Gene PTPMT1 in Monosiga brevicollis

Gene expression:

Classification

Phosphatases were first clustered by sequence similarity in the phosphatase domain, and additional information from domains outside of the catalytic domain, from evolutionary conservation, and from known functions was added. The result is a hybrid classification, in which no criterion is universally satisfied, but aims to be of practical use to a range of phosphatase interests. The classification grows as new phosphatomes are sequenced.

Level Class Gene list Wiki page
Fold CC1
Superfamily CC1
Family DSP
Subfamily PTPMT1
Protein sequence
ID Type Fasta BLAST phosphatome Note
MbreP016_AA protein Get Run
MbreP016_AA_143-319 phosphatase_domain Get Run
Domains
Summary
Details
Domain Domain Description Range Significance Score Source Profile Range (length) Alignment
DUF2207 Predicted membrane protein (DUF2207) 29-111 4.1e-06 11.9 Pfam-A 369-453 (511) alignment 
Range on Protein: 29-111
Range on HMM: 369-453/511.0
QQWLEALRQEAAVSSVPRPEPDRQRLK--TGLAVAAAVSAVMSFGVVVYATVLISFATYCWLFNVAVHPVATLFITVLVLLAWVS
..| .....||  .. ..... ... .  .|| .........||... . . | .. . ..|.....  |  |.| .|.|  ...
kkwqksvkeearkkglfdeyrylrsnekklgllilgilllilsfiliifllalfaglllaalvllvivlvigliiallllrkllg
0044763 (Phosphotyrosine protein) phosphatases II 138-295 1.1e-22 75.9 In-house 15-154 (178) alignment 
Range on Protein: 138-295
Range on HMM: 15-154/178.0
FGAKRPFNYNVIDDFIIVGRLPRdvadyehlIRVRRLFHHLNVArvppsrsnfkfrilAVVDCTETWEHLVPI--SAVRAATNLDILNIRTPDYAAVD-W
. . ...|.. |......| ||          . ..|.. |..               ..|..||. |.  .         ...  |.| .||. . |  
lersdyinaseilpglylgslpp........addlellkelgit..............hivnlteelelgflkcdpywpeeagiqylhipipDhgvpdll

EDLLKAMEFIRQYA-SGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRNIT
| .|...|||...  . |..|.|||. |.||..|.. |.||.. .|.| .|.. |...|.| 
ehflefvefieealdekggpvlVHCsaGvgRsgtlvaaylmkklglsleeaielvrerRpiv
subfamily_PTPMT1_pd Subfamily PTPMT1 139-320 1.4e-56 185.6 In-house 14-171 (171) alignment 
Range on Protein: 139-320
Range on HMM: 14-171/171.0
GAKRPFnYNVIDDFIIVGRLPrdvadYEHLIrvRRLFHHLNVARVPPSRSNFKFRILAvvDCTETWEHLvpisavraatNLDILNIRTPDYA-AVDWEDL
..||.. |..|||..|.|.||     ...||  ..|... ||..|...........||  ..||.|..|          ....|...|.|.. |.|.|.|
askrnw.ydriDdtvilGalP.....frsli..keLiekenvkavvslneeyelkala..nsteewkkl..........gveqlqlatvDfteapdlekl

LKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRNITNLAKFGgllpvWHLLQRYERFLLSK
.|..|||...|| |.||||||..|.||.||.....||..|.|....||||.|.||.|..|||..     |..||.||..||||
ekgvefiekvaskgkrvYvHCkaGrgRsatlvacylmkkeklspeeAlkalkkkRkiirlakkq.....wkalqeyeekllsk
0051082 (Phosphotyrosine protein) phosphatases II 142-293 2.9e-16 54.9 In-house 4-133 (151) alignment 
Range on Protein: 142-293
Range on HMM: 4-133/151.0
RPFNYNVIDDFIIVGRLPRDvadyehliRVRRLFHHLNVARvppsrsnfkfrilaVVDCTETWEHLvPISAVRAATNLDILNIRTPDYAAVDW----EDL
 ..|.. ........  | .        .. .|...|..                .|......|.         ......|.|  .|  . .     . .
dyinfsyvtgglyrsggpla........dflellkelgikt..............ivnlrseeerg.ycpeylpelgievlhipildwpdpglplsfdav

LKAMEFIRQyaSGGHRVYVHCNGGKGRAATIATAWLMLrERLDLKSALKAVKSKRN
|...|....   ... |.|||..|||| .|.. ..||| ....| .||. ...|| 
leflellld..kkngpvlvHCsaGkgRTGtlvalylml.lgvsleealeeyrlkrp
0041856 (Phosphotyrosine protein) phosphatases II 144-294 2.3e-19 65.1 In-house 17-154 (182) alignment 
Range on Protein: 144-294
Range on HMM: 17-154/182.0
FNYNVIDDFIIVGRLPR------------DVADYEHLIRVRRLFHHLNVARVPPSRSNFkfrilavvdctetwehlvpisavrAATNLDILNIRTPDYAA
 ... | . ...| ||             .|||. .... ..  . .|.. ..   ...                          ... .|..  ||. .
rdldyInanlylgslpatrfiatqgpllstvadflrmlkelgittivnlteelywpell........................erlgiqylylpwpDhgv

VDwedLLKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRN--I
 |   | .. .||..  . |..|.|||..|.||..|.. |.||.. ...| .|.| |.|.|.  .
pd...ldelldfieevleeggpvlVHCsaGvgRtgtlvaaylmkklgvsleeavklvrsrRpgmv
0036282 (Phosphotyrosine protein) phosphatases II 145-292 1.5e-18 62.6 In-house 11-146 (174) alignment 
Range on Protein: 145-292
Range on HMM: 11-146/174.0
NYNVIDDFIIVGRLPRDvadyehlirVRRLFHHLNVARVPPSRSNFKFRILAVVDCTETwehlvpISAVRAATNLDILNIRTPDYAAVDWEDLLKAMEFI
. ..| . .|.|  | .           .....|..  |   .. .   .  . . . .       .     ... .| . .||. . | . ||....|.
dlsyitprliagqgpla.........fwemlkelgittvvmlleekelglykcinywpe......lredlerlgiqylylpwpDhgvpdlsillefvkfv

RQYASG--GHRVYVHCNGGKGRAATIATAWLMLRERL-DLKSALKAVKSKR
... |   |. |.|||..|.||..|.. |.||||  | .|  ||. |...|
eealsedpggpvlVHCsaGvgRtGtlvaaylmlrglleslvdaldlvrelR
0048076 (Phosphotyrosine protein) phosphatases II 147-295 2.4e-20 68.2 In-house 5-125 (145) alignment 
Range on Protein: 147-295
Range on HMM: 5-125/145.0
NVIDDFIIVGRLPrDVADYEHLIRvRRLFHHLNVarvppsrsnfkfrilavvdcTETWEHLVpisavraATNLDILNIRTPDYAAVDW-EDLLKAMEFIR
. |.. . .| || .. |.|.| .   . . ||.                    | . | |.       .... .|.. .||. . |  |.||...|||.
seilpglylgslp.taldlellkd.lgittvlnl....................tselelle.......rlgiqylylpwpDhgvpdllellleflefie

QYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRNIT
.. . |..|.|||. |.||..|.. |.|||.....| .||. |.|.| . 
ealkeggpvlVHCsaGvgRtgtlvaaylmlllgvsleealelvrsqrpga
0038934 (Phosphotyrosine protein) phosphatases II 167-293 5e-15 51.1 In-house 30-157 (194) alignment 
Range on Protein: 167-293
Range on HMM: 30-157/194.0
HLIRVRRLFHHLNVARVPPSRSNFKFRILAVVDCTETwEHLVPISAVRAAtNLDILNIRTPDY-AAVDWEDLLKAMEFIRQYA--SGGHRVYVHCNGGKG
.| ..   ......  .    . .. .. .|.| |.| |..   . . .| ....|.. .||. .. . | ||. .... ..   . |. |.||| .|.|
sldkyieelyrfspedlvrylkllnvklglvidltnt.eryYdpeefeka.gieylklpfpddgtvPsleillrfldlvdeflnedpggvvaVHCkaGlg

RAATIATAWLMLRERLDLKSALKAVKSKRN
|..|.. |.|. | ..... |.. ...||.
RtGtlvaaYLiyrlgmsaeeAialfrekRp
PTPc_motif_SM00404 191-296 3.2e-16 54.5 In-house 25-125 (140) alignment 
Range on Protein: 191-296
Range on HMM: 25-125/140.0
KFRILAVVDCTET--WEhlvpisavRAATNLDILNIRTPDYAAV-DWEDLLKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKA
|..| .|...||.  ..        ..  .  ||.|   |       ..| |...||.. .. |..|.|||  |  | ||...|.|| .. |.|..|...
klgithvinvteevslt........kensgfqilqiplddnekdklskyldkvldfienaekkggkvlVHCqaGvSRSatliiaYlmryrqlslaeayef

VKSKRNITN
||..|.| .
vkerRpiis
DSPc Dual specificity phosphatase, catalytic domain 191-296 7.1e-16 53.3 Pfam-A 16-118 (133) alignment 
Range on Protein: 191-296
Range on HMM: 16-118/133.0
KFRILAVVDCTETWEHLvpisAVRAATNLDILNIRTPD-YAAVDWEDLLKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVK
|. | .|...|.. ..       .. .. . |.|   |   .   ..| .|.|||.. .. |..|.|||. |  | ||...|.|| ...|.|..|...||
klgitlvinvtkevpnn....naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvk

SKRNITN
..|.. .
errskis
DSPc Dual specificity phosphatase, catalytic domain 191-296 7.1e-16 53.3 In-house 16-118 (133) alignment 
Range on Protein: 191-296
Range on HMM: 16-118/133.0
KFRILAVVDCTETWEHLvpisAVRAATNLDILNIRTPD-YAAVDWEDLLKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVK
|. | .|...|.. ..       .. .. . |.|   |   .   ..| .|.|||.. .. |..|.|||. |  | ||...|.|| ...|.|..|...||
klgitlvinvtkevpnn....naikkseieylripvedetetkiskeleeavefiekaeqkgkkvlVHCqaGisRSatliiaYlmktknlslneAyefvk

SKRNITN
..|.. .
errskis
0046846 (Phosphotyrosine protein) phosphatases II 192-293 5.4e-21 70.6 In-house 46-152 (176) alignment 
Range on Protein: 192-293
Range on HMM: 46-152/176.0
FRILAVVDCTETWEHL----VPISAVRAATNLDILNIRTPDYAAVDWEDLLKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLR-ERLDLKSALK
 .| |||..|| .|.       .  .  . .. .|.. .||. . | |.||...||||.. . |..|.||| .|.||..|.. |.|. .   |..  ||.
lgitavvnlteevelgrlkcpnywpeleklgiqylhlpwpDhgvpdlelllellefirealkeggpvlVHCsaGigRtgtlvaayllelekglsveeala

AVKSKRN
 |...| 
lvreqRp
0048179 (Phosphotyrosine protein) phosphatases II 192-295 1.1e-20 69.2 In-house 28-127 (144) alignment 
Range on Protein: 192-295
Range on HMM: 28-127/144.0
FRILAVVDCTETWEHLVPISAvraatNLDILNIRTPDYAAVDW-EDLLKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKS
. | .|...||..|.  ..       .. .|.. .||. . |  |.||...|||... . |..|.|||..|.||..|...|.||....|.|..||. |.|
lgittvinlteeyepeflere.....giqylhlpwpDhgvpdllellleflefieealeeggpvlVHCsaGvgRtgtlvaaylmkklglsleealalvrs

KRNIT
.| . 
rrpga
0042113 (Phosphotyrosine protein) phosphatases II 192-293 2.6e-17 58.5 In-house 75-223 (245) alignment 
Range on Protein: 192-293
Range on HMM: 75-223/245.0
FRILAVVDCTETWEH---------------------------------------LVPISAVRAATNLDILNIRTPDYAAVD-WEDLLKAMEFIRQYAS--
 .| ..|..||..|.                                       ....      ... .. .  ||. . |  |.||...||.|.. .  
lgittivmLteeeelgrvkcaqywplgesltygdftvtllseehlddytvrtlevtnlgddesrevihyhylpwpdhgvpdllellldflefvrkalaed

GGHRVYVHCNGGKGRAATIATAWLM-----LRERLDLKSALKAVKSKRN
....|.|||..|.||..|...|.||      . ...| .|.| ..|.| 
sngpvlVHCsaGvgRtGtfiaaylmleqlekelgvsleeavkelrsqRp
0037934 (Phosphotyrosine protein) phosphatases II 193-294 2.4e-16 55.5 In-house 72-222 (243) alignment 
Range on Protein: 193-294
Range on HMM: 72-222/243.0
RILAVVDCTETWEHLVP-------------------------------------IS-AVRAATNLDILNIRTPDYAAVD-WEDLLKAMEFIRQ-------
.| ..|..||..|. .                                      ..      ..  .. .  ||. . |  ||||. ....|.       
gitvivmltelvElgrekcaqywpgevtygdftvtllseehlddytvrtlllenldlddltrlvihyhylpwpdhgvPdspedlldfldevrefieells

--YASGGHRVYVHCNGGKGRAATIATAWLMLRE-RLDLKSALKAVKSKRNI
  ....|..|.||| .|.||..|...|.|||.  ..|| .|.| ....|. 
llaldsggpvlVHCsaGvgRtGtliaaylmllllgvdleeavkllreqRpg
0040439 (Phosphotyrosine protein) phosphatases II 194-293 3.2e-14 48.6 In-house 79-226 (249) alignment 
Range on Protein: 194-293
Range on HMM: 79-226/249.0
ILAVVDCTETWEH---------------------------------------LVPISAVRAATNLDILNIRTPDYAAV-DWEDLLKAMEFIRQYAS---G
| ..|..|.. |.                                       |...      | | |  .  ||. .  . ||||. .| .|.. .    
itvivmLtslvelgrekcaqywplggsleygdftvtllsvevkddytvrtleltnlydgesrtvlhiqytdwpdhgvppsfedlldfieavrkaleelpk

GHRVYVHCNGGKGRAATIATAWLM-----LRERLDLKSALKAVKSKRN
|..|.|||..|.||..|...|.||      . ..||..|.| ..|.|.
ggpvlVHCsaGvgRtGtfiaaylmleqlekelgvdleeavkllrsqRp
0051429 (Phosphotyrosine protein) phosphatases II 194-296 1.7e-13 46.4 In-house 46-208 (272) alignment 
Range on Protein: 194-296
Range on HMM: 46-208/272.0
ILAVVDCTETWEHLVpISAVRAATNLDILNIRTPDYAAVDW----------------------------------------------------EDLLKAM
| ..|| ....|.       | . ....|.. ..|..| .                                                     | ||...
iktivdLrseeErgr.lkcdrywpgirylhlpilddsaptilygalrvtllseellldyilrellltlllsagearevmhlhytdwpdhgvpqeallell

EFIRQyasgGHRVYVHCNGGKGRAATIATAWLMLrERLD--------------LKSALKAVKSKRNITN
|....    |..|.|||..||.| .|.. ..|.| ....              |  |.. ....|   .
ellld....ggpvlvHCsaGkdRTGtvvalllll.lgvsletivddYlltnlyleeaveelraqrpgav
0049260 (Phosphotyrosine protein) phosphatases II 195-294 2.1e-16 55.4 In-house 35-131 (152) alignment 
Range on Protein: 195-294
Range on HMM: 35-131/152.0
LAVVDCTETWEHLVPISAVRAatnlDILNIRTPDYAAVDWEDLLKAMEFIRQY--ASGGHRVYVHCNGGKGRAATIATAWLMLrERLDLKSALKAVKSKR
 ..| .||  |   .  .        .|.. .||. . | ..||. .  . .    . |..|.||| .|.||..|.. |.|||  ...|. |.. |..||
ttivmltellelgklkceqyi....qylhlpwpDhgvpdlsqlllflllfieklaldkggpvlVHCsaGvgRtgtlvaaylml.lgvsleeavalvrekR

NI
..
pg
0045450 (Phosphotyrosine protein) phosphatases II 195-293 6.4e-15 51.1 In-house 133-284 (307) alignment 
Range on Protein: 195-293
Range on HMM: 133-284/307.0
LAVVDCTETWEH------------------------LVPISAvraATNLDILNI--------------------RTPDYAAV-DWEDLLKAMEFIRQYAS
 ..|..||. |.                        |. ..      .. ....                    . ||. .  ..|.||. .| .|.. .
tvivmltelvelgrekcaqywPdegeeltygnftvtllseeh...ldgytvrtlevtdldgtgesrtvthfhytgwpdhgvppsfeelldfieevrkale

---GGHRVYVHCNGGKGRAATIATAWLMLRER--------LDLKSALKAVKSKRN
   .|..|.|||..|.||..|...|.|||| .        .|| .|.| ....| 
elpkggpvlVHCsaGvgRtGtfiaaylmlrqlekegtlldvdlleavkllreqRp
subfamily_Choan-DSP_MKP-1_pd Subfamily Choan-DSP_MKP-1 196-295 4.4e-12 39.7 In-house 36-130 (148) alignment 
Range on Protein: 196-295
Range on HMM: 36-130/148.0
AVVDCTEtwEHLVPIsAVRaatNLDILNIRTPDYAAVDWEDLL-KAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRNI
..|..|.  |.  .. ..|    .. |...  |    |   .  ....|.|.  . |.|| ||.. |  |.. .| .||.  .|  || || .|||||. 
rivnatk..erdnal.dqr...gieYlhvaldDkpkedlsaiFediiafvrkakdeGrrvLvhlqmGvsrssalallwlidfkrvslkealalvkskrry

T
 
v
0043147 (Phosphotyrosine protein) phosphatases II 197-294 6.6e-19 63.7 In-house 48-142 (172) alignment 
Range on Protein: 197-294
Range on HMM: 48-142/172.0
VVDCTETwehlVPISAVRAATNLDILNIRTPDYAAVDWEDLLKAMEFIRQ--YASGGHRVYVHCNGGKGRAATIATAWLMLrERLDLKSALKAVKSKRNI
.|..||     . .      ... .| .  ||. . . | ||...|||..    | |..|.||| .|.||..|.. |.||| ..|.|  |.. |..||..
ivnltel....lydpellerlgiqylylpwpDhgvpllellleflefidellalspggpvlVHCsaGvgRtgtlvaaylml.lglsleeavalvrekRpg
0048567 (Phosphotyrosine protein) phosphatases II 206-290 2.9e-06 21.7 In-house 62-116 (157) alignment 
Range on Protein: 206-290
Range on HMM: 62-116/157.0
HlvpisavraatnldilnirtpdyaavdwedllkAMEFIRQYASGGHRVYVHCNGGK---GRAATIATAWLMLRERLDLKSALKAVKS
.                                 ...|....   |....|||  |    ||.||.. ..|.|. ...   |.. .. 
k.................................lnkflkilelagkaiavhckaglkkrgrtatLigcYlilhlgftpeeaiaplri
0049772 (Phosphotyrosine protein) phosphatases II 209-293 2e-20 69.2 In-house 176-255 (314) alignment 
Range on Protein: 209-293
Range on HMM: 176-255/314.0
PisavrAATNLDILNIRTPDYAAVDWEDLLKAMEFIRQYaSGGHRVYVHCNGGKGRAAT-IATAWLMLRERLDLKSALKAVKSKRN
.       ...  |.| .||. | . ||.....|||... . |..|.|||..||||..| ...|.||.. ...|. ||. |..|| 
f.....erlgikylripvpDgsaplledfdeflefieea.dkggpvlvHCkaGkgRtgtfvvaaylmkllgvsleealedvrlkRp
subfamily_DSP15_pd Subfamily DSP15 211-296 3.6e-10 34.1 In-house 37-123 (151) alignment 
Range on Protein: 211-296
Range on HMM: 37-123/151.0
SAVRAATNLDILNIRTPDYAAVDWEDLLK-AMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRNITN
.| .   ... . |.  | . .. .  .| ..||| .  . .. |.|||  |  |..|...|.||    |. . ||...| .| . |
nakkllkdieYkciaasDtpsaklskffkesvefihkcRlkeenvlvhClaGvsRsvtlvvaYlmtvtelnwrdalevikaaRsvan
0043336 (Phosphotyrosine protein) phosphatases II 212-293 3.3e-13 45.2 In-house 171-257 (278) alignment 
Range on Protein: 212-293
Range on HMM: 171-257/278.0
AVRAATNLDILNIRtpDYAAV-DWEDLLKAMEFIRQYAS-GGHRVYVHCNGGKGRAATIATAWLM-----LRERLDLKSALKAVKSKRN
 .|  | .  |..   |. .  . ..||. ....|.. .  .. |.|||..|.||..|.....|.      . ..|| .|.| ....| 
esrtvthyhylgwp..dhgvpeslsllldflkavrealedsngpvlVHCsaGvgRTGtfialyllleqlekeggvdleeavkelreqRp
subfamily_DSP23_pd Subfamily DSP23 213-292 1.2e-06 23.3 In-house 46-125 (148) alignment 
Range on Protein: 213-292
Range on HMM: 46-125/148.0
VRAATNLDILNIRTPDYAAVDWEDLLKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKR
| |. || . ..| .||     |.. . .. . .  . .  | |||  |.||. |. . .|.  ..|    |.  |. .|
veatpnltlvrlriddyhppaleqvvefvrvveeaeekneavsvhcllgrgrtgtmlacylvkerklaaaeaiaevrrlr
subfamily_DSP6_pd Subfamily DSP6 214-294 6.1e-10 32.8 In-house 55-137 (158) alignment 
Range on Protein: 214-294
Range on HMM: 55-137/158.0
RAATNLDILNIRTPDYAAVDWEDLL-KAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKR-NI
. . .|  |.|   | .  .   .. .|.||| .  |    | |||  |  |. |.. |.|| .. | |..| . ||... ||
eesgelkylqipiedhlsqnlakffPeaiefidearskkskvlvhClaGisrsvtvtlaylmkklalslndaydlvkkrksni
0045098 (Phosphotyrosine protein) phosphatases II 216-294 1.5e-16 56.0 In-house 153-252 (278) alignment 
Range on Protein: 216-294
Range on HMM: 153-252/278.0
ATNLDILNI-RTPDYAAVDWE---DLLKAMEFIRQYAS--------------GGHRVYVHCNGGKGRAATIATAWLMLRE---RLDLKSALKAVKSKRNI
  .. .|..   ||. . . .    .|...||||.. .              .|..|.|||. |.||..|.. |.|||.    ..|| .|.| ..|.|..
srgvthlhylpwpdhgvpslpilksflellefirealkllaslllsslllldsggpvlVHCsaGvgRtGtlvaaylmlelleggvdlleavkelrsqRpg
0040438 (Phosphotyrosine protein) phosphatases II 216-293 2.4e-14 48.8 In-house 153-256 (317) alignment 
Range on Protein: 216-293
Range on HMM: 153-256/317.0
ATNLDILNIRT-------------------PDYAAV-DWEDLLKAMEFIRQYASG-GHRVYVHCNGGKGRAATIATAWLM-----LRERLDLKSALKAVK
  .  .....                    ||. .  ....||. .|..|.. .. |. | |||..|.||..|...|.||      ....|...|.| ..
lagitlrtlevedlgdsesrtvthfhytgWpdhgvppspdllldfleavrealedpggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdveeavkelr

SKRN
..|.
eqRp
subfamily_Sponge-DSP-Subfam1_pd Subfamily Sponge-DSP-Subfam1 216-293 2.7e-07 23.8 In-house 44-122 (145) alignment 
Range on Protein: 216-293
Range on HMM: 44-122/145.0
ATNLDILNIRTPDYAAVDWEDLL-KAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRN
. ...|| | . |  . |  . . .  .|| .    |  |.|||  |  |. |.. |.||    . |  | . |.|.| 
sesieillitaedlesydlsqhfdevtdfidkgkeegagvfvhcmagvsrsvtvsvaflmkycnmtlseaarqvrsnrl
PTEN_1 217-319 4.1e-17 57.6 In-house 93-193 (196) alignment 
Range on Protein: 217-319
Range on HMM: 93-193/196.0
TNLDILNIRTPDYAAVDWEDLLK-AMEFIRQYAS--GGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKR-NIT-NlakfgglLPVWHLLQ
 ..  |..  .|. | . . |.. . .|| .. |   |. |.||| .|.|| .|.. |.|| ...|. . ||. |..|| ..  |        | .  |.
sgveylhfpieDhgapslselfdicksfiewllsdpngnvVlVHCkaGlgRsGtvvaayLmykgkltadeAlelvrekRppgapn.......spsqerll

RYERFLLS
.|.. ||.
eyfaella
subfamily_DSP14_pd Subfamily DSP14 217-315 1.5e-11 38.5 In-house 48-142 (157) alignment 
Range on Protein: 217-315
Range on HMM: 48-142/157.0
TNLDILNIRTPDYAAVDWEDLL-KAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRNITNLAKfGgllpVWHLLQRYER
 ... ....  |  ...  . . .... |..    |... |||  |  | |....|.||  |.| |. | |.|||.|.| .    |     |. |..||.
kdiervkvpveDnpeaklakhfdevadkieevkkkggktlvhCvaGvSRSAslclaylmkyeklsLreayklvksaRpiirPNv.G....FwkqlidyEk
subfamily_PTPDC1_pd Subfamily PTPDC1 219-293 2.8e-10 34.9 In-house 83-156 (182) alignment 
Range on Protein: 219-293
Range on HMM: 83-156/182.0
LDILNIRTPDYAAVDWEDLLKAMEFIRQYASGGhRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRN
. . |.  .|| .   | .|  .  . .  . | .| |||  |.||.  . ...|.  .||. . |.| |.||| 
iyvynfgwkDygvasleriLdivkvvafalqeg.kvavhChaGlGrtGvliacylvyakrltaekaiklvrskrp
subfamily_STYXL1_pd Subfamily STYXL1 219-299 1.8e-08 27.8 In-house 59-141 (157) alignment 
Range on Protein: 219-299
Range on HMM: 59-141/157.0
LDILNIRTPDYAAVDW-EDLLKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKS-KRNITNLAK
 ..|.|.  |    |  | | .|..|| ..   |. | |  | |  |.|... |.||  ... ||.|.| .|  | |.    .
akllhiavedeneadllerlkeavqfiekhkkegevvlvfsnkGisrsaaviiaylmyskkitlkkaykylkkCkenvkPnra
subfamily_Slingshot_pd Subfamily Slingshot 220-298 3.1e-09 30.4 In-house 64-143 (169) alignment 
Range on Protein: 220-298
Range on HMM: 64-143/169.0
DILNIRTPDYAAVD-WEDLLKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRNITNLA
. ||||  |  . | ..   .. .||..  . | .| |||  |  |.|..  |. | . .|.|..||. ||..|....  
eylnirvydeeetdllkywnetykfiekakkkgskvlvhckmGvsrsastviayamkeyglsleealeyvkerrsvikPn
subfamily_VSP_pd Subfamily VSP 220-291 2.3e-06 21.7 In-house 95-169 (212) alignment 
Range on Protein: 220-291
Range on HMM: 95-169/212.0
DILNIRTPDYAAVDWEDLLKAMEFIRQYASGGH--RVYVHCNGGKGRAATIATAWLMLRERLD-LKSALKAVKSK
 . .|.. |.     |.||.  . .... .  .   . .|| |||||. ||  |.|.  | ..  | .|.   ..
rvkriliddhnvpkleellvftkevkewlekdlknvlaihckGGkgrtGtivcalllaseifetakesldyfger
subfamily_DSP3_pd Subfamily DSP3 221-295 1.3e-13 44.9 In-house 65-141 (162) alignment 
Range on Protein: 221-295
Range on HMM: 65-141/162.0
ILNIRTPDYAAVDWEDL-LKAMEFIRQYASG-GHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRNIT
 | .   |  ..| .    .|..||..  |    .|.|||. |  |.||.. |.||.|....|..|...|..||.|.
ylGlevdDvpefdlskyFetaakfidealsqkegkvlvhcvvGvsRsatlvlayLmirrkmtlveairtvrkkReil
subfamily_DSP12_pd Subfamily DSP12 221-295 1.1e-12 42.6 In-house 51-126 (155) alignment 
Range on Protein: 221-295
Range on HMM: 51-126/155.0
ILNIRTPDYAAVD---WedLLKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRNIT
 ..|   |   .|   .  | .|..|| .  . .  |.|||. |  | .|| .|.|| .|.|.|..|||.||.|.. .
tkfiqilDepeediLsh..ldeavdFieealeeegavlvHCqagvSRSvtiviAYlmkkeklslekAlklvkekkpei
subfamily_DSP19_pd Subfamily DSP19 222-293 2e-13 44.9 In-house 59-131 (152) alignment 
Range on Protein: 222-293
Range on HMM: 59-131/152.0
LNIRTPDYAAVDWED-LLKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRN
|.|   |    |  . | .|..||..  |   .|.|||| |  |.|... |.|| .|.|.|..||. |...| 
lsieilDlpetdllsylkealdFieearskdgavlvHCnAGvSRsasvviaylmkkeelsleealelvrearp
0039614 (Phosphotyrosine protein) phosphatases II 224-293 5.7e-15 51.0 In-house 191-269 (297) alignment 
Range on Protein: 224-293
Range on HMM: 191-269/297.0
IRTPDYAAV-DWEDLLKAMEFIRQYAS---GGHRVYVHCNGGKGRAATIATAWLM-----LRERLDLKSALKAVKSKRN
.  ||. .  . |.||...|..|.. .   .|..|.|||..|.||..|...|.||      . ..|...|.| ....|.
tgwpdhgvppslellleflelvrealaelpkggpvlVHCsaGvgRtGtfiaaylmleqlekeggvdvleavkelreqRp
0047943 (Phosphotyrosine protein) phosphatases II 225-293 4.1e-13 44.9 In-house 175-252 (273) alignment 
Range on Protein: 225-293
Range on HMM: 175-252/273.0
RTPDYAAV-DWEDLLKAMEFIRQYAS---GGHRVYVHCNGGKGRAATIATAWLM-----LRERLDLKSALKAVKSKRN
  ||. .  ..|.||. .|..|.. .   ... |.|||..|.||..|.....|.      . ..|...|.| ..|.| 
gwpdhgvppslesllefielvrkalealpsngpvvVHCsaGvgRtgtfialdllldqlekeggvdvleavkllrsqRp
0046845 (Phosphotyrosine protein) phosphatases II 225-293 1.3e-11 39.9 In-house 174-254 (284) alignment 
Range on Protein: 225-293
Range on HMM: 174-254/284.0
RTPDYAAV-DWEDLLKAMEFIRQYASG---GHRVYVHCNGGKGRAATIATAWLMLRE--------RLDLKSALKAVKSKRN
  ||. .  . ||||. ....|.. .    |. . ||| .|.||..|.....|.|.         ..|. .|.| ....|.
swpdhgvppspedlleflrlvrellenlpgggpivVHCsaGvgRtGtfialdllleqlekeglllgvdvleavkrlreqRp
0051299 (Phosphotyrosine protein) phosphatases II 225-293 3.5e-11 38.6 In-house 191-266 (288) alignment 
Range on Protein: 225-293
Range on HMM: 191-266/288.0
RTPDYAAVD-WEDLLKAMEFIRQY-ASGGHRVYVHCNGGKGRAATIATAWLM-----LRERLDLKSALKAVKSKRN
  ||. . | .|.||. ....|.. ||||. |.|||. |.||..|.....|.      ....|. .|.| ....|.
nwpdhgvpdspellldflrlvrkalasgggpvvVHCsaGvgRtgtfialdllleqlekeggvdvleavkrlreqRp
0036941 (Phosphotyrosine protein) phosphatases II 226-293 2.2e-13 45.6 In-house 178-257 (297) alignment 
Range on Protein: 226-293
Range on HMM: 178-257/297.0
TPDYAAVD-WEDLLKAMEFIRQYAS---GGHRVYVHCNGGKGRAATIATAWLM--------LRERLDLKSALKAVKSKRN
 ||. . . ...||. .|..|.. .   .|..|.|||..|.||..|...|.||         ....|...|.| ....|.
wpdhgvpespaslldfielvrkvlkllpsggpvlVHCsaGvgRsgtfiaadlmlqqledklkeggvdileavkklReqRp
0050432 (Phosphotyrosine protein) phosphatases II 226-293 7.8e-12 40.6 In-house 207-279 (308) alignment 
Range on Protein: 226-293
Range on HMM: 207-279/308.0
TPDYAAVD-WEDLLKAMEFIRQYAsGGHRVYVHCNGGKGRAATIATAWLM-----LRERLDLKSALKAVKSKRN
 ||. . . .|.||. .|..|..  .|. ..|||. | ||..|.....|.        ..|. .|.| ....|.
WpdhgvPpspeilldflelvrksl.pggpivVHCsaGvGRtGtfialdllleqlekeggvdvfeavkklReqRp
subfamily_PTEN_pd Subfamily PTEN 226-292 4e-06 21.9 In-house 87-156 (184) alignment 
Range on Protein: 226-292
Range on HMM: 87-156/184.0
TPDYAAVDWEDLLKAMEFIRQYASG--GHRVYVHCNGGKGRAATIATAWLMLRERLDLK-SALKAVKSKR
  |  .   | | ...| |... .    . | |||. ||||. .. .|.|. .  |. . .||.  ...|
fdDhnppplelleeivediekwleedkknvvvvHCkaGkGRtGvlivayllkslllekaeealelfaeaR
subfamily_Dicty-DSP19-like_pd Subfamily Dicty-DSP19-like 231-295 2.3e-08 27.5 In-house 68-135 (154) alignment 
Range on Protein: 231-295
Range on HMM: 68-135/154.0
AVD-WEDLLKAMEFIRQYASGGH--RVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRNIT
  |  | | ||.|||..  .| .  .| ||.. |  |.|... ..|| . .. |  ||. .|. | | 
nfdiiekldkafefiddaiggvennkvlvhsdkGvsrsaallisylmdklkislslalellkdsryii
subfamily_CDKN3_pd Subfamily CDKN3 233-292 9.2e-06 19.3 In-house 114-174 (202) alignment 
Range on Protein: 233-292
Range on HMM: 114-174/202.0
DWEDLLKAMEFIRQYASGGHRVYVHCNGGKGRAATIAT-AWLMLRERLDLKSALKAVKSKR
|  . || .| .|     ...  ||| || ||.. ...   |.| . .. | |.. ..  .
diasclkileelrinlkayrktlvhcygglgrsslviaclllylddtiepkdaidklrdlk
PTPc_DSPc_SM00012 235-277 9e-06 21.2 In-house 23-65 (105) alignment 
Range on Protein: 235-277
Range on HMM: 23-65/105.0
EDLLKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRE
 .||.|..  .. .. .. | |||  | ||..|.... ..|. 
lellravkknknksesskpvvVhCsaGvgRtgtfvaldillqq
subfamily_Laforin_pd Subfamily Laforin 236-295 2.3e-09 30.4 In-house 95-154 (183) alignment 
Range on Protein: 236-295
Range on HMM: 95-154/183.0
DLLKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRNIT
 | .|. ..      ||.||||||.| ||...|   .|.     .|.     . .|| ..
nlpqavyllhallekghivyvhcnagvgrstaivcgflqyvlgwslakvqyfllakrpvv
subfamily_MSG5_pd Subfamily MSG5 236-292 7.8e-06 19.1 In-house 84-140 (165) alignment 
Range on Protein: 236-292
Range on HMM: 84-140/165.0
DLLKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKR
|| .  . |    | .... |||. |  |.|..  |..|    | |. | . .||. 
dlsrltriihaatskrkkilvhcqcglsrsaslivayimkyynlslrdaydklksva
subfamily_DSP1_pd Subfamily DSP1 238-296 4.6e-13 43.6 In-house 82-140 (163) alignment 
Range on Protein: 238-296
Range on HMM: 82-140/163.0
LKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRNITN
 ...||| .  . . .|..||. |  |..|.  |.|| ..|. |. | . ||..|.| .
eeviefidevkkknGkvlihCqaGisRsstlclaylmktkrvsleeafdfvkqrRsiis
subfamily_DSP10_pd Subfamily DSP10 238-304 7.6e-13 42.6 In-house 79-147 (159) alignment 
Range on Protein: 238-304
Range on HMM: 79-147/159.0
LKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRNIT--NLAKFGGLL
 .|.||| .  . |.|| |||. |  |.||.. |.|| . .| |. | | ||.|| |   ||.  | ||
eealefieearkkgsrvLvhCqaGisrsatvviaYlmkhlnlslndaykfvkekrpiisPnLnfmGqLl
subfamily_MKPLT_pd Subfamily MKPLT 238-296 5.6e-10 33.0 In-house 86-144 (164) alignment 
Range on Protein: 238-296
Range on HMM: 86-144/164.0
LKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRNITN
 .| .|. .   .| ||.|||. || |..... |.|.. ..  || | . .| .| |..
eraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsiva
subfamily_MKPLV_pd Subfamily MKPLV 238-296 5.6e-10 33.0 In-house 86-144 (164) alignment 
Range on Protein: 238-296
Range on HMM: 86-144/164.0
LKAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRNITN
 .| .|. .   .| ||.|||. || |..... |.|.. ..  || | . .| .| |..
eraakfladaidsGGrvlvhcvqGksrsssvtvafLikskgwtlkeayeylkerrsiva
subfamily_DSP8_pd Subfamily DSP8 239-294 1.3e-10 35.1 In-house 81-136 (159) alignment 
Range on Protein: 239-294
Range on HMM: 81-136/159.0
KAMEFIRQYASGGHRVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRNI
|..||| .  |   || ||.  |. |.||.| |..| . ...| .| . ||.||. 
ksvefidkaksengrvlvhvlaGisrsatvaiayimktlemsldeayrfvkekrpt
subfamily_LRR-DSP_pd Subfamily LRR-DSP 249-293 4.8e-07 23.1 In-house 197-239 (263) alignment 
Range on Protein: 249-293
Range on HMM: 197-239/263.0
SGGhrVYVHCNGGKGRAATIATAWLMLRERLDLKSALKAVKSKRN
.||  | |||  |  |..|.  ..|| ..|| .| ||  |..||.
kGG..vlvhcraGvsrsstlvisylmkkqrlkfkealdlvikkrp