Gene MbreMKP-Un-6 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP_MKP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP007_AA protein Get Run
MbreP007_AA_216-358 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 103-201 1.7e-08 27.0 Pfam-A 12-112 (113) alignment 
Range on Protein: 103-201
Range on HMM: 12-112/113.0
SQLLVIDVRSNAAYDSEHVRSSISVDW------EALECADMLDCEaTVHQRFWHRRFFNVVLYDdestpeaEATTLASFSAALQT---------Ekrcsr
......|||| ..|. .|.. ...|..      ..|   | |  |    .  .. .   ||.|.       . .. ... |||           .     
ekvvllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaee.leesgkkldkdktvvvyc.......rsgnrsggaaalllalilkelgyk.....

TVHKLRGGLRQFME
.|. |.||. .. .
nvyvLdGGfeawka
0049772 (Phosphotyrosine protein) phosphatases II 176-356 4.5e-31 104.1 In-house 84-271 (314) alignment 
Range on Protein: 176-356
Range on HMM: 84-271/314.0
SAALQTEKRCSRTVHKLRG-----------------------G---------------------LRQFMEAYpflvkghpaftdaefpseikdgflflgS
 . ..|..  . ||. .|                        .                     |..... .                           .
lkfIatqgpleitvvdfreepvlyyngwrmvlrgdlnvrdivmsrdevladelsrLdaAlgKtpllildgng...........................n

WKSASNLEALKalnitrivnaTASCDMPFDQQ--AVYLHCPLDDkPDHDLSQFFGDFIAFVRKAqGEGQRVLVHCQMGMSRSS-ALAILWMMDFHDMTLK
. .|..|| ||          .  .| .. ..    ||..|..| .. .|...| .|..|...|  .| .|||||..|..|.  .... ..|  ....|.
eptaadlellk..........eelydpelferlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsle

QAYDYVHSKRPyINPNPGFLKQLGEWEH
.|...|..||| |||||||..|| ..| 
ealedvrlkRp.inpnpgfieqleqyef
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 211-359 8.9e-80 259.4 In-house 5-148 (148) alignment 
Range on Protein: 211-359
Range on HMM: 5-148/148.0
PaftdaeFPSEIKDGFLFLGSWKSASNLEALKALNITRIVNATASCDMPFDQQAV-YLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMS
       |||||||.||||||.|||..|||||||..|||||||...|...||... |||..|||||..|||..|.|.|||||||..||.|||||.|||.|
t......fpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvs

RSSALAILWMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEHANR
||||||.||..||....||.|...|.|||.|..||.||||||.|.|.|.|
rssalallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleqaer
subfamily_DSP6_pd Subfamily DSP6 215-357 4.1e-35 114.6 In-house 10-153 (158) alignment 
Range on Protein: 215-357
Range on HMM: 10-153/158.0
DAEFPSEIKDgFLFLGSWKSASNLEALKALNITRIVNATASCDMPFDQQA--VYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSS
.|||| || . .|.||| |.|||||.|| |.| ...| |   .  |...    ||. |..|.  ..|..|| . |.|. .|. . . |||||  |.||| 
eaefpveilp.llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsv

ALAILWMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEHA
.... ..|  . ..|..|||.|..... | ||  |..|| ..|. 
tvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfers
subfamily_Slingshot_pd Subfamily Slingshot 215-355 1.9e-34 112.5 In-house 15-154 (169) alignment 
Range on Protein: 215-355
Range on HMM: 15-154/169.0
DAEFPSEIKDgFLFLGSWKSASNLEALKALNITRIVNATASCDMPFDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSAL
  . .|.| | ...|||   ||||| ||  ... |.| |  .|  |...  ||.  . |....|| ... .   |..||. .| .|||||.||.|||.. 
qldsaskifd.hvylGsewnasnleelkengveyilnvtkeidnffpekfeylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsast

AILWMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWE
 | . |  ....|..|..||...|  |.||.|||||| |.|
viayamkeyglsleealeyvkerrsvikPnkgflkqleeye
subfamily_LRR-DSP_pd Subfamily LRR-DSP 216-356 1.6e-32 106.7 In-house 117-256 (263) alignment 
Range on Protein: 216-356
Range on HMM: 117-256/263.0
AEFPSEIKDGfLFLGSWKSASNLEALKALNITRIVNATASCDMPFDQQAVYLHC-PLDDKPDHDLSQFFGDFIAFVRKAQGEGQrVLVHCQMGMSRSSAL
.  |.|| |. ||||. .|| |   || |..| |. | | ..  | .   ||    ..| .. |.||.| .  ||. . . .|  |||||. |.||||.|
ssvPdeiidk.lflGgldsannksilkdlgvthillavadfePlfPklfkylsiddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsstl

AILWMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEH
 | ..|  . ...|.|.| | .||| |.|||||..||  .|.
visylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek
subfamily_STYXL1_pd Subfamily STYXL1 217-358 7.1e-28 90.8 In-house 9-153 (157) alignment 
Range on Protein: 217-358
Range on HMM: 9-153/157.0
EFPSEIKDGFLFLGSWKSASNLEALKALNITRIVNATASCDMPFDQQ---AVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSA
..|.|.  |.|.|| .| | | .  | | .   || .  .|  .. .   |  ||....|... || ... . . |. | . ||. |||  . |.||| |
tyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaa

LAILWMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEHAN
..| ..|  ...|||.||.|..  .. ..|| .|..|| |||.  
viiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql
0044763 (Phosphotyrosine protein) phosphatases II 218-357 2e-38 127.1 In-house 22-169 (178) alignment 
Range on Protein: 218-357
Range on HMM: 22-169/178.0
FPSEIKDGfLFLGSWKSASNLEALKALNITRIVNATASCDMPFDQQ---------AVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQ-GEGQRVLVHCQMG
 .||| .| |.|||. .|..|| ||.|.|| ||| |  . ..| .            |||.|..| .. ||...| .|..|...|.  .| .|||||..|
naseilpg.lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaG

MSRSSALAILWMMDFHDMTLKQAYDYVHSKRPyINPNPGFLKQLGEWEHA
..|| .|.....|  ....| .|...|...|| |.||||.|.|| |.|  
vgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelr
0048076 (Phosphotyrosine protein) phosphatases II 218-356 1.5e-36 120.6 In-house 3-140 (145) alignment 
Range on Protein: 218-356
Range on HMM: 3-140/145.0
FPSEIKDGfLFLGSWKSASNLEALKALNITRIVNATASCDMPFDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALAIL
.|||| .| |.|||. .|..|| || |.||...| |  .. ....   ||..|..| .  ||.... .|..|...|. || .|||||..|..|. .|...
wpseilpg.lylgslptaldlellkdlgittvlnltselellerlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlvaa

WMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEH
..|  ....| .|...|.|.||...||||.|..| |.|.
ylmlllgvsleealelvrsqrpgavpnpgqlrflyefel
0048179 (Phosphotyrosine protein) phosphatases II 218-355 2.3e-36 120.0 In-house 3-141 (144) alignment 
Range on Protein: 218-355
Range on HMM: 3-141/144.0
FPSEIKDGfLFLGSWKSASNLEALKALNITRIVNATASCDMPFDQQA--VYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALA
.|||| .| |.|||. .|..|| ||.|.|| ..| | .....|  .    |||.|..| .  ||.... .|..|...|. || .|||||..|..|. .|.
npseilpg.lylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

ILWMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWE
....|  ....|..|...|.|.||...||||.|..| |.|
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleye
subfamily_MKPLT_pd Subfamily MKPLT 218-356 3.4e-33 108.5 In-house 20-158 (164) alignment 
Range on Protein: 218-356
Range on HMM: 20-158/164.0
FPSEIKDGFLFLGSWKSASNLEALKALNITRIVNATASCDMPFDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALAIL
.|| . .  |.||  | | | . ||.|.|| ||| .  .   | .  .||   ..|..|. ||.|.     |. .|   | ||||||..| ||||. .. 
ypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtva

WMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEH
... ..  |||.||.|.  .|  ..|| |||||| ..|.
fLikskgwtlkeayeylkerrsivapnrGflkqlakfee
subfamily_MKPLV_pd Subfamily MKPLV 218-356 3.4e-33 108.5 In-house 20-158 (164) alignment 
Range on Protein: 218-356
Range on HMM: 20-158/164.0
FPSEIKDGFLFLGSWKSASNLEALKALNITRIVNATASCDMPFDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALAIL
.|| . .  |.||  | | | . ||.|.|| ||| .  .   | .  .||   ..|..|. ||.|.     |. .|   | ||||||..| ||||. .. 
ypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafpksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtva

WMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEH
... ..  |||.||.|.  .|  ..|| |||||| ..|.
fLikskgwtlkeayeylkerrsivapnrGflkqlakfee
0041856 (Phosphotyrosine protein) phosphatases II 218-358 8.4e-30 99.1 In-house 18-172 (182) alignment 
Range on Protein: 218-358
Range on HMM: 18-172/182.0
FPSEIKDGfLFLGSWKS--------------ASNLEALKALNITRIVNATasCDMPFDQQA-----VYLHCPLDDKPDHDlsqfFGDFIAFVRKAQGEGQ
....| .. |.|||...              |..|. || |.|| |||.|  ... . .        ||. | .| .  |    . ....|..... || 
dldyInan.lylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywpellerlgiqylylpwpDhgvpd....ldelldfieevleegg

RVLVHCQMGMSRSSALAILWMMDFHDMTLKQAYDYVHSKRP--YINPNPGFLKQLGEWEHAN
.||||| .|..|. .|.....|  ....| .|...| |.||   |.|| .|. || ..|.  
pvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallelll
subfamily_DSP1_pd Subfamily DSP1 219-357 2.1e-44 145.5 In-house 17-155 (163) alignment 
Range on Protein: 219-357
Range on HMM: 17-155/163.0
PSE-IKDgFLFLGSWKSASNLEALKALNITRIVNATASCDMPFDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALAIL
|.| |.| ||.||| ..||||| ||.|.|| |.|.....|  |..   | . .|.|.|. |.|. | . | |. ... .. .||.|||.|.||||.| ..
Pvekild.fLylGsetvasnleiLkslgitailnvskeldnvfedlfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstlcla

WMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEHA
..|  . ..|..|.|.|...|. |.|| || .|| ..|. 
ylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekk
PTPc_motif_SM00404 219-356 2.2e-37 123.1 In-house 2-139 (140) alignment 
Range on Protein: 219-356
Range on HMM: 2-139/140.0
PSEIKDGfLFLGSWKSASNLEALKALNITRIVNATASCDMP-FDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALAIL
||.| .. |.|||...|.|.. ||.|.|| ..|.| .....  ...  .|..||||.   .||...   ..|...|. .|..||||||.|.||| .|.| 
psrilph.lylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

WMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEH
..|. . ..|..||..|...|| |.|| .|..|| |.| 
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyek
0051429 (Phosphotyrosine protein) phosphatases II 219-355 3.5e-20 68.2 In-house 16-221 (272) alignment 
Range on Protein: 219-355
Range on HMM: 16-221/272.0
PSEIKDGFLFLGSWK---SASNLEALKALNITRIVNATASCDMPFDQ------QAVYLHCPLDDKPDHDLS-----------------------------
 ...|.|.|....     .| ....|| |.|. ||. .  . .....      .. |||.|. |  . . .                             
grvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltllls

----------------------QFFGDFIAFVRKaqgeGQRVLVHCQMGMSRSSALAILWMMDfHDMT--------------LKQAYDYVHSKRPYINPN
                      . . ........    |..|||||  |..|.  .. |...  ....              | .|.... ..||.....
agearevmhlhytdwpdhgvpqeallellellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqt

PGFLKQLGEWE
......| |..
eeqylflyeal
subfamily_DSP12_pd Subfamily DSP12 221-357 1.7e-29 97.2 In-house 4-142 (155) alignment 
Range on Protein: 221-357
Range on HMM: 4-142/155.0
EIKDGfLFLGSWKSASNLEALKALNITRIVNATASC--DMPFDQQAVY-LHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALAIL
.|..| |.||. . . . | || |.||...  .     ..  ... |. .. ...|.|. |. ... . ..|. .|  |.. ||||||.|.|||... | 
rilpg.lylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviA

WMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEHA
..|  ... |..|.. |..|.| |.|| |||.||  .|. 
YlmkkeklslekAlklvkekkpeiepNegFleQLklfekm
PTEN_1 221-353 3.4e-25 84.0 In-house 38-186 (196) alignment 
Range on Protein: 221-353
Range on HMM: 38-186/196.0
E----IKDGFLFLGSWKSA-SNLEALKALNITRIVNATASCDMP---------FDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQG--EGQRVLVHC
.      |..|..||.|.. ..|. ||. .|| .|| .  ....         |...  |||.| .| .  .||..|     |   ..   .|  |||||
rpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHC

QMGMSRSSALAILWMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGE
. |..||  ... ..|  . .| ..| ..| .||| ..||......| |
kaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlle
0045098 (Phosphotyrosine protein) phosphatases II 223-356 1.3e-26 89.0 In-house 25-269 (278) alignment 
Range on Protein: 223-356
Range on HMM: 25-269/278.0
KDGFLFLGSWK-----------------------------------------SASNLEALKALNITRIVNAT----------------------------
   .|.||...                                          |.... |. |.|| ||..|                            
itpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltygdftvt

------------------------ASCDMPFDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQG--------------EGQRVLVHCQMGMSRSSALA
                        ...   . ..  ||. |  . |.......| ... |.|.|.               .| .|||||..| .|. .|.
llseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlv

ILWMMDFH---DMTLKQAYDYVHSKRPY-INPNPGFLKQLGEWEH
....|  .    ..| .|.... |.||. . .|......| |.. 
aaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefll
0051082 (Phosphotyrosine protein) phosphatases II 223-351 1.8e-24 81.5 In-house 12-146 (151) alignment 
Range on Protein: 223-351
Range on HMM: 12-146/151.0
KDGfLFLGSWKSASNLEALKALNITRIVNATASCDMPFDQQA------VYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGE-GQRVLVHCQMGMSRSSALA
 .| |..... .| .|| || |.|. ||| .    .... .        .||.|..| ||..|...|  ...|.....   .. ||||| .|..|. .|.
tgg.lyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGtlv

ILWMMDfHDMTLKQAYDYVHSKRP-YINPNPGFLKQL
.|..|  ....| .|......||| ...|| .||.||
alylml.lgvsleealeeyrlkrpgvvqpnqqflfql
subfamily_DSP8_pd Subfamily DSP8 225-356 5.5e-30 98.0 In-house 20-152 (159) alignment 
Range on Protein: 225-356
Range on HMM: 20-152/159.0
GFLFLGSWKSASNLEALKALNITRIVNATASC-DMPFDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALAILWMMDFH
 .|.||| | . . |.|..|.|. ..||  || .. . ... .|..|. || | .|...|   . |. ||. | .|||||.  |.|||...|| ..|   
knlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiayimktl

DMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEH
.|.| .|| .|..||| |.||  ||.|| |.|.
emsldeayrfvkekrptispnlnflgqLleyek
0049260 (Phosphotyrosine protein) phosphatases II 225-355 9.5e-30 98.7 In-house 13-146 (152) alignment 
Range on Protein: 225-355
Range on HMM: 13-146/152.0
GFLFLGSWKSASNLEALKALNITRIVNATASCDMPFD---QQAVYLHCPLDDKPDHDLSQFFGDFIAFVRK-AQGEGQRVLVHCQMGMSRSSALAILWMM
.....|..  |.... || |.|| ||. |  ......   |   |||.| .| .  ||||.. ... |..| |. .| .|||||  |..|. .|.....|
atqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylm

DfHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWE
  ....|..|...| .|||...||||.|..| |.|
l.lgvsleeavalvrekRpgavpnpgqlrflyefe
0046846 (Phosphotyrosine protein) phosphatases II 225-357 5e-28 93.4 In-house 17-171 (176) alignment 
Range on Protein: 225-357
Range on HMM: 17-171/176.0
GFLFLGSWK----------SASNLEALKALNITRIVNATASC-----------DMPFDQQAVYLHCPLDDKPDHDLsQFFGDFIAFVRKAQGEGQRVLVH
. |.|||.            |..|| || |.|| .|| |              .   . .  |||.| .|    || . . ....|.|.|. ||..||||
anlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggpvlVH

CQMGMSRSSALAILWMMDF-HDMTLKQAYDYVHSKRP-YINPNPGFLKQLGEWEHA
|..|..|. .|......   ..... .|...| ..|| .. ..|.....| |.|. 
CsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell
0036282 (Phosphotyrosine protein) phosphatases II 225-356 9.4e-26 86.0 In-house 17-167 (174) alignment 
Range on Protein: 225-356
Range on HMM: 17-167/174.0
GFLFLGSWKSAsNLEALKALNITRIVNATASCDMP---------------FDQQAVYLHCPLDDKPDHDLSQfFGDFIAFVRKAQGE--GQRVLVHCQMG
. |..|..  | ..| || |.|| .|. . .. .                 .    ||..| .|    |||. . .|. ||..|. |  |  ||||| .|
prliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVHCsaG

MSRSSALAILWMMDFHDM-TLKQAYDYVHSKR---PYINPNPGFLKQLGEWEH
 .|. .|.....|  . . .| .|.|.|...|   |.. ..|.....| ..| 
vgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 225-357 2.4e-23 76.2 In-house 8-151 (154) alignment 
Range on Protein: 225-357
Range on HMM: 8-151/154.0
GFLFLGSWKSASNLEALKALNITRIVNATASCDMPFDQQ---------AVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQ--GEGQRVLVHCQMGMSRSSA
 ||...| ..| |   |.  ||. |.|     .  | ..           ||.  | |....|. . .     |...|    | ..||||.. |.|||.|
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaa

LAILWMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEHA
|.| ..||   ..| .|.  ... |. |.|| ||||||  .|  
llisylmdklkislslalellkdsryiikPnqGflkqleifeke
0042113 (Phosphotyrosine protein) phosphatases II 225-355 5.8e-22 73.7 In-house 52-239 (245) alignment 
Range on Protein: 225-355
Range on HMM: 52-239/245.0
GFLFLGSWKSASNLE----ALKALNITRIVNATASC----------------------------------------------DMPFDQQAVYLHCPLDDK
. ...... .....|     |. |.|| ||. |                                                 | .  .  .|.. | .| 
pkfiatqgPlpetvedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdh

PDHDLSQFFGDFIAFVRKAQG--EGQRVLVHCQMGMSRSSALAILWMM-----DFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWE
.  ||.. . ||. |||||.   .. .||||| .| .|. .......|       ....| .|.... |.|| . ..|.....| |..
gvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeal
subfamily_STYX_pd Subfamily STYX 225-357 1.8e-21 69.9 In-house 18-156 (166) alignment 
Range on Protein: 225-357
Range on HMM: 18-156/166.0
GfLFLGSWKSA--SNLEALKALNITRIVNATASC-----DMPFDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALAIL
| |||| . .|  | || ||   || ||    .         |...  ||   . |..  .. ...    .|. ..  .| .|||| . |.|||.|| | 
g.lflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaalvia

WMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEHA
..|. . .  ..|. ||  .|  |||| || .|| |.|  
yimetyglkyreafayvqerrfcinpnegfvsqlkeyeai
subfamily_DSP14_pd Subfamily DSP14 226-367 1.5e-37 122.9 In-house 13-153 (157) alignment 
Range on Protein: 226-367
Range on HMM: 13-153/157.0
FLFLGsWKSASNLEALKALNITRIVNATASCDMPFDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALAILWMMDFHDM
 |||.   .|.. |.||. .|| |.|.|     .  ..  ... |..|.|...|...|   .. ..... .| ..|||| .|.||| .|.. ..| .. .
sLfls.gvaalskellkkkkitliinvtvelpntklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyekl

TLKQAYDYVHSKRPYINPNPGFLKQLGEWEHANRGSSTIRFP
.|..|| .|.|.|| |.|| || ||| ..|.. .|.|...  
sLreayklvksaRpiirPNvGFwkqlidyEkklkgkssvkmv
subfamily_DSP10_pd Subfamily DSP10 226-357 8.5e-37 120.5 In-house 20-152 (159) alignment 
Range on Protein: 226-357
Range on HMM: 20-152/159.0
FLFLGSWKSASNLEALKALNITRIVNATASCDMPFDQ-QAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALAILWMMDFHD
|||||| | |..|.||. |||| ..| |.|. . |.. .  | . |. |.  ..|.| | . ..|. .|. .|.||||||| |.|||....| ..|   .
fLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhln

MTLKQAYDYVHSKRPYINPNPGFLKQLGEWEHA
..|..||..|..||| | || .|. || |.|. 
lslndaykfvkekrpiisPnLnfmGqLlefeke
subfamily_DSP19_pd Subfamily DSP19 226-357 6.8e-35 114.7 In-house 18-149 (152) alignment 
Range on Protein: 226-357
Range on HMM: 18-149/152.0
FLFLGSWKSASNLEALKALNITRIVNATASCDMPFDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALAILWMMDFHDM
 |.|||  .|.. |.||  .|| |.| ..  .  | ..  ||. .. |.|..||.... . . |...|. .  .|||||. |.|||....| ..|  ...
rlylgsqdvaadkeilkekkitHilnvatgvpnvfpkdftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeel

TLKQAYDYVHSKRPYINPNPGFLKQLGEWEHA
.|..|...|...|| |.|| ||.||| |.|. 
sleealelvrearpcikPneGFikqLkeyeae
0043147 (Phosphotyrosine protein) phosphatases II 226-356 9.6e-30 98.9 In-house 25-158 (172) alignment 
Range on Protein: 226-356
Range on HMM: 25-158/172.0
FLFLGSWKSASNLEALKALNITRIVNATAS---CDMPFDQQAVYLHCPLDDKPDHdLSQFFGDFIAFVRK--AQGEGQRVLVHCQMGMSRSSALAILWMM
.......  |.... || |.|| |||.|     ..  ...   ||..| .| .   |.... .|. |...  |. .| .||||| .|..|. .|.....|
tqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylm

DfHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEH
  ....| .|...| .|||.. .||.....| ..|.
l.lglsleeavalvrekRpgavqnpsqyrflyyfek
0037934 (Phosphotyrosine protein) phosphatases II 226-355 4e-22 74.4 In-house 45-238 (243) alignment 
Range on Protein: 226-355
Range on HMM: 45-238/243.0
FLFLGSW--------KSASNLEALKALNITRIVNATASC---------------------------------------------DMPFDQQAVYLHCPLD
 |.....        . ||... |. |.|| ||. |  .                                             | .. .   |.. |  
rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwp

D----KPDHDLSQFFGDFIAFVRK-----AQGEGQRVLVHCQMGMSRSSALAILWMMDFH-DMTLKQAYDYVHSKRPY-INPNPGFLKQLGEWE
|        || .|. . ..|...     |  .| .||||| .| .|. .|.....|  . ...| .|.... ..||. . ..|.....| |..
dhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal
DSPc Dual specificity phosphatase, catalytic domain 227-356 4.3e-36 118.7 Pfam-A 1-132 (133) alignment 
Range on Protein: 227-356
Range on HMM: 1-132/133.0
LFLGSWKSASnLEALKALNITRIVNATASCDMPF---DQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALAILWMMDFH
|.|||...|| |. |..|.|| ..|.| ... ..   ...  ||..|..|. . ..|... . ..|..||. .|..||||||.|.||| .|.| ..|. .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

DMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEH
 ..|..||..| ..|. |.|| |||.|| |.| 
nlslneAyefvkerrskispnagflrqLleyer
DSPc Dual specificity phosphatase, catalytic domain 227-356 4.3e-36 118.7 In-house 1-132 (133) alignment 
Range on Protein: 227-356
Range on HMM: 1-132/133.0
LFLGSWKSASnLEALKALNITRIVNATASCDMPF---DQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALAILWMMDFH
|.|||...|| |. |..|.|| ..|.| ... ..   ...  ||..|..|. . ..|... . ..|..||. .|..||||||.|.||| .|.| ..|. .
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

DMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEH
 ..|..||..| ..|. |.|| |||.|| |.| 
nlslneAyefvkerrskispnagflrqLleyer
subfamily_DSP15_pd Subfamily DSP15 227-357 6e-30 98.3 In-house 9-138 (151) alignment 
Range on Protein: 227-357
Range on HMM: 9-138/151.0
LFLGSWKSASNLEALKALNITRIVNATAScDMPFDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALAILWMMDFHDMT
|.||  . ... | ||  ||| |..   .   .. ..  |.  ...| |. .||.|| . . |. |.. ... ||||| .|.|||  |.....|   .. 
lylgnfrdskdeelLkeknithilsvhdn.akkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvteln

LKQAYDYVHSKRPYINPNPGFLKQLGEWEHA
 ..| . .. .|   ||| || .|| |.|..
wrdalevikaaRsvanPnfGfkrqlkeyekt
subfamily_DSP3_pd Subfamily DSP3 227-356 1.2e-28 93.7 In-house 18-155 (162) alignment 
Range on Protein: 227-356
Range on HMM: 18-155/162.0
LFLGSWKSASNLEALKALNITRIVNATAS------CDMPF--DQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGE-GQRVLVHCQMGMSRSSALAIL
|..|  ..|.. . ||.| || ..||...       .  |  | .  ||  ..||.|  |||..|    .|...|  .   .|||||..|.|||..|.. 
lyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvla

WMMDFHDMTLKQAYDYVHSKRPyINPNPGFLKQLGEWEH
..| ...|||..|   |..||  | || |||||| | ..
yLmirrkmtlveairtvrkkRe.ilPneGFlkqLaelde
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 227-353 1.4e-21 70.1 In-house 6-136 (145) alignment 
Range on Protein: 227-353
Range on HMM: 6-136/145.0
LFLGSWKSASNLEALKALNITRIVNATASCDMPF----DQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALAILWMMDF
|. ||   |... .|. | |.|||| .|.  .       ..   |    .|   .|||| | .   |. | . ||  |.|||  |.||| .... ..| .
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

HDMTLKQAYDYVHSKRPYINPNPGFLKQLGE
 .||| .|   |.|.|    ||  |||.| .
cnmtlseaarqvrsnrllaypnvtflknlln
0036941 (Phosphotyrosine protein) phosphatases II 229-354 1.2e-19 66.2 In-house 28-272 (297) alignment 
Range on Protein: 229-354
Range on HMM: 28-272/297.0
LGSWKSASNLEALK----------------------------------------------------------ALNITRIVNATASCDM------------
|||.. |...| |.                                                           .|.| ||. |   ..            
lgslsvallpenleknRykdilpydhtRVklddegsdYinAsyvdgydlkrkfIatqgPlpntvedFWrmvweqnvtvIvmltelvelgrekcaqywple

-----------------------------------PFDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQG------EGQRVLVHCQMGMSRSSALAIL
                                     ... .  |.   . |||.. . . ....|.....       .| .||||| .| .|| .....
egesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaa

WMM--------DFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEW
..|          . .....|. .. ..|| . ........| |.
dlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyea
0040439 (Phosphotyrosine protein) phosphatases II 235-355 1.1e-25 86.1 In-house 68-242 (249) alignment 
Range on Protein: 235-355
Range on HMM: 68-242/249.0
ASNLEALKALNITRIVNATASCDM-------------------------------------------PFDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVR
..... |. |.|| ||..|  . .                                            ...   .|| .  | |||.....| |...|..
edfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfie

KAQG------EGQRVLVHCQMGMSRSSALAILWMM-----DFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWE
...       .| .||||| .|..|. .......|       ....|..|.... |.||.. .||.....| |..
avrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeal
0045450 (Phosphotyrosine protein) phosphatases II 239-355 5.9e-24 80.8 In-house 125-300 (307) alignment 
Range on Protein: 239-355
Range on HMM: 125-300/307.0
EALKALNITRIVNATASCDMPF----------------------------DQQAVYLHCPLDDK-----------------PDHDLSQFFGDFIAFVRKA
. |. ...| ||. | .... .                            ..  .... .. |.                 |||.....| ....|....
rmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieev

QG------EGQRVLVHCQMGMSRSSALAILWMMDFHD--------MTLKQAYDYVHSKRPYINPNPGFLKQLGEWE
.       .| .||||| .|..|. .......|  .         ..| .|.... ..|| . .||.....| |..
rkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeal
0040438 (Phosphotyrosine protein) phosphatases II 239-355 2.1e-21 72.0 In-house 104-272 (317) alignment 
Range on Protein: 239-355
Range on HMM: 104-272/317.0
EALKALNITRIVNATASCDMP---------------------------FDQQAVYLHCPLDDK----------------PDHDLSQFFGDFIAFVRKAQG
. .. ...| ||. | ....                             ..  .... .. |.                |||.. . . ....|..... 
rmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavre

E----GQRVLVHCQMGMSRSSALAILWMM-----DFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWE
     |  ||||| .| .|. .......|       .......|.... ..||.. ..|.....| ...
aledpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydal
0039614 (Phosphotyrosine protein) phosphatases II 239-355 2.3e-19 65.4 In-house 119-285 (297) alignment 
Range on Protein: 239-355
Range on HMM: 119-285/297.0
EALKALNITRIVNATASCDMPF--------------------------------------------DQQAVYLHCPldDKPDHDLSQFFGDFIAFVRKAQ
. .. ...| ||. |  ...                                               ..  |.. |  |    .... . .|. .||.|.
rmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwp..dhgvppslellleflelvreal

G---EGQRVLVHCQMGMSRSSALAILWMM-----DFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWE
    .| .||||| .| .|. .......|       .......|.... ..||.. ..|.....| ...
aelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydal
0043336 (Phosphotyrosine protein) phosphatases II 240-354 2.4e-16 55.5 In-house 107-272 (278) alignment 
Range on Protein: 240-354
Range on HMM: 107-272/278.0
ALKALNITRIVNAT-----------------------------------------------ASCDMPFDQQAVYLHCPlDDKPDHDLSQFFGDFIAFVRK
 .. |..| ||. |                                                .    . ..  ||. | |..  ..||...    |. ..
mvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwp.dhgvpeslsllldflkavrea

AQGEGQRVLVHCQMGMSRSSALAILWMM-----DFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEW
 . ..  |||||  | .|. ....|...     . . ..| .|.... ..|| . ..| ....| |.
ledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyea
0047943 (Phosphotyrosine protein) phosphatases II 245-351 2.8e-14 48.7 In-house 101-264 (273) alignment 
Range on Protein: 245-351
Range on HMM: 101-264/273.0
NITRIVNATASCDM----------------------------------------------PFDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQG---
|.. ||  |   ..                                               ...  .. |    . |||.  . . ... |.....    
nvrviVmLtelvelgrekcaqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefielvrkale

---EGQRVLVHCQMGMSRSSALAILWMM-----DFHDMTLKQAYDYVHSKRPYINPNPGFLKQL
   ..  |.|||  | .|. ....|...       . .....|. .. |.||.. ..| ....|
alpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl
0051299 (Phosphotyrosine protein) phosphatases II 249-346 1.3e-11 40.0 In-house 120-273 (288) alignment 
Range on Protein: 249-346
Range on HMM: 120-273/288.0
IVNATASCDM-----------------------------------------------PFDQQAVYLHCPLDDKPDHDLSQFFGDFIAFVRKAQGE----G
||  |   ..                                               . ..   . |    . |||.  . . ....|.|...      |
IvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldflrlvrkalasgg

QRVLVHCQMGMSRSSALAILWMM-----DFHDMTLKQAYDYVHSKRPYINPNPG
  |.|||  | .|. ....|...       . ... .|. .. ..||.. ..| 
gpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtpe
0038934 (Phosphotyrosine protein) phosphatases II 260-356 1.9e-18 62.2 In-house 76-174 (194) alignment 
Range on Protein: 260-356
Range on HMM: 76-174/194.0
FDQQAVYLHCPLDDK---PDHDLSQFFGDFIAFVRkAQGEGQRVLVHCQMGMSRSSALAILWMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEH
 .    ||..|  |.   |. .. . | |.. ..  .. .|. |.||| .|..|.  |.. ...  ..|....|.... .||| . ||...|..| .. .
ekagieylklpfpddgtvPsleillrfldlvdefl.nedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkryk
0048567 (Phosphotyrosine protein) phosphatases II 260-343 5.8e-08 27.3 In-house 33-123 (157) alignment 
Range on Protein: 260-343
Range on HMM: 33-123/157.0
F--DQQAVYLHCPLDDKPD--HDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGM---SRSSALAILWMMDFHDMTLKQAYDYVHSKRPYINP
|  |.. ||..   |. |   . | .|.  .  | .  . .|... ||| .|.   .|.  |. ....  ...|  .|....   || . |
FsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvp
0050432 (Phosphotyrosine protein) phosphatases II 263-345 3.5e-11 38.4 In-house 150-285 (308) alignment 
Range on Protein: 263-345
Range on HMM: 150-285/308.0
QA----------------------------------------------VYLHCPLDDKPDHDLS---QFFGDFIAFVRKAQgEGQRVLVHCQMGMSRSSA
 |                                              .. |    . |||.     . . ||. .||| . .|  ..|||  | .|. .
caqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGt

LAILWMM-----DFHDMTLKQAYDYVHSKRPYINPNP
...|...       . ... .|. .. ..||.  ..|
fialdllleqlekeggvdvfeavkklReqRpgmvqtp
0046845 (Phosphotyrosine protein) phosphatases II 264-345 5e-10 34.7 In-house 165-260 (284) alignment 
Range on Protein: 264-345
Range on HMM: 165-260/284.0
AVYLHCPLDDKPDHDLS---QFFGDFIAFVRKAQGE---GQRVLVHCQMGMSRSSALAILWMMDFH--------DMTLKQAYDYVHSKRPYINPNP
    |    . |||.     . . .|. .||... .   |  ..|||  |..|. ....|...  .         ... .|. .. ..||.   ..
rtvthfhytswpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmvqtl
subfamily_PTPDC1_pd Subfamily PTPDC1 265-340 7.5e-06 20.5 In-house 84-157 (182) alignment 
Range on Protein: 265-340
Range on HMM: 84-157/182.0
VYLHCPLDDKPDHDLSQFFgDFIAFVRKAQGEGqRVLVHCQMGMSRSSALAILWMMDFHDMTLKQAYDYVHSKRPY
..  ....|   . | . . | .  |  |  || .| |||  |. |   |   ...  ...| ..| . | |||| 
yvynfgwkDygvasleriL.divkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpk
subfamily_Laforin_pd Subfamily Laforin 266-341 2e-06 20.8 In-house 79-154 (183) alignment 
Range on Protein: 266-341
Range on HMM: 79-154/183.0
YLHCPLDDKPDHDLSQFFGDFIAFVRKAQGEGQRVLVHCQMGMSRSSALAILWMMDFHDMTLKQAYDYVHSKRPYI
|.  |..|       . . . . ..     .|..| |||. |. ||.|.   ...   . .|..   .. .||| .
yiwlptedlstesrvenlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
subfamily_DSP11_pd Subfamily DSP11 266-351 6.6e-06 20.1 In-house 84-170 (178) alignment 
Range on Protein: 266-351
Range on HMM: 84-170/178.0
YLHCPLDDKPDHDLSQFFGDFI-AFVRKAQGEGQRVLVHCQMGMSRSSALAILWMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQL
 |.||  . |...| . | ...  |. | . ... . |||  |. |.  |   ...| ...  ..| .  .. | .      .||.|
klncpGhevpkeelvkkfkeavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeearGhslerenylkdL
subfamily_PTPMT1_pd Subfamily PTPMT1 285-356 1.6e-14 48.7 In-house 95-166 (171) alignment 
Range on Protein: 285-356
Range on HMM: 95-166/171.0
DFIAFVRKAQGEGQRVLVHCQMGMSRSSALAILWMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEH
. . |..| . .|.|| |||. | .||..|.. ..|  . .....| .....||..|. .   .|.| |.|.
kgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyee
subfamily_MSG5_pd Subfamily MSG5 286-357 1.2e-17 57.5 In-house 88-159 (165) alignment 
Range on Protein: 286-357
Range on HMM: 88-159/165.0
FIAFVRKAQGEGQRVLVHCQMGMSRSSALAILWMMDFHDMTLKQAYDYVHSKRPYINPNPGFLKQLGEWEHA
.   .  |. .....||||| |.|||..| . ..| .....|..||| ..|.   |.|. |.. || ||| |
ltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweva