Gene MbreMKP-Un-7 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP_MKP-unclassified
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP008_AA protein Get Run
MbreP008_AA_64-209 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
Rhodanese Rhodanese-like domain 2-49 2.1e-06 20.2 Pfam-A 15-78 (113) alignment
Range on Protein: 2-49
Range on HMM: 15-78/113.0
LVIDVRRRTAFEQARIQGAVHFDA----------------NQQSPLSVPALSHDFVVVYDDDGA
...|||   .... .|.|||...                 .. . .     ... ||||.  |.
vllDvRspeeyakghIpgAvnvpldslyprrdlffkdklaeeleesgkkldkdktvvvycrsgn

0044763 (Phosphotyrosine protein) phosphatases II 59-205 5.5e-33 109.5 In-house 15-169 (178) alignment
Range on Protein: 59-205
Range on HMM: 15-169/178.0
IGPSLRTFPSEIWPAfLFLGNKHHALDWSVVHDMGLTHIVNCSKE--------HPNAFADRGIRYFNVRVADEKFAL-SCPFETIPTSTDEVK-AQGGRC
.  |  . .|||.|  |.||.  .| |.  ....|.|||||...|        .| .. . ||.|... . | .    .  |. .    .|.   .||..
lersdyinaseilpg.lylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpv

LVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQgVRPNHGFLKQLADWEQR
||||..||.||...|.|||... . || || .||. .|  . || |.|.|| ..|.|
lVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelr

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 61-206 6e-74 240.5 In-house 1-147 (148) alignment
Range on Protein: 61-206
Range on HMM: 1-147/148.0
PSLRTFPSEIWPAFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRGIRYFNVRVAD-EKFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRS
..||||||||..||||||.|..|.|.......|.|.|||..||..||...|||.|..|...| .|..||..||.|.......|..|.|.|||..||||||
aaLrtfpseikdafLFlGskksaadlealkalgvtrivnatkerdnaldqrgieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrs

TACVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQRE
.|..|..||..||.||.||.||||.||..|.||.|||||||..||.|
salallwlidfkrvslkealalvkskrryvdpnlgfLkqLaeleqae

subfamily_STYXL1_pd Subfamily STYXL1 62-208 1.2e-25 83.6 In-house 6-155 (157) alignment
Range on Protein: 62-208
Range on HMM: 6-155/157.0
SLRTFPSEIWPAFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAF-ADRG-IRYFNVRVADEKFA-LSCPFETIPTSTDEVKAQGGRCLVHCTMGVSR
.|.|.|.|. | .|.||| ..| . .. .|. .   || |..  . . .. .  . ....| ||. | |   .. .    .. | .|   ||  . |.||
elktyPvevlPgklylGnykqaqnpaikkdlkvkahvnvsmdadkliagvadvakllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisr

STACVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQRELG
|.| ..|||.  |. .|..| . .|. .. |.||..|..|| .||.. ||
saaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekqllg

subfamily_MKPLT_pd Subfamily MKPLT 63-209 4.2e-35 114.7 In-house 17-163 (164) alignment
Range on Protein: 63-209
Range on HMM: 17-163/164.0
LRTFPSEIWPAFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFAdRGIRYFNVRVADEKF-ALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTA
....|| . .  |.||| .|| .  |..|. .||||| |.|. .||. . . | .|.| ||    ||  .| .     .    ||| ||||..|.|||..
ikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafp.ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsss

CVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQRELGS
. .|.||. |.  |.||   .|..|  |.|| ||||||| .|.  || 
vtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGk

subfamily_MKPLV_pd Subfamily MKPLV 63-209 4.2e-35 114.7 In-house 17-163 (164) alignment
Range on Protein: 63-209
Range on HMM: 17-163/164.0
LRTFPSEIWPAFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFAdRGIRYFNVRVADEKF-ALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTA
....|| . .  |.||| .|| .  |..|. .||||| |.|. .||. . . | .|.| ||    ||  .| .     .    ||| ||||..|.|||..
ikiypsvvledtlylGnakhatnekvlkdlkithivnvsqekkdafp.ksveYlqvkvedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsss

CVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQRELGS
. .|.||. |.  |.||   .|..|  |.|| ||||||| .|.  || 
vtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeelilGk

0041856 (Phosphotyrosine protein) phosphatases II 63-207 2.5e-28 94.3 In-house 17-173 (182) alignment
Range on Protein: 63-207
Range on HMM: 17-173/182.0
LrtFPSEIWPAfLFLGNKHH--------------ALDWSVVHDMGLTHIVNCSKEH--PNAFADRGIRYFNVRVADEKFALscpFETIPTSTDEVKAQGG
.  ....|..  |.||. ..              | ..  ....| |.|||.. |.  |. . . ||.|... . |        ....    .||...||
r..dldyInan.lylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpellerlgiqylylpwpDhgvpd...ldelldfieevleegg

RCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQ--GVRPNHGFLKQLADWEQREL
..||||..||.|. . |.|||..... ||.|| .||. .|    ..||..|. ||| .| ..|
pvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellll

subfamily_DSP6_pd Subfamily DSP6 64-205 2.5e-31 102.3 In-house 11-153 (158) alignment
Range on Protein: 64-205
Range on HMM: 11-153/158.0
RTFPSEIWPaFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRG-IRYFNVRVADEK-FALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTA
..|| || | .|.||....| .  |...... ...|  .. ||.|.. | ..| .. . |.    |.  |    .  || . .   .||||  |.||| .
aefpveilp.llylGsakdasnlevlkklkikyvlnvtsnlpnkfeesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvt

CVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQR
 .||||....  || .| .|||...  . ||  |..|| |.|..
vtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfers

subfamily_DSP1_pd Subfamily DSP1 65-207 1.3e-39 129.9 In-house 14-157 (163) alignment
Range on Protein: 65-207
Range on HMM: 14-157/163.0
TF-PSEIWPAFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADrGIRYFNVRVADEKF-ALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTAC
.. |.|.   ||.|| ...| . ......|.|.|.|.||| .|.| |   .| .. . |..   .|. ||..    ||||...|. |.|| .|.|||.. 
lydPvekildfLylGsetvasnleiLkslgitailnvskeldnvfed.lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstl

VLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQREL
.||||..||| || ||  .||..|. ..|| || .|| ..|...|
claylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkll

0048076 (Phosphotyrosine protein) phosphatases II 66-205 1.8e-28 94.4 In-house 3-141 (145) alignment
Range on Protein: 66-205
Range on HMM: 3-141/145.0
FPSEIWPAfLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFaDRGIRYFNVRVADEKFALS-CPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVL
.||||.|  |.||. ..|||.   .|.|.|...|.. | .. . . ||.|... . |     .   ....    .|. ..||..||||..||.|... |.
wpseilpg.lylgslptaldlellkdlgittvlnltselelle.rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtgtlva

AYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQR
|||..... || || .||. .| |. || |.|..| ..|..
aylmlllgvsleealelvrsqrpgavpnpgqlrflyefele

0048179 (Phosphotyrosine protein) phosphatases II 66-204 5.7e-28 92.8 In-house 3-142 (144) alignment
Range on Protein: 66-204
Range on HMM: 3-142/144.0
FPSEIWPAfLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADR-GIRYFNVRVADEKFALS-CPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACV
.||||.|  |.||.  .|||.   ...|.|...|.. |....|  | ||.|... . |     .   ....    .|. ..||..||||..||.|... |
npseilpg.lylgslptaldlellkklgittvinlteeyepefleregiqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlv

LAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
.|||..... || || |||. .| |. || |.|..| ..|.
aaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek

0045098 (Phosphotyrosine protein) phosphatases II 66-207 3.8e-24 81.0 In-house 20-272 (278) alignment
Range on Protein: 66-207
Range on HMM: 20-272/278.0
FPSEIWPAFLFLGNKH-----------------------------------------HALDWSVVHDMGLTHIVNCSKEHP-------------------
..   .  .|.|||..                                         .| .|  ....| |.||.. ....                   
gipseitpalylgnldknRykdilpydhsrVkdYINAsyidgypkkfIatqgPlpstvadfwrmlwelgitvivmltelvelgrekcaqywpeggsltyg

-----------------------------NAFADRGIRYFNV-RVADEKFALSC---PFETIPTSTDEVKA--------------QGGRCLVHCTMGVSR
                             . .  ||.....   . |     .    .|  .    .|. .              .||..|||| .||.|
dftvtllseevlddytlrtllvtnltveredlesrgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgR

STACVLAYLIRTK---RKSLREAAALVKDKRQG-VRPNHGFLKQLADWEQREL
. . |.|||...    . .| || . .. .| | . .| .....| ..... |
tGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrflyefllell

subfamily_LRR-DSP_pd Subfamily LRR-DSP 66-204 1.3e-23 77.4 In-house 119-256 (263) alignment
Range on Protein: 66-204
Range on HMM: 119-256/263.0
FPSEIWPAfLFLGNKHHALDWSVVHDMGLTHI----VNCSKEHPNAFadrgiRYFNV---RVADeKFALSCPFETIPTSTDEVKAQGGrCLVHCTMGVSR
 |.|| .  |||| .. | . |...|.|.|||     ..   .|. |     .|. .   . .| .. .|  || . .  .| . .||  ||||  ||||
vPdeiidk.lflGgldsannksilkdlgvthillavadfePlfPklf.....kylsiddiedvd.eadisqhfeetnafieeGrkkGG.vlvhcraGvsr

STACVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
|.. |..||.. .|  ..||  ||. ||  ..||.||..||  .|.
sstlvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek

PTEN_1 66-200 4.1e-20 67.4 In-house 35-185 (196) alignment
Range on Protein: 66-200
Range on HMM: 35-185/196.0
FPSE----IWPAFLFLGNKHHA-LDWSVVHDMGLTHIVNCSKEHPN--------AFADRGIRYFNVRVADEK-FALSCPFETIPTSTDEVKA--QGGRCL
.||.     .. .|..|. ...  |.   . .|.|..|| | | ..         | ..|..| .. . |     ||. |. .    . ...  .|. .|
apsrpllqeideglyrgslkdvaadldnlkedgitlvvnlseeeelsgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVl

VHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLA
|||. |..||   | |||..... . .|| .||..||  ..|| .....| 
VHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerll

PTPc_motif_SM00404 67-204 4.9e-32 105.7 In-house 2-139 (140) alignment
Range on Protein: 67-204
Range on HMM: 2-139/140.0
PSEIWPAfLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRGIRYFNVRVAD-EKFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLA
||.| |  |.||.| .| .  .   .|.||..|...| ..  .. |...... . | || .||  .. . .  ......||..||||..||||| . ..|
psrilph.lylgskskaqnpallkklgithvinvteevsltkensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliia

YLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
||.|..  ||.||  .||..|. ..|| .|..|| ..|.
YlmryrqlslaeayefvkerRpiispnlnfvrqLieyek

subfamily_Slingshot_pd Subfamily Slingshot 67-203 6.7e-31 101.0 In-house 19-154 (169) alignment
Range on Protein: 67-203
Range on HMM: 19-154/169.0
PSEIWPaFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRgIRYFNVRVADEK-FALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLA
.|.|.  ...||    | ..  ....| ..|.| .||  | |... ..|.|.|| ||.   |   ...  .  ...|..| ..|||| ||||||.. |.|
askifd.hvylGsewnasnleelkengveyilnvtkeidnffpek.feylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastvia

YLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWE
| ... . || || . ||..|. ..||.||||||  .|
yamkeyglsleealeyvkerrsvikPnkgflkqleeye

subfamily_DSP10_pd Subfamily DSP10 68-205 1.7e-31 103.3 In-house 15-152 (159) alignment
Range on Protein: 68-205
Range on HMM: 15-152/159.0
SEIWPaFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRGIRYFNVRVADE-KFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAY
|.. | |||||... | | .... ...|...|  .. || |.. ...|  . | |  |  |.  ||      .|.. .| | ||||  |.|||.. |.||
sqvlp.fLflGsekdaadldaldrlnitavlnvttsvPnefeeealkYkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaY

LIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQR
|.. .. ||..|  .||.||  . || .|. || ..|..
lmkhlnlslndaykfvkekrpiisPnLnfmGqLlefeke

subfamily_DSP3_pd Subfamily DSP3 68-205 2.1e-31 102.7 In-house 12-156 (162) alignment
Range on Protein: 68-205
Range on HMM: 12-156/162.0
SEIWPAfLFLGNKHHALDWSVVHDMGLTHIVNCSKE-------HPNAFADRGIRYFNVRVADE-KFALSCPFETIPTSTDEV-KAQGGRCLVHCTMGVSR
 |..|  |..|... | | | .. .|.||..|...        ... . | .|.|. . | |  .| ||  |||     ||  . . |. ||||..||||
devypk.lyvgdeavakdkskLkklGithvlnaaegrfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsR

STACVLAYLIRTKRKSLREAAALVKDKRQgVRPNHGFLKQLADWEQR
|...|||||. ... .| ||   |..||. ..||.|||||||. ...
satlvlayLmirrkmtlveairtvrkkRe.ilPneGFlkqLaeldee

subfamily_DSP8_pd Subfamily DSP8 68-204 5.1e-24 78.6 In-house 16-152 (159) alignment
Range on Protein: 68-204
Range on HMM: 16-152/159.0
SEIWPaFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRGIRYFNVRVADEKF-ALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAY
 .| . .|.|| ....|. ......|.....| |.. |.    .  ... | | |.    |.  |..     | .|.. ||.|||.  | |||.. ..||
trilk.nlylGsqkdvlseellsklgisyvlnasnscpkleelkeskflrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatvaiay

LIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
...| . || ||   ||.||. . ||  ||.|| ..|.
imktlemsldeayrfvkekrptispnlnflgqLleyek

0046846 (Phosphotyrosine protein) phosphatases II 68-205 1e-23 79.4 In-house 13-171 (176) alignment
Range on Protein: 68-205
Range on HMM: 13-171/176.0
SEIWpAFLFLGNKH----------HALDWSVVHDMGLTHIVNCSKEH----------PNAFADRGIRYFNVRVADEKFALSCPFETIPTSTDEVKAQGGR
..|. | |.||..           .| ..  ....| |..||. .|.          .. . . ||.|... . |     .  ....    .|.  .||.
dyin.anlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeggp

CLVHCTMGVSRSTACVLAYLIRT-KRKSLREAAALVKDKRQ-GVRPNHGFLKQLADWEQR
 |||| .|..|. . |.|||... |  |. || |||...|  |. .. .....| ..|..
vlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell

0037934 (Phosphotyrosine protein) phosphatases II 68-203 3.8e-20 67.9 In-house 40-238 (243) alignment
Range on Protein: 68-203
Range on HMM: 40-238/243.0
SEIWPaFLFLGNK--------HHALDWSVVHDMGLTHIVNCSKEH--------------------------------------------PNAFADRGIRY
....|  |....         ..| .|  ... | |.||.. ..                                             .. .   .|.|
iyvtp.rliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihy

FNVRVAD----E-KFALSCPFETIPTSTDE-----VKAQGGRCLVHCTMGVSRSTACVLAYLIRTK-RKSLREAAALVKDKRQG-VRPNHGFLKQLADWE
  . . |    .    |   .. . .  .|     .  .||..||||..||.|. . ..|||. .. . .| || .|....| | . .. .....| ...
hylpwpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeal





0051429 (Phosphotyrosine protein) phosphatases II 68-206 3.4e-16 55.2 In-house 17-224 (272) alignment
Range on Protein: 68-206
Range on HMM: 17-224/272.0
SEIWPAFLFLGNKH---HALDWSVVHDMGLTHIVNCSKEHPNAFAD-----RGIRYFNVRVADEKFALS-------------------------------
....| .|....      | |.   ...|...||.  .|.  .. .      ||||... . |. .                                  
rvvkpgrlyrsggplpltaadfwrlkelgiktivdLrseeErgrlkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsa

------------------CPFETIPTSTDEVKAqGGRCLVHCTMGVSRSTACVLAYLIRtKRKS--------------LREAAALVKDKRQGVRPNHGFL
                   | |.. .  ... . ||..||||. |..|.   |...|.   . |              |.|| . ....| |.... ...
gearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqy

KQLADWEQRE
..| ....  
lflyeallel

0051082 (Phosphotyrosine protein) phosphatases II 69-202 1e-18 62.8 In-house 10-149 (151) alignment
Range on Protein: 69-202
Range on HMM: 10-149/151.0
EIWPAfLFLGNKHHALDWSVVHDMGLTHIVNCSKEH-----PNAFADRGIRYFNVRVADEKFA-LSCPFETIPTSTDEVKAQ-GGRCLVHCTMGVSRSTA
 ...  |....  .| ..  ....|...|||. .|.     |. . . ||..... . | ..  |.  |...    ... .. .| .||||..|..|. .
yvtgg.lyrsggpladflellkelgiktivnlrseeergycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTGt

CVLAYLIRtKRKSLREAAALVKDKRQ-GVRPNHGFLKQLADW
 |..||.   . || || . .. ||   |.|| .||.|| ..
lvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlfal

subfamily_STYX_pd Subfamily STYX 69-205 4.1e-18 59.0 In-house 14-156 (166) alignment
Range on Protein: 69-205
Range on HMM: 14-156/166.0
EIWPAfLFLGNKHHALD--WSVVHDMGLTHIVNCSKEHPNAFA----DRGIRYFNVRVADEKFA-LSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTA
|| |  ||||    |.     |... |.||||   ..   ..     .  .||. . |||.    .   . |. .  |.   .||. |||   |.|||.|
eilpg.lflgpysaamksklevlkkhgithivcirqnieanlikpnfpdrfrylvldvadntveniirylptvkefiddslqkggkvlvhgnagisrsaa

CVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQR
 |.||.. |     ||| | |...|  . ||.|| .|| ..|  
lviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeai

0049772 (Phosphotyrosine protein) phosphatases II 70-206 2.8e-27 91.7 In-house 155-273 (314) alignment
Range on Protein: 70-206
Range on HMM: 155-273/314.0
IwpaflflgNKHHALDWSVVHdmglthivncsKEH--PNAFADRGIRYFNVRVADEKFAlscPFETIPTSTDEVKA--QGGRCLVHCTMGVSRST-ACVL
         |  .| |.   .           .|.  |. | ..||.|... | |. .    ..| ..   . ...  .||. ||||..|..|.. ..|.
g........neptaadlellk...........eelydpelferlgikylripvpDgsap...lledfdeflefieeadkggpvlvHCkaGkgRtgtfvva

AYLIRTKRKSLREAAALVKDKRQgVRPNHGFLKQLADWEQRE
|||..  . ||.|| . |. ||  ..||.||..|| ..|...
aylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil

0036282 (Phosphotyrosine protein) phosphatases II 70-204 2.9e-22 74.6 In-house 15-167 (174) alignment
Range on Protein: 70-204
Range on HMM: 15-167/174.0
IWPaFLFLGNKHHAlDWSVVHDMGLTHIVNCSKEHPNA--------------FADRGIRYFNVRVADEKFALSCPFETIPTSTDEVKAQ--GGRCLVHCT
|.|  |..|.  .| .|  ... |.|..|.. .|...               . . ||.|. . . |     .  ....    .|. ..  || .||||.
itp.rliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsillefvkfveealsedpggpvlVHCs

MGVSRSTACVLAYLIRTKRK-SLREAAALVKDKR---QGVRPNHGFLKQLADWEQ
.||.|. . |.|||. .  . ||..| .||. .|    |. .. .....| ..|.
aGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfek

0043147 (Phosphotyrosine protein) phosphatases II 73-205 2.4e-27 91.2 In-house 24-159 (172) alignment
Range on Protein: 73-205
Range on HMM: 24-159/172.0
AFLFLGNKHHALDWSVVHDMGLTHIVNCSKE--HPNAFADRGIRYFNVRVADEKFALSCPFETIPTSTDE--VKAQGGRCLVHCTMGVSRSTACVLAYLI
|...... ..| .|  ....| |||||. ..   |  . . ||.|  . . |    |.  .. .    ||  .. .||..||||..||.|. . |.|||.
atqgplrntladfwrmlkelgithivnltellydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylm

RtKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQR
. .. || || |||..|| |. .| .....| ..|..
l.lglsleeavalvrekRpgavqnpsqyrflyyfekl

0049260 (Phosphotyrosine protein) phosphatases II 73-204 1.2e-23 78.9 In-house 13-147 (152) alignment
Range on Protein: 73-204
Range on HMM: 13-147/152.0
AFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNA--FADRGIRYFNVRVADEKFALSCPFETIPTSTDEV--KAQGGRCLVHCTMGVSRSTACVLAYLI
|....|. ..| .|  ....| |.||.. ......  . ...|.|... . |     .  .  .    .|   . .||..||||. ||.|. . |.|||.
atqgpgpntladfwrmlkelgittivmltellelgklkceqyiqylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylm

RtKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
. .. || || |||. || |. ||.|.|..| ..|.
l.lgvsleeavalvrekRpgavpnpgqlrflyefek

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 73-205 4e-22 72.2 In-house 8-151 (154) alignment
Range on Protein: 73-205
Range on HMM: 8-151/154.0
AFLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADR--------GIRYFNVRVADEKF-----ALSCPFETIPTSTDEVKAqgGRCLVHCTMGVSRS
 ||...  . ||.   ..   ...|.|..   .|.|.|.         | | |... |.        |.  || |  .   |.   .. |||.  |||||
iflyissfdaalnkldlqlkniksilnvgiGinnlftdensdindgfiieylnlelfddvnfdiiekldkafefiddaiggven..nkvlvhsdkGvsrs

TACVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQR
.| ...||.  .. || .|  |.|| |  ..||.||||||  .|..
aallisylmdklkislslalellkdsryiikPnqGflkqleifeke

subfamily_DSP14_pd Subfamily DSP14 74-209 3.5e-35 115.3 In-house 13-147 (157) alignment
Range on Protein: 74-209
Range on HMM: 13-147/157.0
FLFLGnKHHALDWSVVHDMGLTHIVNCSKEHPNaFADRGIRYFNVRVADEK-FALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKR
 |||.    ||. ....  ..|.|.|.. | ||    ..|.. .|.|.|..   |.  |...  . .|||..||..||||..||||| . .||||.....
sLfls.gvaalskellkkkkitliinvtvelpn.tklkdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyek

KSLREAAALVKDKRQGVRPNHGFLKQLADWEQRELGS
.|||||  |||..|  .||| || ||| |.|..  |.
lsLreayklvksaRpiirPNvGFwkqlidyEkklkgk

subfamily_DSP19_pd Subfamily DSP19 74-205 3.2e-29 96.2 In-house 18-149 (152) alignment
Range on Protein: 74-205
Range on HMM: 18-149/152.0
FLFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADRgIRYFNVRVADEK-FALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKR
 |.|| .  | | . ..  ..|||.| . . ||.|..  . | .. . |..   |.  ....    .|.. . |. ||||  |||||.. |.|||.....
rlylgsqdvaadkeilkekkitHilnvatgvpnvfpkd.ftylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkee

KSLREAAALVKDKRQGVRPNHGFLKQLADWEQR
.||.||  ||...|. ..||.||.||| ..|..
lsleealelvrearpcikPneGFikqLkeyeae

DSPc Dual specificity phosphatase, catalytic domain 75-204 1.5e-30 100.8 Pfam-A 1-132 (133) alignment
Range on Protein: 75-204
Range on HMM: 1-132/133.0
LFLGNKHHALdWSVVHDMGLTHIVNCSKEHPN--AFADRGIRYFNVRVAD-EKFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTK
|.||.| .|   ..  ..|.|...|..|| ||  |...  |.|... | | .. ..|  .| . .  ......|...||||..|.||| . ..|||..||
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
. ||.|| ..||..|. ..|| |||.|| ..|.
nlslneAyefvkerrskispnagflrqLleyer

DSPc Dual specificity phosphatase, catalytic domain 75-204 1.5e-30 100.8 In-house 1-132 (133) alignment
Range on Protein: 75-204
Range on HMM: 1-132/133.0
LFLGNKHHALdWSVVHDMGLTHIVNCSKEHPN--AFADRGIRYFNVRVAD-EKFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTK
|.||.| .|   ..  ..|.|...|..|| ||  |...  |.|... | | .. ..|  .| . .  ......|...||||..|.||| . ..|||..||
lylgskstas.lalleklgitlvinvtkevpnnnaikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktk

RKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
. ||.|| ..||..|. ..|| |||.|| ..|.
nlslneAyefvkerrskispnagflrqLleyer

subfamily_DSP12_pd Subfamily DSP12 75-205 9.2e-25 81.8 In-house 9-142 (155) alignment
Range on Protein: 75-205
Range on HMM: 9-142/155.0
LFLGNKHHALDWSVVHDMGLTHIVNCSKEH-PNAFADRGI-RYFNVRVADEKFA-LSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTK
|.||. ... . .  .....||..   ||. |.  ...|  .. .. ..||  . .   .... .  .|  ...|  ||||..||||| . |.|||....
lylggleavqeeellkelkithvlsvikeelpehklkkgkvstkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkke

RKSLREAAALVKDKRQGVRPNHGFLKQLADWEQR
. || .|  |||.|.. ..||.|||.||  .|. 
klslekAlklvkekkpeiepNegFleQLklfekm

subfamily_DSP15_pd Subfamily DSP15 75-207 7.4e-22 72.1 In-house 9-140 (151) alignment
Range on Protein: 75-207
Range on HMM: 9-140/151.0
LFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFADrgIRYFNVRVADE-KFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKRK
|.||| . . |   ...  .|||.. . .  . . |  |.|  ....|  .  ||  |.       . . ... .|||| .|||||.  | |||.     
lylgnfrdskdeelLkeknithilsvhdnakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtel

SLREAAALVKDKRQGVRPNHGFLKQLADWEQREL
. |.|   .| .|.   || || .|| ..|. .|
nwrdalevikaaRsvanPnfGfkrqlkeyektkl

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 75-203 3.5e-15 49.4 In-house 6-138 (145) alignment
Range on Protein: 75-203
Range on HMM: 6-138/145.0
LFLGNKHHALDWSVVHDMGLTHIVNCSKEHPNAFA---DRGIRYFNVRVAD-EKFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRT
|. |   || | ......|.. ||| .  .  |      . |  . .   | | . ||  |. .    |  | .|   .|||  ||||| .  .|.|.. 
lyvgsalhandvptlqelgisrivnmaagslvasqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmky

KRKSLREAAALVKDKRQGVRPNHGFLKQLADWE
   .| |||  |. .|    ||  |||.| . |
cnmtlseaarqvrsnrllaypnvtflknllnle

0040439 (Phosphotyrosine protein) phosphatases II 82-204 5.8e-20 67.4 In-house 67-243 (249) alignment
Range on Protein: 82-204
Range on HMM: 67-243/249.0
HALDWSVVHDMGLTHIVNCSKEHPN-----------------------------------------------AFADRGIRYFNVRvadeKFALSCPFETI
 . .|  ... | |.||..... ..                                                .  ..|.|..       . ..  ||..
vedfwrmlwelgitvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwp....dhgvppsfedl

PTSTDEVKA------QGGRCLVHCTMGVSRSTACVLAYLI-----RTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
    ..|.       .||..||||..||.|. . ..|||.     .... .| || .|....| |. .| .....| ....
ldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrflyeall

0042113 (Phosphotyrosine protein) phosphatases II 82-204 2e-19 65.4 In-house 65-240 (245) alignment
Range on Protein: 82-204
Range on HMM: 65-240/245.0
HALDWSVVHDMGLTHIVNCSKEH---------------------------------------------PNAFADRGIRYFNVRVADEKFAL-SCPFETIP
 .  |  ... |.|.||....|.                                             .. .   .|.|. . . | . .  .  .. . 
vedfwrmlwelgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldfl

TSTDEVKA--QGGRCLVHCTMGVSRSTACVLAYLI-----RTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
   ... |  ..|..||||..||.|. . ..|||.     .... || || . ....| |.... .....| ....
efvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

0045450 (Phosphotyrosine protein) phosphatases II 86-204 5.3e-20 67.8 In-house 124-301 (307) alignment
Range on Protein: 86-204
Range on HMM: 124-301/307.0
WSVVHDMGLTHIVNCSKEHPNAF---------------------------ADRGIRYFNVRVADE------------------KFALSCPFETIPTSTDE
|  ... | |.||..... ....                            . |. .....| |                    . ..  ||..    .|
wrmlweqgvtvivmltelvelgrekcaqywPdegeeltygnftvtllseehldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfiee

VKA------QGGRCLVHCTMGVSRSTACVLAYLIRTKR--------KSLREAAALVKDKRQGVRPNHGFLKQLADWEQ
|..      .||..||||..||.|. . ..|||. . .         .|.|| .|....| |. .| .....| ....
vrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyeall

0040438 (Phosphotyrosine protein) phosphatases II 86-206 1.4e-18 62.7 In-house 103-275 (317) alignment
Range on Protein: 86-206
Range on HMM: 103-275/317.0
WSVVHDMGLTHIVNCSKEHPNA--------------------------FADRGIRYFNVRVAD-----------------EKFALSCPFETIPTSTDEVK
|  |.. |.|.||.  .. ..                           . . || .....| |                   . .   ....    ..|.
wrmvweqgvtvivmLteleelgrekcaqYwplgetltygdftvtllseeelagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavr

AQ----GGRCLVHCTMGVSRSTACVLAYLI-----RTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQRE
..    || .||||..||.|. . ..|||.     .... .. || . .. .| |. .. .....| |...  
ealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalley

0039614 (Phosphotyrosine protein) phosphatases II 86-210 1.3e-17 59.6 In-house 118-292 (297) alignment
Range on Protein: 86-210
Range on HMM: 118-292/297.0
WSVVHDMGLTHIVNCSKEHPNAF--------------------------ADRGIRYFNVRVADEK-----------FALSCP--FETIPTSTDEVKA---
|  |.. | |.||.  |. ..                            ..  .|...|.  .|               ..|  .|..    ..|.    
wrmvweqgvtvivmLtklvelgrkcaqywpeeggtygdftvtllkvehldgytvrtlevtnngesrtvthfqytgwpdhgvppslellleflelvreala

---QGGRCLVHCTMGVSRSTACVLAYLI-----RTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQRELGSR
   .||..||||..||.|. . ..|||.     .... .. || . .. .| |.... .....| |...  |  .
elpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydallellkrk

0036941 (Phosphotyrosine protein) phosphatases II 86-209 5.1e-16 54.3 In-house 95-279 (297) alignment
Range on Protein: 86-209
Range on HMM: 95-279/297.0
WSVVHDMGLTHIVNCSKEHPNA--------------------------------FADRGIRYFNVRVADEK-------------FALSCP--FETIPTST
|  |.. . |.||. ... ..                                 ..|  .|.. |   ...                ..|  ....    
WrmvweqnvtvIvmltelvelgrekcaqywpleegesltygdftvtllsvevvllddytlrtlevtdtgngesrtvthfhytgwpdhgvpespaslldfi

DEVKA------QGGRCLVHCTMGVSRSTACVLAYLI--------RTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWEQRELGS
..|.       .||. |||| .||.|| . ..|.|.        .... .. ||   ....| |. .. .....| ....  | .
elvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyeallellkk

0043336 (Phosphotyrosine protein) phosphatases II 86-203 1.5e-14 49.6 In-house 105-273 (278) alignment
Range on Protein: 86-203
Range on HMM: 105-273/278.0
WSVVHDMGLTHIVNCSKEH--------------------------------------------PNAFADRGIRYFNVRVADEKFA--LSCPFETIPTSTD
|  |.. | |.||.  ..                                              . .   . .|  . . | ..   ||  .. . .  .
wrmvwelgvttivmLtelvelgrvkcaqYwpggsltygdftvtllkeehlddytvrtlevtnlgdgesrtvthyhylgwpdhgvpeslsllldflkavre

EVKAQGGRCLVHCTMGVSRSTACVLAYLI-----RTKRKSLREAAALVKDKRQGVRPNHGFLKQLADWE
 .. ..|  ||||. ||.|. . ...||.     .... .| || . .. .| |  ..  ....| ...
aledsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeal

0047943 (Phosphotyrosine protein) phosphatases II 86-199 3.7e-10 35.2 In-house 94-264 (273) alignment
Range on Protein: 86-199
Range on HMM: 94-264/273.0
WSVVHDMGLTHIVNCSKEHPNAFADrGIRYFNVRVAD---------------------------------------------EKFALSCP--FETIPTST
|  |.. . ..||   ... .   .   .|.   . .                                             .    ..|  .| . .  
wrmvweqnvrviVmLtelvelgrek.caqYwpleggelsltygkftvtllseetkddytvrtleltnlgtgesrtvthfhytgwpdhgvppslesllefi

DEVKA------QGGRCLVHCTMGVSRSTACVLAYLI-----RTKRKSLREAAALVKDKRQGVRPNHGFLKQL
..|.       ..|  .|||  ||.|. . ....|.     .... .. || .|....| |. ..  ....|
elvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl

0050432 (Phosphotyrosine protein) phosphatases II 86-193 2e-08 29.4 In-house 125-285 (308) alignment
Range on Protein: 86-193
Range on HMM: 125-285/308.0
WSVVHDMGLTHIVNCSKEHPNA-------------------------------FADRGIRYFNVRV-----------------ADEKFALScpFETIPTS
|  |.. . ..||   |.. |                                ..|  .|.. ..                   | .   |  .| . . 
wrmvweqnvrvIvmLtklvengrekcaqYwplelgggsleygkftvtllseevlddytvrtleltnlgdgesrtvthfhytnWpdhgvPps..peilldf

TDEVKAQ--GGRCLVHCTMGVSRSTACVLAYLI-----RTKRKSLREAAALVKDKRQGVRPNH
 ..|. .  || ..|||  ||.|. . ....|.     .... .. || . .. .| |. .. 
lelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgmvqtp

0051299 (Phosphotyrosine protein) phosphatases II 86-193 2.9e-08 29.0 In-house 109-272 (288) alignment
Range on Protein: 86-193
Range on HMM: 109-272/288.0
WSVVHDMGLTHIVNCSKEHPNA----------------------------FADRGIRYFNVRVA----DEKF-------------ALSC--PFETIPTST
|  |.. . ..||   |.. .                             ..|  .|.. |.       ...               ..   .| . .  
WrmvweqnvrvIvmltklvelgrekcaqYwplggsltygditvtllseevlddytvrtlevtnldlldgdgesrtvthfhytnwpdhgvpdspellldfl

DEVK----AQGGRCLVHCTMGVSRSTACVLAYLI-----RTKRKSLREAAALVKDKRQGVRPNH
 .|.    ..|| ..|||  ||.|. . ....|.     .... .. || . .. .| |. .. 
rlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqtp

subfamily_DSP23_pd Subfamily DSP23 89-188 2.9e-07 25.2 In-house 27-127 (148) alignment
Range on Protein: 89-188
Range on HMM: 27-127/148.0
VHDMGLTHIVNCSKE-HPNAFADRGIRYFNVRVADEKFALSCPFETIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQ
. |.|. ..|  ..| .|.. |  .. . ..|. | .       . .    .| ....    ||| .|  |. . .  ||.. .. .  || | |. .| 
lldlgvrylvslteegrphveatpnltlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlrp

G
|
g

0046845 (Phosphotyrosine protein) phosphatases II 89-190 6.8e-07 24.4 In-house 97-257 (284) alignment
Range on Protein: 89-190
Range on HMM: 97-257/284.0
VHDMGLTHIVNCSKEHPNA-----------------------------FADRGIRYFNVRVAD-EKF-------------ALSCP--FETIPTSTDEVKA
|.. . ..||   ... |                              . |  .| . ..  . ...               ..|  .| . .  ..|. 
vweqnvrvIVmltelvengrekcaqYwplegevltygdftvtllseevkddytvrtleltnlgytgesrtvthfhytswpdhgvppspedlleflrlvre

Q------GGRCLVHCTMGVSRSTACVLAYLIRTK--------RKSLREAAALVKDKRQGVR
.      ||  .|||  ||.|. . ....|. .         . .. || . ....| |  
llenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpgmv

subfamily_PTPMT1_pd Subfamily PTPMT1 90-204 4.8e-12 40.6 In-house 55-166 (171) alignment
Range on Protein: 90-204
Range on HMM: 55-166/171.0
HDMGLTHIVNCSKEHPNAfadrGIRYFNVRVADekFALSCPFETIPTS---TDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKR
..  |....|...|. .     |. ...... |  |. .  .|..  .    ..|. .| |  |||  | .||.. | .||. ... |. ||   .|.||
eeyelkalansteewkkl....gveqlqlatvD..fteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkR

QGVRPNHGFLKQLADWEQ
. .| ..  .|.|  .|.
kiirlakkqwkalqeyee

0038934 (Phosphotyrosine protein) phosphatases II 92-202 2.1e-17 58.9 In-house 55-172 (194) alignment
Range on Protein: 92-202
Range on HMM: 55-172/194.0
MGLTHIVNCSKE----HPNAFADRGIRYFNVRVADEKFAlsCPFETIPTSTDEV-----KAQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALV
..|..... ...    .|. | ..||.| .  . |  ..   ..|.. .  | |     . .|| ..|||..|..|.   | |||| . . |..|| ||.
vklglvidltnteryYdpeefekagieylklpfpddgtv..PsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialf

KDKRQGVRPNHGFLKQLADW
..||.|. || ..|..|  .
rekRpgaipnqdyleallkr

subfamily_MSG5_pd Subfamily MSG5 97-204 3.6e-14 46.2 In-house 51-158 (165) alignment
Range on Protein: 97-204
Range on HMM: 51-158/165.0
IVNCSKEHPNA-FADRGIRYFNVRVA-DEKFALSCPfeTIPTSTDEVKAQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQGVRPNHG
..| .|| ..  .    ..|. ..   | | ..  .  .. .     .... . ||||  |.|||.. ..||...    |||.|  ..| . . . |. |
vinvakeindlellvpavkyyhiewehdskivkdls..rltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsig

FLKQLADWEQ
.. || .|| 
lifqlmewev

subfamily_PTPDC1_pd Subfamily PTPDC1 105-201 3.3e-06 21.7 In-house 75-170 (182) alignment
Range on Protein: 105-201
Range on HMM: 75-170/182.0
PNAFADRGIRYFNVRVADEKF-ALSCPFETIPTStDEVkAQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQGVRPNHGFLKQLAD
..|....|| ..|.  .| .  .|   .. .    . .  | |.  |||  |  |    . .||. .|| .  .|  ||..||      .. .. . .
lealmeqgiyvynfgwkDygvasleriLdivkvv.afa.lqegkvavhChaGlGrtGvliacylvyakrltaekaiklvrskrpksiqtreqvelvke

0048567 (Phosphotyrosine protein) phosphatases II 105-192 8.7e-06 20.2 In-house 30-124 (157) alignment
Range on Protein: 105-192
Range on HMM: 30-124/157.0
PNAF-ADRGIRYFNVRVADEKFALSCPF---ETIPTSTDEVKAQGGRCLVHCTMGV---SRSTACVLAYLIRTKRKSLREAAALVKDKRQGVRPN
.  |  |.|. |..    .  . |.. .     .    . .. .|..  |||..|    .|.   . .|||   ... .|| |...  |.|  | 
alyFsiddglvyedfffdfGPlnlailyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpf

subfamily_Laforin_pd Subfamily Laforin 143-187 8e-06 18.9 In-house 108-152 (183) alignment
Range on Protein: 143-187
Range on HMM: 108-152/183.0
AQGGRCLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQ
 .| .  |||  || |||| |  .|      ||.     .  || 
ekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrp

subfamily_RNGTT_pd Subfamily RNGTT 148-200 6.4e-06 20.0 In-house 116-168 (189) alignment
Range on Protein: 148-200
Range on HMM: 116-168/189.0
CLVHCTMGVSRSTACVLAYLIRTKRKSLREAAALVKDKRQ-GVRPNHgFLKQLA
  |||| |  |.   . .||. ..  |...| || .  |. |.  .. .||.|.
igvhCthGfnRtGFlivsyLvekedwsveaavalFakaRppGiyked.ylkell