Gene MbreMKP-Un-5 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP_MKP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP006_AA protein Get Run
MbreP006_AA_74-221 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
WVELL WVELL protein 19-58 3.3e-06 13.2 Pfam-A 2-41 (75) alignment 
Range on Protein: 19-58
Range on HMM: 2-41/75.0
DWLDDLADDMPEDDYDMEIEEAISWEQSLAEDFQMHVAKA
. |. |.. . |    .. .||  |   | |||.   |||
eylerLteeLlekNeklsyaeArtWvElLWeDFeatyAKa
subfamily_DSP6_pd Subfamily DSP6 69-219 8.7e-27 87.6 In-house 6-153 (158) alignment 
Range on Protein: 69-219
Range on HMM: 6-153/158.0
QRPDNACGPADILPQLCLGDASHALDVEQLRRAGVSGVVNCAESatLSSRSDYPAEWEYLGFDAQDHSHYDMlGNHFEQVAAFIDAAAAAKRKVLIHCQA
..  .|. |..|||.| || | .| ..| |.. ... |.| ..   | .  .   | .||   ..|| . ..  ..| .  .||| |  .| |||.|| |
lkkaeaefpveilpllylGsakdasnlevlkklkikyvlnvtsn..lpnkfeesgelkylqipiedhlsqnl.akffPeaiefidearskkskvlvhCla

GVNRSAMIVVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAHE
|. ||  ...|| | ...  |  | |   .... |  |  |..||. | ..
GisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfers
PTEN_1 72-219 2.6e-21 71.3 In-house 36-190 (196) alignment 
Range on Protein: 72-219
Range on HMM: 36-190/196.0
DNACGPADILPQLCLGDASHA-LDVEQLRRAGVSGVVNCAESATLSSRSD-----YPAEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAAAA--KRKVL
 .  ..  | ..| .| ....  |...|   |. .||| .|   ||.||.     .    ||| |. .||   ..   .|. .. ||... ..  ...||
psrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapsls.elfdicksfiewllsdpngnvVl

IHCQAGVNRSAMIVVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAHE
.||.||..||...| || | .       ||.. ...||..  | .. |.|. . .|
VHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfae
0041856 (Phosphotyrosine protein) phosphatases II 73-217 2.6e-26 87.7 In-house 15-169 (182) alignment 
Range on Protein: 73-217
Range on HMM: 15-169/182.0
NACGPADILPQLCLGDASH--------------ALDVEQLRRAGVSGVVNCAesatlsS-----RSDYPAEWEYLGFDAQDHSHYDmlgnhFEQVAAFID
.  ..  |.. | ||.  .              | ....|.. |.. .||..      .        . . ..|| .   ||.  |     .... .||.
hsrdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt......eelywpellerlgiqylylpwpDhgvpd.....ldelldfie

AAAAAKRKVLIHCQAGVNRSAMIVVAYYMLSTHTPLLAALDHCARQRP--CILRNVGFIEQLVVFA
.. . ...||.|| |||.|....|.||.|.. . .|  |...  ..||  .|  | .|..||... 
evleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlalle
subfamily_DSP10_pd Subfamily DSP10 74-219 1.1e-27 90.9 In-house 11-152 (159) alignment 
Range on Protein: 74-219
Range on HMM: 11-152/159.0
ACGPADILPQLCLGDASHALDVEQLRRAGVSGVVNCAESATLSSRSdypAEWEYLGFDAQDHSHYDmLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRS
.   ...|| | ||..  | | . |.| ... |.| . |    ..    .. .|   ...| |. . | ..||.  .||. |    ..||.|||||. ||
tapasqvlpfLflGsekdaadldaldrlnitavlnvttsvPnefee...ealkYkripvsDtskqn.lkqyfeealefieearkkgsrvLvhCqaGisrs

AMIVVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAHE
| .|.|| |  ..  |  | ..   .|| |  |..|. ||. | .|
atvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefeke
subfamily_DSP8_pd Subfamily DSP8 74-219 1.4e-21 70.7 In-house 12-153 (159) alignment 
Range on Protein: 74-219
Range on HMM: 12-153/159.0
ACGPADILPQLCLGDASHALDVEQLRRAGVSGVVNCAESATlssRSDYPAEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRS
. ||  ||..| ||   ..|. | |.. |.| |.|  .|     ...   | ..|    .|. . ..| . |..   ||| | ... .||.|. ||  ||
dvgptrilknlylGsqkdvlseellsklgisyvlnasnscp...kleelkeskflrvPvkDkydekll.pwfdksvefidkaksengrvlvhvlaGisrs

AMIVVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAHE
| ...|| |   .  |  |  .   .|| | .|. |..||. . .|
atvaiayimktlemsldeayrfvkekrptispnlnflgqLleyeke
0043147 (Phosphotyrosine protein) phosphatases II 76-217 2.2e-26 88.1 In-house 18-157 (172) alignment 
Range on Protein: 76-217
Range on HMM: 18-157/172.0
GPADILPQLCLGDASHALDVEQLRRAGVSGVVNCAeSATLSSRSDYPAEWEYLGFDAQDHSHYdmLGNHFEQVAAFIDA--AAAAKRKVLIHCQAGVNRS
 | .... . ...  .| ....|.. |.. .||.  . ..     ..  ..|| .   ||.    | ......  |||   |   . .||.|| |||.|.
ipdrfiatqgplrntladfwrmlkelgithivnlt.ellydpellerlgiqylylpwpDhgvp..llellleflefidellalspggpvlVHCsaGvgRt

AMIVVAYYMLsTHTPLLAALDHCARQRPCILRNVGFIEQLVVFA
...|.||.||  . .|. |...  ..||..  | ... .|  |.
gtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfe
0036282 (Phosphotyrosine protein) phosphatases II 76-215 2.2e-21 71.8 In-house 11-164 (174) alignment 
Range on Protein: 76-215
Range on HMM: 11-164/174.0
GPADILPQLCLGDASHAlDVEQLRRAGVSGVVNCAESATLS-----------SRSDYPAEWEYLGFDAQDHSHYDMLGnhFEQVAAFIDAAAAA--KRKV
.   |.| | .|.. .| ..|.|.. |.. ||.. |.  |            . . ..  ..|| .   ||.  |.    ....  |.. | .   ...|
dlsyitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi..llefvkfveealsedpggpv

LIHCQAGVNRSAMIVVAYYMLSTHT-PLLAALDHCARQR---PCILRNVGFIEQLVV
|.|| |||.|....|.||.||  .  .|  |||. ...|   |..  . .....|  
lVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyy
subfamily_DSP1_pd Subfamily DSP1 77-220 1.1e-30 100.9 In-house 17-156 (163) alignment 
Range on Protein: 77-220
Range on HMM: 17-156/163.0
PAD-ILPQLCLGDASHALDVEQLRRAGVSGVVNCAESatlsSRSDYPAEWEYLGFDAQDHSHYDMlGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAM
|   ||. | || ...| ..|.|.. |.. ..|....        ..  .||     .|... |.   .||.|  |||.. ... |||||||||. ||. 
PvekildfLylGsetvasnleiLkslgitailnvske....ldnvfedlfeYkklkleDspkadi.slvfeeviefidevkkknGkvlihCqaGisRsst

IVVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAHEH
...|| | .... |  | | . ..|..|  |.||. ||. .... 
lclaylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkl
0044763 (Phosphotyrosine protein) phosphatases II 77-220 1.8e-30 101.3 In-house 23-170 (178) alignment 
Range on Protein: 77-220
Range on HMM: 23-170/178.0
PADILPQLCLGDASHALDVEQLRRAGVSGVVNCAESATLSS---RSDYPAE--WEYLGFDAQDHSHYDmLGNHFEQVAAFIDAAA-AAKRKVLIHCQAGV
.  ||| | ||.. .| |.|.|.. |.. .||..|   |        .| |  ..|| .   ||.  | |  ||... .||..|    ...||.||.|||
aseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpd.llehflefvefieealdekggpvlVHCsaGv

NRSAMIVVAYYMLSTHTPLLAALDHCARQRPcILRNVGFIEQLVVFAHEH
.||...|.||.|.. . .| .|...  ..|| |  | |...||  |. ..
gRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrl
PTPc_motif_SM00404 77-216 2.3e-30 100.3 In-house 2-137 (140) alignment 
Range on Protein: 77-216
Range on HMM: 2-137/140.0
PADILPQLCLGDASHALDVEQLRRAGVSGVVNCAESATLSsrsDYPAEWEYLGFDaQDHSHYDMLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMI
|  |||.| || .|.| . ..|   |.. |.|..|. .|.   .   . ..|  . .| .. | | .....|..||..|.. ..|||.||||||.|||..
psrilphlylgskskaqnpallkklgithvinvteevslt...kensgfqilqip.lddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatl

VVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVF
..||.| . .  | .|..   ..||.| .|..|..||. .
iiaYlmryrqlslaeayefvkerRpiispnlnfvrqLiey
0048076 (Phosphotyrosine protein) phosphatases II 77-219 1.7e-28 94.5 In-house 4-141 (145) alignment 
Range on Protein: 77-219
Range on HMM: 4-141/145.0
PADILPQLCLGDASHALDVEQLRRAGVSGVVNCaesaTLSSRSDYPAEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMI
|. |||.| ||.  .|||.|.|.. |.  |.|.    |   .  ..  ..|| ..  ||.  |.| ...... .||..| .....||.||.|||.|....
pseilpglylgslptaldlellkdlgittvlnl....tselellerlgiqylylpwpDhgvpdll.ellleflefieealkeggpvlVHCsaGvgRtgtl

VVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAHE
|.|| ||. . .|  ||..  .|||..  |.|....|  | .|
vaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefele
0048179 (Phosphotyrosine protein) phosphatases II 77-216 1.3e-27 91.7 In-house 4-140 (144) alignment 
Range on Protein: 77-216
Range on HMM: 4-140/144.0
PADILPQLCLGDASHALDVEQLRRAGVSGVVNCAESATLSSRSDYpaEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMI
|. |||.| ||.  .|||.|.|.. |.. |.|..|.    .  ..   ..|| ..  ||.  |.| ...... .||..| . ...||.||.|||.|....
pseilpglylgslptaldlellkklgittvinlteeyepeflere..giqylhlpwpDhgvpdll.ellleflefieealeeggpvlVHCsaGvgRtgtl

VVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVF
|.|| |.  . .|  ||..  ..||..  | |....|  .
vaaylmkklglsleealalvrsrrpgavpnpgqlrfLley
subfamily_Slingshot_pd Subfamily Slingshot 77-216 5.7e-23 75.2 In-house 19-153 (169) alignment 
Range on Protein: 77-216
Range on HMM: 19-153/169.0
PADILPQLCLGDASHALDVEQLRRAGVSGVVNCAESAtlssRSDYPAEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMI
.. |   . ||    | ..|.|.. ||. ..| ..       . .| ..|||     |... |.| .....   ||..| ... |||.||. || ||| .
askifdhvylGsewnasnleelkengveyilnvtkei....dnffpekfeylnirvydeeetdll.kywnetykfiekakkkgskvlvhckmGvsrsast

VVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVF
|.|| | . .. |  ||..  ..| .|  | ||..|| ..
viayamkeyglsleealeyvkerrsvikPnkgflkqleey
subfamily_LRR-DSP_pd Subfamily LRR-DSP 77-218 1.5e-22 73.9 In-house 120-256 (263) alignment 
Range on Protein: 77-218
Range on HMM: 120-256/263.0
PADILPQLCLGDASHALDVEQLRRAGVSGV-VNCAESATLssrsdYPAEWEYLGF-DAQDHSHYDMLgNHFEQVAAFIDAAaAAKRKVLIHCQAGVNRSA
|  |...| ||    | .   |.  ||. . .  |.   |     .|  . ||   |..|  ..|.  .|||.. |||.     |  ||.||.||| ||.
PdeiidklflGgldsannksilkdlgvthillavadfePl.....fPklfkylsiddiedvdeadis.qhfeetnafieeG.rkkGGvlvhcraGvsrss

MIVVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAH
 .|..| |   .  .  |||   ..|| |  | ||..||  . .
tlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
0045098 (Phosphotyrosine protein) phosphatases II 77-220 1.3e-21 72.6 In-house 22-271 (278) alignment 
Range on Protein: 77-220
Range on HMM: 22-271/278.0
PADILPQLCLGDAS-----------------------------------------HALDVEQLRRAGVSGVVNCAESATLS-------------------
| .|.| | ||...                                         .| . ..|.  |.. .|...|   |.                   
pseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdf

--------------------------SRSDYPAEWEYLGFDAQDHSHYDMLG--NHFEQVAAFIDAAAA--------------AKRKVLIHCQAGVNRSA
                            ...... ..| .   .  .   |   ..| ..  ||..| .               . .||.||.|||.|..
tvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtG

MIVVAYYMLST---HTPLLAALDHCARQRPC-ILRNVGFIEQLVVFAHEH
..|.||.||.    .  || |...  .|||. .. | .....|  |. |.
tlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllel
subfamily_STYXL1_pd Subfamily STYXL1 77-216 4.7e-17 55.6 In-house 11-149 (157) alignment 
Range on Protein: 77-216
Range on HMM: 11-149/157.0
PADILP-QLCLGDASHALDVEQLRRAGVSGVVNCAESATLSSRSdYPAEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAM
| ..|| .| ||. ..| . .  .   | ..|| .  |     .  .   . |  . .|. . |.| ......  ||.     .. ||.  . |. ||| 
PvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliag.vadvakllhiavedeneadll.erlkeavqfiekhkkegevvlvfsnkGisrsaa

IVVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVF
...|| | | .. |  |...  . .. .  | .|.|||  .
viiaylmyskkitlkkaykylkkCkenvkPnrafveqlseW
subfamily_DSP19_pd Subfamily DSP19 78-216 5.6e-28 92.2 In-house 13-146 (152) alignment 
Range on Protein: 78-216
Range on HMM: 13-146/152.0
ADILPQLCLGDASHALDVEQLRRAGVSGVVNCAESATLSsrsdYPAEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIV
. . |.| ||  . | | |.|.. ..  ..| |          .| ...||  .  |..  |.| ......  ||. |  ..  ||.||.||| ||| .|
geveprlylgsqdvaadkeilkekkitHilnvatgvpnv....fpkdftylsieilDlpetdll.sylkealdFieearskdgavlvHCnAGvSRsasvv

VAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVF
.|| | .... |  ||. .  .||||  | |||.||  .
iaylmkkeelsleealelvrearpcikPneGFikqLkey
subfamily_DSP14_pd Subfamily DSP14 78-218 6.9e-26 85.1 In-house 8-142 (157) alignment 
Range on Protein: 78-218
Range on HMM: 8-142/157.0
ADILPQLCLGdASHALDVEQLRRAGVSGVVNCAEsaTLSSrsDYPAEWEYLGFDAQDHSHYDmLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIV
. | |.| |. .. ||. |.|...... ..|..    |..      . |..   ..|... . | .||..||. |... ... |.|.|| ||| ||| ..
sqitpsLfls.gvaalskellkkkkitliinvtv..elpn..tklkdiervkvpveDnpeak.lakhfdevadkieevkkkggktlvhCvaGvSRSAslc

VAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAH
.|| |   .. |  |  .   .|| |  |||| .||. . .
laylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEk
0051082 (Phosphotyrosine protein) phosphatases II 78-214 3.7e-19 64.2 In-house 9-147 (151) alignment 
Range on Protein: 78-214
Range on HMM: 9-147/151.0
ADILPQLCLGDASHALDVEQLRRAGVSGVVNCAESATLSsrsDYPAEW-----EYLGFDAQDHSHYDmLGNHFEQVAAFIDAAAAA-KRKVLIHCQAGVN
 .. . | .... .| ..|.|.. |.. .||. .         .|  .     |.| .   |.. .. |  .|..|..|......  . .||.|| ||..
syvtgglyrsggpladflellkelgiktivnlrseeerg...ycpeylpelgievlhipildwpdpg.lplsfdavleflellldkkngpvlvHCsaGkg

RSAMIVVAYYMLsTHTPLLAALDHCARQRP-CILRNVGFIEQLV
|....|..| ||  . .| .||..  ..|| ..  | .|. || 
RTGtlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf
subfamily_DSP3_pd Subfamily DSP3 79-219 3.4e-31 102.1 In-house 13-156 (162) alignment 
Range on Protein: 79-219
Range on HMM: 13-156/162.0
DILPQLCLGDASHALDVEQLRRAGVSGVVNCAESAT--LSS-RSDYP-AEWEYLGFDAQDHSHYDMlGNHFEQVAAFIDAAAAA-KRKVLIHCQAGVNRS
.. |.| .||.. | | ..|...|.  |.|.||.        .. |  .| .|||....|  . |.  ..||..|.|||.| .  . |||.||..|| ||
evypklyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdl.skyFetaakfidealsqkegkvlvhcvvGvsRs

AMIVVAYYMLSTHTPLLAALDHCARQRpCILRNVGFIEQLVVFAHE
| .|.|| |.. .  |  |. . ...| .|| | ||..||. . .|
atlvlayLmirrkmtlveairtvrkkR.eilPneGFlkqLaeldee
subfamily_DSP12_pd Subfamily DSP12 79-218 5e-27 89.2 In-house 4-141 (155) alignment 
Range on Protein: 79-218
Range on HMM: 4-141/155.0
DILPQLCLGDASHALDVEQLRRAGVSGVVNCAESATlSSRSDYPAEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVV
 |||.| ||..... . |.|. .... |.  .. .   . .. . . ...  .. |. . |.| .|.... .||. | . ...||.|||||| ||. ||.
rilpglylggleavqeeellkelkithvlsvikeel.pehklkkgkvstkfiqilDepeediL.shldeavdFieealeeegavlvHCqagvSRSvtivi

AYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAH
|| | ... .|  ||.   ...| |  | ||.||| .| .
AYlmkkeklslekAlklvkekkpeiepNegFleQLklfek
0049260 (Phosphotyrosine protein) phosphatases II 79-216 1.1e-22 75.8 In-house 10-145 (152) alignment 
Range on Protein: 79-216
Range on HMM: 10-145/152.0
DILPQLCLGDASHALDVEQLRRAGVSGVVNCAESATlSSRSDYPAEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDA-AAAAKRKVLIHCQAGVNRSAMIV
 ... . .|. ..| ....|.. |.. .|.. |      .   .  ..|| .   ||. .|.   .....  ||.  |   . .||.|| |||.|....|
efiatqgpgpntladfwrmlkelgittivmltelle.lgklkceqyiqylhlpwpDhgvpdls.qlllflllfieklaldkggpvlVHCsaGvgRtgtlv

VAYYMLsTHTPLLAALDHCARQRPCILRNVGFIEQLVVF
.||.||  . .|. |...  ..||..  | |....|  |
aaylml.lgvsleeavalvrekRpgavpnpgqlrflyef
subfamily_DSP15_pd Subfamily DSP15 79-218 9.4e-22 71.7 In-house 4-137 (151) alignment 
Range on Protein: 79-218
Range on HMM: 4-137/151.0
DILPQLCLGDASHALDVEQLRRAGVSGVVNCAEsatlsSRSDYPAEWEYLGFDAQDHSHYDmLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVV
..|| | ||.   . | |.|..  .. ...  .     .   .  . ||. . |.| .. . | ..|..   || ..   . .||.|| ||| ||. .||
kvlpglylgnfrdskdeelLkeknithilsvhd.....nakkllkdieYkciaasDtpsak.lskffkesvefihkcRlkeenvlvhClaGvsRsvtlvv

AYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAH
|| |  |.     ||.    .| .   |.|| .|| .. .
aYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyek
0037934 (Phosphotyrosine protein) phosphatases II 79-219 3.2e-21 71.5 In-house 41-240 (243) alignment 
Range on Protein: 79-219
Range on HMM: 41-240/243.0
DILPQLCLGDA--------SHALDVEQLRRAGVSGVVNCAESA----------------------------------------TLSS-RSDYPAEWEYLG
...|.| ....         .| ... | . |.. .|.. |                                          .  .    .   . |. 
yvtprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhy

FDAQDH---SHYDMLGNHFEQVAAFIDA-----AAAAKRKVLIHCQAGVNRSAMIVVAYYMLST-HTPLLAALDHCARQRPC-ILRNVGFIEQLVVFAHE
.   ||   .. . | .....| .||..     |.  ...||.|| |||.|......||.||.  . .|. |...  .|||. .  . .....|  ...|
lpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyealle
subfamily_STYX_pd Subfamily STYX 79-217 5.6e-19 61.8 In-house 14-154 (166) alignment 
Range on Protein: 79-217
Range on HMM: 14-154/166.0
DILPQLCLGDASHAL--DVEQLRRAGVSGVVNCAES--ATLsSRSDYPAEWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSA
.||| | ||  | |.   .|.|.. |.. .|   ..  |.|  . ..| .. || .|  | .  ...  .. .| .||| .     |||.| .||. |||
eilpglflgpysaamksklevlkkhgithivcirqnieanl.ikpnfpdrfrylvldvadntvenii.rylptvkefiddslqkggkvlvhgnagisrsa

MIVVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFA
 .|.|| | .       |  .  ..| ||  | ||..|| .. 
alviayimetyglkyreafayvqerrfcinpnegfvsqlkeye
0042113 (Phosphotyrosine protein) phosphatases II 79-218 3.6e-17 58.1 In-house 49-240 (245) alignment 
Range on Protein: 79-218
Range on HMM: 49-240/245.0
DILPQLCLGDASHALDVE----QLRRAGVSGVVNCAESAT--------------------------------------------LSSRSDYPAEWEYLGF
.| |.. .... .. .||    .|.. |.. .|.. |                                                .. |     . ||..
ritpkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpw

DaqDHSHYdMLGNHFEQVAAFIDAAAA--AKRKVLIHCQAGVNRSAMIVVAYYM-----LSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAH
.  ||.    | ......  |.. | |  .. .||.|| |||.|......||.|          .|  |...  .|||..  . .....|  ...
p..dhgvp.dllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall
0046846 (Phosphotyrosine protein) phosphatases II 80-219 3.2e-26 87.6 In-house 15-171 (176) alignment 
Range on Protein: 80-219
Range on HMM: 15-171/176.0
ILPQLCLGDAS----------HALDVEQLRRAGVSGVVNCAESATLSS-------RSDYPAEWEYLGFDAQDHSHYDMlgNHFEQVAAFIDAAAAAKRKV
|...| ||..           .| ..|.|...|.. |||. |   |..          . ....|| ..  ||.  |.  ...... .||. |  ....|
inanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl..elllellefirealkeggpv

LIHCQAGVNRSAMIVVAYYMLS-THTPLLAALDHCARQRP-CILRNVGFIEQLVVFAHE
|.||.||..|....|.|| . .  . ... ||..  .||| ... . .....|  |...
lVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 80-218 2e-22 73.3 In-house 10-145 (148) alignment 
Range on Protein: 80-218
Range on HMM: 10-145/148.0
ILP-QLCLGDASHALDVEQLRRAGVSGVVNCAESATLSS--RsdypaEWEYLGFDAQDHSHYDmLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMI
| .  | ||.  .|.|.|.|.  ||. .||....       |       |||    .|. ..| |   ||...||.. | .. |.||.|.| || ||. .
ikdafLFlGskksaadlealkalgvtrivnatkerdnaldqr.....gieYlhvaldDkpked.lsaiFediiafvrkakdeGrrvLvhlqmGvsrssal

VVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAH
......   .  |  ||.    .|. .  | ||..||  . .
allwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleq
subfamily_MKPLT_pd Subfamily MKPLT 80-216 1.2e-16 54.6 In-house 24-156 (164) alignment 
Range on Protein: 80-216
Range on HMM: 24-156/164.0
ILP-QLCLGDASHALDVEQLRRAGVSGVVNCAESatlsSRSDYPAEWEYLGFDAQDHSHyDMLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVV
.|. .| ||.|.|| . . |.   .  .|| ..      .. .|   |||  . .| |. . |....|..| |.  |  .  .||.||. |. ||. . |
vledtlylGnakhatnekvlkdlkithivnvsqe....kkdafpksveYlqvkvedesd.eqlssfleraakfladaidsGGrvlvhcvqGksrsssvtv

AYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVF
|. ..|    |  | ..   .| ..  | ||. ||  |
afLikskgwtlkeayeylkerrsivapnrGflkqlakf
subfamily_MKPLV_pd Subfamily MKPLV 80-216 1.2e-16 54.6 In-house 24-156 (164) alignment 
Range on Protein: 80-216
Range on HMM: 24-156/164.0
ILP-QLCLGDASHALDVEQLRRAGVSGVVNCAESatlsSRSDYPAEWEYLGFDAQDHSHyDMLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVV
.|. .| ||.|.|| . . |.   .  .|| ..      .. .|   |||  . .| |. . |....|..| |.  |  .  .||.||. |. ||. . |
vledtlylGnakhatnekvlkdlkithivnvsqe....kkdafpksveYlqvkvedesd.eqlssfleraakfladaidsGGrvlvhcvqGksrsssvtv

AYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVF
|. ..|    |  | ..   .| ..  | ||. ||  |
afLikskgwtlkeayeylkerrsivapnrGflkqlakf
0040439 (Phosphotyrosine protein) phosphatases II 82-219 1e-18 63.3 In-house 34-244 (249) alignment 
Range on Protein: 82-219
Range on HMM: 34-244/249.0
PQLCLGDASHA------------------------LDVEQLRRAGVSGVVNCAESATLSSRS--------------------------------------
| | |.|  .|                         . ..|.. |.. .|.. .   |                                          
pglflsdyinAsyidgyyikrrfiatqgPlpetvedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltn

-DYPAEWEYLGFDAQDHShYDMLGNHFEQVAAFIDAAAA------AKRKVLIHCQAGVNRSAMIVVAYYM-----LSTHTPLLAALDHCARQRPCILRNV
  .. . ..|..   |    . .  .||.. .||.|.         . .||.|| |||.|......||.|        . .|. |...  .|||..  | 
lydgesrtvlhiqytdwp.dhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnp

GFIEQLVVFAHE
.....|  ...|
eqyrflyealle
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 84-215 2.5e-19 62.8 In-house 6-136 (145) alignment 
Range on Protein: 84-215
Range on HMM: 6-136/145.0
LCLGDASHALDVEQLRRAGVSGVVNCAESATLSSRSDYPAEWEYLGFDAQDHSHYDmLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVVAYYML
|  | | || ||  |.  |.| .|| | . ...|.. .  . | |   |.|   || | .||..|. |||        |..|| ||| ||  . ||. | 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesyd.lsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmk

STHTPLLAALDHCARQRPCILRNVGFIEQLVV
     |  |      .|     || |. .|. 
ycnmtlseaarqvrsnrllaypnvtflknlln
Init_tRNA_PT Initiator tRNA phosphoribosyl transferase 84-183 9.8e-07 19.1 Pfam-A 296-400 (451) alignment 
Range on Protein: 84-183
Range on HMM: 296-400/451.0
LCLGDASHALDV----EQLRRAGVSGVVNCAESATLSSRSDYPAEWEYLGFDAQDHSHyDMLGNHFEQVAAFIDAAAAA--KRKVLIHCQAGVNRSAMIV
| ||. .. | .    .. .   |. |... |. . |. ..  ..   |.. ..  .    | ....... ||..  .   ..|.|..|. | . |. .|
lvlgkieknlaaekslvakeekevdlvislsekivsseteekkkkvlelklesskkgs.keLrkalpkieefiksklsseknkkilvlcesGkdlsvgvv

VAYYML
.| . |
lailcl
DSPc Dual specificity phosphatase, catalytic domain 86-216 2.5e-27 90.4 Pfam-A 3-130 (133) alignment 
Range on Protein: 86-216
Range on HMM: 3-130/133.0
LGDASHALdVEQLRRAGVSGVVNCAESATLSsRSDYPAEWEYLGFDAQDhSHYDMLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVVAYYMLST
|| .|.|   ..|   |.. |.|.... . . ... . | |||.   .| .. . . ...|.. .||..|.. ..|||.|||||..|||....||.| . 
lgskstas.lalleklgitlvinvtkevpnn.naikkseieylripved.etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

HTPLLAALDHCARQRPCILRNVGFIEQLVVF
. .|  |...  ..|..| .|.||. ||. .
nlslneAyefvkerrskispnagflrqLley
DSPc Dual specificity phosphatase, catalytic domain 86-216 2.5e-27 90.4 In-house 3-130 (133) alignment 
Range on Protein: 86-216
Range on HMM: 3-130/133.0
LGDASHALdVEQLRRAGVSGVVNCAESATLSsRSDYPAEWEYLGFDAQDhSHYDMLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVVAYYMLST
|| .|.|   ..|   |.. |.|.... . . ... . | |||.   .| .. . . ...|.. .||..|.. ..|||.|||||..|||....||.| . 
lgskstas.lalleklgitlvinvtkevpnn.naikkseieylripved.etetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

HTPLLAALDHCARQRPCILRNVGFIEQLVVF
. .|  |...  ..|..| .|.||. ||. .
nlslneAyefvkerrskispnagflrqLley
0049772 (Phosphotyrosine protein) phosphatases II 88-221 9.6e-23 76.8 In-house 156-274 (314) alignment 
Range on Protein: 88-221
Range on HMM: 156-274/314.0
DASHALDVEQLRragvsgvvncaesATLSSRSDYPAE-WEYLGFDAQDhSHYDmLGNHFEQVAAFIDAAaAAKRKVLIHCQAGVNRSA-MIVVAYYMLST
.  .| |.|.|.               | ...... .  .|| ..  |  . . | ..|... .||..|  ....||.||.||..|.. ..|.|| |.  
neptaadlellk.............eelydpelferlgikylripvpD.gsap.lledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkll

HTPLLAALDHCARQRPcILRNVGFIEQLVVFAHEHN
. .|  ||..  ..|| |  | ||||||  .  ...
gvsleealedvrlkRp.inpnpgfieqleqyefile
0051429 (Phosphotyrosine protein) phosphatases II 91-217 5.7e-16 54.5 In-house 34-221 (272) alignment 
Range on Protein: 91-217
Range on HMM: 34-221/272.0
HALDVEQLRRAGVSGVVNCAESATLSSR--SDYPAEWEYLGFDAQDHSHYDMLGNH--------------------------------------------
 | |...|.. |.. .|.  .   . .   . |..  .|| ..  |.|....| ..                                            
taadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdh

---FEQVAAFIDAAAAaKRKVLIHCQAGVNRSAMIVVAYYMLsTHTP--------------LLAALDHCARQRPCILRNVGFIEQLVVFA
    |.. ..... .. ...||.|| ||..|....|.....|    .              |..|...  .|||..  . .....|  ..
gvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeal
subfamily_PTPMT1_pd Subfamily PTPMT1 95-213 3.8e-15 50.7 In-house 38-161 (171) alignment 
Range on Protein: 95-213
Range on HMM: 38-161/171.0
VEQL-RRAGVSGVVNCAESATLSSRSDYPAEWEYLGFDAQDHSHYDML----GNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVVAYYMLSTHTPL
...| .   | .||.. |   |   ..   ||. || .    .  |.      .. |.   ||.  |  ...| .||.||  ||| .| .| |....  .
ikeLiekenvkavvslneeyelkalansteewkklgveqlqlatvDfteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklsp

LAALDHCARQRPCILRNVGFIEQL
  ||.. ...|. |. .    ..|
eeAlkalkkkRkiirlakkqwkal
0045450 (Phosphotyrosine protein) phosphatases II 96-219 7.3e-19 64.1 In-house 125-302 (307) alignment 
Range on Protein: 96-219
Range on HMM: 125-302/307.0
EQLRRAGVSGVVNCAESATLSSR---S----------------------DyPAEWEYLGFDAQDH-----------------SHYDMLGnHFEQVAAFID
..|.. ||. .|.. |.  | ..                             ... .. .  .|.                  ...    .||.. .||.
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseeh.ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvpp.sfeelldfie

AAAA------AKRKVLIHCQAGVNRSAMIVVAYYMLSTH--------TPLLAALDHCARQRPCILRNVGFIEQLVVFAHE
.. .       . .||.|| |||.|......||.||. .         .|| |...  .|||..  | .....|  ...|
evrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle
0038934 (Phosphotyrosine protein) phosphatases II 98-219 1.6e-18 62.5 In-house 52-175 (194) alignment 
Range on Protein: 98-219
Range on HMM: 52-175/194.0
LRRAGVSGVVNCAESATLSSRSDYPA-EWEYLGFDAQDHSH---YDMLGNHFEQVAAFIdaAAAAKRKVLIHCQAGVNRSAMIVVAYYMLSTHTPLLAAL
|.  ..  |..  .. .. .......   ||| .   |. .   ...| . .. |  |.  .. .. .|..|| ||..|....|.|| . . . .. .|.
llnvklglvidltnteryYdpeefekagieylklpfpddgtvPsleillrfldlvdefl..nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAi

DHCARQRPCILRNVGFIEQLVVFAHE
.. .. || ...|....|.|... .|
alfrekRpgaipnqdyleallkryke
0043336 (Phosphotyrosine protein) phosphatases II 123-219 3.8e-15 51.6 In-house 176-275 (278) alignment 
Range on Protein: 123-219
Range on HMM: 176-275/278.0
AEWEYLGFDaqDHSHYDMLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVVAYYM-----LSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFA
  . |||.   ||.  . |  ... . |...| .  . .||.|| |||.|.......|..        . .|. |...  .|||... .  ....|  ..
thyhylgwp..dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal

HE
.|
le
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 124-219 3.2e-18 59.5 In-house 55-151 (154) alignment 
Range on Protein: 124-219
Range on HMM: 55-151/154.0
EWEYLGFDAQDHSHYDMLgNHFEQVAAFIDAAA--AAKRKVLIHCQAGVNRSAMIVVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAHE
  |||  .  |. ..|.. ......  ||| |     . |||.|...|| ||| ....|.| . . .|  ||      |. |  | ||..|| .|  |
iieylnlelfddvnfdii.ekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifeke
subfamily_PTEN_pd Subfamily PTEN 129-195 7e-07 24.4 In-house 86-151 (184) alignment 
Range on Protein: 129-195
Range on HMM: 86-151/184.0
GFDAQDHSHYDMLGNHFEQVAAFIDAAAaaKRKVLIHCQAGVNRSAMIVVAYYMLSTHTPLL-AALDH
.|| .   . ..| .  |.. .....    |. | .||.||  |. ...||| . |....    ||..
pfdDhnppplelleeivediekwleedk..knvvvvHCkaGkGRtGvlivayllkslllekaeealel
0051299 (Phosphotyrosine protein) phosphatases II 130-208 4.4e-10 35.0 In-house 190-273 (288) alignment 
Range on Protein: 130-208
Range on HMM: 190-273/288.0
FDAQDHSHYDMLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVVAYYM-----LSTHTPLLAALDHCARQRPCILRNVG
..  ||.  | .   .. . ....| |. .  |..|| |||.|..........        .  .| |. .  .|||..  .. 
tnwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe
subfamily_MSG5_pd Subfamily MSG5 134-215 2.1e-12 40.5 In-house 74-155 (165) alignment 
Range on Protein: 134-215
Range on HMM: 74-155/165.0
DHSHYDMLGNHFEQVAAFIDAAAAAKRKVLIHCQAGVNRSAMIVVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVV
.  |   .   . ...  | || . ..|.|.||| |. ||| ..||| |      |  | |.   .   |  ..|.| ||. 
ewehdskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlme
0048567 (Phosphotyrosine protein) phosphatases II 137-203 1.5e-06 22.6 In-house 52-121 (157) alignment 
Range on Protein: 137-203
Range on HMM: 52-121/157.0
HYDMLGNHFEQVAAFIDAAAAAKRKVLIHCQAGV---NRSAMIVVAYYMLSTHTPLLAALDHCARQRPCI
....| . . ..  |..    |.... .|| ||     |.|... .|..|  . .   |... .  || .
nlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgs
0039614 (Phosphotyrosine protein) phosphatases II 142-220 1.6e-15 52.8 In-house 202-288 (297) alignment 
Range on Protein: 142-220
Range on HMM: 202-288/297.0
GNHFEQVAAFIDAAAA---AKRKVLIHCQAGVNRSAMIVVAYYM-----LSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAHEH
 ... ..  ... | |    ...||.|| |||.|......||.|        .  .| |...  .|||..  . .....|  ...|.
lellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallel
0040438 (Phosphotyrosine protein) phosphatases II 143-220 7.1e-16 53.8 In-house 189-275 (317) alignment 
Range on Protein: 143-220
Range on HMM: 189-275/317.0
NHFEQVAAFIDAAAAA----KRKVLIHCQAGVNRSAMIVVAYYM-----LSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAHEH
 ..... .|..|. .|    . .||.|| |||.|......||.|        .  .  |...  .|||..  . .....|  ...|.
pspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalley
0036941 (Phosphotyrosine protein) phosphatases II 143-219 2.3e-14 48.8 In-house 185-275 (297) alignment 
Range on Protein: 143-219
Range on HMM: 185-275/297.0
NHFEQVAAFIDAAAA------AKRKVLIHCQAGVNRSAMIVVAYYM--------LSTHTPLLAALDHCARQRPCILRNVGFIEQLVVFAHE
...... .||...         . .||.|| |||.||.....|..|             ..| |. .  .|||..  .... ..|  .  |
espaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle
0050432 (Phosphotyrosine protein) phosphatases II 144-207 1.8e-08 29.5 In-house 215-285 (308) alignment 
Range on Protein: 144-207
Range on HMM: 215-285/308.0
HFEQVAAFIDAAAAA--KRKVLIHCQAGVNRSAMIVVAYYM-----LSTHTPLLAALDHCARQRPCILRNV
..|.. .|....     . ....|| |||.|.. .......        .  .. |. .  .|||.   ..
speilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp
0047943 (Phosphotyrosine protein) phosphatases II 145-215 1.2e-10 36.8 In-house 185-266 (273) alignment 
Range on Protein: 145-215
Range on HMM: 185-266/273.0
FEQVAAFIDAAAA------AKRKVLIHCQAGVNRSAMIVVAYYM-----LSTHTPLLAALDHCARQRPCILRNVGFIEQLVV
.|..  ||...         . .|..|| |||.|..........           .| |. .  .|||..  .. ....|  
lesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrflye
0046845 (Phosphotyrosine protein) phosphatases II 145-211 1.1e-09 33.5 In-house 184-264 (284) alignment 
Range on Protein: 145-211
Range on HMM: 184-264/284.0
FEQVAAFIDAAAAA------KRKVLIHCQAGVNRSAMIVVAYYMLST--------HTPLLAALDHCARQRPCILRNVGFIE
.|.. .|....  .      . ....|| |||.|..........|.         . ..| |. .  .|||.   ..  ..
pedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtleqyr
PTPc_DSPc_SM00012 146-185 1e-07 27.4 In-house 27-65 (105) alignment 
Range on Protein: 146-185
Range on HMM: 27-65/105.0
EQVAAFIDAAAAaKRKVLIHCQAGVNRSAMIVVAYYMLST
..|  .  ...  .  |..||.|||.|....|.....|. 
ravkknknkses.skpvvVhCsaGvgRtgtfvaldillqq
Y_phosphatase Protein-tyrosine phosphatase 148-189 5.6e-06 21.3 Pfam-A 166-205 (235) alignment 
Range on Protein: 148-189
Range on HMM: 166-205/235.0
VaafidaaAAAKRKVLIHCQAGVNRSAMIVVAYYMLSTHTP-----L
        .| . .|..|| |||.|....|.. ..|.  .      .
k.......eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdv
Y_phosphatase Protein-tyrosine phosphatase 148-189 5.6e-06 21.3 In-house 166-205 (235) alignment 
Range on Protein: 148-189
Range on HMM: 166-205/235.0
VaafidaaAAAKRKVLIHCQAGVNRSAMIVVAYYMLSTHTP-----L
        .| . .|..|| |||.|....|.. ..|.  .      .
k.......eaksgpvvVhCsaGvgRtgtfvaldilleqleaeeevdv
subfamily_RNGTT_pd Subfamily RNGTT 150-213 4.3e-07 23.8 In-house 106-167 (189) alignment 
Range on Protein: 150-213
Range on HMM: 106-167/189.0
AFIDaaAAAKRKVLIHCQAGVNRSAMIVVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQL
 |..    ... . .||. | ||.  ..|.| .  ..  . ||..  |. ||  . .  ....|
effk..knpeevigvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiykedylkel
subfamily_PTPDC1_pd Subfamily PTPDC1 154-216 1.8e-06 22.5 In-house 109-171 (182) alignment 
Range on Protein: 154-216
Range on HMM: 109-171/182.0
AAAAAKRKVLIHCQAGVNRSAMIVVAYYMLSTHTPLLAALDHCARQRPCILRNVGFIEQLVVF
| |  . || .|| ||  |  ... .| . ...     |..    .||  ..  . .| .. |
afalqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvkef