...  .||.|| || ||..|..| |..||||  . ..|. |.. |...|| | ||  |.  |..||..| |...
ledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefilealle
subfamily_MSG5_pd Subfamily MSG5 169-329 2.7e-15 49.9 In-house 5-163 (165) alignment 
Range on Protein: 169-329
Range on HMM: 5-163/165.0
SLDRNMTPSTPIE-RHHRDKAPAQILP-YLYVGAEAHAEnrELLKRLNVTHVLNLTTHDSRKYPEFGYHQIaiRDSWNQDMSKCFEDAFEYINKCRAEGG
..|... ..  .. |.   . |  .||  ||. .| . .  |||    |  | .  ..   . |   |. |  .   .  . | .    . |   .... 
nedielvhaeildvrrvyldgpllvlpeklylysepklk..ellsfdlvinvakeindlellvpavkyyhi..ewehdskivkdlsrltriihaatskrk

CVLLHCVAGISRSATVAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAK
 .|.||  |.||||.. .||.| . .| |. ||  .| .   |.|.. .. .|  .|  |..|
kilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmewevalskk
0037934 (Phosphotyrosine protein) phosphatases II 171-324 5.1e-27 90.4 In-house 12-239 (243) alignment 
Range on Protein: 171-324
Range on HMM: 12-239/243.0
DRNMTPSTPIERHHRDK---------APAQILPYLYVGAE--------AHAENRELLKRLNVTHVLNLTTH-----------------------------
..|  .. .   | | |            ...|.|...          ..|.. ..|..|..|....||.                              
sknrysdilpydhsrvklegsdyinanliyvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllsee

-----------------DSRKYPEFGYHQIAIRD----SWNQDMSKCFEDAFEYINK-----CRAEGGCVLLHCVAGISRSATVAIAYLMTFR-ELDLNA
                 |  ..  . ||.... |    .  .|. . .... |.|..     .. .|| ||.||.||..|..|...||||  . ..||  
hlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdlee

AYSTVKERRPC-IAPNLDFMGELQRYEE
|. ...|.||. . ......  |.... 
avkllreqRpgkavqtpsqyrflyeall
PTEN_1 172-329 4.5e-33 109.7 In-house 22-194 (196) alignment 
Range on Protein: 172-329
Range on HMM: 22-194/196.0
RNM----------TPSTPIERhhrdkapaQILPYLYVGAEAHA-ENRELLKRLNVTHVLNLTTHDS---RKY-------PEFGYHQIAIRDSWNQDMSKC
. .          .||.|. .        .| . ||.| . .. .... ||  ..|.|.||.  .    | |         . |... |.| . ...|. 
ltyitsriiamgkapsrpllq........eideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslsel

FEDAFEYINKCRA--EGGCVLLHCVAGISRSATVAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAK
|. . . |. ...  .|..|| || ||..||.||..||||  . |. . | . |.|.||..|||  .. .|..|...| |.
fdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfaellae
0042113 (Phosphotyrosine protein) phosphatases II 172-323 1.5e-26 88.8 In-house 12-239 (245) alignment 
Range on Protein: 172-323
Range on HMM: 12-239/245.0
RNMTPSTPIERHHRDKAP------------------AQILPYLYVGAEAHAENRE----LLKRLNVTHVLNLTT--------------------------
.|  .. ..  | | | .                   .| | .....  ..|. |    .|..|..|....||.                          
knrysdilpydhtrvklspdggdldsdyinasyvdgyritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftv

---------------------HDSRKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRA--EGGCVLLHCVAGISRSATVAIAYLM-----TFRELDL
                      |. .   . ||.. . |    |... ..|..|...|..|  ..| || || ||..|..|...||||     . ....|
tllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsl

NAAYSTVKERRPCIAPNLDFMGELQRYE
  |.  ....||.. ......  |....
eeavkelrsqRpgavqtpsqyrflyeal
0045098 (Phosphotyrosine protein) phosphatases II 179-327 1.5e-29 98.7 In-house 12-272 (278) alignment 
Range on Protein: 179-327
Range on HMM: 12-272/278.0
PIERHHRDKAPAQILPYLYVGAEA-----------------------------------------HAENRELLKRLNVTHVLNLTTH-------------
  |. ..   | .|.|.||.|  .                                         .| . ..|. |..|....||.              
efefllllgipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywp

--------------------------------------DS--RKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRA--------------EGGCVLL
                                      |   |.   . |. .   .. .....| | ...|.|.....              .||.|| 
eggsltygdftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlV

HCVAGISRSATVAIAYLMTFR---ELDLNAAYSTVKERRPC-IAPNLDFMGELQRYEEKLA
|| ||..|..|...||||  .    .||  |.......||. . .||...  | ... .| 
HCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell
subfamily_DSP10_pd Subfamily DSP10 181-330 1.4e-52 171.7 In-house 6-157 (159) alignment 
Range on Protein: 181-330
Range on HMM: 6-157/159.0
ERHHRDKAPAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPE--FGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISR
|   . .  .|.||.|..|.|  |.. ..|.|||.|.|||.||.   .. |  . |..| ..|. .|.... ||.|.|.|.. | .|  ||.|| |||||
eadietapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisr

SATVAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAKR
||||.|||||. ..| || ||  |||.|| |.|||.|||.| ..|..|. ..
satvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefekelnksk
subfamily_DSP6_pd Subfamily DSP6 182-328 7.7e-49 159.2 In-house 7-156 (158) alignment 
Range on Protein: 182-328
Range on HMM: 7-156/158.0
RHHRDKAPAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKY---PEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISR
.......|..|||.||.|.. .|.|.|.||.|.. .|||.|..   |.   .|. | ||.|.| ..|...| | .|.|.|.. | .   ||.|| |||||
kkaeaefpveilpllylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisr

SATVAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAA
| ||..||||  ..| || ||  ||.|.. |.||..||| |  .|..|  
svtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldferslrl
0046846 (Phosphotyrosine protein) phosphatases II 182-326 1.2e-31 105.2 In-house 5-172 (176) alignment 
Range on Protein: 182-326
Range on HMM: 5-172/176.0
RHHRDKAPAQILPYLYVGAEA----------HAENRELLKRLNVTHVLNLTTH------------DSRKYPEFGYHQIAIRDSWNQDMsKCFEDAFEYIN
... |  . .|...|..|.            .|.. |.||.|..|.|.|||..            .  . ... |... ..| .  |. . .....|.|.
llgldldldyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefir

KCRAEGGCVLLHCVAGISRSATVAIAYLMTF-RELDLNAAYSTVKERRP-CIAPNLDFMGELQRYEEKL
... |||.|| ||.|||.|..|...|||.   . |... |...|.|.|| .. .. ...  |...| .|
ealkeggpvlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefelll
subfamily_DSP19_pd Subfamily DSP19 184-326 2.4e-41 135.6 In-house 7-150 (152) alignment 
Range on Protein: 184-326
Range on HMM: 7-150/152.0
HRDKAPAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYP-EFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATV
..|.  ... |.||.|.   |...| ||. ..||.||..|.  . .| .| | .| | |  ..|... ...|...|.. | . |.||.|| ||.||||.|
kedlevgeveprlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasv

AIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKL
.|||||. .||.|. |...|.| |||| ||  |.  |..||..|
viaylmkkeelsleealelvrearpcikPneGFikqLkeyeael
0041856 (Phosphotyrosine protein) phosphatases II 184-327 1.5e-33 111.3 In-house 14-173 (182) alignment 
Range on Protein: 184-327
Range on HMM: 14-173/182.0
HRDKAPAQILPYLYVGAEAH--------------AENRELLKRLNVTHVLNLTthDSRKYPEF------GYHQIAIRDSWNQDmskcFEDAFEYINKCRA
...  . .|...||.|.  .              |.. ..||.|..|...|||  . . .||.       |... . |    |    .......|.....
dhsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevle

EGGCVLLHCVAGISRSATVAIAYLMTFRELDLNAAYSTVKERRP--CIAPNLDFMGELQRYEEKLA
|||.|| || ||..|..|...||||  ....|  |...|..|||  .| ||  |.  |. .|..| 
eggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll
subfamily_DSP8_pd Subfamily DSP8 186-329 6.4e-42 136.8 In-house 12-157 (159) alignment 
Range on Protein: 186-329
Range on HMM: 12-157/159.0
DKAPAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHD--SRKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVA
|  | .||..||.|.. .. ..|||..|....|||. ...  . . .|  .... ..|. . ... .|. ..|.|.|...| |.||.|. ||||||||||
dvgptrilknlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatva

IAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAK
|||.|   |..|. ||  |||.|| | ||| |.| |  ||..|  .
iayimktlemsldeayrfvkekrptispnlnflgqLleyekelkll
0044763 (Phosphotyrosine protein) phosphatases II 186-333 6.5e-41 135.3 In-house 20-177 (178) alignment 
Range on Protein: 186-333
Range on HMM: 20-177/178.0
DKAPAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPE----------FGYHQIAIRDSWNQDMSKCFEDAFEYINKCR-AEGGCVLLHCVA
   . .|||.||.|.  .|...||||.|..||..|||. . . ...          . |..| | |. ..|... |....|.|....  .||.|| || |
yinaseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsa

GISRSATVAIAYLMTFRELDLNAAYSTVKERRPcIAPNLDFMGELQRYEEKLAAKRQVK
|..||.|...||||  . |.|..|.. |.|||| | || ...  |...|..| ... ..
GvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllkesdll
subfamily_STYXL1_pd Subfamily STYXL1 186-327 4.3e-25 81.8 In-house 8-154 (157) alignment 
Range on Protein: 186-327
Range on HMM: 8-154/157.0
DKAPAQILP-YLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKY---PE-FGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSA
 . | ..||  ||.| . .| |... | | |  ..|...   . .   ..     .||. |. . |. . ...| ..|.| . || .||.    ||||||
ktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsa

TVAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLA
.|.|||||  ... |. ||. .|. .. . || .|.  |...|..| 
aviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqll
subfamily_MKPLT_pd Subfamily MKPLT 187-329 1.9e-32 106.0 In-house 19-163 (164) alignment 
Range on Protein: 187-329
Range on HMM: 19-163/164.0
KAPAQILP-YLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPE-FGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAI
  |. .|.  || |   ||.|...|| |..||..|...    ..|. . | |. . |  .. .|. .| | ... .    ||.||.||| | |||..|..
iypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtv

AYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAK
|.|....   |. ||. .|||| ..|||  |. .| ..|| .  |
afLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGk
subfamily_MKPLV_pd Subfamily MKPLV 187-329 1.9e-32 106.0 In-house 19-163 (164) alignment 
Range on Protein: 187-329
Range on HMM: 19-163/164.0
KAPAQILP-YLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPE-FGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAI
  |. .|.  || |   ||.|...|| |..||..|...    ..|. . | |. . |  .. .|. .| | ... .    ||.||.||| | |||..|..
iypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtv

AYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAK
|.|....   |. ||. .|||| ..|||  |. .| ..|| .  |
afLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGk
subfamily_Slingshot_pd Subfamily Slingshot 188-332 3.6e-37 121.3 In-house 18-163 (169) alignment 
Range on Protein: 188-332
Range on HMM: 18-163/169.0
APAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPE-FGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAY
....|  ..|.|.|  | | | ||. .|...||.|      .|| | |..| . |. ..|. | .......|.|....|  ||.||  |.||||.. |||
saskifdhvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviay

LMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAKRQV
 |   .|.|. |.. ||||| .| ||  |.  |. ||  | |..| 
amkeyglsleealeyvkerrsvikPnkgflkqleeyeGileaskqr
subfamily_LRR-DSP_pd Subfamily LRR-DSP 188-327 8.8e-33 107.5 In-house 119-259 (263) alignment 
Range on Protein: 188-327
Range on HMM: 119-259/263.0
APAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPE-FGYHQI-AIRDSWNQDMSKCFEDAFEYINKCRAEGGcVLLHCVAGISRSATVAIA
 | .|.. |..|.   | |. .|| |.|||.|   ..    .|. | |  |  |.|  . |.|. ||.   .|.. | .|| ||.|| ||.|||.|. |.
vPdeiidklflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstlvis

YLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLA
|||  ..| .. |.  |...|| | ||  |.  |..||.|| 
ylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyekklf
subfamily_DSP1_pd Subfamily DSP1 189-330 3.2e-45 148.1 In-house 17-160 (163) alignment 
Range on Protein: 189-330
Range on HMM: 17-160/163.0
PAQ-ILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYP-EFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAY
| . ||..||.|.| .| |.|.||.|..|..||.... .  ..  | |... ..|| ..|.|. ||.. |.|.......| ||.|| ||||||.|. .||
PvekildfLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlclay

LMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAKR
||. ... |. |.  ||.||..| ||. |...| .||.|| .. 
lmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekklllel
PTPc_motif_SM00404 189-325 7.9e-43 140.7 In-house 2-140 (140) alignment 
Range on Protein: 189-325
Range on HMM: 2-140/140.0
PAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSR--KYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAY
| .|||.||.| . .|.|..||| |..|||.|.|.  |   . ..| . || ..|. ....|| .. . ..|......|| || || ||.|||||..|||
psrilphlylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaY

LMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEK
||. |.|.|..||. ||||||.| ||| |. .|. ||.|
lmryrqlslaeayefvkerRpiispnlnfvrqLieyekk
0048179 (Phosphotyrosine protein) phosphatases II 189-326 3.2e-35 116.3 In-house 4-144 (144) alignment 
Range on Protein: 189-326
Range on HMM: 4-144/144.0
PAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPEF---GYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIA
|..|||.||.|   .|.. ||||.|..|.|.|||..    ..|.    |... . |    |... .....|.|.....|||.|| || ||..|..|...|
pseilpglylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaa

YLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKL
|||  . |.|. |.  |..|||.. || ...  |..||..|
ylmkklglsleealalvrsrrpgavpnpgqlrfLleyekll
0048076 (Phosphotyrosine protein) phosphatases II 189-326 1.1e-34 114.5 In-house 4-142 (145) alignment 
Range on Protein: 189-326
Range on HMM: 4-142/145.0
PAQILPYLYVGAEAHAENRELLKRLNVTHVLNLtTHDSRKYPE--FGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAY
|..|||.||.|   .|...||||.|..|.|||| |.. . . .  . |... . |   .|... .....|.|.....|||.|| || ||..|..|...||
pseilpglylgslptaldlellkdlgittvlnl.tselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaay

LMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKL
||  . ..|  |.  |...||.. || ...  |...|..|
lmlllgvsleealelvrsqrpgavpnpgqlrflyefelel
0043147 (Phosphotyrosine protein) phosphatases II 189-326 3.1e-34 113.6 In-house 19-160 (172) alignment 
Range on Protein: 189-326
Range on HMM: 19-160/172.0
PAQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTH----DSRKYPEFGYHQIAIRDSWNQdMSKCFEDAFEYINK--CRAEGGCVLLHCVAGISRSATV
| ......... . .|.....||.|..||..|||..    .  .   . |. . . | . . ... .....|.|..  .. .||.|| ||.||..|..|.
pdrfiatqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtl

AIAYLMTfRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKL
..||||  . |.|  |...|.|.||.. .| ...  |. .|..|
vaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfekll
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 189-324 2.2e-29 95.9 In-house 7-145 (148) alignment 
Range on Protein: 189-324
Range on HMM: 7-145/148.0
PAQILP-YLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPEFG--YHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIA
|..| . .|..|.  .| . | || |.||.. | |      . . |  | ..|..|  ..|.|. |||. ....| ..||. ||.|.  |.|||. .|..
pseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalall

YLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEE
.|. |..  |. |.  ||..|. . ||| |.  |. .|.
wlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_DSP14_pd Subfamily DSP14 190-333 5.4e-41 134.2 In-house 8-151 (157) alignment 
Range on Protein: 190-333
Range on HMM: 8-151/157.0
AQILPYLYVGaEAHAENRELLKRLNVTHVLNLTT-HDSRKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAYLM
.|| |.|...  . | ..||||. ..|...|.|.   ..|.... . .....|. .....| |. . ..|.. ...||..|.|||||.||||....||||
sqitpsLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylm

TFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAKRQVK
 ...| |. ||..||..|| | ||. |  .|..||.|| .|  ||
kyeklsLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvk
0049260 (Phosphotyrosine protein) phosphatases II 190-326 8.2e-32 105.4 In-house 9-149 (152) alignment 
Range on Protein: 190-326
Range on HMM: 9-149/152.0
AQILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYP----EFGYHQIAIRDSWNQDMSKCFEDAFEYINK-CRAEGGCVLLHCVAGISRSATVAI
 ........| . .|.. ..||.|..|....||... ....     . |... . |.. .|.| ....... |.| .. .||.|| ||.||..|..|...
fefiatqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlva

AYLMTfRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKL
||||  . ..|  |.. |.|.||.. || ...  |. .|..|
aylml.lgvsleeavalvrekRpgavpnpgqlrflyefekll
subfamily_STYX_pd Subfamily STYX 190-333 1.4e-21 70.3 In-house 13-164 (166) alignment 
Range on Protein: 190-333
Range on HMM: 13-164/166.0
AQILPYLYVGAEAHAENR--ELLKRLNVTHVLNLTTHDSRK-----Y-PEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSAT
 .||| |..|  . | .   | ||.  .||.. .      .     .  .| |  . . |.  ... . .    |.|...  .|| ||.|  |||||||.
qeilpglflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaa

VAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAKRQVK
. |||.|    |    |.  |.||| ||.||  |. .|. ||    || ..|
lviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeaiylakltik
0036941 (Phosphotyrosine protein) phosphatases II 190-333 9.2e-21 69.8 In-house 20-283 (297) alignment 
Range on Protein: 190-333
Range on HMM: 20-283/297.0
AQILPYLYVGAEAHAENRELLK----------------------------------------------------------RLNVTHVLNLTTHDSR----
 ..||.|. |   .|.. | |.                                                           .|||....||. ...    
eellpllllgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrek

--------------------------------------------KYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRA------EGGCVLLHCVAGIS
                                            . ...  ... . .    ..  .... ...|...|       .|| || ||.||..
caqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvg

RSATVAIAYLM--------TFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAKRQVK
||.|...|.||        . ...|.  |. ...|.||.. ..|...  | ... .|  |. .|
RsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkkkltk
subfamily_DSP15_pd Subfamily DSP15 191-329 2.7e-38 125.4 In-house 4-142 (151) alignment 
Range on Protein: 191-329
Range on HMM: 4-142/151.0
QILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAYLMTF
..|| ||.|    ....||||. |.||.|..     .  ... |. ||. |. ....|| |... |.| ||| ... ||.||.||.|||.|...||||| 
kvlpglylgnfrdskdeelLkeknithilsvhdnakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtv

RELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAK
 ||. . | ...|..| .  ||. |   |. ||.. ...
telnwrdalevikaaRsvanPnfGfkrqlkeyektklke
subfamily_DSP12_pd Subfamily DSP12 191-325 2.8e-33 109.5 In-house 4-142 (155) alignment 
Range on Protein: 191-325
Range on HMM: 4-142/155.0
QILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHDS----RKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAY
.||| ||.|  ..... |||| |..|||| .....      |  .  . .| |.|. ..|. . ...|...|.....|.| || || ||.|||.|. |||
rilpglylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAY

LMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEK
||   .|.|. |...||| .| | ||  |.  |. .|. 
lmkkeklslekAlklvkekkpeiepNegFleQLklfekm
subfamily_DSP3_pd Subfamily DSP3 191-330 3e-33 108.8 In-house 13-161 (162) alignment 
Range on Protein: 191-330
Range on HMM: 13-161/162.0
QILPYLYVGAEAHAENRELLKRLNVTHVLNLTTH-------DSRKYP--EFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRA-EGGCVLLHCVAGISRSA
.. | |||| || |.... ||.| .||||| .         ..  |   |. |. . ..|. . |.|| || |...|..  . . | ||.|||.|.||||
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

TVAIAYLMTFRELDLNAAYSTVKERRpCIAPNLDFMGELQRYEEKLAAKR
|...|||| .|...|. | .||...| .| ||  |.  |. ..|.|. |.
tlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldeelkrkk
0036282 (Phosphotyrosine protein) phosphatases II 191-325 1.2e-27 92.1 In-house 14-168 (174) alignment 
Range on Protein: 191-325
Range on HMM: 14-168/174.0
QILPYLYVGAEAHAeNRELLKRLNVTHVLNLTTHDSR----------------KYPEFGYHQIAIRDSWNQDMSKcFEDAFEYINKCRAE--GGCVLLHC
 |.|.|..|.  .| . |.||.|..|.|..|..   .                .   . |... . |    |.|. .............|  ||.|| ||
yitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHC

VAGISRSATVAIAYLMTFREL-DLNAAYSTVKERR---PCIAPNLDFMGELQRYEEK
 ||..|..|...||||  . | .|  |...|.|.|   |.. .. ...  |. .| .
saGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl
0051082 (Phosphotyrosine protein) phosphatases II 191-319 2.6e-25 84.2 In-house 10-146 (151) alignment 
Range on Protein: 191-319
Range on HMM: 10-146/151.0
QILPYLYVGAEAHAENRELLKRLNVTHVLNLTTHD-----SRKYPE--FGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAE-GGCVLLHCVAGISRSATV
.. ..||...  .|.. ||||.|......||.. .      . .||  . ...| | | ...... .|. . |.......  .|.|| || ||..|..|.
yvtgglyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtl

AIAYLMTfRELDLNAAYSTVKERRP-CIAPNLDFMGEL
...|||  . ..|..|.. ....|| .. ||  |. .|
valylml.lgvsleealeeyrlkrpgvvqpnqqflfql
0040439 (Phosphotyrosine protein) phosphatases II 193-325 1.3e-26 89.1 In-house 33-244 (249) alignment 
Range on Protein: 193-325
Range on HMM: 33-244/249.0
LPYLYVG------------------------AEAHAENRELLKRLNVTHVLNLTTHDS------------------------------------------
|| |. .                         |. . ....|..|..|....||. .                                           
lpglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtlelt

--RKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRA------EGGCVLLHCVAGISRSATVAIAYLM-----TFRELDLNAAYSTVKERRPCIAPNL
   . ... ...| . |   .. .. |||....|...|       .||.|| || ||..|..|...||||     . ...||  |.......||.. .|.
nlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnp

DFMGELQRYEEK
...  |.... .
eqyrflyealle
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 194-326 6.2e-24 78.1 In-house 8-152 (154) alignment 
Range on Protein: 194-326
Range on HMM: 8-152/154.0
PYLYVGAEAHAENRELLKRLNVTHVLNLTTHDSRKYPE----------FGYHQIAIRDSWNQDMSKCFEDAFEYINKCR--AEGGCVLLHCVAGISRSAT
 .||...   | |. .|.  |....||  .  .  ...          . | .. . |  |.|. . .. |||.|..     | . ||.|. .|.||||.
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

VAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKL
..|.|||  ... |  |.  .|. |. | ||  |.  |...| .|
llisylmdklkislslalellkdsryiikPnqGflkqleifekel
DSPc Dual specificity phosphatase, catalytic domain 196-324 3.8e-37 122.1 Pfam-A 1-132 (133) alignment 
Range on Protein: 196-324
Range on HMM: 1-132/133.0
LYVGAEAHAEnRELLKRLNVTHVLNLTTHDS----RKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAYLMTFR
||.|.. .|.  .||. |..|.|.|.|.. .    .| .|. | .| ..|......|| .|.| |.|.|....|. || || ||||||||..|||||. .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

ELDLNAAYSTVKERRPCIAPNLDFMGELQRYEE
.|.|| ||. |||||..| ||  |...|  ||.
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 196-324 3.8e-37 122.1 In-house 1-132 (133) alignment 
Range on Protein: 196-324
Range on HMM: 1-132/133.0
LYVGAEAHAEnRELLKRLNVTHVLNLTTHDS----RKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAYLMTFR
||.|.. .|.  .||. |..|.|.|.|.. .    .| .|. | .| ..|......|| .|.| |.|.|....|. || || ||||||||..|||||. .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

ELDLNAAYSTVKERRPCIAPNLDFMGELQRYEE
.|.|| ||. |||||..| ||  |...|  ||.
nlslneAyefvkerrskispnagflrqLleyer
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 196-328 3.2e-22 72.2 In-house 6-143 (145) alignment 
Range on Protein: 196-328
Range on HMM: 6-143/145.0
LYVGAEAHAENRELLKRLNVTHVLNLTTHDS-----RKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAYLMTF
||||.  ||..  .|. | .. ..|... ..      |  ..    |.  |    |.|. |..  ..|.| . ||  |..||.||.||| ||..|.|| .
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

RELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAA
 .. |  |   |. .|    ||. |. .| . | .|  
cnmtlseaarqvrsnrllaypnvtflknllnlekqlke
0051429 (Phosphotyrosine protein) phosphatases II 196-327 5.8e-22 74.1 In-house 24-225 (272) alignment 
Range on Protein: 196-327
Range on HMM: 24-225/272.0
LYVGAEA---HAENRELLKRLNVTHVLNLTTHD-------SRKYPEFGYHQIAIRDSWNQDMS-------------------------------------
|| ..      |.. . ||.|.......|.. .       .|  | . |... | |.  ....                                     
lyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevm

--------------KCFEDAFEYINKcraeGGCVLLHCVAGISRSATVAIAYLMTfRELD--------------LNAAYSTVKERRPCIAPNLDFMGELQ
              . . ...|....    || || || ||..|..||. ..|.  . ..              | .|.. ....||.. .. ...  |.
hlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylfly

RYEEKLA
... .|.
eallell
0039614 (Phosphotyrosine protein) phosphatases II 207-326 1.9e-23 78.8 In-house 118-288 (297) alignment 
Range on Protein: 207-326
Range on HMM: 118-288/297.0
RELLKRLNVTHVLNLTTHDSRKY--------------------P-----------------------EFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRA
 .......||....||. . ..                                                .. . . |    . .. . ...|......|
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

---EGGCVLLHCVAGISRSATVAIAYLM-----TFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKL
   .||.|| ||.||..|..|...||||     . ...|.  |.....|.||.. ......  |.... .|
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0043336 (Phosphotyrosine protein) phosphatases II 207-323 1.5e-18 62.7 In-house 105-273 (278) alignment 
Range on Protein: 207-323
Range on HMM: 105-273/278.0
RELLKRLNVTHVLNLTTHDSRK----------------------------------------------YPEFGYHQIAIRDSWNQ-DMSKCFEDAFEYIN
..... |.||....||. . ..                                              .   .|| ... |     ..|  ..   . ..
wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavre

KCRAEGGCVLLHCVAGISRSATVAIAYLM-----TFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYE
... ..|.|| ||.||..|..|....||.     . ...||  |.....|.||.. ......  | ...
aledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal
0045450 (Phosphotyrosine protein) phosphatases II 208-325 4.6e-24 81.1 In-house 125-302 (307) alignment 
Range on Protein: 208-325
Range on HMM: 125-302/307.0
ELLKRLNVTHVLNLTTHDSR-----------------------------KYPEFGYHQIAIRDS-----------------WNQDMSKCFEDAFEYINKC
..|....||....||. . .                             ..... .... . |.                  ... .. ||.... |...
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

RA------EGGCVLLHCVAGISRSATVAIAYLMTFRE--------LDLNAAYSTVKERRPCIAPNLDFMGELQRYEEK
|.      .||.|| || ||..|..|...||||  .         .||  |.....|.||.. .|....  |.... .
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0040438 (Phosphotyrosine protein) phosphatases II 208-330 3e-22 74.7 In-house 104-279 (317) alignment 
Range on Protein: 208-330
Range on HMM: 104-279/317.0
ELLKRLNVTHVLNLTTHDSR----------------------------KYPEFGYHQIAIRDS----------------WNQDMSKCFEDAFEYINKCRA
.......||....||. . .                            ..... .... . |.                  ..  . ... .. ....|.
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

E----GGCVLLHCVAGISRSATVAIAYLM-----TFRELDLNAAYSTVKERRPCIAPNLDFMGELQRYEEKLAAKR
     ||.|| ||.||..|..|...||||     . ...|.  |. ...|.||.. ......  | ... ..  ..
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleylkrk
subfamily_DSP23_pd Subfamily DSP23 208-308 7.1e-07 24.0 In-house 25-127 (148) alignment 
Range on Protein: 208-308
Range on HMM: 25-127/148.0
ELLKRLNVTHVLNLTTH---DSRKYPEFGYHQIAIRDSWNQDMsKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAYLMTFRELDLNAAYSTVKE
. |  | | ... ||..   ..   |.  .... | |     . .  ..  . ...  . .  | .||. |  |. |.   ||.  |.|    | . |..
rylldlgvrylvslteegrphveatpnltlvrlriddyhppal.eqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrr

RRPC
.|| 
lrpg
0038934 (Phosphotyrosine protein) phosphatases II 212-326 1.7e-19 65.7 In-house 54-176 (194) alignment 
Range on Protein: 212-326
Range on HMM: 54-176/194.0
RLNVTHVLNLT----THDSRKYPE--FGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAE--GGCVLLHCVAGISRSATVAIAYLMTFRELDLNAAYSTVK
  ....|..||    . | .....  . |... . | ..    .   . .. ...  .|  ||.|. ||.||..|..|...|||.  . .....|. ...
nvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfr

ERRPCIAPNLDFMGELQRYEEKL
|.|| . || |.. .|... . |
ekRpgaipnqdyleallkrykel
0050432 (Phosphotyrosine protein) phosphatases II 214-314 6.5e-12 40.9 In-house 132-286 (308) alignment 
Range on Protein: 214-314
Range on HMM: 132-286/308.0
NVTHVLNLTTHDSR---------------KYPEFGYHQ-----------------------------------IAIRDSWNQDMSKCFEDAFEYINKCRa
||...  ||. . .               .. |.|. .                                   ..  |    .  . . | .|...|.. 
nvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.

EGGCVLLHCVAGISRSATVAIAYLM-----TFRELDLNAAYSTVKERRPCIAPNLD
.|| .. || ||..|..|.....|.     . ...|.  |. ...|.||.  ....
pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtpe
0047943 (Phosphotyrosine protein) phosphatases II 215-316 2.4e-14 48.9 In-house 102-261 (273) alignment 
Range on Protein: 215-316
Range on HMM: 102-261/273.0
VTHVLNLTTHDSRK----------------------------------------------YP-EFG---YHQIAIRDSWNQDMSKCFEDAFEYINKCRA-
|...  ||. ....                                              .. ..    .|   . |    .  . . . .|...|... 
vrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkalea

--EGGCVLLHCVAGISRSATVAIAYLM-----TFRELDLNAAYSTVKERRPCIAPNLDFM
  ..| |. ||.||..|..|.....|.     . ...|.  |.  ....||.. ......
lpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqy
subfamily_PTPMT1_pd Subfamily PTPMT1 216-328 2.2e-18 61.3 In-house 48-170 (171) alignment 
Range on Protein: 216-328
Range on HMM: 48-170/171.0
T--------HVLNLTTHDSRKYPEFGYHQ--IAIRDSWNQDMSKCFEDAFEYINKCRAEGGCVLLHCVAGISRSATVAIAYLMTFRELDLNAAYSTVKER
         . |.. .  .... . | .|  .|. |  ..   .  |.. |.|.| . .| .| .|| || .||||....|||. ..|... | ...|..
kavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkk

RPCIAPNLDFMGELQRYEEKLAA
|. |  .   .  ||.||||| .
Rkiirlakkqwkalqeyeeklls
0051299 (Phosphotyrosine protein) phosphatases II 217-314 1.7e-12 42.9 In-house 119-273 (288) alignment 
Range on Protein: 217-314
Range on HMM: 119-273/288.0
HVLNLTT---------------------------------------------------HDSRKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKC-RAE
..  ||.                                                    |. ..    .| ... |    |  . . |  ....|. .. 
vIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasg

GGCVLLHCVAGISRSATVAIAYLM-----TFRELDLNAAYSTVKERRPCIAPNLD
||.|. || ||..|..|.....|.     . ...|.  |. ...|.||.. ....
ggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe
0046845 (Phosphotyrosine protein) phosphatases II 219-314 6.5e-12 40.9 In-house 153-261 (284) alignment 
Range on Protein: 219-314
Range on HMM: 153-261/284.0
LNLTTH--DSRKYPEFGYHQIAIRDSWNQDMSKCFEDAFEYINKCRAE---GGCVLLHCVAGISRSATVAIAYLMTFR--------ELDLNAAYSTVKER
| || .  ..  .    .| ... |    . .. . . ........ .   || .. || ||..|..|.....|.  .        ..|.  |.. ..|.
leltnlgytgesrtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreq

RPCIAPNLD
||.   .|.
Rpgmvqtle
subfamily_RNGTT_pd Subfamily RNGTT 231-327 2.3e-07 24.7 In-house 77-176 (189) alignment 
Range on Protein: 231-327
Range on HMM: 77-176/189.0
EFGYHQIAIR---DSWNQDMSKCFEDAFEYINKcRAEGGCVLLHCVAGISRSATVAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFMGEL-QRYEEKL
.  |......   .. ...  | |    |  .| .     . .||  |  |.  ....||.  .. ...|| .. .. ||    . |.. || .||..  
gikyvklqcagkgeaPeaeqvkefiklveeffk.knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkellrrYadve

A
.
e
PTPc_DSPc_SM00012 251-288 8.1e-06 21.4 In-house 22-62 (105) alignment 
Range on Protein: 251-288
Range on HMM: 22-62/105.0
FEDAFEYINKCRAE---GGCVLLHCVAGISRSATVAIAYLM
. .......|.. .   .. |..|| ||..|..|.. ....
ilellravkknknksesskpvvVhCsaGvgRtgtfvaldil
0048567 (Phosphotyrosine protein) phosphatases II 254-316 4.1e-06 21.3 In-house 63-128 (157) alignment 
Range on Protein: 254-316
Range on HMM: 63-128/157.0
AFEYINKCRAEGGCVLLHCVAGI---SRSATVAIAYLMTFRELDLNAAYSTVKERRPCIAPNLDFM
. .... .. .|. . .|| ||    .|.||.. .||.    .. . |.  ..  || . |  | .
lnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdas