Gene DSP12 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily DSP12
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP011_AA protein Get Run
MbreP011_AA_0-150 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
subfamily_DSP12_pd Subfamily DSP12 1-157 1.2e-56 185.4 In-house 2-154 (155) alignment
Range on Protein: 1-157
Range on HMM: 2-154/155.0
MSRVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSwywFGHRLLPSTVRrQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSA
.||...|||.|.|| .|...|. ||....... ....    . |.| ...|. .|.| ..||...||||.|.||.||||.|..|.| |.||||||||||.
vsrilpglylggleavqeeellkelkithvlsvikeel...pehklkkgkvs.tkfiqilDepeediLshldeavdFieealeeegavlvHCqagvSRSv

TVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMKCTLDDSNPDYR
|.|.||||.. .|...||....|.... . || ||..||.|||||.|..|.||..|.
tiviAYlmkkeklslekAlklvkekkpeiepNegFleQLklfekmgckvdtsnkayk

PTPc_motif_SM00404 1-145 4e-31 102.8 In-house 2-140 (140) alignment
Range on Protein: 1-145
Range on HMM: 2-140/140.0
MSRVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYwfghrllpS--TVRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSR
.||. ..||.||..  |. ||. .||.. .   .   |.         .    .. ..| . |.|..... .|...|||||.|... | |.|||||||||
psrilphlylgskskaqnpallkklgithvinvteevslt........kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSR

SATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
|||...|||||  .|. ..|....|       || .| .||  .||.
SatliiaYlmryrqlslaeayefvkerRpiispnlnfvrqLieyekk

0044763 (Phosphotyrosine protein) phosphatases II 1-148 9.3e-31 102.2 In-house 23-172 (178) alignment
Range on Protein: 1-148
Range on HMM: 23-172/178.0
MSRVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYWFGH--RLLPSTVRRQKSILVFDEEQADILSWLPEALDFIESAR-SEDGIVYVHCQAGVS
.|....|||.|||   .| .|. |||...|   ..   .. ...    . ..  . . | . |    |.|....|...|||.|. ...| |.|||.|||.
aseilpglylgslppaddlellkelgithivnlteelelgflkcdpywpeeagiqylhipipDhgvpdllehflefvefieealdekggpvlVHCsaGvg

RSATVVMAYLMRNLGLNCSKAFRMLKAAHRpALPNPGFQQQLRLFEKMKCT
||.|.|.||||. |||.  .|....... . . ||||...||..||.. . 
RsgtlvaaylmkklglsleeaielvrerRp.ivpnpgqlrqLyefelrllk

0048076 (Phosphotyrosine protein) phosphatases II 1-145 2.1e-28 94.2 In-house 4-141 (145) alignment
Range on Protein: 1-145
Range on HMM: 4-141/145.0
MSRVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYWfghrllpSTVRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSA
.|....|||.|||   .| .|. .||.  .   .. ....         .. .   . . | .  |.|..|.|.|.|||.|..|.| |.|||.|||.|..
pseilpglylgslptaldlellkdlgittvlnltselelle.......rlgiqylylpwpDhgvpdllellleflefieealkeggpvlVHCsaGvgRtg

TVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
|.|.||||. ||..  .|......... | ||||....|..||..
tlvaaylmlllgvsleealelvrsqrpgavpnpgqlrflyefele

0048179 (Phosphotyrosine protein) phosphatases II 1-144 2.2e-28 94.1 In-house 4-142 (144) alignment
Range on Protein: 1-144
Range on HMM: 4-142/144.0
MSRVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYWFGHRllpstVRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSA
.|....|||.|||  ..| .|. .||.. .   .. . ......      . .   . . | .  |.|..|.|.|.|||.|..|.| |.|||.|||.|..
pseilpglylgslptaldlellkklgittvinlteeyepeflere.....giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtg

TVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
|.|.||||. |||.  .|........  | ||||. ..|...||
tlvaaylmkklglsleealalvrsrrpgavpnpgqlrfLleyek

subfamily_DSP15_pd Subfamily DSP15 1-147 1.7e-26 87.1 In-house 2-140 (151) alignment
Range on Protein: 1-147
Range on HMM: 2-140/151.0
MSRVDDGLYIGSLELLQDHALMGELGVSSIAGSAHrrswywFGHRLLPStvRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSA
.|.|  |||.| ..  .|..|..|  .. |             ..||.    . | | . |  .|.. ... |. .|| ..|.... |.||| ||||||.
iskvlpglylgnfrdskdeelLkeknithilsvhd......nakkllkd..ieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsv

TVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMKC
|.|.||||  . ||  .|....|||   | || ||..||. .||.| 
tlvvaYlmtvtelnwrdalevikaaRsvanPnfGfkrqlkeyektkl

0041856 (Phosphotyrosine protein) phosphatases II 2-149 4.7e-23 77.1 In-house 20-175 (182) alignment
Range on Protein: 2-149
Range on HMM: 20-175/182.0
SRVDDGLYIGSLEL--------------LQDHALMGELGVSSIAGSAhrRSWYWFghRLLPSTVRRQKSILVFDEEQADilswLPEALDFIESARSEDGI
... ..||.|||                 ..  .. |||...|   .     ||    ||. .. . . . . | .  |    |.|.||||| ...|.| 
dyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlt..eelywp..ellerlgiqylylpwpDhgvpd....ldelldfieevleeggp

VYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHR--PALPNPGFQQQLRLFEKMKCTL
|.||| |||.|..|.|.||||. ||..  .|..... .       || .|  || |.|....  
vlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmvitpnqyfflqlallellllkk

0046846 (Phosphotyrosine protein) phosphatases II 2-145 7.4e-22 73.4 In-house 13-171 (176) alignment
Range on Protein: 2-145
Range on HMM: 13-171/176.0
SRVDDGLYIGSLE----------LLQDHALMGELGVSSIAGSAHRRSWYWFGHRLLPSTVR----RQKSILVFDEEQADIlSWLPEALDFIESARSEDGI
......|..||.           | .. ... |||.. .     ..   ...   ... ..    . . . . |    |. ..|.|.|.||..|..|.| 
dyinanlilgsrpiatqgplprtladflemlkelgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdl.elllellefirealkeggp

VYVHCQAGVSRSATVVMAYLMRN-LGLNCSKAFRMLKAAHR-PALPNPGFQQQLRLFEKM
|.|||.||..|..|.|.|||..   ||.  .|...... ..  |...|.. ..|. ||..
vlVHCsaGigRtgtlvaayllelekglsveealalvreqRplgavqtpeQyrflyefell

0036282 (Phosphotyrosine protein) phosphatases II 2-145 2.3e-21 71.7 In-house 13-168 (174) alignment
Range on Protein: 2-145
Range on HMM: 13-168/174.0
SRVDDGLYIGSLELLqDHALMGELGVSSIAGSAHRRSW-------YW-FGHRLLPSTVRRQKSILVFDEEQADILSwLPEALDFIESARSE--DGIVYVH
|.. ..|..|.  |  . ... |||....    . . .       ||   .  |  .. . . . . | .  |.   | |...|.|.|.||  .| |.||
syitprliagqgpla.fwemlkelgittvvmlleekelglykcinywpelredlerlgiqylylpwpDhgvpdlsi.llefvkfveealsedpggpvlVH

CQAGVSRSATVVMAYLMRNLGL-NCSKAFRMLKAAH---RPALPNPGFQQQLRLFEKM
| |||.|..|.|.||||  ..| .  .|........    .. ..|.. ..|. |||.
CsaGvgRtGtlvaaylmlrglleslvdaldlvrelRlqrpgmvqtpsQyrflyyfekl

0051082 (Phosphotyrosine protein) phosphatases II 2-140 1.7e-17 58.9 In-house 9-147 (151) alignment
Range on Protein: 2-140
Range on HMM: 9-147/151.0
SRVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYwFGHRLLPSTVRRQKSILVFDEEQADILSWLPEALDFIESARSE-DGIVYVHCQAGVSRSA
|.|..|||...  | .. .|. |||...|        .. . ...||.. .. . | ..|    ..  .....|.|.| ...  .| |.||| ||..|..
syvtgglyrsggpladflellkelgiktivnlrseeerg.ycpeylpelgievlhipildwpdpglplsfdavleflellldkkngpvlvHCsaGkgRTG

TVVMAYLMRnLGLNCSKAFRMLKAAHR-PALPNPGFQQQLR
|.|..|||  ||..  .|...... .     || .|. ||.
tlvalylml.lgvsleealeeyrlkrpgvvqpnqqflfqlf

subfamily_DSP19_pd Subfamily DSP19 3-146 1.2e-37 123.5 In-house 14-150 (152) alignment
Range on Protein: 3-146
Range on HMM: 14-150/152.0
RVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYWfghrllPSTVrRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATV
 | . ||.|| .  .|.  . | ..  |   |      .      |. .   .|| ..|....|.||.|.|||||||.|||.||.|.|||.|||||||.|
eveprlylgsqdvaadkeilkekkitHilnvatgvpnvf......pkdf.tylsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasv

VMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMK
|.||||..  |....|......|.... || ||..||. .|. .
viaylmkkeelsleealelvrearpcikPneGFikqLkeyeael

subfamily_DSP1_pd Subfamily DSP1 3-146 1.7e-28 93.8 In-house 20-156 (163) alignment
Range on Protein: 3-146
Range on HMM: 20-156/163.0
RVDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWYwFGHrllpstVRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATV
.. | ||.|| .   .  .. .||.. |   ... . . | .      . . |.. . |...||| ... |...||.......| |..|||||.|||.|.
kildfLylGsetvasnleiLkslgitailnvskeldnv.fed......lfeYkklkleDspkadislvfeeviefidevkkknGkvlihCqaGisRsstl

VMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMK
..||||..  .. ..|| . |       || ||..||  .||  
claylmktkrvsleeafdfvkqrRsiisPnagFvlqLlnyekkl

PTEN_1 4-145 6.4e-24 79.9 In-house 44-190 (196) alignment
Range on Protein: 4-145
Range on HMM: 44-190/196.0
VDDGLYIGSLELL-QDHALMGELGVSSIAGSAHRRSWywFGHRLLPST--VRR--QKSILVFDEEQADILSWLPEALDFIESARS--EDGIVYVHCQAGV
.|.|||.|||... .|   ..| |. ..   ....     | .  ...   ..  .... . |    .. ... .. .|||...|  . ..|.|||.||.
ideglyrgslkdvaadldnlkedgitlvvnlseeeel..sgrsydleeffksgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGl

SRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
.||.|||.||||.  .|.  .|.......  |. ||...|..|. ....
gRsGtvvaayLmykgkltadeAlelvrekRppgapnspsqerlleyfae

subfamily_DSP8_pd Subfamily DSP8 4-144 7.2e-24 78.1 In-house 18-152 (159) alignment
Range on Protein: 4-144
Range on HMM: 18-152/159.0
VDDGLYIGSLELLQDHALMGELGVSSIAGSAHRRSWywfgHRLLPSTVrrQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVV
. . ||.|| .   .. |. .||.| .  . .           |. .      . | |. . ..| |......||. |.||.| | ||. || ||||||.
ilknlylGsqkdvlseellsklgisyvlnasnscpk....leelkesk..flrvPvkDkydekllpwfdksvefidkaksengrvlvhvlaGisrsatva

MAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
.||.|..| ..  .|.| .|       ||  |..||  .||
iayimktlemsldeayrfvkekrptispnlnflgqLleyek

subfamily_DSP3_pd Subfamily DSP3 4-143 5.5e-23 75.4 In-house 14-154 (162) alignment
Range on Protein: 4-143
Range on HMM: 14-154/162.0
VDDGLYIGSLELLQDHALMGELGVSSIAGSAHRrSW--YWFGHRLLPSTVRRQKSILVFDEEQADILSWLPEALDFIESARSE-DGIVYVHCQAGVSRSA
| ..||.|  .  .|.  . .||.  .  .|.  ..     |.     .  .   . | |  ..|.  .  .| .||..| |. .| |.|||..||||||
vypklyvgdeavakdkskLkklGithvlnaaeg.rfskvdtgaefykdleikylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsa

TVVMAYLMRNLGLNCSKAFRMLKaAHRPALPNPGFQQQLRLFE
|.|.||||    ..  .| |  . ..|  ||| || .||. ..
tlvlayLmirrkmtlveairtvr.kkReilPneGFlkqLaeld

subfamily_LRR-DSP_pd Subfamily LRR-DSP 4-144 4e-21 69.3 In-house 123-256 (263) alignment
Range on Protein: 4-144
Range on HMM: 123-256/263.0
VDDGLYIGSLELLQDHALMGELGVSSI-AGSAHRRSWYwfghrllPSTVRRQkSI-LVFDEEQADILSWLPEALDFIESARSEDGiVYVHCQAGVSRSAT
. |.|..|.|.  ...... .|||. |    |. .  .       | . .   ||  . | ..|||  .. |   |||. | . | | |||.||||||.|
iidklflGgldsannksilkdlgvthillavadfePlf.......Pklfkyl.siddiedvdeadisqhfeetnafieeGrkkGG.vlvhcraGvsrsst

VVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
.|..|||..  |.  .|. . .       |||||..||. .||
lvisylmkkqrlkfkealdlvikkrpriqPnpGfkdqlkkyek

0037934 (Phosphotyrosine protein) phosphatases II 5-144 2.8e-20 68.3 In-house 43-239 (243) alignment
Range on Protein: 5-144
Range on HMM: 43-239/243.0
DDGLYIGSL--------ELLQDHALMGELGVSSIA-------GSAHRRSWYW-------------------------------FGHRLLPSTVRRQKSIL
 ..|.....         | ..  .. |||...|         ..    .||                                ..  |. .|..   . 
tprliatqgPlpetveddlasfwrmlwelgitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylp

VFD----EEQADILSWLPEALDFIES-----ARSEDGIVYVHCQAGVSRSATVVMAYLMRNL-GLNCSKAFRMLKAAHRP-ALPNPGFQQQLRLFEK
. |    .. .|.|..| |. .|||.     |....| |.||| |||.|..|...||||  | |..  .|...|..     | ..|.. ..|. ...
wpdhgvPdspedlldfldevrefieellsllaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpgkavqtpsqyrflyeall

subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 7-144 6.4e-15 49.0 In-house 14-145 (148) alignment
Range on Protein: 7-144
Range on HMM: 14-145/148.0
GLYIGSLELLQDHALMGELGVSSIAGSAHrRSWYWFGHRllpsTVRRQkSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAY
 |..|| .   |   . .|||. |   ..      . .|    ...    . . |... |. .  ... .|.. |..| . | ||.| |||||. .....
fLFlGskksaadlealkalgvtrivnatk.erdnaldqr....gieYl.hvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallw

LMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
|..       .|. . | . |   ||.|| .||  .|.
lidfkrvslkealalvkskrryvdpnlgfLkqLaeleq

subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 8-144 2.8e-16 52.9 In-house 6-139 (145) alignment
Range on Protein: 8-144
Range on HMM: 6-139/145.0
LYIGSLELLQDHALMGELGVSSIAGSAHRRSWywfGHRLLPSTVRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYL
||.||    .| ... |||.| |   |   .      . | |       |   | |  |.   . |  |||.  . |   |.||| |||||| || .|.|
lyvgsalhandvptlqelgisrivnmaagslv...asqelksesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvafl

MRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
|.  ..  |.| | ...    | ||  | ..|  .||
mkycnmtlseaarqvrsnrllaypnvtflknllnlek

0043147 (Phosphotyrosine protein) phosphatases II 47-149 1.4e-24 82.2 In-house 61-163 (172) alignment
Range on Protein: 47-149
Range on HMM: 61-163/172.0
LPSTVRRQKSILVFDEEQAdILSWLPEALDFIES--ARSEDGIVYVHCQAGVSRSATVVMAYLMRnLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
|  .. .   . . |     .|..|.|.|.||..  |.|..| |.||| |||.|..|.|.||||. |||.  .|....... . | .||.....|. |||
lerlgiqylylpwpDhgvp.llellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpgavqnpsqyrflyyfek

MKCTL
.  .|
lllll

0049260 (Phosphotyrosine protein) phosphatases II 48-145 5.9e-21 70.2 In-house 55-148 (152) alignment
Range on Protein: 48-145
Range on HMM: 55-148/152.0
PstvrRQKSILVFDEEQADILSWLPEALDFIES-ARSEDGIVYVHCQAGVSRSATVVMAYLMRnLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
.    . . . . |    |.  .|...|.|||  |....| |.||| |||.|..|.|.||||. ||..  .|.......   | ||||. ..|  |||.
i....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekRpgavpnpgqlrflyefekl

0049772 (Phosphotyrosine protein) phosphatases II 49-146 2e-26 88.9 In-house 178-273 (314) alignment
Range on Protein: 49-146
Range on HMM: 178-273/314.0
STVRRQKSILVFDeEQADILSWLPEALDFIESArSEDGIVYVHCQAGVSRSAT-VVMAYLMRNLGLNCSKAFRMLKAAHRpALPNPGFQQQLRLFEKMK
 .. . . | | | ..|..|....|.|.|||.| ...| |.|||.||..|..| ||.||||. ||..  .|........  . ||||| .||...|.. 
rlgikylripvpD.gsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp.inpnpgfieqleqyefil

DSPc Dual specificity phosphatase, catalytic domain 51-144 4.6e-28 92.7 Pfam-A 39-132 (133) alignment
Range on Protein: 51-144
Range on HMM: 39-132/133.0
VRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
 ... .| | ||....| ..|.|| .|||.|... . |.||||||.|||||...||||.  .|. ..|....|       || ||..||. .|.
eieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLleyer

DSPc Dual specificity phosphatase, catalytic domain 51-144 4.6e-28 92.7 In-house 39-132 (133) alignment
Range on Protein: 51-144
Range on HMM: 39-132/133.0
VRRQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
 ... .| | ||....| ..|.|| .|||.|... . |.||||||.|||||...||||.  .|. ..|....|       || ||..||. .|.
eieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvkerrskispnagflrqLleyer

0040439 (Phosphotyrosine protein) phosphatases II 51-145 7e-20 67.1 In-house 139-244 (249) alignment
Range on Protein: 51-145
Range on HMM: 139-244/249.0
VRRQKSILVFDEEQADILSWLPEALDFIESARS------EDGIVYVHCQAGVSRSATVVMAYLM-----RNLGLNCSKAFRMLKAAHRPALPNPGFQQQL
.|. . | ..|    .. ......||||| .|.      ..| |.||| |||.|..|...||||     ..||..   |...|. . . | .||.. ..|
srtvlhiqytdwpdhgvppsfedlldfieavrkaleelpkggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRpgavqnpeqyrfl

RLFEKM
  ....
yealle

subfamily_DSP6_pd Subfamily DSP6 53-145 2.4e-25 82.9 In-house 61-153 (158) alignment
Range on Protein: 53-145
Range on HMM: 61-153/158.0
RQKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
. . | . |. .... ...|||..||. |||..  | ||| ||.||| ||..||||..| |   .|. ..|. .    ||  | .||  ||..
kylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksnisPnfnfmgqlldfers

0051429 (Phosphotyrosine protein) phosphatases II 53-165 2e-14 49.4 In-house 71-244 (272) alignment
Range on Protein: 53-165
Range on HMM: 71-244/272.0
RQKSILVFDEEQADILSWL------------------------------------------------PEALDFIESARSeDGIVYVHCQAGVSRSATVVM
|   . ..|..  .|| .                                                  . |...|  .. .| |.||| ||..|..|||.
rylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallellellld.ggpvlvHCsaGkdRTGtvva

AYLMRnLGLN--------------CSKAFRMLKAAHRPALPNPGFQQQLRLFE-KMKCTLDDSNPDYRLYRLEHLT
..|.  ||..                .| ..|.|. . | ..... ..|. .. .. ..| .....| |. |... 
lllll.lgvsletivddYlltnlyleeaveelraqrpgavqteeqylflyeallellrsllsvraeyllaaldaid

subfamily_DSP14_pd Subfamily DSP14 54-144 6.5e-25 81.9 In-house 52-142 (157) alignment
Range on Protein: 54-144
Range on HMM: 52-142/157.0
QKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
.  . | |...|.. ... |. | ||... ..| . ||| |||||||....||||.   |.  .|....|.|     || || .||. .||
rvkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNvGFwkqlidyEk

subfamily_DSP10_pd Subfamily DSP10 54-144 9.1e-24 78.1 In-house 61-151 (159) alignment
Range on Protein: 54-144
Range on HMM: 61-151/159.0
QKSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
 | | | | .. ..     |||.||| ||...  | ||||||.|||||||.||||..|.|. ..|... | .     || .|  ||  |||
YkripvsDtskqnlkqyfeealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLlefek

subfamily_Slingshot_pd Subfamily Slingshot 55-145 8.7e-23 74.5 In-house 66-156 (169) alignment
Range on Protein: 55-145
Range on HMM: 66-156/169.0
KSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
. | |.|||..|.|..  |. .||| |....  | |||. ||||||..|.|| |.. ||.  .|.. .|   . . ||.|| .||. .| .
lnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPnkgflkqleeyeGi

subfamily_STYXL1_pd Subfamily STYXL1 55-146 5.9e-18 58.6 In-house 62-153 (157) alignment
Range on Protein: 55-146
Range on HMM: 62-153/157.0
KSILVFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMK
  | | ||..||.|. | || .|||. . |. .| |  . |.||||.|..|||| .  ..  ||.  ||  .    || .| .||. .||. 
lhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnrafveqlseWekql

0038934 (Phosphotyrosine protein) phosphatases II 55-146 8.7e-18 60.1 In-house 83-176 (194) alignment
Range on Protein: 55-146
Range on HMM: 83-176/194.0
KSILVFDEEQADILSWLPEALDFIES--ARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMK
 .. . |   .  |. | . ||...   .....|.|.||| ||..|..|.| |||.  ||..  .| .... . ..|.||... ..|. . |. 
lklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlgRtGtlvaaYLiyrlgmsaeeAialfrekRpgaipnqdyleallkrykel

subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 57-145 2e-20 66.7 In-house 61-151 (154) alignment
Range on Protein: 57-145
Range on HMM: 61-151/154.0
ILVFDEEQADILSWLPEALDFIESAR--SEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
. .||. . ||.  |  |..||..|    |.. | ||...||||||.....||| .| .. |.|. .|| .     || || .||  ||| 
lelfddvnfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryiikPnqGflkqleifeke

0045098 (Phosphotyrosine protein) phosphatases II 59-145 3.1e-20 68.2 In-house 166-270 (278) alignment
Range on Protein: 59-145
Range on HMM: 166-270/278.0
VFDEEQADILSWLPEALDFIESARS--------------EDGIVYVHCQAGVSRSATVVMAYLMRNL---GLNCSKAFRMLKAAHRP-ALPNPGFQQQLR
 ..    .||... |.|.||..|..              ..| |.|||.|||.|..|.|.||||. |   |..  .|...|.   .  |..|......| 
dhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpglavqnleqyrfly

LFEKM
 |. .
eflle

0042113 (Phosphotyrosine protein) phosphatases II 59-144 2.2e-18 62.0 In-house 148-240 (245) alignment
Range on Protein: 59-144
Range on HMM: 148-240/245.0
VFDEEQADILSWLPEALDFIESARS--EDGIVYVHCQAGVSRSATVVMAYLM-----RNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
. |   .|.|..| ..|.|...|..  ..| |.||| |||.|..|...||||     ..||..  .|...|.   . | ..|.. ..|. ...
wpdhgvpdllellldflefvrkalaedsngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRpgavqtpsqyrflyeall

subfamily_MKPLT_pd Subfamily MKPLT 59-146 3.4e-17 56.4 In-house 73-160 (164) alignment
Range on Protein: 59-146
Range on HMM: 73-160/164.0
VFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMK
| || .  . |.|  | .|. .|    | |.|||. |.|||..| .|.|..  |    .|.  ||     . || || .||  ||.. 
vedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeeli

subfamily_MKPLV_pd Subfamily MKPLV 59-146 3.4e-17 56.4 In-house 73-160 (164) alignment
Range on Protein: 59-146
Range on HMM: 73-160/164.0
VFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMK
| || .  . |.|  | .|. .|    | |.|||. |.|||..| .|.|..  |    .|.  ||     . || || .||  ||.. 
vedesdeqlssfleraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsivapnrGflkqlakfeeli

subfamily_STYX_pd Subfamily STYX 59-145 4.6e-17 55.6 In-house 70-156 (166) alignment
Range on Protein: 59-145
Range on HMM: 70-156/166.0
VFDEEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
| |.   .|. .||.  .||... .. | | || .||.||||..|.||.|   ||.  .||....       || || .||. .| .
vadntveniirylptvkefiddslqkggkvlvhgnagisrsaalviayimetyglkyreafayvqerrfcinpnegfvsqlkeyeai

0036941 (Phosphotyrosine protein) phosphatases II 60-145 1.8e-16 55.7 In-house 176-275 (297) alignment
Range on Protein: 60-145
Range on HMM: 176-275/297.0
FDEEQADILSWLPEALDFIESARS------EDGIVYVHCQAGVSRSATVVMAYLM--------RNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
..    .. ..  . ||||| .|.      ..| |.||| |||.||.|...|.||        .. |..  .|...|.     | ..... ..|. .. .
tgwpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRpgavqtleqyrflyealle





0039614 (Phosphotyrosine protein) phosphatases II 61-145 6.8e-18 60.6 In-house 195-287 (297) alignment
Range on Protein: 61-145
Range on HMM: 195-287/297.0
DEEQADILSWLPEALDFIESARS---EDGIVYVHCQAGVSRSATVVMAYLM-----RNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
|    ..|. | |.|.....|..   ..| |.||| |||.|..|...||||     .. |..  .|...|. . . | ..|.. ..|. ....
dhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRpgavqtpsqyrflydalle

subfamily_PTPMT1_pd Subfamily PTPMT1 62-144 7.7e-16 53.0 In-house 84-166 (171) alignment
Range on Protein: 62-144
Range on HMM: 84-166/171.0
EEQADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
  .|  |  | ....|||. .|.   |||||.|| .||||.| .||| .  |.  .| ..||.  .  . .   ...|. .|.
fteapdleklekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkqwkalqeyee

0045450 (Phosphotyrosine protein) phosphatases II 63-145 5.8e-19 64.4 In-house 206-302 (307) alignment
Range on Protein: 63-145
Range on HMM: 206-302/307.0
EQADILSWLPEALDFIESARS------EDGIVYVHCQAGVSRSATVVMAYLMRNLG--------LNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
   .. ... |.||||| .|.      ..| |.||| |||.|..|...||||  ..        ..  .|...|..    | .||.. ..|. ....
pdhgvppsfeelldfieevrkaleelpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRpgavqnpeqyrflyealle

0040438 (Phosphotyrosine protein) phosphatases II 64-147 3.7e-17 58.0 In-house 184-276 (317) alignment
Range on Protein: 64-147
Range on HMM: 184-276/317.0
QADILSWLPEALDFIESARSE----DGIVYVHCQAGVSRSATVVMAYLM-----RNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKMKC
  .. ... . |||.| .|.     .| | ||| |||.|..|...||||     .. |..  .|...|... . | ..|.. ..|  .. . .
dhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelreqRpgavqtpeqyrflydalleyl

subfamily_MSG5_pd Subfamily MSG5 64-145 1.2e-13 44.5 In-house 78-159 (165) alignment
Range on Protein: 64-145
Range on HMM: 78-159/165.0
QADILSWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEKM
.. |   |..    | .|.|.   . |||| |.||||....||.|.  .|   .|. .||.      |. |.  ||  .| .
dskivkdlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksvaddispsiglifqlmeweva

0051299 (Phosphotyrosine protein) phosphatases II 66-132 9.9e-11 37.1 In-house 196-271 (288) alignment
Range on Protein: 66-132
Range on HMM: 196-271/288.0
DILSWLPEALDFIESARSE----DGIVYVHCQAGVSRSATVVMAYLM-----RNLGLNCSKAFRMLKAAHRPALPN
.. . . . |||.. .|.     .| |.||| |||.|..|.....|.     .. |..  .|...|.     . ..
gvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRpgmvqt

0048567 (Phosphotyrosine protein) phosphatases II 66-142 5.7e-10 33.8 In-house 55-134 (157) alignment
Range on Protein: 66-142
Range on HMM: 55-134/157.0
DILSWLPEALDFIESARSEDGIVYVHCQAGV---SRSATVVMAYLMRNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLF
 . ..   . .|... . ... ..||| ||    .|.||.. .||.  ||.. ..|...|. .. . .| .  .. |.|.
ilyrFilklnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplrivrpgsvpfrdasyllsly

subfamily_Laforin_pd Subfamily Laforin 69-129 1.2e-08 28.0 In-house 94-153 (183) alignment
Range on Protein: 69-129
Range on HMM: 94-153/183.0
SWLPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLkAAHRPA
  ||.|. .. .   .  ||||||.||| ||...|  .|.  || . .|   .|  |.||.
enlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfl.lakrpv

0047943 (Phosphotyrosine protein) phosphatases II 70-139 4.3e-12 41.5 In-house 184-264 (273) alignment
Range on Protein: 70-139
Range on HMM: 184-264/273.0
WLPEALDFIESARS------EDGIVYVHCQAGVSRSATVVMAYLM-----RNLGLNCSKAFRMLKAAHRPALPNPGFQQQL
 | . |.||| .|.      ..| |.||| |||.|..|.....|.     .. |..  .|...|.     . ..| . ..|
slesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRpgmvqtpeqyrfl

0043336 (Phosphotyrosine protein) phosphatases II 71-144 6e-14 47.6 In-house 196-274 (278) alignment
Range on Protein: 71-144
Range on HMM: 196-274/278.0
LPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLM-----RNLGLNCSKAFRMLKAAHRPALPNPGFQQQLRLFEK
|    ...|  ....| |.||| |||.|..|....||.     ...|..  .|...|.     |...| . ..|. ...
ldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRpgavqtpsqyrflyeall

0050432 (Phosphotyrosine protein) phosphatases II 71-129 1.8e-10 36.1 In-house 216-281 (308) alignment
Range on Protein: 71-129
Range on HMM: 216-281/308.0
LPEALDFIESARSE--DGIVYVHCQAGVSRSATVVMAYLM-----RNLGLNCSKAFRMLKAAHRPA
. . |||.| .|.   .| ..||| |||.|..|.....|.     .. |..  .|...|.     .
peilldflelvrkslpggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRpgm

subfamily_Dicty-DSP-Subfam1_pd Subfamily Dicty-DSP-Subfam1 71-119 4e-06 19.6 In-house 52-100 (128) alignment
Range on Protein: 71-119
Range on HMM: 52-100/128.0
LPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAF
...  . . | |    ..||||. |. |.  |. .| |. .| .  ||.
irdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkal

subfamily_Dicty-DSP19-1_pd Subfamily Dicty-DSP19-1 71-119 4e-06 19.6 In-house 51-99 (128) alignment
Range on Protein: 71-119
Range on HMM: 51-99/128.0
LPEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAF
...  . . | |    ..||||. |. |.  |. .| |. .| .  ||.
irdyrnillserelplvlyvhcecgcdrtgevlasyvmkykgydlkkal

PTPc_DSPc_SM00012 72-111 4.1e-07 25.5 In-house 27-65 (105) alignment
Range on Protein: 72-111
Range on HMM: 27-65/105.0
PEALDFIESARSeDGIVYVHCQAGVSRSATVVMAYLMRNL
 .  .. . . |  . | |||.|||.|..|.|..... . 
ravkknknkses.skpvvVhCsaGvgRtgtfvaldillqq

subfamily_DSP11_pd Subfamily DSP11 72-126 1.3e-06 22.4 In-house 103-157 (178) alignment
Range on Protein: 72-126
Range on HMM: 103-157/178.0
PEALDFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAH
 .  .|.|.   .| .. |||  || |.  ..  ||.   |.. ..| .... | 
eavkefleknkdndkligvhCthGvnrtGyliCrylidvegyepedaieafeear

0046845 (Phosphotyrosine protein) phosphatases II 73-128 8.3e-10 34.0 In-house 186-255 (284) alignment
Range on Protein: 73-128
Range on HMM: 186-255/284.0
EALDFIESAR------SEDGIVYVHCQAGVSRSATVVMAYLMRNL--------GLNCSKAFRMLKAAHRP
  |.|.. .|      . .| . ||| |||.|..|.....|. ..        |..  .|...|.     
dlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRpg

subfamily_PTEN_pd Subfamily PTEN 73-116 7.7e-06 21.0 In-house 100-145 (184) alignment
Range on Protein: 73-116
Range on HMM: 100-145/184.0
EALDFIESA--RSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCS
|... ||.   .... .| |||.||  |. ....|||. .| |. .
eivediekwleedkknvvvvHCkaGkGRtGvlivayllksllleka

subfamily_CDC14_pd Subfamily CDC14 76-128 3.9e-07 24.2 In-house 254-305 (328) alignment
Range on Protein: 76-128
Range on HMM: 254-305/328.0
DFIESARSEDGIVYVHCQAGVSRSATVVMAYLMRNLGLNCSKAFRMLKAAhRP
 |.| | . .| . |||.||. |  |.. .|||.. ... . |   |. . ||
kfleiaekaeGaiavhCkaGLGrtGtLiacylmkhyrftaaeaiawlric.rP